RHOU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.23777092
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.23777092
3fatty acid elongation (GO:0030497)5.75189726
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.73991741
5L-phenylalanine metabolic process (GO:0006558)5.73991741
6central nervous system myelination (GO:0022010)5.72040159
7axon ensheathment in central nervous system (GO:0032291)5.72040159
8aromatic amino acid family catabolic process (GO:0009074)4.74585556
9alpha-linolenic acid metabolic process (GO:0036109)4.69724492
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.20142206
11bile acid biosynthetic process (GO:0006699)4.19456850
12cholesterol biosynthetic process (GO:0006695)4.09623860
13very long-chain fatty acid metabolic process (GO:0000038)4.08857410
14long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.06808603
15fatty-acyl-CoA biosynthetic process (GO:0046949)4.00824904
16glyoxylate metabolic process (GO:0046487)3.90736962
17coenzyme catabolic process (GO:0009109)3.83836511
18heme transport (GO:0015886)3.80154420
19cysteine metabolic process (GO:0006534)3.77342871
20high-density lipoprotein particle remodeling (GO:0034375)3.72951377
21negative regulation of fibrinolysis (GO:0051918)3.71477832
22fatty-acyl-CoA metabolic process (GO:0035337)3.68164010
23peptidyl-glutamic acid carboxylation (GO:0017187)3.66209390
24protein carboxylation (GO:0018214)3.66209390
25sulfur amino acid catabolic process (GO:0000098)3.62351620
26sterol biosynthetic process (GO:0016126)3.62022196
27bile acid metabolic process (GO:0008206)3.61490791
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.59607687
29regulation of triglyceride catabolic process (GO:0010896)3.58607681
30regulation of fibrinolysis (GO:0051917)3.57732267
31complement activation, alternative pathway (GO:0006957)3.54649313
32tyrosine metabolic process (GO:0006570)3.54431924
33kynurenine metabolic process (GO:0070189)3.53034588
34response to methylmercury (GO:0051597)3.51526938
35acyl-CoA biosynthetic process (GO:0071616)3.49678383
36thioester biosynthetic process (GO:0035384)3.49678383
37regulation of protein activation cascade (GO:2000257)3.46049196
38myelin maintenance (GO:0043217)3.45334695
39indole-containing compound catabolic process (GO:0042436)3.44740114
40indolalkylamine catabolic process (GO:0046218)3.44740114
41tryptophan catabolic process (GO:0006569)3.44740114
42urea metabolic process (GO:0019627)3.40869431
43urea cycle (GO:0000050)3.40869431
44plasma lipoprotein particle clearance (GO:0034381)3.40560445
45glutamate metabolic process (GO:0006536)3.33459476
46aromatic amino acid family metabolic process (GO:0009072)3.30136058
47acetyl-CoA metabolic process (GO:0006084)3.28857266
48reverse cholesterol transport (GO:0043691)3.27156565
49tryptophan metabolic process (GO:0006568)3.24383651
50intestinal cholesterol absorption (GO:0030299)3.23921658
51branching involved in labyrinthine layer morphogenesis (GO:0060670)3.23406257
52ensheathment of neurons (GO:0007272)3.23340399
53axon ensheathment (GO:0008366)3.23340399
54regulation of complement activation (GO:0030449)3.23101811
55regulation of lipoprotein metabolic process (GO:0050746)3.22311656
56cholesterol efflux (GO:0033344)3.21303104
57protein-lipid complex remodeling (GO:0034368)3.21277897
58macromolecular complex remodeling (GO:0034367)3.21277897
59plasma lipoprotein particle remodeling (GO:0034369)3.21277897
60ethanol oxidation (GO:0006069)3.18907705
61myelination (GO:0042552)3.18735956
62regulation of cholesterol esterification (GO:0010872)3.18197401
63triglyceride homeostasis (GO:0070328)3.14469091
64acylglycerol homeostasis (GO:0055090)3.14469091
65iron coordination entity transport (GO:1901678)3.14252890
66thioester metabolic process (GO:0035383)3.13606400
67acyl-CoA metabolic process (GO:0006637)3.13606400
68nitrogen cycle metabolic process (GO:0071941)3.13317556
69cellular ketone body metabolic process (GO:0046950)3.12587010
70positive regulation of lipoprotein lipase activity (GO:0051006)3.10899113
71positive regulation of triglyceride lipase activity (GO:0061365)3.10899113
72alpha-amino acid catabolic process (GO:1901606)3.09585468
73cofactor catabolic process (GO:0051187)3.08665264
74regulation of cholesterol biosynthetic process (GO:0045540)3.07743796
75negative regulation of lipase activity (GO:0060192)3.06666376
76fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.06467983
77short-chain fatty acid metabolic process (GO:0046459)3.05005711
78adhesion of symbiont to host (GO:0044406)3.04646857
79cholesterol metabolic process (GO:0008203)3.04062834
80opsonization (GO:0008228)3.01753744
81regulation of cholesterol metabolic process (GO:0090181)2.97254698
82fat-soluble vitamin biosynthetic process (GO:0042362)2.96727304
83cellular amino acid catabolic process (GO:0009063)2.95303547
84aspartate family amino acid catabolic process (GO:0009068)2.94108626
85epoxygenase P450 pathway (GO:0019373)2.93750755
86cholesterol homeostasis (GO:0042632)2.92742494
87cellular modified amino acid catabolic process (GO:0042219)2.92217141
88sterol homeostasis (GO:0055092)2.88902333
89protein-lipid complex assembly (GO:0065005)2.88202535
90very-low-density lipoprotein particle assembly (GO:0034379)2.88020030
91angiotensin maturation (GO:0002003)2.85981500
92fibrinolysis (GO:0042730)2.85594590
93dicarboxylic acid catabolic process (GO:0043649)2.85391424
94sterol metabolic process (GO:0016125)2.84907033
95homocysteine metabolic process (GO:0050667)2.83503627
96bile acid and bile salt transport (GO:0015721)2.83120473
97linoleic acid metabolic process (GO:0043651)2.82594097
98regulation of bile acid biosynthetic process (GO:0070857)2.82460079
99negative regulation of sterol transport (GO:0032372)2.82256748
100negative regulation of cholesterol transport (GO:0032375)2.82256748
101positive regulation of p38MAPK cascade (GO:1900745)2.82174834
102positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.80189441
103cellular glucuronidation (GO:0052695)2.79763039
104positive regulation of lipid catabolic process (GO:0050996)2.78661309
105regulation of cholesterol storage (GO:0010885)2.77851671
106serine family amino acid catabolic process (GO:0009071)2.77817413
107negative regulation of protein activation cascade (GO:2000258)2.76147527
108regulation of cholesterol homeostasis (GO:2000188)2.75885212
109ethanol metabolic process (GO:0006067)2.75765528
110phospholipid efflux (GO:0033700)2.73943575
111glycosphingolipid catabolic process (GO:0046479)2.71678915
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.66416485
113amyloid precursor protein catabolic process (GO:0042987)2.65453030
114low-density lipoprotein particle clearance (GO:0034383)2.64980614
115regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.63266706
116positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61149980
117vitamin D metabolic process (GO:0042359)2.57245997
118plasma lipoprotein particle assembly (GO:0034377)2.54371346
119L-amino acid import (GO:0043092)2.53972292
120regulation of fever generation (GO:0031620)2.53962164
121regulation of vitamin metabolic process (GO:0030656)2.52049461
122cellular potassium ion homeostasis (GO:0030007)2.51988373
123sodium ion export (GO:0071436)2.50290588
124glycolipid catabolic process (GO:0019377)2.48497002
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.47850971
126positive regulation of cellular amide metabolic process (GO:0034250)2.43093604
127glucocorticoid biosynthetic process (GO:0006704)2.41018231
128regulation of heterotypic cell-cell adhesion (GO:0034114)2.40778251
129positive regulation of steroid metabolic process (GO:0045940)2.39552167
130adhesion of symbiont to host cell (GO:0044650)2.38857694
131virion attachment to host cell (GO:0019062)2.38857694
132regulation of cytokine secretion involved in immune response (GO:0002739)2.38750842
133regulation of vitamin D biosynthetic process (GO:0060556)2.37066850
134positive regulation of heat generation (GO:0031652)2.36329104
135acute-phase response (GO:0006953)2.35640162
136cyclooxygenase pathway (GO:0019371)2.35323876
137regulation of membrane protein ectodomain proteolysis (GO:0051043)2.34822911
138cellular sodium ion homeostasis (GO:0006883)2.31067855
139positive regulation of lipid storage (GO:0010884)2.29443325
140regulation of mononuclear cell migration (GO:0071675)2.29300350
141detection of molecule of bacterial origin (GO:0032490)2.28169020
142lipoprotein transport (GO:0042953)2.24524615
143regulation of podosome assembly (GO:0071801)2.22282477
144cell-cell junction maintenance (GO:0045217)2.21612815
145protein-lipid complex subunit organization (GO:0071825)2.19015578
146activation of MAPKKK activity (GO:0000185)2.18133702
147regulation of p38MAPK cascade (GO:1900744)2.16645672
148epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14711356
149oligosaccharide catabolic process (GO:0009313)2.13970159
150fructose metabolic process (GO:0006000)2.13616983
151exogenous drug catabolic process (GO:0042738)2.13578959
152regulation of NFAT protein import into nucleus (GO:0051532)2.12755981
153cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.11657552
154amino acid import (GO:0043090)2.11382945
155cellular response to cadmium ion (GO:0071276)2.10347012
156glucocorticoid metabolic process (GO:0008211)2.10080347
157negative regulation of lipid transport (GO:0032369)2.08430218
158lipopolysaccharide-mediated signaling pathway (GO:0031663)2.07034290
159ceramide catabolic process (GO:0046514)2.05590379
160positive regulation of steroid biosynthetic process (GO:0010893)2.04958589
161cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.03545060
162hydrogen peroxide biosynthetic process (GO:0050665)2.02464781
163cellular response to thyroid hormone stimulus (GO:0097067)2.01944034
164negative regulation of toll-like receptor signaling pathway (GO:0034122)2.00755089
165cellular response to epinephrine stimulus (GO:0071872)1.99736118
166cell junction maintenance (GO:0034331)1.99558329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.19937630
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.39718104
3* LXR_22158963_ChIP-Seq_LIVER_Mouse3.75987272
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.60298571
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.15347583
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.93003540
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.73309521
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.62457930
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.55627774
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.92123134
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90939217
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89118242
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.82052447
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74996538
15EZH2_22144423_ChIP-Seq_EOC_Human1.71424205
16* CDX2_20551321_ChIP-Seq_CACO-2_Human1.64119745
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.60543234
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59270165
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58359389
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.58215357
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.56860674
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55482494
23KDM2B_26808549_Chip-Seq_K562_Human1.54085250
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53423006
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53415216
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50206988
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48078981
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42175411
29* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41607166
30* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41607166
31AR_21572438_ChIP-Seq_LNCaP_Human1.39997255
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36617087
33GBX2_23144817_ChIP-Seq_PC3_Human1.35925186
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34611890
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34468392
36CLOCK_20551151_ChIP-Seq_293T_Human1.33927891
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33632330
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33158167
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32676729
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29928197
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29928197
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29694180
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26545065
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23209533
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.22873887
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21992292
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20467334
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19994844
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.19733817
50HTT_18923047_ChIP-ChIP_STHdh_Human1.17587314
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.17403187
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17129353
53LXR_22292898_ChIP-Seq_THP-1_Human1.16237033
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16026047
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15676454
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14165499
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13062494
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12974128
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12721948
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12575241
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11877582
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.11543513
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.11482837
64TAF15_26573619_Chip-Seq_HEK293_Human1.08480364
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07512868
66* EP300_21415370_ChIP-Seq_HL-1_Mouse1.07329532
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06725037
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06560844
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06191738
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.05740503
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04333769
72* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03309943
73TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03032112
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.02142477
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.02085564
76AHR_22903824_ChIP-Seq_MCF-7_Human1.01585295
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01454917
78* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01391947
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.99853934
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99298290
81* SOX2_20726797_ChIP-Seq_SW620_Human0.98889102
82NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98885665
83ESR1_21235772_ChIP-Seq_MCF-7_Human0.98433620
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98036124
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97295888
86RING1B_27294783_Chip-Seq_NPCs_Mouse0.96676001
87WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96111176
88* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95872511
89DROSHA_22980978_ChIP-Seq_HELA_Human0.95749376
90PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95064984
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94702379
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94032007
93* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92941032
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92625771
95* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91985370
96DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91047716
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90206869
98* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89875996
99* VDR_24787735_ChIP-Seq_THP-1_Human0.89233230
100* EZH2_27304074_Chip-Seq_ESCs_Mouse0.87410683
101GATA4_25053715_ChIP-Seq_YYC3_Human0.86685943
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86244410
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84428366
104* RNF2_27304074_Chip-Seq_ESCs_Mouse0.84335638
105SMAD3_21741376_ChIP-Seq_EPCs_Human0.84247918
106CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84075650
107HNF4A_19822575_ChIP-Seq_HepG2_Human0.84011207
108TP53_16413492_ChIP-PET_HCT116_Human0.83974845
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83967227
110* SMAD3_21741376_ChIP-Seq_HESCs_Human0.83570953
111TP63_23658742_ChIP-Seq_EP156T_Human0.83268979
112GF1_26923725_Chip-Seq_HPCs_Mouse0.83191237
113ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82923341
114RARB_27405468_Chip-Seq_BRAIN_Mouse0.82326840
115TP53_18474530_ChIP-ChIP_U2OS_Human0.81889698
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81493623
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81455515
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81238693
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80281573
120REST_21632747_ChIP-Seq_MESCs_Mouse0.79865805
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79434115
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79013159
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.78194241
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77472656
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76445901
126* RACK7_27058665_Chip-Seq_MCF-7_Human0.76344287
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76314535
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76227034
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76214722
130* RUNX1_27514584_Chip-Seq_MCF-7_Human0.76204217
131* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.75586251
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75159256
133ISL1_27105846_Chip-Seq_CPCs_Mouse0.74574078
134CJUN_26792858_Chip-Seq_BT549_Human0.74188395
135ZNF263_19887448_ChIP-Seq_K562_Human0.72893799
136ER_23166858_ChIP-Seq_MCF-7_Human0.72422971
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.72191913
138* SMAD4_21741376_ChIP-Seq_HESCs_Human0.71291341
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.71224461
140WT1_19549856_ChIP-ChIP_CCG9911_Human0.71147753
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.70875756
142RXR_22108803_ChIP-Seq_LS180_Human0.70267785
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.70143400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.03835956
2MP0005360_urolithiasis5.21868491
3MP0005085_abnormal_gallbladder_physiolo4.68188963
4MP0005365_abnormal_bile_salt4.25959911
5MP0003303_peritoneal_inflammation4.03204341
6MP0003806_abnormal_nucleotide_metabolis3.58796647
7MP0008875_abnormal_xenobiotic_pharmacok3.52730660
8MP0008004_abnormal_stomach_pH3.29730238
9MP0003252_abnormal_bile_duct2.97904006
10MP0005058_abnormal_lysosome_morphology2.87672355
11MP0003195_calcinosis2.83966885
12MP0005083_abnormal_biliary_tract2.82537872
13MP0000920_abnormal_myelination2.79833356
14MP0010329_abnormal_lipoprotein_level2.57443274
15MP0009840_abnormal_foam_cell2.52481394
16MP0001666_abnormal_nutrient_absorption2.50819350
17MP0003300_gastrointestinal_ulcer2.32355686
18MP0005167_abnormal_blood-brain_barrier2.30377810
19MP0003329_amyloid_beta_deposits2.26510368
20MP0003724_increased_susceptibility_to2.18460766
21MP0006082_CNS_inflammation2.14973676
22MP0005332_abnormal_amino_acid2.05326664
23MP0003690_abnormal_glial_cell2.05154810
24MP0003879_abnormal_hair_cell2.04377112
25MP0003075_altered_response_to2.04202758
26MP0004510_myositis1.96611546
27MP0002118_abnormal_lipid_homeostasis1.94645385
28MP0003183_abnormal_peptide_metabolism1.79647204
29MP0004885_abnormal_endolymph1.76013525
30MP0010678_abnormal_skin_adnexa1.67548216
31MP0000604_amyloidosis1.63623196
32MP0004858_abnormal_nervous_system1.62477659
33MP0003950_abnormal_plasma_membrane1.60929114
34MP0003868_abnormal_feces_composition1.60761922
35MP0005451_abnormal_body_composition1.60153299
36MP0004270_analgesia1.58884316
37MP0001501_abnormal_sleep_pattern1.57498135
38MP0005166_decreased_susceptibility_to1.48825847
39MP0003436_decreased_susceptibility_to1.48312021
40MP0004019_abnormal_vitamin_homeostasis1.45555022
41MP0002998_abnormal_bone_remodeling1.42891006
42MP0003191_abnormal_cellular_cholesterol1.34549146
43MP0000579_abnormal_nail_morphology1.29862321
44MP0000609_abnormal_liver_physiology1.26526987
45MP0005409_darkened_coat_color1.25150398
46MP0005584_abnormal_enzyme/coenzyme_acti1.24585462
47MP0002148_abnormal_hypersensitivity_rea1.23747423
48MP0005076_abnormal_cell_differentiation1.23638223
49MP0002876_abnormal_thyroid_physiology1.22830408
50MP0008438_abnormal_cutaneous_collagen1.21878060
51MP0003011_delayed_dark_adaptation1.20775416
52MP0002796_impaired_skin_barrier1.20489229
53MP0010234_abnormal_vibrissa_follicle1.16896087
54MP0000383_abnormal_hair_follicle1.15809039
55MP0009785_altered_susceptibility_to1.12138956
56MP0003632_abnormal_nervous_system1.09564536
57MP0009764_decreased_sensitivity_to1.08671116
58MP0001533_abnormal_skeleton_physiology1.08463644
59MP0000462_abnormal_digestive_system1.05637902
60MP0005408_hypopigmentation1.04757258
61MP0002332_abnormal_exercise_endurance1.04634667
62MP0003705_abnormal_hypodermis_morpholog1.04621405
63MP0001485_abnormal_pinna_reflex1.02982903
64MP0009384_cardiac_valve_regurgitation1.02412386
65MP0003122_maternal_imprinting1.01347852
66MP0004947_skin_inflammation1.01319401
67MP0003634_abnormal_glial_cell1.00666763
68MP0000566_synostosis0.99806582
69MP0005535_abnormal_body_temperature0.99256438
70MP0002909_abnormal_adrenal_gland0.98831949
71MP0002734_abnormal_mechanical_nocicepti0.98431974
72MP0010155_abnormal_intestine_physiology0.97917427
73MP0004742_abnormal_vestibular_system0.97537242
74MP0004185_abnormal_adipocyte_glucose0.97480211
75MP0002896_abnormal_bone_mineralization0.96365413
76MP0000647_abnormal_sebaceous_gland0.95464720
77MP0009379_abnormal_foot_pigmentation0.95439905
78MP0003656_abnormal_erythrocyte_physiolo0.94643431
79MP0003880_abnormal_central_pattern0.92935704
80MP0009780_abnormal_chondrocyte_physiolo0.92669213
81MP0001486_abnormal_startle_reflex0.92128009
82MP0004381_abnormal_hair_follicle0.92035114
83MP0003172_abnormal_lysosome_physiology0.91818322
84MP0002419_abnormal_innate_immunity0.91124057
85MP0004043_abnormal_pH_regulation0.90197030
86MP0003633_abnormal_nervous_system0.89575548
87MP0003631_nervous_system_phenotype0.89546735
88MP0005319_abnormal_enzyme/_coenzyme0.87837586
89MP0002063_abnormal_learning/memory/cond0.87814983
90MP0001851_eye_inflammation0.86464838
91MP0000343_altered_response_to0.85616191
92MP0005025_abnormal_response_to0.85158436
93MP0005670_abnormal_white_adipose0.84920404
94MP0003453_abnormal_keratinocyte_physiol0.84533966
95MP0000639_abnormal_adrenal_gland0.84477078
96MP0001661_extended_life_span0.82728186
97MP0005023_abnormal_wound_healing0.82669228
98MP0005334_abnormal_fat_pad0.82607546
99MP0005248_abnormal_Harderian_gland0.82008287
100MP0003635_abnormal_synaptic_transmissio0.81106962
101MP0000778_abnormal_nervous_system0.80877221
102MP0008874_decreased_physiological_sensi0.80204073
103MP0005423_abnormal_somatic_nervous0.78896014
104MP0004272_abnormal_basement_membrane0.78805688
105MP0009278_abnormal_bone_marrow0.77483072
106MP0005171_absent_coat_pigmentation0.76743893
107MP0002272_abnormal_nervous_system0.76736386
108MP0001881_abnormal_mammary_gland0.75462460
109MP0004142_abnormal_muscle_tone0.75153498
110MP0008469_abnormal_protein_level0.74858199
111MP0002229_neurodegeneration0.73977287
112MP0002138_abnormal_hepatobiliary_system0.73856215
113MP0004130_abnormal_muscle_cell0.73747429
114MP0002089_abnormal_postnatal_growth/wei0.73588969
115MP0000467_abnormal_esophagus_morphology0.72733728
116MP0002822_catalepsy0.72657788
117MP0003091_abnormal_cell_migration0.72135216
118MP0005647_abnormal_sex_gland0.71539810
119MP0003123_paternal_imprinting0.71536984
120MP0001177_atelectasis0.70189000
121MP0002295_abnormal_pulmonary_circulatio0.69178863
122MP0005164_abnormal_response_to0.68827076
123MP0009643_abnormal_urine_homeostasis0.68435419
124MP0000762_abnormal_tongue_morphology0.67324018
125MP0003448_altered_tumor_morphology0.66649597
126MP0001970_abnormal_pain_threshold0.66218329
127MP0001845_abnormal_inflammatory_respons0.64455245
128MP0001529_abnormal_vocalization0.64264338
129MP0001346_abnormal_lacrimal_gland0.64005887
130MP0005666_abnormal_adipose_tissue0.63150726
131MP0005375_adipose_tissue_phenotype0.63040490
132MP0005448_abnormal_energy_balance0.62791866
133MP0000003_abnormal_adipose_tissue0.62398695
134MP0005275_abnormal_skin_tensile0.61686415
135MP0002971_abnormal_brown_adipose0.61522735
136MP0002064_seizures0.60831332
137MP0000747_muscle_weakness0.60768210
138MP0005623_abnormal_meninges_morphology0.60528273
139MP0000427_abnormal_hair_cycle0.59989923
140MP0002254_reproductive_system_inflammat0.59907242
141MP0009115_abnormal_fat_cell0.59466172
142MP0001764_abnormal_homeostasis0.58831987
143MP0005501_abnormal_skin_physiology0.57061286
144MP0004859_abnormal_synaptic_plasticity0.56624162
145MP0004264_abnormal_extraembryonic_tissu0.56498823
146MP0004134_abnormal_chest_morphology0.56241103
147MP0001340_abnormal_eyelid_morphology0.55976982
148MP0000537_abnormal_urethra_morphology0.55626913
149MP0003186_abnormal_redox_activity0.55482406
150MP0009697_abnormal_copulation0.54996504
151MP0005410_abnormal_fertilization0.54464749
152MP0001440_abnormal_grooming_behavior0.53915066
153MP0000377_abnormal_hair_follicle0.52596370
154MP0009053_abnormal_anal_canal0.52055597
155MP0000955_abnormal_spinal_cord0.51981660
156MP0001299_abnormal_eye_distance/0.51841407

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.75777479
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.69131879
3Deep venous thrombosis (HP:0002625)5.50298076
4Systemic lupus erythematosus (HP:0002725)5.38885526
5Xanthomatosis (HP:0000991)4.92290446
6Neurofibrillary tangles (HP:0002185)4.64503634
7Hyperlipoproteinemia (HP:0010980)4.53597298
8Glomerulonephritis (HP:0000099)4.53504690
9Hypobetalipoproteinemia (HP:0003563)4.37380896
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.26225967
11Prolonged partial thromboplastin time (HP:0003645)4.03873530
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.99708082
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.99708082
14Cerebral inclusion bodies (HP:0100314)3.84701584
15Epidermoid cyst (HP:0200040)3.73758836
16Complement deficiency (HP:0004431)3.51480450
17Abnormality of liposaccharide metabolism (HP:0010968)3.47228695
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.47228695
19Abnormality of glycolipid metabolism (HP:0010969)3.47228695
20Fat malabsorption (HP:0002630)3.41991550
21Abnormality of the corticospinal tract (HP:0002492)3.34806609
22Abnormality of methionine metabolism (HP:0010901)3.30102448
23Hypolipoproteinemia (HP:0010981)3.19726025
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.18135256
25Termporal pattern (HP:0011008)3.08393086
26Insidious onset (HP:0003587)3.08393086
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.08328243
28Hyperammonemia (HP:0001987)3.00644704
29Recurrent gram-negative bacterial infections (HP:0005420)2.98846843
30Parakeratosis (HP:0001036)2.94057820
31Abnormality of sulfur amino acid metabolism (HP:0004339)2.92806518
32Malnutrition (HP:0004395)2.90549959
33Abnormality of the common coagulation pathway (HP:0010990)2.89155631
34Vacuolated lymphocytes (HP:0001922)2.88901742
35Abnormality of serine family amino acid metabolism (HP:0010894)2.86048731
36Abnormality of glycine metabolism (HP:0010895)2.86048731
37Hypophosphatemic rickets (HP:0004912)2.84768431
38Disinhibition (HP:0000734)2.81644825
39Mutism (HP:0002300)2.79156398
40Steatorrhea (HP:0002570)2.78840566
41Nephritis (HP:0000123)2.76814554
42Ketosis (HP:0001946)2.73289819
43Hyperglycinemia (HP:0002154)2.73267805
44Hypoalphalipoproteinemia (HP:0003233)2.70527966
45Action tremor (HP:0002345)2.68406991
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65687643
47Dysostosis multiplex (HP:0000943)2.57140518
48Conjugated hyperbilirubinemia (HP:0002908)2.53118755
49Flat acetabular roof (HP:0003180)2.51559303
50Abnormality of macrophages (HP:0004311)2.46941052
51Vascular calcification (HP:0004934)2.46929056
52Intention tremor (HP:0002080)2.46082894
53Cholecystitis (HP:0001082)2.45155812
54Abnormal gallbladder physiology (HP:0012438)2.45155812
55Turricephaly (HP:0000262)2.43085032
56Neuronal loss in central nervous system (HP:0002529)2.39998555
57Loss of speech (HP:0002371)2.39328098
58Amyloidosis (HP:0011034)2.39164577
59Onion bulb formation (HP:0003383)2.37881351
60Hypercholesterolemia (HP:0003124)2.37076591
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.36026997
62Orchitis (HP:0100796)2.34328929
63Hypoglycemic coma (HP:0001325)2.33615786
64Eczematoid dermatitis (HP:0000976)2.32457253
65Increased cerebral lipofuscin (HP:0011813)2.29646053
66Supranuclear gaze palsy (HP:0000605)2.29563338
67Cardiovascular calcification (HP:0011915)2.28390922
68Joint hemorrhage (HP:0005261)2.27984707
69Abnormality of complement system (HP:0005339)2.26116119
70Coronal craniosynostosis (HP:0004440)2.24381991
71Spastic paraparesis (HP:0002313)2.22632865
72Axonal loss (HP:0003447)2.22452278
73Urinary glycosaminoglycan excretion (HP:0003541)2.20788407
74Mucopolysacchariduria (HP:0008155)2.20788407
75Optic neuritis (HP:0100653)2.18440696
76Retrobulbar optic neuritis (HP:0100654)2.18440696
77Spastic gait (HP:0002064)2.18312981
78Scanning speech (HP:0002168)2.16855293
79Skin nodule (HP:0200036)2.15822222
80Abnormality of polysaccharide metabolism (HP:0011012)2.14739676
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14739676
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14739676
83Abnormal gallbladder morphology (HP:0012437)2.11350843
84Myokymia (HP:0002411)2.11305543
85Abnormality of the distal phalanx of the thumb (HP:0009617)2.09386626
86Abnormality of the periventricular white matter (HP:0002518)2.08553541
87Hyperglycinuria (HP:0003108)2.08462338
88Abnormality of glycolysis (HP:0004366)2.08191543
89Increased serum pyruvate (HP:0003542)2.08191543
90Abnormality of fatty-acid metabolism (HP:0004359)2.08159119
91Rickets (HP:0002748)2.06758258
92Abnormality of the intrinsic pathway (HP:0010989)2.05383560
93Spastic tetraparesis (HP:0001285)2.02294342
94Segmental peripheral demyelination/remyelination (HP:0003481)2.01355351
95Retinal atrophy (HP:0001105)2.00351419
96Hyporeflexia of lower limbs (HP:0002600)2.00291822
97Anomalous pulmonary venous return (HP:0010772)1.99620449
98Congenital ichthyosiform erythroderma (HP:0007431)1.99611818
99Abnormal auditory evoked potentials (HP:0006958)1.99419771
100Hyperparathyroidism (HP:0000843)1.97086182
101Cerebral hemorrhage (HP:0001342)1.97042287
102Osteomalacia (HP:0002749)1.96668285
103Purpura (HP:0000979)1.95122951
104Nuclear cataract (HP:0100018)1.95101822
105Aplasia involving bones of the extremities (HP:0009825)1.93467577
106Aplasia involving bones of the upper limbs (HP:0009823)1.93467577
107Aplasia of the phalanges of the hand (HP:0009802)1.93467577
108Ankle clonus (HP:0011448)1.93093733
109Ileus (HP:0002595)1.92194167
110Peripheral hypomyelination (HP:0007182)1.91590478
111Hepatocellular carcinoma (HP:0001402)1.91205082
112Morphological abnormality of the pyramidal tract (HP:0002062)1.90989207
113Sensory axonal neuropathy (HP:0003390)1.90871349
114Abnormality of the Achilles tendon (HP:0005109)1.90204566
115Peripheral demyelination (HP:0011096)1.89231491
116Spontaneous abortion (HP:0005268)1.88532269
117Widely patent fontanelles and sutures (HP:0004492)1.87598101
118Apathy (HP:0000741)1.86576099
119Hyperbilirubinemia (HP:0002904)1.86416993
120Cholelithiasis (HP:0001081)1.85886983
121Split foot (HP:0001839)1.85756152
122Delayed CNS myelination (HP:0002188)1.85104110
123Methylmalonic acidemia (HP:0002912)1.84898724
124Paraparesis (HP:0002385)1.84642284
125Autoamputation (HP:0001218)1.83926069
126Bronchomalacia (HP:0002780)1.83342467
127Infantile muscular hypotonia (HP:0008947)1.81947217
128Dementia (HP:0000726)1.81291143
129Abnormality of carpal bone ossification (HP:0006257)1.81251357
130Glomerulosclerosis (HP:0000096)1.80847991
131Acanthocytosis (HP:0001927)1.80817473
132Irritability (HP:0000737)1.80651783
133Myocardial infarction (HP:0001658)1.79118303
134Abnormality of vitamin metabolism (HP:0100508)1.78829995
135Confusion (HP:0001289)1.76974938
136Abnormality of serum amino acid levels (HP:0003112)1.76363249
137Gingivitis (HP:0000230)1.76202628
138Urinary incontinence (HP:0000020)1.74580323
139Back pain (HP:0003418)1.73266751
140Focal segmental glomerulosclerosis (HP:0000097)1.73038600
141Dysmetria (HP:0001310)1.72988465
142Stridor (HP:0010307)1.72445175
143Diminished motivation (HP:0000745)1.71779822
144Enlarged kidneys (HP:0000105)1.71055081
145Muscle fiber splitting (HP:0003555)1.70378264
146Joint swelling (HP:0001386)1.69804057
147Abnormality of the pulmonary veins (HP:0011718)1.69767241
148Hypophosphatemia (HP:0002148)1.69687191
149Ketoacidosis (HP:0001993)1.69494013
150Bone pain (HP:0002653)1.68901550
151Sensorimotor neuropathy (HP:0007141)1.68603601
152Thin bony cortex (HP:0002753)1.68470567
153Renal tubular acidosis (HP:0001947)1.68237626
154Protuberant abdomen (HP:0001538)1.67576409
155Brushfield spots (HP:0001088)1.67289131
156Acne (HP:0001061)1.67252740
157Abnormality of the gallbladder (HP:0005264)1.65984774
158Abnormal ossification of hand bones (HP:0005921)1.65502159
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65293096
160Mitral stenosis (HP:0001718)1.64801806
161Lethargy (HP:0001254)1.64738504
162Partial duplication of thumb phalanx (HP:0009944)1.63944405
163Cupped ribs (HP:0000887)1.63782256
164Inappropriate behavior (HP:0000719)1.63564721
165Mixed hearing impairment (HP:0000410)1.62193110
166Abnormality of the parietal bone (HP:0002696)1.61454315
167Metaphyseal irregularity (HP:0003025)1.61249722
168Recurrent bacterial skin infections (HP:0005406)1.59873476
169Hemorrhage of the eye (HP:0011885)1.59727698
170Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.59374242
171Myositis (HP:0100614)1.58341674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.13853774
2RIPK14.07575237
3EPHB13.77595294
4PRPF4B2.95194762
5OXSR12.93164525
6FGFR22.67421130
7MET2.60197189
8BCKDK2.34019665
9WNK42.17019042
10PKN12.16957860
11IRAK32.14880566
12MAPKAPK52.11461387
13LATS12.00264033
14SIK11.97519786
15NTRK31.95172843
16BCR1.92411658
17NTRK11.89573130
18LIMK11.80725583
19AKT31.64103130
20PBK1.63808877
21TAOK21.61124415
22WNK11.59915047
23MAP3K111.54043649
24ERBB41.43625895
25MST1R1.40642918
26MAP3K21.36970967
27TAOK11.36429921
28CSNK1A1L1.36331376
29SGK21.35764004
30NTRK21.32968200
31CDC42BPA1.32671688
32PAK31.29351932
33MATK1.28992627
34CSNK1G31.26297134
35PDGFRA1.25227891
36CAMK2B1.24071240
37FGFR41.22554567
38SGK4941.22250545
39SGK2231.22250545
40KSR21.21929500
41CSNK1G21.18751542
42CAMK2G1.16409193
43ROCK21.15565146
44SGK31.15208193
45CSNK1G11.14339386
46TESK21.12745319
47DDR21.12711705
48RIPK41.11942716
49FER1.10989789
50PAK61.10854584
51ERN11.10167757
52MAP2K41.09386628
53DAPK21.07663694
54EPHA41.05222174
55CSK1.04218246
56UHMK11.03551367
57TYRO31.01455490
58MAP2K21.01226727
59CAMK2D1.01212504
60PIK3CA0.99980451
61MARK10.98713981
62GRK70.98327333
63INSRR0.97133598
64CAMK1G0.97030226
65PTK20.96855550
66FGFR30.96197802
67LATS20.93879454
68ICK0.93875992
69PDK20.93105353
70TRIB30.91045930
71PTK60.90707774
72JAK20.89924468
73JAK10.89322176
74TNIK0.89199740
75PDPK10.87304105
76PHKG20.86359636
77PHKG10.86359636
78ERBB20.86057155
79GSK3A0.84546446
80PRKD10.84344289
81TYK20.84244093
82EPHA20.83703425
83RET0.83614614
84MINK10.82573461
85FGR0.82427994
86PNCK0.82309046
87PIK3CG0.82233645
88DYRK1B0.77329231
89BLK0.74021644
90BMX0.73788307
91PDK10.73364442
92MAP3K70.72662741
93CAMK2A0.72621028
94MAP3K140.72484010
95FRK0.72453695
96CDK190.70781092
97MAP3K90.70433662
98TBK10.67560886
99PRKCZ0.66802012
100DYRK20.66469650
101SGK10.65336509
102CAMK40.65171208
103MAP3K30.64811227
104CAMKK10.64266083
105MAP2K10.63387790
106PRKCE0.62815756
107MAPK120.60787983
108PRKCQ0.60426159
109MAP3K50.60415885
110ABL20.60023562
111DMPK0.59883559
112CDK50.59440632
113NEK60.58298019
114PRKAA20.56520692
115NLK0.56424257
116EPHB20.55661383
117ACVR1B0.55211086
118MARK20.54841571
119STK38L0.54545261
120CDK140.53846714
121CAMK1D0.53607956
122MAP3K120.52708973
123BMPR20.52575626
124TGFBR20.51572341
125PRKD30.51108103
126CHUK0.50889974
127KSR10.50662224
128MAPK70.49816843
129CASK0.49503188
130STK380.49257532
131MOS0.49155452
132MUSK0.48968322
133IRAK20.48687208
134PRKACG0.48452456
135MAPK150.47496162
136FGFR10.47417090
137MAP3K10.46801530
138MAP2K30.46110873
139MAPK100.45424961
140MTOR0.45349917
141EPHA30.45093537
142PAK20.44988190
143RPS6KA20.44904416
144CDK150.44520933
145PDGFRB0.44347329
146PRKG10.44205207
147ZAP700.44126238
148FYN0.43995762
149CSNK1D0.43803249
150TRPM70.43436308
151LRRK20.43183351
152DAPK30.42975863
153TAOK30.42483189
154MAP3K40.41641330
155PRKACB0.40484390

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.35017405
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.35452552
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.31119777
4Steroid biosynthesis_Homo sapiens_hsa001002.98506778
5Fatty acid elongation_Homo sapiens_hsa000622.73383527
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51380496
7Arginine biosynthesis_Homo sapiens_hsa002202.40495701
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.39689297
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33711139
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28961531
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22977378
12Butanoate metabolism_Homo sapiens_hsa006502.22527068
13Histidine metabolism_Homo sapiens_hsa003402.19810622
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02442337
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98541486
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94722270
17Tryptophan metabolism_Homo sapiens_hsa003801.93123295
18Complement and coagulation cascades_Homo sapiens_hsa046101.92796824
19Fatty acid degradation_Homo sapiens_hsa000711.92387457
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91674406
21Sulfur metabolism_Homo sapiens_hsa009201.89970651
22Fatty acid metabolism_Homo sapiens_hsa012121.86326076
23Propanoate metabolism_Homo sapiens_hsa006401.83379803
24Other glycan degradation_Homo sapiens_hsa005111.76076372
25Peroxisome_Homo sapiens_hsa041461.71654996
26PPAR signaling pathway_Homo sapiens_hsa033201.63753946
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62139482
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60858039
29Chemical carcinogenesis_Homo sapiens_hsa052041.60368466
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.55927257
31Fat digestion and absorption_Homo sapiens_hsa049751.43346220
32Caffeine metabolism_Homo sapiens_hsa002321.41241435
33Retinol metabolism_Homo sapiens_hsa008301.39136675
34Bile secretion_Homo sapiens_hsa049761.37883941
35beta-Alanine metabolism_Homo sapiens_hsa004101.36500655
36Pertussis_Homo sapiens_hsa051331.33877428
37Tyrosine metabolism_Homo sapiens_hsa003501.30901898
38Pyruvate metabolism_Homo sapiens_hsa006201.29145334
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24482197
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23933282
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20834504
42Vitamin B6 metabolism_Homo sapiens_hsa007501.19834414
43Osteoclast differentiation_Homo sapiens_hsa043801.16683410
44Phenylalanine metabolism_Homo sapiens_hsa003601.13518842
45Fatty acid biosynthesis_Homo sapiens_hsa000611.11226491
46Lysosome_Homo sapiens_hsa041421.09561503
47Arginine and proline metabolism_Homo sapiens_hsa003301.09399136
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07959763
49Ether lipid metabolism_Homo sapiens_hsa005651.05205216
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.04628323
51TNF signaling pathway_Homo sapiens_hsa046681.01724499
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01030323
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00833005
54Renin-angiotensin system_Homo sapiens_hsa046141.00153656
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98110567
56Staphylococcus aureus infection_Homo sapiens_hsa051500.96583597
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94754159
58Folate biosynthesis_Homo sapiens_hsa007900.92010651
59Linoleic acid metabolism_Homo sapiens_hsa005910.90092852
60Vitamin digestion and absorption_Homo sapiens_hsa049770.89297022
61Salmonella infection_Homo sapiens_hsa051320.89152373
62ABC transporters_Homo sapiens_hsa020100.88726319
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88545482
64African trypanosomiasis_Homo sapiens_hsa051430.86457361
65Starch and sucrose metabolism_Homo sapiens_hsa005000.86314057
66Synaptic vesicle cycle_Homo sapiens_hsa047210.84779965
67Hepatitis C_Homo sapiens_hsa051600.79360538
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78673229
69Leishmaniasis_Homo sapiens_hsa051400.78392770
70Glycerolipid metabolism_Homo sapiens_hsa005610.77533654
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77319369
72Malaria_Homo sapiens_hsa051440.75059578
73Type II diabetes mellitus_Homo sapiens_hsa049300.74850815
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.73995309
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73100121
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.73077665
77Glutathione metabolism_Homo sapiens_hsa004800.72737928
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70896335
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70825332
80Rheumatoid arthritis_Homo sapiens_hsa053230.70364070
81Prolactin signaling pathway_Homo sapiens_hsa049170.69810548
82Biosynthesis of amino acids_Homo sapiens_hsa012300.68569563
83Galactose metabolism_Homo sapiens_hsa000520.67547444
84GnRH signaling pathway_Homo sapiens_hsa049120.67526954
85Carbon metabolism_Homo sapiens_hsa012000.67100163
86Tuberculosis_Homo sapiens_hsa051520.66863538
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.65125017
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64305262
89Selenocompound metabolism_Homo sapiens_hsa004500.62885485
90VEGF signaling pathway_Homo sapiens_hsa043700.58197168
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57977515
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54830879
93Fructose and mannose metabolism_Homo sapiens_hsa000510.50550774
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.50303434
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49951859
96Collecting duct acid secretion_Homo sapiens_hsa049660.49497280
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.49364457
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48833991
99ErbB signaling pathway_Homo sapiens_hsa040120.48785848
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.47782698
101Long-term potentiation_Homo sapiens_hsa047200.47586001
102Chemokine signaling pathway_Homo sapiens_hsa040620.47428715
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46820591
104Insulin signaling pathway_Homo sapiens_hsa049100.46633091
105Vibrio cholerae infection_Homo sapiens_hsa051100.45732541
106Choline metabolism in cancer_Homo sapiens_hsa052310.45424482
107Legionellosis_Homo sapiens_hsa051340.45327849
108Phagosome_Homo sapiens_hsa041450.45068230
109Renin secretion_Homo sapiens_hsa049240.45062392
110Notch signaling pathway_Homo sapiens_hsa043300.44934275
111Axon guidance_Homo sapiens_hsa043600.44779074
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.42492600
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.42482954
114Estrogen signaling pathway_Homo sapiens_hsa049150.41668409
115Lysine degradation_Homo sapiens_hsa003100.41608618
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41245728
117Prion diseases_Homo sapiens_hsa050200.40554084
118HIF-1 signaling pathway_Homo sapiens_hsa040660.39259051
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39089191
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38565222
121Metabolic pathways_Homo sapiens_hsa011000.38041541
122Tight junction_Homo sapiens_hsa045300.37073630
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.37054421
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35557426
125Sulfur relay system_Homo sapiens_hsa041220.33602607
126Mineral absorption_Homo sapiens_hsa049780.27707296
127Ovarian steroidogenesis_Homo sapiens_hsa049130.27302739
128GABAergic synapse_Homo sapiens_hsa047270.23787213
129Pancreatic secretion_Homo sapiens_hsa049720.22361412
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19581130
131Sphingolipid metabolism_Homo sapiens_hsa006000.19367580
132Renal cell carcinoma_Homo sapiens_hsa052110.18675349
133Thyroid hormone synthesis_Homo sapiens_hsa049180.17163481
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15094932
135Arachidonic acid metabolism_Homo sapiens_hsa005900.14654213
136Protein digestion and absorption_Homo sapiens_hsa049740.13861291
137Pentose phosphate pathway_Homo sapiens_hsa000300.13565377
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12995713
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.12725814
140Glutamatergic synapse_Homo sapiens_hsa047240.12710358
141ECM-receptor interaction_Homo sapiens_hsa045120.10466205
142Protein export_Homo sapiens_hsa030600.09449551
143Dorso-ventral axis formation_Homo sapiens_hsa043200.09177009
144AMPK signaling pathway_Homo sapiens_hsa041520.08484028
145Amoebiasis_Homo sapiens_hsa051460.07627086
146Insulin resistance_Homo sapiens_hsa049310.07455919
147Cocaine addiction_Homo sapiens_hsa050300.07440619
148Long-term depression_Homo sapiens_hsa047300.07180778
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.06789140
150Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05506987
151Gastric acid secretion_Homo sapiens_hsa049710.05337665
152Salivary secretion_Homo sapiens_hsa049700.04063773

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