RHOQP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)7.40678875
2protein localization to chromosome, centromeric region (GO:0071459)6.89866305
3mitotic chromosome condensation (GO:0007076)5.99027606
4DNA unwinding involved in DNA replication (GO:0006268)5.86680771
5attachment of spindle microtubules to kinetochore (GO:0008608)5.51536306
6nuclear pore complex assembly (GO:0051292)5.45685572
7DNA topological change (GO:0006265)5.23622924
8nuclear pore organization (GO:0006999)5.19555417
9mitotic metaphase plate congression (GO:0007080)5.18585153
10mitotic sister chromatid segregation (GO:0000070)4.99834722
11sister chromatid segregation (GO:0000819)4.95103914
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.88939229
13establishment of integrated proviral latency (GO:0075713)4.78364306
14regulation of DNA endoreduplication (GO:0032875)4.71069181
15protein localization to microtubule (GO:0035372)4.66229786
16microtubule cytoskeleton organization involved in mitosis (GO:1902850)4.38722695
17metaphase plate congression (GO:0051310)4.32080821
18regulation of centriole replication (GO:0046599)4.29757346
19DNA strand elongation involved in DNA replication (GO:0006271)4.25215476
20protein localization to chromosome (GO:0034502)4.19368609
21DNA strand elongation (GO:0022616)4.17486084
22DNA replication checkpoint (GO:0000076)4.13564492
23positive regulation of chromosome segregation (GO:0051984)4.05323411
24DNA ligation (GO:0006266)4.02939571
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.00686249
26chromosome condensation (GO:0030261)3.99641255
27mitotic nuclear envelope disassembly (GO:0007077)3.99555229
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.85232613
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.85232613
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.85232613
31pore complex assembly (GO:0046931)3.84405385
32CENP-A containing nucleosome assembly (GO:0034080)3.81918955
33DNA synthesis involved in DNA repair (GO:0000731)3.80567454
34nuclear envelope disassembly (GO:0051081)3.74043034
35membrane disassembly (GO:0030397)3.74043034
36chromatin remodeling at centromere (GO:0031055)3.69691596
37establishment of chromosome localization (GO:0051303)3.67264494
38establishment of viral latency (GO:0019043)3.66793709
39telomere maintenance via semi-conservative replication (GO:0032201)3.66786779
40DNA packaging (GO:0006323)3.66020846
41DNA replication initiation (GO:0006270)3.64263907
42mitotic sister chromatid cohesion (GO:0007064)3.63574110
43mitotic recombination (GO:0006312)3.62909699
44synapsis (GO:0007129)3.57672974
45telomere maintenance via recombination (GO:0000722)3.51838326
46meiotic chromosome segregation (GO:0045132)3.48744356
47ribosome assembly (GO:0042255)3.48235625
48DNA replication-dependent nucleosome assembly (GO:0006335)3.48026046
49DNA replication-dependent nucleosome organization (GO:0034723)3.48026046
50chromosome segregation (GO:0007059)3.45319118
51histone exchange (GO:0043486)3.43448691
52regulation of centrosome cycle (GO:0046605)3.40425000
53regulation of chromosome segregation (GO:0051983)3.39023384
54DNA conformation change (GO:0071103)3.35439790
55DNA replication-independent nucleosome organization (GO:0034724)3.33884163
56DNA replication-independent nucleosome assembly (GO:0006336)3.33884163
57regulation of mitotic spindle organization (GO:0060236)3.32530344
58formation of translation preinitiation complex (GO:0001731)3.30354270
59kinetochore organization (GO:0051383)3.26950306
60negative regulation of DNA repair (GO:0045738)3.22250546
61ribosomal large subunit biogenesis (GO:0042273)3.21324483
62DNA duplex unwinding (GO:0032508)3.18632576
63microtubule depolymerization (GO:0007019)3.17603174
64regulation of sister chromatid cohesion (GO:0007063)3.16003075
65DNA geometric change (GO:0032392)3.12626281
66protein localization to microtubule cytoskeleton (GO:0072698)3.12541241
67V(D)J recombination (GO:0033151)3.12272747
68non-recombinational repair (GO:0000726)3.11769570
69double-strand break repair via nonhomologous end joining (GO:0006303)3.11769570
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09335270
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09335270
72regulation of centrosome duplication (GO:0010824)3.08471147
73regulation of sister chromatid segregation (GO:0033045)3.07100266
74regulation of mitotic sister chromatid separation (GO:0010965)3.07100266
75regulation of mitotic sister chromatid segregation (GO:0033047)3.07100266
76ATP-dependent chromatin remodeling (GO:0043044)3.05589221
77chromatin assembly or disassembly (GO:0006333)3.05020126
78mitochondrial RNA metabolic process (GO:0000959)3.04911632
79regulation of spindle organization (GO:0090224)3.03920498
80negative regulation of chromosome segregation (GO:0051985)2.98725711
81maturation of SSU-rRNA (GO:0030490)2.94910829
82translesion synthesis (GO:0019985)2.94307391
83regulation of double-strand break repair (GO:2000779)2.94118790
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93230698
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.93230698
86resolution of meiotic recombination intermediates (GO:0000712)2.93179468
87regulation of double-strand break repair via homologous recombination (GO:0010569)2.92820064
88folic acid-containing compound biosynthetic process (GO:0009396)2.91861862
89nuclear envelope organization (GO:0006998)2.91383395
90negative regulation of mitotic sister chromatid separation (GO:2000816)2.88139075
91negative regulation of sister chromatid segregation (GO:0033046)2.88139075
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88139075
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88139075
94negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88139075
95regulation of RNA export from nucleus (GO:0046831)2.85763542
96regulation of transcription from RNA polymerase I promoter (GO:0006356)2.85002941
97protein K6-linked ubiquitination (GO:0085020)2.83202063
98spindle checkpoint (GO:0031577)2.82500854
99chromosome organization involved in meiosis (GO:0070192)2.82190871
100DNA biosynthetic process (GO:0071897)2.81690833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.48121058
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.19554121
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.78202001
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.39029813
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.01701891
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.51946755
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45995320
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02954919
9AR_21909140_ChIP-Seq_LNCAP_Human2.91179165
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82456234
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69017213
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67648349
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66006549
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.60606174
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.59970447
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.58440989
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.53350754
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.52630234
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40622975
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38853761
21DCP1A_22483619_ChIP-Seq_HELA_Human2.29713178
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.21232569
23XRN2_22483619_ChIP-Seq_HELA_Human2.19032462
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17776126
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.17168100
26ELK1_19687146_ChIP-ChIP_HELA_Human2.14882117
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.10738488
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07760334
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98780058
30TTF2_22483619_ChIP-Seq_HELA_Human1.98641231
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93929037
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82705688
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81988477
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76929747
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75277204
36FOXP3_21729870_ChIP-Seq_TREG_Human1.73859953
37VDR_23849224_ChIP-Seq_CD4+_Human1.73264925
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71024829
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70824205
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.68998093
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59894469
42GABP_19822575_ChIP-Seq_HepG2_Human1.58078675
43MYC_22102868_ChIP-Seq_BL_Human1.56562548
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56150770
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55927891
46CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54938035
47KDM5A_27292631_Chip-Seq_BREAST_Human1.52302219
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48766311
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46904356
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46573154
51E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45391650
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.44227702
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39990989
54ZNF263_19887448_ChIP-Seq_K562_Human1.32256586
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30214978
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29662023
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26567899
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24454945
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24073499
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23849839
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22612764
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22259078
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.19131377
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16903246
65TFEB_21752829_ChIP-Seq_HELA_Human1.15183243
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13441290
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13288160
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11338955
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09078142
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06127051
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.04156544
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99426273
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98607551
74STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97998643
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97845610
76MYC_18940864_ChIP-ChIP_HL60_Human0.97454718
77SOX17_20123909_ChIP-Seq_XEN_Mouse0.97443803
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97056115
79CHD1_26751641_Chip-Seq_LNCaP_Human0.96981799
80SRF_21415370_ChIP-Seq_HL-1_Mouse0.91811102
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91290150
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90541455
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88466531
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86523346
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.85697651
86CIITA_25753668_ChIP-Seq_RAJI_Human0.85230291
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83902228
88PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83585039
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.81283199
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79207056
91TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79170568
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76122352
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.75366782
94TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74940780
95ELF5_23300383_ChIP-Seq_T47D_Human0.72836146
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.71261397
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71040557
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70868286
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.68929933
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.66773305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.44643253
2MP0008057_abnormal_DNA_replication4.79429234
3MP0003111_abnormal_nucleus_morphology4.40042948
4MP0004957_abnormal_blastocyst_morpholog4.17593596
5MP0003693_abnormal_embryo_hatching4.12053186
6MP0003077_abnormal_cell_cycle3.93016196
7MP0008058_abnormal_DNA_repair3.80560885
8MP0008007_abnormal_cellular_replicative2.95481345
9MP0008932_abnormal_embryonic_tissue2.60700952
10MP0008877_abnormal_DNA_methylation2.42852795
11MP0000350_abnormal_cell_proliferation2.38456792
12MP0001730_embryonic_growth_arrest2.30092157
13MP0010307_abnormal_tumor_latency2.22456921
14MP0002877_abnormal_melanocyte_morpholog2.21737651
15MP0002396_abnormal_hematopoietic_system2.16149004
16MP0010352_gastrointestinal_tract_polyps2.12074800
17MP0003941_abnormal_skin_development1.93217276
18MP0001697_abnormal_embryo_size1.83922456
19MP0001672_abnormal_embryogenesis/_devel1.82302301
20MP0005380_embryogenesis_phenotype1.82302301
21MP0005076_abnormal_cell_differentiation1.75920462
22MP0002080_prenatal_lethality1.75147283
23MP0003705_abnormal_hypodermis_morpholog1.71799139
24MP0003984_embryonic_growth_retardation1.71738340
25MP0003786_premature_aging1.71644746
26MP0002088_abnormal_embryonic_growth/wei1.68112022
27MP0002009_preneoplasia1.67905786
28MP0003718_maternal_effect1.57917110
29MP0002085_abnormal_embryonic_tissue1.56097036
30MP0000313_abnormal_cell_death1.52595151
31MP0004185_abnormal_adipocyte_glucose1.51802411
32MP0004197_abnormal_fetal_growth/weight/1.51242432
33MP0004808_abnormal_hematopoietic_stem1.49925644
34MP0002084_abnormal_developmental_patter1.47978681
35MP0006035_abnormal_mitochondrial_morpho1.44797888
36MP0002086_abnormal_extraembryonic_tissu1.42860113
37MP0001529_abnormal_vocalization1.41516666
38MP0002210_abnormal_sex_determination1.36603059
39MP0009697_abnormal_copulation1.34309115
40MP0000358_abnormal_cell_content/1.28015859
41MP0001915_intracranial_hemorrhage1.26540218
42MP0008438_abnormal_cutaneous_collagen1.22270690
43MP0009672_abnormal_birth_weight1.20110463
44MP0001929_abnormal_gametogenesis1.19952631
45MP0005501_abnormal_skin_physiology1.13186342
46MP0003566_abnormal_cell_adhesion1.12397510
47MP0005621_abnormal_cell_physiology1.10214307
48MP0004233_abnormal_muscle_weight1.09924759
49MP0005384_cellular_phenotype1.09745864
50MP0002697_abnormal_eye_size1.05990981
51MP0005623_abnormal_meninges_morphology1.05166434
52MP0002060_abnormal_skin_morphology1.03984723
53MP0000428_abnormal_craniofacial_morphol1.02891401
54MP0009379_abnormal_foot_pigmentation1.01448109
55MP0003567_abnormal_fetal_cardiomyocyte1.00339675
56MP0002019_abnormal_tumor_incidence0.99976005
57MP0003937_abnormal_limbs/digits/tail_de0.99084426
58MP0001145_abnormal_male_reproductive0.98942255
59MP0003221_abnormal_cardiomyocyte_apopto0.98763038
60MP0000490_abnormal_crypts_of0.97880367
61MP0002796_impaired_skin_barrier0.97774877
62MP0003950_abnormal_plasma_membrane0.96676215
63MP0000653_abnormal_sex_gland0.91756658
64MP0000733_abnormal_muscle_development0.89226204
65MP0003699_abnormal_female_reproductive0.88640158
66MP0001286_abnormal_eye_development0.88115501
67MP0001849_ear_inflammation0.88042161
68MP0004272_abnormal_basement_membrane0.87344262
69MP0002092_abnormal_eye_morphology0.87258755
70MP0002089_abnormal_postnatal_growth/wei0.83310191
71MP0002166_altered_tumor_susceptibility0.81969762
72MP0001293_anophthalmia0.81730059
73MP0002160_abnormal_reproductive_system0.81297125
74MP0005409_darkened_coat_color0.81236730
75MP0003943_abnormal_hepatobiliary_system0.78058402
76MP0009703_decreased_birth_body0.76925776
77MP0002006_tumorigenesis0.76830642
78MP0003868_abnormal_feces_composition0.75943376
79MP0003385_abnormal_body_wall0.73907671
80MP0003890_abnormal_embryonic-extraembry0.73858894
81MP0002161_abnormal_fertility/fecundity0.72955344
82MP0002111_abnormal_tail_morphology0.70806519
83MP0003959_abnormal_lean_body0.70549640
84MP0003935_abnormal_craniofacial_develop0.69820038
85MP0003698_abnormal_male_reproductive0.69802534
86MP0002234_abnormal_pharynx_morphology0.69134218
87MP0000703_abnormal_thymus_morphology0.68516145
88MP0005408_hypopigmentation0.66457946
89MP0002163_abnormal_gland_morphology0.65522733
90MP0001119_abnormal_female_reproductive0.64361113
91MP0002233_abnormal_nose_morphology0.62563979
92MP0003861_abnormal_nervous_system0.62129914
93MP0000627_abnormal_mammary_gland0.61046641
94MP0001216_abnormal_epidermal_layer0.59171134
95MP0006036_abnormal_mitochondrial_physio0.58741557
96MP0003091_abnormal_cell_migration0.58050310
97MP0002925_abnormal_cardiovascular_devel0.57905407
98MP0001661_extended_life_span0.56981962
99MP0005197_abnormal_uvea_morphology0.55955204
100MP0003755_abnormal_palate_morphology0.55811902

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.62697687
2Chromsome breakage (HP:0040012)4.98609429
3Meckel diverticulum (HP:0002245)3.72953648
4Birth length less than 3rd percentile (HP:0003561)3.55578154
5Abnormality of the ileum (HP:0001549)3.51825136
6Abnormality of chromosome stability (HP:0003220)3.43521959
7Progressive external ophthalmoplegia (HP:0000590)3.41300792
8Abnormality of the preputium (HP:0100587)3.38866576
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.28447069
10Small intestinal stenosis (HP:0012848)3.17123873
11Duodenal stenosis (HP:0100867)3.17123873
12Myelodysplasia (HP:0002863)3.13826433
13Reticulocytopenia (HP:0001896)3.09694877
14Progressive muscle weakness (HP:0003323)2.92492841
15Increased nuchal translucency (HP:0010880)2.86472129
16Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74031260
17Microvesicular hepatic steatosis (HP:0001414)2.68073118
18Abnormality of the carotid arteries (HP:0005344)2.65679639
19Duplicated collecting system (HP:0000081)2.60557897
20Nephroblastoma (Wilms tumor) (HP:0002667)2.58065870
21Abnormal lung lobation (HP:0002101)2.57397783
22Abnormality of the fetal cardiovascular system (HP:0010948)2.57258141
23Abnormal umbilical cord blood vessels (HP:0011403)2.57258141
24Single umbilical artery (HP:0001195)2.57258141
25Increased hepatocellular lipid droplets (HP:0006565)2.51878760
26Septate vagina (HP:0001153)2.48600390
27Embryonal renal neoplasm (HP:0011794)2.43400698
28Squamous cell carcinoma (HP:0002860)2.41715761
29Abnormality of the duodenum (HP:0002246)2.40656192
30Acute myeloid leukemia (HP:0004808)2.40285320
31Aplastic anemia (HP:0001915)2.38985490
32Abnormal foot bone ossification (HP:0010675)2.38800391
33Arteriovenous malformation (HP:0100026)2.35126027
34Lipid accumulation in hepatocytes (HP:0006561)2.34259947
35Clubbing of toes (HP:0100760)2.34004222
36Volvulus (HP:0002580)2.33690689
37Abnormality of the phalanges of the hallux (HP:0010057)2.33536141
38Medulloblastoma (HP:0002885)2.32201271
39Abnormality of DNA repair (HP:0003254)2.28165265
40Cafe-au-lait spot (HP:0000957)2.26848599
41Abnormality of cells of the erythroid lineage (HP:0012130)2.25937975
42Sloping forehead (HP:0000340)2.15217816
43Abnormal number of erythroid precursors (HP:0012131)2.08425105
44Breast hypoplasia (HP:0003187)2.07440780
45Colon cancer (HP:0003003)2.07254342
46Cortical dysplasia (HP:0002539)2.05637790
47Bone marrow hypocellularity (HP:0005528)2.05308197
48Abnormality of the renal collecting system (HP:0004742)2.05163126
49Absent radius (HP:0003974)2.05153554
50Poikiloderma (HP:0001029)2.04844802
51Horizontal nystagmus (HP:0000666)2.04699727
52Syringomyelia (HP:0003396)2.01489761
53Spinal cord lesions (HP:0100561)2.01489761
54Sparse lateral eyebrow (HP:0005338)2.00574182
55Leiomyosarcoma (HP:0100243)1.99018372
56Uterine leiomyosarcoma (HP:0002891)1.99018372
57Abnormality of the anterior horn cell (HP:0006802)1.98352729
58Degeneration of anterior horn cells (HP:0002398)1.98352729
59Ependymoma (HP:0002888)1.97614448
60Rhabdomyosarcoma (HP:0002859)1.95656407
61Ankyloglossia (HP:0010296)1.95402129
62Ureteral duplication (HP:0000073)1.95032294
63Acute lymphatic leukemia (HP:0006721)1.94136478
64Pallor (HP:0000980)1.93370141
65Deviation of the thumb (HP:0009603)1.92237692
66Gastrointestinal carcinoma (HP:0002672)1.92237354
67Malignant gastrointestinal tract tumors (HP:0006749)1.92237354
68Deep philtrum (HP:0002002)1.91844291
69Segmental peripheral demyelination/remyelination (HP:0003481)1.91132641
70Neoplasm of the colon (HP:0100273)1.88501558
71Macrocytic anemia (HP:0001972)1.88050422
72Dyschromatopsia (HP:0007641)1.86987019
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84418777
74Micronodular cirrhosis (HP:0001413)1.83765673
75Abnormality of the umbilical cord (HP:0010881)1.83389097
76Proximal placement of thumb (HP:0009623)1.83251664
77Multiple enchondromatosis (HP:0005701)1.82493779
78Neoplasm of the pancreas (HP:0002894)1.82355981
79Absent forearm bone (HP:0003953)1.80836778
80Aplasia involving forearm bones (HP:0009822)1.80836778
81Low anterior hairline (HP:0000294)1.80636066
82Overlapping toe (HP:0001845)1.80087938
83Microglossia (HP:0000171)1.79456339
84Ectopic kidney (HP:0000086)1.77973459
85Abnormality of homocysteine metabolism (HP:0010919)1.74409549
86Homocystinuria (HP:0002156)1.74409549
87Absent thumb (HP:0009777)1.74034398
88B lymphocytopenia (HP:0010976)1.73534556
89Shoulder girdle muscle weakness (HP:0003547)1.73520233
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.73151242
91Abnormalities of placenta or umbilical cord (HP:0001194)1.73133890
92Atresia of the external auditory canal (HP:0000413)1.72174382
93Missing ribs (HP:0000921)1.72000035
94Duplication of thumb phalanx (HP:0009942)1.70613404
9511 pairs of ribs (HP:0000878)1.69906269
96Abnormality of oral frenula (HP:0000190)1.68220083
97Uterine neoplasm (HP:0010784)1.65428341
98Dysmetric saccades (HP:0000641)1.65104867
99Abnormality of placental membranes (HP:0011409)1.64712188
100Amniotic constriction ring (HP:0009775)1.64712188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.63553523
2NEK13.46245171
3EIF2AK33.25357786
4BUB13.08937840
5TTK2.84114256
6MAP3K122.82038617
7SRPK12.68516058
8WEE12.47885181
9TSSK62.31964129
10MAP3K102.21777228
11MKNK22.04035729
12CDK122.03503474
13EIF2AK12.02141139
14PLK41.95491132
15VRK21.93006371
16MKNK11.89846199
17BRSK21.78496015
18TAF11.75749042
19CHEK21.74996111
20IRAK31.70178484
21PBK1.68341049
22ZAK1.66411449
23PLK31.64540404
24PLK11.59803509
25SMG11.58998001
26VRK11.58706725
27STK161.57387163
28LATS21.56127426
29CDK81.52801492
30BRD41.50043434
31DYRK31.49692144
32CDK71.43187765
33EIF2AK21.38229555
34CHEK11.32487960
35NEK21.25242342
36CDK41.23948962
37BRSK11.22947485
38AURKB1.22730115
39TRIB31.17166128
40ATR1.16845173
41EEF2K1.12862950
42PAK41.11566601
43SCYL21.10546482
44MAP3K81.08090060
45AURKA1.05726270
46CDK61.05520088
47RPS6KA41.03992019
48PDGFRA1.01404608
49MET1.01162175
50BMPR1B0.95913044
51STK40.87600947
52CLK10.84473944
53MAP3K90.79034586
54ALK0.78930370
55RPS6KB20.78690494
56NME20.78209916
57STK30.75054975
58SIK10.74694615
59ATM0.74654818
60MST1R0.71698897
61PRPF4B0.71463384
62PNCK0.70576527
63BRAF0.68678404
64MTOR0.67164379
65ERBB40.66979007
66CCNB10.65670138
67CDK10.64738298
68CDK20.64520436
69NEK60.61411855
70MELK0.59289299
71CDK90.57925206
72YES10.54563731
73LATS10.54292054
74STK100.53758957
75NEK90.51648363
76PLK20.51333072
77CSNK1E0.51189889
78PAK20.49094764
79KSR20.47384648
80NUAK10.47196818
81PDK20.46476462
82CSNK2A20.45461335
83PKN20.44919972
84RAF10.43583671
85TLK10.41858836
86RPS6KA50.41224783
87CSNK2A10.40977006
88MAPK110.39713652
89ICK0.38749427
90CSNK1G10.37298518
91TRIM280.37255627
92PRKCI0.35618205
93AKT20.33155469
94TGFBR10.30255037
95CAMK1G0.29894503
96PASK0.29871227
97MAPK140.28765956
98ABL20.27305223
99CDK11A0.27298091
100STK240.26881633

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.52314419
2Mismatch repair_Homo sapiens_hsa034303.85054685
3Cell cycle_Homo sapiens_hsa041103.32265055
4Non-homologous end-joining_Homo sapiens_hsa034503.31292686
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.29938048
6Spliceosome_Homo sapiens_hsa030403.19417777
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11049179
8Nucleotide excision repair_Homo sapiens_hsa034203.10517236
9RNA transport_Homo sapiens_hsa030132.86166812
10Homologous recombination_Homo sapiens_hsa034402.77692207
11Base excision repair_Homo sapiens_hsa034102.74521562
12Fanconi anemia pathway_Homo sapiens_hsa034602.45470538
13Ribosome_Homo sapiens_hsa030102.14984388
14Basal transcription factors_Homo sapiens_hsa030222.14370030
15One carbon pool by folate_Homo sapiens_hsa006702.01543045
16Protein export_Homo sapiens_hsa030601.88179639
17Proteasome_Homo sapiens_hsa030501.88104289
18mRNA surveillance pathway_Homo sapiens_hsa030151.83984301
19Selenocompound metabolism_Homo sapiens_hsa004501.71561377
20Pyrimidine metabolism_Homo sapiens_hsa002401.66220161
21RNA polymerase_Homo sapiens_hsa030201.64398458
22RNA degradation_Homo sapiens_hsa030181.53536092
23p53 signaling pathway_Homo sapiens_hsa041151.46675534
24Viral carcinogenesis_Homo sapiens_hsa052031.27131832
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22230523
26Sulfur relay system_Homo sapiens_hsa041221.20988035
27Systemic lupus erythematosus_Homo sapiens_hsa053221.20206217
28Folate biosynthesis_Homo sapiens_hsa007901.18216998
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15388364
30Small cell lung cancer_Homo sapiens_hsa052221.15147819
31Thyroid cancer_Homo sapiens_hsa052161.09928507
32Bladder cancer_Homo sapiens_hsa052191.08792058
33Alcoholism_Homo sapiens_hsa050341.04482874
34Chronic myeloid leukemia_Homo sapiens_hsa052201.03230243
35Pyruvate metabolism_Homo sapiens_hsa006201.00855605
36Oocyte meiosis_Homo sapiens_hsa041141.00725936
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00504524
38MicroRNAs in cancer_Homo sapiens_hsa052061.00418433
39Purine metabolism_Homo sapiens_hsa002300.99990030
40Pancreatic cancer_Homo sapiens_hsa052120.91021382
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85721427
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.85055136
43Biosynthesis of amino acids_Homo sapiens_hsa012300.84472784
44Epstein-Barr virus infection_Homo sapiens_hsa051690.82617378
45Non-small cell lung cancer_Homo sapiens_hsa052230.77643162
46Huntingtons disease_Homo sapiens_hsa050160.75217445
47N-Glycan biosynthesis_Homo sapiens_hsa005100.73143496
48Lysine degradation_Homo sapiens_hsa003100.72723734
49TGF-beta signaling pathway_Homo sapiens_hsa043500.68988070
50Steroid biosynthesis_Homo sapiens_hsa001000.68210243
51Vitamin B6 metabolism_Homo sapiens_hsa007500.68137542
52Colorectal cancer_Homo sapiens_hsa052100.67137585
53Prostate cancer_Homo sapiens_hsa052150.62381515
54Melanoma_Homo sapiens_hsa052180.62256674
55Carbon metabolism_Homo sapiens_hsa012000.60941114
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60231603
57Hepatitis B_Homo sapiens_hsa051610.59420614
58HTLV-I infection_Homo sapiens_hsa051660.58958076
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.58237650
60Pentose phosphate pathway_Homo sapiens_hsa000300.57417445
61Hippo signaling pathway_Homo sapiens_hsa043900.56600647
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56524064
63Glioma_Homo sapiens_hsa052140.53297466
64Adherens junction_Homo sapiens_hsa045200.52376433
65Parkinsons disease_Homo sapiens_hsa050120.52138768
66Renal cell carcinoma_Homo sapiens_hsa052110.49819671
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48271555
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45148752
69Apoptosis_Homo sapiens_hsa042100.45136536
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44980021
71Pathways in cancer_Homo sapiens_hsa052000.41157402
72Proteoglycans in cancer_Homo sapiens_hsa052050.40767081
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40053230
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39525792
75Shigellosis_Homo sapiens_hsa051310.34572004
76Endometrial cancer_Homo sapiens_hsa052130.33884113
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33183657
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32837211
79Gap junction_Homo sapiens_hsa045400.32830948
80mTOR signaling pathway_Homo sapiens_hsa041500.30642543
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28824808
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27396790
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26967064
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25793501
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24546393
86Acute myeloid leukemia_Homo sapiens_hsa052210.24062329
87Wnt signaling pathway_Homo sapiens_hsa043100.23833988
88Herpes simplex infection_Homo sapiens_hsa051680.23109783
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22718324
90ErbB signaling pathway_Homo sapiens_hsa040120.22111813
91Oxidative phosphorylation_Homo sapiens_hsa001900.21879667
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21846279
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19328158
94FoxO signaling pathway_Homo sapiens_hsa040680.17754053
95HIF-1 signaling pathway_Homo sapiens_hsa040660.17568274
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17284650
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17019885
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15508735
99Focal adhesion_Homo sapiens_hsa045100.15333999
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14507660

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