RHOXF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, which encodes a transcriptional repressor, is one of two paralogous X-linked homeobox-containing genes and is highly expressed in a variety of cancers. In addition, the encoded protein associates with the cell membrane and with microtubules, and is concentrated at the leading edge of migratory cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.03014186
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.95121414
3synapsis (GO:0007129)5.78088623
4DNA replication checkpoint (GO:0000076)5.59157027
5nuclear pore organization (GO:0006999)5.37786915
6regulation of translational fidelity (GO:0006450)5.20175414
7regulation of retinoic acid receptor signaling pathway (GO:0048385)4.90615702
8resolution of meiotic recombination intermediates (GO:0000712)4.83775461
9diterpenoid biosynthetic process (GO:0016102)4.75058281
10DNA replication initiation (GO:0006270)4.73257897
11mitotic nuclear envelope disassembly (GO:0007077)4.63730694
12terpenoid biosynthetic process (GO:0016114)4.53052059
13pore complex assembly (GO:0046931)4.47986314
14formation of translation preinitiation complex (GO:0001731)4.27240378
15membrane disassembly (GO:0030397)4.26875688
16nuclear envelope disassembly (GO:0051081)4.26875688
17mitotic sister chromatid segregation (GO:0000070)4.21889376
18DNA unwinding involved in DNA replication (GO:0006268)4.12765513
19gas transport (GO:0015669)4.09059163
20maturation of 5.8S rRNA (GO:0000460)4.06653729
21sister chromatid segregation (GO:0000819)3.99231938
22proteasome assembly (GO:0043248)3.94942623
23meiotic chromosome segregation (GO:0045132)3.94674425
24regulation of histone H3-K4 methylation (GO:0051569)3.92581853
25oxidative phosphorylation (GO:0006119)3.90878032
26protoporphyrinogen IX metabolic process (GO:0046501)3.79289034
27oxygen transport (GO:0015671)3.79012371
28DNA topological change (GO:0006265)3.71409380
29DNA methylation involved in gamete generation (GO:0043046)3.70909864
30regulation of translational elongation (GO:0006448)3.69022092
31DNA strand elongation involved in DNA replication (GO:0006271)3.55684613
32vitamin A metabolic process (GO:0006776)3.55591679
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53400811
34regulation of histone H3-K27 methylation (GO:0061085)3.48063874
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47720033
36DNA strand elongation (GO:0022616)3.46069359
37protoporphyrinogen IX biosynthetic process (GO:0006782)3.45804940
38intra-S DNA damage checkpoint (GO:0031573)3.41217780
39regulation of mitotic spindle organization (GO:0060236)3.40039743
40tRNA aminoacylation for protein translation (GO:0006418)3.37537669
41telomere maintenance via semi-conservative replication (GO:0032201)3.36652637
42regulation of RNA export from nucleus (GO:0046831)3.36318220
43transcription from mitochondrial promoter (GO:0006390)3.35726014
44erythrocyte maturation (GO:0043249)3.34482276
45chromosome organization involved in meiosis (GO:0070192)3.31409128
46regulation of DNA endoreduplication (GO:0032875)3.30966850
47rRNA methylation (GO:0031167)3.29761561
48rRNA modification (GO:0000154)3.28442374
49tRNA aminoacylation (GO:0043039)3.27207246
50amino acid activation (GO:0043038)3.27207246
51folic acid-containing compound biosynthetic process (GO:0009396)3.25780346
52purine nucleobase biosynthetic process (GO:0009113)3.23155286
53ribosome biogenesis (GO:0042254)3.21980586
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21842425
55negative regulation of protein acetylation (GO:1901984)3.14281410
56homocysteine metabolic process (GO:0050667)3.12654184
57chromosome segregation (GO:0007059)3.12312198
58mitotic chromosome condensation (GO:0007076)3.11458678
59nuclear envelope organization (GO:0006998)3.09797025
60IMP biosynthetic process (GO:0006188)3.09101381
61ribosome assembly (GO:0042255)3.06877055
62gonadal mesoderm development (GO:0007506)3.06297432
63microtubule depolymerization (GO:0007019)3.05957952
64telomere maintenance via recombination (GO:0000722)2.99679894
65mitotic recombination (GO:0006312)2.99015816
66male meiosis I (GO:0007141)2.98558828
67nucleobase biosynthetic process (GO:0046112)2.98312566
68response to vitamin A (GO:0033189)2.97211783
69tetrahydrofolate metabolic process (GO:0046653)2.95241350
70regulation of centrosome cycle (GO:0046605)2.91076158
71sensory perception of smell (GO:0007608)2.90142193
72energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88735667
73ATP synthesis coupled proton transport (GO:0015986)2.88735667
74male meiosis (GO:0007140)2.87319685
75erythrocyte development (GO:0048821)2.87219042
76ribosomal large subunit biogenesis (GO:0042273)2.85365545
77ribonucleoprotein complex biogenesis (GO:0022613)2.84333289
78mitotic metaphase plate congression (GO:0007080)2.83919623
79CENP-A containing nucleosome assembly (GO:0034080)2.81830289
80regulation of histone methylation (GO:0031060)2.81653522
81proline biosynthetic process (GO:0006561)2.79167648
82mitochondrial RNA metabolic process (GO:0000959)2.78730185
83detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.78003881
84DNA catabolic process, exonucleolytic (GO:0000738)2.77837120
85pseudouridine synthesis (GO:0001522)2.77570616
86DNA replication-independent nucleosome organization (GO:0034724)2.77448727
87DNA replication-independent nucleosome assembly (GO:0006336)2.77448727
88positive regulation of histone H3-K4 methylation (GO:0051571)2.76217472
89viral mRNA export from host cell nucleus (GO:0046784)2.76186521
90definitive hemopoiesis (GO:0060216)2.75858146
91kinetochore organization (GO:0051383)2.75469008
92succinate metabolic process (GO:0006105)2.72007589
93telomere maintenance via telomere lengthening (GO:0010833)2.70946710
94isoprenoid biosynthetic process (GO:0008299)2.70371734
95granulocyte differentiation (GO:0030851)2.68529855
96N-terminal protein amino acid acetylation (GO:0006474)2.67428408
97regulation of double-strand break repair via homologous recombination (GO:0010569)2.66013645
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.65688012
99rRNA catabolic process (GO:0016075)2.64745590
100regulation of spindle organization (GO:0090224)2.63485051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.38820096
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.17956012
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80243697
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.58000978
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.48318951
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.29371199
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24153347
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09934106
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05153317
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.97155098
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.95301598
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94634278
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72318930
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65145926
15NCOR1_26117541_ChIP-Seq_K562_Human2.44955128
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44189790
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33022371
18XRN2_22483619_ChIP-Seq_HELA_Human2.31093582
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30207292
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21141519
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13400851
22TTF2_22483619_ChIP-Seq_HELA_Human2.11170939
23ELK1_19687146_ChIP-ChIP_HELA_Human2.05195793
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04861191
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.01981404
26FOXP3_21729870_ChIP-Seq_TREG_Human1.99423804
27GATA1_19941826_ChIP-Seq_K562_Human1.98866751
28VDR_23849224_ChIP-Seq_CD4+_Human1.96076764
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95053452
30DCP1A_22483619_ChIP-Seq_HELA_Human1.94513996
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91407498
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90551909
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88996271
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87008854
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.86655698
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.85258424
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84568406
38AR_21909140_ChIP-Seq_LNCAP_Human1.79631153
39CIITA_25753668_ChIP-Seq_RAJI_Human1.78810060
40KDM5A_27292631_Chip-Seq_BREAST_Human1.77778688
41GABP_19822575_ChIP-Seq_HepG2_Human1.77193339
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72720759
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70102340
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67603681
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66511532
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65061253
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56160785
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55755751
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54505121
50VDR_22108803_ChIP-Seq_LS180_Human1.51228391
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44464541
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.42737839
53GATA2_19941826_ChIP-Seq_K562_Human1.42582256
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41437447
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37871119
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30858057
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29734539
58MYC_18940864_ChIP-ChIP_HL60_Human1.29047511
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28126096
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27820227
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24564175
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24247952
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22128230
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22072058
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21289886
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19980023
67PHF8_20622853_ChIP-Seq_HELA_Human1.12909782
68GATA6_21074721_ChIP-Seq_CACO-2_Human1.11342839
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11133323
70CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06820572
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04929296
72ZNF263_19887448_ChIP-Seq_K562_Human1.03335755
73RBPJ_21746931_ChIP-Seq_IB4_Human1.02755608
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01744953
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98998455
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97799739
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97773175
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97036233
79ETV1_20927104_ChIP-Seq_GIST48_Human0.96603531
80SALL1_21062744_ChIP-ChIP_HESCs_Human0.96585741
81KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96271069
82STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94427680
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94064385
84GATA1_22025678_ChIP-Seq_K562_Human0.93969539
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93892903
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92946292
87HNFA_21074721_ChIP-Seq_CACO-2_Human0.92634842
88SCL_19346495_ChIP-Seq_HPC-7_Human0.91514831
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91366339
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90984599
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90569746
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84609925
93NFYB_21822215_ChIP-Seq_K562_Human0.84226602
94CBX2_22325352_ChIP-Seq_293T-Rex_Human0.84154852
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82770934
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81962267
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80446332
98TFEB_21752829_ChIP-Seq_HELA_Human0.79646845
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78827846
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78668182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.40295270
2MP0008995_early_reproductive_senescence4.27581352
3MP0004957_abnormal_blastocyst_morpholog3.98164213
4MP0003111_abnormal_nucleus_morphology3.53863023
5MP0008058_abnormal_DNA_repair3.48787571
6MP0010094_abnormal_chromosome_stability3.45601957
7MP0003693_abnormal_embryo_hatching3.41295585
8MP0000678_abnormal_parathyroid_gland2.90088641
9MP0003786_premature_aging2.89445494
10MP0003718_maternal_effect2.74197098
11MP0009697_abnormal_copulation2.65672039
12MP0008932_abnormal_embryonic_tissue2.58374991
13MP0004145_abnormal_muscle_electrophysio2.46377509
14MP0006292_abnormal_olfactory_placode2.45016638
15MP0006036_abnormal_mitochondrial_physio2.36753224
16MP0002132_abnormal_respiratory_system2.34934864
17MP0008057_abnormal_DNA_replication2.24037555
18MP0006035_abnormal_mitochondrial_morpho2.19943511
19MP0008007_abnormal_cellular_replicative2.17924517
20MP0003077_abnormal_cell_cycle2.16233658
21MP0005083_abnormal_biliary_tract1.99650190
22MP0005646_abnormal_pituitary_gland1.92272263
23MP0002210_abnormal_sex_determination1.85974167
24MP0000372_irregular_coat_pigmentation1.84226934
25MP0003646_muscle_fatigue1.80615931
26MP0001661_extended_life_span1.77495689
27MP0003656_abnormal_erythrocyte_physiolo1.77280836
28MP0001929_abnormal_gametogenesis1.72856177
29MP0001697_abnormal_embryo_size1.65543126
30MP0005397_hematopoietic_system_phenotyp1.53915720
31MP0001545_abnormal_hematopoietic_system1.53915720
32MP0001730_embryonic_growth_arrest1.48458516
33MP0010307_abnormal_tumor_latency1.46882468
34MP0002160_abnormal_reproductive_system1.45815744
35MP0008877_abnormal_DNA_methylation1.38786779
36MP0000653_abnormal_sex_gland1.33372346
37MP0001145_abnormal_male_reproductive1.32383876
38MP0000350_abnormal_cell_proliferation1.30950724
39MP0005451_abnormal_body_composition1.28140439
40MP0005380_embryogenesis_phenotype1.22364335
41MP0001672_abnormal_embryogenesis/_devel1.22364335
42MP0002080_prenatal_lethality1.19564275
43MP0003698_abnormal_male_reproductive1.19496020
44MP0000313_abnormal_cell_death1.18979459
45MP0005410_abnormal_fertilization1.16541286
46MP0008775_abnormal_heart_ventricle1.15164843
47MP0003186_abnormal_redox_activity1.15099893
48MP0005389_reproductive_system_phenotype1.12923195
49MP0005171_absent_coat_pigmentation1.12765921
50MP0005636_abnormal_mineral_homeostasis1.09494937
51MP0002396_abnormal_hematopoietic_system1.09278891
52MP0003984_embryonic_growth_retardation1.07224325
53MP0002088_abnormal_embryonic_growth/wei1.06043586
54MP0003938_abnormal_ear_development1.02659218
55MP0002086_abnormal_extraembryonic_tissu1.01353163
56MP0003806_abnormal_nucleotide_metabolis0.98876782
57MP0003699_abnormal_female_reproductive0.97624020
58MP0004134_abnormal_chest_morphology0.96819572
59MP0000358_abnormal_cell_content/0.96239992
60MP0003136_yellow_coat_color0.95754347
61MP0003567_abnormal_fetal_cardiomyocyte0.95722499
62MP0001727_abnormal_embryo_implantation0.95453420
63MP0000631_abnormal_neuroendocrine_gland0.95412190
64MP0002249_abnormal_larynx_morphology0.93033587
65MP0003959_abnormal_lean_body0.92178800
66MP0001764_abnormal_homeostasis0.91723919
67MP0002161_abnormal_fertility/fecundity0.91711904
68MP0001119_abnormal_female_reproductive0.89420396
69MP0002084_abnormal_developmental_patter0.89128644
70MP0005670_abnormal_white_adipose0.87834012
71MP0009278_abnormal_bone_marrow0.86353948
72MP0003890_abnormal_embryonic-extraembry0.86199937
73MP0002085_abnormal_embryonic_tissue0.84733439
74MP0003942_abnormal_urinary_system0.84591198
75MP0002139_abnormal_hepatobiliary_system0.81626020
76MP0004233_abnormal_muscle_weight0.77942601
77MP0003937_abnormal_limbs/digits/tail_de0.77354035
78MP0001529_abnormal_vocalization0.74983267
79MP0000647_abnormal_sebaceous_gland0.74070259
80MP0002837_dystrophic_cardiac_calcinosis0.73663891
81MP0003123_paternal_imprinting0.71730126
82MP0008770_decreased_survivor_rate0.71635521
83MP0002019_abnormal_tumor_incidence0.69831592
84MP0005332_abnormal_amino_acid0.69225774
85MP0006276_abnormal_autonomic_nervous0.68806032
86MP0005645_abnormal_hypothalamus_physiol0.68622383
87MP0001881_abnormal_mammary_gland0.67432823
88MP0000681_abnormal_thyroid_gland0.67389480
89MP0005408_hypopigmentation0.67319058
90MP0003936_abnormal_reproductive_system0.66692345
91MP0003385_abnormal_body_wall0.65113952
92MP0003119_abnormal_digestive_system0.64994924
93MP0008789_abnormal_olfactory_epithelium0.64563623
94MP0004019_abnormal_vitamin_homeostasis0.61361735
95MP0000703_abnormal_thymus_morphology0.61027994
96MP0002269_muscular_atrophy0.60563396
97MP0005395_other_phenotype0.59962724
98MP0001986_abnormal_taste_sensitivity0.59571073
99MP0001502_abnormal_circadian_rhythm0.58338692
100MP0004808_abnormal_hematopoietic_stem0.58258937

Predicted human phenotypes

RankGene SetZ-score
1Truncus arteriosus (HP:0001660)6.12419329
2Abnormal gallbladder physiology (HP:0012438)5.77130090
3Cholecystitis (HP:0001082)5.77130090
4Hyperthyroidism (HP:0000836)5.38541240
5Reticulocytosis (HP:0001923)4.74989801
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.57354214
7Chromsome breakage (HP:0040012)4.51044056
8Abnormality of reticulocytes (HP:0004312)4.30270455
9Birth length less than 3rd percentile (HP:0003561)3.96652884
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.76993938
11Abnormal hemoglobin (HP:0011902)3.70944361
12Abnormality of cochlea (HP:0000375)3.59039396
13Polycythemia (HP:0001901)3.47863266
14Bowel incontinence (HP:0002607)3.36524022
15Reticulocytopenia (HP:0001896)3.35862946
16Abnormality of glycolysis (HP:0004366)3.33647608
17Increased serum pyruvate (HP:0003542)3.33071743
18Ankyloglossia (HP:0010296)3.31408995
19Abnormality of homocysteine metabolism (HP:0010919)3.28962258
20Homocystinuria (HP:0002156)3.28962258
21Duplicated collecting system (HP:0000081)3.26133050
22Acute encephalopathy (HP:0006846)3.23779346
23Abnormal large intestine physiology (HP:0012700)3.23029954
24Abnormality of the renal collecting system (HP:0004742)3.15912626
25Seborrheic dermatitis (HP:0001051)3.15115578
26Ileus (HP:0002595)3.13557199
27Hypertensive crisis (HP:0100735)3.12238534
28Poikilocytosis (HP:0004447)3.11413177
29Pallor (HP:0000980)3.06226508
30Abnormality of the tricuspid valve (HP:0001702)2.84265508
31Acute necrotizing encephalopathy (HP:0006965)2.80067419
32Abnormal mitochondria in muscle tissue (HP:0008316)2.72344732
33Hypoparathyroidism (HP:0000829)2.71992367
34Morphological abnormality of the inner ear (HP:0011390)2.68788804
35Cholelithiasis (HP:0001081)2.65956455
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.65054644
37Acanthocytosis (HP:0001927)2.60848515
38Acute myeloid leukemia (HP:0004808)2.60615117
39Cortical dysplasia (HP:0002539)2.60197753
40Abnormality of DNA repair (HP:0003254)2.58934223
41Abnormality of the preputium (HP:0100587)2.50705952
42Small intestinal stenosis (HP:0012848)2.49718330
43Duodenal stenosis (HP:0100867)2.49718330
44Ectopic kidney (HP:0000086)2.45583054
45Atelectasis (HP:0100750)2.39277423
46Abnormal gallbladder morphology (HP:0012437)2.37298755
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.35940731
48Myelodysplasia (HP:0002863)2.34917586
49Tinnitus (HP:0000360)2.33965031
50Abnormal number of erythroid precursors (HP:0012131)2.33389087
51Increased CSF lactate (HP:0002490)2.30077190
52Aplasia/Hypoplasia of the earlobes (HP:0009906)2.29962420
53Hyperbilirubinemia (HP:0002904)2.28482435
54Horseshoe kidney (HP:0000085)2.28292500
55Limb hypertonia (HP:0002509)2.27482714
56Male infertility (HP:0003251)2.27451402
57Abnormality of cells of the erythroid lineage (HP:0012130)2.27179035
58Progressive macrocephaly (HP:0004481)2.23970058
59Ureteral duplication (HP:0000073)2.22117736
60Abnormal lung lobation (HP:0002101)2.18430883
61Upper limb muscle weakness (HP:0003484)2.17392939
62Abnormality of oral frenula (HP:0000190)2.11731547
63Cerebral edema (HP:0002181)2.10105152
64Meckel diverticulum (HP:0002245)2.08796155
65Abnormality of the carotid arteries (HP:0005344)2.08766381
66Abnormality of chromosome stability (HP:0003220)2.04846703
67Premature ovarian failure (HP:0008209)2.04799306
68Abnormality of the ileum (HP:0001549)2.00962798
69Abnormally folded helix (HP:0008544)1.98944301
70Increased serum lactate (HP:0002151)1.95351403
71Mitochondrial inheritance (HP:0001427)1.94254514
72Absent thumb (HP:0009777)1.93859202
73Pancytopenia (HP:0001876)1.90483195
74Abnormality of the duodenum (HP:0002246)1.90288269
75Aplasia/Hypoplasia of the thymus (HP:0010515)1.89915926
76Abnormality of the gallbladder (HP:0005264)1.89131511
77Increased nuchal translucency (HP:0010880)1.86039167
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85923046
79Abnormality of alanine metabolism (HP:0010916)1.85923046
80Hyperalaninemia (HP:0003348)1.85923046
81Redundant skin (HP:0001582)1.83787042
82Nonimmune hydrops fetalis (HP:0001790)1.81694599
83Short middle phalanx of the 5th finger (HP:0004220)1.81639954
84Hypoplasia of the pons (HP:0012110)1.81216115
85Abnormality of the pons (HP:0007361)1.81016370
86Flat cornea (HP:0007720)1.79568379
87Cheekbone underdevelopment (HP:0010669)1.77893610
88Spinal muscular atrophy (HP:0007269)1.77540121
89Cerebral hypomyelination (HP:0006808)1.77098226
90Palpitations (HP:0001962)1.76077305
91Abnormality of the anterior horn cell (HP:0006802)1.75318493
92Degeneration of anterior horn cells (HP:0002398)1.75318493
93Sandal gap (HP:0001852)1.73178367
94Submucous cleft hard palate (HP:0000176)1.73017636
95Lactic acidosis (HP:0003128)1.71008820
96Abnormality of the labia minora (HP:0012880)1.64016803
97Increased hepatocellular lipid droplets (HP:0006565)1.63814405
98Aplastic anemia (HP:0001915)1.63693244
99Secondary amenorrhea (HP:0000869)1.62893805
100Macrocytic anemia (HP:0001972)1.62025286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.74493058
2BUB13.84943646
3RIPK43.42597119
4TTK3.33209837
5CLK13.15763218
6KSR22.88115857
7EIF2AK32.78411176
8STK162.75012089
9CDC72.58505444
10NTRK32.52636979
11PLK42.46086504
12RAF12.39810295
13WEE12.29782330
14MAP3K22.18752617
15NME12.17435532
16BMPR22.14346549
17BRSK22.08801275
18NEK12.05880897
19SRPK11.87697457
20TSSK61.70212048
21EEF2K1.64241519
22WNK41.64219601
23CCNB11.61243213
24NEK21.59728009
25MKNK21.51731925
26PDK21.47938262
27MAP3K81.41282101
28MKNK11.40097904
29KSR11.38384589
30MST41.26637403
31CHEK21.21946219
32BRSK11.21387308
33PLK31.19648651
34PLK11.17126137
35PBK1.16930786
36STK31.14019822
37ATR1.13136277
38ACVR1B1.12519229
39PLK21.09651707
40MAP2K11.02933078
41CHEK10.97383523
42BMX0.95614370
43MAP3K40.94952793
44STK40.87687233
45STK390.85393341
46ATM0.81864028
47CDK10.79841670
48ALK0.77966391
49CDK20.75047519
50PAK10.72952939
51NUAK10.70250610
52WNK10.70191760
53AURKB0.69493947
54IRAK30.65424803
55ICK0.64932972
56BRAF0.64843746
57NME20.64335249
58AURKA0.63745865
59ZAK0.63489180
60EIF2AK20.62904377
61RPS6KB20.62491555
62TEC0.60907700
63CSNK2A20.60678532
64CSNK2A10.59353601
65JAK20.57198380
66DYRK30.56824149
67RPS6KA50.56776554
68MAPKAPK50.54633995
69TRPM70.53955972
70CSNK1E0.53535515
71MAP2K20.49432633
72CDK120.48206628
73MAPKAPK30.48080965
74OXSR10.46981179
75PIM10.45512676
76SGK10.43144461
77BRD40.42456561
78PTK60.41663700
79STK100.40585682
80SCYL20.39206104
81TAOK30.36558860
82CDK70.34350761
83GSK3B0.33890053
84MARK30.33021564
85RET0.32915695
86MAPK140.32900403
87PRKDC0.31455943
88RPS6KA40.30783949
89JAK30.28438531
90PIK3CG0.28075107
91DMPK0.27490227
92MAPK100.27428159
93ILK0.27262701
94MTOR0.26255193
95MAPK130.25812662
96TLK10.25677998
97BTK0.24878874
98MATK0.24753967
99MAPK30.24475080
100PASK0.24288218

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.77229688
2DNA replication_Homo sapiens_hsa030303.55001433
3Mismatch repair_Homo sapiens_hsa034303.42622079
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26559082
5Homologous recombination_Homo sapiens_hsa034403.21891944
6One carbon pool by folate_Homo sapiens_hsa006703.17786250
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.97040877
8RNA transport_Homo sapiens_hsa030132.88181616
9Ribosome_Homo sapiens_hsa030102.51904499
10Spliceosome_Homo sapiens_hsa030402.50515733
11Fanconi anemia pathway_Homo sapiens_hsa034602.36181542
12Basal transcription factors_Homo sapiens_hsa030222.23011412
13RNA polymerase_Homo sapiens_hsa030202.20471780
14Cell cycle_Homo sapiens_hsa041102.13008705
15Proteasome_Homo sapiens_hsa030502.07012697
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.04309678
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96913968
18RNA degradation_Homo sapiens_hsa030181.93101135
19Nucleotide excision repair_Homo sapiens_hsa034201.92827421
20Parkinsons disease_Homo sapiens_hsa050121.91174938
21Oxidative phosphorylation_Homo sapiens_hsa001901.80353947
22mRNA surveillance pathway_Homo sapiens_hsa030151.73069517
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71187617
24Steroid biosynthesis_Homo sapiens_hsa001001.59281774
25Pyruvate metabolism_Homo sapiens_hsa006201.54597636
26Propanoate metabolism_Homo sapiens_hsa006401.49865652
27Huntingtons disease_Homo sapiens_hsa050161.47090606
28Base excision repair_Homo sapiens_hsa034101.44210068
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.43774741
30Pyrimidine metabolism_Homo sapiens_hsa002401.38534820
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37870064
32Olfactory transduction_Homo sapiens_hsa047401.35175971
33Carbon metabolism_Homo sapiens_hsa012001.31925927
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31715198
35Oocyte meiosis_Homo sapiens_hsa041141.30294010
36Selenocompound metabolism_Homo sapiens_hsa004501.28586578
37Non-homologous end-joining_Homo sapiens_hsa034501.28175455
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.28010310
39Protein export_Homo sapiens_hsa030601.27773145
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14746937
41Biosynthesis of amino acids_Homo sapiens_hsa012301.12033215
42Purine metabolism_Homo sapiens_hsa002301.10436969
43Alzheimers disease_Homo sapiens_hsa050101.06838084
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95092953
45Sulfur metabolism_Homo sapiens_hsa009200.90211675
46Butanoate metabolism_Homo sapiens_hsa006500.89873863
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79117413
48Arginine biosynthesis_Homo sapiens_hsa002200.75598215
49Fructose and mannose metabolism_Homo sapiens_hsa000510.70134798
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69297161
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68956644
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65216816
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63723438
54Type II diabetes mellitus_Homo sapiens_hsa049300.63122132
55Metabolic pathways_Homo sapiens_hsa011000.59658741
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59392182
57Acute myeloid leukemia_Homo sapiens_hsa052210.59121285
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54988008
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54919200
60Cardiac muscle contraction_Homo sapiens_hsa042600.54571012
61p53 signaling pathway_Homo sapiens_hsa041150.52934002
62Fatty acid metabolism_Homo sapiens_hsa012120.50742766
63Nicotine addiction_Homo sapiens_hsa050330.50606535
64mTOR signaling pathway_Homo sapiens_hsa041500.48573896
65Nitrogen metabolism_Homo sapiens_hsa009100.48051908
66Thyroid cancer_Homo sapiens_hsa052160.45425529
67Viral carcinogenesis_Homo sapiens_hsa052030.45330566
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44804827
69HIF-1 signaling pathway_Homo sapiens_hsa040660.43263002
70Sulfur relay system_Homo sapiens_hsa041220.42792572
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42234859
72Pentose phosphate pathway_Homo sapiens_hsa000300.41848259
73Fatty acid elongation_Homo sapiens_hsa000620.41714560
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41269569
75Folate biosynthesis_Homo sapiens_hsa007900.39855036
76Vitamin B6 metabolism_Homo sapiens_hsa007500.37663160
77Epstein-Barr virus infection_Homo sapiens_hsa051690.37624214
78N-Glycan biosynthesis_Homo sapiens_hsa005100.36623309
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33898537
80Glutathione metabolism_Homo sapiens_hsa004800.32081134
81Retinol metabolism_Homo sapiens_hsa008300.28515139
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28481606
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26711452
84ErbB signaling pathway_Homo sapiens_hsa040120.26451688
85Dorso-ventral axis formation_Homo sapiens_hsa043200.26084262
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25705290
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24241758
88Chronic myeloid leukemia_Homo sapiens_hsa052200.24117749
89Insulin signaling pathway_Homo sapiens_hsa049100.21918384
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20261287
91Arginine and proline metabolism_Homo sapiens_hsa003300.20160585
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.19225109
93Fat digestion and absorption_Homo sapiens_hsa049750.16169081
94Renal cell carcinoma_Homo sapiens_hsa052110.14783871
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12377116
96MicroRNAs in cancer_Homo sapiens_hsa052060.10231376
97Taste transduction_Homo sapiens_hsa047420.10164983
98VEGF signaling pathway_Homo sapiens_hsa043700.09734530
99Regulation of autophagy_Homo sapiens_hsa041400.03949060
100Phototransduction_Homo sapiens_hsa047440.03449575

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