RHOT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.75128104
2sarcomere organization (GO:0045214)5.62599882
3negative regulation of erythrocyte differentiation (GO:0045647)5.59123533
4mannose metabolic process (GO:0006013)5.47650255
5cardiac myofibril assembly (GO:0055003)5.39941198
6negative regulation of potassium ion transmembrane transport (GO:1901380)5.23303702
7myofibril assembly (GO:0030239)4.82975687
8tricarboxylic acid cycle (GO:0006099)4.79196526
9carnitine shuttle (GO:0006853)4.69010321
10cardiac muscle contraction (GO:0060048)4.58500060
11aspartate family amino acid catabolic process (GO:0009068)4.43560292
12lysine catabolic process (GO:0006554)4.41525654
13lysine metabolic process (GO:0006553)4.41525654
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.39373959
15regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.30528895
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.29921215
17negative regulation of cell size (GO:0045792)4.29089976
182-oxoglutarate metabolic process (GO:0006103)4.26819352
19ventricular cardiac muscle cell action potential (GO:0086005)4.21770075
20regulation of actin filament-based movement (GO:1903115)4.21654129
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.16887912
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.16779729
23fatty acid transmembrane transport (GO:1902001)4.15826969
24creatine metabolic process (GO:0006600)4.13859080
25apoptotic process involved in morphogenesis (GO:0060561)4.12223355
26plasma membrane repair (GO:0001778)3.99018542
27actin-myosin filament sliding (GO:0033275)3.96423187
28muscle filament sliding (GO:0030049)3.96423187
29cell communication involved in cardiac conduction (GO:0086065)3.94005727
30regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.91918019
31positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.90131245
32adult heart development (GO:0007512)3.86258349
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.84070549
34NADH metabolic process (GO:0006734)3.81781246
35bundle of His cell to Purkinje myocyte communication (GO:0086069)3.74282056
36actomyosin structure organization (GO:0031032)3.69284032
37cardiac muscle cell development (GO:0055013)3.69240453
38thymic T cell selection (GO:0045061)3.64858457
39carnitine transmembrane transport (GO:1902603)3.62425877
40regulation of skeletal muscle contraction (GO:0014819)3.61938047
41striated muscle contraction (GO:0006941)3.60438835
42carnitine transport (GO:0015879)3.60198767
43amino-acid betaine transport (GO:0015838)3.60198767
44cell communication by electrical coupling (GO:0010644)3.56600322
45histone H4 deacetylation (GO:0070933)3.55736271
46regulation of membrane repolarization (GO:0060306)3.55353503
47regulation of acyl-CoA biosynthetic process (GO:0050812)3.53934288
48fatty acid beta-oxidation (GO:0006635)3.53784695
49short-chain fatty acid metabolic process (GO:0046459)3.49426424
50regulation of ARF GTPase activity (GO:0032312)3.48338751
51cardiac cell development (GO:0055006)3.45178203
52regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.44728948
53cardiac muscle hypertrophy (GO:0003300)3.44234723
54heart trabecula formation (GO:0060347)3.42836843
55semaphorin-plexin signaling pathway (GO:0071526)3.41799071
56regulation of the force of heart contraction (GO:0002026)3.41037239
57NIK/NF-kappaB signaling (GO:0038061)3.40891304
58dicarboxylic acid biosynthetic process (GO:0043650)3.38065326
593-UTR-mediated mRNA stabilization (GO:0070935)3.36256298
60acetyl-CoA metabolic process (GO:0006084)3.34202083
61cardiac muscle tissue morphogenesis (GO:0055008)3.33362971
62positive thymic T cell selection (GO:0045059)3.32789705
63regulation of coenzyme metabolic process (GO:0051196)3.30048282
64regulation of cofactor metabolic process (GO:0051193)3.30048282
65response to muramyl dipeptide (GO:0032495)3.27503191
66ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.27171769
67regulation of mammary gland epithelial cell proliferation (GO:0033599)3.26813170
68negative regulation of cytosolic calcium ion concentration (GO:0051481)3.26663115
69striated muscle hypertrophy (GO:0014897)3.26639475
70proline biosynthetic process (GO:0006561)3.26024341
71regulation of fatty acid oxidation (GO:0046320)3.24974746
72sarcoplasmic reticulum calcium ion transport (GO:0070296)3.24725991
73actin-mediated cell contraction (GO:0070252)3.24130856
74modulation by virus of host process (GO:0019054)3.23674379
75regulation of striated muscle contraction (GO:0006942)3.23420346
76regulation of relaxation of muscle (GO:1901077)3.22556022
77oxaloacetate metabolic process (GO:0006107)3.22450398
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.21707577
79regulation of cardiac muscle cell contraction (GO:0086004)3.20341285
80tricarboxylic acid metabolic process (GO:0072350)3.19396100
81positive regulation of gamma-delta T cell activation (GO:0046645)3.17986714
82intracellular estrogen receptor signaling pathway (GO:0030520)3.17724738
83biotin metabolic process (GO:0006768)3.16362451
84antigen processing and presentation of endogenous antigen (GO:0019883)3.16355237
85positive regulation of Cdc42 GTPase activity (GO:0043089)3.15756323
86positive regulation of histone deacetylation (GO:0031065)3.15411096
87cellular ketone body metabolic process (GO:0046950)3.14836513
88histone H3 deacetylation (GO:0070932)3.14321158
89potassium ion import (GO:0010107)3.10736536
90fatty acid catabolic process (GO:0009062)3.10252476
91regulation of sequestering of triglyceride (GO:0010889)3.10223337
92regulation of cell communication by electrical coupling (GO:0010649)3.08720160
93activation of MAPKKK activity (GO:0000185)3.08126125
94fatty acid oxidation (GO:0019395)3.01966181
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.01877926
96regulation of type I interferon-mediated signaling pathway (GO:0060338)3.01809350
97activation of Rac GTPase activity (GO:0032863)3.01221690
98spliceosomal tri-snRNP complex assembly (GO:0000244)3.01059825
99COPI coating of Golgi vesicle (GO:0048205)3.00003689
100Golgi transport vesicle coating (GO:0048200)3.00003689
101muscle tissue morphogenesis (GO:0060415)2.99237550
102positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.98919841
103glyoxylate metabolic process (GO:0046487)2.98084333
104antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.97737830
105L-phenylalanine metabolic process (GO:0006558)2.96352839
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.96352839
107protein retention in ER lumen (GO:0006621)2.96236492
108modulation by symbiont of host cellular process (GO:0044068)2.95595687
109modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.95259480
110positive regulation by organism of defense response of other organism involved in symbiotic interact2.95259480
111modulation by symbiont of host immune response (GO:0052553)2.95259480
112positive regulation by symbiont of host defense response (GO:0052509)2.95259480
113modulation by symbiont of host defense response (GO:0052031)2.95259480
114modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.95259480
115succinate metabolic process (GO:0006105)2.95184068
116entrainment of circadian clock by photoperiod (GO:0043153)2.95002406
117quaternary ammonium group transport (GO:0015697)2.94698087
118lipid oxidation (GO:0034440)2.94480109
119cardiac muscle cell action potential involved in contraction (GO:0086002)2.94377276
120cardiac muscle cell action potential (GO:0086001)2.92695181
121adherens junction assembly (GO:0034333)2.92684173
122sodium ion export (GO:0071436)2.91129648
123activation of JUN kinase activity (GO:0007257)2.90489971
124negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90383161
125negative regulation of cell killing (GO:0031342)2.90383161
126GDP-mannose metabolic process (GO:0019673)2.88862490
127snRNA metabolic process (GO:0016073)2.87816424
128branched-chain amino acid catabolic process (GO:0009083)2.86781241
129focal adhesion assembly (GO:0048041)2.85068891
130cell-substrate adherens junction assembly (GO:0007045)2.85068891
131regulation of histone H3-K27 methylation (GO:0061085)2.84416261
132regulation of calcium ion transmembrane transport (GO:1903169)2.84163547
133regulation of calcium ion transmembrane transporter activity (GO:1901019)2.84163547
134negative regulation of potassium ion transport (GO:0043267)2.83895197
135negative regulation of myotube differentiation (GO:0010832)2.82577694
136regulation of sarcomere organization (GO:0060297)2.82549153
137negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82399512
138L-phenylalanine catabolic process (GO:0006559)2.81282788
139erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.81282788
140maternal placenta development (GO:0001893)2.80971390
141cardiac conduction (GO:0061337)2.80613263
142monocarboxylic acid catabolic process (GO:0072329)2.80064192
143T cell selection (GO:0045058)2.79772718
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78993906
145relaxation of cardiac muscle (GO:0055119)2.78929611
146regulation of heart rate by cardiac conduction (GO:0086091)2.77543562
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77506505
148negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.75579851
149regulation of heart rate (GO:0002027)2.74469195
150branched-chain amino acid metabolic process (GO:0009081)2.74027390
151mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73478954
152regulation of cardiac muscle contraction (GO:0055117)2.72296598
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72071167
154response to peptidoglycan (GO:0032494)2.71699255
155muscle hypertrophy (GO:0014896)2.71576310
156response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.71490614
157retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.71148961
158apoptotic process involved in development (GO:1902742)2.69308628
159muscle hypertrophy in response to stress (GO:0003299)2.69167850
160positive regulation of protein deacetylation (GO:0090312)2.63402350
161barbed-end actin filament capping (GO:0051016)2.60849504
162cellular response to virus (GO:0098586)2.60648508
163regulation of monocyte differentiation (GO:0045655)2.60552940
164peptidyl-arginine omega-N-methylation (GO:0035247)2.58681863
165pinocytosis (GO:0006907)2.58543203
166UV protection (GO:0009650)2.56734423
167activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55845828
168retrograde transport, endosome to Golgi (GO:0042147)2.55694422
169pentose-phosphate shunt (GO:0006098)2.55427672
170regulation of chromatin binding (GO:0035561)2.54938898
171snRNA processing (GO:0016180)2.54637746
172positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.54616844
173negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.54474878
174regulation of gamma-delta T cell activation (GO:0046643)2.54120662
175atrioventricular valve morphogenesis (GO:0003181)2.53607746
176regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53006203
177regulation of gamma-delta T cell differentiation (GO:0045586)2.51084729
178Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50919844
179epithelial cell differentiation involved in prostate gland development (GO:0060742)2.50739969
180negative thymic T cell selection (GO:0045060)2.49514866
181negative regulation of viral release from host cell (GO:1902187)2.49501522
182negative regulation of interleukin-2 production (GO:0032703)2.48476940
183poly(A)+ mRNA export from nucleus (GO:0016973)2.47010082
184positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46037910
185cell-cell junction maintenance (GO:0045217)2.45642845
186positive regulation of nuclease activity (GO:0032075)2.45257339
187regulation of glucose import in response to insulin stimulus (GO:2001273)2.44244822
188response to laminar fluid shear stress (GO:0034616)2.43261489
189regulation of defense response to virus by virus (GO:0050690)2.43074488
190detection of bacterium (GO:0016045)2.42676789
191regulation of NFAT protein import into nucleus (GO:0051532)2.41377416
192leukocyte aggregation (GO:0070486)2.41037130
193regulation of early endosome to late endosome transport (GO:2000641)2.40646034
194positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40344058
195embryonic process involved in female pregnancy (GO:0060136)2.40306382
196negative regulation of DNA-templated transcription, elongation (GO:0032785)2.38682632
197antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37627863
198mRNA stabilization (GO:0048255)2.36300472
199RNA stabilization (GO:0043489)2.36300472
200regulation of ARF protein signal transduction (GO:0032012)2.35210373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.52934794
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.35721839
3VDR_21846776_ChIP-Seq_THP-1_Human3.16726610
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.09487777
5* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.06449868
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.94059288
7MYC_22102868_ChIP-Seq_BL_Human2.92152058
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.70629239
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.66082150
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34187388
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27705530
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.24776010
13TBX20_22328084_ChIP-Seq_HEART_Mouse2.24776010
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.20317293
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.20055272
16ZNF263_19887448_ChIP-Seq_K562_Human2.19355586
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.07317830
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07047035
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04778060
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04427778
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04043994
22DROSHA_22980978_ChIP-Seq_HELA_Human1.97996172
23LXR_22292898_ChIP-Seq_THP-1_Human1.93864700
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.88953269
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85016303
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.84784094
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83679935
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80507393
29* KDM2B_26808549_Chip-Seq_DND41_Human1.79345722
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.78612365
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.78310977
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77735446
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.71699129
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69024188
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.67412813
36MAF_26560356_Chip-Seq_TH2_Human1.66413523
37MAF_26560356_Chip-Seq_TH1_Human1.66284592
38KDM2B_26808549_Chip-Seq_K562_Human1.66255386
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63240491
40VDR_24763502_ChIP-Seq_THP-1_Human1.62884361
41CTCF_27219007_Chip-Seq_Bcells_Human1.61928788
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61517533
43* ELF1_20517297_ChIP-Seq_JURKAT_Human1.58176461
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56392119
45UTX_26944678_Chip-Seq_JUKART_Human1.56324751
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52411384
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.51327880
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50770209
49RACK7_27058665_Chip-Seq_MCF-7_Human1.50766661
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50278534
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49590416
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49414657
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49362629
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48231744
55* P68_20966046_ChIP-Seq_HELA_Human1.47435386
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45847154
57* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44994244
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43800735
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43561413
60CREB1_26743006_Chip-Seq_LNCaP_Human1.41913336
61NCOR1_26117541_ChIP-Seq_K562_Human1.40167825
62* BCL6_27268052_Chip-Seq_Bcells_Human1.39787569
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.39063600
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.37972730
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37544948
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37143925
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35735190
68GATA1_19941826_ChIP-Seq_K562_Human1.32455040
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29248150
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28712694
71* TP63_22573176_ChIP-Seq_HFKS_Human1.28583784
72EZH2_22144423_ChIP-Seq_EOC_Human1.27450771
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24674131
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.23898526
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23890735
76SMC4_20622854_ChIP-Seq_HELA_Human1.23573852
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22919120
78* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21911874
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.21559544
80* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21328626
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21280812
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21261529
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20716759
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20341358
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20038297
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19706251
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18523982
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17420277
89CIITA_25753668_ChIP-Seq_RAJI_Human1.16968658
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.16907823
91* PHF8_20622854_ChIP-Seq_HELA_Human1.15311001
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14922356
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14912598
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14316165
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13905425
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13802996
97* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13302268
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.12576415
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.12547129
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12481645
101* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12403828
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11026207
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10951726
104CLOCK_20551151_ChIP-Seq_293T_Human1.09702021
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09637197
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09560374
107RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09560374
108XRN2_22483619_ChIP-Seq_HELA_Human1.09355849
109TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09175981
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08890613
111MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08410036
112* RARB_24833708_ChIP-Seq_LIVER_Mouse1.07252866
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07252215
114* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07037386
115CTCF_21964334_Chip-Seq_Bcells_Human1.06859742
116SA1_27219007_Chip-Seq_Bcells_Human1.06239243
117WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05671982
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.05445199
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05089925
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04788982
121RARA_24833708_ChIP-Seq_LIVER_Mouse1.04416152
122P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04377686
123TP53_22127205_ChIP-Seq_IMR90_Human1.03824433
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03685933
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03066181
126TCF7_22412390_ChIP-Seq_EML_Mouse1.02642581
127ELK3_25401928_ChIP-Seq_HUVEC_Human1.02466906
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01782277
129* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01056065
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00667028
131ISL1_27105846_Chip-Seq_CPCs_Mouse1.00253805
132* BCOR_27268052_Chip-Seq_Bcells_Human0.99775570
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99761787
134REST_18959480_ChIP-ChIP_MESCs_Mouse0.99207671
135MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99002953
136MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98896441
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98212100
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.96861890
139ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96787781
140SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96482532
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95653691
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94269583
143* KLF4_19829295_ChIP-Seq_ESCs_Human0.94008559
144* OCT4_19829295_ChIP-Seq_ESCs_Human0.93540635
145FOXO3_23340844_ChIP-Seq_DLD1_Human0.93405476
146CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92736752
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92428729
148AR_21572438_ChIP-Seq_LNCaP_Human0.91547204
149* E2F1_20622854_ChIP-Seq_HELA_Human0.90854539
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88508340
151ATF3_27146783_Chip-Seq_COLON_Human0.87826734
152SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87761061
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.86601965
154CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85212734
155ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84154640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.60599562
2MP0003646_muscle_fatigue4.55023931
3MP0000751_myopathy4.34308628
4MP0004084_abnormal_cardiac_muscle3.99025472
5MP0005058_abnormal_lysosome_morphology3.98713788
6MP0004215_abnormal_myocardial_fiber3.61579899
7MP0004036_abnormal_muscle_relaxation3.41060291
8MP0003172_abnormal_lysosome_physiology3.28984911
9MP0005330_cardiomyopathy3.13853527
10MP0003436_decreased_susceptibility_to3.12008276
11MP0009278_abnormal_bone_marrow3.11817289
12MP0008260_abnormal_autophagy3.10319901
13MP0001849_ear_inflammation2.95182858
14MP0000749_muscle_degeneration2.94220773
15MP0005360_urolithiasis2.78665612
16MP0004087_abnormal_muscle_fiber2.59537094
17MP0004130_abnormal_muscle_cell2.55532461
18MP0003137_abnormal_impulse_conducting2.37311178
19MP0003303_peritoneal_inflammation2.32581435
20MP0004858_abnormal_nervous_system2.30274319
21MP0002972_abnormal_cardiac_muscle2.26409102
22MP0002269_muscular_atrophy2.21492506
23MP0005076_abnormal_cell_differentiation2.20324286
24MP0000747_muscle_weakness2.19665455
25MP0000678_abnormal_parathyroid_gland2.18368923
26MP0005620_abnormal_muscle_contractility2.15213855
27MP0008775_abnormal_heart_ventricle2.15004332
28MP0002822_catalepsy2.12415523
29MP0004233_abnormal_muscle_weight2.10587259
30MP0010630_abnormal_cardiac_muscle2.02541655
31MP0004145_abnormal_muscle_electrophysio2.00582567
32MP0005085_abnormal_gallbladder_physiolo1.97669942
33MP0000750_abnormal_muscle_regeneration1.95643708
34MP0002106_abnormal_muscle_physiology1.94101878
35MP0002139_abnormal_hepatobiliary_system1.92900684
36MP0004043_abnormal_pH_regulation1.92338596
37MP0009333_abnormal_splenocyte_physiolog1.91543681
38MP0004947_skin_inflammation1.88112942
39MP0005666_abnormal_adipose_tissue1.85417275
40MP0004085_abnormal_heartbeat1.85055069
41MP0003763_abnormal_thymus_physiology1.83949800
42MP0005365_abnormal_bile_salt1.83432272
43MP0001544_abnormal_cardiovascular_syste1.82859081
44MP0005385_cardiovascular_system_phenoty1.82859081
45MP0004484_altered_response_of1.78077130
46MP0006036_abnormal_mitochondrial_physio1.76506424
47MP0001873_stomach_inflammation1.75418727
48MP0006138_congestive_heart_failure1.74103538
49MP0000858_altered_metastatic_potential1.70640942
50MP0002249_abnormal_larynx_morphology1.70196139
51MP0003950_abnormal_plasma_membrane1.69781398
52MP0005551_abnormal_eye_electrophysiolog1.68880811
53MP0000759_abnormal_skeletal_muscle1.68718108
54MP0005670_abnormal_white_adipose1.59510930
55MP0004185_abnormal_adipocyte_glucose1.54406415
56MP0005369_muscle_phenotype1.52280790
57MP0005025_abnormal_response_to1.52142674
58MP0003453_abnormal_keratinocyte_physiol1.52121619
59MP0009384_cardiac_valve_regurgitation1.48995160
60MP0001348_abnormal_lacrimal_gland1.47849500
61MP0008875_abnormal_xenobiotic_pharmacok1.47772338
62MP0002396_abnormal_hematopoietic_system1.47217001
63MP0001545_abnormal_hematopoietic_system1.44675657
64MP0005397_hematopoietic_system_phenotyp1.44675657
65MP0002419_abnormal_innate_immunity1.41260930
66MP0005332_abnormal_amino_acid1.41074280
67MP0005000_abnormal_immune_tolerance1.38762253
68MP0008961_abnormal_basal_metabolism1.37908199
69MP0002332_abnormal_exercise_endurance1.36902740
70MP0009840_abnormal_foam_cell1.36100574
71MP0003221_abnormal_cardiomyocyte_apopto1.34983583
72MP0003806_abnormal_nucleotide_metabolis1.34380454
73MP0003279_aneurysm1.34248934
74MP0003566_abnormal_cell_adhesion1.33643067
75MP0000685_abnormal_immune_system1.33576362
76MP0004381_abnormal_hair_follicle1.32039087
77MP0002398_abnormal_bone_marrow1.30124886
78MP0002234_abnormal_pharynx_morphology1.29852248
79MP0002796_impaired_skin_barrier1.29842584
80MP0001800_abnormal_humoral_immune1.29547340
81MP0001819_abnormal_immune_cell1.29209091
82MP0002254_reproductive_system_inflammat1.28803606
83MP0002420_abnormal_adaptive_immunity1.28751313
84MP0005375_adipose_tissue_phenotype1.28615518
85MP0000703_abnormal_thymus_morphology1.26604346
86MP0003252_abnormal_bile_duct1.25593906
87MP0005083_abnormal_biliary_tract1.24054696
88MP0002723_abnormal_immune_serum1.22094997
89MP0010155_abnormal_intestine_physiology1.20990520
90MP0005501_abnormal_skin_physiology1.20825074
91MP0001533_abnormal_skeleton_physiology1.19746388
92MP0002452_abnormal_antigen_presenting1.18115258
93MP0002933_joint_inflammation1.17600119
94MP0006072_abnormal_retinal_apoptosis1.16983882
95MP0003283_abnormal_digestive_organ1.16906162
96MP0000490_abnormal_crypts_of1.16834614
97MP0005387_immune_system_phenotype1.16604760
98MP0001790_abnormal_immune_system1.16604760
99MP0003011_delayed_dark_adaptation1.16588297
100MP0002877_abnormal_melanocyte_morpholog1.16365036
101MP0000716_abnormal_immune_system1.15792573
102MP0003300_gastrointestinal_ulcer1.14563557
103MP0006035_abnormal_mitochondrial_morpho1.14524662
104MP0005409_darkened_coat_color1.14507720
105MP0002127_abnormal_cardiovascular_syste1.14243598
106MP0001666_abnormal_nutrient_absorption1.13919633
107MP0001835_abnormal_antigen_presentation1.11000317
108MP0002429_abnormal_blood_cell1.10509520
109MP0005671_abnormal_response_to1.07180564
110MP0002722_abnormal_immune_system1.07113544
111MP0002405_respiratory_system_inflammati1.07005018
112MP0002118_abnormal_lipid_homeostasis1.05856754
113MP0010329_abnormal_lipoprotein_level1.03457222
114MP0005451_abnormal_body_composition1.02538247
115MP0003828_pulmonary_edema1.01899044
116MP0010234_abnormal_vibrissa_follicle1.01644781
117MP0004510_myositis1.01173194
118MP0004264_abnormal_extraembryonic_tissu1.00246382
119MP0000733_abnormal_muscle_development1.00144705
120MP0002089_abnormal_postnatal_growth/wei0.99626817
121MP0004808_abnormal_hematopoietic_stem0.99583401
122MP0004859_abnormal_synaptic_plasticity0.98842654
123MP0002998_abnormal_bone_remodeling0.98616233
124MP0003705_abnormal_hypodermis_morpholog0.96194000
125MP0005464_abnormal_platelet_physiology0.95531362
126MP0005266_abnormal_metabolism0.94386906
127MP0009931_abnormal_skin_appearance0.93840531
128MP0001853_heart_inflammation0.92935888
129MP0002909_abnormal_adrenal_gland0.92781703
130MP0003329_amyloid_beta_deposits0.92746637
131MP0003195_calcinosis0.91104433
132MP0003091_abnormal_cell_migration0.90902407
133MP0002971_abnormal_brown_adipose0.90223202
134MP0005621_abnormal_cell_physiology0.89748462
135MP0003111_abnormal_nucleus_morphology0.88796366
136MP0003183_abnormal_peptide_metabolism0.88110942
137MP0000689_abnormal_spleen_morphology0.85918936
138MP0010030_abnormal_orbit_morphology0.84445527
139MP0001730_embryonic_growth_arrest0.84435404
140MP0001765_abnormal_ion_homeostasis0.84132403
141MP0002229_neurodegeneration0.84110217
142MP0000230_abnormal_systemic_arterial0.83507057
143MP0005319_abnormal_enzyme/_coenzyme0.82807213
144MP0000266_abnormal_heart_morphology0.82730004
145MP0005390_skeleton_phenotype0.82528908
146MP0005584_abnormal_enzyme/coenzyme_acti0.81264431
147MP0003866_abnormal_defecation0.81147384
148MP0002078_abnormal_glucose_homeostasis0.80862889
149MP0000313_abnormal_cell_death0.79254983
150MP0005253_abnormal_eye_physiology0.78624206
151MP0000537_abnormal_urethra_morphology0.78383634
152MP0000003_abnormal_adipose_tissue0.78198665
153MP0001958_emphysema0.77386249
154MP0009643_abnormal_urine_homeostasis0.76474884
155MP0001663_abnormal_digestive_system0.75513713
156MP0008569_lethality_at_weaning0.75338372
157MP0001845_abnormal_inflammatory_respons0.74719951
158MP0005535_abnormal_body_temperature0.74001419
159MP0004270_analgesia0.73442283
160MP0000681_abnormal_thyroid_gland0.73364549
161MP0000013_abnormal_adipose_tissue0.73261475
162MP0000767_abnormal_smooth_muscle0.73001697
163MP0005165_increased_susceptibility_to0.72706755
164MP0005023_abnormal_wound_healing0.72542827
165MP0002970_abnormal_white_adipose0.71641325
166MP0002060_abnormal_skin_morphology0.70778822
167MP0002019_abnormal_tumor_incidence0.70327281
168MP0002090_abnormal_vision0.69918106
169MP0002132_abnormal_respiratory_system0.69778362
170MP0002148_abnormal_hypersensitivity_rea0.69293310
171MP0004885_abnormal_endolymph0.68829786
172MP0003191_abnormal_cellular_cholesterol0.68238440
173MP0000609_abnormal_liver_physiology0.65758377
174MP0005386_behavior/neurological_phenoty0.65565576
175MP0004924_abnormal_behavior0.65565576
176MP0005187_abnormal_penis_morphology0.64282502
177MP0003656_abnormal_erythrocyte_physiolo0.60795876
178MP0004019_abnormal_vitamin_homeostasis0.59520622
179MP0005167_abnormal_blood-brain_barrier0.58824440
180MP0003635_abnormal_synaptic_transmissio0.58726494
181MP0008874_decreased_physiological_sensi0.58725154
182MP0009780_abnormal_chondrocyte_physiolo0.58355785
183MP0002272_abnormal_nervous_system0.57442050
184MP0002064_seizures0.54503197
185MP0005195_abnormal_posterior_eye0.53693099
186MP0000920_abnormal_myelination0.51587485

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.24869653
2Exercise-induced myalgia (HP:0003738)5.41536989
3Ventricular tachycardia (HP:0004756)4.95903739
4Exercise-induced muscle cramps (HP:0003710)4.89659152
5Calf muscle hypertrophy (HP:0008981)4.87599444
6Myoglobinuria (HP:0002913)4.83303564
7Muscle hypertrophy of the lower extremities (HP:0008968)4.73992153
8Atrial fibrillation (HP:0005110)4.43332679
9Muscle fiber splitting (HP:0003555)4.39549040
10Hyporeflexia of lower limbs (HP:0002600)4.35603848
11Syncope (HP:0001279)4.17485510
12Primary atrial arrhythmia (HP:0001692)4.13033716
13Bundle branch block (HP:0011710)3.98248661
14Supraventricular tachycardia (HP:0004755)3.96661160
15Supraventricular arrhythmia (HP:0005115)3.86883901
16Abnormality of the calf musculature (HP:0001430)3.83310543
17Right ventricular cardiomyopathy (HP:0011663)3.76619179
18Prolonged QT interval (HP:0001657)3.72930014
19Obstructive sleep apnea (HP:0002870)3.71294858
20Broad face (HP:0000283)3.70488480
21J-shaped sella turcica (HP:0002680)3.62616402
22Lipoatrophy (HP:0100578)3.56183608
23Abnormality of the left ventricular outflow tract (HP:0011103)3.49805696
24Subaortic stenosis (HP:0001682)3.49805696
25Palpitations (HP:0001962)3.47466016
26Difficulty running (HP:0009046)3.46525762
27Ketoacidosis (HP:0001993)3.45471310
28Ventricular fibrillation (HP:0001663)3.41593557
29Central scotoma (HP:0000603)3.39504706
30Rhabdomyolysis (HP:0003201)3.31736719
31Cervical subluxation (HP:0003308)3.28549751
32Heart block (HP:0012722)3.26529940
33Stridor (HP:0010307)3.25198317
34Ventricular arrhythmia (HP:0004308)3.24373034
35Atrioventricular block (HP:0001678)3.22726449
36EMG: myopathic abnormalities (HP:0003458)3.21323901
37Dilated cardiomyopathy (HP:0001644)3.19459221
38Hyperacusis (HP:0010780)3.17649152
39Ketosis (HP:0001946)3.14745053
40Hyperglycinuria (HP:0003108)3.08070431
41Biconcave vertebral bodies (HP:0004586)3.05818198
42Dysostosis multiplex (HP:0000943)2.97895840
43Abnormal atrioventricular conduction (HP:0005150)2.93885145
44Hypoglycemic coma (HP:0001325)2.86966198
45Asymmetric septal hypertrophy (HP:0001670)2.86120652
46Eczematoid dermatitis (HP:0000976)2.81950475
47Dysmetric saccades (HP:0000641)2.81133635
48Cerebral aneurysm (HP:0004944)2.80822958
49Distal lower limb amyotrophy (HP:0008944)2.78783681
50Increased connective tissue (HP:0009025)2.75538002
51Hyperammonemia (HP:0001987)2.73223969
52Thin bony cortex (HP:0002753)2.72201274
53Muscle stiffness (HP:0003552)2.71184920
54Abnormality of glycine metabolism (HP:0010895)2.70808064
55Abnormality of serine family amino acid metabolism (HP:0010894)2.70808064
56Abnormality of fatty-acid metabolism (HP:0004359)2.70520855
57Colitis (HP:0002583)2.70351188
58Myotonia (HP:0002486)2.69595480
59Abnormal EKG (HP:0003115)2.62323290
60Abnormality of the thoracic spine (HP:0100711)2.61118379
61Broad distal phalanx of finger (HP:0009836)2.60171763
62Dicarboxylic aciduria (HP:0003215)2.59374231
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59374231
64Cellulitis (HP:0100658)2.56698404
65Ulnar bowing (HP:0003031)2.49830338
66Upper limb amyotrophy (HP:0009129)2.47330275
67Distal upper limb amyotrophy (HP:0007149)2.47330275
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43476822
69Abnormality of polysaccharide metabolism (HP:0011012)2.43476822
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43476822
71Obstructive lung disease (HP:0006536)2.41468046
72Chronic obstructive pulmonary disease (HP:0006510)2.41468046
73Scotoma (HP:0000575)2.40640499
74Congenital stationary night blindness (HP:0007642)2.38530436
75Cholelithiasis (HP:0001081)2.38477058
76Urinary glycosaminoglycan excretion (HP:0003541)2.37759111
77Mucopolysacchariduria (HP:0008155)2.37759111
78Difficulty climbing stairs (HP:0003551)2.37240312
79Gout (HP:0001997)2.37009237
80Hypertensive crisis (HP:0100735)2.36602982
81Increased IgE level (HP:0003212)2.35609157
82Gastrointestinal inflammation (HP:0004386)2.35376272
83Truncus arteriosus (HP:0001660)2.33075199
84Ragged-red muscle fibers (HP:0003200)2.30769011
85Left ventricular hypertrophy (HP:0001712)2.30740197
86Joint stiffness (HP:0001387)2.29850114
87Long palpebral fissure (HP:0000637)2.28676765
88Hyperinsulinemic hypoglycemia (HP:0000825)2.27218868
89Myopathic facies (HP:0002058)2.24523839
90Increased muscle lipid content (HP:0009058)2.24399590
91Metaphyseal cupping (HP:0003021)2.22952767
92Seborrheic dermatitis (HP:0001051)2.22089608
93Thoracic kyphosis (HP:0002942)2.20716145
94Hemorrhage of the eye (HP:0011885)2.18384561
95Increased cerebral lipofuscin (HP:0011813)2.18110362
96Distal lower limb muscle weakness (HP:0009053)2.17992089
97Centrally nucleated skeletal muscle fibers (HP:0003687)2.16523154
98Atelectasis (HP:0100750)2.16389214
99Achilles tendon contracture (HP:0001771)2.15694878
100Reticulocytosis (HP:0001923)2.15177209
101Increased variability in muscle fiber diameter (HP:0003557)2.15126635
102Abnormal gallbladder morphology (HP:0012437)2.14810387
103Protrusio acetabuli (HP:0003179)2.14256924
104Easy fatigability (HP:0003388)2.13824103
105Disproportionate tall stature (HP:0001519)2.13132063
106Hyperglycinemia (HP:0002154)2.09775290
107Vertebral compression fractures (HP:0002953)2.09560772
108Cerebral edema (HP:0002181)2.07694218
109EMG: neuropathic changes (HP:0003445)2.06608627
110Abnormality of the fingertips (HP:0001211)2.06516748
111Metabolic acidosis (HP:0001942)2.03575715
112Spinal cord lesions (HP:0100561)2.03023600
113Syringomyelia (HP:0003396)2.03023600
114Mitral regurgitation (HP:0001653)2.02328548
115Hamartoma of the eye (HP:0010568)2.01801658
116Pheochromocytoma (HP:0002666)2.01478509
117Loss of speech (HP:0002371)2.01458063
118Increased neuronal autofluorescent lipopigment (HP:0002074)2.00978481
119Nuclear cataract (HP:0100018)1.98035666
120Testicular atrophy (HP:0000029)1.97613798
121Acute encephalopathy (HP:0006846)1.96357354
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96219152
123Inflammation of the large intestine (HP:0002037)1.95946573
124Pointed chin (HP:0000307)1.94793230
125Emphysema (HP:0002097)1.93928029
126Athetosis (HP:0002305)1.93808243
127Hepatic necrosis (HP:0002605)1.91890727
128Flat acetabular roof (HP:0003180)1.91730515
129Interstitial pulmonary disease (HP:0006530)1.91721238
130Deformed sella turcica (HP:0002681)1.90941795
131Polygenic inheritance (HP:0010982)1.89483507
132Cholecystitis (HP:0001082)1.88810056
133Abnormal gallbladder physiology (HP:0012438)1.88810056
134Flattened epiphyses (HP:0003071)1.88004107
135Abnormality of macrophages (HP:0004311)1.87718420
136Selective tooth agenesis (HP:0001592)1.87386994
137Recurrent abscess formation (HP:0002722)1.87121925
138Pigmentary retinal degeneration (HP:0001146)1.86814700
139Xanthomatosis (HP:0000991)1.85405933
140Abnormality of the Achilles tendon (HP:0005109)1.84428614
141Limb-girdle muscle atrophy (HP:0003797)1.84323642
142Mediastinal lymphadenopathy (HP:0100721)1.84199165
143Hyperlipoproteinemia (HP:0010980)1.84001711
144Gastrointestinal dysmotility (HP:0002579)1.83003218
145Hyperthyroidism (HP:0000836)1.82671600
146Intrahepatic cholestasis (HP:0001406)1.82057514
147Conjunctival hamartoma (HP:0100780)1.81633783
148Increased intramyocellular lipid droplets (HP:0012240)1.81513735
149Neuronal loss in central nervous system (HP:0002529)1.81218822
150Recurrent bacterial skin infections (HP:0005406)1.80910548
151Annular pancreas (HP:0001734)1.80639615
152Abnormality of skeletal muscle fiber size (HP:0012084)1.80267027
153Large for gestational age (HP:0001520)1.78462001
154Agammaglobulinemia (HP:0004432)1.78135836
155Hypertriglyceridemia (HP:0002155)1.76346307
156Late onset (HP:0003584)1.74517986
157Deep venous thrombosis (HP:0002625)1.74189888
158Premature skin wrinkling (HP:0100678)1.73767971
159Hand muscle atrophy (HP:0009130)1.73677614
160Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73560927
161Abnormal mitochondria in muscle tissue (HP:0008316)1.73507287
162Gingivitis (HP:0000230)1.73176057
163Premature rupture of membranes (HP:0001788)1.73168458
164Increased serum ferritin (HP:0003281)1.72698223
165Bony spicule pigmentary retinopathy (HP:0007737)1.72433152
166Palmoplantar keratoderma (HP:0000982)1.72255798
167Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70741860
168Lymphangioma (HP:0100764)1.70646576
169Turricephaly (HP:0000262)1.70250880
170Shallow orbits (HP:0000586)1.70201445
171Abnormality of the foot musculature (HP:0001436)1.67874004
172Long toe (HP:0010511)1.67839060
173Gastrointestinal stroma tumor (HP:0100723)1.67557022
174Lethargy (HP:0001254)1.67426570
175Hepatosplenomegaly (HP:0001433)1.66867114
176Bulbar palsy (HP:0001283)1.66349193
177Rectal prolapse (HP:0002035)1.66320009
178Sudden cardiac death (HP:0001645)1.64864223
179Lower limb amyotrophy (HP:0007210)1.64720242
180Myositis (HP:0100614)1.63304837
181Foot dorsiflexor weakness (HP:0009027)1.63300500
182Spinal canal stenosis (HP:0003416)1.63105470
183Abnormality of macular pigmentation (HP:0008002)1.62607210
184Microvesicular hepatic steatosis (HP:0001414)1.61890808
185Pancreatic islet-cell hyperplasia (HP:0004510)1.61619514
186Aneurysm (HP:0002617)1.61331561
187Vomiting (HP:0002013)1.61315350
188Hyperkalemia (HP:0002153)1.61187671
189Skin nodule (HP:0200036)1.58590679
190Rapidly progressive (HP:0003678)1.58249902
191Areflexia of lower limbs (HP:0002522)1.58005489
192Increased purine levels (HP:0004368)1.57899656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.25365128
2LMTK24.10628374
3PHKG13.31074968
4PHKG23.31074968
5SMG13.22824115
6TRIB33.04705366
7BCKDK2.94665749
8PKN22.86101522
9PRPF4B2.69943939
10WNK42.58587889
11MAP2K32.46972234
12OBSCN2.37460380
13MAP4K12.32839879
14NME22.27931905
15DMPK2.22533975
16PDK42.04978733
17PDK32.04978733
18MAP3K131.96650231
19MYLK1.87152630
20ICK1.86327363
21IRAK31.86140066
22MAP3K71.81201332
23TAOK31.75367100
24PINK11.75215938
25NEK11.73511239
26STK391.70710494
27MAP3K111.65260175
28TNK21.51984346
29KSR21.49264504
30WNK11.41777391
31RIPK41.41375351
32PRKD11.35415824
33TBK11.34791264
34TESK21.33983550
35PAK31.28340360
36PIK3CA1.25670120
37STK381.22861885
38MAP3K101.20438098
39ZAP701.19179476
40EPHB11.18662770
41RIPK11.18604565
42TYK21.18584297
43TAOK21.17228529
44PRKD31.14983103
45MAP3K61.14007250
46TESK11.10464158
47PAK61.08938155
48PRKAA11.08358711
49EPHA21.06120976
50BMX1.06021481
51MAP2K61.05791662
52IRAK41.05614569
53MAPK121.04425721
54PRKAA21.03346492
55CDC42BPA1.02768792
56CAMK2D1.02759557
57MAP3K141.02452249
58SIK11.02238808
59PDK21.01432807
60EPHA41.01111327
61JAK31.01078887
62CDK121.00630019
63RPS6KA20.98742253
64MAP3K30.96203197
65PDPK10.94480808
66RPS6KL10.94275676
67KDR0.94047761
68PKN10.93175116
69TAOK10.91565797
70CAMK1G0.90232435
71SIK30.88550203
72ERN10.87890257
73OXSR10.86476246
74PDGFRA0.85910703
75INSRR0.85187045
76BTK0.83307536
77TYRO30.82770014
78PAK40.81144718
79PRKCH0.80308208
80PTK60.79976630
81BLK0.79319156
82PDK10.78236755
83CAMK40.76790786
84ARAF0.76613586
85GRK60.76500680
86CDK40.76441778
87PRKD20.75860553
88EEF2K0.74671782
89MARK20.74069487
90CAMKK10.73554047
91RPS6KA60.70999798
92SGK30.70914735
93MAP2K40.70592060
94PTK20.68835056
95MAP3K40.68473217
96NTRK10.67868329
97STK110.66851599
98MST1R0.66550541
99MAPK150.66477853
100LRRK20.65045718
101FGFR40.63951768
102ROCK20.63950044
103IKBKE0.63126101
104MTOR0.62801891
105HIPK20.62711658
106SGK2230.62350496
107SGK4940.62350496
108DYRK1B0.61462779
109CSK0.61061484
110ROCK10.60536664
111CAMK1D0.58411160
112TIE10.57880629
113ALK0.57166079
114PIM20.57137987
115RPS6KB20.55878827
116UHMK10.54513348
117CAMK2A0.53324407
118PTK2B0.52970790
119MAP3K90.52769653
120IKBKB0.52439406
121FES0.52341077
122RET0.52101743
123MAP2K20.51568750
124ILK0.51506290
125CDK70.51376900
126MAP3K80.50928047
127IRAK20.50786764
128PRKACG0.50563055
129MAPK110.50252835
130CAMK10.49452888
131HCK0.49133737
132NME10.48305091
133GRK10.48033261
134MAPK70.47359235
135PRKACB0.47007974
136MAP3K10.46683367
137AKT20.45302209
138GRK70.45283850
139CAMK2G0.44723443
140DAPK30.44177346
141DAPK20.43922755
142RPS6KA10.43187207
143MUSK0.42183545
144MATK0.41322771
145RPS6KA30.41013351
146SIK20.40758313
147ITK0.40524284
148MAPKAPK20.39842948
149BRAF0.39294241
150WNK30.38849787
151SGK10.38766300
152PRKG20.37799760
153LCK0.36487622
154PRKACA0.36458406
155DDR20.35354356
156MAP3K20.33769864
157NTRK30.33735834
158MAPKAPK30.32887481
159JAK20.32763294
160RPS6KC10.30720074
161CSF1R0.30314504
162SYK0.30185598
163CHUK0.29882031

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.05249265
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.81126968
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.76310037
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.58333669
5Propanoate metabolism_Homo sapiens_hsa006402.87249503
6Fatty acid degradation_Homo sapiens_hsa000712.68964809
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61528465
8Cardiac muscle contraction_Homo sapiens_hsa042602.54840301
9Acute myeloid leukemia_Homo sapiens_hsa052212.39920300
10Nitrogen metabolism_Homo sapiens_hsa009102.35148936
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.34876632
12Notch signaling pathway_Homo sapiens_hsa043302.25791555
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24860694
14Fatty acid metabolism_Homo sapiens_hsa012122.10266945
15Carbon metabolism_Homo sapiens_hsa012002.09654647
16Butanoate metabolism_Homo sapiens_hsa006502.07125742
17Dilated cardiomyopathy_Homo sapiens_hsa054141.96157984
18VEGF signaling pathway_Homo sapiens_hsa043701.95050992
19B cell receptor signaling pathway_Homo sapiens_hsa046621.94470323
20Arginine biosynthesis_Homo sapiens_hsa002201.94194124
21Pyruvate metabolism_Homo sapiens_hsa006201.91656589
22Phototransduction_Homo sapiens_hsa047441.85060686
23Chronic myeloid leukemia_Homo sapiens_hsa052201.82271582
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.76382578
25Non-small cell lung cancer_Homo sapiens_hsa052231.69221577
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67935546
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66110093
28Osteoclast differentiation_Homo sapiens_hsa043801.59069909
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56842180
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56439689
31Tryptophan metabolism_Homo sapiens_hsa003801.52430300
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48938267
33Bladder cancer_Homo sapiens_hsa052191.48498249
34PPAR signaling pathway_Homo sapiens_hsa033201.44610487
35Parkinsons disease_Homo sapiens_hsa050121.42980407
36Leishmaniasis_Homo sapiens_hsa051401.41348461
37Biosynthesis of amino acids_Homo sapiens_hsa012301.39986674
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38788669
39Fatty acid elongation_Homo sapiens_hsa000621.34866955
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34625565
41Oxidative phosphorylation_Homo sapiens_hsa001901.33881838
42Bile secretion_Homo sapiens_hsa049761.33392373
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.32947717
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30324727
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27272485
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.27260763
47Base excision repair_Homo sapiens_hsa034101.27125564
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27011393
49Lysine degradation_Homo sapiens_hsa003101.26326776
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.26232344
51Pentose phosphate pathway_Homo sapiens_hsa000301.25486405
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23996773
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23258855
54Lysosome_Homo sapiens_hsa041421.18398956
55Pancreatic cancer_Homo sapiens_hsa052121.18354236
56Hepatitis C_Homo sapiens_hsa051601.15629476
57Primary immunodeficiency_Homo sapiens_hsa053401.13803986
58TNF signaling pathway_Homo sapiens_hsa046681.12577639
59Alzheimers disease_Homo sapiens_hsa050101.11560532
60T cell receptor signaling pathway_Homo sapiens_hsa046601.10924496
61NF-kappa B signaling pathway_Homo sapiens_hsa040641.09612011
62Toxoplasmosis_Homo sapiens_hsa051451.09107728
63Phospholipase D signaling pathway_Homo sapiens_hsa040721.07330962
64Apoptosis_Homo sapiens_hsa042101.05612055
65Influenza A_Homo sapiens_hsa051641.03613483
66Choline metabolism in cancer_Homo sapiens_hsa052311.03485414
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03110791
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02740064
69beta-Alanine metabolism_Homo sapiens_hsa004101.01750482
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01434682
71Hepatitis B_Homo sapiens_hsa051611.01196569
72Endometrial cancer_Homo sapiens_hsa052131.00598806
73Herpes simplex infection_Homo sapiens_hsa051680.99461911
74Starch and sucrose metabolism_Homo sapiens_hsa005000.98657258
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.97003443
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96708047
77Glioma_Homo sapiens_hsa052140.95966128
78Peroxisome_Homo sapiens_hsa041460.95804148
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95617102
80Fat digestion and absorption_Homo sapiens_hsa049750.94876860
81Shigellosis_Homo sapiens_hsa051310.93154371
82Glycerolipid metabolism_Homo sapiens_hsa005610.92063129
83Tuberculosis_Homo sapiens_hsa051520.91940933
84HTLV-I infection_Homo sapiens_hsa051660.91594004
85ErbB signaling pathway_Homo sapiens_hsa040120.91465779
86Glucagon signaling pathway_Homo sapiens_hsa049220.90501175
87Prion diseases_Homo sapiens_hsa050200.89763789
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88904364
89Arginine and proline metabolism_Homo sapiens_hsa003300.88586781
90Insulin resistance_Homo sapiens_hsa049310.88552625
91Prolactin signaling pathway_Homo sapiens_hsa049170.85489600
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.84111700
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82717510
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82223459
95Thyroid cancer_Homo sapiens_hsa052160.81826398
96Small cell lung cancer_Homo sapiens_hsa052220.81533254
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80328351
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80215906
99Gastric acid secretion_Homo sapiens_hsa049710.79329105
100Sulfur metabolism_Homo sapiens_hsa009200.78124662
101Inositol phosphate metabolism_Homo sapiens_hsa005620.77858850
102Endocytosis_Homo sapiens_hsa041440.77449407
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.77392691
104Phenylalanine metabolism_Homo sapiens_hsa003600.75336436
105Epstein-Barr virus infection_Homo sapiens_hsa051690.75235910
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74582381
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.74268749
108Viral carcinogenesis_Homo sapiens_hsa052030.73920603
109Insulin secretion_Homo sapiens_hsa049110.73685521
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73496849
111Type II diabetes mellitus_Homo sapiens_hsa049300.73221995
112AMPK signaling pathway_Homo sapiens_hsa041520.72903158
113Insulin signaling pathway_Homo sapiens_hsa049100.72757332
114ABC transporters_Homo sapiens_hsa020100.72288119
115Salmonella infection_Homo sapiens_hsa051320.71434220
116Fructose and mannose metabolism_Homo sapiens_hsa000510.69707644
117Renal cell carcinoma_Homo sapiens_hsa052110.67415110
118Colorectal cancer_Homo sapiens_hsa052100.67070168
119HIF-1 signaling pathway_Homo sapiens_hsa040660.65938981
120Fatty acid biosynthesis_Homo sapiens_hsa000610.65224191
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64526083
122Estrogen signaling pathway_Homo sapiens_hsa049150.63903287
123Measles_Homo sapiens_hsa051620.63208536
124Renin secretion_Homo sapiens_hsa049240.62262223
125Huntingtons disease_Homo sapiens_hsa050160.61670645
126GABAergic synapse_Homo sapiens_hsa047270.60316435
127Chemokine signaling pathway_Homo sapiens_hsa040620.60072930
128Oxytocin signaling pathway_Homo sapiens_hsa049210.59747447
129DNA replication_Homo sapiens_hsa030300.58893031
130Amoebiasis_Homo sapiens_hsa051460.57477293
131Olfactory transduction_Homo sapiens_hsa047400.57330466
132Prostate cancer_Homo sapiens_hsa052150.57275588
133mRNA surveillance pathway_Homo sapiens_hsa030150.57097670
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56566751
135Allograft rejection_Homo sapiens_hsa053300.56513938
136Pertussis_Homo sapiens_hsa051330.56159028
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.54557034
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54100984
139Calcium signaling pathway_Homo sapiens_hsa040200.53578140
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53504179
141Circadian entrainment_Homo sapiens_hsa047130.53039759
142Salivary secretion_Homo sapiens_hsa049700.52964648
143Focal adhesion_Homo sapiens_hsa045100.52456586
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.51225197
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51167783
146Platelet activation_Homo sapiens_hsa046110.51137557
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49504553
148Pancreatic secretion_Homo sapiens_hsa049720.48990134
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.47855369
150Intestinal immune network for IgA production_Homo sapiens_hsa046720.47845637
151Galactose metabolism_Homo sapiens_hsa000520.47584777
152cAMP signaling pathway_Homo sapiens_hsa040240.46939867
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46586015
154Autoimmune thyroid disease_Homo sapiens_hsa053200.46188116
155MAPK signaling pathway_Homo sapiens_hsa040100.46062133
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45887104
157Malaria_Homo sapiens_hsa051440.45795498
158Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44997688
159Morphine addiction_Homo sapiens_hsa050320.44754627
160Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43142375
161Tyrosine metabolism_Homo sapiens_hsa003500.42580762
162Dorso-ventral axis formation_Homo sapiens_hsa043200.42408265
163Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42305817
164Glycerophospholipid metabolism_Homo sapiens_hsa005640.40114617
165Sulfur relay system_Homo sapiens_hsa041220.39036459
166Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37456737
167mTOR signaling pathway_Homo sapiens_hsa041500.35634521
168Viral myocarditis_Homo sapiens_hsa054160.35238556
169Glutamatergic synapse_Homo sapiens_hsa047240.34387609
170Cholinergic synapse_Homo sapiens_hsa047250.33756640
171Long-term potentiation_Homo sapiens_hsa047200.32954166
172Histidine metabolism_Homo sapiens_hsa003400.32584341
173Dopaminergic synapse_Homo sapiens_hsa047280.29165880
174Caffeine metabolism_Homo sapiens_hsa002320.28406802
175Circadian rhythm_Homo sapiens_hsa047100.28230395
176Mineral absorption_Homo sapiens_hsa049780.27809763
177Tight junction_Homo sapiens_hsa045300.27637677
178Gap junction_Homo sapiens_hsa045400.24480899
179GnRH signaling pathway_Homo sapiens_hsa049120.24397772

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