RIBC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.84202040
2regulation of cilium movement (GO:0003352)8.57972910
3left/right pattern formation (GO:0060972)8.55652640
4ventricular system development (GO:0021591)7.14830920
5intraciliary transport (GO:0042073)6.88147191
6left/right axis specification (GO:0070986)6.36644250
7cilium organization (GO:0044782)6.24804945
8microtubule bundle formation (GO:0001578)6.08633678
9cilium assembly (GO:0042384)6.08183230
10primary alcohol catabolic process (GO:0034310)5.54639732
11sperm capacitation (GO:0048240)5.54013489
12regulation of microtubule-based movement (GO:0060632)5.20199870
13mitotic metaphase plate congression (GO:0007080)5.01999387
14protein localization to cilium (GO:0061512)4.97715103
15microtubule-based movement (GO:0007018)4.89245817
16sperm motility (GO:0030317)4.86356320
17vitamin transmembrane transport (GO:0035461)4.85463066
18cellular component assembly involved in morphogenesis (GO:0010927)4.74778195
19ethanol metabolic process (GO:0006067)4.74020896
20centriole replication (GO:0007099)4.71653183
21cilium morphogenesis (GO:0060271)4.56403246
22negative regulation of inclusion body assembly (GO:0090084)4.47905958
23CENP-A containing nucleosome assembly (GO:0034080)4.47315898
24diterpenoid biosynthetic process (GO:0016102)4.45897582
25chromatin remodeling at centromere (GO:0031055)4.40770590
26metaphase plate congression (GO:0051310)4.31793915
27histone exchange (GO:0043486)4.27827330
28cell projection assembly (GO:0030031)4.21576425
29synaptonemal complex assembly (GO:0007130)4.19559989
30glomerular epithelial cell development (GO:0072310)4.16656012
31pyrimidine-containing compound transmembrane transport (GO:0072531)4.08924218
32one-carbon compound transport (GO:0019755)4.08338045
33DNA replication checkpoint (GO:0000076)4.08018163
34negative regulation of T cell differentiation in thymus (GO:0033085)4.03888338
35DNA replication-independent nucleosome assembly (GO:0006336)3.99347317
36DNA replication-independent nucleosome organization (GO:0034724)3.99347317
37protein localization to kinetochore (GO:0034501)3.98940408
38nucleoside diphosphate phosphorylation (GO:0006165)3.98545592
39establishment of tissue polarity (GO:0007164)3.97052193
40establishment of planar polarity (GO:0001736)3.97052193
41mitotic chromosome condensation (GO:0007076)3.96394284
42protein localization to chromosome, centromeric region (GO:0071459)3.96312130
43ribosomal small subunit assembly (GO:0000028)3.93020580
44microtubule polymerization or depolymerization (GO:0031109)3.89112468
45lung epithelium development (GO:0060428)3.89031645
46synaptonemal complex organization (GO:0070193)3.87427469
47establishment of apical/basal cell polarity (GO:0035089)3.82955267
48establishment of chromosome localization (GO:0051303)3.79169357
49maturation of SSU-rRNA (GO:0030490)3.79074799
50ribosome assembly (GO:0042255)3.78973967
51regulation of interleukin-5 production (GO:0032674)3.74942823
52attachment of spindle microtubules to kinetochore (GO:0008608)3.72834759
53binding of sperm to zona pellucida (GO:0007339)3.72684031
54sperm-egg recognition (GO:0035036)3.69200257
55mitotic nuclear envelope disassembly (GO:0007077)3.65669706
56response to pheromone (GO:0019236)3.64080873
57tolerance induction (GO:0002507)3.63625259
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63047985
59male meiosis (GO:0007140)3.62714854
60negative regulation of B cell mediated immunity (GO:0002713)3.62259457
61negative regulation of immunoglobulin mediated immune response (GO:0002890)3.62259457
62kinetochore organization (GO:0051383)3.62148552
63mitotic sister chromatid segregation (GO:0000070)3.61578732
64nucleobase biosynthetic process (GO:0046112)3.61520595
65fusion of sperm to egg plasma membrane (GO:0007342)3.59518910
66purine nucleobase biosynthetic process (GO:0009113)3.58121480
67lateral sprouting from an epithelium (GO:0060601)3.56346451
68DNA replication-dependent nucleosome assembly (GO:0006335)3.56214265
69DNA replication-dependent nucleosome organization (GO:0034723)3.56214265
70response to xenobiotic stimulus (GO:0009410)3.55092419
71regulation of spindle organization (GO:0090224)3.52827211
72piRNA metabolic process (GO:0034587)3.52578176
73meiosis I (GO:0007127)3.51345318
74ethanol oxidation (GO:0006069)3.51112766
75regulation of interleukin-13 production (GO:0032656)3.47147217
76DNA replication initiation (GO:0006270)3.47045521
77kinetochore assembly (GO:0051382)3.46485933
78regulation of chromosome segregation (GO:0051983)3.45247458
79positive regulation of chromosome segregation (GO:0051984)3.44701498
80microtubule depolymerization (GO:0007019)3.43480638
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42493868
82lateral ventricle development (GO:0021670)3.41956979
83membrane disassembly (GO:0030397)3.41385006
84nuclear envelope disassembly (GO:0051081)3.41385006
85smoothened signaling pathway (GO:0007224)3.41113807
86formation of translation preinitiation complex (GO:0001731)3.38938056
87meiotic chromosome segregation (GO:0045132)3.37631046
88ribosome biogenesis (GO:0042254)3.37325189
89apical protein localization (GO:0045176)3.35642634
90spliceosomal snRNP assembly (GO:0000387)3.33298027
91negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.33230421
92negative regulation of DNA-templated transcription, elongation (GO:0032785)3.33230421
93spermatid development (GO:0007286)3.33142236
94chromosome condensation (GO:0030261)3.31948708
95establishment or maintenance of monopolar cell polarity (GO:0061339)3.28855258
96establishment of monopolar cell polarity (GO:0061162)3.28855258
97determination of left/right symmetry (GO:0007368)3.28103848
98cell-cell recognition (GO:0009988)3.26979133
99male meiosis I (GO:0007141)3.26441919
100negative regulation of humoral immune response (GO:0002921)3.24786763
101DNA strand elongation involved in DNA replication (GO:0006271)3.24622694
102chromosome organization involved in meiosis (GO:0070192)3.23854690
103regulation of inclusion body assembly (GO:0090083)3.22328655
104axonemal dynein complex assembly (GO:0070286)3.22220801
105protein localization to chromosome (GO:0034502)3.21029307
106retinoic acid metabolic process (GO:0042573)3.18690106
107spindle checkpoint (GO:0031577)3.18019773
108meiotic nuclear division (GO:0007126)3.17991356
109multicellular organism reproduction (GO:0032504)3.16778058
110regulation of double-strand break repair via homologous recombination (GO:0010569)3.15721902
111determination of bilateral symmetry (GO:0009855)3.15437148
112acrosome reaction (GO:0007340)3.15097503
113negative regulation of chromosome segregation (GO:0051985)3.14084379
114ATP-dependent chromatin remodeling (GO:0043044)3.13410331
115sister chromatid segregation (GO:0000819)3.12957641
116proteasome assembly (GO:0043248)3.12873951
117asymmetric protein localization (GO:0008105)3.12497896
118DNA strand elongation (GO:0022616)3.11988692
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10305144
120negative regulation of sister chromatid segregation (GO:0033046)3.10305144
121negative regulation of mitotic sister chromatid separation (GO:2000816)3.10305144
122negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10305144
123phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.09448598
124specification of symmetry (GO:0009799)3.09340337
125DNA packaging (GO:0006323)3.08596204
126nuclear pore organization (GO:0006999)3.08059093
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07987341
128meiotic cell cycle process (GO:1903046)3.06641038
129ribonucleoprotein complex biogenesis (GO:0022613)3.05901818
130glutathione derivative metabolic process (GO:1901685)3.05778156
131glutathione derivative biosynthetic process (GO:1901687)3.05778156
132chromatin assembly or disassembly (GO:0006333)3.05776151
133regulation of mitotic spindle organization (GO:0060236)3.04741014
134mitotic spindle checkpoint (GO:0071174)3.04438641
135telomere maintenance via recombination (GO:0000722)3.00482891
136regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00068561
137motile cilium assembly (GO:0044458)2.99744372
138DNA deamination (GO:0045006)2.99250141
139positive regulation of smoothened signaling pathway (GO:0045880)2.99231528
140spindle assembly checkpoint (GO:0071173)2.99018671
141cell wall macromolecule metabolic process (GO:0044036)2.98614217
142cell wall macromolecule catabolic process (GO:0016998)2.98614217
143regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98510181
144anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98445633
145chromosome segregation (GO:0007059)2.98319275
146DNA unwinding involved in DNA replication (GO:0006268)2.97767725
147folic acid-containing compound biosynthetic process (GO:0009396)2.97634382
148terpenoid biosynthetic process (GO:0016114)2.95346899
149telomere maintenance via semi-conservative replication (GO:0032201)2.95129651
150protein polyglutamylation (GO:0018095)2.95022336
151cytoplasmic microtubule organization (GO:0031122)2.94766518
152spliceosomal complex assembly (GO:0000245)2.94158282
153reciprocal DNA recombination (GO:0035825)2.94067637
154reciprocal meiotic recombination (GO:0007131)2.94067637
155regulation of centrosome cycle (GO:0046605)2.93194191
156mitotic spindle assembly checkpoint (GO:0007094)2.93187973
157regulation of RNA export from nucleus (GO:0046831)2.93078738
158mitotic recombination (GO:0006312)2.92552791
159dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.92467786
160folic acid metabolic process (GO:0046655)2.92007963
161mitotic sister chromatid cohesion (GO:0007064)2.91880597
162centriole assembly (GO:0098534)2.91686180
163cilium or flagellum-dependent cell motility (GO:0001539)2.91562295
164embryonic camera-type eye development (GO:0031076)2.90619755
165microtubule-based process (GO:0007017)2.90547055
166ribosomal large subunit biogenesis (GO:0042273)2.90268438
167retinol metabolic process (GO:0042572)2.83726989
168regulation of autophagic vacuole assembly (GO:2000785)2.82690566
169negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.78789384
170microtubule severing (GO:0051013)2.78631881
171negative regulation of oligodendrocyte differentiation (GO:0048715)2.73735099
172organelle assembly (GO:0070925)2.73027295
173primary alcohol metabolic process (GO:0034308)2.69415725
174regulation of germinal center formation (GO:0002634)2.67255983
175intra-S DNA damage checkpoint (GO:0031573)2.65747802
176protein refolding (GO:0042026)2.64467086
177single fertilization (GO:0007338)2.58521789
178positive regulation of tolerance induction (GO:0002645)2.56057163
179exogenous drug catabolic process (GO:0042738)2.54247604
180nonmotile primary cilium assembly (GO:0035058)2.49122278
181oligosaccharide biosynthetic process (GO:0009312)2.40813758
182regulation of vacuole organization (GO:0044088)2.38572303
183O-glycan processing (GO:0016266)2.36886036
184phosphatidylethanolamine biosynthetic process (GO:0006646)2.36834991
185axon ensheathment in central nervous system (GO:0032291)2.36721627
186central nervous system myelination (GO:0022010)2.36721627
187hydrogen peroxide biosynthetic process (GO:0050665)2.35477607
188reproduction (GO:0000003)2.32210363
189regulation of smoothened signaling pathway (GO:0008589)2.31867800
190cilium movement (GO:0003341)15.9953443
191epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.2652255
192epithelial cilium movement (GO:0003351)14.8721589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.63217341
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.10434947
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.73867673
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.40345198
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.06409356
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.73439711
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64923962
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35593913
9DROSHA_22980978_ChIP-Seq_HELA_Human3.10662574
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03708504
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96506724
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.94358855
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92943476
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.87802702
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80036208
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72356687
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.68269637
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.64002538
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.62337303
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61055433
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59318119
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56799358
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.47510899
24AR_21909140_ChIP-Seq_LNCAP_Human2.38824366
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34421373
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21527780
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19098820
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16705747
29* VDR_23849224_ChIP-Seq_CD4+_Human2.15896772
30XRN2_22483619_ChIP-Seq_HELA_Human2.14873190
31ESR1_20079471_ChIP-ChIP_T-47D_Human2.11249205
32AHR_22903824_ChIP-Seq_MCF-7_Human2.09032789
33SMC4_20622854_ChIP-Seq_HELA_Human1.97603770
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96609237
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.96221436
36FOXP3_21729870_ChIP-Seq_TREG_Human1.92858414
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89482026
38DCP1A_22483619_ChIP-Seq_HELA_Human1.86325382
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.85999802
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85083830
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82893961
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79925930
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.79592533
44GABP_19822575_ChIP-Seq_HepG2_Human1.78694893
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.76618638
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75161820
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74231476
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70463093
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.69815707
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66991290
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66944663
52STAT1_20625510_ChIP-Seq_HELA_Human1.66515631
53VDR_22108803_ChIP-Seq_LS180_Human1.64750137
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.60525736
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.59015793
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.58980801
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56943904
58CTCF_27219007_Chip-Seq_Bcells_Human1.55829151
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.54677156
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54599484
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53477924
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.52803653
63TTF2_22483619_ChIP-Seq_HELA_Human1.52196726
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.49916198
65TP63_22573176_ChIP-Seq_HFKS_Human1.49358339
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49316975
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.48342773
68PHF8_20622854_ChIP-Seq_HELA_Human1.47756203
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47127913
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47007681
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46412142
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43724040
73CIITA_25753668_ChIP-Seq_RAJI_Human1.43550523
74CTCF_20526341_ChIP-Seq_ESCs_Human1.43191727
75P68_20966046_ChIP-Seq_HELA_Human1.41218076
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41105206
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40693838
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39852042
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39558700
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38264608
81KDM5A_27292631_Chip-Seq_BREAST_Human1.38185154
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37739607
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37427438
84FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36462911
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36306876
86ERA_21632823_ChIP-Seq_H3396_Human1.36001240
87KLF5_25053715_ChIP-Seq_YYC3_Human1.34893810
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34664711
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34152291
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33671614
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31109921
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29621130
93HNFA_21074721_ChIP-Seq_CACO-2_Human1.29161767
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28732347
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28304723
96PHF8_20622853_ChIP-Seq_HELA_Human1.28138385
97ZNF263_19887448_ChIP-Seq_K562_Human1.28035915
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27621981
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.27502850
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27369810
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26522251
102RAD21_21589869_ChIP-Seq_MESCs_Mouse1.26331643
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25988951
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25408983
105TP63_23658742_ChIP-Seq_EP156T_Human1.24608604
106ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23850709
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22605713
108EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.21175949
109ETV1_20927104_ChIP-Seq_GIST48_Human1.20219453
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19763945
111CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19626867
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19485940
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18708882
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18363389
115SMRT_27268052_Chip-Seq_Bcells_Human1.17191082
116RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16842373
117PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16751771
118P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15314066
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14968197
120EGR1_19374776_ChIP-ChIP_THP-1_Human1.14783963
121E2F1_20622854_ChIP-Seq_HELA_Human1.14238530
122AR_21572438_ChIP-Seq_LNCaP_Human1.13527964
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13341241
124P300_27268052_Chip-Seq_Bcells_Human1.13094412
125ELK1_19687146_ChIP-ChIP_HELA_Human1.13057974
126TP53_18474530_ChIP-ChIP_U2OS_Human1.12956270
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12392169
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11469750
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11075568
130KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10701275
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10285423
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10066448
133TBL1_22424771_ChIP-Seq_293T_Human1.09882824
134MYC_22102868_ChIP-Seq_BL_Human1.09842775
135EZH2_27294783_Chip-Seq_ESCs_Mouse1.09583653
136SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08808346
137BCOR_27268052_Chip-Seq_Bcells_Human1.08503770
138CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08023872
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07883203
140WDR5_24793694_ChIP-Seq_LNCAP_Human1.07637647
141FOXA1_25552417_ChIP-Seq_VCAP_Human1.07322784
142E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07065478
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06270076
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06055164
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05909796
146MYC_19829295_ChIP-Seq_ESCs_Human1.04750246
147NFYA_21822215_ChIP-Seq_K562_Human1.04716846
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03414805
149NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03396242
150KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02751437
151BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02377951
152PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02032969
153CDX2_20551321_ChIP-Seq_CACO-2_Human1.01851374
154GATA3_24758297_ChIP-Seq_MCF-7_Human1.01422639
155ERG_20517297_ChIP-Seq_VCAP_Human1.00916789
156TP63_19390658_ChIP-ChIP_HaCaT_Human1.00770459
157RBPJ_21746931_ChIP-Seq_IB4_Human1.00337646
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00158351
159SOX2_21211035_ChIP-Seq_LN229_Human0.99934448
160GATA6_21074721_ChIP-Seq_CACO-2_Human0.99714559
161OCT4_20526341_ChIP-Seq_ESCs_Human0.99642906
162NFYB_21822215_ChIP-Seq_K562_Human0.99287820
163SA1_27219007_Chip-Seq_ERYTHROID_Human0.99180578
164CBP_21632823_ChIP-Seq_H3396_Human0.99069567
165GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98951122
166BCL6_27268052_Chip-Seq_Bcells_Human0.98145098
167TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97693483
168NANOG_21062744_ChIP-ChIP_HESCs_Human0.97477185
169AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97474514
170P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95602619
171CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95578125
172CEBPB_22108803_ChIP-Seq_LS180_Human0.95427826
173SOX2_22085726_ChIP-Seq_NPCs_Mouse0.94971609
174ER_23166858_ChIP-Seq_MCF-7_Human0.94941096
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.94556912
176FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94154650
177FOXA1_25329375_ChIP-Seq_VCAP_Human0.94154650
178EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93448520
179TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92337102
180ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90162759
181CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89567698
182RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87207156
183ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86450896
184SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85533324
185CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85115799
186MYC_18940864_ChIP-ChIP_HL60_Human0.83454113
187TFEB_21752829_ChIP-Seq_HELA_Human0.82529544
188TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.82506531
189SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81070871
190CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80056697
191NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79595177
192SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78974189
193POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.78512092
194RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78105750
195TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77881739
196KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76402274
197GATA1_26923725_Chip-Seq_HPCs_Mouse0.75642344
198NOTCH1_21737748_ChIP-Seq_TLL_Human0.73521217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.60223064
2MP0003136_yellow_coat_color5.17451437
3MP0008875_abnormal_xenobiotic_pharmacok4.76013309
4MP0010094_abnormal_chromosome_stability4.41149208
5MP0003111_abnormal_nucleus_morphology4.25253190
6MP0003077_abnormal_cell_cycle3.90316658
7MP0004957_abnormal_blastocyst_morpholog3.89944050
8MP0004133_heterotaxia3.69709756
9MP0001984_abnormal_olfaction3.53471008
10MP0005410_abnormal_fertilization3.46247007
11MP0003123_paternal_imprinting3.29636757
12MP0008057_abnormal_DNA_replication3.28532632
13MP0008877_abnormal_DNA_methylation3.28195089
14MP0008058_abnormal_DNA_repair3.18992312
15MP0002277_abnormal_respiratory_mucosa3.10494385
16MP0003718_maternal_effect2.94146922
17MP0000566_synostosis2.92480296
18MP0004043_abnormal_pH_regulation2.89453537
19MP0005623_abnormal_meninges_morphology2.87891888
20MP0003878_abnormal_ear_physiology2.73731882
21MP0005377_hearing/vestibular/ear_phenot2.73731882
22MP0002282_abnormal_trachea_morphology2.73271787
23MP0001929_abnormal_gametogenesis2.59552695
24MP0008789_abnormal_olfactory_epithelium2.57966214
25MP0001730_embryonic_growth_arrest2.32979429
26MP0008932_abnormal_embryonic_tissue2.32561693
27MP0008007_abnormal_cellular_replicative2.32233545
28MP0002210_abnormal_sex_determination2.29750752
29MP0003698_abnormal_male_reproductive2.04852032
30MP0001145_abnormal_male_reproductive2.02219894
31MP0003806_abnormal_nucleotide_metabolis1.99147010
32MP0000350_abnormal_cell_proliferation1.95441267
33MP0002249_abnormal_larynx_morphology1.94287676
34MP0009780_abnormal_chondrocyte_physiolo1.93804679
35MP0000653_abnormal_sex_gland1.88078473
36MP0010678_abnormal_skin_adnexa1.84324016
37MP0003786_premature_aging1.82939932
38MP0010030_abnormal_orbit_morphology1.81637822
39MP0004019_abnormal_vitamin_homeostasis1.79295646
40MP0001485_abnormal_pinna_reflex1.76369646
41MP0005083_abnormal_biliary_tract1.74695717
42MP0000678_abnormal_parathyroid_gland1.72995555
43MP0005499_abnormal_olfactory_system1.67714408
44MP0005394_taste/olfaction_phenotype1.67714408
45MP0003880_abnormal_central_pattern1.67495369
46MP0005380_embryogenesis_phenotype1.64312820
47MP0001672_abnormal_embryogenesis/_devel1.64312820
48MP0005248_abnormal_Harderian_gland1.61880271
49MP0001545_abnormal_hematopoietic_system1.54474964
50MP0005397_hematopoietic_system_phenotyp1.54474964
51MP0001697_abnormal_embryo_size1.53977257
52MP0000490_abnormal_crypts_of1.49591804
53MP0001765_abnormal_ion_homeostasis1.48794697
54MP0002161_abnormal_fertility/fecundity1.47435147
55MP0003121_genomic_imprinting1.47058647
56MP0001346_abnormal_lacrimal_gland1.44411034
57MP0006292_abnormal_olfactory_placode1.40831762
58MP0002080_prenatal_lethality1.40110350
59MP0002088_abnormal_embryonic_growth/wei1.37052633
60MP0003984_embryonic_growth_retardation1.36746568
61MP0002085_abnormal_embryonic_tissue1.34580845
62MP0002396_abnormal_hematopoietic_system1.33790440
63MP0002084_abnormal_developmental_patter1.30176602
64MP0002909_abnormal_adrenal_gland1.27416406
65MP0000313_abnormal_cell_death1.26901133
66MP0002653_abnormal_ependyma_morphology1.26823681
67MP0002102_abnormal_ear_morphology1.26454107
68MP0010307_abnormal_tumor_latency1.25825966
69MP0000049_abnormal_middle_ear1.24379318
70MP0002168_other_aberrant_phenotype1.22842354
71MP0000026_abnormal_inner_ear1.21609021
72MP0002086_abnormal_extraembryonic_tissu1.18284604
73MP0004808_abnormal_hematopoietic_stem1.18139067
74MP0000467_abnormal_esophagus_morphology1.17666572
75MP0002019_abnormal_tumor_incidence1.15956750
76MP0001119_abnormal_female_reproductive1.15461067
77MP0004197_abnormal_fetal_growth/weight/1.14757920
78MP0001293_anophthalmia1.14161570
79MP0000537_abnormal_urethra_morphology1.13385749
80MP0000534_abnormal_ureter_morphology1.12282124
81MP0002160_abnormal_reproductive_system1.11526091
82MP0009840_abnormal_foam_cell1.11339167
83MP0003315_abnormal_perineum_morphology1.11109746
84MP0005075_abnormal_melanosome_morpholog1.10849731
85MP0005171_absent_coat_pigmentation1.09274943
86MP0003567_abnormal_fetal_cardiomyocyte1.09174248
87MP0005636_abnormal_mineral_homeostasis1.07054296
88MP0005451_abnormal_body_composition1.06846424
89MP0009672_abnormal_birth_weight1.06830545
90MP0002098_abnormal_vibrissa_morphology1.06264868
91MP0003699_abnormal_female_reproductive1.05884904
92MP0003890_abnormal_embryonic-extraembry1.02976126
93MP0009333_abnormal_splenocyte_physiolog1.02780854
94MP0002233_abnormal_nose_morphology1.02101574
95MP0003221_abnormal_cardiomyocyte_apopto1.00733658
96MP0002928_abnormal_bile_duct1.00170060
97MP0005389_reproductive_system_phenotype0.98703894
98MP0002734_abnormal_mechanical_nocicepti0.98009273
99MP0002735_abnormal_chemical_nociception0.97761900
100MP0003011_delayed_dark_adaptation0.97077466
101MP0005395_other_phenotype0.96689538
102MP0003942_abnormal_urinary_system0.96265353
103MP0003186_abnormal_redox_activity0.96153208
104MP0010352_gastrointestinal_tract_polyps0.95582016
105MP0002132_abnormal_respiratory_system0.94826341
106MP0002638_abnormal_pupillary_reflex0.94680104
107MP0005253_abnormal_eye_physiology0.86770920
108MP0003938_abnormal_ear_development0.84653833
109MP0001324_abnormal_eye_pigmentation0.83103161
110MP0005551_abnormal_eye_electrophysiolog0.81107310
111MP0002722_abnormal_immune_system0.79924379
112MP0005165_increased_susceptibility_to0.78761776
113MP0002116_abnormal_craniofacial_bone0.78459713
114MP0001963_abnormal_hearing_physiology0.77858938
115MP0001764_abnormal_homeostasis0.77768690
116MP0000689_abnormal_spleen_morphology0.77652245
117MP0002896_abnormal_bone_mineralization0.77426557
118MP0009384_cardiac_valve_regurgitation0.76677272
119MP0000358_abnormal_cell_content/0.75769936
120MP0003937_abnormal_limbs/digits/tail_de0.75150899
121MP0008995_early_reproductive_senescence0.74487549
122MP0009379_abnormal_foot_pigmentation0.74203378
123MP0000703_abnormal_thymus_morphology0.73633400
124MP0002398_abnormal_bone_marrow0.72693177
125MP0002822_catalepsy0.71495823
126MP0003656_abnormal_erythrocyte_physiolo0.71172442
127MP0000955_abnormal_spinal_cord0.70816639
128MP0003861_abnormal_nervous_system0.70721525
129MP0002938_white_spotting0.69875408
130MP0003119_abnormal_digestive_system0.68581336
131MP0001727_abnormal_embryo_implantation0.68163558
132MP0005391_vision/eye_phenotype0.66926071
133MP0001486_abnormal_startle_reflex0.65828394
134MP0009703_decreased_birth_body0.64374458
135MP0005408_hypopigmentation0.64158037
136MP0002932_abnormal_joint_morphology0.63785006
137MP0005508_abnormal_skeleton_morphology0.62924129
138MP0005384_cellular_phenotype0.62051962
139MP0005360_urolithiasis0.61711358
140MP0000465_gastrointestinal_hemorrhage0.61223420
141MP0001849_ear_inflammation0.60257521
142MP0006036_abnormal_mitochondrial_physio0.60026539
143MP0003646_muscle_fatigue0.59810628
144MP0009046_muscle_twitch0.59557481
145MP0002111_abnormal_tail_morphology0.58724692
146MP0000631_abnormal_neuroendocrine_gland0.58014249
147MP0009643_abnormal_urine_homeostasis0.57775667
148MP0004264_abnormal_extraembryonic_tissu0.57727008
149MP0002136_abnormal_kidney_physiology0.55308337
150MP0009053_abnormal_anal_canal0.55220810
151MP0009278_abnormal_bone_marrow0.55179605
152MP0002139_abnormal_hepatobiliary_system0.54992188
153MP0004885_abnormal_endolymph0.54813537
154MP0005023_abnormal_wound_healing0.54755017
155MP0002429_abnormal_blood_cell0.54659632
156MP0001286_abnormal_eye_development0.54240402
157MP0001502_abnormal_circadian_rhythm0.54022533
158MP0000383_abnormal_hair_follicle0.53857537
159MP0003763_abnormal_thymus_physiology0.53825077
160MP0005621_abnormal_cell_physiology0.53312243
161MP0005670_abnormal_white_adipose0.53291465
162MP0002092_abnormal_eye_morphology0.52379588
163MP0005365_abnormal_bile_salt0.52209132
164MP0000613_abnormal_salivary_gland0.52163855
165MP0001944_abnormal_pancreas_morphology0.50735046
166MP0000477_abnormal_intestine_morphology0.50685868
167MP0009697_abnormal_copulation0.50676425
168MP0003941_abnormal_skin_development0.50472394
169MP0000598_abnormal_liver_morphology0.49913183
170MP0009765_abnormal_xenobiotic_induced0.49852079
171MP0002229_neurodegeneration0.49635635
172MP0005195_abnormal_posterior_eye0.48763093
173MP0005503_abnormal_tendon_morphology0.48117469
174MP0000778_abnormal_nervous_system0.47979481
175MP0004742_abnormal_vestibular_system0.47401521
176MP0005164_abnormal_response_to0.46632629
177MP0002557_abnormal_social/conspecific_i0.46390010

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the nasal mucosa (HP:0000433)5.35455384
2Birth length less than 3rd percentile (HP:0003561)4.94870753
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.92062973
4Breast hypoplasia (HP:0003187)4.68475287
5Absent/shortened dynein arms (HP:0200106)4.39650077
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.39650077
7Impulsivity (HP:0100710)4.11739486
8Chronic sinusitis (HP:0011109)4.06489241
9Carpal bone hypoplasia (HP:0001498)4.06375326
10Occipital encephalocele (HP:0002085)3.91069999
11Supernumerary spleens (HP:0009799)3.86061229
12Recurrent sinusitis (HP:0011108)3.80370390
13True hermaphroditism (HP:0010459)3.78412265
14Chronic bronchitis (HP:0004469)3.69774989
15Abnormal respiratory motile cilium morphology (HP:0005938)3.67404812
16Abnormal respiratory epithelium morphology (HP:0012253)3.67404812
17Abnormal respiratory motile cilium physiology (HP:0012261)3.67331074
18Recurrent otitis media (HP:0000403)3.56484666
19Rhinitis (HP:0012384)3.51062499
20Abnormal spermatogenesis (HP:0008669)3.46597023
21Cerebral hypomyelination (HP:0006808)3.41873775
22Patellar aplasia (HP:0006443)3.30537272
23Tubulointerstitial nephritis (HP:0001970)3.21925463
24Cystic liver disease (HP:0006706)3.19136775
25Nephronophthisis (HP:0000090)3.19133826
26Chromsome breakage (HP:0040012)3.16375664
27Secondary amenorrhea (HP:0000869)3.10430719
28Meckel diverticulum (HP:0002245)3.08197929
29Aplasia/Hypoplasia of the patella (HP:0006498)3.07387430
30Ureteral duplication (HP:0000073)3.05468504
31Reticulocytopenia (HP:0001896)3.00020709
32Abnormality of chromosome stability (HP:0003220)2.99014852
33Abnormality of the preputium (HP:0100587)2.95976675
34Abnormality of the ileum (HP:0001549)2.94371885
35Abnormality of cells of the erythroid lineage (HP:0012130)2.93726965
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92173858
37Abnormal number of erythroid precursors (HP:0012131)2.91248042
38Atelectasis (HP:0100750)2.85709475
39Abnormal ciliary motility (HP:0012262)2.85183841
40Colon cancer (HP:0003003)2.79335784
41Rough bone trabeculation (HP:0100670)2.78897630
42Myelodysplasia (HP:0002863)2.77601267
43Chronic hepatic failure (HP:0100626)2.77007610
44Absent thumb (HP:0009777)2.76275964
45Postaxial foot polydactyly (HP:0001830)2.74979240
46Infertility (HP:0000789)2.74617627
47Male infertility (HP:0003251)2.70950798
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68351700
49Oral leukoplakia (HP:0002745)2.62992095
50Premature ovarian failure (HP:0008209)2.62473203
51Aplastic anemia (HP:0001915)2.60680122
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.56636572
53Chronic otitis media (HP:0000389)2.56548096
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.54647516
55Bronchiectasis (HP:0002110)2.53718124
56Horseshoe kidney (HP:0000085)2.50633661
57Abnormality of the renal medulla (HP:0100957)2.48156817
58Small intestinal stenosis (HP:0012848)2.45887634
59Duodenal stenosis (HP:0100867)2.45887634
60Bone marrow hypocellularity (HP:0005528)2.45121718
6111 pairs of ribs (HP:0000878)2.40651715
62Sloping forehead (HP:0000340)2.39149979
63Azoospermia (HP:0000027)2.39111473
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37566039
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.37002196
66Degeneration of anterior horn cells (HP:0002398)2.36316138
67Abnormality of the anterior horn cell (HP:0006802)2.36316138
68Absent radius (HP:0003974)2.36195299
69Progressive muscle weakness (HP:0003323)2.34287698
70Squamous cell carcinoma (HP:0002860)2.34080689
71Hyperactive renin-angiotensin system (HP:0000841)2.32686779
72Nasal polyposis (HP:0100582)2.31743104
73Pancytopenia (HP:0001876)2.25845297
74Abnormality of cochlea (HP:0000375)2.25066315
75Anencephaly (HP:0002323)2.23725240
76Bronchitis (HP:0012387)2.23461836
77Abnormal lung lobation (HP:0002101)2.23435619
78Congenital hepatic fibrosis (HP:0002612)2.20124589
79Medial flaring of the eyebrow (HP:0010747)2.16891014
80Microretrognathia (HP:0000308)2.16789238
81Selective tooth agenesis (HP:0001592)2.15868382
82Pancreatic fibrosis (HP:0100732)2.15656706
83Breast aplasia (HP:0100783)2.15432367
84Irregular epiphyses (HP:0010582)2.14607845
85Abnormality of lateral ventricle (HP:0030047)2.13773127
86Aplasia involving forearm bones (HP:0009822)2.13693909
87Absent forearm bone (HP:0003953)2.13693909
88Macrocytic anemia (HP:0001972)2.12286037
89Bell-shaped thorax (HP:0001591)2.12035322
90Pallor (HP:0000980)2.08577439
91Sclerocornea (HP:0000647)2.08384776
92Microvesicular hepatic steatosis (HP:0001414)2.06682835
93Abnormal trabecular bone morphology (HP:0100671)2.04361486
94Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03698350
95Absent epiphyses (HP:0010577)2.03698350
96Ectopic kidney (HP:0000086)2.02595700
97Tubular atrophy (HP:0000092)2.02249753
98Aplasia/Hypoplasia of the breasts (HP:0010311)2.01914898
99Hyperglycinuria (HP:0003108)2.01036104
100Pancreatic cysts (HP:0001737)1.99455353
101Medulloblastoma (HP:0002885)1.99049566
102Male pseudohermaphroditism (HP:0000037)1.98713119
103Hypoplasia of the radius (HP:0002984)1.98073715
104Cleft eyelid (HP:0000625)1.97984874
105Abnormality of the duodenum (HP:0002246)1.96803698
106Hyperglycinemia (HP:0002154)1.96791743
107Congenital primary aphakia (HP:0007707)1.94904453
108Abnormality of pyrimidine metabolism (HP:0004353)1.94266875
109Gait imbalance (HP:0002141)1.92406843
110Prominent nose (HP:0000448)1.88192540
111Abnormality of the labia minora (HP:0012880)1.87690924
112Neoplasm of the colon (HP:0100273)1.87440323
113Personality changes (HP:0000751)1.86417298
114Molar tooth sign on MRI (HP:0002419)1.85937436
115Abnormality of midbrain morphology (HP:0002418)1.85937436
116Neoplasm of the pancreas (HP:0002894)1.85700004
117Postaxial hand polydactyly (HP:0001162)1.85469755
118Hyperkalemia (HP:0002153)1.85281077
119CNS hypomyelination (HP:0003429)1.84659860
120Oculomotor apraxia (HP:0000657)1.82037452
121Rhabdomyosarcoma (HP:0002859)1.80954441
122Short thumb (HP:0009778)1.78519707
123Furrowed tongue (HP:0000221)1.77802385
124Tubulointerstitial abnormality (HP:0001969)1.77597259
125Multiple enchondromatosis (HP:0005701)1.76957284
126Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76858956
127Facial hemangioma (HP:0000329)1.76348056
128Morphological abnormality of the inner ear (HP:0011390)1.76115581
129Abnormal biliary tract morphology (HP:0012440)1.75129992
130Stage 5 chronic kidney disease (HP:0003774)1.73895249
131Clubbing of toes (HP:0100760)1.69912394
132Broad distal phalanx of finger (HP:0009836)1.67775689
133Median cleft lip (HP:0000161)1.66840329
134Nephrogenic diabetes insipidus (HP:0009806)1.66007886
135Decreased circulating renin level (HP:0003351)1.64027969
136Preaxial hand polydactyly (HP:0001177)1.62987135
137Recurrent bronchitis (HP:0002837)1.62815196
138Nephropathy (HP:0000112)1.55458769
139Abnormality of dentin (HP:0010299)1.55368624
140Asplenia (HP:0001746)1.49270723
141Renal salt wasting (HP:0000127)1.47193034
142Genital tract atresia (HP:0001827)1.44058882
143Poor coordination (HP:0002370)1.43462088
144Vaginal atresia (HP:0000148)1.42380486
145Aplasia/Hypoplasia of the spleen (HP:0010451)1.42368132
146Abnormality of the dental root (HP:0006486)1.41009372
147Taurodontia (HP:0000679)1.41009372
148Abnormality of permanent molar morphology (HP:0011071)1.41009372
149Short nail (HP:0001799)1.40559566
150Absent frontal sinuses (HP:0002688)1.32513920
151Polydipsia (HP:0001959)1.31368796
152Abnormal drinking behavior (HP:0030082)1.31368796
153Abnormality of molar morphology (HP:0011070)1.29525115
154Abnormality of molar (HP:0011077)1.29525115
155Abnormality of the dental pulp (HP:0006479)1.25577553
156Abnormality of macular pigmentation (HP:0008002)1.24817911
157Nonprogressive disorder (HP:0003680)1.22713742
158Anophthalmia (HP:0000528)1.22184407
159Abnormal biliary tract physiology (HP:0012439)1.21820268
160Bile duct proliferation (HP:0001408)1.21820268
161Hyperaldosteronism (HP:0000859)1.21422944
162Abnormality of chloride homeostasis (HP:0011422)1.17472865
163Lip pit (HP:0100267)1.16464513
164Narrow forehead (HP:0000341)1.15183023
165Short thorax (HP:0010306)1.14782181
166Bifid scrotum (HP:0000048)1.13854779
167Renal dysplasia (HP:0000110)1.10200713
168Decreased central vision (HP:0007663)1.09956626
169Abnormality of abdominal situs (HP:0011620)1.09770985
170Abdominal situs inversus (HP:0003363)1.09770985
171Abnormality of renin-angiotensin system (HP:0000847)1.08992246
172Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.08866784
173Hyponatremia (HP:0002902)1.08335855
174Cone-rod dystrophy (HP:0000548)1.08104390
175Tubulointerstitial fibrosis (HP:0005576)1.06630473
176Aplasia of the musculature (HP:0100854)1.06615389
177Holoprosencephaly (HP:0001360)1.05677301
178Abnormality of the distal phalanges of the toes (HP:0010182)1.05104301
179Hand muscle atrophy (HP:0009130)1.04828689
180Aganglionic megacolon (HP:0002251)1.03522406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.99960472
2WEE14.08806444
3PLK43.99210222
4MST43.58938034
5CDC73.46947700
6NEK23.25665832
7TTK3.21647933
8MUSK3.07002612
9DYRK32.80803684
10PDK42.64695859
11PDK32.64695859
12MAP3K22.35987078
13PLK12.26380539
14SRPK12.22522070
15EIF2AK12.16753994
16NME22.16480378
17MAPK1511.7616234
18WNK41.91663820
19PTK2B1.90439374
20BRSK21.84210359
21NME11.81837748
22TESK11.81327401
23AURKB1.78475505
24EPHA21.73812419
25CHEK21.66840748
26CDK121.62342959
27ACVR1B1.57554480
28STK161.57376571
29STK101.52926810
30PDK21.50902546
31CDK71.46794091
32NEK11.46136227
33MAP3K31.44393347
34CCNB11.43817000
35PLK31.41868778
36EPHB11.39091773
37PASK1.38678064
38ATR1.36167082
39RPS6KA41.32227770
40RPS6KB21.29487617
41STK391.26766245
42AURKA1.26394047
43EIF2AK31.25959983
44TESK21.24307691
45STK38L1.24220889
46CHEK11.23734293
47MAP3K81.17824535
48VRK11.17445460
49MAP4K21.16823676
50NEK61.15054548
51CDK41.12866835
52BRAF1.11402835
53MAP3K41.11365096
54TSSK61.11093863
55MST1R1.10968655
56PNCK1.10020492
57EEF2K1.09177611
58BRSK11.07779733
59ZAK1.05046948
60EPHA31.04383557
61SMG10.97898515
62TNIK0.97530183
63MKNK10.95707717
64STK240.93957388
65STK380.89271710
66IRAK30.87276552
67MKNK20.87241218
68BRD40.85603843
69ATM0.83703666
70TRIB30.83544512
71PRKCI0.79848656
72TRPM70.78019237
73CSK0.76160550
74INSRR0.75607327
75TLK10.75524107
76GRK60.74821275
77PAK40.74136837
78CDK20.74057018
79LATS20.73501956
80WNK10.71837129
81MAP3K60.71440314
82DYRK1B0.69052786
83MELK0.68339207
84CDK80.68041075
85BMPR1B0.66979931
86PIM10.66725596
87PAK10.66482202
88STK30.66158147
89STK40.64928082
90MAP3K70.63991411
91CSNK2A10.63595253
92ERBB20.63343544
93TGFBR10.61610917
94CSNK2A20.60541638
95MAP2K20.57882138
96ICK0.57781283
97RPS6KA50.57190856
98PDPK10.55040237
99CDK10.54263932
100BCR0.53960977
101EIF2AK20.52858465
102MAP4K10.52079909
103MARK20.51587423
104IRAK40.50794637
105CAMKK10.49953152
106PIM20.48212656
107CDK60.45683608
108MAP2K70.45314735
109MAP2K30.44905945
110HIPK20.44752878
111CSNK1G30.44649905
112SCYL20.42371996
113TEC0.41471334
114PRKCG0.41314280
115MTOR0.39224526
116MARK30.39213456
117ERBB30.39172694
118MAPK110.38934517
119CSNK1E0.38785799
120PRKCQ0.38101508
121BTK0.37674343
122BCKDK0.36114702
123FER0.36090091
124MET0.35974984
125PRKAA20.35450740
126PRKCZ0.35430336
127GRK10.35311498
128LATS10.34861301
129PRKCD0.33780805
130ABL20.32392489
131SGK10.31825919
132MAPKAPK30.31357786
133NLK0.30782299
134AKT30.30412201
135NEK90.29675311
136RAF10.29359405
137CSNK1G10.28863290
138DYRK20.26762959
139DDR20.26734483
140TBK10.26236324
141PKN10.26043139
142PTK60.26014300
143LRRK20.25052608
144MAPKAPK50.23174163
145CAMK1G0.23077157
146PRKACA0.22722818
147AKT20.21915162
148ALK0.21357721
149CDK190.21216065
150GSK3A0.20991949
151WNK30.20104264
152CDK90.20010713
153MAP3K110.19852661
154RPS6KA10.19828587
155PDK10.19761563
156PRKAA10.18999798
157CAMK2G0.18916747
158ARAF0.18731107
159CSF1R0.18694280
160RET0.18466251
161PRKD30.18032310
162DYRK1A0.17973836
163CHUK0.17284545
164IRAK10.17231153
165ADRBK10.16662862
166PRKCA0.14374575
167CDK30.13900000
168PBK0.13275936
169PRKCE0.13022640

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.78000969
2Vitamin B6 metabolism_Homo sapiens_hsa007503.84072982
3DNA replication_Homo sapiens_hsa030303.72626321
4Tyrosine metabolism_Homo sapiens_hsa003503.72624873
5Mismatch repair_Homo sapiens_hsa034303.66302346
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54024905
7RNA polymerase_Homo sapiens_hsa030203.50809471
8RNA transport_Homo sapiens_hsa030133.31257400
9Proteasome_Homo sapiens_hsa030503.26019172
10Basal transcription factors_Homo sapiens_hsa030222.86649297
11Spliceosome_Homo sapiens_hsa030402.86170719
12Cell cycle_Homo sapiens_hsa041102.75784415
13Homologous recombination_Homo sapiens_hsa034402.74197256
14Ribosome_Homo sapiens_hsa030102.62871129
15Base excision repair_Homo sapiens_hsa034102.57340497
16Pyrimidine metabolism_Homo sapiens_hsa002402.41064449
17Fanconi anemia pathway_Homo sapiens_hsa034602.36651218
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30855661
19Nucleotide excision repair_Homo sapiens_hsa034202.21758563
20mRNA surveillance pathway_Homo sapiens_hsa030152.04987452
21One carbon pool by folate_Homo sapiens_hsa006701.94693016
22RNA degradation_Homo sapiens_hsa030181.92028729
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85182346
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.83996361
25Non-homologous end-joining_Homo sapiens_hsa034501.82270782
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65697681
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64023981
28Folate biosynthesis_Homo sapiens_hsa007901.63553513
29p53 signaling pathway_Homo sapiens_hsa041151.60416329
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59314803
31Tight junction_Homo sapiens_hsa045301.58939198
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58505985
33Purine metabolism_Homo sapiens_hsa002301.57514189
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54166729
35Hedgehog signaling pathway_Homo sapiens_hsa043401.53933747
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.50726748
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44484802
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.40007884
39Selenocompound metabolism_Homo sapiens_hsa004501.38745311
40Pentose phosphate pathway_Homo sapiens_hsa000301.36915545
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36551870
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.32099114
43Oocyte meiosis_Homo sapiens_hsa041141.26007360
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14734710
45Sphingolipid metabolism_Homo sapiens_hsa006001.09575555
46Epstein-Barr virus infection_Homo sapiens_hsa051691.09564377
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.09152373
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00536051
49Glutathione metabolism_Homo sapiens_hsa004800.97067921
50Olfactory transduction_Homo sapiens_hsa047400.96924116
51Biosynthesis of amino acids_Homo sapiens_hsa012300.96031159
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93397710
53Salivary secretion_Homo sapiens_hsa049700.92966952
54Cocaine addiction_Homo sapiens_hsa050300.92810971
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92740605
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91714433
57ABC transporters_Homo sapiens_hsa020100.90143237
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87658788
59Phototransduction_Homo sapiens_hsa047440.85909272
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84513424
61Linoleic acid metabolism_Homo sapiens_hsa005910.84332970
62Systemic lupus erythematosus_Homo sapiens_hsa053220.80752523
63Circadian rhythm_Homo sapiens_hsa047100.78606189
64Pyruvate metabolism_Homo sapiens_hsa006200.78012815
65Taste transduction_Homo sapiens_hsa047420.76152918
66Carbon metabolism_Homo sapiens_hsa012000.74737287
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71420281
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68757271
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68519993
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68255702
71Oxidative phosphorylation_Homo sapiens_hsa001900.67120257
72Cardiac muscle contraction_Homo sapiens_hsa042600.66707052
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.65278040
74Viral carcinogenesis_Homo sapiens_hsa052030.65032004
75Butanoate metabolism_Homo sapiens_hsa006500.61162825
76Huntingtons disease_Homo sapiens_hsa050160.61121301
77Protein export_Homo sapiens_hsa030600.60509286
78Arachidonic acid metabolism_Homo sapiens_hsa005900.60325592
79Antigen processing and presentation_Homo sapiens_hsa046120.60093028
80N-Glycan biosynthesis_Homo sapiens_hsa005100.59572434
81Herpes simplex infection_Homo sapiens_hsa051680.58609920
82Collecting duct acid secretion_Homo sapiens_hsa049660.56994638
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56678915
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.56380246
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55200024
86Calcium signaling pathway_Homo sapiens_hsa040200.54445564
87cAMP signaling pathway_Homo sapiens_hsa040240.54341479
88Propanoate metabolism_Homo sapiens_hsa006400.50724985
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49327613
90Starch and sucrose metabolism_Homo sapiens_hsa005000.48448860
91Metabolic pathways_Homo sapiens_hsa011000.47398555
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45367086
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42719330
94Parkinsons disease_Homo sapiens_hsa050120.41804577
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41622593
96Regulation of autophagy_Homo sapiens_hsa041400.40396267
97Fructose and mannose metabolism_Homo sapiens_hsa000510.39764611
98HTLV-I infection_Homo sapiens_hsa051660.39614764
99Sulfur relay system_Homo sapiens_hsa041220.39538840
100PPAR signaling pathway_Homo sapiens_hsa033200.39118552
101Nicotine addiction_Homo sapiens_hsa050330.39062435
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38057580
103Axon guidance_Homo sapiens_hsa043600.37222420
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35771801
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35342277
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35065506
107Amphetamine addiction_Homo sapiens_hsa050310.34154263
108Thyroid cancer_Homo sapiens_hsa052160.33766070
109Hepatitis C_Homo sapiens_hsa051600.33359787
110Glycerolipid metabolism_Homo sapiens_hsa005610.32423898
111Alzheimers disease_Homo sapiens_hsa050100.32397783
112Caffeine metabolism_Homo sapiens_hsa002320.31301792
113Chemical carcinogenesis_Homo sapiens_hsa052040.30907377
114Nitrogen metabolism_Homo sapiens_hsa009100.29179330
115TGF-beta signaling pathway_Homo sapiens_hsa043500.27970509
116Prostate cancer_Homo sapiens_hsa052150.27857500
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26570103
118MicroRNAs in cancer_Homo sapiens_hsa052060.25789648
119Steroid biosynthesis_Homo sapiens_hsa001000.23637771
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22855969
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22704921
122Hippo signaling pathway_Homo sapiens_hsa043900.22468632
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22218779
124Melanogenesis_Homo sapiens_hsa049160.21510568
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20950414
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20247952
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20001209
128Notch signaling pathway_Homo sapiens_hsa043300.19898107
129beta-Alanine metabolism_Homo sapiens_hsa004100.19735265
130Choline metabolism in cancer_Homo sapiens_hsa052310.19651879
131Peroxisome_Homo sapiens_hsa041460.19295167
132Bile secretion_Homo sapiens_hsa049760.18779843
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18567100
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.18312825
135Arginine and proline metabolism_Homo sapiens_hsa003300.18174674
136Vitamin digestion and absorption_Homo sapiens_hsa049770.17748459
137Ether lipid metabolism_Homo sapiens_hsa005650.17351105
138Legionellosis_Homo sapiens_hsa051340.17125371
139Histidine metabolism_Homo sapiens_hsa003400.16686946
140Arginine biosynthesis_Homo sapiens_hsa002200.16535570
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.15644122
142Galactose metabolism_Homo sapiens_hsa000520.14397668
143Adherens junction_Homo sapiens_hsa045200.13614975
144Retinol metabolism_Homo sapiens_hsa008300.13404215
145Wnt signaling pathway_Homo sapiens_hsa043100.12880004
146Small cell lung cancer_Homo sapiens_hsa052220.12506410
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.12325931
148Fatty acid degradation_Homo sapiens_hsa000710.12218466
149Fatty acid biosynthesis_Homo sapiens_hsa000610.12025392
150Primary immunodeficiency_Homo sapiens_hsa053400.11258310
151Complement and coagulation cascades_Homo sapiens_hsa046100.11025053
152Mineral absorption_Homo sapiens_hsa049780.10833614
153Acute myeloid leukemia_Homo sapiens_hsa052210.10196516
154Alcoholism_Homo sapiens_hsa050340.09925084
155Gap junction_Homo sapiens_hsa045400.09126424
156Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08819355
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08388309
158Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.07926136
159Basal cell carcinoma_Homo sapiens_hsa052170.07565981
160Type II diabetes mellitus_Homo sapiens_hsa049300.07494152

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