RHOXF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the PEPP subfamily of paired-like homoebox genes. The gene may be regulated by androgens and epigenetic mechanisms. The encoded nuclear protein is likely a transcription factor that may play a role in human reproduction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)7.93888025
2tyrosine phosphorylation of STAT protein (GO:0007260)7.34034988
3synaptonemal complex assembly (GO:0007130)7.07306953
4acrosome assembly (GO:0001675)6.38610142
5sequestering of actin monomers (GO:0042989)6.20628544
6synaptonemal complex organization (GO:0070193)6.17697150
7male meiosis I (GO:0007141)5.82759445
8positive regulation of mitochondrial fission (GO:0090141)5.82265828
9chromosome organization involved in meiosis (GO:0070192)5.73606618
10positive regulation of protein homooligomerization (GO:0032464)5.69824847
11male meiosis (GO:0007140)5.36237132
12synapsis (GO:0007129)5.02778317
13behavioral response to nicotine (GO:0035095)4.76711478
14glyoxylate metabolic process (GO:0046487)4.75055188
15pyrimidine dimer repair (GO:0006290)4.70706412
16parturition (GO:0007567)4.70108047
17dopamine biosynthetic process (GO:0042416)4.58204208
18sex differentiation (GO:0007548)4.38469855
19resolution of meiotic recombination intermediates (GO:0000712)4.35336575
20axoneme assembly (GO:0035082)4.29389943
21meiosis I (GO:0007127)4.17876767
22intraciliary transport (GO:0042073)3.97311163
23negative regulation of circadian rhythm (GO:0042754)3.93034270
24left/right pattern formation (GO:0060972)3.91890703
25seminiferous tubule development (GO:0072520)3.78373187
26meiotic nuclear division (GO:0007126)3.76306239
27purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.74139166
28gonadal mesoderm development (GO:0007506)3.71113339
29cilium or flagellum-dependent cell motility (GO:0001539)3.70142583
30regulation of glucocorticoid secretion (GO:2000849)3.69123491
31regulation of mitochondrial fission (GO:0090140)3.67863331
32epithelial cilium movement (GO:0003351)3.66188552
33anatomical structure regression (GO:0060033)3.65316502
34substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.55918896
35substrate-independent telencephalic tangential migration (GO:0021826)3.55918896
36chaperone-mediated protein transport (GO:0072321)3.55712224
37neuronal ion channel clustering (GO:0045161)3.54789918
38cilium movement (GO:0003341)3.54567315
39SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.53612096
40activated T cell proliferation (GO:0050798)3.53218996
41regulation of cilium movement (GO:0003352)3.47646599
42dopamine transport (GO:0015872)3.46236162
43serotonin receptor signaling pathway (GO:0007210)3.39205142
44DNA methylation (GO:0006306)3.33078576
45DNA alkylation (GO:0006305)3.33078576
46regulation of protein homooligomerization (GO:0032462)3.26049299
47meiotic cell cycle process (GO:1903046)3.20817857
48exploration behavior (GO:0035640)3.19918429
49ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.19787664
50viral transcription (GO:0019083)3.19065557
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.17630298
52central nervous system myelination (GO:0022010)3.07017692
53axon ensheathment in central nervous system (GO:0032291)3.07017692
54regulation of gonadotropin secretion (GO:0032276)3.06947056
55potassium ion export (GO:0071435)3.06185744
56regulation of microtubule-based movement (GO:0060632)3.05016461
57positive regulation of dendritic spine morphogenesis (GO:0061003)3.05004273
58meiotic chromosome segregation (GO:0045132)3.04391502
59regulation of dopamine metabolic process (GO:0042053)3.02841332
60regulation of catecholamine metabolic process (GO:0042069)3.02841332
61locomotory exploration behavior (GO:0035641)3.02524313
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02384525
63ribosomal small subunit assembly (GO:0000028)3.01008073
64catecholamine biosynthetic process (GO:0042423)2.99879049
65catechol-containing compound biosynthetic process (GO:0009713)2.99879049
66protein complex biogenesis (GO:0070271)2.98881280
67regulation of corticosteroid hormone secretion (GO:2000846)2.97935416
68translational termination (GO:0006415)2.93805972
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92772563
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.92772563
71NADH dehydrogenase complex assembly (GO:0010257)2.92772563
72histone H3-K9 demethylation (GO:0033169)2.92196561
73tongue development (GO:0043586)2.89105650
74embryonic body morphogenesis (GO:0010172)2.88668813
75entrainment of circadian clock by photoperiod (GO:0043153)2.88047050
76detection of temperature stimulus involved in sensory perception (GO:0050961)2.87798480
77detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.87798480
78energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87597238
79ATP synthesis coupled proton transport (GO:0015986)2.87597238
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86120481
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86120481
82body morphogenesis (GO:0010171)2.84622812
83mitochondrion degradation (GO:0000422)2.83224166
84synaptic transmission, dopaminergic (GO:0001963)2.82482438
85short-term memory (GO:0007614)2.80695301
86glycerophospholipid catabolic process (GO:0046475)2.79788964
87protein localization to cilium (GO:0061512)2.78271051
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77592337
89establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77393913
90mitochondrion transport along microtubule (GO:0047497)2.77393913
91positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77350214
92negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.75522424
93establishment of mitochondrion localization (GO:0051654)2.75154928
94regulation of meiosis I (GO:0060631)2.73534067
95mitochondrial fusion (GO:0008053)2.73264164
96regulation of sequestering of triglyceride (GO:0010889)2.73081751
97microtubule bundle formation (GO:0001578)2.70327647
98maturation of SSU-rRNA (GO:0030490)2.69590051
99serine family amino acid catabolic process (GO:0009071)2.67802239
100piRNA metabolic process (GO:0034587)10.6028144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.26243290
2EZH2_22144423_ChIP-Seq_EOC_Human6.74501542
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.59096187
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.21893344
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.91453510
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.84567235
7IGF1R_20145208_ChIP-Seq_DFB_Human2.63764176
8VDR_22108803_ChIP-Seq_LS180_Human2.45768540
9TAF15_26573619_Chip-Seq_HEK293_Human2.24805813
10RNF2_27304074_Chip-Seq_NSC_Mouse2.22512989
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20579278
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.19261472
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12936320
14REST_21632747_ChIP-Seq_MESCs_Mouse2.06445260
15IRF1_19129219_ChIP-ChIP_H3396_Human1.94753998
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91233825
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84286285
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.83436500
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.81984041
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81927238
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79439179
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65498150
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56458685
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56458685
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.49471350
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.47410342
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.45962404
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41307122
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39524295
30SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38935984
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37401515
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37011229
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35712953
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34852318
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34643750
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.33918169
37CTCF_27219007_Chip-Seq_Bcells_Human1.32247937
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.30500655
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28693889
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26880606
41ZNF274_21170338_ChIP-Seq_K562_Hela1.24942752
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24536106
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17618992
44SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17604761
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16756826
46SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16315476
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14578289
48RUNX2_22187159_ChIP-Seq_PCA_Human1.11208323
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09267735
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09267735
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08316747
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07897769
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07745271
54E2F1_17053090_ChIP-ChIP_MCF-7_Human1.06481068
55SOX11_22085726_ChIP-Seq_ESNs_Mouse1.06412245
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05101739
57PHF8_20622854_ChIP-Seq_HELA_Human1.04879907
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04246347
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01569262
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99149708
61NCOR_22424771_ChIP-Seq_293T_Human0.98951719
62WDR5_24793694_ChIP-Seq_LNCAP_Human0.98718961
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97557287
64CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96485708
65GABP_17652178_ChIP-ChIP_JURKAT_Human0.95303281
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94784340
67JUN_21703547_ChIP-Seq_K562_Human0.93950496
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93548552
69TP53_22573176_ChIP-Seq_HFKS_Human0.92296536
70YY1_21170310_ChIP-Seq_MESCs_Mouse0.90979504
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90705933
72DROSHA_22980978_ChIP-Seq_HELA_Human0.89941386
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89899151
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89779287
75SOX2_21211035_ChIP-Seq_LN229_Human0.89677276
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87886612
77REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87649850
78SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86901087
79LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85305915
80ERA_21632823_ChIP-Seq_H3396_Human0.84206005
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82839062
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82803140
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82242740
84RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82097358
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82069844
86P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79738458
87BCL6_27268052_Chip-Seq_Bcells_Human0.79051425
88MYC_18940864_ChIP-ChIP_HL60_Human0.79043665
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78597491
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78183394
91P68_20966046_ChIP-Seq_HELA_Human0.77897922
92ETS1_20019798_ChIP-Seq_JURKAT_Human0.77822655
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.77236867
94CTCF_20526341_ChIP-Seq_ESCs_Human0.76514346
95ER_23166858_ChIP-Seq_MCF-7_Human0.75232797
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75057204
97RARB_27405468_Chip-Seq_BRAIN_Mouse0.74379205
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74247760
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73852661
100P300_19829295_ChIP-Seq_ESCs_Human0.73589000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.43233497
2MP0003880_abnormal_central_pattern5.22792990
3MP0002653_abnormal_ependyma_morphology3.44649875
4MP0005423_abnormal_somatic_nervous3.37338055
5MP0008995_early_reproductive_senescence3.25322645
6MP0006276_abnormal_autonomic_nervous3.19456777
7MP0002638_abnormal_pupillary_reflex2.98639590
8MP0002160_abnormal_reproductive_system2.80354406
9MP0003123_paternal_imprinting2.79522762
10MP0003787_abnormal_imprinting2.39962891
11MP0006292_abnormal_olfactory_placode2.33065201
12MP0009379_abnormal_foot_pigmentation2.31962991
13MP0002210_abnormal_sex_determination2.21068714
14MP0003011_delayed_dark_adaptation2.19799696
15MP0002736_abnormal_nociception_after2.17710245
16MP0008789_abnormal_olfactory_epithelium1.91876671
17MP0000778_abnormal_nervous_system1.81647440
18MP0005394_taste/olfaction_phenotype1.76766249
19MP0005499_abnormal_olfactory_system1.76766249
20MP0003121_genomic_imprinting1.76284889
21MP0002139_abnormal_hepatobiliary_system1.75775832
22MP0001905_abnormal_dopamine_level1.71573873
23MP0003122_maternal_imprinting1.69188403
24MP0001502_abnormal_circadian_rhythm1.69086250
25MP0001145_abnormal_male_reproductive1.68539594
26MP0001929_abnormal_gametogenesis1.66277696
27MP0000566_synostosis1.63667261
28MP0001188_hyperpigmentation1.58336031
29MP0004145_abnormal_muscle_electrophysio1.58319914
30MP0000653_abnormal_sex_gland1.57435060
31MP0001529_abnormal_vocalization1.56420922
32MP0003698_abnormal_male_reproductive1.52906904
33MP0005389_reproductive_system_phenotype1.50142212
34MP0001968_abnormal_touch/_nociception1.47969635
35MP0003635_abnormal_synaptic_transmissio1.37454442
36MP0005083_abnormal_biliary_tract1.36381987
37MP0001727_abnormal_embryo_implantation1.33578699
38MP0004859_abnormal_synaptic_plasticity1.30796922
39MP0003890_abnormal_embryonic-extraembry1.26113377
40MP0005377_hearing/vestibular/ear_phenot1.24806093
41MP0003878_abnormal_ear_physiology1.24806093
42MP0005084_abnormal_gallbladder_morpholo1.24117411
43MP0000955_abnormal_spinal_cord1.23265909
44MP0009745_abnormal_behavioral_response1.20524253
45MP0004885_abnormal_endolymph1.19910168
46MP0002063_abnormal_learning/memory/cond1.19301239
47MP0002184_abnormal_innervation1.18244067
48MP0003186_abnormal_redox_activity1.15787145
49MP0002822_catalepsy1.15068529
50MP0004142_abnormal_muscle_tone1.13847663
51MP0008058_abnormal_DNA_repair1.10511140
52MP0002557_abnormal_social/conspecific_i1.08289331
53MP0003567_abnormal_fetal_cardiomyocyte1.07085975
54MP0001485_abnormal_pinna_reflex1.06466544
55MP0002272_abnormal_nervous_system1.03902391
56MP0001440_abnormal_grooming_behavior1.03744539
57MP0005551_abnormal_eye_electrophysiolog1.02468956
58MP0001119_abnormal_female_reproductive1.00994443
59MP0002909_abnormal_adrenal_gland1.00157921
60MP0005360_urolithiasis0.99500676
61MP0002064_seizures0.96610218
62MP0009046_muscle_twitch0.94561285
63MP0002572_abnormal_emotion/affect_behav0.94297212
64MP0005253_abnormal_eye_physiology0.93705790
65MP0002882_abnormal_neuron_morphology0.93050300
66MP0002876_abnormal_thyroid_physiology0.92091022
67MP0005075_abnormal_melanosome_morpholog0.90741134
68MP0002751_abnormal_autonomic_nervous0.88021703
69MP0003936_abnormal_reproductive_system0.87972033
70MP0002733_abnormal_thermal_nociception0.87284964
71MP0008004_abnormal_stomach_pH0.86650975
72MP0002161_abnormal_fertility/fecundity0.86045949
73MP0002752_abnormal_somatic_nervous0.85313120
74MP0000631_abnormal_neuroendocrine_gland0.84637402
75MP0001666_abnormal_nutrient_absorption0.83966302
76MP0002734_abnormal_mechanical_nocicepti0.80700222
77MP0001986_abnormal_taste_sensitivity0.80308883
78MP0004134_abnormal_chest_morphology0.80269201
79MP0006072_abnormal_retinal_apoptosis0.80097492
80MP0004811_abnormal_neuron_physiology0.79860974
81MP0003786_premature_aging0.77341816
82MP0003699_abnormal_female_reproductive0.74062714
83MP0002067_abnormal_sensory_capabilities0.73922927
84MP0004133_heterotaxia0.72027298
85MP0002233_abnormal_nose_morphology0.71708868
86MP0006036_abnormal_mitochondrial_physio0.71649435
87MP0000013_abnormal_adipose_tissue0.71485196
88MP0003942_abnormal_urinary_system0.71272059
89MP0005535_abnormal_body_temperature0.70647651
90MP0000639_abnormal_adrenal_gland0.70245590
91MP0002938_white_spotting0.70085188
92MP0001984_abnormal_olfaction0.69527903
93MP0005220_abnormal_exocrine_pancreas0.69283649
94MP0002152_abnormal_brain_morphology0.67817433
95MP0003948_abnormal_gas_homeostasis0.65281085
96MP0000678_abnormal_parathyroid_gland0.64939511
97MP0001293_anophthalmia0.64770727
98MP0002928_abnormal_bile_duct0.64585585
99MP0002229_neurodegeneration0.63007123
100MP0005195_abnormal_posterior_eye0.61657966

Predicted human phenotypes

RankGene SetZ-score
1Gonadotropin excess (HP:0000837)5.46856309
2Menstrual irregularities (HP:0000858)4.55999063
3Tubulointerstitial nephritis (HP:0001970)4.25255105
4Myokymia (HP:0002411)4.21218342
5Amyotrophic lateral sclerosis (HP:0007354)4.14023024
6Osteomalacia (HP:0002749)3.76327493
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.69363584
8Supranuclear gaze palsy (HP:0000605)3.58952652
9Male infertility (HP:0003251)3.51283204
10Limb dystonia (HP:0002451)3.47762612
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.40595597
12Proximal tubulopathy (HP:0000114)3.36089267
13Renal Fanconi syndrome (HP:0001994)3.33006779
14Abnormality of the lower motor neuron (HP:0002366)3.16093871
15Abnormal respiratory motile cilium physiology (HP:0012261)3.14048772
16Infertility (HP:0000789)3.02534880
17Abnormal pancreas size (HP:0012094)3.01771268
18Medial flaring of the eyebrow (HP:0010747)2.95793192
19Papilledema (HP:0001085)2.82765871
20Hyperpituitarism (HP:0010514)2.82491446
21Abnormality of cochlea (HP:0000375)2.79854628
22Hypercholesterolemia (HP:0003124)2.71680764
23Gait imbalance (HP:0002141)2.70278013
24Abnormal respiratory epithelium morphology (HP:0012253)2.69175426
25Abnormal respiratory motile cilium morphology (HP:0005938)2.69175426
26Abnormality of the corticospinal tract (HP:0002492)2.65679260
27Polyphagia (HP:0002591)2.64977519
28Atrophy/Degeneration involving motor neurons (HP:0007373)2.64504346
29Abnormal ciliary motility (HP:0012262)2.62778157
30Stenosis of the external auditory canal (HP:0000402)2.61694383
31Renal dysplasia (HP:0000110)2.56894655
32Hepatocellular necrosis (HP:0001404)2.56223627
33Long foot (HP:0001833)2.54943954
34Thoracolumbar scoliosis (HP:0002944)2.53518198
35Rhinitis (HP:0012384)2.51553227
36Congenital primary aphakia (HP:0007707)2.51093445
37Increased CSF lactate (HP:0002490)2.50448782
38Reticulocytopenia (HP:0001896)2.47682603
39Abnormal mitochondria in muscle tissue (HP:0008316)2.47194260
40Hyperglycinemia (HP:0002154)2.43734271
41Chronic hepatic failure (HP:0100626)2.43431873
42Mitochondrial inheritance (HP:0001427)2.36336997
43Hyperphosphaturia (HP:0003109)2.35535764
44Abnormality of renal resorption (HP:0011038)2.33770537
45Abnormality of the renal medulla (HP:0100957)2.32428235
46Growth hormone excess (HP:0000845)2.31463314
47Acute necrotizing encephalopathy (HP:0006965)2.30835590
48Nephrogenic diabetes insipidus (HP:0009806)2.30784710
49Increased intramyocellular lipid droplets (HP:0012240)2.30091031
50Oligomenorrhea (HP:0000876)2.27642774
51Agitation (HP:0000713)2.23714146
52Tubulointerstitial abnormality (HP:0001969)2.17058112
53Absent/shortened dynein arms (HP:0200106)2.14560180
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.14560180
55Renal cortical cysts (HP:0000803)2.13817005
56Hepatic necrosis (HP:0002605)2.13334696
57Male pseudohermaphroditism (HP:0000037)2.12641405
58Increased hepatocellular lipid droplets (HP:0006565)2.12475691
59CNS hypomyelination (HP:0003429)2.11676472
60Increased muscle lipid content (HP:0009058)2.10014311
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08923886
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08923886
63Abnormal urine phosphate concentration (HP:0012599)2.05390418
64Focal motor seizures (HP:0011153)2.05325767
65Bony spicule pigmentary retinopathy (HP:0007737)2.04081917
66Nephronophthisis (HP:0000090)2.02874700
67Anosmia (HP:0000458)2.02471052
68Acute encephalopathy (HP:0006846)2.01293749
69Preauricular pit (HP:0004467)2.01147327
70Periauricular skin pits (HP:0100277)2.01147327
71Enlarged kidneys (HP:0000105)2.00281851
72Postural instability (HP:0002172)1.98814672
73Poor coordination (HP:0002370)1.98108751
74Abnormal eating behavior (HP:0100738)1.97909402
75Abnormal rod and cone electroretinograms (HP:0008323)1.97160576
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96647817
77Degeneration of the lateral corticospinal tracts (HP:0002314)1.96647817
78Morphological abnormality of the inner ear (HP:0011390)1.96606079
79Cerebral hypomyelination (HP:0006808)1.96214968
80Chronic bronchitis (HP:0004469)1.95387869
81Genital tract atresia (HP:0001827)1.92706952
82Diastasis recti (HP:0001540)1.92542625
83Broad foot (HP:0001769)1.91064271
84Pallor (HP:0000980)1.89569471
85Morphological abnormality of the pyramidal tract (HP:0002062)1.89180247
86Shoulder girdle muscle weakness (HP:0003547)1.87774575
87Anomalous pulmonary venous return (HP:0010772)1.86315327
88Unsteady gait (HP:0002317)1.82106792
89Abnormality of the aortic arch (HP:0012303)1.81883344
90Vaginal atresia (HP:0000148)1.80521446
91Abnormality of cells of the erythroid lineage (HP:0012130)1.79849497
92Rib fusion (HP:0000902)1.79769994
93Retinal dysplasia (HP:0007973)1.78914985
94Abnormality of the renal collecting system (HP:0004742)1.77125762
95Impaired vibration sensation in the lower limbs (HP:0002166)1.77018469
96Dyskinesia (HP:0100660)1.75143595
97Abnormality of the intervertebral disk (HP:0005108)1.74640318
98Focal seizures (HP:0007359)1.72329853
99Delayed epiphyseal ossification (HP:0002663)1.71282487
100Lipid accumulation in hepatocytes (HP:0006561)1.69250450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK5.00917283
2BMPR1B3.73953751
3MAP3K43.16451921
4NME23.09622768
5PINK12.58493332
6MAP2K72.33497199
7ACVR1B2.30559386
8CDK192.19207182
9VRK22.03966429
10MAP3K91.95911413
11DYRK1A1.94318156
12MAPK151.92687836
13TYRO31.86842236
14MAP2K41.84934038
15PRKD31.78604762
16CASK1.58465595
17MARK21.54276061
18EPHA41.53302780
19SGK21.52967603
20MARK11.52279470
21MAP3K61.49549136
22EIF2AK31.46739975
23SGK2231.45746651
24SGK4941.45746651
25CSNK1G21.45073145
26BCKDK1.44354243
27PNCK1.44351402
28MAP3K101.36370229
29NTRK31.34162783
30AKT31.30797604
31MAPK131.30000286
32KIT1.29848429
33ICK1.28961606
34DYRK31.25760621
35CSNK1G11.19385683
36TAF11.07489693
37WNK31.04461108
38CSNK1G31.01423880
39BRD40.96923950
40MINK10.96201033
41BRAF0.92717409
42OXSR10.91441001
43NME10.90955902
44PRKCG0.89153211
45DYRK20.87285869
46TIE10.86884104
47PRKCQ0.83430754
48SGK30.83108329
49MAP3K110.79122447
50PRPF4B0.76885951
51STK110.74926960
52NTRK20.74818733
53CSF1R0.73341541
54STK240.71005289
55SIK10.70912048
56CAMK1G0.69483484
57ABL20.66867589
58CDK11A0.66533656
59CDK50.65045259
60RPS6KA20.65030911
61MAP3K50.64532173
62NLK0.63978965
63KDR0.63336578
64ARAF0.63006716
65FES0.62384638
66SGK10.61673912
67PRKCZ0.60840159
68VRK10.59768721
69TGFBR10.59170525
70CDK140.58844198
71TLK10.57693969
72MELK0.55984266
73RPS6KA60.55536436
74PRKCH0.55186722
75DYRK1B0.54122182
76MAP2K20.53514924
77CDK150.52852060
78STK30.51236983
79GRK50.51172518
80MAP3K20.50496556
81CAMK2B0.47775333
82RPS6KC10.46430169
83RPS6KL10.46430169
84CDK180.46206543
85MAPKAPK50.45551335
86PIM20.44416685
87CAMK2D0.43456520
88CAMK10.42982430
89PRKACA0.42849290
90CAMK2A0.41607799
91BCR0.39874933
92STK390.38610285
93STK38L0.38220911
94CAMK2G0.36736658
95WNK40.36414154
96RPS6KA30.34839307
97CAMKK20.33894096
98PRKACG0.33859959
99RET0.33765273
100PAK30.33712942

Predicted pathways (KEGG)

RankGene SetZ-score
1Parkinsons disease_Homo sapiens_hsa050124.35198405
2Oxidative phosphorylation_Homo sapiens_hsa001903.87783323
3Ribosome_Homo sapiens_hsa030103.67659783
4Huntingtons disease_Homo sapiens_hsa050163.09918434
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.97926485
6Fatty acid elongation_Homo sapiens_hsa000622.39961944
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.28395008
8Alzheimers disease_Homo sapiens_hsa050102.23906387
9Nicotine addiction_Homo sapiens_hsa050332.22032357
10Cardiac muscle contraction_Homo sapiens_hsa042602.13728249
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03540145
12Synaptic vesicle cycle_Homo sapiens_hsa047211.86915207
13Taste transduction_Homo sapiens_hsa047421.81634316
14Linoleic acid metabolism_Homo sapiens_hsa005911.80605801
15Dorso-ventral axis formation_Homo sapiens_hsa043201.76089714
16Steroid biosynthesis_Homo sapiens_hsa001001.72495147
17Cocaine addiction_Homo sapiens_hsa050301.71812005
18Serotonergic synapse_Homo sapiens_hsa047261.69085312
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67494780
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60425234
21Tyrosine metabolism_Homo sapiens_hsa003501.57771966
22Collecting duct acid secretion_Homo sapiens_hsa049661.50015343
23Phenylalanine metabolism_Homo sapiens_hsa003601.49199981
24Regulation of autophagy_Homo sapiens_hsa041401.48270350
25Pyruvate metabolism_Homo sapiens_hsa006201.38459935
26Phototransduction_Homo sapiens_hsa047441.37402579
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37033010
28Dopaminergic synapse_Homo sapiens_hsa047281.36842585
29Fat digestion and absorption_Homo sapiens_hsa049751.34099634
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28982520
31Axon guidance_Homo sapiens_hsa043601.28149867
32Long-term depression_Homo sapiens_hsa047301.25878137
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20090384
34Notch signaling pathway_Homo sapiens_hsa043301.17790165
35RNA polymerase_Homo sapiens_hsa030201.11973172
36Insulin secretion_Homo sapiens_hsa049111.11155615
37TGF-beta signaling pathway_Homo sapiens_hsa043501.07468667
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03938443
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97920854
40Amphetamine addiction_Homo sapiens_hsa050310.97621331
41Olfactory transduction_Homo sapiens_hsa047400.93821867
42Fatty acid biosynthesis_Homo sapiens_hsa000610.88770497
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88650462
44Cholinergic synapse_Homo sapiens_hsa047250.87941305
45Circadian rhythm_Homo sapiens_hsa047100.86442372
46Propanoate metabolism_Homo sapiens_hsa006400.84879667
47Morphine addiction_Homo sapiens_hsa050320.84492024
48Peroxisome_Homo sapiens_hsa041460.84206765
49ABC transporters_Homo sapiens_hsa020100.82389337
50GABAergic synapse_Homo sapiens_hsa047270.82118496
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81535178
52Alcoholism_Homo sapiens_hsa050340.81387595
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78084853
54cAMP signaling pathway_Homo sapiens_hsa040240.76336852
55Vitamin digestion and absorption_Homo sapiens_hsa049770.74436521
56Arachidonic acid metabolism_Homo sapiens_hsa005900.72350224
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72277398
58Glutamatergic synapse_Homo sapiens_hsa047240.68886096
59Wnt signaling pathway_Homo sapiens_hsa043100.66862470
60Ether lipid metabolism_Homo sapiens_hsa005650.62687637
61mRNA surveillance pathway_Homo sapiens_hsa030150.60722608
62Protein export_Homo sapiens_hsa030600.59770025
63Fanconi anemia pathway_Homo sapiens_hsa034600.59724575
64Circadian entrainment_Homo sapiens_hsa047130.58653494
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57198233
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55730440
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54836649
68Proteasome_Homo sapiens_hsa030500.54754126
69Chemical carcinogenesis_Homo sapiens_hsa052040.53438681
70AMPK signaling pathway_Homo sapiens_hsa041520.53071960
71beta-Alanine metabolism_Homo sapiens_hsa004100.52422204
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50829582
73Metabolic pathways_Homo sapiens_hsa011000.50710820
74Ras signaling pathway_Homo sapiens_hsa040140.50462655
75Basal cell carcinoma_Homo sapiens_hsa052170.50403951
76Butanoate metabolism_Homo sapiens_hsa006500.49050667
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49043517
78Long-term potentiation_Homo sapiens_hsa047200.48824737
79Bile secretion_Homo sapiens_hsa049760.48658409
80Retinol metabolism_Homo sapiens_hsa008300.45954252
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.45596103
82Tryptophan metabolism_Homo sapiens_hsa003800.44816496
83Folate biosynthesis_Homo sapiens_hsa007900.44767662
84Arginine and proline metabolism_Homo sapiens_hsa003300.42726470
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42669570
86Melanogenesis_Homo sapiens_hsa049160.40368576
87Sphingolipid metabolism_Homo sapiens_hsa006000.39763474
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38613410
89Basal transcription factors_Homo sapiens_hsa030220.37386131
90PPAR signaling pathway_Homo sapiens_hsa033200.34771076
91Hedgehog signaling pathway_Homo sapiens_hsa043400.33132772
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.33117784
93Glutathione metabolism_Homo sapiens_hsa004800.32444193
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31333671
95Asthma_Homo sapiens_hsa053100.31300214
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27089171
97RNA degradation_Homo sapiens_hsa030180.27047743
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25883511
99Colorectal cancer_Homo sapiens_hsa052100.25817755
100Homologous recombination_Homo sapiens_hsa034400.25395742

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