RHOQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.07409812
2muscle organ morphogenesis (GO:0048644)4.84413349
3muscle filament sliding (GO:0030049)4.51338602
4actin-myosin filament sliding (GO:0033275)4.51338602
5carnitine shuttle (GO:0006853)4.12376094
6regulation of skeletal muscle contraction (GO:0014819)4.09149617
7actin-mediated cell contraction (GO:0070252)3.92384014
8sarcomere organization (GO:0045214)3.84199291
9fatty acid transmembrane transport (GO:1902001)3.75078301
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.70285837
11protein heterotrimerization (GO:0070208)3.66608758
12phospholipid scrambling (GO:0017121)3.60425998
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.59709587
14cellular response to epinephrine stimulus (GO:0071872)3.55840055
15cardiac myofibril assembly (GO:0055003)3.49671185
16sarcoplasmic reticulum calcium ion transport (GO:0070296)3.43990750
17collagen fibril organization (GO:0030199)3.39176291
18myofibril assembly (GO:0030239)3.38618333
19negative regulation of fatty acid transport (GO:2000192)3.38338276
20regulation of the force of heart contraction (GO:0002026)3.36287393
21apoptotic cell clearance (GO:0043277)3.31551669
22actin filament-based movement (GO:0030048)3.30834500
23cardiac muscle hypertrophy (GO:0003300)3.28807155
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.28645988
25response to epinephrine (GO:0071871)3.27516056
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.26897558
27striated muscle hypertrophy (GO:0014897)3.13750290
28regulation of sequestering of triglyceride (GO:0010889)3.11796736
29barbed-end actin filament capping (GO:0051016)3.11558185
30positive regulation of receptor recycling (GO:0001921)3.09944284
31regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.09761628
32regulation of fatty acid oxidation (GO:0046320)3.08266136
33negative regulation of potassium ion transmembrane transport (GO:1901380)3.04382504
34tricarboxylic acid cycle (GO:0006099)3.04105822
35positive regulation of fatty acid oxidation (GO:0046321)3.03845402
36vascular endothelial growth factor signaling pathway (GO:0038084)3.03603200
37cell migration involved in heart development (GO:0060973)3.02086784
38response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.01032974
39cellular response to thyroid hormone stimulus (GO:0097067)2.95862161
40regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94459344
41muscle hypertrophy (GO:0014896)2.94178740
42positive regulation of macrophage cytokine production (GO:0060907)2.92949704
43chondrocyte proliferation (GO:0035988)2.92839763
44response to inactivity (GO:0014854)2.92445913
45carnitine transmembrane transport (GO:1902603)2.91031063
46positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.87377780
47cardiac muscle tissue morphogenesis (GO:0055008)2.87277335
48regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.84715195
49actomyosin structure organization (GO:0031032)2.82882178
50skeletal muscle contraction (GO:0003009)2.82808773
51retina vasculature morphogenesis in camera-type eye (GO:0061299)2.82644548
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82494712
53regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.79619690
54skeletal muscle adaptation (GO:0043501)2.78388377
55heart contraction (GO:0060047)2.76567575
56heart process (GO:0003015)2.76567575
57positive regulation of fatty acid beta-oxidation (GO:0032000)2.75177831
58regulation of p38MAPK cascade (GO:1900744)2.74951875
59detection of molecule of bacterial origin (GO:0032490)2.74675643
60endodermal cell differentiation (GO:0035987)2.74555489
61intracellular lipid transport (GO:0032365)2.73967502
62cell adhesion mediated by integrin (GO:0033627)2.73848641
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73488435
64positive regulation of histone deacetylation (GO:0031065)2.73221697
65muscle tissue morphogenesis (GO:0060415)2.73055954
66regulation of macrophage cytokine production (GO:0010935)2.72369783
67regulation of cell communication by electrical coupling (GO:0010649)2.71739829
68low-density lipoprotein particle clearance (GO:0034383)2.71040912
69insulin-like growth factor receptor signaling pathway (GO:0048009)2.69959956
70positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.69808176
71response to activity (GO:0014823)2.67339045
72cardiac muscle contraction (GO:0060048)2.66743675
73positive regulation of chemokine biosynthetic process (GO:0045080)2.63495482
74amino-acid betaine transport (GO:0015838)2.62473844
75carnitine transport (GO:0015879)2.62473844
76regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62322190
77activation of protein kinase A activity (GO:0034199)2.61848810
78cellular response to vitamin (GO:0071295)2.61319681
79positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.60699087
80ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.59678965
81striated muscle contraction (GO:0006941)2.59395492
82regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.58031621
83NADH metabolic process (GO:0006734)2.57937903
84positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.57925225
85regulation of membrane protein ectodomain proteolysis (GO:0051043)2.57792487
86positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.55767838
87negative regulation of T-helper cell differentiation (GO:0045623)2.54464725
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.54464725
89positive regulation of glycogen biosynthetic process (GO:0045725)2.54044635
90collagen metabolic process (GO:0032963)2.51341862
91muscle system process (GO:0003012)2.50115737
92adult heart development (GO:0007512)2.48336415
93regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.48274205
94epithelial cell-cell adhesion (GO:0090136)2.46667668
95regulation of acyl-CoA biosynthetic process (GO:0050812)2.46295765
96protein localization to endosome (GO:0036010)2.45879444
97response to muscle activity (GO:0014850)2.45244219
98collagen catabolic process (GO:0030574)2.45185921
99positive regulation of myotube differentiation (GO:0010831)2.44934476
100positive regulation of lipid storage (GO:0010884)2.44214101
101regulation of necroptotic process (GO:0060544)2.43555305
102stress fiber assembly (GO:0043149)2.43513766
103regulation of actin filament-based movement (GO:1903115)2.42612219
104multicellular organismal macromolecule metabolic process (GO:0044259)2.41597914
105positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.41305364
106pyrimidine ribonucleoside catabolic process (GO:0046133)2.39659347
107regulation of cholesterol storage (GO:0010885)2.39386735
108positive regulation of p38MAPK cascade (GO:1900745)2.39183929
109muscle contraction (GO:0006936)2.38696849
110growth hormone receptor signaling pathway (GO:0060396)2.38676975
111response to peptidoglycan (GO:0032494)2.38347312
112striated muscle atrophy (GO:0014891)2.37633305
113cardiac muscle cell development (GO:0055013)2.37288582
114protein hydroxylation (GO:0018126)2.36488163
115heart trabecula formation (GO:0060347)2.36321956
116regulation of tight junction assembly (GO:2000810)2.36106971
117axon extension involved in axon guidance (GO:0048846)2.35907469
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.35907469
119regulation of early endosome to late endosome transport (GO:2000641)2.35811690
120regulation of coenzyme metabolic process (GO:0051196)2.35334639
121regulation of cofactor metabolic process (GO:0051193)2.35334639
122negative regulation of heart growth (GO:0061117)2.33728721
123negative regulation of cardiac muscle tissue growth (GO:0055022)2.33728721
124multicellular organismal metabolic process (GO:0044236)2.33614810
125relaxation of cardiac muscle (GO:0055119)2.33523547
126regulation of striated muscle contraction (GO:0006942)2.32947107
127creatine metabolic process (GO:0006600)2.31980757
128negative regulation of necroptotic process (GO:0060546)2.31827264
129regulation of relaxation of muscle (GO:1901077)2.31684357
130basement membrane organization (GO:0071711)2.31050478
131cardiac cell development (GO:0055006)2.31041149
132sequestering of extracellular ligand from receptor (GO:0035581)2.31012857
133skeletal muscle fiber development (GO:0048741)2.30713803
134negative regulation of cell size (GO:0045792)2.30654152
135keratan sulfate catabolic process (GO:0042340)2.30567307
136phagocytosis, recognition (GO:0006910)2.29825964
137modulation by symbiont of host immune response (GO:0052553)2.28706533
138positive regulation by symbiont of host defense response (GO:0052509)2.28706533
139modulation by symbiont of host defense response (GO:0052031)2.28706533
140modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.28706533
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.28706533
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.28706533
143positive regulation of blood vessel endothelial cell migration (GO:0043536)2.28653954
144macrophage activation involved in immune response (GO:0002281)2.28308732
145cellular response to monoamine stimulus (GO:0071868)2.26818733
146cellular response to catecholamine stimulus (GO:0071870)2.26818733
147cGMP-mediated signaling (GO:0019934)2.26770564
148germinal center formation (GO:0002467)2.25471381
149regulation of mononuclear cell migration (GO:0071675)2.24936493
150negative regulation of interleukin-12 production (GO:0032695)2.24710240
151cell communication by electrical coupling (GO:0010644)2.24008366
152neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.22940031
153regulation of cardiac muscle contraction (GO:0055117)2.19195402
154adhesion of symbiont to host cell (GO:0044650)2.19151924
155virion attachment to host cell (GO:0019062)2.19151924
156muscle hypertrophy in response to stress (GO:0003299)2.17488265
157cardiac muscle adaptation (GO:0014887)2.17488265
158cardiac muscle hypertrophy in response to stress (GO:0014898)2.17488265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.48840579
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.27847456
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.79536859
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.60649363
5CLOCK_20551151_ChIP-Seq_293T_Human3.09420322
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.93412788
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.66608734
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58678767
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.23180008
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.18198541
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14434903
12CJUN_26792858_Chip-Seq_BT549_Human2.09934776
13ZNF263_19887448_ChIP-Seq_K562_Human2.07389617
14WT1_19549856_ChIP-ChIP_CCG9911_Human1.97370648
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.96428065
16NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.93801546
17NRF2_20460467_ChIP-Seq_MEFs_Mouse1.93801546
18* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.91713698
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87943244
20* TBX20_22328084_ChIP-Seq_HEART_Mouse1.87136738
21* TBX20_22080862_ChIP-Seq_HEART_Mouse1.87136738
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.85583659
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85353244
24* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.84570885
25* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84513952
26* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.80622607
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.79584360
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77589601
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.77455369
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74711289
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72544997
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71786070
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.70493182
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.68709928
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59256432
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54270963
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.53628573
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.50695311
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46033650
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46022597
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45755903
42GATA1_22025678_ChIP-Seq_K562_Human1.45374846
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42618596
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37701450
45* SOX2_20726797_ChIP-Seq_SW620_Human1.36580120
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34716276
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32110743
48MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31302961
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29939416
50VDR_24787735_ChIP-Seq_THP-1_Human1.29264014
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.28055108
52* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27702254
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26817949
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25889778
55BRD4_25478319_ChIP-Seq_HGPS_Human1.24581600
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24095192
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24077480
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24077480
59PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23882701
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.23661013
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21090387
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21090387
63ZNF274_21170338_ChIP-Seq_K562_Hela1.20450974
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19878336
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18421870
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.18182711
67* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16459027
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16418340
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.16320648
70SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15915436
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15446239
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14414897
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14108604
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13680826
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13412749
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12602204
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12231354
78TP53_18474530_ChIP-ChIP_U2OS_Human1.11357134
79* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11053012
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10311875
81* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08901867
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.07637671
83* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05940658
84* SPI1_23127762_ChIP-Seq_K562_Human1.04812415
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.04763241
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04007821
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03541617
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02760529
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.02729646
90* PU_27001747_Chip-Seq_BMDM_Mouse1.02166549
91RXR_22108803_ChIP-Seq_LS180_Human1.01595822
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01463173
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01115592
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01026805
95RUNX_20019798_ChIP-Seq_JUKART_Human1.00813666
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00427884
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00311264
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99030910
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98603814
100* ATF3_27146783_Chip-Seq_COLON_Human0.98286114
101RUNX1_27514584_Chip-Seq_MCF-7_Human0.97468605
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97423722
103FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96955117
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96867663
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96694041
106KDM2B_26808549_Chip-Seq_DND41_Human0.95899981
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95817659
108DROSHA_22980978_ChIP-Seq_HELA_Human0.94968502
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93958219
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93943648
111KDM2B_26808549_Chip-Seq_K562_Human0.93615996
112* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93081908
113TP53_16413492_ChIP-PET_HCT116_Human0.92884959
114AHR_22903824_ChIP-Seq_MCF-7_Human0.92809018
115GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92355142
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92233059
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91948745
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91223409
119MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90818471
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90708369
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90191153
122* TP63_23658742_ChIP-Seq_EP156T_Human0.90040180
123* RACK7_27058665_Chip-Seq_MCF-7_Human0.88993187
124GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88720461
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88641196
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88119484
127VDR_24763502_ChIP-Seq_THP-1_Human0.87242522
128TCF7_22412390_ChIP-Seq_EML_Mouse0.86664066
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86459073
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.86341807
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84902784
132FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84602398
133TP53_20018659_ChIP-ChIP_R1E_Mouse0.84281858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.63498381
2MP0005275_abnormal_skin_tensile3.31710960
3MP0002837_dystrophic_cardiac_calcinosis3.21928153
4MP0000751_myopathy3.18778006
5MP0003705_abnormal_hypodermis_morpholog2.91199651
6MP0000749_muscle_degeneration2.80909718
7MP0004130_abnormal_muscle_cell2.75904977
8MP0004084_abnormal_cardiac_muscle2.75317217
9MP0005503_abnormal_tendon_morphology2.56439181
10MP0003646_muscle_fatigue2.48947365
11MP0004087_abnormal_muscle_fiber2.38400464
12MP0003279_aneurysm2.30236358
13MP0004145_abnormal_muscle_electrophysio2.28481817
14MP0004036_abnormal_muscle_relaxation2.27961591
15MP0002332_abnormal_exercise_endurance2.24002723
16MP0000750_abnormal_muscle_regeneration2.19812734
17MP0005666_abnormal_adipose_tissue2.14593245
18MP0005330_cardiomyopathy2.11294118
19MP0005623_abnormal_meninges_morphology2.08643849
20MP0001958_emphysema2.08531428
21MP0004272_abnormal_basement_membrane2.07978458
22MP0000759_abnormal_skeletal_muscle2.06247543
23MP0004185_abnormal_adipocyte_glucose2.04984285
24MP0005620_abnormal_muscle_contractility2.01631355
25MP0003566_abnormal_cell_adhesion2.00007189
26MP0003303_peritoneal_inflammation1.96972305
27MP0005670_abnormal_white_adipose1.93318384
28MP0000747_muscle_weakness1.88538548
29MP0000733_abnormal_muscle_development1.87504578
30MP0001348_abnormal_lacrimal_gland1.84059575
31MP0002106_abnormal_muscle_physiology1.81797016
32MP0005451_abnormal_body_composition1.77529968
33MP0000013_abnormal_adipose_tissue1.74660272
34MP0005375_adipose_tissue_phenotype1.71168947
35MP0003724_increased_susceptibility_to1.66534077
36MP0002972_abnormal_cardiac_muscle1.66412434
37MP0004215_abnormal_myocardial_fiber1.66320054
38MP0005369_muscle_phenotype1.64192921
39MP0010630_abnormal_cardiac_muscle1.61095928
40MP0003950_abnormal_plasma_membrane1.60084991
41MP0004484_altered_response_of1.56647667
42MP0004510_myositis1.55573230
43MP0002108_abnormal_muscle_morphology1.51380307
44MP0008775_abnormal_heart_ventricle1.48808745
45MP0006138_congestive_heart_failure1.38555475
46MP0004233_abnormal_muscle_weight1.38519612
47MP0009384_cardiac_valve_regurgitation1.37251025
48MP0001299_abnormal_eye_distance/1.36687944
49MP0005385_cardiovascular_system_phenoty1.34662613
50MP0001544_abnormal_cardiovascular_syste1.34662613
51MP0003690_abnormal_glial_cell1.33029893
52MP0001879_abnormal_lymphatic_vessel1.28971113
53MP0003191_abnormal_cellular_cholesterol1.28430074
54MP0000003_abnormal_adipose_tissue1.27860368
55MP0005257_abnormal_intraocular_pressure1.27407248
56MP0003221_abnormal_cardiomyocyte_apopto1.26873056
57MP0002269_muscular_atrophy1.26551085
58MP0002971_abnormal_brown_adipose1.25486465
59MP0003300_gastrointestinal_ulcer1.20788276
60MP0003828_pulmonary_edema1.18464897
61MP0002877_abnormal_melanocyte_morpholog1.16915339
62MP0002896_abnormal_bone_mineralization1.16514008
63MP0002127_abnormal_cardiovascular_syste1.16271630
64MP0009780_abnormal_chondrocyte_physiolo1.13656222
65MP0003091_abnormal_cell_migration1.13469747
66MP0002295_abnormal_pulmonary_circulatio1.13141642
67MP0003045_fibrosis1.12989042
68MP0003172_abnormal_lysosome_physiology1.12588789
69MP0002060_abnormal_skin_morphology1.11264757
70MP0009840_abnormal_foam_cell1.10395318
71MP0005058_abnormal_lysosome_morphology1.10325261
72MP0000767_abnormal_smooth_muscle1.09050228
73MP0000343_altered_response_to1.06748327
74MP0006054_spinal_hemorrhage1.06094304
75MP0004858_abnormal_nervous_system1.04983473
76MP0005508_abnormal_skeleton_morphology1.04857700
77MP0001533_abnormal_skeleton_physiology1.03958934
78MP0009250_abnormal_appendicular_skeleto1.03852404
79MP0003436_decreased_susceptibility_to1.02901530
80MP0002419_abnormal_innate_immunity0.99984652
81MP0005165_increased_susceptibility_to0.94813727
82MP0003075_altered_response_to0.94237361
83MP0005595_abnormal_vascular_smooth0.93087075
84MP0003448_altered_tumor_morphology0.90849431
85MP0005409_darkened_coat_color0.90664829
86MP0010234_abnormal_vibrissa_follicle0.89763080
87MP0010368_abnormal_lymphatic_system0.89643107
88MP0008260_abnormal_autophagy0.85430609
89MP0005167_abnormal_blood-brain_barrier0.82995611
90MP0000604_amyloidosis0.81577028
91MP0003137_abnormal_impulse_conducting0.81250635
92MP0003385_abnormal_body_wall0.79320917
93MP0009785_altered_susceptibility_to0.78875196
94MP0005023_abnormal_wound_healing0.78520056
95MP0008004_abnormal_stomach_pH0.78184786
96MP0002148_abnormal_hypersensitivity_rea0.78014070
97MP0002128_abnormal_blood_circulation0.77510395
98MP0005166_decreased_susceptibility_to0.77043825
99MP0004883_abnormal_blood_vessel0.74720677
100MP0000249_abnormal_blood_vessel0.74576683
101MP0002998_abnormal_bone_remodeling0.74447166
102MP0009115_abnormal_fat_cell0.73749204
103MP0005164_abnormal_response_to0.73664941
104MP0000428_abnormal_craniofacial_morphol0.70586093
105MP0005388_respiratory_system_phenotype0.70429916
106MP0002133_abnormal_respiratory_system0.70429916
107MP0001177_atelectasis0.70261308
108MP0001542_abnormal_bone_strength0.70141758
109MP0000858_altered_metastatic_potential0.69655176
110MP0000266_abnormal_heart_morphology0.66908115
111MP0006082_CNS_inflammation0.66360207
112MP0002115_abnormal_skeleton_extremities0.65824514
113MP0005076_abnormal_cell_differentiation0.65047473
114MP0005197_abnormal_uvea_morphology0.64912300
115MP0002168_other_aberrant_phenotype0.63631804
116MP0000163_abnormal_cartilage_morphology0.63575786
117MP0010352_gastrointestinal_tract_polyps0.62076601
118MP0004085_abnormal_heartbeat0.61519757
119MP0005390_skeleton_phenotype0.61453618
120MP0005334_abnormal_fat_pad0.61049042
121MP0005171_absent_coat_pigmentation0.60701628
122MP0000534_abnormal_ureter_morphology0.59050382
123MP0004134_abnormal_chest_morphology0.57798031
124MP0003948_abnormal_gas_homeostasis0.57674899

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)4.94654897
2Exercise-induced muscle cramps (HP:0003710)4.65122786
3Protrusio acetabuli (HP:0003179)4.44252167
4Premature rupture of membranes (HP:0001788)4.40372903
5Myoglobinuria (HP:0002913)4.35021595
6Muscle fiber splitting (HP:0003555)4.23914496
7Increased connective tissue (HP:0009025)4.14124816
8Muscle fiber inclusion bodies (HP:0100299)4.08157220
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.04795181
10Exercise-induced myalgia (HP:0003738)3.97380327
11Hyporeflexia of lower limbs (HP:0002600)3.77225449
12Difficulty running (HP:0009046)3.72532816
13Calf muscle hypertrophy (HP:0008981)3.60003733
14Round ear (HP:0100830)3.51840469
15Muscle hypertrophy of the lower extremities (HP:0008968)3.48862281
16Distal arthrogryposis (HP:0005684)3.45695416
17Nemaline bodies (HP:0003798)3.44526471
18Centrally nucleated skeletal muscle fibers (HP:0003687)3.42928839
19Increased variability in muscle fiber diameter (HP:0003557)3.41944510
20Abnormality of the calf musculature (HP:0001430)3.41655160
21Sudden death (HP:0001699)3.31218168
22Asymmetric septal hypertrophy (HP:0001670)3.30404990
23Abnormality of skeletal muscle fiber size (HP:0012084)3.28296072
24Cerebral aneurysm (HP:0004944)3.27349270
25Aortic dissection (HP:0002647)3.11475176
26EMG: myopathic abnormalities (HP:0003458)3.11118134
27Broad metatarsal (HP:0001783)3.10572765
28Spinal rigidity (HP:0003306)3.06699423
29Aortic aneurysm (HP:0004942)2.96531130
30Abnormality of glycolipid metabolism (HP:0010969)2.93898177
31Abnormality of liposaccharide metabolism (HP:0010968)2.93898177
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.93898177
33Difficulty climbing stairs (HP:0003551)2.92977056
34Ankle contracture (HP:0006466)2.91458225
35Right ventricular cardiomyopathy (HP:0011663)2.90675109
36Shallow orbits (HP:0000586)2.89297673
37Mildly elevated creatine phosphokinase (HP:0008180)2.83509197
38Scapular winging (HP:0003691)2.83066846
39Atrial fibrillation (HP:0005110)2.78679548
40Atrophic scars (HP:0001075)2.64261174
41Lipoatrophy (HP:0100578)2.63491805
42Ulnar deviation of the wrist (HP:0003049)2.60705406
43Calcaneovalgus deformity (HP:0001848)2.59515378
44Primary atrial arrhythmia (HP:0001692)2.57432265
45Subaortic stenosis (HP:0001682)2.57345625
46Abnormality of the left ventricular outflow tract (HP:0011103)2.57345625
47Myotonia (HP:0002486)2.50253388
48Rhabdomyolysis (HP:0003201)2.49450729
49Deformed tarsal bones (HP:0008119)2.48935117
50EMG: neuropathic changes (HP:0003445)2.47453536
51Atrioventricular block (HP:0001678)2.46862171
52Ventricular tachycardia (HP:0004756)2.43261908
53Prolonged QT interval (HP:0001657)2.42382713
54Supraventricular arrhythmia (HP:0005115)2.40972661
55Bundle branch block (HP:0011710)2.39557765
56Abnormality of the foot musculature (HP:0001436)2.39378064
57Frequent falls (HP:0002359)2.39207168
58Supraventricular tachycardia (HP:0004755)2.38699261
59Dilatation of the ascending aorta (HP:0005111)2.36635349
60Fragile skin (HP:0001030)2.35325710
61Soft skin (HP:0000977)2.32009094
62Absent phalangeal crease (HP:0006109)2.28685012
63Hypoplastic ischia (HP:0003175)2.28289895
64Foot dorsiflexor weakness (HP:0009027)2.27432758
65Myopathic facies (HP:0002058)2.26709019
66Abnormal atrioventricular conduction (HP:0005150)2.25567089
67Mitral valve prolapse (HP:0001634)2.25256078
68Muscle stiffness (HP:0003552)2.23836621
69Vascular tortuosity (HP:0004948)2.23046225
70Bladder diverticulum (HP:0000015)2.22355003
71Slender build (HP:0001533)2.19901822
72Rimmed vacuoles (HP:0003805)2.19201557
73Wormian bones (HP:0002645)2.18584707
74Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15264510
75Peritonitis (HP:0002586)2.15174999
76Myocardial infarction (HP:0001658)2.11896265
77Progressive muscle weakness (HP:0003323)2.10808650
78Heart block (HP:0012722)2.10333641
79Cervical subluxation (HP:0003308)2.07426057
80Palpitations (HP:0001962)2.07159350
81Facial diplegia (HP:0001349)2.05046042
82Arterial tortuosity (HP:0005116)2.03427885
83Blue sclerae (HP:0000592)2.01160669
84Systemic lupus erythematosus (HP:0002725)2.00643939
85Abnormality of dentin (HP:0010299)2.00502028
86Abnormality of the ischium (HP:0003174)1.99421190
87Gowers sign (HP:0003391)1.99321762
88Areflexia of lower limbs (HP:0002522)1.98585845
89Dilated cardiomyopathy (HP:0001644)1.97356557
90Osteolytic defects of the hand bones (HP:0009699)1.97197887
91Osteolytic defects of the phalanges of the hand (HP:0009771)1.97197887
92Spondylolisthesis (HP:0003302)1.96598054
93Ventricular arrhythmia (HP:0004308)1.95644130
94Aneurysm (HP:0002617)1.95463004
95Skin nodule (HP:0200036)1.94717341
96Abnormal finger flexion creases (HP:0006143)1.94097345
97Distal lower limb amyotrophy (HP:0008944)1.92442761
98Vertebral compression fractures (HP:0002953)1.92316118
99Bulbar palsy (HP:0001283)1.91611842
100Generalized muscle weakness (HP:0003324)1.90989299
101Neck muscle weakness (HP:0000467)1.90624498
102Syncope (HP:0001279)1.90578104
103Axonal loss (HP:0003447)1.90485605
104Distal lower limb muscle weakness (HP:0009053)1.89660624
105Conjunctival hamartoma (HP:0100780)1.88974144
106Eczematoid dermatitis (HP:0000976)1.85345529
107Spontaneous hematomas (HP:0007420)1.85187721
108Ventricular fibrillation (HP:0001663)1.84538229
109Tarsal synostosis (HP:0008368)1.83686281
110Subacute progressive viral hepatitis (HP:0006572)1.82152228
111Hip contracture (HP:0003273)1.81598717
112Abnormality of the calcaneus (HP:0008364)1.81375010
113Dysostosis multiplex (HP:0000943)1.79541402
114Genu recurvatum (HP:0002816)1.75709738
115Wrist flexion contracture (HP:0001239)1.75235210
116Polycythemia (HP:0001901)1.74641863
117Rectal prolapse (HP:0002035)1.74214310
118Muscular dystrophy (HP:0003560)1.74110268
119Amyloidosis (HP:0011034)1.73606276
120Ragged-red muscle fibers (HP:0003200)1.72014496
121Limb-girdle muscle atrophy (HP:0003797)1.71434311
122Bell-shaped thorax (HP:0001591)1.70854619
123Steppage gait (HP:0003376)1.70829186
124Recurrent gram-negative bacterial infections (HP:0005420)1.70715946
125Neonatal short-limb short stature (HP:0008921)1.70571731
126Abnormal EKG (HP:0003115)1.70231712
127Sudden cardiac death (HP:0001645)1.69985682
128Overgrowth (HP:0001548)1.69937763
129Nuclear cataract (HP:0100018)1.68443219
130Lower limb amyotrophy (HP:0007210)1.67978446
131Abnormality of the endocardium (HP:0004306)1.66116031
132Generalized amyotrophy (HP:0003700)1.64785870
133Mucopolysacchariduria (HP:0008155)1.64332701
134Urinary glycosaminoglycan excretion (HP:0003541)1.64332701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.86326135
2TTN4.67396782
3PKN23.06140977
4OBSCN2.93256631
5PHKG12.35227234
6PHKG22.35227234
7DDR22.34397177
8PRPF4B2.27895288
9PDGFRA2.23624683
10DMPK2.20765825
11SIK12.12223029
12PDK22.11258882
13LMTK22.09413361
14CAMK1D2.03224625
15RIPK12.02205951
16NEK91.90662151
17PDK41.86430450
18PDK31.86430450
19PIK3CA1.82993566
20LATS11.77812758
21ERN11.61861838
22FRK1.58631884
23MAP3K61.56355258
24BLK1.54299394
25GRK71.53596897
26MAP3K131.49992557
27MYLK1.49949559
28FER1.48885228
29TGFBR21.46719497
30TRPM71.46274522
31TYK21.45890540
32PTK61.45040902
33IRAK31.39383797
34ILK1.39322863
35CAMK1G1.39077312
36ROCK11.35749704
37MAP3K141.33909897
38BMX1.32238513
39RIPK41.29222317
40MUSK1.28465783
41CSK1.24696218
42PAK31.23265778
43LRRK21.13175571
44LATS21.08214401
45BCKDK1.07813905
46PIK3CG1.06267415
47ZAP701.04854930
48CDK91.04014300
49MAPK71.01674744
50PINK10.98103659
51PRKD10.95347301
52TAOK20.93689727
53EPHB20.93312322
54PRKCH0.93220161
55FGFR30.90695640
56MST1R0.89063745
57JAK10.87544111
58PAK20.87387748
59KIT0.85975067
60PDGFRB0.85513408
61PRKAA20.81922763
62MAPK40.81575677
63MAP2K10.80434920
64EPHA30.79753452
65RET0.79728364
66ERBB30.79624549
67MAP3K10.79291842
68MOS0.77151008
69EPHB10.75643523
70MET0.73373181
71PAK40.73195461
72MAP3K70.72384612
73PTK20.71330494
74MAP2K30.70993450
75JAK30.70842602
76MARK20.70791403
77FGFR40.69906950
78CDK60.68424039
79CAMK10.67697512
80STK240.67324842
81LIMK10.66915278
82WNK10.66625529
83MAP3K50.64907538
84JAK20.64061447
85MAPKAPK30.63617838
86CAMK2D0.60836680
87ABL20.60295116
88NTRK10.59591292
89PAK60.59032691
90FGR0.58967696
91IRAK40.58095845
92CDC42BPA0.57704958
93KSR10.57148740
94STK30.56972217
95SGK20.55780049
96RPS6KC10.55567030
97RPS6KL10.55567030
98ROCK20.55266615
99PDPK10.55071370
100CAMK40.54393970
101TAOK10.52111764
102STK380.50724870
103NEK10.50292343
104MAP3K30.50138311
105FGFR10.48616069
106PTK2B0.48428090
107DYRK1B0.48328217
108TBK10.48296877
109PRKD30.48178936
110DAPK30.48001820
111MAP2K40.47821327
112MAPK120.47449465
113MTOR0.47322261
114EEF2K0.47044255
115RPS6KA20.46990196
116CHUK0.46786815
117MAP3K20.46428381
118KSR20.44781494
119PRKD20.44607451
120CAMKK10.44497749
121WNK40.44363312
122INSR0.42029970
123MAP3K100.41458785
124TESK10.41233211
125CAMK2G0.40592454
126STK38L0.40418613
127PRKCE0.40173888
128ICK0.39572808
129PRKG20.38697331
130MARK30.38658391
131BMPR20.37763618
132RPS6KA60.36195469
133FGFR20.36129926
134PRKAA10.35528304
135NLK0.35510732
136PRKG10.34959144
137STK390.33011963
138SRC0.32749482
139GSK3A0.32376612
140ABL10.31663066
141IGF1R0.31365751
142SGK30.30662063
143PDK10.29546554

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.51881638
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.56920705
3Dilated cardiomyopathy_Homo sapiens_hsa054142.53702925
4ECM-receptor interaction_Homo sapiens_hsa045122.16076758
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.12138660
6Focal adhesion_Homo sapiens_hsa045102.03518562
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.99739416
8Propanoate metabolism_Homo sapiens_hsa006401.95787048
9Other glycan degradation_Homo sapiens_hsa005111.80744732
10Fatty acid biosynthesis_Homo sapiens_hsa000611.76986902
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73233561
12Fatty acid degradation_Homo sapiens_hsa000711.60536622
13Fatty acid metabolism_Homo sapiens_hsa012121.58021060
14Proteoglycans in cancer_Homo sapiens_hsa052051.53149239
15Adipocytokine signaling pathway_Homo sapiens_hsa049201.51615384
16Staphylococcus aureus infection_Homo sapiens_hsa051501.51037682
17Amoebiasis_Homo sapiens_hsa051461.44721052
18Insulin resistance_Homo sapiens_hsa049311.42962527
19* Insulin signaling pathway_Homo sapiens_hsa049101.41554852
20Cardiac muscle contraction_Homo sapiens_hsa042601.40685016
21Viral myocarditis_Homo sapiens_hsa054161.38805876
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37897817
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34025908
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.33234889
25Adherens junction_Homo sapiens_hsa045201.29655349
26PPAR signaling pathway_Homo sapiens_hsa033201.26739294
27Protein digestion and absorption_Homo sapiens_hsa049741.17234534
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14077704
29AMPK signaling pathway_Homo sapiens_hsa041521.13414252
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09971783
31Pertussis_Homo sapiens_hsa051331.09971493
32B cell receptor signaling pathway_Homo sapiens_hsa046621.09336130
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08867461
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07823082
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.05247472
36Carbon metabolism_Homo sapiens_hsa012001.03912425
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.03449919
38Circadian rhythm_Homo sapiens_hsa047101.02377962
39Malaria_Homo sapiens_hsa051441.01331391
40Glucagon signaling pathway_Homo sapiens_hsa049220.99416493
41Prion diseases_Homo sapiens_hsa050200.95563824
42Lysosome_Homo sapiens_hsa041420.94801655
43Platelet activation_Homo sapiens_hsa046110.93858684
44Chronic myeloid leukemia_Homo sapiens_hsa052200.93352544
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92844441
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91374338
47Tight junction_Homo sapiens_hsa045300.91308804
48Toxoplasmosis_Homo sapiens_hsa051450.88993791
49HIF-1 signaling pathway_Homo sapiens_hsa040660.88242195
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88112130
51Small cell lung cancer_Homo sapiens_hsa052220.87951856
52Type II diabetes mellitus_Homo sapiens_hsa049300.87216132
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86031682
54Leishmaniasis_Homo sapiens_hsa051400.86001849
55Acute myeloid leukemia_Homo sapiens_hsa052210.85267402
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85098112
57Starch and sucrose metabolism_Homo sapiens_hsa005000.84916848
58Chemokine signaling pathway_Homo sapiens_hsa040620.83123318
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80537430
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80517720
61Glioma_Homo sapiens_hsa052140.80448440
62Osteoclast differentiation_Homo sapiens_hsa043800.79965868
63Rheumatoid arthritis_Homo sapiens_hsa053230.79564240
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77990746
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77482443
66Melanoma_Homo sapiens_hsa052180.76965014
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75633923
68Oxytocin signaling pathway_Homo sapiens_hsa049210.75353427
69Complement and coagulation cascades_Homo sapiens_hsa046100.72122746
70Renin secretion_Homo sapiens_hsa049240.72117858
71Pyruvate metabolism_Homo sapiens_hsa006200.71747495
72Renal cell carcinoma_Homo sapiens_hsa052110.70818192
73mTOR signaling pathway_Homo sapiens_hsa041500.69704449
74Pancreatic cancer_Homo sapiens_hsa052120.69240728
75Long-term potentiation_Homo sapiens_hsa047200.69029528
76Phagosome_Homo sapiens_hsa041450.68035904
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.67318752
78Bladder cancer_Homo sapiens_hsa052190.66964029
79Influenza A_Homo sapiens_hsa051640.66382983
80FoxO signaling pathway_Homo sapiens_hsa040680.65770679
81Asthma_Homo sapiens_hsa053100.65248372
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65196087
83TNF signaling pathway_Homo sapiens_hsa046680.63936689
84Salmonella infection_Homo sapiens_hsa051320.63836501
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63545096
86Non-small cell lung cancer_Homo sapiens_hsa052230.62138857
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.61888503
88MicroRNAs in cancer_Homo sapiens_hsa052060.61037267
89Olfactory transduction_Homo sapiens_hsa047400.60763604
90Rap1 signaling pathway_Homo sapiens_hsa040150.60756972
91VEGF signaling pathway_Homo sapiens_hsa043700.60716121
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60252306
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.59819906
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.58539509
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57624095
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56162878
97Hippo signaling pathway_Homo sapiens_hsa043900.56132931
98Dorso-ventral axis formation_Homo sapiens_hsa043200.56058159
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55807705
100Tuberculosis_Homo sapiens_hsa051520.55740228
101cAMP signaling pathway_Homo sapiens_hsa040240.55673938
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55592183
103Estrogen signaling pathway_Homo sapiens_hsa049150.55187787
104Hepatitis C_Homo sapiens_hsa051600.55175473
105Calcium signaling pathway_Homo sapiens_hsa040200.55169774
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54934451
107Gap junction_Homo sapiens_hsa045400.54375905
108Gastric acid secretion_Homo sapiens_hsa049710.53713622
109Endometrial cancer_Homo sapiens_hsa052130.53282225
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52199374
111Legionellosis_Homo sapiens_hsa051340.51910699
112GnRH signaling pathway_Homo sapiens_hsa049120.51723583
113Caffeine metabolism_Homo sapiens_hsa002320.51049571
114Prolactin signaling pathway_Homo sapiens_hsa049170.50435692
115Prostate cancer_Homo sapiens_hsa052150.50073357
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49651084
117African trypanosomiasis_Homo sapiens_hsa051430.49554506
118Phenylalanine metabolism_Homo sapiens_hsa003600.49025704
119Endocytosis_Homo sapiens_hsa041440.48531904
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.48429426
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47932511
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.47658545
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47319519
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47204247
125TGF-beta signaling pathway_Homo sapiens_hsa043500.47175716
126Measles_Homo sapiens_hsa051620.45663439
127Hepatitis B_Homo sapiens_hsa051610.45166719
128Parkinsons disease_Homo sapiens_hsa050120.44203172
129Allograft rejection_Homo sapiens_hsa053300.43793230
130Melanogenesis_Homo sapiens_hsa049160.43394156
131MAPK signaling pathway_Homo sapiens_hsa040100.43064307
132Alzheimers disease_Homo sapiens_hsa050100.43037410

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