RHOT1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)6.42605767
2positive regulation of protein kinase C signaling (GO:0090037)5.61238114
3insulin-like growth factor receptor signaling pathway (GO:0048009)5.35153129
4regulation of ER to Golgi vesicle-mediated transport (GO:0060628)5.07662432
5negative regulation of oligodendrocyte differentiation (GO:0048715)5.02544094
6phosphatidylethanolamine metabolic process (GO:0046337)4.55064877
7atrioventricular valve morphogenesis (GO:0003181)4.43337764
8nephron tubule morphogenesis (GO:0072078)4.35277194
9nephron epithelium morphogenesis (GO:0072088)4.35277194
10proximal/distal pattern formation (GO:0009954)4.33126774
11startle response (GO:0001964)4.11521037
12glucocorticoid biosynthetic process (GO:0006704)3.99178481
13glutathione biosynthetic process (GO:0006750)3.85184931
14phosphatidylethanolamine biosynthetic process (GO:0006646)3.75888896
15positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.72011365
16CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.68613350
17behavioral response to ethanol (GO:0048149)3.68489525
18mitotic G1/S transition checkpoint (GO:0044819)3.55323814
19forebrain morphogenesis (GO:0048853)3.52184153
20positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.46623568
21interferon-gamma secretion (GO:0072643)3.45077071
22mitotic G1 DNA damage checkpoint (GO:0031571)3.44162848
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.43929170
24mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.42566718
25positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.42566718
26nonribosomal peptide biosynthetic process (GO:0019184)3.41810323
27peptidyl-lysine dimethylation (GO:0018027)3.39031579
28leukotriene biosynthetic process (GO:0019370)3.37477762
29musculoskeletal movement (GO:0050881)3.36875013
30multicellular organismal movement (GO:0050879)3.36875013
31regulation of synapse maturation (GO:0090128)3.36580942
32phosphatidylcholine biosynthetic process (GO:0006656)3.33344786
33behavioral response to nicotine (GO:0035095)3.31930284
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28861217
35gastrulation with mouth forming second (GO:0001702)3.24398038
36regulation of ARF GTPase activity (GO:0032312)3.21904877
37glycerophospholipid catabolic process (GO:0046475)3.21493369
38transcription from mitochondrial promoter (GO:0006390)3.18804180
39lung epithelium development (GO:0060428)3.15543731
40positive regulation of synapse maturation (GO:0090129)3.12237236
41cilium or flagellum-dependent cell motility (GO:0001539)3.10202527
42renal tubule morphogenesis (GO:0061333)3.09632584
43protein targeting to Golgi (GO:0000042)3.07394633
44negative regulation of glucose import (GO:0046325)3.05966589
45transepithelial transport (GO:0070633)3.04044586
46establishment of protein localization to Golgi (GO:0072600)3.01397457
47histone H3-K9 methylation (GO:0051567)2.99825985
48acrosome reaction (GO:0007340)2.99068718
49ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.97897626
50regulation of apoptotic cell clearance (GO:2000425)2.94739561
51COPI coating of Golgi vesicle (GO:0048205)2.94232153
52Golgi transport vesicle coating (GO:0048200)2.94232153
53intestinal cholesterol absorption (GO:0030299)2.94183117
54establishment of mitochondrion localization (GO:0051654)2.93755067
55regulation of protein kinase C signaling (GO:0090036)2.93411157
56methionine biosynthetic process (GO:0009086)2.92838923
57peptidyl-lysine trimethylation (GO:0018023)2.91712559
58phosphatidylglycerol biosynthetic process (GO:0006655)2.91553663
59histone H3-K9 demethylation (GO:0033169)2.89719110
60heart valve formation (GO:0003188)2.89714167
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88752681
62mitochondrion transport along microtubule (GO:0047497)2.88752681
63seminiferous tubule development (GO:0072520)2.87412257
64positive regulation of CREB transcription factor activity (GO:0032793)2.86612193
65regulation of telomere maintenance (GO:0032204)2.85674665
66megakaryocyte development (GO:0035855)2.83376657
67negative regulation of glial cell differentiation (GO:0045686)2.82787310
68positive regulation of heat generation (GO:0031652)2.82671296
69ribosome assembly (GO:0042255)2.81365065
70response to food (GO:0032094)2.79380002
71peptidyl-lysine methylation (GO:0018022)2.77575843
72multicellular organism reproduction (GO:0032504)2.76697128
73G1 DNA damage checkpoint (GO:0044783)2.72604629
74proline metabolic process (GO:0006560)2.72100228
75negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.72080319
76retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.71653653
77positive regulation of mitochondrial membrane permeability (GO:0035794)2.70558891
78histone lysine demethylation (GO:0070076)2.70153629
79semaphorin-plexin signaling pathway (GO:0071526)2.68946709
80retrograde transport, endosome to Golgi (GO:0042147)2.68758146
81entrainment of circadian clock by photoperiod (GO:0043153)2.66718235
82protein localization to Golgi apparatus (GO:0034067)2.64244232
83histone H3-K4 trimethylation (GO:0080182)2.63975642
84retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62486088
85negative regulation of astrocyte differentiation (GO:0048712)2.60328470
86negative regulation of glucose transport (GO:0010829)2.59063997
87histone demethylation (GO:0016577)2.58376398
88sex determination (GO:0007530)2.57514364
89negative regulation of viral release from host cell (GO:1902187)2.54703954
90regulation of oligodendrocyte differentiation (GO:0048713)2.53973875
91mitotic cell cycle arrest (GO:0071850)2.53267274
92histone H3-K9 modification (GO:0061647)2.51787312
93Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48747959
94protein demethylation (GO:0006482)2.48201043
95protein dealkylation (GO:0008214)2.48201043
96positive regulation of hormone metabolic process (GO:0032352)2.47774267
97positive regulation of DNA-dependent DNA replication (GO:2000105)2.46711273
98response to pheromone (GO:0019236)2.45869499
99pattern specification involved in kidney development (GO:0061004)17.5699650
100segment specification (GO:0007379)10.1579818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.72842069
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.03583162
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.28098242
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.25050510
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.90308550
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.47413595
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42328667
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.25113600
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.21536712
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20770270
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.17365396
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93978122
13ZNF274_21170338_ChIP-Seq_K562_Hela1.92925258
14P68_20966046_ChIP-Seq_HELA_Human1.90509970
15ERG_21242973_ChIP-ChIP_JURKAT_Human1.82469896
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.79564256
17DROSHA_22980978_ChIP-Seq_HELA_Human1.78776746
18E2F1_20622854_ChIP-Seq_HELA_Human1.77907757
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.77712298
20ZNF263_19887448_ChIP-Seq_K562_Human1.75513177
21GABP_19822575_ChIP-Seq_HepG2_Human1.72079689
22KDM2B_26808549_Chip-Seq_DND41_Human1.68368314
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64569073
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61877744
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56918322
26EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56239753
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.54680338
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.51189156
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47473702
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.46109059
31AR_21572438_ChIP-Seq_LNCaP_Human1.45208380
32GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45027199
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42973275
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39314932
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39130503
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37002773
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36781172
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34968166
39BCOR_27268052_Chip-Seq_Bcells_Human1.29918468
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29463920
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28915216
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27810555
43PHF8_20622854_ChIP-Seq_HELA_Human1.26710456
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25705644
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.23993627
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22241630
47CREB1_26743006_Chip-Seq_LNCaP_Human1.22191990
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22122619
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.20148693
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19415227
51LXR_22292898_ChIP-Seq_THP-1_Human1.18731166
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18129798
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18129798
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18129798
55KDM5A_27292631_Chip-Seq_BREAST_Human1.16969920
56TP53_22127205_ChIP-Seq_IMR90_Human1.15284871
57KDM2B_26808549_Chip-Seq_K562_Human1.13347631
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13266222
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11629763
60RARB_24833708_ChIP-Seq_LIVER_Mouse1.11549139
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10419845
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09772812
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09772812
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07580898
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07366912
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06772542
67LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06769804
68MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06515055
69CIITA_25753668_ChIP-Seq_RAJI_Human1.06344149
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06304228
71RACK7_27058665_Chip-Seq_MCF-7_Human1.05225307
72BCL6_27268052_Chip-Seq_Bcells_Human1.04832990
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04366856
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04248977
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04188234
76RARA_24833708_ChIP-Seq_LIVER_Mouse1.02448934
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02178494
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.01758691
79CTCF_27219007_Chip-Seq_Bcells_Human1.01651208
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01495432
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.00448785
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.00113747
83TET1_21490601_ChIP-Seq_MESCs_Mouse0.99941831
84VDR_22108803_ChIP-Seq_LS180_Human0.99655939
85ERA_21632823_ChIP-Seq_H3396_Human0.99323463
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98547495
87FOXP1_21924763_ChIP-Seq_HESCs_Human0.97792383
88SMC4_20622854_ChIP-Seq_HELA_Human0.97777648
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97440657
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97127930
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93359878
92SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92680116
93RARB_27405468_Chip-Seq_BRAIN_Mouse0.92552304
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89854539
95IRF1_19129219_ChIP-ChIP_H3396_Human0.88461450
96MAF_26560356_Chip-Seq_TH2_Human0.88331897
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88212322
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88043700
99GBX2_23144817_ChIP-Seq_PC3_Human0.87832366
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87261213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.14366467
2MP0003195_calcinosis3.78866454
3MP0008260_abnormal_autophagy3.60426684
4MP0003787_abnormal_imprinting3.39002592
5MP0005248_abnormal_Harderian_gland3.12556690
6MP0003122_maternal_imprinting2.74241764
7MP0004381_abnormal_hair_follicle2.66814816
8MP0002653_abnormal_ependyma_morphology2.65855203
9MP0004133_heterotaxia2.65139238
10MP0005360_urolithiasis2.42867204
11MP0003121_genomic_imprinting2.41255605
12MP0002234_abnormal_pharynx_morphology2.32222057
13MP0003941_abnormal_skin_development2.31106295
14MP0003172_abnormal_lysosome_physiology2.30742350
15MP0006292_abnormal_olfactory_placode2.23798691
16MP0000778_abnormal_nervous_system2.18192812
17MP0001529_abnormal_vocalization2.11707046
18MP0003183_abnormal_peptide_metabolism2.09498820
19MP0002249_abnormal_larynx_morphology2.04237889
20MP0001502_abnormal_circadian_rhythm1.94634691
21MP0009384_cardiac_valve_regurgitation1.80262852
22MP0002876_abnormal_thyroid_physiology1.78579813
23MP0000566_synostosis1.72514498
24MP0005058_abnormal_lysosome_morphology1.71331011
25MP0005503_abnormal_tendon_morphology1.65092273
26MP0000371_diluted_coat_color1.59460545
27MP0001958_emphysema1.59058677
28MP0003942_abnormal_urinary_system1.51225592
29MP0003115_abnormal_respiratory_system1.45554513
30MP0002282_abnormal_trachea_morphology1.29917250
31MP0002933_joint_inflammation1.26569815
32MP0000631_abnormal_neuroendocrine_gland1.24870506
33MP0003221_abnormal_cardiomyocyte_apopto1.21163070
34MP0000013_abnormal_adipose_tissue1.20996011
35MP0004233_abnormal_muscle_weight1.19424435
36MP0005410_abnormal_fertilization1.18162344
37MP0009046_muscle_twitch1.16746387
38MP0001984_abnormal_olfaction1.16255202
39MP0003632_abnormal_nervous_system1.15111664
40MP0004043_abnormal_pH_regulation1.14449474
41MP0000678_abnormal_parathyroid_gland1.13960257
42MP0005670_abnormal_white_adipose1.10927595
43MP0002108_abnormal_muscle_morphology1.09033423
44MP0003385_abnormal_body_wall1.08852295
45MP0002229_neurodegeneration1.08254171
46MP0000733_abnormal_muscle_development1.07966339
47MP0002132_abnormal_respiratory_system1.07962110
48MP0002184_abnormal_innervation1.05520333
49MP0005076_abnormal_cell_differentiation1.03586985
50MP0004264_abnormal_extraembryonic_tissu1.02806720
51MP0000026_abnormal_inner_ear1.01531635
52MP0010329_abnormal_lipoprotein_level1.00821370
53MP0008995_early_reproductive_senescence0.97789923
54MP0002752_abnormal_somatic_nervous0.97023991
55MP0003879_abnormal_hair_cell0.93738373
56MP0003943_abnormal_hepatobiliary_system0.93311696
57MP0000681_abnormal_thyroid_gland0.90743720
58MP0003861_abnormal_nervous_system0.90704926
59MP0001188_hyperpigmentation0.90039242
60MP0000751_myopathy0.88320470
61MP0002882_abnormal_neuron_morphology0.87911316
62MP0002168_other_aberrant_phenotype0.87552693
63MP0000639_abnormal_adrenal_gland0.87528909
64MP0010368_abnormal_lymphatic_system0.85427871
65MP0004858_abnormal_nervous_system0.84487191
66MP0004134_abnormal_chest_morphology0.81562078
67MP0005551_abnormal_eye_electrophysiolog0.80024136
68MP0001299_abnormal_eye_distance/0.79855512
69MP0000049_abnormal_middle_ear0.79125909
70MP0001968_abnormal_touch/_nociception0.77836619
71MP0003938_abnormal_ear_development0.77708100
72MP0005409_darkened_coat_color0.73468601
73MP0000383_abnormal_hair_follicle0.72141171
74MP0001666_abnormal_nutrient_absorption0.70628421
75MP0002822_catalepsy0.70158645
76MP0004859_abnormal_synaptic_plasticity0.70013556
77MP0008875_abnormal_xenobiotic_pharmacok0.69475183
78MP0002925_abnormal_cardiovascular_devel0.67163633
79MP0000955_abnormal_spinal_cord0.66672939
80MP0003119_abnormal_digestive_system0.66618359
81MP0005266_abnormal_metabolism0.63994916
82MP0002152_abnormal_brain_morphology0.63589602
83MP0003959_abnormal_lean_body0.63542338
84MP0005647_abnormal_sex_gland0.62315411
85MP0002084_abnormal_developmental_patter0.61090859
86MP0000767_abnormal_smooth_muscle0.60965947
87MP0001879_abnormal_lymphatic_vessel0.60766085
88MP0008007_abnormal_cellular_replicative0.60371467
89MP0001286_abnormal_eye_development0.60137427
90MP0001270_distended_abdomen0.60107380
91MP0005085_abnormal_gallbladder_physiolo0.58983815
92MP0003948_abnormal_gas_homeostasis0.58593635
93MP0005395_other_phenotype0.58019605
94MP0002557_abnormal_social/conspecific_i0.55291983
95MP0002116_abnormal_craniofacial_bone0.55011051
96MP0003755_abnormal_palate_morphology0.54832156
97MP0000516_abnormal_urinary_system0.54752341
98MP0005367_renal/urinary_system_phenotyp0.54752341
99MP0001849_ear_inflammation0.54277298
100MP0005365_abnormal_bile_salt0.53848862

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.53648041
2J-shaped sella turcica (HP:0002680)4.84030188
3Severe Myopia (HP:0011003)4.83712134
4Broad alveolar ridges (HP:0000187)4.08984918
5Deep venous thrombosis (HP:0002625)3.88032279
6Postural instability (HP:0002172)3.70704147
7Nuclear cataract (HP:0100018)3.69252363
8Broad face (HP:0000283)3.50646971
9Mitral stenosis (HP:0001718)3.45668066
10Renal salt wasting (HP:0000127)3.42585079
11Resting tremor (HP:0002322)3.40160768
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.37013982
13Infantile muscular hypotonia (HP:0008947)3.16989685
14Neonatal respiratory distress (HP:0002643)3.14400717
15Genetic anticipation (HP:0003743)3.08428082
16Volvulus (HP:0002580)3.04902537
17Tapered finger (HP:0001182)2.80734912
18Vitreoretinal degeneration (HP:0000655)2.72542482
19Upper limb muscle weakness (HP:0003484)2.65774923
20Renal cell carcinoma (HP:0005584)2.64645982
21Midline defect of the nose (HP:0004122)2.64242903
22Hypochromic microcytic anemia (HP:0004840)2.63451458
23Hypochromic anemia (HP:0001931)2.61201799
24Aortic regurgitation (HP:0001659)2.59269319
25Supernumerary spleens (HP:0009799)2.55566567
26Hand muscle atrophy (HP:0009130)2.54700473
27Tented upper lip vermilion (HP:0010804)2.51960795
28Exocrine pancreatic insufficiency (HP:0001738)2.51278874
29Hypercortisolism (HP:0001578)2.51039777
30Split foot (HP:0001839)2.46832844
31Lymphangioma (HP:0100764)2.44375141
32Upper limb amyotrophy (HP:0009129)2.43766980
33Distal upper limb amyotrophy (HP:0007149)2.43766980
34Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42573232
35Absent frontal sinuses (HP:0002688)2.42560169
36Shawl scrotum (HP:0000049)2.41233550
37Aplasia/Hypoplasia of the clavicles (HP:0006710)2.40118098
38Deformed sella turcica (HP:0002681)2.37504861
39Pustule (HP:0200039)2.32916945
40Cervical subluxation (HP:0003308)2.31367888
41Peripheral hypomyelination (HP:0007182)2.30094768
42Small epiphyses (HP:0010585)2.27770368
43Exotropia (HP:0000577)2.27622314
44Myopathic facies (HP:0002058)2.25307805
45Adactyly (HP:0009776)2.24112757
46Abnormality of the aortic arch (HP:0012303)2.22994394
47Hemorrhage of the eye (HP:0011885)2.15072697
48Hypoplastic ischia (HP:0003175)2.11578638
49Flared iliac wings (HP:0002869)2.11428008
50Aortic valve stenosis (HP:0001650)2.05738858
51Abnormality of the femoral head (HP:0003368)2.04773575
52Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.04489042
53Short clavicles (HP:0000894)1.99929196
54Broad palm (HP:0001169)1.97294764
55Renal dysplasia (HP:0000110)1.95800222
56Aplasia/Hypoplasia of the uvula (HP:0010293)1.94447195
57Increased number of teeth (HP:0011069)1.94263043
58Supernumerary bones of the axial skeleton (HP:0009144)1.92677584
59Round ear (HP:0100830)1.92484346
60Absent epiphyses (HP:0010577)1.92335980
61Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92335980
62Prolonged partial thromboplastin time (HP:0003645)1.90999271
63Abnormality of the astrocytes (HP:0100707)1.89988827
64Astrocytoma (HP:0009592)1.89988827
65True hermaphroditism (HP:0010459)1.86990410
66Supernumerary ribs (HP:0005815)1.85134100
67Insidious onset (HP:0003587)1.84403693
68Termporal pattern (HP:0011008)1.84403693
69Diastasis recti (HP:0001540)1.84034687
70Abnormality of the alveolar ridges (HP:0006477)1.83234492
71Abnormality of the pubic bones (HP:0003172)1.82310026
72Abnormality of the ileum (HP:0001549)1.81234139
73Meckel diverticulum (HP:0002245)1.81095075
74Menorrhagia (HP:0000132)1.79096739
75Abnormality of the musculature of the hand (HP:0001421)1.78981980
76Joint hemorrhage (HP:0005261)1.78827773
77Cystic liver disease (HP:0006706)1.78507153
78Aplasia/hypoplasia of the femur (HP:0005613)1.77536263
79Male pseudohermaphroditism (HP:0000037)1.76721477
80Gonadal dysgenesis (HP:0000133)1.76494664
81Poor coordination (HP:0002370)1.74844311
82Scrotal hypoplasia (HP:0000046)1.74096924
83Urinary urgency (HP:0000012)1.73912926
84Macroorchidism (HP:0000053)1.73406300
85Hyperkalemia (HP:0002153)1.72022116
86Nephronophthisis (HP:0000090)1.71678600
87Thin bony cortex (HP:0002753)1.70874467
88Oligodactyly (hands) (HP:0001180)1.70458752
89Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.69248003
90Reticulocytosis (HP:0001923)1.68730887
91Delayed myelination (HP:0012448)1.68390860
92Abnormality of femoral epiphyses (HP:0006499)1.67913086
93Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.67913086
94Partial duplication of thumb phalanx (HP:0009944)1.67909618
95Intestinal atresia (HP:0011100)1.67774976
96Dysdiadochokinesis (HP:0002075)1.67459138
97Amyotrophic lateral sclerosis (HP:0007354)1.65766154
98Abnormality of homocysteine metabolism (HP:0010919)1.64484238
99Homocystinuria (HP:0002156)1.64484238
100Mucopolysacchariduria (HP:0008155)1.63923137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM24.31605648
2DYRK1B3.86266705
3WNK43.80017829
4BMPR1B3.76838870
5PINK13.25388768
6SIK12.89259226
7NTRK32.79963046
8BCR2.75524421
9EPHB12.48259125
10CDK82.40153168
11FGFR42.10341132
12TAOK31.94492647
13MAP2K61.87752179
14WNK11.81871051
15CDK61.79365216
16CDK91.71884675
17SIK21.66244926
18MAP3K51.57048200
19MARK21.48828286
20MAP3K61.46881612
21CHUK1.46147472
22TNK21.43286347
23ERBB21.34869210
24PKN21.33333243
25STK391.31733930
26FGFR31.29973314
27MST1R1.29915093
28SIK31.29663073
29TGFBR11.28561932
30PTK61.20092892
31EPHA31.19436085
32TBK11.18425739
33CSNK1A1L1.18074250
34TRIB31.09559587
35TYRO31.07776790
36NME11.07524284
37ICK1.07338296
38KDR1.04327935
39EPHA21.01599511
40FGFR21.00707495
41ERBB31.00453399
42PDGFRB0.97796139
43MAP3K70.96939708
44EIF2AK30.94357521
45CDK120.93030346
46CAMK2B0.90028890
47CSNK1G30.89444592
48MUSK0.85033036
49MAP2K40.84400700
50CDK70.75190117
51PIK3CA0.74626514
52CAMK2D0.65570329
53EPHA40.65250683
54RIPK40.64189775
55PRKAA10.62497630
56BRD40.62155119
57MAP2K70.61707194
58PTK2B0.60787115
59CSNK1G10.59960829
60TYK20.58905022
61MTOR0.57318356
62FGFR10.57189563
63MINK10.57044630
64UHMK10.56295434
65BMX0.56176341
66WNK30.55240546
67MET0.54737673
68CDK30.54700511
69PRKD30.52210231
70CSNK1D0.51642464
71MAP3K40.51641369
72JAK10.50140386
73CSNK1G20.49840699
74PRKG20.48983237
75PRKD10.48472042
76DAPK30.48330343
77RPS6KL10.46502043
78RPS6KC10.46502043
79ITK0.45468058
80PRKD20.45066718
81ABL10.44130397
82TRIM280.43165061
83RPS6KA60.41939249
84RET0.41704570
85MAPKAPK30.41500233
86TEC0.41330180
87RPS6KA20.40944356
88MAP2K30.38641593
89MAP4K10.37867050
90TSSK60.37849810
91PDGFRA0.35687149
92MAPK70.35635490
93PRKAA20.35238978
94MAPKAPK20.34867131
95MAPK80.34587808
96MAPK10.32602704
97MAPK140.31737022
98RIPK10.31680309
99PDPK10.31663479
100HIPK20.29797222

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.01402380
2Circadian rhythm_Homo sapiens_hsa047103.93252849
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.46776961
4Sulfur relay system_Homo sapiens_hsa041223.06092448
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.87005713
6Notch signaling pathway_Homo sapiens_hsa043302.83810439
7Selenocompound metabolism_Homo sapiens_hsa004502.35410455
8Other glycan degradation_Homo sapiens_hsa005112.23640474
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.14144033
10Glycerophospholipid metabolism_Homo sapiens_hsa005642.08404047
11Basal transcription factors_Homo sapiens_hsa030222.03004815
12Complement and coagulation cascades_Homo sapiens_hsa046102.01640852
13Regulation of autophagy_Homo sapiens_hsa041401.83603621
14ABC transporters_Homo sapiens_hsa020101.79482333
15Lysine degradation_Homo sapiens_hsa003101.67534697
16Axon guidance_Homo sapiens_hsa043601.66499883
17One carbon pool by folate_Homo sapiens_hsa006701.65017905
18Longevity regulating pathway - mammal_Homo sapiens_hsa042111.59148426
19Steroid biosynthesis_Homo sapiens_hsa001001.51975997
20VEGF signaling pathway_Homo sapiens_hsa043701.45843187
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40771008
22Fanconi anemia pathway_Homo sapiens_hsa034601.32494979
23AMPK signaling pathway_Homo sapiens_hsa041521.31972429
24Insulin resistance_Homo sapiens_hsa049311.30577069
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22115938
26Ether lipid metabolism_Homo sapiens_hsa005651.21309794
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17849630
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.17387871
29Phototransduction_Homo sapiens_hsa047441.15597623
30Glucagon signaling pathway_Homo sapiens_hsa049221.15303727
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13943463
32Vitamin B6 metabolism_Homo sapiens_hsa007501.12931175
33N-Glycan biosynthesis_Homo sapiens_hsa005101.12165029
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12032666
35Linoleic acid metabolism_Homo sapiens_hsa005911.09108037
36ErbB signaling pathway_Homo sapiens_hsa040121.06349126
37Fat digestion and absorption_Homo sapiens_hsa049750.97203683
38Caffeine metabolism_Homo sapiens_hsa002320.94150923
39Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90224940
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87046706
41Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86197013
42Adipocytokine signaling pathway_Homo sapiens_hsa049200.86106080
43TGF-beta signaling pathway_Homo sapiens_hsa043500.85460182
44Glycerolipid metabolism_Homo sapiens_hsa005610.85135334
45Chronic myeloid leukemia_Homo sapiens_hsa052200.84232197
46Ras signaling pathway_Homo sapiens_hsa040140.83076782
47Insulin signaling pathway_Homo sapiens_hsa049100.82546440
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80801947
49RNA degradation_Homo sapiens_hsa030180.79817905
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79204701
51Choline metabolism in cancer_Homo sapiens_hsa052310.79090004
52mTOR signaling pathway_Homo sapiens_hsa041500.75413965
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75284345
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74791074
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74677170
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74544139
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74257937
58Vibrio cholerae infection_Homo sapiens_hsa051100.73778261
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71864110
60mRNA surveillance pathway_Homo sapiens_hsa030150.69039156
61Hepatitis B_Homo sapiens_hsa051610.67950527
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64923563
63Estrogen signaling pathway_Homo sapiens_hsa049150.62954437
64Oxytocin signaling pathway_Homo sapiens_hsa049210.56621330
65Fatty acid biosynthesis_Homo sapiens_hsa000610.56489644
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55792949
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54911733
68p53 signaling pathway_Homo sapiens_hsa041150.53894179
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53327728
70Viral carcinogenesis_Homo sapiens_hsa052030.53173849
71Endocytosis_Homo sapiens_hsa041440.52734723
72Hippo signaling pathway_Homo sapiens_hsa043900.51504117
73MAPK signaling pathway_Homo sapiens_hsa040100.50449685
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48945209
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47577645
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45070326
77Biosynthesis of amino acids_Homo sapiens_hsa012300.44467959
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.44108915
79Glioma_Homo sapiens_hsa052140.43699683
80Ovarian steroidogenesis_Homo sapiens_hsa049130.40932208
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40907208
82Nicotine addiction_Homo sapiens_hsa050330.40531868
83FoxO signaling pathway_Homo sapiens_hsa040680.39781925
84Rap1 signaling pathway_Homo sapiens_hsa040150.39164913
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38014943
86Epstein-Barr virus infection_Homo sapiens_hsa051690.35626227
87Fatty acid metabolism_Homo sapiens_hsa012120.35518387
88GnRH signaling pathway_Homo sapiens_hsa049120.34006083
89Cholinergic synapse_Homo sapiens_hsa047250.33180797
90Prostate cancer_Homo sapiens_hsa052150.33077475
91GABAergic synapse_Homo sapiens_hsa047270.30772399
92Thyroid hormone synthesis_Homo sapiens_hsa049180.30281080
93Dorso-ventral axis formation_Homo sapiens_hsa043200.29186122
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28734008
95Starch and sucrose metabolism_Homo sapiens_hsa005000.28572876
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.28467010
97Arginine and proline metabolism_Homo sapiens_hsa003300.27932573
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26843058
99Wnt signaling pathway_Homo sapiens_hsa043100.25978558
100ECM-receptor interaction_Homo sapiens_hsa045120.24798655

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