ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement (GO:0003351)	9.45867078
2	cilium movement (GO:0003341)	8.43442536
3	axonemal dynein complex assembly (GO:0070286)	8.06463357
4	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	7.67490047
5	intestinal epithelial cell development (GO:0060576)	7.45355967
6	uterus development (GO:0060065)	7.38548335
7	vagina development (GO:0060068)	6.67732162
8	ear development (GO:0043583)	6.63798544
9	motile cilium assembly (GO:0044458)	6.23922856
10	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	5.91654085
11	regulation of meiosis I (GO:0060631)	5.41713018
12	proline biosynthetic process (GO:0006561)	5.18868013
13	female genitalia development (GO:0030540)	5.13025874
14	piRNA metabolic process (GO:0034587)	4.98711068
15	epithelial cell maturation (GO:0002070)	4.93080904
16	cilium or flagellum-dependent cell motility (GO:0001539)	4.90422484
17	synapsis (GO:0007129)	4.88953354
18	intracellular estrogen receptor signaling pathway (GO:0030520)	4.54197398
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.46129388
20	regulation of cell proliferation involved in kidney development (GO:1901722)	4.45775248
21	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)	4.31640941
22	ventricular system development (GO:0021591)	4.29114862
23	DNA synthesis involved in DNA repair (GO:0000731)	4.27668132
24	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	4.03861086
25	regulation of autophagic vacuole assembly (GO:2000785)	4.03661632
26	negative regulation of cell fate commitment (GO:0010454)	3.99558359
27	regulation of establishment of cell polarity (GO:2000114)	3.98730073
28	nucleoside diphosphate phosphorylation (GO:0006165)	3.96582985
29	regulation of vacuole organization (GO:0044088)	3.91459849
30	intraciliary transport (GO:0042073)	3.76550493
31	chromosome organization involved in meiosis (GO:0070192)	3.72843970
32	DNA methylation involved in gamete generation (GO:0043046)	3.70492547
33	eyelid development in camera-type eye (GO:0061029)	3.69765277
34	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.69182821
35	positive regulation of nitric-oxide synthase activity (GO:0051000)	3.68132920
36	prostate gland growth (GO:0060736)	3.67033704
37	axoneme assembly (GO:0035082)	3.60876233
38	male meiosis I (GO:0007141)	3.53791113
39	GTP biosynthetic process (GO:0006183)	3.53182406
40	lung secretory cell differentiation (GO:0061140)	3.50251785
41	synaptonemal complex assembly (GO:0007130)	3.46119079
42	lymphoid progenitor cell differentiation (GO:0002320)	3.44935797
43	proline metabolic process (GO:0006560)	3.43446596
44	ribosomal small subunit assembly (GO:0000028)	3.43358263
45	left/right axis specification (GO:0070986)	3.39942033
46	positive regulation of translational initiation (GO:0045948)	3.37353457
47	ADP metabolic process (GO:0046031)	3.37201387
48	folic acid transport (GO:0015884)	3.36436248
49	ribosomal small subunit biogenesis (GO:0042274)	3.35956683
50	regulation of histone H3-K27 methylation (GO:0061085)	3.31834126
51	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	3.28062003
52	mesonephros development (GO:0001823)	3.27467038
53	UTP biosynthetic process (GO:0006228)	3.26219067
54	mitotic sister chromatid cohesion (GO:0007064)	3.22467036
55	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.21317305
56	resolution of meiotic recombination intermediates (GO:0000712)	3.21027068
57	endocrine hormone secretion (GO:0060986)	3.20391538
58	branching involved in prostate gland morphogenesis (GO:0060442)	3.19447595
59	regulation of centriole replication (GO:0046599)	3.18344659
60	centriole replication (GO:0007099)	3.14667677
61	positive regulation of meiosis (GO:0045836)	3.14210302
62	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)	3.14126363
63	left/right pattern formation (GO:0060972)	3.13361652
64	positive regulation of cell fate commitment (GO:0010455)	3.09781080
65	norepinephrine metabolic process (GO:0042415)	3.07982982
66	outflow tract septum morphogenesis (GO:0003148)	3.06459745
67	negative regulation of interleukin-2 production (GO:0032703)	3.06217819
68	cardiac right ventricle morphogenesis (GO:0003215)	3.05357619
69	embryonic skeletal joint morphogenesis (GO:0060272)	3.04801019
70	interferon-gamma secretion (GO:0072643)	3.04132263
71	amyloid precursor protein catabolic process (GO:0042987)	3.03634478
72	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.02572032
73	positive regulation of meiotic cell cycle (GO:0051446)	3.01121330
74	adenine nucleotide transport (GO:0051503)	3.00326225
75	maternal placenta development (GO:0001893)	2.99873806
76	male meiosis (GO:0007140)	2.98736502
77	meiosis I (GO:0007127)	2.97271421
78	negative regulation of cell size (GO:0045792)	2.93430064
79	branching involved in mammary gland duct morphogenesis (GO:0060444)	2.93119847
80	negative regulation of meiosis (GO:0045835)	2.92939152
81	gonadal mesoderm development (GO:0007506)	2.92859781
82	centriole assembly (GO:0098534)	2.92181248
83	cellular response to interferon-alpha (GO:0035457)	2.91676164
84	synaptonemal complex organization (GO:0070193)	2.90726922
85	negative regulation of organelle assembly (GO:1902116)	2.88837500
86	trophectodermal cell differentiation (GO:0001829)	2.86632245
87	embryonic camera-type eye morphogenesis (GO:0048596)	2.85332078
88	CTP biosynthetic process (GO:0006241)	2.82050155
89	CTP metabolic process (GO:0046036)	2.82050155
90	TOR signaling (GO:0031929)	2.81758280
91	spermatid development (GO:0007286)	2.81380502
92	columnar/cuboidal epithelial cell development (GO:0002066)	2.76792206
93	cellular response to estradiol stimulus (GO:0071392)	2.75895041
94	maturation of SSU-rRNA (GO:0030490)	2.74330530
95	UTP metabolic process (GO:0046051)	2.73643127
96	negative regulation of oxidative stress-induced cell death (GO:1903202)	2.73236868
97	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.73189508
98	embryonic eye morphogenesis (GO:0048048)	2.73069623
99	negative regulation of DNA repair (GO:0045738)	2.71158165
100	mammary gland epithelial cell proliferation (GO:0033598)	2.69768736

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_20079471_ChIP-ChIP_T-47D_Human	5.66037184
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.93323231
3	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	3.19454585
4	E2F7_22180533_ChIP-Seq_HELA_Human	2.97531612
5	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.96549224
6	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.96549224
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.96549224
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.93035717
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.73707129
10	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.64989616
11	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.62130870
12	RUNX1_27514584_Chip-Seq_MCF-7_Human	2.40384480
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.35354295
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.34235786
15	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.24363090
16	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.21940069
17	KDM5A_27292631_Chip-Seq_BREAST_Human	2.19767701
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.16414306
19	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.08803180
20	ZFX_18555785_ChIP-Seq_MESCs_Mouse	2.07600440
21	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.99396189
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.94004300
23	DCP1A_22483619_ChIP-Seq_HELA_Human	1.84842099
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.84187097
25	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.82867720
26	RACK7_27058665_Chip-Seq_MCF-7_Human	1.80485559
27	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.79669427
28	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.78482766
29	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.77751062
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.76796928
31	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.73845648
32	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.72689518
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.71776431
34	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.71483671
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.69656201
36	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.66926489
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65857553
38	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.64529607
39	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.61338340
40	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.58505641
41	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.56810650
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.55921598
43	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.55116758
44	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.50864436
45	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.50399819
46	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.50346922
47	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.49281768
48	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.48853485
49	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.47219534
50	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.44897242
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.42209832
52	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	1.42088675
53	AHR_22903824_ChIP-Seq_MCF-7_Human	1.38996594
54	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.37075760
55	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.36881006
56	CHD1_26751641_Chip-Seq_LNCaP_Human	1.33300745
57	AR_21909140_ChIP-Seq_LNCAP_Human	1.29971889
58	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.29507815
59	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.28615255
60	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.27259990
61	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.20540643
62	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.19490619
63	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.13866429
64	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12511120
65	TFEB_21752829_ChIP-Seq_HELA_Human	1.12202594
66	ELF5_23300383_ChIP-Seq_T47D_Human	1.10648623
67	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.10551268
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09756749
69	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.09402128
70	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.07970732
71	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.07568205
72	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.06694728
73	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04311427
74	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.03469939
75	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.02668865
76	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.01271055
77	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.99930827
78	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.99349628
79	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.98967407
80	CREB1_26743006_Chip-Seq_LNCaP_Human	0.96561977
81	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.95716166
82	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.95255487
83	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94947437
84	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.94404194
85	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.93203665
86	CLOCK_20551151_ChIP-Seq_293T_Human	0.91938616
87	VDR_23849224_ChIP-Seq_CD4+_Human	0.89966947
88	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.89362785
89	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.88898985
90	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.88701113
91	FOXP3_21729870_ChIP-Seq_TREG_Human	0.87476485
92	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.86766269
93	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.86060699
94	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.85973045
95	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.82837852
96	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.82412400
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.82245689
98	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.82089978
99	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.81861923
100	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.81294313

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009780_abnormal_chondrocyte_physiolo	3.90140917
2	MP0008995_early_reproductive_senescence	3.56127000
3	MP0002160_abnormal_reproductive_system	3.47114294
4	MP0003806_abnormal_nucleotide_metabolis	3.34091127
5	MP0002736_abnormal_nociception_after	3.17872228
6	MP0004782_abnormal_surfactant_physiolog	3.10564623
7	MP0000566_synostosis	2.98633245
8	MP0001873_stomach_inflammation	2.98460022
9	MP0005646_abnormal_pituitary_gland	2.91686720
10	MP0004381_abnormal_hair_follicle	2.78325527
11	MP0002796_impaired_skin_barrier	2.77329574
12	MP0001727_abnormal_embryo_implantation	2.53943745
13	MP0000383_abnormal_hair_follicle	2.31733145
14	MP0002098_abnormal_vibrissa_morphology	2.27344837
15	MP0003123_paternal_imprinting	2.24318486
16	MP0004264_abnormal_extraembryonic_tissu	2.23850904
17	MP0005075_abnormal_melanosome_morpholog	2.19371679
18	MP0009672_abnormal_birth_weight	2.01539628
19	MP0010678_abnormal_skin_adnexa	2.01052222
20	MP0010030_abnormal_orbit_morphology	1.92360571
21	MP0003693_abnormal_embryo_hatching	1.90537194
22	MP0002277_abnormal_respiratory_mucosa	1.86224195
23	MP0000537_abnormal_urethra_morphology	1.83684605
24	MP0002734_abnormal_mechanical_nocicepti	1.81382955
25	MP0004957_abnormal_blastocyst_morpholog	1.77596138
26	MP0010386_abnormal_urinary_bladder	1.71360554
27	MP0000490_abnormal_crypts_of	1.68780156
28	MP0002210_abnormal_sex_determination	1.59770844
29	MP0000427_abnormal_hair_cycle	1.59045821
30	MP0005501_abnormal_skin_physiology	1.58568091
31	MP0001968_abnormal_touch/_nociception	1.57818426
32	MP0000627_abnormal_mammary_gland	1.54772559
33	MP0000470_abnormal_stomach_morphology	1.53001526
34	MP0005389_reproductive_system_phenotype	1.50931188
35	MP0000579_abnormal_nail_morphology	1.45012386
36	MP0010307_abnormal_tumor_latency	1.44389785
37	MP0003936_abnormal_reproductive_system	1.42426244
38	MP0001919_abnormal_reproductive_system	1.40889626
39	MP0003942_abnormal_urinary_system	1.39263327
40	MP0001929_abnormal_gametogenesis	1.38098037
41	MP0008877_abnormal_DNA_methylation	1.37882288
42	MP0001145_abnormal_male_reproductive	1.35513033
43	MP0000538_abnormal_urinary_bladder	1.28531118
44	MP0009703_decreased_birth_body	1.27925731
45	MP0001881_abnormal_mammary_gland	1.22372543
46	MP0004133_heterotaxia	1.21735172
47	MP0002822_catalepsy	1.18988968
48	MP0000462_abnormal_digestive_system	1.15069931
49	MP0000653_abnormal_sex_gland	1.14503699
50	MP0002184_abnormal_innervation	1.13027550
51	MP0008057_abnormal_DNA_replication	1.12872211
52	MP0004233_abnormal_muscle_weight	1.10699679
53	MP0002938_white_spotting	1.08239474
54	MP0003941_abnormal_skin_development	1.07418086
55	MP0005076_abnormal_cell_differentiation	1.07006317
56	MP0003698_abnormal_male_reproductive	1.03459283
57	MP0002085_abnormal_embryonic_tissue	1.02685656
58	MP0002751_abnormal_autonomic_nervous	1.01737994
59	MP0002653_abnormal_ependyma_morphology	0.98323041
60	MP0005220_abnormal_exocrine_pancreas	0.97224301
61	MP0005408_hypopigmentation	0.95864075
62	MP0002084_abnormal_developmental_patter	0.94136270
63	MP0001849_ear_inflammation	0.93963661
64	MP0001188_hyperpigmentation	0.92559636
65	MP0001672_abnormal_embryogenesis/_devel	0.89695298
66	MP0005380_embryogenesis_phenotype	0.89695298
67	MP0003938_abnormal_ear_development	0.88673522
68	MP0005187_abnormal_penis_morphology	0.88278499
69	MP0003937_abnormal_limbs/digits/tail_de	0.88041548
70	MP0002877_abnormal_melanocyte_morpholog	0.87534535
71	MP0001529_abnormal_vocalization	0.87274101
72	MP0001661_extended_life_span	0.86449373
73	MP0002088_abnormal_embryonic_growth/wei	0.85562776
74	MP0002896_abnormal_bone_mineralization	0.85336454
75	MP0001346_abnormal_lacrimal_gland	0.82057142
76	MP0008058_abnormal_DNA_repair	0.81465132
77	MP0001542_abnormal_bone_strength	0.79101890
78	MP0005377_hearing/vestibular/ear_phenot	0.78933735
79	MP0003878_abnormal_ear_physiology	0.78933735
80	MP0005409_darkened_coat_color	0.78761835
81	MP0000534_abnormal_ureter_morphology	0.76247573
82	MP0002163_abnormal_gland_morphology	0.75859904
83	MP0003959_abnormal_lean_body	0.75410276
84	MP0010234_abnormal_vibrissa_follicle	0.75221081
85	MP0002249_abnormal_larynx_morphology	0.75138474
86	MP0003705_abnormal_hypodermis_morpholog	0.74019337
87	MP0003984_embryonic_growth_retardation	0.73972214
88	MP0003786_premature_aging	0.73725566
89	MP0001697_abnormal_embryo_size	0.73036563
90	MP0003136_yellow_coat_color	0.72721815
91	MP0000767_abnormal_smooth_muscle	0.71038239
92	MP0005647_abnormal_sex_gland	0.70310278
93	MP0001340_abnormal_eyelid_morphology	0.69326136
94	MP0008932_abnormal_embryonic_tissue	0.69319918
95	MP0000467_abnormal_esophagus_morphology	0.69284777
96	MP0000647_abnormal_sebaceous_gland	0.69015288
97	MP0003943_abnormal_hepatobiliary_system	0.68190566
98	MP0004185_abnormal_adipocyte_glucose	0.66419528
99	MP0002080_prenatal_lethality	0.63804524
100	MP0001293_anophthalmia	0.62413412

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	7.12219120
2	Abnormal ciliary motility (HP:0012262)	7.01314751
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.95772399
4	Abnormal respiratory epithelium morphology (HP:0012253)	5.57211396
5	Abnormal respiratory motile cilium morphology (HP:0005938)	5.57211396
6	Septate vagina (HP:0001153)	5.25927512
7	Rhinitis (HP:0012384)	4.98852417
8	Asymmetry of the thorax (HP:0001555)	4.88219100
9	Absent/shortened dynein arms (HP:0200106)	4.60660706
10	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.60660706
11	Microglossia (HP:0000171)	3.89605784
12	Concave nail (HP:0001598)	3.89483387
13	J-shaped sella turcica (HP:0002680)	3.55684986
14	Absent frontal sinuses (HP:0002688)	3.52168312
15	Broad distal phalanx of finger (HP:0009836)	3.50685020
16	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.30510503
17	Chronic bronchitis (HP:0004469)	3.21867709
18	Bronchiectasis (HP:0002110)	3.17835184
19	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.13198109
20	Thin bony cortex (HP:0002753)	3.12305211
21	Germ cell neoplasia (HP:0100728)	3.10159774
22	Occipital encephalocele (HP:0002085)	2.96508169
23	Abnormality of midbrain morphology (HP:0002418)	2.92678629
24	Molar tooth sign on MRI (HP:0002419)	2.92678629
25	Abnormality of the phalanges of the hallux (HP:0010057)	2.91276774
26	Nasal polyposis (HP:0100582)	2.90585187
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.83990399
28	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.75423259
29	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.75423259
30	Papillary thyroid carcinoma (HP:0002895)	2.67336635
31	Short nail (HP:0001799)	2.66120542
32	Lip pit (HP:0100267)	2.61863571
33	Abnormality of the frontal sinuses (HP:0002687)	2.60417664
34	Renal dysplasia (HP:0000110)	2.51995449
35	Hypoparathyroidism (HP:0000829)	2.49180738
36	Nephronophthisis (HP:0000090)	2.46342181
37	Breast carcinoma (HP:0003002)	2.46251603
38	Abnormality of the dental root (HP:0006486)	2.46081823
39	Taurodontia (HP:0000679)	2.46081823
40	Abnormality of permanent molar morphology (HP:0011071)	2.46081823
41	Sparse lateral eyebrow (HP:0005338)	2.44803459
42	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.44028703
43	Testicular neoplasm (HP:0010788)	2.41305779
44	Chronic sinusitis (HP:0011109)	2.39926855
45	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.39501972
46	Midline defect of the nose (HP:0004122)	2.39156140
47	Chromsome breakage (HP:0040012)	2.37522568
48	Abnormality of the corticospinal tract (HP:0002492)	2.36819186
49	True hermaphroditism (HP:0010459)	2.36174728
50	Tubulointerstitial nephritis (HP:0001970)	2.34866780
51	Abdominal situs inversus (HP:0003363)	2.34449925
52	Abnormality of abdominal situs (HP:0011620)	2.34449925
53	Chronic hepatic failure (HP:0100626)	2.32859181
54	Medial flaring of the eyebrow (HP:0010747)	2.32856881
55	Abnormal umbilical cord blood vessels (HP:0011403)	2.32247398
56	Single umbilical artery (HP:0001195)	2.32247398
57	Abnormality of the fetal cardiovascular system (HP:0010948)	2.32247398
58	Male pseudohermaphroditism (HP:0000037)	2.31813875
59	Deformed sella turcica (HP:0002681)	2.31327500
60	Thyroid carcinoma (HP:0002890)	2.25463967
61	Action tremor (HP:0002345)	2.22731830
62	Abnormality of molar morphology (HP:0011070)	2.21355663
63	Abnormality of molar (HP:0011077)	2.21355663
64	Bicornuate uterus (HP:0000813)	2.20425060
65	Abnormality of the distal phalanges of the toes (HP:0010182)	2.16772570
66	Cystic liver disease (HP:0006706)	2.15672332
67	Spinal cord lesions (HP:0100561)	2.10389543
68	Syringomyelia (HP:0003396)	2.10389543
69	Pancreatic fibrosis (HP:0100732)	2.06953844
70	Abnormality of the dental pulp (HP:0006479)	2.06713874
71	Abnormality of the nasal mucosa (HP:0000433)	2.05920182
72	Abnormality of dentin (HP:0010299)	2.04689394
73	Enlarged penis (HP:0000040)	2.02493925
74	Abnormal number of erythroid precursors (HP:0012131)	2.01220382
75	Vaginal atresia (HP:0000148)	2.00419533
76	Pili torti (HP:0003777)	1.99936786
77	Genital tract atresia (HP:0001827)	1.98549758
78	Cutaneous melanoma (HP:0012056)	1.95350894
79	Infertility (HP:0000789)	1.91421337
80	Nonprogressive disorder (HP:0003680)	1.85896810
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85691908
82	Meningioma (HP:0002858)	1.82082873
83	Lower limb asymmetry (HP:0100559)	1.79729362
84	Short middle phalanx of the 5th finger (HP:0004220)	1.76583288
85	Micronodular cirrhosis (HP:0001413)	1.75298540
86	Pancreatic cysts (HP:0001737)	1.75231919
87	Furrowed tongue (HP:0000221)	1.75009110
88	Birth length less than 3rd percentile (HP:0003561)	1.74176705
89	Bifid tongue (HP:0010297)	1.73140313
90	Oculomotor apraxia (HP:0000657)	1.73048326
91	High pitched voice (HP:0001620)	1.72829124
92	Congenital glaucoma (HP:0001087)	1.72459843
93	Preaxial hand polydactyly (HP:0001177)	1.71993779
94	Sclerocornea (HP:0000647)	1.70355069
95	Anencephaly (HP:0002323)	1.70350396
96	Abnormality of cells of the erythroid lineage (HP:0012130)	1.69585057
97	Long toe (HP:0010511)	1.69437109
98	Postaxial foot polydactyly (HP:0001830)	1.68285200
99	Short 5th finger (HP:0009237)	1.67391268
100	Osteomalacia (HP:0002749)	1.66919235

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	6.05384037
2	PKN2	4.88541720
3	MAP3K12	4.83428221
4	CCNB1	3.82780734
5	PNCK	2.86592880
6	MAPKAPK3	2.64178100
7	RPS6KB2	2.43365782
8	SCYL2	2.29809409
9	ILK	2.08509263
10	RPS6KA2	2.06021186
11	PIK3CA	1.97524768
12	MYLK	1.96555363
13	TESK1	1.85678474
14	TTK	1.84244394
15	STK38L	1.79299245
16	MAP3K10	1.77098785
17	PAK4	1.76916537
18	DMPK	1.74823615
19	EEF2K	1.68469481
20	RPS6KL1	1.67267352
21	RPS6KC1	1.67267352
22	FGFR2	1.59068794
23	NME2	1.53694134
24	STK16	1.51654246
25	PASK	1.49839363
26	MUSK	1.49765053
27	CDK7	1.49378732
28	NEK6	1.48871279
29	RPS6KA6	1.46527102
30	STK39	1.43989971
31	AURKA	1.37990148
32	AKT2	1.34338942
33	DYRK3	1.26403313
34	RPS6KB1	1.24995512
35	RET	1.22497016
36	IKBKE	1.16243354
37	FGFR4	1.16009058
38	SIK3	1.04594801
39	LRRK2	1.02616593
40	TESK2	1.02231608
41	TRIM28	0.99469359
42	PTK6	0.98742093
43	CHUK	0.96720642
44	PTK2B	0.94628773
45	TYRO3	0.89355409
46	CDK8	0.89124982
47	MAP3K2	0.88908979
48	MAP2K2	0.88391061
49	TRPM7	0.83791785
50	LIMK1	0.83231197
51	PLK4	0.79527269
52	PBK	0.79412906
53	RPS6KA1	0.77253029
54	TAOK1	0.73066849
55	EIF2AK1	0.66326762
56	DAPK1	0.64073139
57	CAMKK1	0.62182158
58	WEE1	0.60489116
59	PDGFRA	0.59557131
60	MAPKAPK2	0.58945520
61	GRK6	0.58730615
62	PRKCI	0.56546446
63	MAPK15	0.54535039
64	KSR1	0.51604353
65	DAPK3	0.50661089
66	WNK4	0.50657192
67	EIF2AK3	0.49967666
68	STK38	0.47069635
69	MAP2K1	0.43731379
70	AURKB	0.40088871
71	PINK1	0.39993657
72	IRAK3	0.39232949
73	CHEK2	0.39086921
74	ATR	0.36498942
75	NTRK3	0.36412469
76	PLK1	0.33828734
77	CSNK1G2	0.33028159
78	MTOR	0.32571036
79	TSSK6	0.32404182
80	KSR2	0.31761093
81	LATS1	0.31066393
82	EPHA2	0.30955594
83	ACVR1B	0.30315409
84	CHEK1	0.29955723
85	PRKD1	0.25977052
86	ERBB3	0.24224399
87	CSNK2A1	0.23473555
88	MAPK4	0.23411970
89	BCR	0.21706418
90	MST4	0.21522626
91	YES1	0.19899233
92	TTN	0.19190261
93	CAMK1G	0.18354207
94	IRAK2	0.18254955
95	TBK1	0.17751184
96	CDK3	0.17331515
97	ATM	0.16851766
98	AKT1	0.15383298
99	PDGFRB	0.14976563
100	CSNK2A2	0.14721795

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Huntingtons disease_Homo sapiens_hsa05016	2.36996122
2	Ribosome_Homo sapiens_hsa03010	2.32883575
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.15387432
4	Prostate cancer_Homo sapiens_hsa05215	2.07128795
5	Phenylalanine metabolism_Homo sapiens_hsa00360	2.05540036
6	Endometrial cancer_Homo sapiens_hsa05213	2.03275942
7	Proteasome_Homo sapiens_hsa03050	1.92432272
8	Thyroid cancer_Homo sapiens_hsa05216	1.87890228
9	mTOR signaling pathway_Homo sapiens_hsa04150	1.86907365
10	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.84520987
11	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.82891312
12	DNA replication_Homo sapiens_hsa03030	1.75354451
13	Acute myeloid leukemia_Homo sapiens_hsa05221	1.74976317
14	AMPK signaling pathway_Homo sapiens_hsa04152	1.74618361
15	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.71426304
16	Estrogen signaling pathway_Homo sapiens_hsa04915	1.70121027
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.69626336
18	RNA transport_Homo sapiens_hsa03013	1.69138465
19	Prolactin signaling pathway_Homo sapiens_hsa04917	1.68390582
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.62038128
21	Melanoma_Homo sapiens_hsa05218	1.59362127
22	Non-small cell lung cancer_Homo sapiens_hsa05223	1.55560440
23	mRNA surveillance pathway_Homo sapiens_hsa03015	1.54983596
24	RNA polymerase_Homo sapiens_hsa03020	1.54620508
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.53985025
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.51676691
27	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.47050743
28	Renal cell carcinoma_Homo sapiens_hsa05211	1.45131064
29	Mismatch repair_Homo sapiens_hsa03430	1.45031822
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.42860701
31	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.41437493
32	Glutathione metabolism_Homo sapiens_hsa00480	1.40596354
33	Glioma_Homo sapiens_hsa05214	1.32836396
34	Parkinsons disease_Homo sapiens_hsa05012	1.28804786
35	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.27567841
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26156297
37	ErbB signaling pathway_Homo sapiens_hsa04012	1.25942992
38	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.25495630
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.22730617
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22224201
41	Spliceosome_Homo sapiens_hsa03040	1.19266261
42	Choline metabolism in cancer_Homo sapiens_hsa05231	1.18395262
43	Sulfur relay system_Homo sapiens_hsa04122	1.17482693
44	Base excision repair_Homo sapiens_hsa03410	1.12654302
45	VEGF signaling pathway_Homo sapiens_hsa04370	1.07198883
46	Pancreatic cancer_Homo sapiens_hsa05212	1.06447543
47	Cell cycle_Homo sapiens_hsa04110	1.05998279
48	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.04995434
49	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.04216455
50	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01872547
51	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.00139702
52	Tight junction_Homo sapiens_hsa04530	0.97921575
53	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.94311214
54	Bladder cancer_Homo sapiens_hsa05219	0.91981190
55	Colorectal cancer_Homo sapiens_hsa05210	0.91603483
56	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.88656912
57	Regulation of autophagy_Homo sapiens_hsa04140	0.88514049
58	Alzheimers disease_Homo sapiens_hsa05010	0.87722750
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.86543289
60	Basal transcription factors_Homo sapiens_hsa03022	0.82377152
61	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.79130783
62	Vibrio cholerae infection_Homo sapiens_hsa05110	0.78407410
63	Homologous recombination_Homo sapiens_hsa03440	0.77731543
64	Hippo signaling pathway_Homo sapiens_hsa04390	0.77716267
65	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.77490394
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.76708416
67	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.74502337
68	Notch signaling pathway_Homo sapiens_hsa04330	0.74022278
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.73842693
70	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.73241048
71	RNA degradation_Homo sapiens_hsa03018	0.72953580
72	Pentose phosphate pathway_Homo sapiens_hsa00030	0.71917402
73	Insulin signaling pathway_Homo sapiens_hsa04910	0.70879031
74	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68881098
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.66620903
76	Hepatitis B_Homo sapiens_hsa05161	0.65951360
77	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63739573
78	Type II diabetes mellitus_Homo sapiens_hsa04930	0.57446350
79	Purine metabolism_Homo sapiens_hsa00230	0.57167285
80	Insulin resistance_Homo sapiens_hsa04931	0.55759362
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.54464607
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54199587
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.52029636
84	Glucagon signaling pathway_Homo sapiens_hsa04922	0.51761113
85	Melanogenesis_Homo sapiens_hsa04916	0.51551512
86	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.51066480
87	Folate biosynthesis_Homo sapiens_hsa00790	0.49788458
88	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.49486990
89	HTLV-I infection_Homo sapiens_hsa05166	0.48830547
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47878244
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47843305
92	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.47816886
93	Proteoglycans in cancer_Homo sapiens_hsa05205	0.47721958
94	Cholinergic synapse_Homo sapiens_hsa04725	0.47074105
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.47015280
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.46642497
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.43629902
98	Oocyte meiosis_Homo sapiens_hsa04114	0.42991424
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.40393378
100	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.39371715

RHOXF1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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