RHOH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.08694001
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.69706389
3regulation of gamma-delta T cell differentiation (GO:0045586)5.59014146
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.35082449
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.35082449
6negative T cell selection (GO:0043383)5.28778611
7regulation of gamma-delta T cell activation (GO:0046643)5.15880641
8antigen processing and presentation of endogenous antigen (GO:0019883)5.13799083
9regulation of B cell receptor signaling pathway (GO:0050855)4.95854801
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83267160
11negative thymic T cell selection (GO:0045060)4.82627306
12positive T cell selection (GO:0043368)4.66255590
13positive thymic T cell selection (GO:0045059)4.64333846
14interferon-gamma production (GO:0032609)4.59353292
15B cell receptor signaling pathway (GO:0050853)4.47447762
16T cell selection (GO:0045058)4.28545068
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.18666573
18positive regulation of B cell differentiation (GO:0045579)4.14004764
19regulation of B cell differentiation (GO:0045577)4.13633060
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08753160
21negative regulation of cell killing (GO:0031342)4.08753160
22regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.97621337
23thymic T cell selection (GO:0045061)3.96068516
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.91846650
25leukocyte aggregation (GO:0070486)3.91797460
26antigen receptor-mediated signaling pathway (GO:0050851)3.86733761
27response to interleukin-15 (GO:0070672)3.85257520
28T cell migration (GO:0072678)3.81734202
29cellular response to interleukin-15 (GO:0071350)3.81564037
30regulation of T cell receptor signaling pathway (GO:0050856)3.77471251
31negative regulation of T cell mediated immunity (GO:0002710)3.76442974
32V(D)J recombination (GO:0033151)3.72779468
33T cell receptor signaling pathway (GO:0050852)3.72359354
34positive regulation of defense response to virus by host (GO:0002230)3.69954393
35T cell homeostasis (GO:0043029)3.68063998
36ribosomal small subunit assembly (GO:0000028)3.60784735
37regulation of T cell tolerance induction (GO:0002664)3.60027431
38regulation of alpha-beta T cell proliferation (GO:0046640)3.59018329
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.55007047
40* mast cell activation (GO:0045576)3.52162589
41positive regulation of T cell mediated cytotoxicity (GO:0001916)3.41896144
42regulation of isotype switching to IgG isotypes (GO:0048302)3.39275652
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.37750674
44lymphocyte homeostasis (GO:0002260)3.34014541
45positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.30324704
46T cell costimulation (GO:0031295)3.30268311
47regulation of leukocyte mediated cytotoxicity (GO:0001910)3.28625058
48positive regulation of interleukin-2 production (GO:0032743)3.28263495
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.26028421
50positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.24917347
51positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.24693841
52lymphocyte costimulation (GO:0031294)3.24672249
53response to type I interferon (GO:0034340)3.22383490
54DNA deamination (GO:0045006)3.21811878
55regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.21596119
56mast cell degranulation (GO:0043303)3.20060348
57mast cell activation involved in immune response (GO:0002279)3.20060348
58regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.19438623
59positive regulation of granulocyte differentiation (GO:0030854)3.19202865
60cellular response to zinc ion (GO:0071294)3.18582831
61regulation of alpha-beta T cell activation (GO:0046634)3.18072365
62cellular response to type I interferon (GO:0071357)3.17989428
63type I interferon signaling pathway (GO:0060337)3.17989428
64regulation of interleukin-2 biosynthetic process (GO:0045076)3.17863130
65defense response to protozoan (GO:0042832)3.17814897
66regulation of cell killing (GO:0031341)3.16689263
67cytidine deamination (GO:0009972)3.16291041
68cytidine metabolic process (GO:0046087)3.16291041
69cytidine catabolic process (GO:0006216)3.16291041
70regulation of regulatory T cell differentiation (GO:0045589)3.15837501
71antigen processing and presentation via MHC class Ib (GO:0002475)3.15517423
72immunoglobulin mediated immune response (GO:0016064)3.12616318
73regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09321399
74positive regulation of cell killing (GO:0031343)3.09027380
75myeloid dendritic cell activation (GO:0001773)3.04607507
76* T cell differentiation (GO:0030217)3.04510582
77positive regulation of alpha-beta T cell activation (GO:0046635)3.03780169
78positive regulation of T cell differentiation in thymus (GO:0033089)3.03604894
79mature B cell differentiation (GO:0002335)3.03119681
80pyrimidine ribonucleoside catabolic process (GO:0046133)3.02420107
81leukocyte homeostasis (GO:0001776)3.02218558
82tolerance induction (GO:0002507)3.02098222
83negative regulation of phagocytosis (GO:0050765)3.01454970
84regulation of defense response to virus by host (GO:0050691)3.01411717
85regulation of T cell mediated immunity (GO:0002709)3.00563540
86activated T cell proliferation (GO:0050798)2.99900079
87positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99604998
88positive regulation of natural killer cell mediated immunity (GO:0002717)2.99604998
89lymph node development (GO:0048535)2.98849689
90alpha-beta T cell activation (GO:0046631)2.97004076
91response to protozoan (GO:0001562)2.96524718
92negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.96500078
93cellular response to interferon-beta (GO:0035458)2.96103915
94CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.95033022
95positive regulation of isotype switching (GO:0045830)2.92618787
96interferon-gamma-mediated signaling pathway (GO:0060333)2.91964672
97positive regulation of T cell mediated immunity (GO:0002711)2.91116598
98regulation of natural killer cell mediated immunity (GO:0002715)2.89435058
99regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89435058
100negative regulation of leukocyte mediated immunity (GO:0002704)2.89346108
101positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88829909
102NIK/NF-kappaB signaling (GO:0038061)2.88135960
103Arp2/3 complex-mediated actin nucleation (GO:0034314)2.87330626
104B cell proliferation (GO:0042100)2.86756548
105regulation of alpha-beta T cell differentiation (GO:0046637)2.86743475
106immune response-activating cell surface receptor signaling pathway (GO:0002429)2.86400122
107positive regulation of lymphocyte differentiation (GO:0045621)2.85319330
108positive regulation of alpha-beta T cell differentiation (GO:0046638)2.85010097
109regulation of T-helper 1 cell differentiation (GO:0045625)2.83457510
110positive regulation of T cell differentiation (GO:0045582)2.81979595
111positive regulation of tolerance induction (GO:0002645)2.81836948
112germinal center formation (GO:0002467)2.81783798
113B cell homeostasis (GO:0001782)2.80746534
114regulation of tolerance induction (GO:0002643)2.80230716
115alpha-beta T cell differentiation (GO:0046632)2.79877458
116positive regulation of humoral immune response (GO:0002922)2.78700464
117Peyers patch development (GO:0048541)2.77222562
118mucosal-associated lymphoid tissue development (GO:0048537)2.77222562
119B cell mediated immunity (GO:0019724)2.75898528
120natural killer cell activation (GO:0030101)2.75871007
121positive regulation of B cell activation (GO:0050871)2.75845534
122mature B cell differentiation involved in immune response (GO:0002313)2.74943452
123regulation of response to interferon-gamma (GO:0060330)2.74708746
124positive regulation of immunoglobulin production (GO:0002639)2.74257174
125regulation of T cell mediated cytotoxicity (GO:0001914)2.73733992
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72117137
127regulation of B cell mediated immunity (GO:0002712)2.69963227
128viral transcription (GO:0019083)2.69398481
129regulation of B cell proliferation (GO:0030888)2.69369503
130regulation of isotype switching (GO:0045191)2.68794869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.23349599
2E2F7_22180533_ChIP-Seq_HELA_Human5.17494807
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.16911890
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.47243351
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.32957272
6* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.39454913
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.36355781
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.34723323
9* MYC_22102868_ChIP-Seq_BL_Human3.02351507
10SCL_19346495_ChIP-Seq_HPC-7_Human2.94162055
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.91188394
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.87655698
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.86935660
14* MYB_26560356_Chip-Seq_TH2_Human2.84619332
15RUNX_20019798_ChIP-Seq_JUKART_Human2.80909734
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77793123
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.73820143
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.72255036
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.59928102
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48453692
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.40897233
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37747097
23* MAF_26560356_Chip-Seq_TH1_Human2.35254529
24* IRF8_27001747_Chip-Seq_BMDM_Mouse2.32602558
25* MYB_26560356_Chip-Seq_TH1_Human2.30662842
26SPI1_23547873_ChIP-Seq_NB4_Human2.29049555
27* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.27989497
28VDR_21846776_ChIP-Seq_THP-1_Human2.27107305
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22562964
30* UTX_26944678_Chip-Seq_JUKART_Human2.13592580
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10845105
32MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02068131
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97610940
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92843876
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.90569903
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85605371
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81323336
38* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78792241
39* VDR_24763502_ChIP-Seq_THP-1_Human1.78663766
40* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76872244
41CIITA_25753668_ChIP-Seq_RAJI_Human1.69029777
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68531957
43* GATA3_27048872_Chip-Seq_THYMUS_Human1.66073953
44* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61486307
45FOXP3_21729870_ChIP-Seq_TREG_Human1.59873471
46VDR_23849224_ChIP-Seq_CD4+_Human1.58044161
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57192032
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.54892972
49TCF7_22412390_ChIP-Seq_EML_Mouse1.54358258
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.54059128
51MAF_26560356_Chip-Seq_TH2_Human1.53791385
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52016088
53* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47266294
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42720210
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42619352
56GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42308858
57SPI1_23127762_ChIP-Seq_K562_Human1.36643388
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.32718447
59GATA1_22025678_ChIP-Seq_K562_Human1.31184820
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28809012
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27719774
62PU_27001747_Chip-Seq_BMDM_Mouse1.24359700
63* VDR_24787735_ChIP-Seq_THP-1_Human1.24088601
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.23640758
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.22578220
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21685203
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20593030
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20166999
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17095844
70GATA3_26560356_Chip-Seq_TH2_Human1.15486103
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.15173393
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14906788
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14420582
74* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12586852
75ELK1_19687146_ChIP-ChIP_HELA_Human1.11218743
76GATA3_26560356_Chip-Seq_TH1_Human1.11125005
77* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09893485
78SMRT_27268052_Chip-Seq_Bcells_Human1.08647973
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07320665
80* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07025463
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05332116
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04669304
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03491309
84* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02225603
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01114120
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97111531
87ZNF274_21170338_ChIP-Seq_K562_Hela0.96363182
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96224286
89* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93531653
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93362848
91* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93248047
92* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92550133
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.92325651
94MYC_18555785_ChIP-Seq_MESCs_Mouse0.91374959
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90768893
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90252753
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.89778581
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.89226741
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88448949
100* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87838662
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87834392
102ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87745242
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87716734
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86000670
105IRF1_19129219_ChIP-ChIP_H3396_Human0.85476490
106BCL6_27268052_Chip-Seq_Bcells_Human0.84781023
107P300_27268052_Chip-Seq_Bcells_Human0.84259038
108KDM2B_26808549_Chip-Seq_DND41_Human0.82819939
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82819754
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81176309
111EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80897742
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80710589
113* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80669648
114ETS1_20019798_ChIP-Seq_JURKAT_Human0.80124385
115XRN2_22483619_ChIP-Seq_HELA_Human0.79346530
116* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78564502
117* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76225761
118PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75727124
119MYC_18358816_ChIP-ChIP_MESCs_Mouse0.75077900
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74564190
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74229494
122MYC_19030024_ChIP-ChIP_MESCs_Mouse0.73570316
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.73418801
124TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.72620921
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.70833748
126GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.70501803
127* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70448152
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.67850240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.31327569
2MP0005671_abnormal_response_to4.19036565
3MP0003763_abnormal_thymus_physiology4.07253843
4MP0000685_abnormal_immune_system3.49175139
5MP0001800_abnormal_humoral_immune3.48564307
6MP0001790_abnormal_immune_system3.06751967
7MP0005387_immune_system_phenotype3.06751967
8MP0009785_altered_susceptibility_to3.05226264
9MP0005000_abnormal_immune_tolerance2.93427650
10MP0002166_altered_tumor_susceptibility2.92908086
11MP0002452_abnormal_antigen_presenting2.92239281
12MP0002396_abnormal_hematopoietic_system2.91411882
13MP0002723_abnormal_immune_serum2.89015526
14* MP0002420_abnormal_adaptive_immunity2.86843564
15* MP0002398_abnormal_bone_marrow2.86003168
16* MP0001819_abnormal_immune_cell2.83426443
17MP0005025_abnormal_response_to2.61239073
18* MP0000716_abnormal_immune_system2.51736070
19MP0002006_tumorigenesis2.47579088
20* MP0002148_abnormal_hypersensitivity_rea2.42550558
21* MP0000689_abnormal_spleen_morphology2.37877111
22MP0003436_decreased_susceptibility_to2.31753519
23* MP0002722_abnormal_immune_system2.31481359
24* MP0000703_abnormal_thymus_morphology2.30277404
25MP0009333_abnormal_splenocyte_physiolog2.25531467
26MP0002405_respiratory_system_inflammati2.20820462
27MP0002419_abnormal_innate_immunity2.19203222
28MP0004808_abnormal_hematopoietic_stem2.13000968
29* MP0002429_abnormal_blood_cell2.11414279
30MP0010155_abnormal_intestine_physiology2.04633934
31MP0006082_CNS_inflammation2.04480436
32MP0005464_abnormal_platelet_physiology2.01743154
33MP0003724_increased_susceptibility_to1.95210545
34MP0001853_heart_inflammation1.89691801
35MP0004947_skin_inflammation1.83464257
36MP0001873_stomach_inflammation1.74904760
37MP0010094_abnormal_chromosome_stability1.71781430
38MP0001845_abnormal_inflammatory_respons1.71516035
39MP0002933_joint_inflammation1.68282615
40MP0005174_abnormal_tail_pigmentation1.68094045
41MP0005075_abnormal_melanosome_morpholog1.66236815
42MP0003866_abnormal_defecation1.65086843
43MP0002138_abnormal_hepatobiliary_system1.60380135
44MP0001545_abnormal_hematopoietic_system1.53954824
45MP0005397_hematopoietic_system_phenotyp1.53954824
46MP0003303_peritoneal_inflammation1.52815275
47MP0002132_abnormal_respiratory_system1.52761903
48MP0008057_abnormal_DNA_replication1.51143646
49MP0000490_abnormal_crypts_of1.47510078
50MP0000465_gastrointestinal_hemorrhage1.41470187
51MP0004510_myositis1.25229021
52MP0000015_abnormal_ear_pigmentation1.24533728
53MP0008007_abnormal_cellular_replicative1.23351988
54MP0002095_abnormal_skin_pigmentation1.23326081
55MP0002009_preneoplasia1.22344770
56MP0008469_abnormal_protein_level1.19279317
57MP0005645_abnormal_hypothalamus_physiol1.19064493
58MP0002019_abnormal_tumor_incidence1.18819359
59MP0005310_abnormal_salivary_gland1.18706787
60MP0004381_abnormal_hair_follicle1.18673452
61MP0003693_abnormal_embryo_hatching1.18494325
62MP0008058_abnormal_DNA_repair1.18107513
63MP0003300_gastrointestinal_ulcer1.15868305
64MP0000858_altered_metastatic_potential1.13311174
65MP0003077_abnormal_cell_cycle1.12960311
66MP0000372_irregular_coat_pigmentation1.08190763
67MP0003045_fibrosis1.06979161
68MP0006054_spinal_hemorrhage1.05301889
69MP0009278_abnormal_bone_marrow1.00355590
70MP0001533_abnormal_skeleton_physiology0.99825418
71MP0002163_abnormal_gland_morphology0.97785051
72MP0003787_abnormal_imprinting0.97178982
73MP0001986_abnormal_taste_sensitivity0.95100455
74MP0005409_darkened_coat_color0.90749767
75MP0001501_abnormal_sleep_pattern0.89117807
76MP0002876_abnormal_thyroid_physiology0.87605956
77MP0001919_abnormal_reproductive_system0.86511289
78MP0003448_altered_tumor_morphology0.85112816
79MP0002693_abnormal_pancreas_physiology0.82886002
80MP0008961_abnormal_basal_metabolism0.79018023
81MP0002998_abnormal_bone_remodeling0.78592302
82MP0003111_abnormal_nucleus_morphology0.75279935
83MP0009764_decreased_sensitivity_to0.74797081
84MP0008872_abnormal_physiological_respon0.72607950
85MP0001851_eye_inflammation0.71882718
86MP0002277_abnormal_respiratory_mucosa0.69136159
87MP0009763_increased_sensitivity_to0.68550001
88MP0004957_abnormal_blastocyst_morpholog0.68254656
89MP0000313_abnormal_cell_death0.66498493
90MP0003172_abnormal_lysosome_physiology0.62894402
91MP0005379_endocrine/exocrine_gland_phen0.62789619
92MP0003646_muscle_fatigue0.62153952
93MP0010352_gastrointestinal_tract_polyps0.61963318
94MP0003828_pulmonary_edema0.60391992
95MP0001764_abnormal_homeostasis0.59678337
96MP0009765_abnormal_xenobiotic_induced0.59497724
97MP0008995_early_reproductive_senescence0.58703256
98MP0003943_abnormal_hepatobiliary_system0.57988908
99MP0003786_premature_aging0.57835658
100MP0002075_abnormal_coat/hair_pigmentati0.54424097
101MP0005058_abnormal_lysosome_morphology0.53703095
102MP0002136_abnormal_kidney_physiology0.53665488
103MP0001348_abnormal_lacrimal_gland0.52760262
104MP0003195_calcinosis0.52065471
105MP0000477_abnormal_intestine_morphology0.51881235
106MP0001191_abnormal_skin_condition0.50431411
107MP0000569_abnormal_digit_pigmentation0.50297995
108MP0005390_skeleton_phenotype0.48962596
109MP0005166_decreased_susceptibility_to0.48607408
110MP0001663_abnormal_digestive_system0.48374868
111MP0000350_abnormal_cell_proliferation0.47455942
112MP0000249_abnormal_blood_vessel0.47212898
113MP0000343_altered_response_to0.47068309
114MP0003795_abnormal_bone_structure0.47032133
115MP0001765_abnormal_ion_homeostasis0.47004052
116MP0003191_abnormal_cellular_cholesterol0.47001904
117MP0003656_abnormal_erythrocyte_physiolo0.46558845
118MP0003252_abnormal_bile_duct0.46118668
119MP0005389_reproductive_system_phenotype0.44805612
120MP0008873_increased_physiological_sensi0.44004003
121MP0008877_abnormal_DNA_methylation0.43960232
122MP0003183_abnormal_peptide_metabolism0.43656733
123MP0002083_premature_death0.43626810
124MP0002928_abnormal_bile_duct0.41721289
125MP0000371_diluted_coat_color0.41179909
126MP0010307_abnormal_tumor_latency0.40668793
127MP0004883_abnormal_blood_vessel0.40421897
128MP0001243_abnormal_dermal_layer0.40141755

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.61663666
2Abnormality of T cell number (HP:0011839)5.45637998
3Panhypogammaglobulinemia (HP:0003139)5.27898661
4Recurrent viral infections (HP:0004429)4.97327015
5Elevated erythrocyte sedimentation rate (HP:0003565)4.87356323
6B lymphocytopenia (HP:0010976)4.83191602
7Abnormality of B cell number (HP:0010975)4.83191602
8Severe combined immunodeficiency (HP:0004430)4.72566555
9Recurrent bronchitis (HP:0002837)4.65298558
10Thyroiditis (HP:0100646)4.64756397
11Agammaglobulinemia (HP:0004432)4.64234280
12IgM deficiency (HP:0002850)4.45678998
13Recurrent fungal infections (HP:0002841)4.44211960
14Abnormality of T cells (HP:0002843)4.39061191
15Combined immunodeficiency (HP:0005387)4.38724348
16IgG deficiency (HP:0004315)4.36854499
17Chronic otitis media (HP:0000389)4.18844988
18Recurrent abscess formation (HP:0002722)4.17250939
19Myositis (HP:0100614)4.15223279
20Meningitis (HP:0001287)3.94696310
21Eosinophilia (HP:0001880)3.86715674
22Recurrent bacterial skin infections (HP:0005406)3.79592588
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.77195521
24Chronic mucocutaneous candidiasis (HP:0002728)3.70959612
25Recurrent cutaneous fungal infections (HP:0011370)3.70959612
26Hypoplasia of the thymus (HP:0000778)3.60700724
27Abnormality of eosinophils (HP:0001879)3.58883807
28Eczematoid dermatitis (HP:0000976)3.56919878
29Lymphopenia (HP:0001888)3.55409558
30Recurrent sinusitis (HP:0011108)3.51206487
31Granulocytopenia (HP:0001913)3.47319485
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.42975069
33Thrombocytosis (HP:0001894)3.30389720
34Cellulitis (HP:0100658)3.20246239
35Abnormality of T cell physiology (HP:0011840)3.19835327
36Gastrointestinal stroma tumor (HP:0100723)3.19658705
37Recurrent skin infections (HP:0001581)3.17178481
38Vasculitis (HP:0002633)3.16032951
39Leukocytosis (HP:0001974)3.15904604
40Abnormality of the fingertips (HP:0001211)3.14272290
41Inflammation of the large intestine (HP:0002037)3.12236711
42Chronic sinusitis (HP:0011109)3.08175694
43Stomatitis (HP:0010280)3.05364017
44Chronic diarrhea (HP:0002028)3.05288519
45Gastrointestinal inflammation (HP:0004386)3.04515276
46Pustule (HP:0200039)3.03953113
47Mediastinal lymphadenopathy (HP:0100721)3.00839502
48Colitis (HP:0002583)2.96276183
49Lymphoma (HP:0002665)2.93166451
50Autoimmune hemolytic anemia (HP:0001890)2.91598927
51Nasal polyposis (HP:0100582)2.88763010
52IgA deficiency (HP:0002720)2.83929080
53Autoimmune thrombocytopenia (HP:0001973)2.81654130
54Stomach cancer (HP:0012126)2.76286339
55Encephalitis (HP:0002383)2.71867691
56Retrobulbar optic neuritis (HP:0100654)2.70294628
57Optic neuritis (HP:0100653)2.70294628
58Verrucae (HP:0200043)2.66282914
59Papilloma (HP:0012740)2.66282914
60Petechiae (HP:0000967)2.66014136
61Hypoproteinemia (HP:0003075)2.65768648
62Bronchitis (HP:0012387)2.60730453
63Obstructive lung disease (HP:0006536)2.56966558
64Chronic obstructive pulmonary disease (HP:0006510)2.56966558
65Gastrointestinal infarctions (HP:0005244)2.56199558
66Prolonged bleeding time (HP:0003010)2.46296846
67Abnormality of the nasal mucosa (HP:0000433)2.45401954
68Recurrent pneumonia (HP:0006532)2.45340024
69Orchitis (HP:0100796)2.42739886
70Recurrent lower respiratory tract infections (HP:0002783)2.42428794
71Increased IgM level (HP:0003496)2.41951482
72Hemoptysis (HP:0002105)2.26605545
73Spontaneous hematomas (HP:0007420)2.25629442
74Prostate neoplasm (HP:0100787)2.25332696
75Abnormality of the prostate (HP:0008775)2.24762068
76Pulmonary infiltrates (HP:0002113)2.24552396
77Osteomyelitis (HP:0002754)2.23803892
78Gangrene (HP:0100758)2.21021276
79Epistaxis (HP:0000421)2.20895984
80Emphysema (HP:0002097)2.20880978
81Reticulocytopenia (HP:0001896)2.19587924
82Sepsis (HP:0100806)2.19437017
83Abnormality of the pleura (HP:0002103)2.19209581
84Hypergammaglobulinemia (HP:0010702)2.19008032
85Recurrent otitis media (HP:0000403)2.11129492
86Alveolar cell carcinoma (HP:0006519)2.10143392
87Amaurosis fugax (HP:0100576)2.05910452
88Arterial thrombosis (HP:0004420)2.05335761
89Keratoconjunctivitis sicca (HP:0001097)2.05096416
90Abnormality of macrophages (HP:0004311)2.02401336
91Increased IgE level (HP:0003212)2.02217882
92Aplasia/Hypoplasia of the thymus (HP:0010515)1.99086969
93Basal cell carcinoma (HP:0002671)1.98926376
94Skin rash (HP:0000988)1.97706060
95Abnormal number of erythroid precursors (HP:0012131)1.97195824
96Neutropenia (HP:0001875)1.96935053
97Pulmonary embolism (HP:0002204)1.96539096
98Congenital stationary night blindness (HP:0007642)1.95753110
99Gingival bleeding (HP:0000225)1.95222590
100Chest pain (HP:0100749)1.94616078
101Abnormality of cells of the erythroid lineage (HP:0012130)1.92719167
102Acute hepatic failure (HP:0006554)1.92279911
103Leukopenia (HP:0001882)1.91224367
104Neoplasm of the tracheobronchial system (HP:0100552)1.91187556
105Abnormality of male internal genitalia (HP:0000022)1.90026823
106Joint swelling (HP:0001386)1.89026684
107Urticaria (HP:0001025)1.88935550
108Skin ulcer (HP:0200042)1.88922353
109Anorexia (HP:0002039)1.88836667
110Keratitis (HP:0000491)1.88334422
111Recurrent gram-negative bacterial infections (HP:0005420)1.87436539
112Aplastic anemia (HP:0001915)1.87431772
113Acute myeloid leukemia (HP:0004808)1.86628568
114Hypochromic anemia (HP:0001931)1.84952371
115Keratoconjunctivitis (HP:0001096)1.84676045
116Restrictive lung disease (HP:0002091)1.81106461
117Pulmonary fibrosis (HP:0002206)1.78291674
118Purpura (HP:0000979)1.76000956
119Attenuation of retinal blood vessels (HP:0007843)1.72075273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.35079935
2TXK4.64333289
3BLK2.61372523
4JAK32.55183491
5ZAP702.54112298
6KIT2.43485319
7IKBKE2.34572407
8TYK22.22941726
9SYK2.22575995
10NME22.20191789
11ITK2.19676971
12STK102.17615100
13MAP3K142.16723884
14TEC2.15657916
15NLK2.13278302
16BTK2.09158685
17TBK12.06731336
18MAP3K102.02069895
19IRAK41.94119294
20CSF1R1.89408370
21GRK61.83839686
22LCK1.76936343
23FRK1.71991124
24TGFBR21.69177639
25CLK11.68683746
26BMPR21.60319271
27TESK21.54382244
28MAP3K131.54089692
29IKBKB1.47986569
30MST41.43805605
31JAK11.43465486
32LYN1.40623912
33FGFR41.35468911
34FLT31.32161401
35HCK1.30752388
36CSK1.27561807
37CAMKK21.26089486
38RIPK41.25157041
39PIM11.24691681
40EEF2K1.22891238
41IRAK11.19800372
42FGFR31.13012413
43SIK31.03713795
44TLK11.02460776
45RPS6KA41.00108776
46ADRBK20.95167678
47PRKCQ0.93682784
48MAP2K20.92429522
49VRK10.92426274
50FES0.90049629
51PIK3CG0.87871037
52TAOK30.87450642
53PRPF4B0.87245373
54EPHA30.84960004
55STK40.84305813
56CAMKK10.83497444
57LRRK20.82704887
58MARK30.79896288
59KDR0.79346555
60BCKDK0.77919249
61IRAK30.77225980
62SIK20.76718429
63ZAK0.76487023
64CHUK0.75622302
65MAP4K20.73300686
66PRKCH0.71508667
67ACVR1B0.69597612
68YES10.69357403
69MAP2K30.64889027
70TNK20.62881767
71STK160.62123044
72TGFBR10.62022839
73CDK40.61784394
74PIM20.61289923
75TNIK0.59960163
76MAPK70.58940052
77ERN10.58849455
78MAP2K60.58801827
79CDC70.58058394
80GRK10.56285155
81EIF2AK30.56178915
82BRD40.56142274
83HIPK20.54842653
84JAK20.53596984
85ATR0.53566341
86MAPK110.53328102
87MAP3K110.52947880
88MAPK40.50007425
89RPS6KB20.47812487
90GRK70.47504506
91NUAK10.47124882
92PINK10.46464715
93MATK0.46060738
94CDK190.45503711
95CDK90.42678365
96CDK120.42228060
97NEK90.42222960
98MAPK120.41544399
99EIF2AK10.40953754
100MAP3K70.39789595
101TSSK60.38989867
102NEK20.38425565
103RPS6KA50.37432986
104DYRK30.36374672
105MELK0.36241622
106PASK0.33820560
107ADRBK10.33013914
108PRKD20.32908894
109IGF1R0.32784982
110SRPK10.32719806
111MAPK130.30828961
112MAPK30.30688150
113PDK10.30198965
114TRPM70.29763643
115PRKCD0.29532132
116EIF2AK20.29413271
117FYN0.28617246
118ABL10.28038304
119RPS6KA60.27955801
120MAP3K120.26808591
121MAPKAPK20.25851285
122INSR0.25553237
123FGR0.22947235
124SCYL20.22863601
125EGFR0.20618942
126TRIM280.19620446
127CDC42BPA0.19083968

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.43575813
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.70182361
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.51731625
4B cell receptor signaling pathway_Homo sapiens_hsa046622.44034026
5Measles_Homo sapiens_hsa051622.43957504
6DNA replication_Homo sapiens_hsa030302.38100211
7T cell receptor signaling pathway_Homo sapiens_hsa046602.37853787
8Antigen processing and presentation_Homo sapiens_hsa046122.37768851
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37643279
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.30111513
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30015862
12Hematopoietic cell lineage_Homo sapiens_hsa046402.28550354
13Graft-versus-host disease_Homo sapiens_hsa053322.25798043
14Mismatch repair_Homo sapiens_hsa034302.22982166
15Allograft rejection_Homo sapiens_hsa053302.17611784
16Non-homologous end-joining_Homo sapiens_hsa034502.09910112
17Leishmaniasis_Homo sapiens_hsa051402.05052906
18Ribosome_Homo sapiens_hsa030101.94374082
19Osteoclast differentiation_Homo sapiens_hsa043801.82853424
20Herpes simplex infection_Homo sapiens_hsa051681.81713424
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81650889
22Base excision repair_Homo sapiens_hsa034101.73920567
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.49570420
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49560663
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38236677
26Homologous recombination_Homo sapiens_hsa034401.34634343
27Influenza A_Homo sapiens_hsa051641.34555160
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31017079
29Autoimmune thyroid disease_Homo sapiens_hsa053201.23486508
30Hepatitis B_Homo sapiens_hsa051611.21576067
31Nucleotide excision repair_Homo sapiens_hsa034201.19485121
32Acute myeloid leukemia_Homo sapiens_hsa052211.19157887
33Legionellosis_Homo sapiens_hsa051341.17206397
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16041963
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14553002
36Spliceosome_Homo sapiens_hsa030401.13277026
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11564827
38Toxoplasmosis_Homo sapiens_hsa051451.08386895
39Type I diabetes mellitus_Homo sapiens_hsa049401.08261536
40Viral myocarditis_Homo sapiens_hsa054161.08249567
41Chemokine signaling pathway_Homo sapiens_hsa040621.06873378
42Pertussis_Homo sapiens_hsa051331.05527589
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05300418
44Shigellosis_Homo sapiens_hsa051311.03444438
45Tuberculosis_Homo sapiens_hsa051520.99806394
46Asthma_Homo sapiens_hsa053100.99074559
47Epstein-Barr virus infection_Homo sapiens_hsa051690.98806053
48Apoptosis_Homo sapiens_hsa042100.96147257
49Fanconi anemia pathway_Homo sapiens_hsa034600.91841875
50RNA degradation_Homo sapiens_hsa030180.90669483
51TNF signaling pathway_Homo sapiens_hsa046680.89995947
52Malaria_Homo sapiens_hsa051440.87202283
53HTLV-I infection_Homo sapiens_hsa051660.86890537
54Other glycan degradation_Homo sapiens_hsa005110.86677000
55Platelet activation_Homo sapiens_hsa046110.86237626
56Staphylococcus aureus infection_Homo sapiens_hsa051500.85306214
57Chronic myeloid leukemia_Homo sapiens_hsa052200.83367386
58Pyrimidine metabolism_Homo sapiens_hsa002400.82908605
59p53 signaling pathway_Homo sapiens_hsa041150.82266727
60Viral carcinogenesis_Homo sapiens_hsa052030.82259979
61* Leukocyte transendothelial migration_Homo sapiens_hsa046700.82174961
62Pancreatic cancer_Homo sapiens_hsa052120.79622014
63Systemic lupus erythematosus_Homo sapiens_hsa053220.79308697
64RNA polymerase_Homo sapiens_hsa030200.78532598
65Cell cycle_Homo sapiens_hsa041100.75606567
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75147061
67Colorectal cancer_Homo sapiens_hsa052100.69730193
68Hepatitis C_Homo sapiens_hsa051600.69256148
69Salmonella infection_Homo sapiens_hsa051320.68466177
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67536282
71Phototransduction_Homo sapiens_hsa047440.66794054
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64181182
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60402427
74Basal transcription factors_Homo sapiens_hsa030220.60123847
75African trypanosomiasis_Homo sapiens_hsa051430.59832529
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58917434
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58872373
78Proteasome_Homo sapiens_hsa030500.55345648
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54739437
80Linoleic acid metabolism_Homo sapiens_hsa005910.51948907
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50050725
82Rheumatoid arthritis_Homo sapiens_hsa053230.49600022
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48597048
84Non-small cell lung cancer_Homo sapiens_hsa052230.48511260
85Caffeine metabolism_Homo sapiens_hsa002320.45230785
86Prolactin signaling pathway_Homo sapiens_hsa049170.44469878
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43046551
88Notch signaling pathway_Homo sapiens_hsa043300.42474360
89Small cell lung cancer_Homo sapiens_hsa052220.42353199
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.40731880
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38477536
92RNA transport_Homo sapiens_hsa030130.38148924
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37012936
94mRNA surveillance pathway_Homo sapiens_hsa030150.37010266
95Olfactory transduction_Homo sapiens_hsa047400.36961118
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36845905
97ABC transporters_Homo sapiens_hsa020100.36576315
98Dorso-ventral axis formation_Homo sapiens_hsa043200.36283429
99Thyroid cancer_Homo sapiens_hsa052160.36187323
100FoxO signaling pathway_Homo sapiens_hsa040680.35401703
101Regulation of autophagy_Homo sapiens_hsa041400.33740132
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33685578
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.32890934
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29772020
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27124729
106MAPK signaling pathway_Homo sapiens_hsa040100.26486145
107Arachidonic acid metabolism_Homo sapiens_hsa005900.24882064
108Pentose phosphate pathway_Homo sapiens_hsa000300.24056637
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23899198
110Purine metabolism_Homo sapiens_hsa002300.23593598
111Inositol phosphate metabolism_Homo sapiens_hsa005620.23561371
112Protein export_Homo sapiens_hsa030600.23103911
113N-Glycan biosynthesis_Homo sapiens_hsa005100.22836662
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.22809046
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22146549
116Lysosome_Homo sapiens_hsa041420.21530161
117VEGF signaling pathway_Homo sapiens_hsa043700.18936878
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.15587166
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14078965
120Peroxisome_Homo sapiens_hsa041460.13702027
121Phagosome_Homo sapiens_hsa041450.12850511
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12181697
123Ether lipid metabolism_Homo sapiens_hsa005650.11462816
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09753100
125Insulin resistance_Homo sapiens_hsa049310.09025875
126Glycerolipid metabolism_Homo sapiens_hsa005610.08768054

Most similar genes based on co-expression Upload to Enrichr

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