ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of T cell tolerance induction (GO:0002664)	7.56643200
2	positive regulation of mast cell degranulation (GO:0043306)	6.75440770
3	positive regulation of mast cell activation involved in immune response (GO:0033008)	6.75440770
4	regulation of tolerance induction (GO:0002643)	6.63805529
5	regulation of meiosis I (GO:0060631)	6.57698754
6	regulation of T cell cytokine production (GO:0002724)	5.85674334
7	interferon-gamma secretion (GO:0072643)	5.80253904
8	positive regulation of mast cell activation (GO:0033005)	5.75487052
9	cellular biogenic amine biosynthetic process (GO:0042401)	5.50554768
10	amine biosynthetic process (GO:0009309)	5.50032399
11	T cell apoptotic process (GO:0070231)	5.42661402
12	regulation of mast cell activation involved in immune response (GO:0033006)	5.37362101
13	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	5.19468163
14	peroxisome fission (GO:0016559)	4.98922482
15	regulation of mast cell degranulation (GO:0043304)	4.70596100
16	positive regulation of leukocyte degranulation (GO:0043302)	4.70405310
17	neutrophil activation involved in immune response (GO:0002283)	4.66483310
18	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	4.59608440
19	negative regulation of defense response to virus (GO:0050687)	4.54519346
20	angiotensin maturation (GO:0002003)	4.44432723
21	lymphocyte apoptotic process (GO:0070227)	4.43202305
22	catechol-containing compound biosynthetic process (GO:0009713)	4.31535993
23	catecholamine biosynthetic process (GO:0042423)	4.31535993
24	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.29538967
25	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.29157641
26	regulation of acyl-CoA biosynthetic process (GO:0050812)	4.26855316
27	male meiosis (GO:0007140)	4.17259966
28	regulation of autophagic vacuole assembly (GO:2000785)	4.16122526
29	mRNA cleavage (GO:0006379)	4.13720844
30	regulation of coenzyme metabolic process (GO:0051196)	4.08498997
31	regulation of cofactor metabolic process (GO:0051193)	4.08498997
32	resolution of meiotic recombination intermediates (GO:0000712)	4.07393328
33	cytokine secretion (GO:0050663)	4.03855134
34	N-terminal protein amino acid acetylation (GO:0006474)	4.02441587
35	regulation of mast cell activation (GO:0033003)	4.00871171
36	leukocyte apoptotic process (GO:0071887)	3.98349097
37	positive regulation of regulated secretory pathway (GO:1903307)	3.87955015
38	synaptonemal complex assembly (GO:0007130)	3.78914267
39	regulation of myeloid leukocyte mediated immunity (GO:0002886)	3.74308817
40	regulation of vacuole organization (GO:0044088)	3.67866181
41	intestinal epithelial cell development (GO:0060576)	3.61174882
42	replication fork processing (GO:0031297)	3.56526184
43	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	3.54382613
44	neutrophil activation (GO:0042119)	3.51211007
45	regulation of leukocyte degranulation (GO:0043300)	3.50758648
46	piRNA metabolic process (GO:0034587)	3.48774526
47	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.48100440
48	regulation of phospholipase A2 activity (GO:0032429)	3.40708699
49	synapsis (GO:0007129)	3.37374665
50	germ cell migration (GO:0008354)	3.36984679
51	chromosome organization involved in meiosis (GO:0070192)	3.34691409
52	synaptonemal complex organization (GO:0070193)	3.30253989
53	regulation of proton transport (GO:0010155)	3.24684204
54	regulation of sulfur metabolic process (GO:0042762)	3.23772645
55	regulation of oxidative stress-induced neuron death (GO:1903203)	3.22180090
56	cellular polysaccharide catabolic process (GO:0044247)	3.18879463
57	glycogen catabolic process (GO:0005980)	3.18373331
58	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.16106883
59	glucan catabolic process (GO:0009251)	3.15562890
60	definitive hemopoiesis (GO:0060216)	3.14415203
61	androgen biosynthetic process (GO:0006702)	3.13964938
62	genitalia morphogenesis (GO:0035112)	3.12466472
63	oocyte maturation (GO:0001556)	3.10935242
64	histone H3-K36 demethylation (GO:0070544)	3.10236816
65	positive regulation of meiosis (GO:0045836)	3.06935665
66	polysaccharide catabolic process (GO:0000272)	3.06910944
67	regulation of regulated secretory pathway (GO:1903305)	3.05101235
68	uterus development (GO:0060065)	3.03390937
69	galactose catabolic process (GO:0019388)	3.02627732
70	positive regulation of meiotic cell cycle (GO:0051446)	3.01896020
71	gonadal mesoderm development (GO:0007506)	3.00361014
72	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	2.99958499
73	granulocyte activation (GO:0036230)	2.98643495
74	glucocorticoid biosynthetic process (GO:0006704)	2.97759778
75	DNA methylation involved in gamete generation (GO:0043046)	2.96740312
76	meiotic nuclear division (GO:0007126)	2.96323627
77	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.92542536
78	regulation of interleukin-5 production (GO:0032674)	2.92228089
79	galactose metabolic process (GO:0006012)	2.91116418
80	embryonic process involved in female pregnancy (GO:0060136)	2.90963341
81	DNA replication-dependent nucleosome organization (GO:0034723)	2.90347441
82	DNA replication-dependent nucleosome assembly (GO:0006335)	2.90347441
83	face development (GO:0060324)	2.86565102
84	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.84903622
85	negative regulation of response to biotic stimulus (GO:0002832)	2.83428479
86	negative regulation of striated muscle cell apoptotic process (GO:0010664)	2.78736171
87	centriole assembly (GO:0098534)	2.77207745
88	DNA synthesis involved in DNA repair (GO:0000731)	2.75820195
89	lipoxygenase pathway (GO:0019372)	2.75640768
90	production of molecular mediator involved in inflammatory response (GO:0002532)	2.75304839
91	male meiosis I (GO:0007141)	2.74995618
92	negative regulation of translational initiation (GO:0045947)	2.74284663
93	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	2.65754485
94	regulation of activated T cell proliferation (GO:0046006)	2.62250583
95	glucan metabolic process (GO:0044042)	2.61721438
96	cellular glucan metabolic process (GO:0006073)	2.61721438
97	glycogen metabolic process (GO:0005977)	2.61666294
98	leukotriene biosynthetic process (GO:0019370)	2.58286395
99	mesonephros development (GO:0001823)	2.56800340
100	imidazole-containing compound metabolic process (GO:0052803)	10.9374270

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.54127916
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.60480207
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.82256803
4	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.64050025
5	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.10746441
6	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	3.05745062
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.92871892
8	AR_21909140_ChIP-Seq_LNCAP_Human	2.14670152
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	12.6301393
10	IGF1R_20145208_ChIP-Seq_DFB_Human	1.94736346
11	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.86962252
12	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.86057632
13	SPI1_23547873_ChIP-Seq_NB4_Human	1.78902873
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.74995205
15	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.61459986
16	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.61459986
17	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.61459986
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53666346
19	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.53215819
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49342008
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45916725
22	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.38114597
23	GATA1_22025678_ChIP-Seq_K562_Human	1.37001523
24	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.36653106
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.33198405
26	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.32179088
27	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29030089
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.27947396
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.27892923
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.27857955
31	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.27584275
32	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.26431168
33	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.25844778
34	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.23484161
35	TFEB_21752829_ChIP-Seq_HELA_Human	1.20837203
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.18870600
37	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.15340044
38	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.15054417
39	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.14184101
40	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.14135723
41	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13952675
42	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.12926628
43	MYB_26560356_Chip-Seq_TH2_Human	1.10523624
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10490210
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.09847373
46	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.09804075
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08680279
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.07548463
49	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.06803981
50	ELF5_23300383_ChIP-Seq_T47D_Human	1.05465542
51	CHD1_26751641_Chip-Seq_LNCaP_Human	1.03563829
52	ERA_21632823_ChIP-Seq_H3396_Human	0.98753210
53	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.98719758
54	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.97141241
55	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.95835840
56	SPI1_20517297_ChIP-Seq_HL60_Human	0.94479922
57	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.94180158
58	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.93604421
59	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93115836
60	GATA3_26560356_Chip-Seq_TH2_Human	0.92497684
61	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.92146311
62	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.91804211
63	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90384396
64	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.90229794
65	VDR_24763502_ChIP-Seq_THP-1_Human	0.90183575
66	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.90143045
67	UTX_26944678_Chip-Seq_JUKART_Human	0.90107830
68	SCL_19346495_ChIP-Seq_HPC-7_Human	0.89465450
69	SPI1_23127762_ChIP-Seq_K562_Human	0.88378542
70	NANOG_20526341_ChIP-Seq_ESCs_Human	0.84423329
71	EOMES_21245162_ChIP-Seq_HESCs_Human	0.83933865
72	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.83803151
73	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.83696275
74	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.82415432
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.82329043
76	VDR_22108803_ChIP-Seq_LS180_Human	0.79315625
77	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.78439144
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.78257216
79	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.77765956
80	HOXB7_26014856_ChIP-Seq_BT474_Human	0.74207820
81	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.74199412
82	GATA6_25053715_ChIP-Seq_YYC3_Human	0.73951555
83	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.73726708
84	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.73159839
85	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.73140509
86	OCT4_20526341_ChIP-Seq_ESCs_Human	0.72185469
87	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.71669462
88	MYB_26560356_Chip-Seq_TH1_Human	0.71410548
89	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.71013022
90	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.70473984
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.69811511
92	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.69386309
93	MAF_26560356_Chip-Seq_TH2_Human	0.69214924
94	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.68484422
95	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.68045465
96	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.66035664
97	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.65439253
98	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.65210371
99	CTCF_21964334_Chip-Seq_Bcells_Human	0.65091776
100	RAC3_21632823_ChIP-Seq_H3396_Human	0.64922426

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004264_abnormal_extraembryonic_tissu	4.18226121
2	MP0003693_abnormal_embryo_hatching	3.59993180
3	MP0003136_yellow_coat_color	3.35016326
4	MP0005075_abnormal_melanosome_morpholog	3.26859998
5	MP0002735_abnormal_chemical_nociception	3.22480055
6	MP0003806_abnormal_nucleotide_metabolis	3.21951384
7	MP0009697_abnormal_copulation	2.97257326
8	MP0005646_abnormal_pituitary_gland	2.82045050
9	MP0002132_abnormal_respiratory_system	2.77878398
10	MP0008004_abnormal_stomach_pH	2.73282855
11	MP0002160_abnormal_reproductive_system	2.48237838
12	MP0003315_abnormal_perineum_morphology	2.39029554
13	MP0005058_abnormal_lysosome_morphology	2.23475997
14	MP0008995_early_reproductive_senescence	2.21565463
15	MP0008058_abnormal_DNA_repair	2.18848277
16	MP0000465_gastrointestinal_hemorrhage	2.12873714
17	MP0004381_abnormal_hair_follicle	2.11064097
18	MP0003195_calcinosis	2.10828771
19	MP0000537_abnormal_urethra_morphology	1.95974844
20	MP0005174_abnormal_tail_pigmentation	1.92200617
21	MP0005503_abnormal_tendon_morphology	1.90423736
22	MP0002127_abnormal_cardiovascular_syste	1.88154471
23	MP0009840_abnormal_foam_cell	1.72161101
24	MP0002210_abnormal_sex_determination	1.70770821
25	MP0010094_abnormal_chromosome_stability	1.70067060
26	MP0005647_abnormal_sex_gland	1.69313332
27	MP0006082_CNS_inflammation	1.67382250
28	MP0001145_abnormal_male_reproductive	1.67123464
29	MP0009115_abnormal_fat_cell	1.66620501
30	MP0001929_abnormal_gametogenesis	1.60375439
31	MP0001873_stomach_inflammation	1.59570305
32	MP0008057_abnormal_DNA_replication	1.59379170
33	MP0004147_increased_porphyrin_level	1.52864339
34	MP0004782_abnormal_surfactant_physiolog	1.41123617
35	MP0000653_abnormal_sex_gland	1.40144938
36	MP0010386_abnormal_urinary_bladder	1.36169767
37	MP0004957_abnormal_blastocyst_morpholog	1.28196074
38	MP0010368_abnormal_lymphatic_system	1.26940200
39	MP0003698_abnormal_male_reproductive	1.26531710
40	MP0003183_abnormal_peptide_metabolism	1.24048507
41	MP0002108_abnormal_muscle_morphology	1.22207985
42	MP0005464_abnormal_platelet_physiology	1.18300926
43	MP0003638_abnormal_response/metabolism_	1.18046777
44	MP0005389_reproductive_system_phenotype	1.17381887
45	MP0001730_embryonic_growth_arrest	1.16370236
46	MP0003283_abnormal_digestive_organ	1.16167790
47	MP0008877_abnormal_DNA_methylation	1.15466201
48	MP0005377_hearing/vestibular/ear_phenot	1.10219318
49	MP0003878_abnormal_ear_physiology	1.10219318
50	MP0002148_abnormal_hypersensitivity_rea	1.09982547
51	MP0005367_renal/urinary_system_phenotyp	1.08532304
52	MP0000516_abnormal_urinary_system	1.08532304
53	MP0000703_abnormal_thymus_morphology	1.05236768
54	MP0002796_impaired_skin_barrier	1.03787690
55	MP0008260_abnormal_autophagy	1.03713687
56	MP0000490_abnormal_crypts_of	1.03185053
57	MP0002722_abnormal_immune_system	1.02898312
58	MP0003724_increased_susceptibility_to	1.00903353
59	MP0005076_abnormal_cell_differentiation	1.00507657
60	MP0003936_abnormal_reproductive_system	0.98655765
61	MP0005248_abnormal_Harderian_gland	0.98627758
62	MP0001849_ear_inflammation	0.98527573
63	MP0010234_abnormal_vibrissa_follicle	0.95194261
64	MP0005310_abnormal_salivary_gland	0.93835888
65	MP0005451_abnormal_body_composition	0.93477432
66	MP0002086_abnormal_extraembryonic_tissu	0.92774192
67	MP0005083_abnormal_biliary_tract	0.92129480
68	MP0003763_abnormal_thymus_physiology	0.91788532
69	MP0005334_abnormal_fat_pad	0.91655745
70	MP0002971_abnormal_brown_adipose	0.89019813
71	MP0001661_extended_life_span	0.88950734
72	MP0002405_respiratory_system_inflammati	0.87691423
73	MP0002398_abnormal_bone_marrow	0.81629687
74	MP0003077_abnormal_cell_cycle	0.80906754
75	MP0005187_abnormal_penis_morphology	0.80070258
76	MP0002419_abnormal_innate_immunity	0.77999625
77	MP0008961_abnormal_basal_metabolism	0.77494861
78	MP0004484_altered_response_of	0.75699579
79	MP0001119_abnormal_female_reproductive	0.75325025
80	MP0002429_abnormal_blood_cell	0.75228672
81	MP0000716_abnormal_immune_system	0.74986216
82	MP0003111_abnormal_nucleus_morphology	0.74858709
83	MP0002970_abnormal_white_adipose	0.74535426
84	MP0003938_abnormal_ear_development	0.73542749
85	MP0006036_abnormal_mitochondrial_physio	0.71586244
86	MP0001672_abnormal_embryogenesis/_devel	0.70895798
87	MP0005380_embryogenesis_phenotype	0.70895798
88	MP0001919_abnormal_reproductive_system	0.69820543
89	MP0001819_abnormal_immune_cell	0.69255344
90	MP0002420_abnormal_adaptive_immunity	0.68009393
91	MP0005220_abnormal_exocrine_pancreas	0.67919657
92	MP0004233_abnormal_muscle_weight	0.67369425
93	MP0006035_abnormal_mitochondrial_morpho	0.66283378
94	MP0010678_abnormal_skin_adnexa	0.66233976
95	MP0003699_abnormal_female_reproductive	0.65702543
96	MP0001697_abnormal_embryo_size	0.64171465
97	MP0002088_abnormal_embryonic_growth/wei	0.61495114
98	MP0003984_embryonic_growth_retardation	0.60901782
99	MP0002161_abnormal_fertility/fecundity	0.60090170
100	MP0002277_abnormal_respiratory_mucosa	0.57474740

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the columella (HP:0009929)	4.97601111
2	Gonadotropin excess (HP:0000837)	4.90257335
3	Reduced antithrombin III activity (HP:0001976)	4.54741258
4	Male infertility (HP:0003251)	4.40984456
5	Right ventricular cardiomyopathy (HP:0011663)	4.00317894
6	Gonadal dysgenesis (HP:0000133)	3.76636393
7	High anterior hairline (HP:0009890)	3.68148469
8	Vacuolated lymphocytes (HP:0001922)	3.54225190
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.48499458
10	Abnormality of macrophages (HP:0004311)	3.37372206
11	Abnormality of pyrimidine metabolism (HP:0004353)	3.23364160
12	Hypophosphatemic rickets (HP:0004912)	3.17461264
13	Acute hepatic failure (HP:0006554)	3.03537901
14	Testicular neoplasm (HP:0010788)	2.98447314
15	Proximal tubulopathy (HP:0000114)	2.92584729
16	Failure to thrive in infancy (HP:0001531)	2.83069924
17	Premature ovarian failure (HP:0008209)	2.75582208
18	Abnormal protein N-linked glycosylation (HP:0012347)	2.75233953
19	Abnormal protein glycosylation (HP:0012346)	2.75233953
20	Abnormal glycosylation (HP:0012345)	2.75233953
21	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.75233953
22	Abnormality of the frontal sinuses (HP:0002687)	2.75213602
23	Osteomalacia (HP:0002749)	2.74418542
24	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.71210469
25	Type I transferrin isoform profile (HP:0003642)	2.68235342
26	Cutaneous melanoma (HP:0012056)	2.66056938
27	Congenital ichthyosiform erythroderma (HP:0007431)	2.64447997
28	Self-mutilation (HP:0000742)	2.54075304
29	Capillary hemangiomas (HP:0005306)	2.51617616
30	Episodic fever (HP:0001954)	2.44287961
31	Autoimmune thrombocytopenia (HP:0001973)	2.42823033
32	Pili torti (HP:0003777)	2.42251831
33	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.40449589
34	Resting tremor (HP:0002322)	2.40350574
35	Broad nasal tip (HP:0000455)	2.38727209
36	Eczematoid dermatitis (HP:0000976)	2.38656458
37	Proximal placement of thumb (HP:0009623)	2.37248717
38	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.36666837
39	Ventricular fibrillation (HP:0001663)	2.27086825
40	Deviation of the thumb (HP:0009603)	2.25600975
41	Secondary amenorrhea (HP:0000869)	2.23972281
42	Germ cell neoplasia (HP:0100728)	2.23857589
43	Volvulus (HP:0002580)	2.22821060
44	Subcapsular cataract (HP:0000523)	2.22303017
45	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.20922893
46	Absent thumb (HP:0009777)	2.20398399
47	Bone marrow hypocellularity (HP:0005528)	2.19938465
48	Abnormality of T cell physiology (HP:0011840)	2.19197240
49	Intrahepatic cholestasis (HP:0001406)	2.18740085
50	Thoracic kyphosis (HP:0002942)	2.18191227
51	Abnormality of the costochondral junction (HP:0000919)	2.09688592
52	Premature graying of hair (HP:0002216)	2.09272358
53	Generalized aminoaciduria (HP:0002909)	2.08611940
54	Nausea (HP:0002018)	2.08075751
55	Palpitations (HP:0001962)	2.07404353
56	Chromsome breakage (HP:0040012)	2.04647950
57	Rickets (HP:0002748)	2.02367971
58	Neurodegeneration (HP:0002180)	2.00224969
59	Inflammation of the large intestine (HP:0002037)	1.98922860
60	Colitis (HP:0002583)	1.96109996
61	Duplicated collecting system (HP:0000081)	1.95968242
62	Abnormality of the renal collecting system (HP:0004742)	1.95872799
63	Asymmetry of the thorax (HP:0001555)	1.95080362
64	Petechiae (HP:0000967)	1.93622457
65	Renal Fanconi syndrome (HP:0001994)	1.92007499
66	Recurrent corneal erosions (HP:0000495)	1.91895198
67	Chronic mucocutaneous candidiasis (HP:0002728)	1.90335444
68	Recurrent cutaneous fungal infections (HP:0011370)	1.90335444
69	Microglossia (HP:0000171)	1.90181952
70	Ureteral duplication (HP:0000073)	1.90110173
71	Septate vagina (HP:0001153)	1.89132941
72	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.85536885
73	Autoimmune hemolytic anemia (HP:0001890)	1.85352248
74	Recurrent abscess formation (HP:0002722)	1.85270857
75	Spastic diplegia (HP:0001264)	1.83894358
76	Male pseudohermaphroditism (HP:0000037)	1.83198661
77	Microretrognathia (HP:0000308)	1.81770785
78	Gastrointestinal inflammation (HP:0004386)	1.79359802
79	Rough bone trabeculation (HP:0100670)	1.77066081
80	Abnormality of the basal ganglia (HP:0002134)	1.75245737
81	Abnormal trabecular bone morphology (HP:0100671)	1.71651115
82	Progressive neurologic deterioration (HP:0002344)	1.71038002
83	Recurrent sinusitis (HP:0011108)	1.70122437
84	Abnormal hair laboratory examination (HP:0003328)	1.68714342
85	Lip pit (HP:0100267)	1.68632625
86	Cellular immunodeficiency (HP:0005374)	1.67424472
87	Decreased lacrimation (HP:0000633)	1.66507410
88	Facial hemangioma (HP:0000329)	1.65942822
89	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.64978285
90	Abnormality of the preputium (HP:0100587)	1.64833496
91	Hypothermia (HP:0002045)	1.63743548
92	Cupped ear (HP:0000378)	1.62236491
93	Abnormality of urine glucose concentration (HP:0011016)	1.61318234
94	Glycosuria (HP:0003076)	1.61318234
95	Recurrent viral infections (HP:0004429)	1.61270671
96	Abnormality of lateral ventricle (HP:0030047)	1.61034278
97	Aplastic anemia (HP:0001915)	1.60356228
98	Abnormality of the intrinsic pathway (HP:0010989)	1.59930309
99	Amyotrophic lateral sclerosis (HP:0007354)	1.59774855
100	Abnormality of the lumbar spine (HP:0100712)	1.59400970

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	7.63773663
2	MARK3	3.34568056
3	PDK2	3.31507536
4	MYLK	3.28818118
5	PIK3CA	2.74477272
6	STK38L	2.47121375
7	PLK4	2.28752823
8	LATS1	2.28643500
9	PINK1	2.21625772
10	GRK6	2.14700417
11	PKN2	2.13637754
12	NME2	2.12957549
13	STK39	1.98513008
14	ACVR1B	1.87569960
15	STK38	1.78601167
16	STK16	1.78588337
17	TNIK	1.77830896
18	TAOK1	1.74774744
19	CDK3	1.68675325
20	SIK3	1.62649889
21	PNCK	1.51875559
22	EIF2AK3	1.43632980
23	ZAK	1.38095010
24	NEK2	1.36950467
25	CDK19	1.30712488
26	MAP3K12	1.28810871
27	FRK	1.27157496
28	BCKDK	1.23586191
29	FER	1.21095965
30	MATK	1.13463635
31	TRIB3	1.12615360
32	TNK2	1.11359351
33	FGR	1.04785949
34	OXSR1	1.01104441
35	PBK	1.00414883
36	BLK	0.94748114
37	BTK	0.92689495
38	AKT2	0.91428699
39	CSNK1A1L	0.90808438
40	FES	0.89618146
41	PIM1	0.88248789
42	ILK	0.87004043
43	MAP3K2	0.84666668
44	DYRK3	0.79879832
45	MELK	0.79193149
46	RPS6KB1	0.77827673
47	PRKG2	0.74653942
48	PRPF4B	0.74585268
49	PAK1	0.74155829
50	PLK1	0.73957859
51	TGFBR2	0.72310026
52	RPS6KB2	0.71102049
53	MOS	0.67623253
54	GRK1	0.67042520
55	CAMK1G	0.67041274
56	MAP3K1	0.62514880
57	PIK3CG	0.56847222
58	FGFR2	0.56785087
59	CLK1	0.56548322
60	IRAK2	0.54938133
61	EGFR	0.54780164
62	CDK7	0.54535528
63	AKT3	0.51524186
64	PAK4	0.50614995
65	IRAK4	0.49966107
66	PDK1	0.49334124
67	RPS6KA4	0.48805986
68	LYN	0.48135542
69	TAOK2	0.47468022
70	DAPK3	0.47303239
71	PRKCQ	0.46457946
72	TYK2	0.44813229
73	PRKD2	0.42920027
74	RET	0.42723190
75	MAP4K1	0.42411862
76	JAK2	0.42345767
77	AURKB	0.41800070
78	CSNK1G3	0.41707057
79	BMPR1B	0.40912527
80	MST4	0.40793630
81	PDPK1	0.38109833
82	YES1	0.36995600
83	ATR	0.36923204
84	TESK1	0.36298226
85	MAP3K5	0.35459484
86	CSK	0.35229092
87	CDK6	0.34533865
88	IKBKE	0.34176615
89	MAP3K10	0.32937565
90	OBSCN	0.32124576
91	STK10	0.31856733
92	LATS2	0.31635434
93	CSNK1G2	0.29905707
94	KSR1	0.29294192
95	SRPK1	0.27581393
96	MAPKAPK2	0.27475435
97	TGFBR1	0.26372374
98	LRRK2	0.25487429
99	CSNK1G1	0.24918098
100	MARK2	0.24006818

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Histidine metabolism_Homo sapiens_hsa00340	4.22440314
2	Other glycan degradation_Homo sapiens_hsa00511	3.97706625
3	Renin-angiotensin system_Homo sapiens_hsa04614	3.16673128
4	DNA replication_Homo sapiens_hsa03030	2.85269572
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.79104510
6	Asthma_Homo sapiens_hsa05310	2.57477967
7	Mismatch repair_Homo sapiens_hsa03430	2.52244453
8	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.19947683
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.07901427
10	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.98410119
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98052375
12	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.93227181
13	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.88181210
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86780964
15	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.83508681
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.75596265
17	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.70278348
18	Pancreatic secretion_Homo sapiens_hsa04972	1.58104580
19	Basal transcription factors_Homo sapiens_hsa03022	1.52704640
20	Regulation of autophagy_Homo sapiens_hsa04140	1.48470584
21	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.47370933
22	Olfactory transduction_Homo sapiens_hsa04740	1.42659026
23	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.39446976
24	Oocyte meiosis_Homo sapiens_hsa04114	1.39385763
25	Folate biosynthesis_Homo sapiens_hsa00790	1.38867759
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.37689939
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.30312977
28	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.28843079
29	Sulfur relay system_Homo sapiens_hsa04122	1.24398959
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.22344494
31	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.21475675
32	Steroid biosynthesis_Homo sapiens_hsa00100	1.20279577
33	mRNA surveillance pathway_Homo sapiens_hsa03015	1.19791840
34	Homologous recombination_Homo sapiens_hsa03440	1.19095896
35	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.17177728
36	Proteasome_Homo sapiens_hsa03050	1.16860371
37	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.14262691
38	Galactose metabolism_Homo sapiens_hsa00052	1.13214930
39	Cell cycle_Homo sapiens_hsa04110	1.12720883
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04395944
41	Endometrial cancer_Homo sapiens_hsa05213	1.01759820
42	RNA degradation_Homo sapiens_hsa03018	0.99398923
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.98887791
44	Butanoate metabolism_Homo sapiens_hsa00650	0.93470974
45	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.92833726
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92766844
47	Legionellosis_Homo sapiens_hsa05134	0.92572009
48	Prostate cancer_Homo sapiens_hsa05215	0.90826662
49	RNA transport_Homo sapiens_hsa03013	0.88104381
50	Platelet activation_Homo sapiens_hsa04611	0.83705912
51	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.83163058
52	Propanoate metabolism_Homo sapiens_hsa00640	0.79068822
53	Phenylalanine metabolism_Homo sapiens_hsa00360	0.78477512
54	Hepatitis B_Homo sapiens_hsa05161	0.78172588
55	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.75720830
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74335130
57	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.71486663
58	Glutathione metabolism_Homo sapiens_hsa00480	0.71455564
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70646289
60	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70454129
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.70206411
62	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.69693713
63	Acute myeloid leukemia_Homo sapiens_hsa05221	0.69091791
64	Hepatitis C_Homo sapiens_hsa05160	0.66287151
65	Lysosome_Homo sapiens_hsa04142	0.66269997
66	Protein digestion and absorption_Homo sapiens_hsa04974	0.65855045
67	Apoptosis_Homo sapiens_hsa04210	0.64619380
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.64096709
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64078346
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.61379056
71	Non-small cell lung cancer_Homo sapiens_hsa05223	0.61280909
72	Purine metabolism_Homo sapiens_hsa00230	0.60442076
73	AMPK signaling pathway_Homo sapiens_hsa04152	0.59357909
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58047709
75	Thyroid cancer_Homo sapiens_hsa05216	0.57527097
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.56444025
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55473200
78	Base excision repair_Homo sapiens_hsa03410	0.55174850
79	Arginine biosynthesis_Homo sapiens_hsa00220	0.50748661
80	p53 signaling pathway_Homo sapiens_hsa04115	0.48745784
81	Herpes simplex infection_Homo sapiens_hsa05168	0.48518573
82	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.48285732
83	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48037654
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47857266
85	Spliceosome_Homo sapiens_hsa03040	0.46012758
86	Peroxisome_Homo sapiens_hsa04146	0.45106099
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42619543
88	Non-homologous end-joining_Homo sapiens_hsa03450	0.39556049
89	Metabolic pathways_Homo sapiens_hsa01100	0.36862322
90	Choline metabolism in cancer_Homo sapiens_hsa05231	0.35454648
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34181560
92	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.34147747
93	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.33795589
94	Melanoma_Homo sapiens_hsa05218	0.32062162
95	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.27896893
96	Renal cell carcinoma_Homo sapiens_hsa05211	0.23725750
97	Osteoclast differentiation_Homo sapiens_hsa04380	0.22873864
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.22140456
99	Measles_Homo sapiens_hsa05162	0.21892445
100	Nitrogen metabolism_Homo sapiens_hsa00910	0.19880303

RHOXF1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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