ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	8.88507432
2	regulation of acrosome reaction (GO:0060046)	7.28787643
3	acrosome reaction (GO:0007340)	6.22268358
4	protein K11-linked deubiquitination (GO:0035871)	6.05573464
5	regulation of DNA endoreduplication (GO:0032875)	5.89968098
6	adaptation of signaling pathway (GO:0023058)	4.98311555
7	resolution of meiotic recombination intermediates (GO:0000712)	4.96397894
8	oogenesis (GO:0048477)	4.81297412
9	chromosome organization involved in meiosis (GO:0070192)	4.72702507
10	protein targeting to Golgi (GO:0000042)	4.72389801
11	establishment of protein localization to Golgi (GO:0072600)	4.62422676
12	male meiosis I (GO:0007141)	4.62397479
13	prostate gland growth (GO:0060736)	4.47776022
14	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	4.22737502
15	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.18301770
16	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.06298498
17	trivalent inorganic anion homeostasis (GO:0072506)	4.02403692
18	phosphate ion homeostasis (GO:0055062)	4.02403692
19	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.98500120
20	sister chromatid cohesion (GO:0007062)	3.97914883
21	female gamete generation (GO:0007292)	3.97839759
22	ether lipid metabolic process (GO:0046485)	3.93931670
23	tachykinin receptor signaling pathway (GO:0007217)	3.92963321
24	regulation of DNA damage checkpoint (GO:2000001)	3.83742442
25	nuclear pore organization (GO:0006999)	3.72144014
26	regulation of somitogenesis (GO:0014807)	3.70892547
27	protein localization to Golgi apparatus (GO:0034067)	3.57088388
28	positive regulation of neurotransmitter secretion (GO:0001956)	3.55857239
29	regulation of skeletal muscle contraction (GO:0014819)	3.55602478
30	sulfation (GO:0051923)	3.54891344
31	pore complex assembly (GO:0046931)	3.54234673
32	replicative senescence (GO:0090399)	3.51532255
33	regulation of meiosis I (GO:0060631)	3.47077139
34	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.45454974
35	adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)	3.42556027
36	synaptonemal complex organization (GO:0070193)	3.42082731
37	piRNA metabolic process (GO:0034587)	3.41747437
38	viral mRNA export from host cell nucleus (GO:0046784)	3.39060477
39	positive regulation of vascular permeability (GO:0043117)	3.37571585
40	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	3.37062312
41	regulation of sequestering of triglyceride (GO:0010889)	3.34574446
42	adrenergic receptor signaling pathway (GO:0071875)	3.34344638
43	oocyte maturation (GO:0001556)	3.30087712
44	attachment of spindle microtubules to kinetochore (GO:0008608)	3.29747492
45	histone H3-K36 demethylation (GO:0070544)	3.29619323
46	DNA synthesis involved in DNA repair (GO:0000731)	3.25021169
47	cellular anion homeostasis (GO:0030002)	3.23623858
48	response to epinephrine (GO:0071871)	3.23587793
49	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.20552369
50	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.19301308
51	prenylation (GO:0097354)	3.15272009
52	protein prenylation (GO:0018342)	3.15272009
53	meiosis I (GO:0007127)	3.15182825
54	synaptonemal complex assembly (GO:0007130)	3.13029197
55	potassium ion homeostasis (GO:0055075)	3.12241982
56	metaphase plate congression (GO:0051310)	3.10613680
57	nuclear pore complex assembly (GO:0051292)	3.07885393
58	negative regulation of systemic arterial blood pressure (GO:0003085)	3.03658466
59	calcium ion-dependent exocytosis (GO:0017156)	3.03062715
60	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.02096252
61	phosphatidylcholine biosynthetic process (GO:0006656)	3.00949553
62	negative regulation of smooth muscle contraction (GO:0045986)	2.98687348
63	collecting duct development (GO:0072044)	2.97412043
64	transepithelial transport (GO:0070633)	2.93676818
65	retina layer formation (GO:0010842)	2.92742090
66	histone ubiquitination (GO:0016574)	2.92632170
67	interferon-gamma production (GO:0032609)	2.91258586
68	protein K48-linked deubiquitination (GO:0071108)	2.90338667
69	histone H3-K9 demethylation (GO:0033169)	2.89782242
70	cellular response to epinephrine stimulus (GO:0071872)	2.89159519
71	oligosaccharide catabolic process (GO:0009313)	2.87911211
72	male meiosis (GO:0007140)	2.87064959
73	histone monoubiquitination (GO:0010390)	2.82684839
74	positive regulation of developmental pigmentation (GO:0048087)	2.82650642
75	cAMP biosynthetic process (GO:0006171)	2.82537113
76	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.82238761
77	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.81994342
78	magnesium ion transport (GO:0015693)	2.79127038
79	negative regulation of multicellular organism growth (GO:0040015)	2.77948059
80	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.77809873
81	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.77809873
82	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.77809873
83	positive regulation of urine volume (GO:0035810)	2.77703552
84	aorta morphogenesis (GO:0035909)	2.77624506
85	positive regulation of response to oxidative stress (GO:1902884)	2.75647626
86	positive regulation of cellular response to oxidative stress (GO:1900409)	2.75647626
87	regulation of gonadotropin secretion (GO:0032276)	2.73309236
88	positive regulation of meiosis (GO:0045836)	2.72408628
89	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.71991024
90	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.69283755
91	opsonization (GO:0008228)	2.67259311
92	regulation of establishment of cell polarity (GO:2000114)	2.66268787
93	meiotic cell cycle process (GO:1903046)	2.63704744
94	negative regulation of DNA recombination (GO:0045910)	2.63669960
95	mitotic sister chromatid cohesion (GO:0007064)	2.61424952
96	cerebellar granule cell differentiation (GO:0021707)	2.61393744
97	otic vesicle formation (GO:0030916)	2.61268417
98	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	2.60033169
99	regulation of protein glycosylation (GO:0060049)	2.59637112
100	telomere maintenance via telomerase (GO:0007004)	2.58177217

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	3.52357150
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.25453348
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60167534
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.58508799
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57388619
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.56149708
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.54354231
8	EWS_26573619_Chip-Seq_HEK293_Human	2.48060094
9	GATA1_22025678_ChIP-Seq_K562_Human	2.33868825
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.32083072
11	FUS_26573619_Chip-Seq_HEK293_Human	2.31125813
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16804616
13	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.14327516
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.11143448
15	P300_19829295_ChIP-Seq_ESCs_Human	2.03549697
16	BCAT_22108803_ChIP-Seq_LS180_Human	1.95295435
17	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.87554340
18	CBP_20019798_ChIP-Seq_JUKART_Human	1.87554340
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.87434412
20	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.86504004
21	AR_21572438_ChIP-Seq_LNCaP_Human	1.82455304
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79795325
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78083450
24	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.77337700
25	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.76862200
26	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.74741577
27	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.74683252
28	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.71766586
29	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.67573301
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66862840
31	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.60950826
32	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.60871264
33	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.59142389
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.58408517
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.50844359
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49697702
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49451022
38	TP53_16413492_ChIP-PET_HCT116_Human	1.49056735
39	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.48131691
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45218140
41	EZH2_22144423_ChIP-Seq_EOC_Human	1.44685198
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43273173
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43246931
44	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.42936839
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42705568
46	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.39498846
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38169646
48	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.36392330
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.36280261
50	CDX2_22108803_ChIP-Seq_LS180_Human	1.35967904
51	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.34326380
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.34125266
53	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.33699633
54	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.32990410
55	RUNX_20019798_ChIP-Seq_JUKART_Human	1.32097968
56	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.30931210
57	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.30772594
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30074378
59	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.29406445
60	TCF4_23295773_ChIP-Seq_U87_Human	1.28841791
61	AHR_22903824_ChIP-Seq_MCF-7_Human	1.28276553
62	KDM2B_26808549_Chip-Seq_REH_Human	1.25852608
63	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.23674052
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23274651
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20162154
66	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18384553
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17833052
68	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.16850473
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16572393
70	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.16202018
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15166161
72	STAT3_23295773_ChIP-Seq_U87_Human	1.15143355
73	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.14851992
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.13720909
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.13189013
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12977429
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12977429
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12838608
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.12708346
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11155242
81	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.10975265
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10059842
83	AR_25329375_ChIP-Seq_VCAP_Human	1.09971584
84	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.09292349
85	RXR_22108803_ChIP-Seq_LS180_Human	1.08945009
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.07882233
87	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.07752889
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06678181
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05869894
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05486242
91	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05159143
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04204905
93	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.03682818
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02264014
95	GATA3_27048872_Chip-Seq_THYMUS_Human	1.01786211
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99259918
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98483471
98	TP63_23658742_ChIP-Seq_EP156T_Human	0.98468342
99	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.98446511
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97961409

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	7.25424978
2	MP0002163_abnormal_gland_morphology	5.45604756
3	MP0002009_preneoplasia	4.77720528
4	MP0002160_abnormal_reproductive_system	4.30297618
5	MP0005379_endocrine/exocrine_gland_phen	3.95785947
6	MP0002166_altered_tumor_susceptibility	3.09805278
7	MP0008877_abnormal_DNA_methylation	2.98394215
8	MP0003656_abnormal_erythrocyte_physiolo	2.63469971
9	MP0005389_reproductive_system_phenotype	2.59703913
10	MP0002006_tumorigenesis	2.51090790
11	MP0004381_abnormal_hair_follicle	2.39207504
12	MP0000613_abnormal_salivary_gland	2.19343991
13	MP0000372_irregular_coat_pigmentation	2.16238615
14	MP0005410_abnormal_fertilization	1.88062867
15	MP0002132_abnormal_respiratory_system	1.82111713
16	MP0001542_abnormal_bone_strength	1.81906387
17	MP0005220_abnormal_exocrine_pancreas	1.77398827
18	MP0004084_abnormal_cardiac_muscle	1.71933295
19	MP0005423_abnormal_somatic_nervous	1.66630513
20	MP0009780_abnormal_chondrocyte_physiolo	1.65049217
21	MP0001661_extended_life_span	1.60814430
22	MP0005075_abnormal_melanosome_morpholog	1.57809348
23	MP0001177_atelectasis	1.56053547
24	MP0006292_abnormal_olfactory_placode	1.49610167
25	MP0000427_abnormal_hair_cycle	1.48229513
26	MP0003950_abnormal_plasma_membrane	1.41885904
27	MP0004885_abnormal_endolymph	1.39286198
28	MP0002210_abnormal_sex_determination	1.36813103
29	MP0001929_abnormal_gametogenesis	1.36068851
30	MP0002396_abnormal_hematopoietic_system	1.31439084
31	MP0003693_abnormal_embryo_hatching	1.29978209
32	MP0002735_abnormal_chemical_nociception	1.28185221
33	MP0003221_abnormal_cardiomyocyte_apopto	1.27897486
34	MP0005275_abnormal_skin_tensile	1.26386163
35	MP0000015_abnormal_ear_pigmentation	1.25024032
36	MP0004484_altered_response_of	1.24188742
37	MP0001440_abnormal_grooming_behavior	1.23583852
38	MP0002277_abnormal_respiratory_mucosa	1.18844099
39	MP0000653_abnormal_sex_gland	1.17669785
40	MP0001145_abnormal_male_reproductive	1.17660088
41	MP0004215_abnormal_myocardial_fiber	1.16332997
42	MP0005670_abnormal_white_adipose	1.15312910
43	MP0003959_abnormal_lean_body	1.14048447
44	MP0000569_abnormal_digit_pigmentation	1.12035486
45	MP0006072_abnormal_retinal_apoptosis	1.11090541
46	MP0003698_abnormal_male_reproductive	1.09032497
47	MP0006276_abnormal_autonomic_nervous	1.06822153
48	MP0001879_abnormal_lymphatic_vessel	1.06804161
49	MP0002332_abnormal_exercise_endurance	1.04217563
50	MP0005646_abnormal_pituitary_gland	1.03013482
51	MP0000749_muscle_degeneration	1.01269489
52	MP0008057_abnormal_DNA_replication	1.01160801
53	MP0009697_abnormal_copulation	1.00321225
54	MP0002090_abnormal_vision	0.98250786
55	MP0001119_abnormal_female_reproductive	0.95402904
56	MP0004085_abnormal_heartbeat	0.93857184
57	MP0002254_reproductive_system_inflammat	0.91876180
58	MP0001348_abnormal_lacrimal_gland	0.90800018
59	MP0005464_abnormal_platelet_physiology	0.90458805
60	MP0001666_abnormal_nutrient_absorption	0.89641684
61	MP0006054_spinal_hemorrhage	0.86698828
62	MP0005171_absent_coat_pigmentation	0.85288230
63	MP0008872_abnormal_physiological_respon	0.84137738
64	MP0003763_abnormal_thymus_physiology	0.83445670
65	MP0003724_increased_susceptibility_to	0.82517351
66	MP0000750_abnormal_muscle_regeneration	0.81513507
67	MP0005083_abnormal_biliary_tract	0.78026316
68	MP0002282_abnormal_trachea_morphology	0.77439630
69	MP0003890_abnormal_embryonic-extraembry	0.75234442
70	MP0003718_maternal_effect	0.75082293
71	MP0003646_muscle_fatigue	0.74573037
72	MP0005360_urolithiasis	0.74350198
73	MP0002876_abnormal_thyroid_physiology	0.73864066
74	MP0000462_abnormal_digestive_system	0.71370826
75	MP0009764_decreased_sensitivity_to	0.70812473
76	MP0003121_genomic_imprinting	0.70677541
77	MP0000767_abnormal_smooth_muscle	0.70603712
78	MP0005551_abnormal_eye_electrophysiolog	0.68873640
79	MP0001919_abnormal_reproductive_system	0.67068760
80	MP0003279_aneurysm	0.66730886
81	MP0001984_abnormal_olfaction	0.66038501
82	MP0002108_abnormal_muscle_morphology	0.65370962
83	MP0002127_abnormal_cardiovascular_syste	0.63827220
84	MP0003252_abnormal_bile_duct	0.63291291
85	MP0004883_abnormal_blood_vessel	0.63236274
86	MP0001986_abnormal_taste_sensitivity	0.62209026
87	MP0001800_abnormal_humoral_immune	0.62165621
88	MP0010368_abnormal_lymphatic_system	0.62087945
89	MP0000358_abnormal_cell_content/	0.61678683
90	MP0004036_abnormal_muscle_relaxation	0.61421820
91	MP0001835_abnormal_antigen_presentation	0.60797407
92	MP0002272_abnormal_nervous_system	0.55757895
93	MP0004142_abnormal_muscle_tone	0.55262515
94	MP0005330_cardiomyopathy	0.54136198
95	MP0003448_altered_tumor_morphology	0.53951296
96	MP0002138_abnormal_hepatobiliary_system	0.53072744
97	MP0004510_myositis	0.52190046
98	MP0008873_increased_physiological_sensi	0.50992221
99	MP0003936_abnormal_reproductive_system	0.50671282
100	MP0003868_abnormal_feces_composition	0.49775398

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Diastasis recti (HP:0001540)	5.49661623
2	Carpal bone hypoplasia (HP:0001498)	4.94403985
3	Recurrent bronchitis (HP:0002837)	4.49114226
4	Aplasia of the musculature (HP:0100854)	4.48599342
5	Spontaneous abortion (HP:0005268)	4.48120190
6	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	4.37760647
7	J-shaped sella turcica (HP:0002680)	4.18471141
8	Chronic sinusitis (HP:0011109)	4.14646513
9	Visual hallucinations (HP:0002367)	4.11220609
10	Symphalangism affecting the phalanges of the hand (HP:0009773)	4.09029461
11	Myelomeningocele (HP:0002475)	4.08547945
12	Abnormality of the lumbar spine (HP:0100712)	3.99658628
13	Papilledema (HP:0001085)	3.67385586
14	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	3.38227211
15	Oligodactyly (hands) (HP:0001180)	3.33346531
16	Amniotic constriction ring (HP:0009775)	3.33313356
17	Abnormality of placental membranes (HP:0011409)	3.33313356
18	Broad ribs (HP:0000885)	3.28299753
19	Slow saccadic eye movements (HP:0000514)	3.19593173
20	Azoospermia (HP:0000027)	3.15834778
21	Thoracolumbar scoliosis (HP:0002944)	3.12974380
22	T lymphocytopenia (HP:0005403)	3.12898339
23	Vertebral arch anomaly (HP:0008438)	3.10892478
24	Hypoplastic pelvis (HP:0008839)	3.09677309
25	Abnormality of the phalanges of the 5th finger (HP:0004213)	3.03275121
26	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.02402194
27	Broad alveolar ridges (HP:0000187)	2.97741025
28	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.94916936
29	B lymphocytopenia (HP:0010976)	2.73969321
30	Abolished electroretinogram (ERG) (HP:0000550)	2.73853358
31	Hypoplastic scapulae (HP:0000882)	2.73725137
32	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.73725137
33	Recurrent pneumonia (HP:0006532)	2.73337249
34	Albinism (HP:0001022)	2.70372700
35	Abnormal spermatogenesis (HP:0008669)	2.69001560
36	Abnormality of T cell number (HP:0011839)	2.68525279
37	Abnormality of the epiphyses of the hand (HP:0005924)	2.65646957
38	Anomalous pulmonary venous return (HP:0010772)	2.61925082
39	Hypoplastic nipples (HP:0002557)	2.61810367
40	Protuberant abdomen (HP:0001538)	2.60003791
41	Abnormality of the odontoid process (HP:0003310)	2.57467272
42	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	2.57347180
43	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.56654055
44	Abnormality of glycolipid metabolism (HP:0010969)	2.56654055
45	Abnormality of liposaccharide metabolism (HP:0010968)	2.56654055
46	Bronchitis (HP:0012387)	2.55802883
47	Pancreatic cysts (HP:0001737)	2.54473044
48	Abnormal pancreas size (HP:0012094)	2.50116680
49	Volvulus (HP:0002580)	2.47113269
50	Microcytic anemia (HP:0001935)	2.46716152
51	Abnormality of B cell number (HP:0010975)	2.37760679
52	Neonatal respiratory distress (HP:0002643)	2.31986324
53	Abnormality of the pulmonary veins (HP:0011718)	2.29710519
54	Popliteal pterygium (HP:0009756)	2.29126571
55	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.24100378
56	Long clavicles (HP:0000890)	2.20553227
57	Abnormality of the sella turcica (HP:0002679)	2.19135063
58	Duplicated collecting system (HP:0000081)	2.17816872
59	Cavernous hemangioma (HP:0001048)	2.16777649
60	Thyroiditis (HP:0100646)	2.15376179
61	Focal motor seizures (HP:0011153)	2.15354900
62	Aortic regurgitation (HP:0001659)	2.14622932
63	Acute hepatic failure (HP:0006554)	2.08158442
64	Abnormality of the renal collecting system (HP:0004742)	2.07202321
65	Aplasia/Hypoplasia of the clavicles (HP:0006710)	2.05932145
66	Meningocele (HP:0002435)	2.05127120
67	Deformed sella turcica (HP:0002681)	2.04322262
68	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.03267740
69	Short clavicles (HP:0000894)	2.01983084
70	Hypochromic microcytic anemia (HP:0004840)	2.01551900
71	Split foot (HP:0001839)	1.99209135
72	Ankyloglossia (HP:0010296)	1.95933876
73	Flat acetabular roof (HP:0003180)	1.95703264
74	Agnosia (HP:0010524)	1.95598922
75	Choroideremia (HP:0001139)	1.94781483
76	Capillary hemangiomas (HP:0005306)	1.94382208
77	Supernumerary nipples (HP:0002558)	1.90297362
78	Pulmonary artery stenosis (HP:0004415)	1.87986803
79	Oligodactyly (HP:0012165)	1.85573754
80	Hypoplasia of the thymus (HP:0000778)	1.85246108
81	Oral leukoplakia (HP:0002745)	1.83547282
82	Thoracic kyphosis (HP:0002942)	1.82986118
83	Fatigue (HP:0012378)	1.82453516
84	Abnormality of chloride homeostasis (HP:0011422)	1.82233834
85	Tongue fasciculations (HP:0001308)	1.79594914
86	Preauricular pit (HP:0004467)	1.77964895
87	Periauricular skin pits (HP:0100277)	1.77964895
88	Abnormality of the right ventricle (HP:0001707)	1.74272155
89	Hypoplasia of the odontoid process (HP:0003311)	1.74078925
90	Widely spaced teeth (HP:0000687)	1.73218079
91	Short ribs (HP:0000773)	1.73009360
92	Abnormality of the alveolar ridges (HP:0006477)	1.71133287
93	Ureteral duplication (HP:0000073)	1.67946489
94	Broad nasal tip (HP:0000455)	1.67854112
95	Exocrine pancreatic insufficiency (HP:0001738)	1.67514277
96	Slender build (HP:0001533)	1.66574459
97	Prominent occiput (HP:0000269)	1.65488536
98	Concave nail (HP:0001598)	1.65204367
99	Akinesia (HP:0002304)	1.64709779
100	Recurrent lower respiratory tract infections (HP:0002783)	1.64320729

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK7	5.13069059
2	TGFBR2	4.94449316
3	BLK	4.36088695
4	EIF2AK3	3.42595369
5	GRK5	3.21239201
6	MOS	2.98763735
7	LMTK2	2.86869590
8	ACVR1B	2.83897567
9	PAK3	2.65924836
10	FRK	2.52013179
11	STK10	2.30380129
12	PLK2	1.98066566
13	MAP4K2	1.97888081
14	FER	1.87067253
15	MST4	1.82371447
16	NEK9	1.80348877
17	PRKCI	1.65930923
18	IRAK2	1.64096517
19	EIF2AK2	1.49161543
20	MAP3K12	1.43729326
21	TEC	1.34550552
22	WNK1	1.30638486
23	MAP3K6	1.26040451
24	IRAK4	1.21616075
25	MAP2K4	1.21418016
26	MAP3K2	1.19426662
27	STK24	1.18706403
28	STK39	1.16652261
29	ZAK	1.15916451
30	IKBKE	1.15719255
31	ERBB3	1.10583652
32	ADRBK1	1.09397676
33	SYK	1.07079587
34	PNCK	1.05045528
35	BMPR2	1.00698934
36	OXSR1	0.97594751
37	TAF1	0.95171367
38	STK3	0.94653501
39	MAP2K1	0.92089693
40	TXK	0.90621484
41	PTK2	0.88793906
42	PLK4	0.88019499
43	MAP3K4	0.86985404
44	MATK	0.86464812
45	IRAK1	0.83029916
46	MAP3K5	0.81963364
47	AKT3	0.80439015
48	CAMK4	0.77645945
49	MKNK2	0.77423800
50	MYLK	0.75463687
51	PINK1	0.74857169
52	CAMKK2	0.74823382
53	FLT3	0.72068499
54	MAP3K11	0.71572863
55	BRSK2	0.68902357
56	PRKD1	0.66852628
57	FGFR1	0.66775664
58	TNIK	0.65878103
59	MELK	0.62603130
60	MAP2K3	0.61239266
61	GRK6	0.60020396
62	PTK2B	0.56751975
63	MAP2K6	0.53227038
64	PLK3	0.50891364
65	CAMK1G	0.48051027
66	PAK1	0.47680422
67	GRK1	0.45143631
68	JAK2	0.44343777
69	PKN2	0.44317430
70	MKNK1	0.43546929
71	DMPK	0.43519351
72	PRKCQ	0.43077549
73	PRKG1	0.42816309
74	IGF1R	0.41891882
75	MAP2K7	0.41607560
76	INSRR	0.41515368
77	NUAK1	0.40569546
78	SGK1	0.40125917
79	WEE1	0.38804760
80	GSK3A	0.38112562
81	PRKG2	0.37274412
82	OBSCN	0.36604594
83	STK11	0.36086909
84	KIT	0.34027674
85	DYRK1A	0.34017545
86	PIM1	0.33529036
87	NEK6	0.33382666
88	NLK	0.33359223
89	WNK4	0.33189256
90	BMPR1B	0.32797948
91	MAPKAPK2	0.32764916
92	STK4	0.32596882
93	LYN	0.32057668
94	MAP4K1	0.31448063
95	INSR	0.31166090
96	ITK	0.30803992
97	AKT2	0.30085955
98	PDK1	0.29948193
99	TRPM7	0.29092190
100	CHEK2	0.28881047

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.56047121
2	Caffeine metabolism_Homo sapiens_hsa00232	3.15149187
3	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.77826749
4	Ether lipid metabolism_Homo sapiens_hsa00565	2.52606879
5	Platelet activation_Homo sapiens_hsa04611	2.29572824
6	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.26480587
7	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.17026737
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.08922458
9	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.88858431
10	ABC transporters_Homo sapiens_hsa02010	1.76150902
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68780769
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.67002160
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55200727
14	Basal transcription factors_Homo sapiens_hsa03022	1.54354970
15	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.42827892
16	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.33271202
17	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.31460953
18	Oocyte meiosis_Homo sapiens_hsa04114	1.26124348
19	Renin secretion_Homo sapiens_hsa04924	1.24128189
20	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.23850706
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22051552
22	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.19922848
23	cAMP signaling pathway_Homo sapiens_hsa04024	1.17164471
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14930086
25	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.11468336
26	Gastric acid secretion_Homo sapiens_hsa04971	1.11397958
27	RNA transport_Homo sapiens_hsa03013	1.10684194
28	Pancreatic secretion_Homo sapiens_hsa04972	1.09927462
29	Cholinergic synapse_Homo sapiens_hsa04725	1.09100577
30	Salivary secretion_Homo sapiens_hsa04970	1.06685848
31	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.05691200
32	Bile secretion_Homo sapiens_hsa04976	1.03563386
33	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.01144786
34	Phototransduction_Homo sapiens_hsa04744	1.00047211
35	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.98990972
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97641829
37	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.92956067
38	Taste transduction_Homo sapiens_hsa04742	0.92778422
39	Osteoclast differentiation_Homo sapiens_hsa04380	0.92200867
40	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.89995602
41	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.89437362
42	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89378456
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88955784
44	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.86002780
45	Olfactory transduction_Homo sapiens_hsa04740	0.85720525
46	Protein export_Homo sapiens_hsa03060	0.82324119
47	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.79945196
48	Circadian entrainment_Homo sapiens_hsa04713	0.79937835
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79186888
50	Regulation of autophagy_Homo sapiens_hsa04140	0.79156766
51	RNA degradation_Homo sapiens_hsa03018	0.77347302
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77008015
53	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.74664432
54	Small cell lung cancer_Homo sapiens_hsa05222	0.73504005
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.73289438
56	Melanoma_Homo sapiens_hsa05218	0.73107532
57	Mismatch repair_Homo sapiens_hsa03430	0.72372183
58	p53 signaling pathway_Homo sapiens_hsa04115	0.72339297
59	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.70302284
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.69177478
61	Viral carcinogenesis_Homo sapiens_hsa05203	0.69155100
62	Retinol metabolism_Homo sapiens_hsa00830	0.68296599
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67955494
64	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.65033666
65	Long-term depression_Homo sapiens_hsa04730	0.63498975
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.63458349
67	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.62017217
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.60300588
69	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.60180397
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59497167
71	Glutamatergic synapse_Homo sapiens_hsa04724	0.58301308
72	Type II diabetes mellitus_Homo sapiens_hsa04930	0.57498391
73	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.57209333
74	ECM-receptor interaction_Homo sapiens_hsa04512	0.57032434
75	Cell cycle_Homo sapiens_hsa04110	0.56611628
76	Hepatitis C_Homo sapiens_hsa05160	0.56017275
77	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54601058
78	MAPK signaling pathway_Homo sapiens_hsa04010	0.53291598
79	Leishmaniasis_Homo sapiens_hsa05140	0.52992953
80	Choline metabolism in cancer_Homo sapiens_hsa05231	0.52983591
81	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51656337
82	Propanoate metabolism_Homo sapiens_hsa00640	0.51532905
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.51363298
84	Mineral absorption_Homo sapiens_hsa04978	0.49734719
85	Morphine addiction_Homo sapiens_hsa05032	0.48933260
86	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48576871
87	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.48268831
88	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.47414494
89	GABAergic synapse_Homo sapiens_hsa04727	0.45706628
90	mTOR signaling pathway_Homo sapiens_hsa04150	0.45377473
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.44128183
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43366308
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43223061
94	Sulfur relay system_Homo sapiens_hsa04122	0.40642076
95	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.40310976
96	Colorectal cancer_Homo sapiens_hsa05210	0.40124903
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39180298
98	Gap junction_Homo sapiens_hsa04540	0.38999054
99	GnRH signaling pathway_Homo sapiens_hsa04912	0.38119097
100	Renal cell carcinoma_Homo sapiens_hsa05211	0.37616090

RHOQP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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