RHOT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.74335338
2transcription from mitochondrial promoter (GO:0006390)6.13103945
3proline metabolic process (GO:0006560)5.93054360
4embryonic process involved in female pregnancy (GO:0060136)5.65906206
5replication fork processing (GO:0031297)5.40264065
6regulation of rhodopsin mediated signaling pathway (GO:0022400)4.97364409
7neural tube formation (GO:0001841)4.94740931
8oxidative demethylation (GO:0070989)4.93621711
9rhodopsin mediated signaling pathway (GO:0016056)4.92435600
10limb bud formation (GO:0060174)4.91520476
11positive regulation of dendritic spine morphogenesis (GO:0061003)4.48319210
12negative regulation of JAK-STAT cascade (GO:0046426)4.32063936
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.30862414
14nerve growth factor signaling pathway (GO:0038180)4.18764940
15regulation of integrin activation (GO:0033623)4.15240355
16DNA deamination (GO:0045006)4.11478412
17mitotic G1 DNA damage checkpoint (GO:0031571)4.10503132
18pyrimidine nucleobase catabolic process (GO:0006208)4.05554817
19positive regulation of protein homooligomerization (GO:0032464)4.03830536
20negative regulation of fatty acid biosynthetic process (GO:0045717)4.02986573
21embryonic placenta development (GO:0001892)4.02263519
22establishment of apical/basal cell polarity (GO:0035089)4.00135304
23mitochondrial DNA metabolic process (GO:0032042)3.97284939
24cellular response to ATP (GO:0071318)3.92852182
25regulation of protein homooligomerization (GO:0032462)3.92273414
26negative regulation of cytosolic calcium ion concentration (GO:0051481)3.88295105
27ether lipid metabolic process (GO:0046485)3.84728756
28regulation of sister chromatid cohesion (GO:0007063)3.82426896
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.78674154
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.78674154
31positive regulation of mitotic sister chromatid separation (GO:1901970)3.78674154
32retinal cone cell development (GO:0046549)3.78485615
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77009764
34early endosome to late endosome transport (GO:0045022)3.76544036
35secondary heart field specification (GO:0003139)3.76195555
36heart field specification (GO:0003128)3.76195555
37regulation of RNA export from nucleus (GO:0046831)3.70547676
38regulation of synaptic vesicle exocytosis (GO:2000300)3.70359434
39poly(A)+ mRNA export from nucleus (GO:0016973)3.70089958
40G1 DNA damage checkpoint (GO:0044783)3.69739299
41mitotic G1/S transition checkpoint (GO:0044819)3.65201226
42cardiac right ventricle morphogenesis (GO:0003215)3.63790077
43phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.61256018
44regulation of cAMP-dependent protein kinase activity (GO:2000479)3.61188359
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.59874953
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.59874953
47synaptic vesicle maturation (GO:0016188)3.58964646
48negative regulation of dendrite development (GO:2000171)3.55286045
49embryonic camera-type eye development (GO:0031076)3.54934746
50establishment or maintenance of monopolar cell polarity (GO:0061339)3.54661455
51establishment of monopolar cell polarity (GO:0061162)3.54661455
52negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.51273470
53labyrinthine layer development (GO:0060711)3.50298480
54glutamine family amino acid biosynthetic process (GO:0009084)3.49822890
55protein targeting to lysosome (GO:0006622)3.47606394
56establishment of protein localization to vacuole (GO:0072666)3.47606394
57protein targeting to vacuole (GO:0006623)3.47606394
58synaptic vesicle endocytosis (GO:0048488)3.45186708
59negative regulation of Ras GTPase activity (GO:0034261)3.45024254
60negative regulation of cell cycle arrest (GO:0071157)3.44423646
61behavioral response to ethanol (GO:0048149)3.41470000
62nucleobase catabolic process (GO:0046113)3.39518036
63detection of light stimulus involved in sensory perception (GO:0050962)3.37675371
64detection of light stimulus involved in visual perception (GO:0050908)3.37675371
65retinal rod cell development (GO:0046548)3.37473709
66dopamine biosynthetic process (GO:0042416)3.36435581
67regulation of protein polyubiquitination (GO:1902914)3.36143780
68regulation of synaptic vesicle transport (GO:1902803)3.31840027
69regulation of relaxation of muscle (GO:1901077)3.31390413
70protein localization to endosome (GO:0036010)3.30783367
71clathrin coat assembly (GO:0048268)3.30378594
72DNA strand renaturation (GO:0000733)3.29472547
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28804968
74maturation of 5.8S rRNA (GO:0000460)3.28603062
75photoreceptor cell development (GO:0042461)3.27990524
76neuron cell-cell adhesion (GO:0007158)3.27355720
77response to pheromone (GO:0019236)3.23663875
78single strand break repair (GO:0000012)3.20876646
79membrane tubulation (GO:0097320)3.19856014
80regulation of translational fidelity (GO:0006450)3.18989374
81negative regulation of protein oligomerization (GO:0032460)3.16097944
82regulation of early endosome to late endosome transport (GO:2000641)3.15370868
83synaptic vesicle exocytosis (GO:0016079)3.15296143
84negative regulation of neurotransmitter transport (GO:0051589)3.14980136
85ribonucleoprotein complex disassembly (GO:0032988)3.13601608
86regulation of dendritic spine morphogenesis (GO:0061001)3.13543006
87non-recombinational repair (GO:0000726)3.13495447
88double-strand break repair via nonhomologous end joining (GO:0006303)3.13495447
89inositol phosphate catabolic process (GO:0071545)3.11446995
90eye photoreceptor cell development (GO:0042462)3.11162760
91positive regulation of developmental pigmentation (GO:0048087)3.10834060
92presynaptic membrane organization (GO:0097090)3.09426753
93mitochondrial fusion (GO:0008053)3.09407245
94mitochondrial RNA metabolic process (GO:0000959)3.09368479
95DNA integration (GO:0015074)3.06443571
96regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.02761267
97presynaptic membrane assembly (GO:0097105)3.01723593
98photoreceptor cell maintenance (GO:0045494)3.01651029
99mRNA cleavage (GO:0006379)3.00318676
100cellular response to light stimulus (GO:0071482)3.00279344
101establishment of protein localization to mitochondrial membrane (GO:0090151)3.00024008
102positive regulation of chromosome segregation (GO:0051984)2.98987211
103negative regulation of dendrite morphogenesis (GO:0050774)2.97170292
104pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.97051853
105regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.96671589
106positive regulation of circadian rhythm (GO:0042753)2.95822560
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95765832
108regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.95209467
109convergent extension (GO:0060026)2.88205446
110protein-chromophore linkage (GO:0018298)2.86995960
111regulation of clathrin-mediated endocytosis (GO:2000369)2.86310860
112ionotropic glutamate receptor signaling pathway (GO:0035235)2.84962786
113regulation of nucleobase-containing compound transport (GO:0032239)2.84722006
114cellular response to zinc ion (GO:0071294)2.82983222
115negative regulation of DNA recombination (GO:0045910)2.82568986
116GMP metabolic process (GO:0046037)2.82376887
117activation of Rac GTPase activity (GO:0032863)2.79942177
118nodal signaling pathway (GO:0038092)2.78262869
119neuron-neuron synaptic transmission (GO:0007270)2.77414167
120base-excision repair, AP site formation (GO:0006285)2.76679458
121glutamate receptor signaling pathway (GO:0007215)2.76352872
122pyrimidine nucleotide catabolic process (GO:0006244)2.73943438
123neuromuscular process controlling posture (GO:0050884)2.73165375
124relaxation of cardiac muscle (GO:0055119)2.72823229
125regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70473865
126glial cell migration (GO:0008347)2.70377947
127protein localization to synapse (GO:0035418)2.70061349
128regulation of cell communication by electrical coupling (GO:0010649)2.69838409
129dopamine transport (GO:0015872)2.67796499
130regulation of protein glycosylation (GO:0060049)2.67764683
131mitochondrion distribution (GO:0048311)2.67520893
132centrosome localization (GO:0051642)2.67258111
133glutamate secretion (GO:0014047)2.66090395
134inositol phosphate dephosphorylation (GO:0046855)2.66042162
135phosphorylated carbohydrate dephosphorylation (GO:0046838)2.66042162
136cell migration in hindbrain (GO:0021535)2.65857749
137base-excision repair (GO:0006284)2.65377231
138regulation of DNA damage checkpoint (GO:2000001)2.63841403
139acrosome assembly (GO:0001675)2.63839422
140relaxation of muscle (GO:0090075)2.63613897
141asymmetric protein localization (GO:0008105)2.62594635
142negative regulation of heart rate (GO:0010459)2.62390145
143negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62092337
144relaxation of smooth muscle (GO:0044557)2.61509757
145layer formation in cerebral cortex (GO:0021819)2.60471535
146dosage compensation (GO:0007549)2.59477764
147viral mRNA export from host cell nucleus (GO:0046784)2.58962567
148axonal fasciculation (GO:0007413)2.58363061
149carnitine shuttle (GO:0006853)2.56343760
150visual perception (GO:0007601)2.56048513
151regulation of mitochondrial depolarization (GO:0051900)2.56031783
152regulation of pigment cell differentiation (GO:0050932)2.55724968
153inositol metabolic process (GO:0006020)2.55344643
154spinal cord development (GO:0021510)2.55294873
155prenylation (GO:0097354)2.54612278
156protein prenylation (GO:0018342)2.54612278
157synaptic transmission, glutamatergic (GO:0035249)2.53410882
158regulation of meiosis I (GO:0060631)2.51773280
159epithelial cell differentiation involved in kidney development (GO:0035850)2.51572614
160regulation of penile erection (GO:0060405)2.49495202
161neurotransmitter-gated ion channel clustering (GO:0072578)2.48055875
162cerebellar Purkinje cell differentiation (GO:0021702)2.48001970
163gene silencing by RNA (GO:0031047)2.46943495
164gamma-aminobutyric acid signaling pathway (GO:0007214)2.45657900
165exploration behavior (GO:0035640)2.45537902
166seminiferous tubule development (GO:0072520)2.45137858
167glial cell proliferation (GO:0014009)2.43949279
168ubiquinone metabolic process (GO:0006743)2.43931813
169Golgi to endosome transport (GO:0006895)2.43115537
170regulation of collateral sprouting (GO:0048670)2.42374340
171piRNA metabolic process (GO:0034587)2.41243153
172response to cocaine (GO:0042220)2.40990375
173regulation of glutamate receptor signaling pathway (GO:1900449)2.40296709
174proline transport (GO:0015824)2.39940080
175negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.39222616
176neurofilament cytoskeleton organization (GO:0060052)2.38780272
177microtubule anchoring (GO:0034453)2.36313101
178establishment of synaptic vesicle localization (GO:0097480)2.35808954
179synaptic vesicle transport (GO:0048489)2.35808954
180central nervous system projection neuron axonogenesis (GO:0021952)2.35681318
181protein targeting to Golgi (GO:0000042)2.35194561
182neuronal action potential propagation (GO:0019227)2.34378897
183pyrimidine dimer repair (GO:0006290)2.34000566
184regulation of dendritic spine development (GO:0060998)2.33710699
185phosphorelay signal transduction system (GO:0000160)2.33166366
186positive regulation of vasculogenesis (GO:2001214)2.31537712
187dendrite morphogenesis (GO:0048813)2.30683761
188neurotransmitter secretion (GO:0007269)2.30531802
189* organelle transport along microtubule (GO:0072384)2.30021811
190establishment of vesicle localization (GO:0051650)2.29419256
191mitotic sister chromatid cohesion (GO:0007064)2.29399013
192regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.27334920
193regulation of neurotransmitter secretion (GO:0046928)2.26667874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.53209136
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.53060239
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.37029680
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.34725829
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.34381984
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.24740694
7IGF1R_20145208_ChIP-Seq_DFB_Human3.18889850
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.17658901
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.94749175
10SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.93980169
11TAF15_26573619_Chip-Seq_HEK293_Human2.91836226
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.87562668
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.79135520
14EZH2_22144423_ChIP-Seq_EOC_Human2.77681019
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75144539
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.72059280
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.68741341
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.63383298
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.55474899
20NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.46675874
21FUS_26573619_Chip-Seq_HEK293_Human2.44823094
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.33722993
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.33516482
24ZNF274_21170338_ChIP-Seq_K562_Hela2.25474684
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.21468665
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15858387
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15858387
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15858387
29P300_19829295_ChIP-Seq_ESCs_Human2.05338822
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.04957686
31NANOG_21062744_ChIP-ChIP_HESCs_Human2.03465232
32* POU5F1_16518401_ChIP-PET_MESCs_Mouse2.02161815
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00735837
34NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.00025307
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99797855
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99289621
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99154141
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98612963
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94267062
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91735619
41ZNF263_19887448_ChIP-Seq_K562_Human1.91010224
42EWS_26573619_Chip-Seq_HEK293_Human1.90363515
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.89885115
44SMAD4_21799915_ChIP-Seq_A2780_Human1.88428798
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.87595787
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86715238
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84803671
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.82532425
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77968656
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76900732
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74063623
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.73396517
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.73274966
54ER_23166858_ChIP-Seq_MCF-7_Human1.71942981
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.67370276
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67280103
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66612380
58STAT3_23295773_ChIP-Seq_U87_Human1.66570140
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.64337360
60SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.61771164
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61673956
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60266099
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60049733
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.59716318
65NANOG_18692474_ChIP-Seq_MESCs_Mouse1.59060277
66TCF4_23295773_ChIP-Seq_U87_Human1.53500947
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53215703
68CBP_20019798_ChIP-Seq_JUKART_Human1.52906308
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52906308
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51573387
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.50073088
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48738880
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48738880
74SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46526507
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46232985
76VDR_22108803_ChIP-Seq_LS180_Human1.45850866
77RNF2_27304074_Chip-Seq_NSC_Mouse1.44212195
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.42841186
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.42528482
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42390808
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40910889
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39575884
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38251514
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.38029003
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37450734
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.37127690
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35866061
88AR_25329375_ChIP-Seq_VCAP_Human1.35804922
89* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34737873
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.33983241
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32278154
92* FLI1_21867929_ChIP-Seq_TH2_Mouse1.32185197
93SOX2_18692474_ChIP-Seq_MESCs_Mouse1.32089536
94RXRA_24833708_ChIP-Seq_LIVER_Mouse1.31958398
95POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.30922140
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.30872234
97TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.30644345
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30614721
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29938846
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.29231753
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29008781
102RUNX2_22187159_ChIP-Seq_PCA_Human1.28629730
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28270696
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27212313
105P53_22387025_ChIP-Seq_ESCs_Mouse1.26753437
106TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26573939
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25493418
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.25371322
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25048713
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24203806
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.23287004
112* NANOG_16518401_ChIP-PET_MESCs_Mouse1.22233397
113* TET1_21490601_ChIP-Seq_MESCs_Mouse1.22126449
114AR_21572438_ChIP-Seq_LNCaP_Human1.21895575
115* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21343331
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21294704
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21010038
118BCAT_22108803_ChIP-Seq_LS180_Human1.20343427
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.19885109
120YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19536485
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18688062
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18688062
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18544630
124VDR_21846776_ChIP-Seq_THP-1_Human1.18254940
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.18244955
126KDM2B_26808549_Chip-Seq_DND41_Human1.17865608
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17594850
128SPI1_26923725_Chip-Seq_HPCs_Mouse1.17490351
129SOX2_21211035_ChIP-Seq_LN229_Gbm1.15979442
130* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15318558
131KDM2B_26808549_Chip-Seq_K562_Human1.14824849
132P300_18555785_Chip-Seq_ESCs_Mouse1.13993798
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13758318
134LXR_22292898_ChIP-Seq_THP-1_Human1.13701883
135REST_21632747_ChIP-Seq_MESCs_Mouse1.13561281
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13208825
137* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12898032
138ETS1_21867929_ChIP-Seq_TH2_Mouse1.12485858
139NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11806196
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10710274
141* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09655934
142CTCF_27219007_Chip-Seq_Bcells_Human1.09004965
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08939211
144RARB_27405468_Chip-Seq_BRAIN_Mouse1.08705143
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07956303
146KAP1_27257070_Chip-Seq_ESCs_Mouse1.07800141
147NFE2_27457419_Chip-Seq_LIVER_Mouse1.07787666
148TET1_21451524_ChIP-Seq_MESCs_Mouse1.07762216
149WT1_19549856_ChIP-ChIP_CCG9911_Human1.06997246
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06799489
151STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06627244
152JUN_21703547_ChIP-Seq_K562_Human1.06613779
153KDM2B_26808549_Chip-Seq_JURKAT_Human1.06307287
154HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06283324
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05606079
156* CRX_20693478_ChIP-Seq_RETINA_Mouse1.04619111
157TCF4_22108803_ChIP-Seq_LS180_Human1.03957849
158P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03034753
159TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02912984
160SOX2_18555785_Chip-Seq_ESCs_Mouse1.02134760
161* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02016495
162TBL1_22424771_ChIP-Seq_293T_Human1.01961221
163TP53_23651856_ChIP-Seq_MEFs_Mouse1.01926804
164OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01723377
165SOX9_26525672_Chip-Seq_HEART_Mouse1.00996979
166MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00809676
167KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00641181
168SMAD4_21741376_ChIP-Seq_EPCs_Human1.00592323
169STAT3_18555785_Chip-Seq_ESCs_Mouse1.00481574
170* REST_18959480_ChIP-ChIP_MESCs_Mouse1.00218894
171ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99642248
172OCT4_18555785_Chip-Seq_ESCs_Mouse0.99560701
173CBX2_27304074_Chip-Seq_ESCs_Mouse0.98753830
174CREB1_26743006_Chip-Seq_LNCaP_Human0.98604069
175CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98035592
176* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97305100
177CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96161032
178KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95828427
179* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95284222
180WDR5_24793694_ChIP-Seq_LNCAP_Human0.95201632
181THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94696801
182PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94565361
183* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93712519
184RARB_24833708_ChIP-Seq_LIVER_Mouse0.93691333
185MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92873824
186STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90973392
187FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89522771
188FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89463202
189RARA_24833708_ChIP-Seq_LIVER_Mouse0.88293645
190EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86753279
191* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85904329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.59552012
2MP0006072_abnormal_retinal_apoptosis4.62207992
3MP0005551_abnormal_eye_electrophysiolog4.42863862
4MP0008057_abnormal_DNA_replication4.08003485
5MP0003880_abnormal_central_pattern4.01981201
6MP0004233_abnormal_muscle_weight3.79745297
7MP0005253_abnormal_eye_physiology3.43032352
8MP0003011_delayed_dark_adaptation3.02352998
9MP0003787_abnormal_imprinting2.91783771
10MP0005171_absent_coat_pigmentation2.54248329
11MP0010030_abnormal_orbit_morphology2.44408127
12MP0003890_abnormal_embryonic-extraembry2.43350675
13MP0002009_preneoplasia2.41448100
14MP0001486_abnormal_startle_reflex2.35849764
15MP0002653_abnormal_ependyma_morphology2.33098165
16MP0003950_abnormal_plasma_membrane2.31310538
17MP0005423_abnormal_somatic_nervous2.24824315
18MP0008877_abnormal_DNA_methylation2.23308526
19MP0006276_abnormal_autonomic_nervous2.20679470
20MP0003122_maternal_imprinting2.20644849
21MP0001529_abnormal_vocalization2.08562099
22MP0005195_abnormal_posterior_eye2.05973389
23MP0001324_abnormal_eye_pigmentation2.02305530
24MP0003121_genomic_imprinting2.00656084
25MP0009278_abnormal_bone_marrow1.98235292
26MP0001984_abnormal_olfaction1.87374441
27MP0004484_altered_response_of1.82222984
28MP0002272_abnormal_nervous_system1.79660749
29MP0005391_vision/eye_phenotype1.79575187
30MP0010094_abnormal_chromosome_stability1.77918148
31MP0004147_increased_porphyrin_level1.76564726
32MP0001188_hyperpigmentation1.74414418
33MP0000751_myopathy1.68574873
34MP0003718_maternal_effect1.67437903
35MP0002638_abnormal_pupillary_reflex1.65284066
36MP0002269_muscular_atrophy1.62550063
37MP0009745_abnormal_behavioral_response1.61298753
38MP0005330_cardiomyopathy1.55858840
39MP0001177_atelectasis1.54175968
40MP0010234_abnormal_vibrissa_follicle1.49093647
41MP0002229_neurodegeneration1.49069462
42MP0004811_abnormal_neuron_physiology1.48912798
43MP0002332_abnormal_exercise_endurance1.48202515
44MP0003137_abnormal_impulse_conducting1.47232626
45MP0008058_abnormal_DNA_repair1.41067658
46MP0004145_abnormal_muscle_electrophysio1.41062277
47MP0000015_abnormal_ear_pigmentation1.40644662
48MP0002064_seizures1.40482254
49MP0004859_abnormal_synaptic_plasticity1.39407631
50MP0003786_premature_aging1.29528755
51MP0008995_early_reproductive_senescence1.29499937
52MP0002735_abnormal_chemical_nociception1.29494190
53MP0005075_abnormal_melanosome_morpholog1.23674821
54MP0009703_decreased_birth_body1.23562174
55MP0003656_abnormal_erythrocyte_physiolo1.22253764
56MP0002084_abnormal_developmental_patter1.21616493
57MP0001697_abnormal_embryo_size1.21560681
58MP0001501_abnormal_sleep_pattern1.19410626
59MP0002067_abnormal_sensory_capabilities1.17862489
60MP0003119_abnormal_digestive_system1.17070047
61MP0000013_abnormal_adipose_tissue1.15803451
62MP0004133_heterotaxia1.15101227
63MP0000579_abnormal_nail_morphology1.15097840
64MP0001929_abnormal_gametogenesis1.14204070
65MP0005084_abnormal_gallbladder_morpholo1.14193252
66MP0001502_abnormal_circadian_rhythm1.13613623
67MP0010678_abnormal_skin_adnexa1.11344634
68MP0009697_abnormal_copulation1.11232038
69MP0005670_abnormal_white_adipose1.10399443
70MP0010307_abnormal_tumor_latency1.10223775
71MP0002734_abnormal_mechanical_nocicepti1.09247020
72MP0003183_abnormal_peptide_metabolism1.08781731
73MP0002085_abnormal_embryonic_tissue1.08420783
74MP0000427_abnormal_hair_cycle1.08301937
75MP0001293_anophthalmia1.08036929
76MP0002752_abnormal_somatic_nervous1.07725093
77MP0002063_abnormal_learning/memory/cond1.07627420
78MP0005187_abnormal_penis_morphology1.07077934
79MP0005365_abnormal_bile_salt1.06201266
80MP0003646_muscle_fatigue1.05939645
81MP0008775_abnormal_heart_ventricle1.05812473
82MP0002733_abnormal_thermal_nociception1.05764344
83MP0002909_abnormal_adrenal_gland1.05722808
84MP0004885_abnormal_endolymph1.04896882
85MP0001968_abnormal_touch/_nociception1.04411666
86MP0003699_abnormal_female_reproductive1.04234479
87MP0002086_abnormal_extraembryonic_tissu1.02969317
88MP0003221_abnormal_cardiomyocyte_apopto1.02904714
89MP0009046_muscle_twitch1.02619149
90MP0003567_abnormal_fetal_cardiomyocyte1.02207759
91MP0003633_abnormal_nervous_system1.01574960
92MP0002882_abnormal_neuron_morphology1.00801566
93MP0004215_abnormal_myocardial_fiber0.99850379
94MP0000747_muscle_weakness0.99539745
95MP0009780_abnormal_chondrocyte_physiolo0.99505533
96MP0002102_abnormal_ear_morphology0.98712932
97MP0005248_abnormal_Harderian_gland0.98604725
98MP0008932_abnormal_embryonic_tissue0.98414949
99MP0000639_abnormal_adrenal_gland0.97912861
100MP0003111_abnormal_nucleus_morphology0.97359718
101MP0002184_abnormal_innervation0.97037856
102MP0001145_abnormal_male_reproductive0.96607548
103MP0002127_abnormal_cardiovascular_syste0.95550609
104MP0004084_abnormal_cardiac_muscle0.95225193
105MP0003698_abnormal_male_reproductive0.93653042
106MP0000647_abnormal_sebaceous_gland0.93560738
107MP0000462_abnormal_digestive_system0.92841311
108MP0002161_abnormal_fertility/fecundity0.92512333
109MP0002971_abnormal_brown_adipose0.92294428
110MP0001672_abnormal_embryogenesis/_devel0.92226074
111MP0005380_embryogenesis_phenotype0.92226074
112MP0004142_abnormal_muscle_tone0.92038935
113MP0004130_abnormal_muscle_cell0.92006477
114MP0005174_abnormal_tail_pigmentation0.91645034
115MP0004270_analgesia0.91592914
116MP0000566_synostosis0.91263118
117MP0005266_abnormal_metabolism0.90939087
118MP0000653_abnormal_sex_gland0.90751997
119MP0002210_abnormal_sex_determination0.90335433
120MP0002572_abnormal_emotion/affect_behav0.90061377
121MP0002876_abnormal_thyroid_physiology0.89744806
122MP0002249_abnormal_larynx_morphology0.89523257
123MP0003631_nervous_system_phenotype0.89395032
124MP0005620_abnormal_muscle_contractility0.87434322
125MP0002095_abnormal_skin_pigmentation0.87310049
126MP0010630_abnormal_cardiac_muscle0.87227359
127MP0004185_abnormal_adipocyte_glucose0.87207358
128MP0002106_abnormal_muscle_physiology0.85895709
129MP0006035_abnormal_mitochondrial_morpho0.85874476
130MP0002282_abnormal_trachea_morphology0.85214371
131MP0004085_abnormal_heartbeat0.84631136
132MP0000383_abnormal_hair_follicle0.84627271
133MP0002066_abnormal_motor_capabilities/c0.84549781
134MP0004957_abnormal_blastocyst_morpholog0.84477304
135MP0003045_fibrosis0.83971086
136MP0000569_abnormal_digit_pigmentation0.83131976
137MP0004087_abnormal_muscle_fiber0.82108540
138MP0001340_abnormal_eyelid_morphology0.82024318
139MP0000778_abnormal_nervous_system0.81116243
140MP0005666_abnormal_adipose_tissue0.80265935
141MP0001730_embryonic_growth_arrest0.78700832
142MP0008569_lethality_at_weaning0.78439754
143MP0002108_abnormal_muscle_morphology0.77629676
144MP0003828_pulmonary_edema0.76722684
145MP0003635_abnormal_synaptic_transmissio0.76531057
146MP0001905_abnormal_dopamine_level0.76278007
147MP0001970_abnormal_pain_threshold0.76055020
148MP0004036_abnormal_muscle_relaxation0.75312184
149MP0002557_abnormal_social/conspecific_i0.75111343
150MP0000955_abnormal_spinal_cord0.74772297
151MP0004197_abnormal_fetal_growth/weight/0.73164738
152MP0005397_hematopoietic_system_phenotyp0.72824984
153MP0001545_abnormal_hematopoietic_system0.72824984
154MP0004134_abnormal_chest_morphology0.71350940
155MP0002152_abnormal_brain_morphology0.70995571
156MP0006292_abnormal_olfactory_placode0.70919445
157MP0005085_abnormal_gallbladder_physiolo0.70853690
158MP0004924_abnormal_behavior0.70206131
159MP0005386_behavior/neurological_phenoty0.70206131
160MP0003632_abnormal_nervous_system0.69509445
161MP0002972_abnormal_cardiac_muscle0.66078855

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.15273747
2Bony spicule pigmentary retinopathy (HP:0007737)6.26457899
3Amyotrophic lateral sclerosis (HP:0007354)5.50125402
4Chorioretinal atrophy (HP:0000533)4.92294380
5Abnormal rod and cone electroretinograms (HP:0008323)4.90000366
6Central scotoma (HP:0000603)4.56428306
7Absent rod-and cone-mediated responses on ERG (HP:0007688)4.54819162
8Papillary thyroid carcinoma (HP:0002895)4.36183691
9Male infertility (HP:0003251)4.35922489
10Abnormality of macular pigmentation (HP:0008002)4.33830852
11Facial hemangioma (HP:0000329)4.19625292
12Turricephaly (HP:0000262)4.13545154
13Poikiloderma (HP:0001029)4.11549591
14Pigmentary retinal degeneration (HP:0001146)3.95650719
15Pendular nystagmus (HP:0012043)3.92924463
16Concave nail (HP:0001598)3.86538070
17Hypochromic microcytic anemia (HP:0004840)3.85370461
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.85129800
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.85129800
20Scotoma (HP:0000575)3.79518861
21Attenuation of retinal blood vessels (HP:0007843)3.75221225
22Annular pancreas (HP:0001734)3.62635288
23Atrophy/Degeneration involving motor neurons (HP:0007373)3.60976613
24Rib fusion (HP:0000902)3.60045800
25Long clavicles (HP:0000890)3.59536732
26Abnormality of the corticospinal tract (HP:0002492)3.54671010
27Hepatoblastoma (HP:0002884)3.53540617
28Volvulus (HP:0002580)3.52638053
29Gaze-evoked nystagmus (HP:0000640)3.33270989
30Dyschromatopsia (HP:0007641)3.29623702
31Thyroid carcinoma (HP:0002890)3.27763861
32Aplasia/Hypoplasia of the sternum (HP:0006714)3.27259306
33Short chin (HP:0000331)3.06402269
34Abnormal hair whorl (HP:0010721)3.05578509
35Focal motor seizures (HP:0011153)3.03667726
36Abnormality of the anterior horn cell (HP:0006802)3.02632476
37Degeneration of anterior horn cells (HP:0002398)3.02632476
38Atonic seizures (HP:0010819)3.02109703
39Drooling (HP:0002307)3.01628544
40Choroideremia (HP:0001139)2.99134659
41Action tremor (HP:0002345)2.98459018
42Impaired vibration sensation in the lower limbs (HP:0002166)2.84026179
43Abolished electroretinogram (ERG) (HP:0000550)2.81394477
44Anteriorly placed anus (HP:0001545)2.81308757
45Excessive salivation (HP:0003781)2.81124409
46Medulloblastoma (HP:0002885)2.79578856
47Posterior subcapsular cataract (HP:0007787)2.79238482
48Capillary hemangiomas (HP:0005306)2.78755709
49Stomach cancer (HP:0012126)2.77221013
50Decreased central vision (HP:0007663)2.77176879
51Limb dystonia (HP:0002451)2.77083340
52Rectal fistula (HP:0100590)2.75002492
53Rectovaginal fistula (HP:0000143)2.75002492
54Pancreatic islet-cell hyperplasia (HP:0004510)2.74346083
55Cone-rod dystrophy (HP:0000548)2.71615905
56Type II diabetes mellitus (HP:0005978)2.71083734
57Increased IgM level (HP:0003496)2.68456103
58Dysdiadochokinesis (HP:0002075)2.66621475
59Long nose (HP:0003189)2.66355238
60Alopecia of scalp (HP:0002293)2.66264236
61Photophobia (HP:0000613)2.65691294
62Neoplasm of the heart (HP:0100544)2.62056058
63Focal seizures (HP:0007359)2.60616180
64Decreased lacrimation (HP:0000633)2.60495267
65Cortical dysplasia (HP:0002539)2.58127520
66Neoplasm of the oral cavity (HP:0100649)2.55499123
67Dialeptic seizures (HP:0011146)2.54461810
68Intestinal atresia (HP:0011100)2.53732678
69Intestinal fistula (HP:0100819)2.53318356
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.51220715
71Urinary urgency (HP:0000012)2.48811153
72Clumsiness (HP:0002312)2.46256583
73Short humerus (HP:0005792)2.45904535
74Retinitis pigmentosa (HP:0000510)2.45652684
75Abnormality of the lower motor neuron (HP:0002366)2.43495049
76Exercise-induced myalgia (HP:0003738)2.42838966
77Progressive cerebellar ataxia (HP:0002073)2.42741441
78Impaired vibratory sensation (HP:0002495)2.42094357
79Coronal craniosynostosis (HP:0004440)2.41014746
80Albinism (HP:0001022)2.40542117
81Split foot (HP:0001839)2.39877927
82Polyphagia (HP:0002591)2.39338236
83Severe visual impairment (HP:0001141)2.37994067
84Termporal pattern (HP:0011008)2.37482738
85Insidious onset (HP:0003587)2.37482738
86Morphological abnormality of the pyramidal tract (HP:0002062)2.37135375
87Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.36698334
88Tongue fasciculations (HP:0001308)2.31795612
89Vaginal fistula (HP:0004320)2.31105575
90Pustule (HP:0200039)2.30307852
91Clonus (HP:0002169)2.29901029
92Menstrual irregularities (HP:0000858)2.28559781
93Keratoconus (HP:0000563)2.28433528
94Increased corneal curvature (HP:0100692)2.28433528
95Gonadotropin excess (HP:0000837)2.26411113
96Aplasia/hypoplasia of the humerus (HP:0006507)2.25626833
97Intention tremor (HP:0002080)2.25175081
98Absent radius (HP:0003974)2.23220305
99Postural instability (HP:0002172)2.23075941
100Spastic gait (HP:0002064)2.22933255
101Astrocytoma (HP:0009592)2.22350213
102Abnormality of the astrocytes (HP:0100707)2.22350213
103Medial flaring of the eyebrow (HP:0010747)2.21757389
104Muscle fibrillation (HP:0010546)2.21409114
105Impaired social interactions (HP:0000735)2.21214396
106Abnormal social behavior (HP:0012433)2.21214396
107Alacrima (HP:0000522)2.19466918
108Abnormality of the motor neurons (HP:0002450)2.19190478
109Abnormal neuron morphology (HP:0012757)2.19190478
110Ankle clonus (HP:0011448)2.18904402
111Macular degeneration (HP:0000608)2.18341693
112Lower limb muscle weakness (HP:0007340)2.16792814
113Labial hypoplasia (HP:0000066)2.16276667
114Ulnar bowing (HP:0003031)2.16171303
115Genital tract atresia (HP:0001827)2.14357063
116Broad-based gait (HP:0002136)2.13323816
117Gait ataxia (HP:0002066)2.12679092
118Abnormality of salivation (HP:0100755)2.12469773
119Congenital hip dislocation (HP:0001374)2.11993023
120Short phalanx of the thumb (HP:0009660)2.11182875
121Abnormal hemoglobin (HP:0011902)2.10518840
122Broad alveolar ridges (HP:0000187)2.09931611
123Hamartoma (HP:0010566)2.08206194
124Failure to thrive in infancy (HP:0001531)2.06650904
125Megalencephaly (HP:0001355)2.05991831
126Hypoplastic labia majora (HP:0000059)2.04989692
127Aplasia involving forearm bones (HP:0009822)2.04393730
128Absent forearm bone (HP:0003953)2.04393730
129Upper motor neuron abnormality (HP:0002127)2.04002507
130Vaginal atresia (HP:0000148)2.01313917
131Hyperventilation (HP:0002883)1.98332555
132Rimmed vacuoles (HP:0003805)1.95640517
133Thickened helices (HP:0000391)1.93600866
134Germ cell neoplasia (HP:0100728)1.92618144
135Abnormality of male internal genitalia (HP:0000022)1.92240618
136Large for gestational age (HP:0001520)1.91817681
137Febrile seizures (HP:0002373)1.91045671
138Gait imbalance (HP:0002141)1.90472317
139Epileptic encephalopathy (HP:0200134)1.90300006
140Premature skin wrinkling (HP:0100678)1.90102288
141Abnormality of the aortic arch (HP:0012303)1.89085278
142Choanal stenosis (HP:0000452)1.87184427
143Absence seizures (HP:0002121)1.86634286
144Orthostatic hypotension (HP:0001278)1.86576860
145Nephrogenic diabetes insipidus (HP:0009806)1.86542170
146Resting tremor (HP:0002322)1.86116151
147Abnormal respiratory motile cilium morphology (HP:0005938)1.85510190
148Abnormal respiratory epithelium morphology (HP:0012253)1.85510190
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85416330
150Abnormality of alanine metabolism (HP:0010916)1.85416330
151Hyperalaninemia (HP:0003348)1.85416330
152Split hand (HP:0001171)1.85208236
153Curly hair (HP:0002212)1.83587575
154Urinary bladder sphincter dysfunction (HP:0002839)1.83390049
155Abnormality of the labia majora (HP:0012881)1.83138913
156Progressive inability to walk (HP:0002505)1.82770888
157Gonadal dysgenesis (HP:0000133)1.82673968
158Inappropriate behavior (HP:0000719)1.81997945
159Generalized tonic-clonic seizures (HP:0002069)1.81404210
160Hypotelorism (HP:0000601)1.81225172
161Aqueductal stenosis (HP:0002410)1.81220050
162Abnormality of the musculature of the pelvis (HP:0001469)1.81083128
163Abnormality of the hip-girdle musculature (HP:0001445)1.81083128
164Small hand (HP:0200055)1.80879539
165Infertility (HP:0000789)1.80417148
166Congenital primary aphakia (HP:0007707)1.80199806
167Hypsarrhythmia (HP:0002521)1.79954171
168Hypoplastic female external genitalia (HP:0012815)1.79566366
169Blue irides (HP:0000635)1.78398492
170Epileptiform EEG discharges (HP:0011182)1.77052709
171Dysautonomia (HP:0002459)1.76540417
172Abnormality of the pubic bones (HP:0003172)1.76465970
173Scanning speech (HP:0002168)1.75814551
174Oligodactyly (hands) (HP:0001180)1.75623313
175EEG with generalized epileptiform discharges (HP:0011198)1.75437276
176Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75265948
177Short 1st metacarpal (HP:0010034)1.75265948
178Hip dysplasia (HP:0001385)1.73088845
179Visual hallucinations (HP:0002367)1.73033747
180Fetal akinesia sequence (HP:0001989)1.71348143
181Abnormality of the labia minora (HP:0012880)1.69161149
182Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67430044
183Patellar aplasia (HP:0006443)1.67398465
184Absent thumb (HP:0009777)1.66275794
185Vitreoretinal degeneration (HP:0000655)1.62710874
186Bulbar palsy (HP:0001283)1.62694424
187Narrow nasal bridge (HP:0000446)1.62340981
188Constricted visual fields (HP:0001133)1.62236601
189Subcapsular cataract (HP:0000523)1.61945552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.82984017
2MAP3K64.70343656
3MAP4K24.02104285
4MAPK153.87354845
5DDR23.78255948
6BCR3.40487414
7TRIM282.91781386
8TYRO32.71391904
9ERBB32.45712768
10FGR2.42002941
11MAP3K112.27279510
12LATS22.22352467
13MATK2.13105693
14PRKD22.08429242
15LATS12.08258493
16DAPK12.01009732
17CASK1.99338761
18MAP2K71.97319007
19MAP2K41.92460392
20MAP3K91.85490462
21SIK31.79609174
22DYRK1B1.78525927
23WNK31.74983951
24PHKG11.71302211
25PHKG21.71302211
26MINK11.70441317
27UHMK11.61916099
28EIF2AK31.57669948
29MAPK131.52826641
30PNCK1.50803407
31CAMK1G1.50380593
32RAF11.45852077
33YES11.42044014
34PDGFRA1.39913586
35DYRK31.38692030
36TRPM71.36494008
37PAK61.34837032
38CSK1.32688986
39PDK41.32307659
40PDK31.32307659
41OBSCN1.32114732
42CDK71.30320614
43STK381.28241431
44CHEK21.27592290
45BMX1.27078742
46AKT31.26906454
47CSNK1A1L1.26587210
48CCNB11.25329739
49FRK1.24234640
50PRPF4B1.23982519
51NEK11.21280455
52TNIK1.19326369
53KSR21.15228099
54RPS6KC11.14166220
55RPS6KL11.14166220
56PRKAA11.08874682
57CAMK1D1.08821467
58MAP3K121.08253583
59NEK91.02943260
60STK38L1.01955730
61NTRK31.01680040
62NEK61.01321967
63CDK61.01218785
64EPHA40.99060638
65PAK30.98991101
66PLK20.98638988
67FGFR20.96437491
68STK30.95342238
69MAP3K50.93630915
70DYRK1A0.93227432
71HIPK20.91903667
72RPS6KA60.90061932
73DAPK20.89040034
74STK390.87601611
75MUSK0.86073622
76TAOK20.82107884
77NEK20.81551528
78SCYL20.81418454
79CSNK1G10.80675496
80PRKCE0.80394348
81MAPK70.80175410
82MOS0.79430784
83CAMKK20.79301373
84RPS6KA40.77771705
85CAMK2D0.75369158
86GSK3A0.74345761
87GRK10.73664549
88CDC42BPA0.72827602
89SGK20.71441410
90NTRK20.69816071
91MAP3K20.69052145
92WNK10.68337757
93RIPK40.67853825
94PLK10.67508268
95CAMK2A0.64918612
96OXSR10.64448420
97MAP3K40.64316205
98BRD40.64088091
99DYRK20.63485029
100PDK20.62476214
101MTOR0.62445173
102MAPK110.60996670
103PIK3CG0.60565689
104CAMK2B0.59923317
105CAMK2G0.59805488
106ACVR1B0.58655675
107PRKAA20.58474118
108BMPR20.57559295
109MARK20.56577134
110* PINK10.55622837
111FER0.55206255
112CSNK1G20.54610503
113TTK0.54521425
114EGFR0.53826270
115SGK2230.53712724
116SGK4940.53712724
117MAPK100.53068773
118TAOK30.51821107
119TNK20.50844550
120PRKD30.50771375
121PIM20.49659959
122SIK20.48862992
123PRKCG0.48818840
124FGFR30.48261634
125PIM10.46671886
126CDK180.45881557
127MAPKAPK50.45394574
128AURKA0.45116253
129RET0.44221283
130INSRR0.43963232
131KSR10.43718281
132BMPR1B0.43683411
133SGK10.43388428
134JAK20.43096530
135DMPK0.42406006
136RPS6KA30.42131209
137MARK10.41901667
138CDC70.41642493
139FLT30.41541323
140EPHA30.41116579
141BCKDK0.40120100
142FGFR10.38657146
143CDK90.38524773
144CDK20.37614210
145NUAK10.37275613
146CAMK10.36655106
147CAMKK10.36524442
148ATM0.36176439
149SGK30.35753521
150CSNK1D0.35218415
151PRKACB0.34436444
152CSNK1G30.34418236
153MARK30.34244140
154WEE10.33567321
155ATR0.33505282
156MAPK140.33438931
157RPS6KB10.33433660
158PRKG10.33143681
159RPS6KB20.32619025
160PRKD10.32360276
161CDK140.31963916
162MAPK10.30624246
163BRAF0.30392872
164CDK10.29935620
165PRKCZ0.28061411
166RPS6KA10.27410279
167CDK150.27309122
168TAOK10.26791506
169CHEK10.26418960
170CDK50.26367010
171MAPK30.25473190

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.81950669
2Fatty acid biosynthesis_Homo sapiens_hsa000614.23652642
3Circadian rhythm_Homo sapiens_hsa047103.24866330
4Mismatch repair_Homo sapiens_hsa034302.52795928
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.09862472
6Base excision repair_Homo sapiens_hsa034102.00040404
7mTOR signaling pathway_Homo sapiens_hsa041501.98743349
8Cocaine addiction_Homo sapiens_hsa050301.89433879
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74243981
10Taste transduction_Homo sapiens_hsa047421.73808915
11Oocyte meiosis_Homo sapiens_hsa041141.68042182
12Salivary secretion_Homo sapiens_hsa049701.67763783
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66753114
14Biosynthesis of amino acids_Homo sapiens_hsa012301.62106839
15DNA replication_Homo sapiens_hsa030301.61494216
16Steroid biosynthesis_Homo sapiens_hsa001001.55405643
17Non-homologous end-joining_Homo sapiens_hsa034501.51957478
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51634217
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.50585944
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46345866
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42054585
22Inositol phosphate metabolism_Homo sapiens_hsa005621.41150508
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39608684
24Hippo signaling pathway_Homo sapiens_hsa043901.39344057
25Nucleotide excision repair_Homo sapiens_hsa034201.38856695
26Arginine and proline metabolism_Homo sapiens_hsa003301.38325618
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36160084
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35764837
29Hedgehog signaling pathway_Homo sapiens_hsa043401.31761261
30Gastric acid secretion_Homo sapiens_hsa049711.31331211
31Fatty acid metabolism_Homo sapiens_hsa012121.31036866
32GABAergic synapse_Homo sapiens_hsa047271.25286888
33Fanconi anemia pathway_Homo sapiens_hsa034601.20006786
34Wnt signaling pathway_Homo sapiens_hsa043101.18598890
35mRNA surveillance pathway_Homo sapiens_hsa030151.17553380
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16481667
37Choline metabolism in cancer_Homo sapiens_hsa052311.14063828
38Nicotine addiction_Homo sapiens_hsa050331.13831599
39Dorso-ventral axis formation_Homo sapiens_hsa043201.13133558
40Cell cycle_Homo sapiens_hsa041101.11709651
41Sulfur relay system_Homo sapiens_hsa041221.11518349
42Butanoate metabolism_Homo sapiens_hsa006501.10911007
43Folate biosynthesis_Homo sapiens_hsa007901.09831485
44Adherens junction_Homo sapiens_hsa045201.08867626
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07849877
46AMPK signaling pathway_Homo sapiens_hsa041521.07752718
47Arginine biosynthesis_Homo sapiens_hsa002201.05489714
48Regulation of autophagy_Homo sapiens_hsa041401.05363707
49Prolactin signaling pathway_Homo sapiens_hsa049171.05186415
50RNA transport_Homo sapiens_hsa030131.03553976
51Axon guidance_Homo sapiens_hsa043601.01080945
52Oxytocin signaling pathway_Homo sapiens_hsa049210.97358949
53VEGF signaling pathway_Homo sapiens_hsa043700.96329617
54Protein export_Homo sapiens_hsa030600.93549301
55Lysine degradation_Homo sapiens_hsa003100.93021202
56Gap junction_Homo sapiens_hsa045400.91181753
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88963152
58TGF-beta signaling pathway_Homo sapiens_hsa043500.88309078
59Nitrogen metabolism_Homo sapiens_hsa009100.86880063
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86497082
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85027588
62Glucagon signaling pathway_Homo sapiens_hsa049220.84847359
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.84767565
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84618908
65Platelet activation_Homo sapiens_hsa046110.83852256
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82109989
67Propanoate metabolism_Homo sapiens_hsa006400.81245252
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80423018
69Glutamatergic synapse_Homo sapiens_hsa047240.80200430
70p53 signaling pathway_Homo sapiens_hsa041150.80062864
71Olfactory transduction_Homo sapiens_hsa047400.79708174
72Insulin signaling pathway_Homo sapiens_hsa049100.78929089
73Long-term potentiation_Homo sapiens_hsa047200.78132892
74Morphine addiction_Homo sapiens_hsa050320.77871817
75Notch signaling pathway_Homo sapiens_hsa043300.77769515
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77669407
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.77358464
78Fructose and mannose metabolism_Homo sapiens_hsa000510.76080688
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75634026
80ErbB signaling pathway_Homo sapiens_hsa040120.75581567
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75471179
82Circadian entrainment_Homo sapiens_hsa047130.75058359
83Type II diabetes mellitus_Homo sapiens_hsa049300.74290765
84Alcoholism_Homo sapiens_hsa050340.73763117
85GnRH signaling pathway_Homo sapiens_hsa049120.73709027
86Long-term depression_Homo sapiens_hsa047300.73388979
87Colorectal cancer_Homo sapiens_hsa052100.72461647
88Dopaminergic synapse_Homo sapiens_hsa047280.70708099
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70251822
90Tight junction_Homo sapiens_hsa045300.69146674
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68979707
92Glioma_Homo sapiens_hsa052140.68171573
93Homologous recombination_Homo sapiens_hsa034400.67701867
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67647709
95Calcium signaling pathway_Homo sapiens_hsa040200.65270043
96Collecting duct acid secretion_Homo sapiens_hsa049660.61899075
97Synaptic vesicle cycle_Homo sapiens_hsa047210.61450564
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.61196186
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60977176
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60407829
101Amphetamine addiction_Homo sapiens_hsa050310.60402409
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60046695
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59907631
104Renin secretion_Homo sapiens_hsa049240.58454794
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57671186
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55384731
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54469351
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54037486
109Estrogen signaling pathway_Homo sapiens_hsa049150.53767383
110Rap1 signaling pathway_Homo sapiens_hsa040150.53743825
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53638518
112Carbon metabolism_Homo sapiens_hsa012000.53581522
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53249053
114Ras signaling pathway_Homo sapiens_hsa040140.53043176
115RNA degradation_Homo sapiens_hsa030180.51734081
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50376664
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50136362
118Ovarian steroidogenesis_Homo sapiens_hsa049130.49750654
119Melanogenesis_Homo sapiens_hsa049160.49635938
120Pyruvate metabolism_Homo sapiens_hsa006200.49563834
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49456936
122Cardiac muscle contraction_Homo sapiens_hsa042600.49311275
123Ether lipid metabolism_Homo sapiens_hsa005650.49055097
124Glycerolipid metabolism_Homo sapiens_hsa005610.48722431
125HIF-1 signaling pathway_Homo sapiens_hsa040660.48009161
126MicroRNAs in cancer_Homo sapiens_hsa052060.46227065
127Cholinergic synapse_Homo sapiens_hsa047250.46003034
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45862037
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.45227390
130African trypanosomiasis_Homo sapiens_hsa051430.44990750
131Endometrial cancer_Homo sapiens_hsa052130.44711701
132Basal transcription factors_Homo sapiens_hsa030220.44560758
133MAPK signaling pathway_Homo sapiens_hsa040100.43780850
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.42907215
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41410344
136Pancreatic secretion_Homo sapiens_hsa049720.41224201
137Basal cell carcinoma_Homo sapiens_hsa052170.40470568
138cAMP signaling pathway_Homo sapiens_hsa040240.39681358
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.39126575
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37034055
141Spliceosome_Homo sapiens_hsa030400.36365894
142Renal cell carcinoma_Homo sapiens_hsa052110.36315152
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.35685319
144Vitamin B6 metabolism_Homo sapiens_hsa007500.35160111
145Insulin secretion_Homo sapiens_hsa049110.35008398
146Serotonergic synapse_Homo sapiens_hsa047260.34858160
147FoxO signaling pathway_Homo sapiens_hsa040680.34413257

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