RHPN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerulus development (GO:0032835)8.82957260
2proline biosynthetic process (GO:0006561)7.46933317
3establishment of apical/basal cell polarity (GO:0035089)6.23844367
4semaphorin-plexin signaling pathway (GO:0071526)5.85329952
5activation of Rac GTPase activity (GO:0032863)5.72844043
6proline metabolic process (GO:0006560)5.66902421
7epithelial cell differentiation involved in kidney development (GO:0035850)5.66127309
8establishment or maintenance of monopolar cell polarity (GO:0061339)5.53859056
9establishment of monopolar cell polarity (GO:0061162)5.53859056
10auditory receptor cell stereocilium organization (GO:0060088)5.41799005
11embryonic process involved in female pregnancy (GO:0060136)5.39972402
12transcription from mitochondrial promoter (GO:0006390)5.21365221
13negative regulation of cell size (GO:0045792)5.13246127
14mannose metabolic process (GO:0006013)4.75170969
15positive regulation of cell adhesion mediated by integrin (GO:0033630)4.69538266
16peptidyl-tyrosine autophosphorylation (GO:0038083)4.65312950
17regulation of glomerular filtration (GO:0003093)4.62407620
18negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.51138581
19replication fork processing (GO:0031297)4.45764193
20regulation of hydrogen peroxide metabolic process (GO:0010310)4.43921183
21ear development (GO:0043583)4.41313466
22planar cell polarity pathway involved in neural tube closure (GO:0090179)4.40513559
23lung epithelium development (GO:0060428)4.29087177
24regulation of ARF GTPase activity (GO:0032312)4.28471158
25regulation of integrin activation (GO:0033623)4.24783376
26positive regulation of protein homooligomerization (GO:0032464)4.23654539
27negative regulation of erythrocyte differentiation (GO:0045647)4.17806222
28endothelial cell chemotaxis (GO:0035767)4.16152886
29protein localization to endosome (GO:0036010)4.13901073
30oxidative demethylation (GO:0070989)4.10083996
31embryonic camera-type eye development (GO:0031076)4.10019738
32positive regulation of p38MAPK cascade (GO:1900745)4.03302071
33positive regulation of histone deacetylation (GO:0031065)3.98362937
34regulation of protein homooligomerization (GO:0032462)3.98055509
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.91011150
36cell-cell junction maintenance (GO:0045217)3.87093791
37renal system process involved in regulation of blood volume (GO:0001977)3.85542960
38histone H4 deacetylation (GO:0070933)3.85189509
39negative regulation of axon guidance (GO:1902668)3.85007389
40cellular response to ATP (GO:0071318)3.76480430
41regulation of female receptivity (GO:0045924)3.75852024
42regulation of axon guidance (GO:1902667)3.75652099
43positive regulation of protein kinase C signaling (GO:0090037)3.74026723
44apoptotic process involved in morphogenesis (GO:0060561)3.72870370
45establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.70669421
46mitochondrion transport along microtubule (GO:0047497)3.70669421
47renal filtration (GO:0097205)3.70296903
48hypotonic response (GO:0006971)3.68841986
49convergent extension (GO:0060026)3.65775667
50positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.62545132
51inner ear receptor stereocilium organization (GO:0060122)3.57050596
52labyrinthine layer development (GO:0060711)3.54619083
53synaptic vesicle docking involved in exocytosis (GO:0016081)3.53519921
54negative regulation of JAK-STAT cascade (GO:0046426)3.49976141
55desmosome organization (GO:0002934)3.48176019
56DNA deamination (GO:0045006)3.46883131
57insulin-like growth factor receptor signaling pathway (GO:0048009)3.42115745
58DNA strand renaturation (GO:0000733)3.40112512
59COPI coating of Golgi vesicle (GO:0048205)3.39627512
60Golgi transport vesicle coating (GO:0048200)3.39627512
61maternal placenta development (GO:0001893)3.39513715
62embryonic placenta development (GO:0001892)3.38954661
63protein heterotrimerization (GO:0070208)3.38569169
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.36300519
65protein kinase C signaling (GO:0070528)3.35268526
66histone H3 deacetylation (GO:0070932)3.33738619
67poly(A)+ mRNA export from nucleus (GO:0016973)3.31594219
68paraxial mesoderm development (GO:0048339)3.30839337
69regulation of histone H3-K27 methylation (GO:0061085)3.29869945
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.26240952
71female mating behavior (GO:0060180)3.18673936
72atrioventricular valve morphogenesis (GO:0003181)3.18453548
73spliceosomal tri-snRNP complex assembly (GO:0000244)3.17002199
74myoblast fusion (GO:0007520)3.16377150
75establishment of mitochondrion localization (GO:0051654)3.15876785
76stress granule assembly (GO:0034063)3.14513322
77establishment or maintenance of bipolar cell polarity (GO:0061245)3.12967730
78establishment or maintenance of apical/basal cell polarity (GO:0035088)3.12967730
79retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12204059
80mitochondrial DNA metabolic process (GO:0032042)3.11760418
81regulation of ruffle assembly (GO:1900027)3.09124036
82dopaminergic neuron differentiation (GO:0071542)3.08715469
83regulation of interleukin-13 production (GO:0032656)3.08013413
84activation of JUN kinase activity (GO:0007257)3.07501703
85face development (GO:0060324)3.07021037
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.06164876
87somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06164876
88stress fiber assembly (GO:0043149)3.04417577
89thymic T cell selection (GO:0045061)3.03237700
90cytoskeletal anchoring at plasma membrane (GO:0007016)3.02311688
91morphogenesis of an epithelial sheet (GO:0002011)3.01637250
92regulation of hippo signaling (GO:0035330)3.01450630
93positive regulation of Cdc42 GTPase activity (GO:0043089)3.00972411
94snRNA metabolic process (GO:0016073)2.99547314
95cell migration involved in sprouting angiogenesis (GO:0002042)2.99520574
96mammary gland epithelial cell differentiation (GO:0060644)2.98915894
97positive regulation of synapse maturation (GO:0090129)2.98358056
98regulation of chromatin binding (GO:0035561)2.98305485
99coronary vasculature morphogenesis (GO:0060977)2.98287342
100kidney mesenchyme development (GO:0072074)2.97306327
101epithelial cell differentiation involved in prostate gland development (GO:0060742)2.97116933
102protein retention in ER lumen (GO:0006621)2.97051608
103regulation of cholesterol biosynthetic process (GO:0045540)2.95097007
104regulation of p38MAPK cascade (GO:1900744)2.93633349
105N-glycan processing (GO:0006491)2.93555462
106Rho protein signal transduction (GO:0007266)2.93208850
107mitotic G1 DNA damage checkpoint (GO:0031571)2.93174186
108positive regulation of protein deacetylation (GO:0090312)2.93015427
109intracellular estrogen receptor signaling pathway (GO:0030520)2.92794293
110renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.91501608
111regulation of fatty acid beta-oxidation (GO:0031998)2.91067151
112histone H3-K9 demethylation (GO:0033169)2.89791350
113adherens junction assembly (GO:0034333)2.89382528
114epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88300941
115motile cilium assembly (GO:0044458)2.87416573
116negative regulation of protein oligomerization (GO:0032460)2.85965866
117regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.83665175
118anterior/posterior axis specification, embryo (GO:0008595)2.82503124
119glutamine family amino acid biosynthetic process (GO:0009084)2.80616195
120cell migration in hindbrain (GO:0021535)2.80534354
121negative regulation of Ras GTPase activity (GO:0034261)2.79261625
122regulation of vascular permeability (GO:0043114)2.77690465
123Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.76946672
124syncytium formation by plasma membrane fusion (GO:0000768)2.76798552
125regulation of endothelial cell chemotaxis (GO:2001026)2.76447850
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.75777879
127phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.75563108
128G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.75462864
129regulation of histone deacetylation (GO:0031063)2.75376947
130regulation of ARF protein signal transduction (GO:0032012)2.74955277
131positive regulation of vascular permeability (GO:0043117)2.74727387
132snRNA processing (GO:0016180)2.72977998
133synaptic vesicle endocytosis (GO:0048488)2.71966068
134glomerular filtration (GO:0003094)2.70601441
135negative regulation of cell cycle arrest (GO:0071157)2.70500902
136glutathione biosynthetic process (GO:0006750)2.70252702
137positive regulation of Rac GTPase activity (GO:0032855)2.69834451
138vascular endothelial growth factor signaling pathway (GO:0038084)2.69357019
139glial cell migration (GO:0008347)2.69230190
140signal complex assembly (GO:0007172)2.68757049
141G1 DNA damage checkpoint (GO:0044783)2.67957337
142cell junction maintenance (GO:0034331)2.66367965
143DNA topological change (GO:0006265)2.66347956
144GDP-mannose metabolic process (GO:0019673)2.64651569
145regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64327304
146regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.64323359
147positive regulation of developmental pigmentation (GO:0048087)2.64264206
148regulation of translational fidelity (GO:0006450)2.63973190
149branching involved in salivary gland morphogenesis (GO:0060445)2.62796890
150regulation of extracellular matrix disassembly (GO:0010715)2.62525140
151dopamine receptor signaling pathway (GO:0007212)2.61400450
152mRNA cleavage (GO:0006379)2.61282576
153regulation of clathrin-mediated endocytosis (GO:2000369)2.60109712
154venous blood vessel morphogenesis (GO:0048845)2.60070819
155maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59949803
156positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.59527591
157embryonic eye morphogenesis (GO:0048048)2.59413960
158apical protein localization (GO:0045176)2.59001437
159diaphragm development (GO:0060539)2.58878317
160positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58699355
161negative regulation of homotypic cell-cell adhesion (GO:0034111)2.58493080
162cell-substrate adherens junction assembly (GO:0007045)2.58277958
163focal adhesion assembly (GO:0048041)2.58277958
164positive regulation of keratinocyte differentiation (GO:0045618)2.57465826
165positive regulation of CREB transcription factor activity (GO:0032793)2.57218371
166regulation of cell proliferation involved in kidney development (GO:1901722)2.57132951
167DNA integration (GO:0015074)2.56216142
168phosphatidylinositol 3-kinase signaling (GO:0014065)2.55327783
169neuronal ion channel clustering (GO:0045161)2.55321903
170regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.54641730
171negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54117622
172viral mRNA export from host cell nucleus (GO:0046784)2.54034995
173regulation of establishment of planar polarity (GO:0090175)2.53926374
174negative regulation of DNA-templated transcription, elongation (GO:0032785)2.53265624
175cell volume homeostasis (GO:0006884)2.53226249
176angiotensin maturation (GO:0002003)2.50171060
177skeletal muscle organ development (GO:0060538)2.49981380
178blood vessel endothelial cell migration (GO:0043534)2.48868367
179asymmetric protein localization (GO:0008105)2.48792203
180positive regulation of male gonad development (GO:2000020)2.48549406
181anatomical structure regression (GO:0060033)2.47038896
182mitotic G1/S transition checkpoint (GO:0044819)2.46422951
183camera-type eye development (GO:0043010)2.45622519
184surfactant homeostasis (GO:0043129)2.45136755
185glomerular visceral epithelial cell development (GO:0072015)17.4973540
186glomerular epithelial cell development (GO:0072310)16.3948182
187glomerular basement membrane development (GO:0032836)14.8247215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.10120285
2SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.90608967
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.48793146
4* ERG_21242973_ChIP-ChIP_JURKAT_Human3.47828608
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.99260100
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93719655
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93719655
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93719655
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.85019880
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.74478497
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.69160401
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.57666491
13POU5F1_16518401_ChIP-PET_MESCs_Mouse2.46448612
14LXR_22292898_ChIP-Seq_THP-1_Human2.38961692
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.38904467
16MYC_22102868_ChIP-Seq_BL_Human2.27923796
17P68_20966046_ChIP-Seq_HELA_Human2.27017677
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23727015
19TCF7_22412390_ChIP-Seq_EML_Mouse2.19609962
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18093856
21TCF3_18692474_ChIP-Seq_MESCs_Mouse2.17788058
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.17110761
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.14923378
24TCF3_18692474_ChIP-Seq_MEFs_Mouse2.12137309
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.08894149
26SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.06498015
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04850125
28* RUNX1_27514584_Chip-Seq_MCF-7_Human1.98902128
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.98340482
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98214650
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.95646483
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.95129347
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.92810094
34NANOG_21062744_ChIP-ChIP_HESCs_Human1.91490038
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.90867352
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85687180
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78857074
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.78552206
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74139715
40* KDM2B_26808549_Chip-Seq_K562_Human1.73922920
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.72267873
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70181933
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.68175211
44VDR_21846776_ChIP-Seq_THP-1_Human1.67998305
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.67971313
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.67378395
47DROSHA_22980978_ChIP-Seq_HELA_Human1.66395069
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.62783097
49NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.61877609
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61820891
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60185431
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59117428
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58297482
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.54641789
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52234119
56PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.52094793
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52005541
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47399477
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45887583
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43465817
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43458692
62BCOR_27268052_Chip-Seq_Bcells_Human1.42875372
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41874096
64KDM2B_26808549_Chip-Seq_DND41_Human1.41682747
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39557355
66RACK7_27058665_Chip-Seq_MCF-7_Human1.37417036
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37402929
68BCL6_27268052_Chip-Seq_Bcells_Human1.35840845
69SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.33076661
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32250996
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31281131
72MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.30979788
73TP53_23651856_ChIP-Seq_MEFs_Mouse1.29127901
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28601553
75* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28589669
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24811902
77TET1_21490601_ChIP-Seq_MESCs_Mouse1.23905121
78TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.23435572
79MAF_26560356_Chip-Seq_TH2_Human1.22817187
80TP53_22127205_ChIP-Seq_IMR90_Human1.22752236
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22739858
82* TET1_21451524_ChIP-Seq_MESCs_Mouse1.21882275
83PHF8_20622854_ChIP-Seq_HELA_Human1.21695209
84* TP63_22573176_ChIP-Seq_HFKS_Human1.21694492
85VDR_24763502_ChIP-Seq_THP-1_Human1.21234155
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21079946
87CTCF_26484167_Chip-Seq_Bcells_Mouse1.19450287
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18363010
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18139733
90NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18103653
91E2F1_20622854_ChIP-Seq_HELA_Human1.17886662
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17410646
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14888742
94* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13333058
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13055245
96POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12817354
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11738837
98CTCF_27219007_Chip-Seq_Bcells_Human1.11556386
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11086659
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.10756391
101SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10657273
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.09952741
103NANOG_16518401_ChIP-PET_MESCs_Mouse1.09411805
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09406765
105RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08868274
106FOXP1_21924763_ChIP-Seq_HESCs_Human1.07616835
107UTX_26944678_Chip-Seq_JUKART_Human1.07418181
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06965147
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06836693
110NCOR1_26117541_ChIP-Seq_K562_Human1.06114586
111SMC4_20622854_ChIP-Seq_HELA_Human1.05729962
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05252882
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05197329
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04918809
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04293842
116MAF_26560356_Chip-Seq_TH1_Human1.04162630
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03869362
118OCT4_19829295_ChIP-Seq_ESCs_Human1.03305622
119MYC_27129775_Chip-Seq_CORNEA_Mouse1.03261901
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.02907350
121EZH2_27294783_Chip-Seq_ESCs_Mouse1.02498800
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02060035
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01321338
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01305664
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01064739
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01002853
127SA1_27219007_Chip-Seq_Bcells_Human1.00381896
128ZNF263_19887448_ChIP-Seq_K562_Human1.00292761
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99849737
130STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99774076
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99468945
132P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99368375
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99142877
134KDM2B_26808549_Chip-Seq_JURKAT_Human0.98676957
135CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98544178
136CTCF_21964334_Chip-Seq_Bcells_Human0.97808362
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.97150300
138CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96935956
139SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.96804472
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.96436939
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.95460393
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94662598
143* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94027270
144RARB_24833708_ChIP-Seq_LIVER_Mouse0.94004895
145DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93431562
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.91462244
147TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91088292
148NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90837773
149CREB1_26743006_Chip-Seq_LNCaP_Human0.89698740
150TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89560574
151KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89084344
152OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88526896
153SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88398899
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86542200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.98799331
2MP0005623_abnormal_meninges_morphology4.11824508
3MP0004233_abnormal_muscle_weight3.80646125
4MP0008057_abnormal_DNA_replication3.66945735
5MP0003705_abnormal_hypodermis_morpholog3.62761371
6MP0003283_abnormal_digestive_organ3.50764406
7MP0001849_ear_inflammation3.32515771
8MP0002653_abnormal_ependyma_morphology3.27664334
9MP0005171_absent_coat_pigmentation3.09411386
10MP0010234_abnormal_vibrissa_follicle3.07491688
11MP0009278_abnormal_bone_marrow3.06347532
12MP0004381_abnormal_hair_follicle3.04239118
13MP0005058_abnormal_lysosome_morphology2.99360704
14MP0006072_abnormal_retinal_apoptosis2.83723964
15MP0000566_synostosis2.79243091
16MP0005409_darkened_coat_color2.67753760
17MP0004272_abnormal_basement_membrane2.63623195
18MP0004133_heterotaxia2.57928254
19MP0003942_abnormal_urinary_system2.52729379
20MP0002822_catalepsy2.48973937
21MP0008260_abnormal_autophagy2.34434579
22MP0002796_impaired_skin_barrier2.31515827
23MP0002009_preneoplasia2.17104147
24MP0004264_abnormal_extraembryonic_tissu2.07984406
25MP0000537_abnormal_urethra_morphology2.07237414
26MP0002282_abnormal_trachea_morphology2.03226982
27MP0002249_abnormal_larynx_morphology2.03052017
28MP0003890_abnormal_embryonic-extraembry2.00637801
29MP0000534_abnormal_ureter_morphology1.95284378
30MP0003119_abnormal_digestive_system1.93290702
31MP0000579_abnormal_nail_morphology1.93200128
32MP0001873_stomach_inflammation1.91037910
33MP0009384_cardiac_valve_regurgitation1.88873900
34MP0002098_abnormal_vibrissa_morphology1.88547780
35MP0002254_reproductive_system_inflammat1.86322980
36MP0004084_abnormal_cardiac_muscle1.85715268
37MP0003941_abnormal_skin_development1.84410309
38MP0004859_abnormal_synaptic_plasticity1.82273882
39MP0001324_abnormal_eye_pigmentation1.74712537
40MP0008995_early_reproductive_senescence1.72206812
41MP0005076_abnormal_cell_differentiation1.68938655
42MP0000462_abnormal_digestive_system1.67583113
43MP0001293_anophthalmia1.65496157
44MP0001348_abnormal_lacrimal_gland1.65218414
45MP0002089_abnormal_postnatal_growth/wei1.64063317
46MP0005501_abnormal_skin_physiology1.61578324
47MP0003878_abnormal_ear_physiology1.61046385
48MP0005377_hearing/vestibular/ear_phenot1.61046385
49MP0000003_abnormal_adipose_tissue1.58716218
50MP0005083_abnormal_biliary_tract1.57927065
51MP0004185_abnormal_adipocyte_glucose1.54360403
52MP0001661_extended_life_span1.53786119
53MP0000678_abnormal_parathyroid_gland1.53423011
54MP0001346_abnormal_lacrimal_gland1.51989915
55MP0002932_abnormal_joint_morphology1.49234471
56MP0003787_abnormal_imprinting1.48951770
57MP0004858_abnormal_nervous_system1.45559572
58MP0002933_joint_inflammation1.44209684
59MP0002084_abnormal_developmental_patter1.43831046
60MP0000383_abnormal_hair_follicle1.43119025
61MP0002135_abnormal_kidney_morphology1.40781505
62MP0009780_abnormal_chondrocyte_physiolo1.35794505
63MP0003123_paternal_imprinting1.33226414
64MP0003935_abnormal_craniofacial_develop1.31980134
65MP0000013_abnormal_adipose_tissue1.29448151
66MP0002085_abnormal_embryonic_tissue1.29383692
67MP0001879_abnormal_lymphatic_vessel1.28562925
68MP0000751_myopathy1.26760750
69MP0000681_abnormal_thyroid_gland1.25350583
70MP0003755_abnormal_palate_morphology1.24906765
71MP0002269_muscular_atrophy1.24748536
72MP0002116_abnormal_craniofacial_bone1.23822882
73MP0005375_adipose_tissue_phenotype1.22182898
74MP0003183_abnormal_peptide_metabolism1.21926039
75MP0010678_abnormal_skin_adnexa1.21745351
76MP0005666_abnormal_adipose_tissue1.21282782
77MP0002697_abnormal_eye_size1.18059964
78MP0003172_abnormal_lysosome_physiology1.17650778
79MP0004197_abnormal_fetal_growth/weight/1.16504053
80MP0003115_abnormal_respiratory_system1.16060867
81MP0001502_abnormal_circadian_rhythm1.15834977
82MP0000470_abnormal_stomach_morphology1.13190151
83MP0001697_abnormal_embryo_size1.10850581
84MP0005508_abnormal_skeleton_morphology1.10605208
85MP0000049_abnormal_middle_ear1.10199882
86MP0002086_abnormal_extraembryonic_tissu1.09583943
87MP0001340_abnormal_eyelid_morphology1.07533972
88MP0000377_abnormal_hair_follicle1.04933708
89MP0010368_abnormal_lymphatic_system1.04649149
90MP0001784_abnormal_fluid_regulation1.04549543
91MP0005248_abnormal_Harderian_gland1.04520277
92MP0001915_intracranial_hemorrhage1.03545390
93MP0003453_abnormal_keratinocyte_physiol1.02545850
94MP0002136_abnormal_kidney_physiology1.02110197
95MP0002111_abnormal_tail_morphology1.01430289
96MP0005253_abnormal_eye_physiology1.01020593
97MP0000762_abnormal_tongue_morphology1.00101093
98MP0010307_abnormal_tumor_latency0.99425185
99MP0003385_abnormal_body_wall0.99089489
100MP0004947_skin_inflammation0.97497556
101MP0003137_abnormal_impulse_conducting0.97167248
102MP0005195_abnormal_posterior_eye0.96371154
103MP0005332_abnormal_amino_acid0.96150650
104MP0001286_abnormal_eye_development0.95718312
105MP0005391_vision/eye_phenotype0.95553756
106MP0003136_yellow_coat_color0.94516294
107MP0002114_abnormal_axial_skeleton0.93044888
108MP0000639_abnormal_adrenal_gland0.91935960
109MP0001216_abnormal_epidermal_layer0.91541113
110MP0005397_hematopoietic_system_phenotyp0.89945896
111MP0001545_abnormal_hematopoietic_system0.89945896
112MP0009053_abnormal_anal_canal0.89648354
113MP0000778_abnormal_nervous_system0.88808731
114MP0009931_abnormal_skin_appearance0.88507573
115MP0003861_abnormal_nervous_system0.88072770
116MP0005670_abnormal_white_adipose0.87257737
117MP0005367_renal/urinary_system_phenotyp0.87059095
118MP0000516_abnormal_urinary_system0.87059095
119MP0003191_abnormal_cellular_cholesterol0.86572202
120MP0000467_abnormal_esophagus_morphology0.86531179
121MP0003828_pulmonary_edema0.85683444
122MP0003786_premature_aging0.85605484
123MP0003879_abnormal_hair_cell0.83122517
124MP0000163_abnormal_cartilage_morphology0.82524294
125MP0000627_abnormal_mammary_gland0.81927445
126MP0001664_abnormal_digestion0.81850566
127MP0003634_abnormal_glial_cell0.81705391
128MP0000432_abnormal_head_morphology0.79707541
129MP0003635_abnormal_synaptic_transmissio0.79311640
130MP0003943_abnormal_hepatobiliary_system0.78872303
131MP0001765_abnormal_ion_homeostasis0.78741185
132MP0002092_abnormal_eye_morphology0.77613873
133MP0009672_abnormal_birth_weight0.76424450
134MP0010771_integument_phenotype0.76355371
135MP0002925_abnormal_cardiovascular_devel0.74206087
136MP0008932_abnormal_embryonic_tissue0.73674168
137MP0003938_abnormal_ear_development0.73434966
138MP0003567_abnormal_fetal_cardiomyocyte0.72057591
139MP0005075_abnormal_melanosome_morpholog0.71997147
140MP0002060_abnormal_skin_morphology0.71791787
141MP0004036_abnormal_muscle_relaxation0.71282149
142MP0001672_abnormal_embryogenesis/_devel0.71269734
143MP0005380_embryogenesis_phenotype0.71269734
144MP0003937_abnormal_limbs/digits/tail_de0.70756770
145MP0006138_congestive_heart_failure0.70460347
146MP0002396_abnormal_hematopoietic_system0.70149248
147MP0005451_abnormal_body_composition0.70048479
148MP0001188_hyperpigmentation0.70030514
149MP0005167_abnormal_blood-brain_barrier0.69970775
150MP0009643_abnormal_urine_homeostasis0.69545141
151MP0000371_diluted_coat_color0.69530847
152MP0008058_abnormal_DNA_repair0.68675578
153MP0002132_abnormal_respiratory_system0.68640758
154MP0002081_perinatal_lethality0.68628163
155MP0000955_abnormal_spinal_cord0.68501288
156MP0003566_abnormal_cell_adhesion0.68034314
157MP0003866_abnormal_defecation0.66149319
158MP0000026_abnormal_inner_ear0.66094254
159MP0005174_abnormal_tail_pigmentation0.66074480
160MP0010352_gastrointestinal_tract_polyps0.66011044
161MP0002063_abnormal_learning/memory/cond0.65774780
162MP0010630_abnormal_cardiac_muscle0.65699689
163MP0000477_abnormal_intestine_morphology0.65176986
164MP0000733_abnormal_muscle_development0.64003402
165MP0001614_abnormal_blood_vessel0.63877535
166MP0001731_abnormal_postnatal_growth0.61653270
167MP0000367_abnormal_coat/_hair0.61101545
168MP0005423_abnormal_somatic_nervous0.61057427
169MP0000858_altered_metastatic_potential0.59507267
170MP0001881_abnormal_mammary_gland0.58045488
171MP0002075_abnormal_coat/hair_pigmentati0.57770912
172MP0008874_decreased_physiological_sensi0.57190001
173MP0002970_abnormal_white_adipose0.57036392

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)9.66938927
2Focal segmental glomerulosclerosis (HP:0000097)7.99884719
3Abnormal albumin level (HP:0012116)7.11105567
4Hypoalbuminemia (HP:0003073)7.11105567
5Glomerulosclerosis (HP:0000096)6.05476713
6Concave nail (HP:0001598)5.31931816
7J-shaped sella turcica (HP:0002680)5.00816018
8Stage 5 chronic kidney disease (HP:0003774)4.95289040
9Obstructive sleep apnea (HP:0002870)4.89679926
10Nephritis (HP:0000123)4.64847210
11Coronal craniosynostosis (HP:0004440)4.50223525
12Broad face (HP:0000283)4.38912589
13Cervical subluxation (HP:0003308)4.19727822
14Turricephaly (HP:0000262)4.16966214
15Tubular atrophy (HP:0000092)4.04140794
16Rib fusion (HP:0000902)3.74755714
17Glomerulonephritis (HP:0000099)3.71811578
18Thin bony cortex (HP:0002753)3.71307195
19Nephrotic syndrome (HP:0000100)3.68306566
20Hyperacusis (HP:0010780)3.67376822
21Aplasia of the musculature (HP:0100854)3.64624515
22Annular pancreas (HP:0001734)3.64620408
23Flat acetabular roof (HP:0003180)3.63161532
24Bell-shaped thorax (HP:0001591)3.56201881
25Intestinal atresia (HP:0011100)3.49719758
26Stridor (HP:0010307)3.41058706
27Nuclear cataract (HP:0100018)3.31247946
28Neonatal respiratory distress (HP:0002643)3.29529754
29Hypoplastic ischia (HP:0003175)3.27065959
30Choanal stenosis (HP:0000452)3.23133063
31Corneal erosion (HP:0200020)3.22418042
32Flattened epiphyses (HP:0003071)3.07736478
33Rectal fistula (HP:0100590)3.04729324
34Rectovaginal fistula (HP:0000143)3.04729324
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.02297255
36Facial hemangioma (HP:0000329)2.95508333
37Flat capital femoral epiphysis (HP:0003370)2.95207534
38Abnormal hemoglobin (HP:0011902)2.90908276
39Ulnar bowing (HP:0003031)2.90769123
40Metaphyseal cupping (HP:0003021)2.88343368
41Pustule (HP:0200039)2.88110501
42Distal upper limb amyotrophy (HP:0007149)2.87279432
43Upper limb amyotrophy (HP:0009129)2.87279432
44Atelectasis (HP:0100750)2.87177252
45Deformed sella turcica (HP:0002681)2.82127234
46Hypoproteinemia (HP:0003075)2.80438053
47Intestinal fistula (HP:0100819)2.75371616
48Increased IgM level (HP:0003496)2.73450250
49Vaginal fistula (HP:0004320)2.72064743
50Abnormality of the ischium (HP:0003174)2.70212096
51Male infertility (HP:0003251)2.64322718
52Rapidly progressive (HP:0003678)2.64141377
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.62503982
54Absent epiphyses (HP:0010577)2.58824592
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.58824592
56Joint stiffness (HP:0001387)2.56479105
57Muscle fibrillation (HP:0010546)2.55133850
58Abnormal vertebral ossification (HP:0100569)2.51930629
59Tongue fasciculations (HP:0001308)2.51844319
60Proteinuria (HP:0000093)2.50325588
61Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.50207920
62Nonprogressive disorder (HP:0003680)2.49303544
63Alopecia of scalp (HP:0002293)2.48169868
64Cerebral aneurysm (HP:0004944)2.47079394
65Urinary glycosaminoglycan excretion (HP:0003541)2.45060049
66Mucopolysacchariduria (HP:0008155)2.45060049
67Anteriorly placed anus (HP:0001545)2.43809575
68Ependymoma (HP:0002888)2.40492207
69Pterygium (HP:0001059)2.40074281
70Short humerus (HP:0005792)2.37684294
71Alacrima (HP:0000522)2.37406603
72Vitreoretinal degeneration (HP:0000655)2.36278852
73Hematuria (HP:0000790)2.35899292
74Bronchomalacia (HP:0002780)2.33757605
75Abnormality of the thoracic spine (HP:0100711)2.33658811
76Easy fatigability (HP:0003388)2.33579338
77Lower limb asymmetry (HP:0100559)2.33253389
78Broad distal phalanx of finger (HP:0009836)2.31235615
79Hypochromic microcytic anemia (HP:0004840)2.31082970
80Shawl scrotum (HP:0000049)2.30167587
81Distal lower limb muscle weakness (HP:0009053)2.30048450
82Metaphyseal dysplasia (HP:0100255)2.29600912
83Diaphragmatic weakness (HP:0009113)2.23920733
84Spinal canal stenosis (HP:0003416)2.23791324
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22637789
86Abnormality of polysaccharide metabolism (HP:0011012)2.22637789
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22637789
88Absent radius (HP:0003974)2.21936428
89Polycythemia (HP:0001901)2.21885432
90Germ cell neoplasia (HP:0100728)2.21715790
91Hyperthyroidism (HP:0000836)2.21292280
92Aplasia involving forearm bones (HP:0009822)2.20287726
93Absent forearm bone (HP:0003953)2.20287726
94Aplasia/hypoplasia of the humerus (HP:0006507)2.19376592
95Poikiloderma (HP:0001029)2.19276037
96Growth hormone excess (HP:0000845)2.18079940
97Distal lower limb amyotrophy (HP:0008944)2.16008196
98Vertebral hypoplasia (HP:0008417)2.15695378
99Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.15695378
100Pointed chin (HP:0000307)2.15164941
101Visceral angiomatosis (HP:0100761)2.14053944
102Biconcave vertebral bodies (HP:0004586)2.13778675
103Thoracic kyphosis (HP:0002942)2.13724664
104Abnormal tarsal ossification (HP:0008369)2.11263197
105Neoplasm of the heart (HP:0100544)2.10483108
106Gastrointestinal atresia (HP:0002589)2.10120574
107Abnormality of the femoral head (HP:0003368)2.10021899
108Nasal polyposis (HP:0100582)2.09474831
109Dysostosis multiplex (HP:0000943)2.08485787
110Hand muscle atrophy (HP:0009130)2.07060371
111Spinal cord compression (HP:0002176)2.06721297
112Lymphangioma (HP:0100764)2.04146954
113Pili torti (HP:0003777)2.02027573
114Thin ribs (HP:0000883)2.01813842
115Narrow nasal bridge (HP:0000446)2.01633183
116Exostoses (HP:0100777)2.01623189
117Polar cataract (HP:0010696)2.00413511
118Testicular atrophy (HP:0000029)2.00127569
119Large for gestational age (HP:0001520)1.99768175
120Hypoparathyroidism (HP:0000829)1.99683933
121Sparse lateral eyebrow (HP:0005338)1.99598754
122Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.99437750
123Aplasia/Hypoplasia involving the musculature (HP:0001460)1.99199495
124Hemangiomatosis (HP:0007461)1.98469327
125Congenital hip dislocation (HP:0001374)1.97622402
126Aqueductal stenosis (HP:0002410)1.97041736
127Ankle clonus (HP:0011448)1.95554705
128Premature skin wrinkling (HP:0100678)1.95541266
129Mitral regurgitation (HP:0001653)1.94519294
130Orthostatic hypotension (HP:0001278)1.93756492
131Seborrheic dermatitis (HP:0001051)1.92996805
132Abdominal distention (HP:0003270)1.92244500
133Neurodegeneration (HP:0002180)1.91640142
134Patellar aplasia (HP:0006443)1.91188790
135Spinal muscular atrophy (HP:0007269)1.88396841
136Asymmetry of the thorax (HP:0001555)1.86277151
137Abnormality of the nasal mucosa (HP:0000433)1.85998289
138Protuberant abdomen (HP:0001538)1.85597326
139Supranuclear gaze palsy (HP:0000605)1.84995075
140Aplasia/hypoplasia of the femur (HP:0005613)1.84626675
141Increased CSF protein (HP:0002922)1.84530590
142Clumsiness (HP:0002312)1.84140250
143Abnormality of the aortic arch (HP:0012303)1.83854143
144Split hand (HP:0001171)1.83707096
145Tubulointerstitial fibrosis (HP:0005576)1.82917828
146Sleep apnea (HP:0010535)1.82628680
147Volvulus (HP:0002580)1.82163227
148Flared metaphyses (HP:0003015)1.81864000
149Anomalous pulmonary venous return (HP:0010772)1.81235512
150Abnormality of the sella turcica (HP:0002679)1.80338740
151Down-sloping shoulders (HP:0200021)1.80277350
152Abnormality of the labia minora (HP:0012880)1.79850340
153Precocious puberty (HP:0000826)1.79533023
154Long palpebral fissure (HP:0000637)1.79227332
155Congenital glaucoma (HP:0001087)1.79157581
156Hip contracture (HP:0003273)1.78872461
157Hemivertebrae (HP:0002937)1.78728103
158Short femoral neck (HP:0100864)1.77535949
159Colitis (HP:0002583)1.77235736
160Difficulty climbing stairs (HP:0003551)1.76716132
161Abnormal respiratory epithelium morphology (HP:0012253)1.75672842
162Abnormal respiratory motile cilium morphology (HP:0005938)1.75672842
163Hypoplasia of the odontoid process (HP:0003311)1.75575671
164Aplasia/Hypoplasia of the patella (HP:0006498)1.75028533
165Abnormality of the fingertips (HP:0001211)1.74863127
166Hamartoma (HP:0010566)1.74020639
167Preaxial foot polydactyly (HP:0001841)1.73257145
168Patellar dislocation (HP:0002999)1.72147948
169Abnormality of the upper arm (HP:0001454)1.71807576
170Anophthalmia (HP:0000528)1.70626876
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70214841
172Truncus arteriosus (HP:0001660)1.70149755
173Broad alveolar ridges (HP:0000187)1.69151638
174Decreased lacrimation (HP:0000633)1.68584194
175Bowed forearm bones (HP:0003956)1.68010824
176Bowing of the arm (HP:0006488)1.68010824
177Short chin (HP:0000331)1.67532157
178Delayed epiphyseal ossification (HP:0002663)1.67401613
179Abnormality of the epiphysis of the femoral head (HP:0010574)1.66287416
180Macroorchidism (HP:0000053)1.65259159
181Septate vagina (HP:0001153)1.63593180
182Abnormality of femoral epiphyses (HP:0006499)1.63028941
183Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.63028941
184Epiphyseal dysplasia (HP:0002656)1.62916227
185Urethral obstruction (HP:0000796)1.62490764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.91775035
2MAPK155.19652637
3DDR24.40303177
4MAP3K63.52417234
5PKN23.44300422
6EPHB23.33533694
7TYRO33.13327384
8PINK12.75394452
9MST1R2.74301479
10MAP3K112.67240515
11PDGFRA2.59259535
12SMG12.42756426
13MATK2.39023144
14FGR2.33545429
15TNK22.29533440
16BMX2.23695927
17UHMK12.18997259
18DAPK12.08473896
19PRKD22.02970462
20WNK41.94274966
21PAK41.91413681
22FGFR41.91384440
23DYRK1B1.90277247
24EEF2K1.80789000
25AKT31.78895492
26ERN11.78091606
27NME21.77253763
28TESK11.75925437
29CSK1.66445037
30YES11.63090817
31PTK61.53642094
32SIK31.52888705
33MAP2K61.49406837
34CAMKK11.47565552
35MUSK1.44145724
36LATS21.43519876
37OXSR11.40484017
38SIK21.40297252
39NTRK11.36335906
40NME11.28130353
41MAPKAPK31.27006320
42PIM21.22901203
43GSK3A1.20793628
44PHKG11.19412058
45PHKG21.19412058
46RPS6KA21.17100789
47RPS6KB21.16753259
48TRPM71.14310408
49CDK71.11961273
50PRKCI1.10899596
51CAMK2B1.09616425
52MET1.09301410
53STK391.04444470
54CDC42BPA1.02521026
55NTRK31.02248460
56MAP3K130.99792425
57TBK10.96664540
58MAP3K70.96033395
59MAP2K20.95271123
60MAP3K100.94942578
61NTRK20.94398387
62IRAK30.89428667
63RPS6KL10.89342900
64RPS6KC10.89342900
65GRK60.87086664
66LMTK20.85798699
67PRPF4B0.85073262
68CDK60.84531617
69KSR10.83430744
70MTOR0.82219080
71CHEK20.81034698
72NEK60.79203346
73MAP4K10.78247150
74RPS6KA60.74692366
75TRIB30.73797302
76RET0.73484726
77LATS10.72205028
78SIK10.70503968
79HIPK20.70380418
80TAOK10.68846146
81PIM10.68497484
82ERBB30.67522563
83MAPK110.66861363
84MAP2K30.66373207
85FGFR20.65514760
86CHUK0.62934874
87PRKAA10.62296839
88PRKD30.59917884
89MYLK0.59400360
90PDGFRB0.56500491
91LRRK20.55256273
92TAOK20.54405127
93TGFBR20.53411840
94TIE10.53105298
95CDK180.52568078
96STK38L0.52473025
97MAPK80.51895248
98PDPK10.51026766
99SCYL20.50775073
100IRAK20.49186328
101EGFR0.49103102
102PAK20.48980766
103ZAP700.45500686
104PRKCH0.45288851
105CDK150.45232312
106RPS6KA10.45059112
107EPHA40.44977376
108PTK20.43796004
109PRKD10.43079269
110CDK11A0.42915424
111STK380.42308941
112ILK0.40852955
113MAP3K10.39410533
114PLK10.37181674
115MAPKAPK20.36769812
116RIPK10.36596816
117MAP3K90.35980390
118MAPK90.34622126
119FGFR10.33941063
120MAPK70.33866513
121BTK0.33685444
122CAMK2G0.33618285
123TESK20.32357489
124MAPK10.32080068
125PRKCZ0.31909060
126CDK140.31412291
127MAPK120.31174027
128NEK10.30078681
129DYRK30.29210360
130CDK120.29176002
131EPHB10.28625341
132BCR0.28424483
133DAPK20.28373949
134SGK10.28029704
135MAPK40.27462669
136CDK20.27241850
137MAP3K30.26937475
138PAK60.26905165
139EPHA20.26772284
140MAPK100.26020240
141PDK10.25601386
142INSR0.24895071
143IKBKE0.24088126
144GSK3B0.22842666
145ERBB20.22757761
146PDK20.22180056
147PDK40.21325153
148PDK30.21325153
149STK30.20478220
150MARK20.20099112
151MAPK30.20080426
152CAMK2A0.19542263
153PRKACG0.19362952
154CDK190.19169974
155RPS6KB10.18870964
156KDR0.18597240
157RPS6KA30.18368830

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.48793717
2Other glycan degradation_Homo sapiens_hsa005113.40555797
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.35169691
4Base excision repair_Homo sapiens_hsa034102.99596536
5Hippo signaling pathway_Homo sapiens_hsa043902.72885506
6Mismatch repair_Homo sapiens_hsa034302.53192229
7Hedgehog signaling pathway_Homo sapiens_hsa043402.50093594
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.37211870
9ECM-receptor interaction_Homo sapiens_hsa045122.26965185
10Notch signaling pathway_Homo sapiens_hsa043302.26634118
11mTOR signaling pathway_Homo sapiens_hsa041502.23284134
12Renin-angiotensin system_Homo sapiens_hsa046142.20108080
13Small cell lung cancer_Homo sapiens_hsa052222.13852267
14Bladder cancer_Homo sapiens_hsa052192.12631473
15Adherens junction_Homo sapiens_hsa045202.09180263
16Axon guidance_Homo sapiens_hsa043602.01797966
17Acute myeloid leukemia_Homo sapiens_hsa052212.01598571
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.96920352
19Circadian rhythm_Homo sapiens_hsa047101.96768745
20Basal cell carcinoma_Homo sapiens_hsa052171.84566358
21Focal adhesion_Homo sapiens_hsa045101.75401542
22Non-small cell lung cancer_Homo sapiens_hsa052231.63511541
23Wnt signaling pathway_Homo sapiens_hsa043101.59664853
24Phospholipase D signaling pathway_Homo sapiens_hsa040721.55243964
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53026854
26VEGF signaling pathway_Homo sapiens_hsa043701.47271810
27DNA replication_Homo sapiens_hsa030301.42631126
28Lysine degradation_Homo sapiens_hsa003101.40849054
29ABC transporters_Homo sapiens_hsa020101.39265841
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39078453
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35281579
32N-Glycan biosynthesis_Homo sapiens_hsa005101.34789471
33GnRH signaling pathway_Homo sapiens_hsa049121.33867054
34Tight junction_Homo sapiens_hsa045301.33085485
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33005906
36Prolactin signaling pathway_Homo sapiens_hsa049171.31934524
37mRNA surveillance pathway_Homo sapiens_hsa030151.29103919
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28748987
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28071967
40TGF-beta signaling pathway_Homo sapiens_hsa043501.27094171
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24868547
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.24738514
43Inositol phosphate metabolism_Homo sapiens_hsa005621.24292728
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.23589335
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.23498399
46Dorso-ventral axis formation_Homo sapiens_hsa043201.22693628
47Protein digestion and absorption_Homo sapiens_hsa049741.21923483
48Phototransduction_Homo sapiens_hsa047441.21766523
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19420263
50Arginine and proline metabolism_Homo sapiens_hsa003301.19261389
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18128828
52Proteoglycans in cancer_Homo sapiens_hsa052051.16242748
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14394233
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13893155
55Amoebiasis_Homo sapiens_hsa051461.11610932
56Fatty acid metabolism_Homo sapiens_hsa012121.07829727
57Hepatitis C_Homo sapiens_hsa051601.06900096
58Gap junction_Homo sapiens_hsa045401.03229249
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03119350
60MicroRNAs in cancer_Homo sapiens_hsa052061.01562880
61ErbB signaling pathway_Homo sapiens_hsa040121.01326554
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99895482
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99091053
64Cocaine addiction_Homo sapiens_hsa050300.96893122
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95089832
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.91743838
67Oocyte meiosis_Homo sapiens_hsa041140.90050211
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90014297
69Sulfur relay system_Homo sapiens_hsa041220.89858014
70Shigellosis_Homo sapiens_hsa051310.89513921
71Insulin secretion_Homo sapiens_hsa049110.88848606
72Thyroid cancer_Homo sapiens_hsa052160.88520966
73Synaptic vesicle cycle_Homo sapiens_hsa047210.87019742
74Insulin resistance_Homo sapiens_hsa049310.86572352
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.81573576
76Phenylalanine metabolism_Homo sapiens_hsa003600.80474977
77Amphetamine addiction_Homo sapiens_hsa050310.80308669
78Pathways in cancer_Homo sapiens_hsa052000.79457605
79Chronic myeloid leukemia_Homo sapiens_hsa052200.78823897
80Pentose phosphate pathway_Homo sapiens_hsa000300.78632323
81B cell receptor signaling pathway_Homo sapiens_hsa046620.77994555
82Long-term potentiation_Homo sapiens_hsa047200.77942345
83Pancreatic cancer_Homo sapiens_hsa052120.76221792
84Colorectal cancer_Homo sapiens_hsa052100.75841552
85Rap1 signaling pathway_Homo sapiens_hsa040150.75301118
86Lysosome_Homo sapiens_hsa041420.73193819
87Choline metabolism in cancer_Homo sapiens_hsa052310.70852768
88Biosynthesis of amino acids_Homo sapiens_hsa012300.70833784
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.70033083
90Viral myocarditis_Homo sapiens_hsa054160.69003180
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67926059
92p53 signaling pathway_Homo sapiens_hsa041150.67906852
93Spliceosome_Homo sapiens_hsa030400.66883043
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66268249
95Endometrial cancer_Homo sapiens_hsa052130.64758831
96Cholinergic synapse_Homo sapiens_hsa047250.63703920
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63434529
98Nucleotide excision repair_Homo sapiens_hsa034200.62726724
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.62403445
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60301053
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59935172
102T cell receptor signaling pathway_Homo sapiens_hsa046600.59208871
103cAMP signaling pathway_Homo sapiens_hsa040240.58921352
104Circadian entrainment_Homo sapiens_hsa047130.58850651
105Endocytosis_Homo sapiens_hsa041440.58753833
106Dopaminergic synapse_Homo sapiens_hsa047280.58437774
107Oxytocin signaling pathway_Homo sapiens_hsa049210.58176999
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57691727
109Cell cycle_Homo sapiens_hsa041100.57132382
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56901259
111Melanogenesis_Homo sapiens_hsa049160.56755615
112Salivary secretion_Homo sapiens_hsa049700.56042731
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55485494
114Estrogen signaling pathway_Homo sapiens_hsa049150.54668402
115Dilated cardiomyopathy_Homo sapiens_hsa054140.53682041
116Insulin signaling pathway_Homo sapiens_hsa049100.53396055
117Vibrio cholerae infection_Homo sapiens_hsa051100.52272966
118Glioma_Homo sapiens_hsa052140.51980912
119Histidine metabolism_Homo sapiens_hsa003400.51920316
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51781595
121Renal cell carcinoma_Homo sapiens_hsa052110.51101591
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51067449
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50476084
124Sphingolipid metabolism_Homo sapiens_hsa006000.50331108
125RNA transport_Homo sapiens_hsa030130.48976576
126TNF signaling pathway_Homo sapiens_hsa046680.48115859
127Thyroid hormone synthesis_Homo sapiens_hsa049180.48068600
128Hepatitis B_Homo sapiens_hsa051610.47089302
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.46932366
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46717033
131MAPK signaling pathway_Homo sapiens_hsa040100.46424534
132Prostate cancer_Homo sapiens_hsa052150.46361386
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45791744
134Ras signaling pathway_Homo sapiens_hsa040140.45712167
135AMPK signaling pathway_Homo sapiens_hsa041520.45676760
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.45035576
137Fructose and mannose metabolism_Homo sapiens_hsa000510.44912620
138Ovarian steroidogenesis_Homo sapiens_hsa049130.44715057
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44116895
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42751068
141Cyanoamino acid metabolism_Homo sapiens_hsa004600.41912557
142Mineral absorption_Homo sapiens_hsa049780.40742734
143Fanconi anemia pathway_Homo sapiens_hsa034600.38392063
144Folate biosynthesis_Homo sapiens_hsa007900.35233102
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29978464
146Gastric acid secretion_Homo sapiens_hsa049710.28553835
147Olfactory transduction_Homo sapiens_hsa047400.27356357
148Melanoma_Homo sapiens_hsa052180.26590406
149GABAergic synapse_Homo sapiens_hsa047270.25740361
150Glucagon signaling pathway_Homo sapiens_hsa049220.24776007

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