RHOT1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1segment specification (GO:0007379)7.09062567
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.71429122
3acrosome reaction (GO:0007340)6.62316831
4cilium or flagellum-dependent cell motility (GO:0001539)6.12937348
5maternal behavior (GO:0042711)5.71695018
6epithelial cilium movement (GO:0003351)5.70220543
7positive regulation of mitotic sister chromatid separation (GO:1901970)5.37191084
8positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.37191084
9positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.37191084
10parental behavior (GO:0060746)5.05271753
11retrograde transport, vesicle recycling within Golgi (GO:0000301)4.96771145
12multicellular organismal movement (GO:0050879)4.95508304
13musculoskeletal movement (GO:0050881)4.95508304
14protein targeting to Golgi (GO:0000042)4.94867447
15cilium movement (GO:0003341)4.90321055
16establishment of protein localization to Golgi (GO:0072600)4.82898613
17seminiferous tubule development (GO:0072520)4.48047202
18mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.46237749
19positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.46237749
20regulation of pigment cell differentiation (GO:0050932)4.42641497
21protein localization to Golgi apparatus (GO:0034067)4.20777048
22establishment of mitochondrion localization (GO:0051654)4.07989593
23spinal cord motor neuron differentiation (GO:0021522)4.03003011
24mitochondrion transport along microtubule (GO:0047497)3.98400536
25establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.98400536
26DNA integration (GO:0015074)3.97341933
27neuron remodeling (GO:0016322)3.95914643
28axoneme assembly (GO:0035082)3.93711066
29protein polyglutamylation (GO:0018095)3.90949325
30RNA destabilization (GO:0050779)3.83226764
31axonemal dynein complex assembly (GO:0070286)3.81759197
32spermatid nucleus differentiation (GO:0007289)3.70168832
33Sertoli cell development (GO:0060009)3.69347539
34ubiquinone metabolic process (GO:0006743)3.63407330
35binding of sperm to zona pellucida (GO:0007339)3.58531034
36developmental pigmentation (GO:0048066)3.58352459
37multicellular organism reproduction (GO:0032504)3.54913069
38sperm-egg recognition (GO:0035036)3.54596589
39cytoplasmic mRNA processing body assembly (GO:0033962)3.46251879
40regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.43514832
41sperm motility (GO:0030317)3.41511575
42startle response (GO:0001964)3.41437987
43calcium ion-dependent exocytosis (GO:0017156)3.35015405
44behavioral response to nicotine (GO:0035095)3.29695648
45positive regulation of mitochondrial membrane permeability (GO:0035794)3.28365521
46regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.28170000
47neurotransmitter-gated ion channel clustering (GO:0072578)3.20310928
48regulation of male gonad development (GO:2000018)3.16321184
49water-soluble vitamin biosynthetic process (GO:0042364)3.14622645
50positive regulation of skeletal muscle tissue development (GO:0048643)3.10325356
51cilium assembly (GO:0042384)3.07955328
52neuron fate determination (GO:0048664)3.06620448
53proximal/distal pattern formation (GO:0009954)3.04127042
54intraciliary transport (GO:0042073)3.03709314
55phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.00912529
56forebrain neuron differentiation (GO:0021879)3.00157050
57cilium organization (GO:0044782)2.99822887
58G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.99728715
59microtubule depolymerization (GO:0007019)2.99255975
60coenzyme A metabolic process (GO:0015936)2.98223400
61cell-cell recognition (GO:0009988)2.97815331
62regulation of hexokinase activity (GO:1903299)2.94640059
63regulation of glucokinase activity (GO:0033131)2.94640059
64positive regulation of macroautophagy (GO:0016239)2.92501128
65cell differentiation in spinal cord (GO:0021515)2.91030849
66behavioral response to ethanol (GO:0048149)2.89871248
67DNA double-strand break processing (GO:0000729)2.89817385
68microtubule severing (GO:0051013)2.89815895
69positive regulation of male gonad development (GO:2000020)2.88934026
70olfactory bulb development (GO:0021772)2.88635354
71somite development (GO:0061053)2.85346475
72motile cilium assembly (GO:0044458)2.84371552
73response to pheromone (GO:0019236)2.80036828
74glucocorticoid biosynthetic process (GO:0006704)2.79555528
75cilium morphogenesis (GO:0060271)2.77557776
76regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77466348
77neuron cell-cell adhesion (GO:0007158)2.74946134
78histone H3-K9 methylation (GO:0051567)2.74722740
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74131732
80resolution of meiotic recombination intermediates (GO:0000712)2.74035818
81phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.70495064
82neural tube formation (GO:0001841)2.69403305
83regulation of developmental pigmentation (GO:0048070)2.67651240
84protein K48-linked ubiquitination (GO:0070936)2.65045689
85inner ear receptor stereocilium organization (GO:0060122)2.63229017
86synaptic vesicle docking involved in exocytosis (GO:0016081)2.62306954
87mRNA splice site selection (GO:0006376)2.61852003
88negative regulation of glial cell proliferation (GO:0060253)2.61070136
89positive regulation of neurological system process (GO:0031646)2.60780012
90regulation of cilium movement (GO:0003352)2.60658711
91multicellular organismal reproductive behavior (GO:0033057)2.60139090
92intra-Golgi vesicle-mediated transport (GO:0006891)2.58468724
93male sex determination (GO:0030238)2.57648109
94spermatid development (GO:0007286)2.57219797
95pyrimidine nucleobase catabolic process (GO:0006208)2.57178757
96insulin-like growth factor receptor signaling pathway (GO:0048009)2.55427799
97quinone metabolic process (GO:1901661)2.55260517
98calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.54956702
99mitotic G1 DNA damage checkpoint (GO:0031571)2.51622980
100pattern specification involved in kidney development (GO:0061004)11.5171439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.06418077
2IGF1R_20145208_ChIP-Seq_DFB_Human3.73743846
3VDR_22108803_ChIP-Seq_LS180_Human3.31161438
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.28116999
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.21728384
6POU3F2_20337985_ChIP-ChIP_501MEL_Human3.02015959
7GBX2_23144817_ChIP-Seq_PC3_Human2.93215378
8EZH2_22144423_ChIP-Seq_EOC_Human2.90814993
9FUS_26573619_Chip-Seq_HEK293_Human2.72035065
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.68851494
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.60830466
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55542815
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48555291
14IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.28838858
15CBP_20019798_ChIP-Seq_JUKART_Human2.28838858
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.13597786
17ER_23166858_ChIP-Seq_MCF-7_Human2.13430023
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12461890
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.08587346
20TAF15_26573619_Chip-Seq_HEK293_Human2.05652259
21EWS_26573619_Chip-Seq_HEK293_Human2.01437157
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.99630740
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99630740
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.95332069
25P300_19829295_ChIP-Seq_ESCs_Human1.88451267
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81722179
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78755089
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78014991
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.75820210
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74004758
31KLF5_20875108_ChIP-Seq_MESCs_Mouse1.65223841
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63620189
33SMAD4_21799915_ChIP-Seq_A2780_Human1.63479030
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59672105
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58139866
36BCAT_22108803_ChIP-Seq_LS180_Human1.53320182
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52011850
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50659442
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46300588
40STAT3_23295773_ChIP-Seq_U87_Human1.46216268
41AR_25329375_ChIP-Seq_VCAP_Human1.43445130
42FLI1_21867929_ChIP-Seq_TH2_Mouse1.43072879
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40310261
44TCF4_23295773_ChIP-Seq_U87_Human1.33640741
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31480852
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.30064289
47RUNX2_22187159_ChIP-Seq_PCA_Human1.29890890
48KDM2B_26808549_Chip-Seq_REH_Human1.29297064
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28450016
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28279727
51TCF4_22108803_ChIP-Seq_LS180_Human1.28211369
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25991440
53TP53_22573176_ChIP-Seq_HFKS_Human1.25832589
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25526998
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25367998
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24499767
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23616582
58CDX2_22108803_ChIP-Seq_LS180_Human1.22751992
59TP53_18474530_ChIP-ChIP_U2OS_Human1.21086078
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.20197284
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19868546
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.18858031
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18780877
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18557415
65SOX2_19829295_ChIP-Seq_ESCs_Human1.17681997
66NANOG_19829295_ChIP-Seq_ESCs_Human1.17681997
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.17334195
68WDR5_24793694_ChIP-Seq_LNCAP_Human1.16942154
69TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16245556
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.16157901
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.15341982
72RNF2_27304074_Chip-Seq_NSC_Mouse1.13648523
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12500858
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.11351337
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09204442
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09180287
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.06713579
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06235323
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.05214750
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04113604
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03713855
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03514227
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02954609
84P53_22387025_ChIP-Seq_ESCs_Mouse1.01692753
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00387482
86JUN_21703547_ChIP-Seq_K562_Human1.00203016
87CRX_20693478_ChIP-Seq_RETINA_Mouse0.98017194
88NCOR_22424771_ChIP-Seq_293T_Human0.97318988
89AR_21572438_ChIP-Seq_LNCaP_Human0.97068497
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95832797
91IRF1_19129219_ChIP-ChIP_H3396_Human0.95788940
92EZH2_27304074_Chip-Seq_ESCs_Mouse0.95613168
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.95252621
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95252621
95PHF8_20622853_ChIP-Seq_HELA_Human0.94378388
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94351228
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94166629
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.93743569
99CMYC_18555785_Chip-Seq_ESCs_Mouse0.92210390
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.91113429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation5.39855664
2MP0009379_abnormal_foot_pigmentation5.09004264
3MP0003787_abnormal_imprinting4.15200316
4MP0005409_darkened_coat_color3.90064331
5MP0004133_heterotaxia3.32977370
6MP0003880_abnormal_central_pattern2.85704263
7MP0001529_abnormal_vocalization2.76068850
8MP0002102_abnormal_ear_morphology2.62793732
9MP0005248_abnormal_Harderian_gland2.57591386
10MP0005410_abnormal_fertilization2.40426767
11MP0005174_abnormal_tail_pigmentation2.37306005
12MP0002653_abnormal_ependyma_morphology2.36266761
13MP0003122_maternal_imprinting2.20599901
14MP0003121_genomic_imprinting2.12732554
15MP0000015_abnormal_ear_pigmentation1.99189129
16MP0000778_abnormal_nervous_system1.95323657
17MP0002234_abnormal_pharynx_morphology1.95191099
18MP0002638_abnormal_pupillary_reflex1.93369594
19MP0002009_preneoplasia1.89828539
20MP0002138_abnormal_hepatobiliary_system1.76277705
21MP0003136_yellow_coat_color1.75121131
22MP0000383_abnormal_hair_follicle1.75017119
23MP0006072_abnormal_retinal_apoptosis1.74806467
24MP0001486_abnormal_startle_reflex1.71183991
25MP0000631_abnormal_neuroendocrine_gland1.67016882
26MP0005187_abnormal_penis_morphology1.61387551
27MP0001299_abnormal_eye_distance/1.54699632
28MP0001968_abnormal_touch/_nociception1.45897352
29MP0000647_abnormal_sebaceous_gland1.39687489
30MP0003698_abnormal_male_reproductive1.33043240
31MP0010678_abnormal_skin_adnexa1.32718716
32MP0000049_abnormal_middle_ear1.32373544
33MP0005253_abnormal_eye_physiology1.31498659
34MP0000516_abnormal_urinary_system1.31210512
35MP0005367_renal/urinary_system_phenotyp1.31210512
36MP0002876_abnormal_thyroid_physiology1.29799721
37MP0005379_endocrine/exocrine_gland_phen1.27181534
38MP0009046_muscle_twitch1.26908676
39MP0008877_abnormal_DNA_methylation1.25044991
40MP0009745_abnormal_behavioral_response1.24845421
41MP0002095_abnormal_skin_pigmentation1.24181562
42MP0005645_abnormal_hypothalamus_physiol1.19483188
43MP0002272_abnormal_nervous_system1.16546634
44MP0001929_abnormal_gametogenesis1.16351723
45MP0006276_abnormal_autonomic_nervous1.14350009
46MP0005386_behavior/neurological_phenoty1.14035996
47MP0004924_abnormal_behavior1.14035996
48MP0002557_abnormal_social/conspecific_i1.13953572
49MP0002837_dystrophic_cardiac_calcinosis1.13823546
50MP0000026_abnormal_inner_ear1.13128431
51MP0002928_abnormal_bile_duct1.09667677
52MP0003632_abnormal_nervous_system1.06939877
53MP0001984_abnormal_olfaction1.05177088
54MP0005551_abnormal_eye_electrophysiolog1.04521918
55MP0006292_abnormal_olfactory_placode1.01329010
56MP0001764_abnormal_homeostasis1.01100070
57MP0002184_abnormal_innervation0.99322968
58MP0003385_abnormal_body_wall0.98083581
59MP0001986_abnormal_taste_sensitivity0.95049298
60MP0000955_abnormal_spinal_cord0.94590181
61MP0004147_increased_porphyrin_level0.94524445
62MP0002177_abnormal_outer_ear0.94225714
63MP0004885_abnormal_endolymph0.94152528
64MP0002160_abnormal_reproductive_system0.94060094
65MP0008057_abnormal_DNA_replication0.93778168
66MP0003646_muscle_fatigue0.92129028
67MP0009780_abnormal_chondrocyte_physiolo0.91041073
68MP0000653_abnormal_sex_gland0.85882574
69MP0003937_abnormal_limbs/digits/tail_de0.85282226
70MP0003941_abnormal_skin_development0.84889619
71MP0003879_abnormal_hair_cell0.84596562
72MP0002210_abnormal_sex_determination0.84433932
73MP0002751_abnormal_autonomic_nervous0.83917211
74MP0002752_abnormal_somatic_nervous0.82659599
75MP0003183_abnormal_peptide_metabolism0.78750179
76MP0002127_abnormal_cardiovascular_syste0.78695575
77MP0002572_abnormal_emotion/affect_behav0.78552726
78MP0002938_white_spotting0.77004670
79MP0008007_abnormal_cellular_replicative0.75667271
80MP0002064_seizures0.75306598
81MP0002084_abnormal_developmental_patter0.75209696
82MP0000013_abnormal_adipose_tissue0.73281530
83MP0001970_abnormal_pain_threshold0.72571479
84MP0001145_abnormal_male_reproductive0.72274023
85MP0002229_neurodegeneration0.70331652
86MP0005195_abnormal_posterior_eye0.69648781
87MP0002882_abnormal_neuron_morphology0.69195646
88MP0004270_analgesia0.69170631
89MP0003755_abnormal_palate_morphology0.66847717
90MP0003119_abnormal_digestive_system0.66708864
91MP0001485_abnormal_pinna_reflex0.66651943
92MP0004859_abnormal_synaptic_plasticity0.66528410
93MP0002282_abnormal_trachea_morphology0.66478350
94MP0002909_abnormal_adrenal_gland0.66370491
95MP0003635_abnormal_synaptic_transmissio0.65733480
96MP0003283_abnormal_digestive_organ0.65408849
97MP0002736_abnormal_nociception_after0.64917969
98MP0002067_abnormal_sensory_capabilities0.64116786
99MP0002161_abnormal_fertility/fecundity0.62921173
100MP0001286_abnormal_eye_development0.62422727

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.71513280
2True hermaphroditism (HP:0010459)4.53391021
3Resting tremor (HP:0002322)4.18666721
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.15243946
5Pancreatic cysts (HP:0001737)4.09226745
6Chronic hepatic failure (HP:0100626)4.06893244
7Hepatoblastoma (HP:0002884)3.96706287
8Facial hemangioma (HP:0000329)3.74982123
9Nephronophthisis (HP:0000090)3.66553040
10Metaphyseal dysplasia (HP:0100255)3.53395017
11Abnormal respiratory motile cilium physiology (HP:0012261)3.49998572
12Median cleft lip (HP:0000161)3.48902446
13Choroideremia (HP:0001139)3.32709246
14Abnormal respiratory epithelium morphology (HP:0012253)3.27317237
15Abnormal respiratory motile cilium morphology (HP:0005938)3.27317237
16Pancreatic fibrosis (HP:0100732)3.26875815
17Molar tooth sign on MRI (HP:0002419)3.18277206
18Abnormality of midbrain morphology (HP:0002418)3.18277206
19Neonatal respiratory distress (HP:0002643)3.06358678
20Abnormal biliary tract physiology (HP:0012439)2.98012284
21Bile duct proliferation (HP:0001408)2.98012284
22Abnormality of the renal medulla (HP:0100957)2.94065001
23Astrocytoma (HP:0009592)2.93850976
24Abnormality of the astrocytes (HP:0100707)2.93850976
25Ependymoma (HP:0002888)2.88088548
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.82577892
27Absent/shortened dynein arms (HP:0200106)2.82577892
28Intestinal atresia (HP:0011100)2.73609959
29Buphthalmos (HP:0000557)2.71668562
30Rhinitis (HP:0012384)2.61985501
31Abnormal ciliary motility (HP:0012262)2.60614559
32Medulloblastoma (HP:0002885)2.57993748
33Abnormality of the costochondral junction (HP:0000919)2.52554458
34Methylmalonic acidemia (HP:0002912)2.51135839
35Bony spicule pigmentary retinopathy (HP:0007737)2.50471600
36Double outlet right ventricle (HP:0001719)2.50102196
37Congenital malformation of the right heart (HP:0011723)2.50102196
38Hypochromic microcytic anemia (HP:0004840)2.45588528
39Chronic bronchitis (HP:0004469)2.44026446
40Attenuation of retinal blood vessels (HP:0007843)2.43564162
41Volvulus (HP:0002580)2.40534410
42Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.39938700
43Tubular atrophy (HP:0000092)2.35784291
44Abnormality of the frontal sinuses (HP:0002687)2.33173269
45Neoplasm of the heart (HP:0100544)2.32917897
46Occipital encephalocele (HP:0002085)2.30442333
47Abnormal hemoglobin (HP:0011902)2.29081107
48Abnormal sex determination (HP:0012244)2.28331345
49Sex reversal (HP:0012245)2.28331345
50Colon cancer (HP:0003003)2.27209940
51Abnormality of macular pigmentation (HP:0008002)2.27067101
52Cystic liver disease (HP:0006706)2.25735198
53Hamartoma of the eye (HP:0010568)2.25430948
54Dialeptic seizures (HP:0011146)2.22499667
55Failure to thrive in infancy (HP:0001531)2.21897302
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21443234
57Drooling (HP:0002307)2.21294801
58Abnormality of homocysteine metabolism (HP:0010919)2.20728995
59Homocystinuria (HP:0002156)2.20728995
60Stomach cancer (HP:0012126)2.18938551
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18624416
62Male pseudohermaphroditism (HP:0000037)2.17340106
63Late onset (HP:0003584)2.15796902
64Oligodactyly (hands) (HP:0001180)2.14235559
65Abnormal rod and cone electroretinograms (HP:0008323)2.11716596
66Lower limb asymmetry (HP:0100559)2.10558689
67Shawl scrotum (HP:0000049)2.10496123
68Atonic seizures (HP:0010819)2.09915614
69Neoplasm of striated muscle (HP:0009728)2.08841827
70Gonadal dysgenesis (HP:0000133)2.06831461
71Congenital hepatic fibrosis (HP:0002612)2.06109887
72Abolished electroretinogram (ERG) (HP:0000550)2.05680438
73Cortical dysplasia (HP:0002539)2.04808083
74Hypoplastic ischia (HP:0003175)2.04231917
75Congenital sensorineural hearing impairment (HP:0008527)2.03346817
76Exocrine pancreatic insufficiency (HP:0001738)2.03182828
77Tented upper lip vermilion (HP:0010804)2.01641274
78Excessive salivation (HP:0003781)2.00694121
79Abnormality of methionine metabolism (HP:0010901)1.98597312
80Glioma (HP:0009733)1.98203568
81Abnormality of the pancreatic islet cells (HP:0006476)1.95606386
82Abnormality of endocrine pancreas physiology (HP:0012093)1.95606386
83Furrowed tongue (HP:0000221)1.94797609
84Postaxial foot polydactyly (HP:0001830)1.93060430
85Absent frontal sinuses (HP:0002688)1.89572693
86Hypoglycemic seizures (HP:0002173)1.88216117
87Genetic anticipation (HP:0003743)1.87828977
88Postural instability (HP:0002172)1.87787328
89Heterochromia iridis (HP:0001100)1.87377983
90Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.85483066
91Limb hypertonia (HP:0002509)1.84306716
92Epidermoid cyst (HP:0200040)1.83962191
93Abnormal drinking behavior (HP:0030082)1.83080829
94Polydipsia (HP:0001959)1.83080829
95Decreased central vision (HP:0007663)1.83020229
96Stage 5 chronic kidney disease (HP:0003774)1.80783768
97Abnormality of the renal cortex (HP:0011035)1.79121509
98Medial flaring of the eyebrow (HP:0010747)1.78802597
99Abnormality of the antihelix (HP:0009738)1.77392009
100Postaxial hand polydactyly (HP:0001162)1.77082643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.88688413
2FRK3.77914912
3PIM23.45600092
4MAP3K43.24730704
5BMPR1B2.90493759
6DYRK32.69478981
7TRIM282.63278815
8ERBB32.54276411
9MAP2K72.50929868
10DYRK1B2.33263529
11MAP4K22.10449086
12CDC72.08086518
13PIK3CG1.97059863
14TAOK31.90742048
15PDK21.84911454
16WNK31.74583576
17BRD41.73767570
18CDK191.73129741
19BCR1.71467492
20NUAK11.69124388
21EPHA41.65448372
22MAPK131.61656497
23INSRR1.59816323
24CAMKK21.54613811
25NTRK31.54047882
26CSNK1G31.53529820
27ADRBK21.51985972
28CSNK1G11.42333505
29CSNK1G21.39936030
30PLK41.32409004
31PLK21.32084745
32LATS11.29200954
33CDK81.27146078
34MKNK11.26364186
35CSNK1A1L1.25541402
36AKT31.19928503
37TGFBR11.15590147
38MKNK21.15302173
39CAMK2B1.13047594
40EIF2AK31.11674312
41DAPK21.08952179
42NEK61.08059076
43STK391.07942562
44RPS6KA40.95627505
45FER0.91761268
46MAPK70.91196666
47FGFR30.90452540
48DYRK1A0.85045148
49MAP2K40.84350985
50CAMK2D0.82650039
51UHMK10.77602880
52CDK90.76082667
53MAP3K50.74006186
54MST1R0.69471800
55CAMK2A0.69185010
56MAP3K60.67789097
57DDR20.66815287
58CDK60.66493370
59IRAK10.65196935
60PAK60.61781288
61WNK40.61376996
62PRKD30.59603801
63PIK3CA0.59129989
64PNCK0.59053485
65GRK10.58806097
66CAMK40.56791358
67DAPK30.55418328
68CAMK2G0.54944892
69PRKCE0.54501058
70MARK10.51056340
71MATK0.50566079
72BRSK20.48334540
73STK38L0.45509732
74CSNK1A10.42787948
75FGFR20.39914591
76CASK0.39237368
77PTK2B0.38697966
78CHUK0.36755059
79PRKACA0.36305888
80PKN10.33723484
81ROCK10.33156998
82PRKG10.32695533
83PTK60.32155415
84SGK2230.31932225
85SGK4940.31932225
86ABL20.31108006
87OXSR10.30446200
88IRAK40.29732860
89SGK20.29522917
90INSR0.28617955
91CAMKK10.28440451
92PRKCI0.28256358
93MAP3K90.27886717
94MAPK10.27115530
95MAP2K60.26097003
96CDK30.23912684
97ERBB20.23788623
98ATR0.23367583
99RPS6KA60.22976079
100GSK3A0.21833624

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.93710986
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.19937407
3Vitamin B6 metabolism_Homo sapiens_hsa007502.90896172
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.65783866
5Basal transcription factors_Homo sapiens_hsa030222.44342216
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.31463717
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21692608
8Phototransduction_Homo sapiens_hsa047442.19251823
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09247403
10Circadian rhythm_Homo sapiens_hsa047102.04645893
11Butanoate metabolism_Homo sapiens_hsa006501.96234037
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88331526
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.72178028
14Olfactory transduction_Homo sapiens_hsa047401.71219782
15Taste transduction_Homo sapiens_hsa047421.68624738
16Insulin secretion_Homo sapiens_hsa049111.63955232
17Circadian entrainment_Homo sapiens_hsa047131.62401752
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50404274
19beta-Alanine metabolism_Homo sapiens_hsa004101.45605033
20GABAergic synapse_Homo sapiens_hsa047271.42265572
21Nicotine addiction_Homo sapiens_hsa050331.41384873
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39792069
23Regulation of autophagy_Homo sapiens_hsa041401.39493140
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36666536
25Renin secretion_Homo sapiens_hsa049241.35016731
26Synaptic vesicle cycle_Homo sapiens_hsa047211.29073126
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29042103
28Propanoate metabolism_Homo sapiens_hsa006401.24453247
29Dopaminergic synapse_Homo sapiens_hsa047281.21809040
30Hedgehog signaling pathway_Homo sapiens_hsa043401.21753282
31Basal cell carcinoma_Homo sapiens_hsa052171.20127469
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.18635500
33Tryptophan metabolism_Homo sapiens_hsa003801.16779088
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16589883
35Type II diabetes mellitus_Homo sapiens_hsa049301.11792182
36Linoleic acid metabolism_Homo sapiens_hsa005911.11786327
37Selenocompound metabolism_Homo sapiens_hsa004501.11491831
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09876637
39Cholinergic synapse_Homo sapiens_hsa047251.09262400
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09083559
41Collecting duct acid secretion_Homo sapiens_hsa049661.08967784
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07321190
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06841763
44Salivary secretion_Homo sapiens_hsa049701.06246052
45Bile secretion_Homo sapiens_hsa049761.05654513
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93088713
47Long-term depression_Homo sapiens_hsa047300.84770286
48Fanconi anemia pathway_Homo sapiens_hsa034600.82028618
49Serotonergic synapse_Homo sapiens_hsa047260.80482775
50Morphine addiction_Homo sapiens_hsa050320.79953387
51AMPK signaling pathway_Homo sapiens_hsa041520.79673493
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76342344
53Nitrogen metabolism_Homo sapiens_hsa009100.76177637
54Peroxisome_Homo sapiens_hsa041460.74948441
55mTOR signaling pathway_Homo sapiens_hsa041500.74861909
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74138760
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73679576
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73140172
59Amphetamine addiction_Homo sapiens_hsa050310.72609993
60Glutamatergic synapse_Homo sapiens_hsa047240.72011580
61ABC transporters_Homo sapiens_hsa020100.70078002
62RNA degradation_Homo sapiens_hsa030180.69073912
63Inositol phosphate metabolism_Homo sapiens_hsa005620.68412854
64Oxidative phosphorylation_Homo sapiens_hsa001900.66910390
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66396183
66Glucagon signaling pathway_Homo sapiens_hsa049220.65555706
67Ether lipid metabolism_Homo sapiens_hsa005650.64224396
68Fatty acid elongation_Homo sapiens_hsa000620.62655022
69Glycerolipid metabolism_Homo sapiens_hsa005610.62519627
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62099834
71Alcoholism_Homo sapiens_hsa050340.56405948
72Estrogen signaling pathway_Homo sapiens_hsa049150.56297634
73Melanoma_Homo sapiens_hsa052180.55352339
74Melanogenesis_Homo sapiens_hsa049160.53935208
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.53159812
76Oxytocin signaling pathway_Homo sapiens_hsa049210.52393520
77ErbB signaling pathway_Homo sapiens_hsa040120.52000666
78RNA transport_Homo sapiens_hsa030130.51294307
79Calcium signaling pathway_Homo sapiens_hsa040200.47419320
80Thyroid hormone synthesis_Homo sapiens_hsa049180.47174481
81Chemical carcinogenesis_Homo sapiens_hsa052040.46873296
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46305120
83TGF-beta signaling pathway_Homo sapiens_hsa043500.45244541
84Gastric acid secretion_Homo sapiens_hsa049710.45135447
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45040200
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44732343
87Fatty acid degradation_Homo sapiens_hsa000710.44270660
88Cocaine addiction_Homo sapiens_hsa050300.43160375
89Huntingtons disease_Homo sapiens_hsa050160.42779140
90Non-homologous end-joining_Homo sapiens_hsa034500.41388517
91cAMP signaling pathway_Homo sapiens_hsa040240.40953433
92Hippo signaling pathway_Homo sapiens_hsa043900.39442475
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39303311
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37963923
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37937156
96Axon guidance_Homo sapiens_hsa043600.37634268
97p53 signaling pathway_Homo sapiens_hsa041150.37463072
98Caffeine metabolism_Homo sapiens_hsa002320.36068272
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35120885
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33310569

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