RHOQP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)8.25241275
2glomerular filtration (GO:0003094)7.44800596
3glomerular basement membrane development (GO:0032836)7.16323722
4neuron fate determination (GO:0048664)6.67304350
5regulation of cardioblast proliferation (GO:0003264)6.61773105
6regulation of secondary heart field cardioblast proliferation (GO:0003266)6.61773105
7renal filtration (GO:0097205)6.56381282
8nephron epithelium morphogenesis (GO:0072088)6.49922064
9nephron tubule morphogenesis (GO:0072078)6.49922064
10neuronal stem cell maintenance (GO:0097150)6.30340644
11protein localization to microtubule (GO:0035372)5.72337755
12spermatid nucleus differentiation (GO:0007289)5.67423942
13regulation of timing of cell differentiation (GO:0048505)5.58853625
14radial glial cell differentiation (GO:0060019)5.55941274
15regulation of organ formation (GO:0003156)5.51021616
16chondrocyte development (GO:0002063)5.36397162
17innervation (GO:0060384)5.30600086
18cell morphogenesis involved in neuron differentiation (GO:0048667)5.17662655
19regulation of development, heterochronic (GO:0040034)5.10357469
20ventricular septum development (GO:0003281)5.08166092
21otic vesicle formation (GO:0030916)4.93155260
22negative regulation of oligodendrocyte differentiation (GO:0048715)4.77908429
23renal tubule morphogenesis (GO:0061333)4.73843648
24negative regulation of epidermal cell differentiation (GO:0045605)4.51188060
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37236310
26negative regulation of embryonic development (GO:0045992)4.34069882
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.24056289
28positive regulation of astrocyte differentiation (GO:0048711)4.20537094
29negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.01938256
30protein localization to kinetochore (GO:0034501)4.00161257
31cardiac septum development (GO:0003279)3.97882649
32negative regulation of axon guidance (GO:1902668)3.95412350
33microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.85214631
34positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.83374569
35regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.83374569
36tongue development (GO:0043586)3.83303500
37positive regulation of embryonic development (GO:0040019)3.82485557
38attachment of spindle microtubules to kinetochore (GO:0008608)3.80196799
39cell-cell signaling involved in cell fate commitment (GO:0045168)3.72794316
40retinal ganglion cell axon guidance (GO:0031290)3.71710488
41ovulation from ovarian follicle (GO:0001542)3.70084765
42negative regulation of glial cell proliferation (GO:0060253)3.67648789
43regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.64326396
44dopaminergic neuron differentiation (GO:0071542)3.62403439
45ventricular septum morphogenesis (GO:0060412)3.61927968
46negative regulation of glial cell differentiation (GO:0045686)3.61247372
47positive regulation of BMP signaling pathway (GO:0030513)3.57064903
48centriole replication (GO:0007099)3.56978214
49regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.54037041
50positive regulation of gastrulation (GO:2000543)3.53114622
51protein localization to microtubule cytoskeleton (GO:0072698)3.44285832
52heparan sulfate proteoglycan metabolic process (GO:0030201)3.43467692
53endocrine pancreas development (GO:0031018)3.41764607
54cranial nerve development (GO:0021545)3.41127273
55type B pancreatic cell development (GO:0003323)3.41117107
56embryonic skeletal system development (GO:0048706)3.34266322
57regulation of synapse structural plasticity (GO:0051823)3.33853127
58epithelial cilium movement (GO:0003351)3.28870789
59lateral sprouting from an epithelium (GO:0060601)3.26759516
60positive regulation vascular endothelial growth factor production (GO:0010575)3.23392458
61negative regulation of epidermis development (GO:0045683)3.17321563
62cytidine metabolic process (GO:0046087)3.16179355
63cytidine catabolic process (GO:0006216)3.16179355
64cytidine deamination (GO:0009972)3.16179355
65forebrain neuron differentiation (GO:0021879)3.10777968
66protein localization to cytoskeleton (GO:0044380)3.05906712
67telencephalon development (GO:0021537)3.00880454
68regulation of hexokinase activity (GO:1903299)3.00289094
69regulation of glucokinase activity (GO:0033131)3.00289094
70positive regulation of glial cell differentiation (GO:0045687)2.98712530
71positive regulation of Notch signaling pathway (GO:0045747)2.97524936
72protein polyglutamylation (GO:0018095)2.94209857
73hematopoietic stem cell proliferation (GO:0071425)2.93677584
74behavioral response to nicotine (GO:0035095)2.92217460
75negative regulation of reproductive process (GO:2000242)2.90050774
76respiratory electron transport chain (GO:0022904)2.88969320
77electron transport chain (GO:0022900)2.86338715
78primitive streak formation (GO:0090009)2.86088032
79negative regulation of activin receptor signaling pathway (GO:0032926)2.86028093
80dermatan sulfate biosynthetic process (GO:0030208)2.84402140
81negative regulation of axon extension (GO:0030517)2.83553194
82hindbrain development (GO:0030902)2.82922737
83startle response (GO:0001964)2.81903333
84DNA deamination (GO:0045006)2.78587930
85positive regulation of meiosis (GO:0045836)2.76164717
86bone development (GO:0060348)2.74365305
87glandular epithelial cell development (GO:0002068)2.71774659
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69662464
89mitotic cell cycle arrest (GO:0071850)2.66676450
90regulation of vascular endothelial growth factor production (GO:0010574)2.65212024
91regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64640193
92protein localization to chromosome, centromeric region (GO:0071459)2.64549732
93regulation of stem cell maintenance (GO:2000036)2.62909447
94maturation of SSU-rRNA (GO:0030490)2.62131872
95neuron cell-cell adhesion (GO:0007158)2.61534485
96positive regulation of meiotic cell cycle (GO:0051446)2.60282163
97regulation of heart morphogenesis (GO:2000826)2.60005074
98positive regulation of neuroblast proliferation (GO:0002052)2.58727327
99cochlea development (GO:0090102)2.57820006
100dopamine biosynthetic process (GO:0042416)2.56466335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse6.65486597
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.59462879
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02909624
4GBX2_23144817_ChIP-Seq_PC3_Human2.70564136
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.68389238
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.66764901
7TAF15_26573619_Chip-Seq_HEK293_Human2.54279645
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49997343
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43321429
10EZH2_22144423_ChIP-Seq_EOC_Human2.41977005
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.41917252
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34283686
13VDR_22108803_ChIP-Seq_LS180_Human2.32610499
14RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.31255016
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.29561406
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24353760
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.16476241
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05983276
19P300_19829295_ChIP-Seq_ESCs_Human2.04736729
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01358639
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97232573
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.95233558
23ZNF274_21170338_ChIP-Seq_K562_Hela1.95179781
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94639750
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.94413961
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86498813
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.86089288
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84742432
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79735116
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.79364097
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.76450555
32BCAT_22108803_ChIP-Seq_LS180_Human1.74282886
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74209000
34RNF2_27304074_Chip-Seq_NSC_Mouse1.73978697
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71402095
36GATA1_22025678_ChIP-Seq_K562_Human1.69750008
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69567729
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.68398685
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62389906
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62389906
41FUS_26573619_Chip-Seq_HEK293_Human1.60809855
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57361557
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.56793375
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53416791
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52042871
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49368740
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48976315
48EWS_26573619_Chip-Seq_HEK293_Human1.48302649
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.48088988
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.42974336
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42923406
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42607299
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38160049
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36710503
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36085493
56TBX3_20139965_ChIP-Seq_MESCs_Mouse1.35556641
57AR_21572438_ChIP-Seq_LNCaP_Human1.34288456
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32797017
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32228748
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.31450761
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27904310
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.27854943
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26812003
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26629256
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26220688
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26220688
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26059779
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25889312
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24283828
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21176512
71CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20545854
72SOX2_19829295_ChIP-Seq_ESCs_Human1.20524306
73NANOG_19829295_ChIP-Seq_ESCs_Human1.20524306
74AR_25329375_ChIP-Seq_VCAP_Human1.19882034
75SMAD4_21799915_ChIP-Seq_A2780_Human1.19360019
76REST_21632747_ChIP-Seq_MESCs_Mouse1.18904191
77SOX9_26525672_Chip-Seq_HEART_Mouse1.18783846
78KDM2B_26808549_Chip-Seq_REH_Human1.17516425
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17497291
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15822544
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15588797
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14173129
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13142381
84LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12936178
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12818393
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12818393
87ER_23166858_ChIP-Seq_MCF-7_Human1.12654391
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.12500648
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10329900
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.05583364
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.03116721
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.02915096
93MYC_18940864_ChIP-ChIP_HL60_Human1.02389355
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.02146815
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00197164
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99754932
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98594683
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98265919
99SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96045782
100STAT3_23295773_ChIP-Seq_U87_Human0.95485150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.07237605
2MP0002653_abnormal_ependyma_morphology4.80809147
3MP0002139_abnormal_hepatobiliary_system3.96931686
4MP0005084_abnormal_gallbladder_morpholo3.92557799
5MP0000569_abnormal_digit_pigmentation3.33589342
6MP0000467_abnormal_esophagus_morphology2.74379992
7MP0004142_abnormal_muscle_tone2.64842398
8MP0002928_abnormal_bile_duct2.55072691
9MP0000631_abnormal_neuroendocrine_gland2.09213216
10MP0008995_early_reproductive_senescence2.04358377
11MP0006072_abnormal_retinal_apoptosis2.01802260
12MP0003950_abnormal_plasma_membrane1.92906560
13MP0002277_abnormal_respiratory_mucosa1.89248122
14MP0004145_abnormal_muscle_electrophysio1.88296861
15MP0002751_abnormal_autonomic_nervous1.85130779
16MP0002932_abnormal_joint_morphology1.82516464
17MP0000013_abnormal_adipose_tissue1.79348567
18MP0004742_abnormal_vestibular_system1.76511266
19MP0000534_abnormal_ureter_morphology1.74144624
20MP0003942_abnormal_urinary_system1.69635347
21MP0002282_abnormal_trachea_morphology1.69358910
22MP0003011_delayed_dark_adaptation1.67515204
23MP0001984_abnormal_olfaction1.59752433
24MP0000749_muscle_degeneration1.57319538
25MP0003122_maternal_imprinting1.51716135
26MP0008789_abnormal_olfactory_epithelium1.50208972
27MP0000026_abnormal_inner_ear1.48138285
28MP0002837_dystrophic_cardiac_calcinosis1.47606341
29MP0000778_abnormal_nervous_system1.44224166
30MP0002822_catalepsy1.43257032
31MP0005499_abnormal_olfactory_system1.41521740
32MP0005394_taste/olfaction_phenotype1.41521740
33MP0004215_abnormal_myocardial_fiber1.40487968
34MP0003121_genomic_imprinting1.40126087
35MP0009053_abnormal_anal_canal1.29739186
36MP0002138_abnormal_hepatobiliary_system1.29124207
37MP0000751_myopathy1.26894460
38MP0001663_abnormal_digestive_system1.25989459
39MP0003890_abnormal_embryonic-extraembry1.25971908
40MP0004133_heterotaxia1.25666213
41MP0002234_abnormal_pharynx_morphology1.21001931
42MP0003646_muscle_fatigue1.20602716
43MP0005551_abnormal_eye_electrophysiolog1.20426545
44MP0008877_abnormal_DNA_methylation1.18230554
45MP0005174_abnormal_tail_pigmentation1.14940324
46MP0000383_abnormal_hair_follicle1.14937603
47MP0002332_abnormal_exercise_endurance1.13114548
48MP0002102_abnormal_ear_morphology1.12611276
49MP0001529_abnormal_vocalization1.10609427
50MP0000566_synostosis1.10217023
51MP0001286_abnormal_eye_development1.09236237
52MP0005379_endocrine/exocrine_gland_phen1.07423479
53MP0005645_abnormal_hypothalamus_physiol1.07002136
54MP0000427_abnormal_hair_cycle1.05266077
55MP0002064_seizures1.05252681
56MP0000955_abnormal_spinal_cord1.04770890
57MP0009046_muscle_twitch1.04230876
58MP0005381_digestive/alimentary_phenotyp1.02099249
59MP0003329_amyloid_beta_deposits0.98024651
60MP0005195_abnormal_posterior_eye0.96816011
61MP0003806_abnormal_nucleotide_metabolis0.96313684
62MP0009379_abnormal_foot_pigmentation0.96282622
63MP0002163_abnormal_gland_morphology0.96044349
64MP0001486_abnormal_startle_reflex0.95341782
65MP0002272_abnormal_nervous_system0.94778156
66MP0005253_abnormal_eye_physiology0.91978846
67MP0002733_abnormal_thermal_nociception0.91731866
68MP0002938_white_spotting0.90363081
69MP0005171_absent_coat_pigmentation0.90349421
70MP0000371_diluted_coat_color0.89289705
71MP0001293_anophthalmia0.86985970
72MP0002067_abnormal_sensory_capabilities0.86363532
73MP0005503_abnormal_tendon_morphology0.86186967
74MP0003632_abnormal_nervous_system0.85387849
75MP0002734_abnormal_mechanical_nocicepti0.84064380
76MP0008770_decreased_survivor_rate0.83284820
77MP0002106_abnormal_muscle_physiology0.83070264
78MP0002160_abnormal_reproductive_system0.82614904
79MP0001485_abnormal_pinna_reflex0.82426315
80MP0009745_abnormal_behavioral_response0.82048717
81MP0001905_abnormal_dopamine_level0.81551267
82MP0006035_abnormal_mitochondrial_morpho0.81092680
83MP0002736_abnormal_nociception_after0.80611909
84MP0005508_abnormal_skeleton_morphology0.80337417
85MP0002095_abnormal_skin_pigmentation0.79418533
86MP0002572_abnormal_emotion/affect_behav0.79274019
87MP0002752_abnormal_somatic_nervous0.79063076
88MP0001944_abnormal_pancreas_morphology0.79031824
89MP0002249_abnormal_larynx_morphology0.77834190
90MP0003635_abnormal_synaptic_transmissio0.75863193
91MP0002882_abnormal_neuron_morphology0.75090757
92MP0006292_abnormal_olfactory_placode0.74789069
93MP0002111_abnormal_tail_morphology0.74042352
94MP0005620_abnormal_muscle_contractility0.71693829
95MP0000750_abnormal_muscle_regeneration0.71118382
96MP0001970_abnormal_pain_threshold0.69159880
97MP0003880_abnormal_central_pattern0.67961041
98MP0005369_muscle_phenotype0.67524612
99MP0000163_abnormal_cartilage_morphology0.66163432
100MP0002063_abnormal_learning/memory/cond0.66092090

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.63909849
2Synostosis involving bones of the lower limbs (HP:0009138)4.50612125
3Synostosis involving bones of the feet (HP:0009140)4.50612125
4Abnormality of incisor morphology (HP:0011063)4.36674690
5Tarsal synostosis (HP:0008368)4.13345567
6Bilateral sensorineural hearing impairment (HP:0008619)4.08935900
7Pancreatic cysts (HP:0001737)3.93192811
8True hermaphroditism (HP:0010459)3.77008110
9Pancreatic fibrosis (HP:0100732)3.69255164
10Large for gestational age (HP:0001520)3.68625489
11Rib fusion (HP:0000902)3.63386711
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.60187128
13Carpal synostosis (HP:0009702)3.59237417
14Molar tooth sign on MRI (HP:0002419)3.55729675
15Abnormality of midbrain morphology (HP:0002418)3.55729675
16Absent/shortened dynein arms (HP:0200106)3.51880689
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.51880689
18Progressive cerebellar ataxia (HP:0002073)3.40203945
19Absent septum pellucidum (HP:0001331)3.34398294
20Limb dystonia (HP:0002451)3.13625132
21Impulsivity (HP:0100710)3.11569082
22Synostosis involving bones of the hand (HP:0004278)3.10285617
23Gait imbalance (HP:0002141)3.07002478
24Sclerocornea (HP:0000647)3.06764816
25Abnormality of the septum pellucidum (HP:0007375)3.02505910
26Acute necrotizing encephalopathy (HP:0006965)2.97986829
27Maternal diabetes (HP:0009800)2.93772894
28Synostosis of carpal bones (HP:0005048)2.86129889
29Central scotoma (HP:0000603)2.79572006
30Congenital primary aphakia (HP:0007707)2.75114054
31Medial flaring of the eyebrow (HP:0010747)2.73180354
32Mitochondrial inheritance (HP:0001427)2.70043286
33Nephronophthisis (HP:0000090)2.69682362
34Esophageal atresia (HP:0002032)2.66579038
35Abnormality of the incisor (HP:0000676)2.62812807
36Ulnar deviation of finger (HP:0009465)2.61446207
37Progressive macrocephaly (HP:0004481)2.57134407
38Abnormality of the fovea (HP:0000493)2.55968728
39Optic nerve hypoplasia (HP:0000609)2.54962622
40Genetic anticipation (HP:0003743)2.53514560
41Gastrointestinal atresia (HP:0002589)2.53175570
42Nephrogenic diabetes insipidus (HP:0009806)2.51065426
43Abnormal mitochondria in muscle tissue (HP:0008316)2.48268866
44Scanning speech (HP:0002168)2.48012856
45Acute encephalopathy (HP:0006846)2.44392892
46Cystic liver disease (HP:0006706)2.43658878
47Increased hepatocellular lipid droplets (HP:0006565)2.42594823
48Short metatarsal (HP:0010743)2.41525226
49Congenital, generalized hypertrichosis (HP:0004540)2.39497851
50Abnormality of macular pigmentation (HP:0008002)2.39127374
51Abnormal ciliary motility (HP:0012262)2.37304606
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.36097439
53Anophthalmia (HP:0000528)2.35653766
54Lipid accumulation in hepatocytes (HP:0006561)2.34611301
55Specific learning disability (HP:0001328)2.34286219
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.26107843
57Aplasia/hypoplasia of the uterus (HP:0008684)2.25788419
58Prominent supraorbital ridges (HP:0000336)2.24774838
59Broad foot (HP:0001769)2.22602291
60Calf muscle hypertrophy (HP:0008981)2.22420112
61Carpal bone hypoplasia (HP:0001498)2.22003921
62Hypoplasia of the uterus (HP:0000013)2.20534128
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19780196
64Abnormal respiratory epithelium morphology (HP:0012253)2.18884109
65Abnormal respiratory motile cilium morphology (HP:0005938)2.18884109
66Vaginal atresia (HP:0000148)2.18110019
67Cerebral inclusion bodies (HP:0100314)2.16683697
68Abnormality of the lower motor neuron (HP:0002366)2.14447282
69Ulnar deviation of the hand or of fingers of the hand (HP:0001193)2.14241355
70Poor coordination (HP:0002370)2.13352572
71Muscle hypertrophy of the lower extremities (HP:0008968)2.10091738
72Anencephaly (HP:0002323)2.10017261
73Supernumerary spleens (HP:0009799)2.08452304
74Abnormality of the upper arm (HP:0001454)2.07638829
75Abnormality of the renal medulla (HP:0100957)2.04879769
76Genital tract atresia (HP:0001827)2.04635289
77Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.04540512
78Hypoplastic ischia (HP:0003175)2.03308056
79Increased CSF lactate (HP:0002490)2.03065462
80Hemivertebrae (HP:0002937)2.02811722
81Scotoma (HP:0000575)1.99108218
82Furrowed tongue (HP:0000221)1.97630367
83Cerebral edema (HP:0002181)1.96795522
84Optic disc pallor (HP:0000543)1.92167156
85Abnormality of the humerus (HP:0003063)1.91798528
86Intestinal atresia (HP:0011100)1.91767551
87Abnormal number of erythroid precursors (HP:0012131)1.89997624
88Bifid tongue (HP:0010297)1.88254351
89Abnormality of the pubic bones (HP:0003172)1.86569629
90Chronic hepatic failure (HP:0100626)1.85788165
91Left ventricular hypertrophy (HP:0001712)1.85532278
92Mesomelia (HP:0003027)1.85264573
93Abnormality of the pons (HP:0007361)1.85225778
94Tubulointerstitial fibrosis (HP:0005576)1.85152364
95Abnormal pancreas size (HP:0012094)1.85002081
96Abnormality of renal resorption (HP:0011038)1.84944627
97Partial duplication of thumb phalanx (HP:0009944)1.83188855
98Abnormal respiratory motile cilium physiology (HP:0012261)1.82288088
99Ankle contracture (HP:0006466)1.82009395
100Abnormality of the ischium (HP:0003174)1.80865962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.86375652
2PHKG13.05624700
3PHKG23.05624700
4BLK3.03107449
5BCKDK2.87915007
6PNCK2.83018659
7TAF12.81083057
8MARK12.63588220
9PINK12.46468686
10MST42.45520430
11SGK22.40593241
12STK38L2.29082571
13ZAK2.24483835
14BMPR1B2.23125482
15OBSCN2.21111970
16STK42.18101948
17ADRBK22.00235720
18NME11.79222203
19IKBKE1.76162106
20SGK2231.72727553
21SGK4941.72727553
22NTRK21.72432397
23DYRK21.57822747
24CDC71.40948993
25CAMK1G1.38119901
26TEC1.34966777
27SGK31.32273130
28WNK11.32159187
29CHUK1.23560616
30WNK31.23250446
31EPHA31.22741995
32GRK11.20577679
33PRKG21.09155229
34CASK1.04799535
35MAPK131.04510819
36PKN11.03042905
37MAPK151.00970496
38MAP3K120.99862367
39CHEK20.97353136
40MKNK20.94587867
41PIM10.93170231
42DAPK20.92926671
43MAP3K90.91044452
44CAMK10.89093365
45PRKAA20.88977119
46MKNK10.88925879
47MAP3K40.88722347
48SIK10.84202726
49PBK0.83695575
50LATS10.82049449
51TAOK10.80518132
52PRKG10.70521308
53EIF2AK20.70344099
54IRAK10.68795653
55TTN0.65757049
56CDK190.65174686
57FRK0.64426431
58MAP2K70.64020122
59STK160.63663153
60STK30.63418711
61CAMK2A0.62339030
62IKBKB0.61477042
63PRKCG0.59263693
64GRK70.59152366
65NLK0.58840631
66PRKACA0.55720622
67ACVR1B0.55384936
68CAMK2B0.50234974
69MAP2K60.49637322
70PRKACB0.49398739
71ADRBK10.46822609
72EPHB20.46787725
73PLK10.46539210
74ROCK10.45404332
75TYRO30.45164982
76MAP2K40.44181197
77PIK3CG0.43611849
78VRK10.42637214
79SGK10.41511349
80RPS6KA30.41477076
81PRKCE0.41277437
82PAK30.40978733
83OXSR10.40147335
84TIE10.39855292
85MAP3K70.39691131
86STK380.39662765
87MAPK120.39609843
88AURKA0.39531780
89MYLK0.36877872
90PTK2B0.36854143
91PRKCZ0.36287695
92WNK40.35912060
93PTK60.34491427
94AKT10.34138426
95CSNK1D0.33908369
96CDK50.32574406
97INSRR0.32358398
98CAMK2D0.32074098
99NUAK10.31331740
100PRKAA10.31309438

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.98185355
2Oxidative phosphorylation_Homo sapiens_hsa001903.96748821
3Parkinsons disease_Homo sapiens_hsa050123.65193014
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.58746347
5Protein export_Homo sapiens_hsa030603.29438408
6Selenocompound metabolism_Homo sapiens_hsa004502.73424241
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.49311741
8Alzheimers disease_Homo sapiens_hsa050102.48981332
9Cardiac muscle contraction_Homo sapiens_hsa042602.37711737
10Huntingtons disease_Homo sapiens_hsa050162.35957094
11Ribosome_Homo sapiens_hsa030102.28508354
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03622969
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02969584
14Taste transduction_Homo sapiens_hsa047421.94037211
15Propanoate metabolism_Homo sapiens_hsa006401.87802209
16Folate biosynthesis_Homo sapiens_hsa007901.66269629
17Nicotine addiction_Homo sapiens_hsa050331.65255791
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44079807
19Hedgehog signaling pathway_Homo sapiens_hsa043401.43705336
20Cocaine addiction_Homo sapiens_hsa050301.39259673
21Butanoate metabolism_Homo sapiens_hsa006501.37088940
22Fanconi anemia pathway_Homo sapiens_hsa034601.35119538
23Linoleic acid metabolism_Homo sapiens_hsa005911.32024487
24Basal cell carcinoma_Homo sapiens_hsa052171.28450139
25beta-Alanine metabolism_Homo sapiens_hsa004101.23449167
26RNA polymerase_Homo sapiens_hsa030201.21800393
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16963048
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16710445
29Tryptophan metabolism_Homo sapiens_hsa003801.15742190
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06684435
31Homologous recombination_Homo sapiens_hsa034401.05286263
32Regulation of autophagy_Homo sapiens_hsa041401.05152658
33RNA degradation_Homo sapiens_hsa030180.99149665
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98340989
35Olfactory transduction_Homo sapiens_hsa047400.90516482
36Pyruvate metabolism_Homo sapiens_hsa006200.88994659
37Serotonergic synapse_Homo sapiens_hsa047260.87119441
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85434621
39GABAergic synapse_Homo sapiens_hsa047270.83260484
40Alcoholism_Homo sapiens_hsa050340.79421794
41Starch and sucrose metabolism_Homo sapiens_hsa005000.77435318
42Nucleotide excision repair_Homo sapiens_hsa034200.76350767
43ABC transporters_Homo sapiens_hsa020100.76349939
44Insulin secretion_Homo sapiens_hsa049110.76204720
45Ether lipid metabolism_Homo sapiens_hsa005650.75864384
46Systemic lupus erythematosus_Homo sapiens_hsa053220.74980116
47Notch signaling pathway_Homo sapiens_hsa043300.74020764
48Dilated cardiomyopathy_Homo sapiens_hsa054140.73335711
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73285975
50Proteasome_Homo sapiens_hsa030500.72613548
51Hippo signaling pathway_Homo sapiens_hsa043900.71890729
52Sulfur relay system_Homo sapiens_hsa041220.71852059
53Dopaminergic synapse_Homo sapiens_hsa047280.71537524
54Morphine addiction_Homo sapiens_hsa050320.71269492
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70720401
56Circadian entrainment_Homo sapiens_hsa047130.68430640
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67803079
58Glutamatergic synapse_Homo sapiens_hsa047240.67611538
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67411977
60Basal transcription factors_Homo sapiens_hsa030220.67348948
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66943106
62Dorso-ventral axis formation_Homo sapiens_hsa043200.66750710
63Ovarian steroidogenesis_Homo sapiens_hsa049130.66355379
64Chemical carcinogenesis_Homo sapiens_hsa052040.64851091
65Histidine metabolism_Homo sapiens_hsa003400.63828179
66Phototransduction_Homo sapiens_hsa047440.63624352
67Axon guidance_Homo sapiens_hsa043600.63083101
68Cholinergic synapse_Homo sapiens_hsa047250.62406968
69TGF-beta signaling pathway_Homo sapiens_hsa043500.59871570
70Oocyte meiosis_Homo sapiens_hsa041140.59766939
71Nitrogen metabolism_Homo sapiens_hsa009100.57203212
72Retinol metabolism_Homo sapiens_hsa008300.54289470
73Amphetamine addiction_Homo sapiens_hsa050310.53581435
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52821837
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52645115
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51847263
77One carbon pool by folate_Homo sapiens_hsa006700.51605072
78Gastric acid secretion_Homo sapiens_hsa049710.49462997
79Calcium signaling pathway_Homo sapiens_hsa040200.49273011
80Long-term depression_Homo sapiens_hsa047300.48457469
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46500697
82Spliceosome_Homo sapiens_hsa030400.46475689
83DNA replication_Homo sapiens_hsa030300.43085062
84Metabolic pathways_Homo sapiens_hsa011000.42109976
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41667123
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39538550
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38668979
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38482031
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.38228443
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37036838
91Synaptic vesicle cycle_Homo sapiens_hsa047210.36411246
92Purine metabolism_Homo sapiens_hsa002300.36358151
93Melanogenesis_Homo sapiens_hsa049160.35754180
94Wnt signaling pathway_Homo sapiens_hsa043100.35562529
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.34869253
96Circadian rhythm_Homo sapiens_hsa047100.33804459
97Oxytocin signaling pathway_Homo sapiens_hsa049210.33285297
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32952993
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32744891
100Salivary secretion_Homo sapiens_hsa049700.32379007

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