RIC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.82155809
2positive regulation of interferon-alpha production (GO:0032727)4.64191147
3regulation of interferon-alpha production (GO:0032647)4.39036756
4regulation of RIG-I signaling pathway (GO:0039535)4.26167114
5positive regulation of gamma-delta T cell activation (GO:0046645)4.13886126
6bone remodeling (GO:0046849)3.72910011
7regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.67980451
8cellular response to virus (GO:0098586)3.59907145
9response to muramyl dipeptide (GO:0032495)3.56130310
10B cell receptor signaling pathway (GO:0050853)3.55415760
11embryonic process involved in female pregnancy (GO:0060136)3.40605948
12detection of molecule of bacterial origin (GO:0032490)3.38968109
13regulation of B cell receptor signaling pathway (GO:0050855)3.38616438
14growth hormone receptor signaling pathway (GO:0060396)3.32482323
15Rap protein signal transduction (GO:0032486)3.29679752
16regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.16469119
17regulation of pigment cell differentiation (GO:0050932)3.14199078
18positive regulation of interferon-beta production (GO:0032728)3.13057744
19nuclear pore organization (GO:0006999)3.07876492
20positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.04380316
21neutrophil activation involved in immune response (GO:0002283)3.03893468
22cellular extravasation (GO:0045123)3.03760088
23CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.02959663
24myeloid dendritic cell activation (GO:0001773)3.02608108
25myoblast migration (GO:0051451)2.98744249
26positive regulation of smooth muscle cell migration (GO:0014911)2.98453126
27positive regulation of natural killer cell differentiation (GO:0032825)2.98252400
28negative regulation of osteoblast proliferation (GO:0033689)2.95938104
29positive regulation of bone remodeling (GO:0046852)2.95913363
30positive regulation of bone resorption (GO:0045780)2.95913363
31negative regulation of erythrocyte differentiation (GO:0045647)2.95236990
32hypotonic response (GO:0006971)2.95118032
33T cell lineage commitment (GO:0002360)2.95104067
34myeloid dendritic cell differentiation (GO:0043011)2.94695216
35macrophage activation involved in immune response (GO:0002281)2.94364763
36granulocyte activation (GO:0036230)2.93724523
37regulation of interleukin-12 biosynthetic process (GO:0045075)2.89899788
38negative regulation of DNA repair (GO:0045738)2.89076080
39regulation of histone H3-K27 methylation (GO:0061085)2.88930679
40phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.86701907
41positive regulation of cellular amide metabolic process (GO:0034250)2.84408016
42positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.83318302
43N-acetylneuraminate metabolic process (GO:0006054)2.82585261
44regulation of gamma-delta T cell activation (GO:0046643)2.82262350
45pinocytosis (GO:0006907)2.81868761
46response to laminar fluid shear stress (GO:0034616)2.78196681
47mesenchymal-epithelial cell signaling (GO:0060638)2.78169046
48cellular response to growth hormone stimulus (GO:0071378)2.77421672
49negative regulation of bone mineralization (GO:0030502)2.76284586
50morphogenesis of an epithelial sheet (GO:0002011)2.75587145
51dendritic cell chemotaxis (GO:0002407)2.75152473
52positive regulation of B cell differentiation (GO:0045579)2.74486986
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74367214
54neutrophil activation (GO:0042119)2.73914028
55pore complex assembly (GO:0046931)2.72117002
56positive regulation of response to biotic stimulus (GO:0002833)2.71855212
57germinal center formation (GO:0002467)2.70248134
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69897022
59detection of external biotic stimulus (GO:0098581)2.69587452
60histone H3-K36 demethylation (GO:0070544)2.68878227
61regulation of T-helper 1 cell differentiation (GO:0045625)2.68517838
62mannose metabolic process (GO:0006013)2.67397863
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67390746
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65050121
65negative regulation of cell killing (GO:0031342)2.65050121
66regulation of macrophage cytokine production (GO:0010935)2.64908771
67cell-substrate adherens junction assembly (GO:0007045)2.64906309
68focal adhesion assembly (GO:0048041)2.64906309
69positive regulation of interleukin-12 production (GO:0032735)2.64766784
70B cell homeostasis (GO:0001782)2.64305269
71antigen processing and presentation of endogenous antigen (GO:0019883)2.63887169
72cell-substrate junction assembly (GO:0007044)2.63792191
73cellular response to ethanol (GO:0071361)2.63315209
74detection of other organism (GO:0098543)2.62927623
75regulation of necroptotic process (GO:0060544)2.62776726
76regulation of interferon-beta biosynthetic process (GO:0045357)2.62094851
77T-helper cell differentiation (GO:0042093)2.61360815
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.61360815
79nuclear pore complex assembly (GO:0051292)2.60532651
80pericardium development (GO:0060039)2.59054231
81Notch signaling involved in heart development (GO:0061314)2.54495414
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54167033
83response to host (GO:0075136)2.54167033
84response to host defenses (GO:0052200)2.54167033
85dendritic cell migration (GO:0036336)2.51911005
86melanin metabolic process (GO:0006582)2.51795048
87superoxide anion generation (GO:0042554)2.51729246
88negative regulation of viral genome replication (GO:0045071)2.50825899
89regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.50632247
90negative regulation of myeloid cell apoptotic process (GO:0033033)2.50588354
91NIK/NF-kappaB signaling (GO:0038061)2.49644270
92regulation of type I interferon-mediated signaling pathway (GO:0060338)2.49119877
93negative regulation of interleukin-12 production (GO:0032695)2.48930960
94regulation of RNA export from nucleus (GO:0046831)2.48679022
95negative thymic T cell selection (GO:0045060)2.47878800
96regulation of B cell differentiation (GO:0045577)2.47224287
97B cell proliferation (GO:0042100)2.45642138
98negative regulation of fatty acid transport (GO:2000192)2.45491404
99glomerulus development (GO:0032835)2.44925990
100protein localization to endosome (GO:0036010)2.44896238
101regulation of protein heterodimerization activity (GO:0043497)2.42392521
102positive regulation of heat generation (GO:0031652)2.42132456
103I-kappaB phosphorylation (GO:0007252)2.41910484
104positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.41251234
105regulation of fever generation (GO:0031620)2.40682867
106stress fiber assembly (GO:0043149)2.40419456
107regulation of protein polyubiquitination (GO:1902914)2.39432295
108negative regulation of anoikis (GO:2000811)2.39303033
109T cell migration (GO:0072678)2.39075704
110regulation of gamma-delta T cell differentiation (GO:0045586)2.38953133
111myelin assembly (GO:0032288)2.38628826
112positive regulation by symbiont of host defense response (GO:0052509)2.38360286
113modulation by symbiont of host defense response (GO:0052031)2.38360286
114modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38360286
115modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38360286
116positive regulation by organism of defense response of other organism involved in symbiotic interact2.38360286
117modulation by symbiont of host immune response (GO:0052553)2.38360286
118sequestering of extracellular ligand from receptor (GO:0035581)2.37906432
119histone H3-K9 demethylation (GO:0033169)2.37895446
120T-helper 1 type immune response (GO:0042088)2.37564422
121detection of biotic stimulus (GO:0009595)2.37243447
122negative regulation of biomineral tissue development (GO:0070168)2.36569235
123positive regulation of mRNA catabolic process (GO:0061014)2.36501843
124regulation of nucleobase-containing compound transport (GO:0032239)2.35059198
125cortical actin cytoskeleton organization (GO:0030866)2.34660088
126hepatocyte apoptotic process (GO:0097284)2.34527879
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.33739462
128ear development (GO:0043583)2.33726017
129positive regulation of macrophage cytokine production (GO:0060907)2.33450581
130detection of bacterium (GO:0016045)2.33164813
131adherens junction assembly (GO:0034333)2.32946830
132cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.32754959
133skin morphogenesis (GO:0043589)2.31028697
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.30561884
135response to host immune response (GO:0052572)2.30561884
136COPII vesicle coating (GO:0048208)2.29364674
137response to peptidoglycan (GO:0032494)2.29353474
138interferon-gamma-mediated signaling pathway (GO:0060333)2.29185025
139positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.29148853
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.29122982
141interkinetic nuclear migration (GO:0022027)2.28811381
142positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.28780426
143regulation of fibroblast apoptotic process (GO:2000269)2.28277962
144positive regulation of developmental pigmentation (GO:0048087)2.28181250
145retinal cone cell development (GO:0046549)2.27452966
146definitive hemopoiesis (GO:0060216)2.26611667
147cytoplasmic mRNA processing body assembly (GO:0033962)2.25621277
148positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.25509487
149spleen development (GO:0048536)2.25187373
150platelet-derived growth factor receptor signaling pathway (GO:0048008)2.24556501
151positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.24526432
152negative T cell selection (GO:0043383)2.24491382
153regulation of activation of Janus kinase activity (GO:0010533)2.23695370
154histone lysine demethylation (GO:0070076)2.23639305
155chondrocyte development (GO:0002063)2.23420821
156regulation of interferon-beta production (GO:0032648)2.23047349
157JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.22858767
158regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.22801359
159response to type I interferon (GO:0034340)2.22742547
160collagen fibril organization (GO:0030199)2.22569110
161cytokine secretion (GO:0050663)2.21924761
162cellular response to type I interferon (GO:0071357)2.21579079
163type I interferon signaling pathway (GO:0060337)2.21579079
164histone demethylation (GO:0016577)2.20833754
165phospholipid translocation (GO:0045332)2.20601363
166lipid translocation (GO:0034204)2.20601363
167membrane raft organization (GO:0031579)2.20253446
168mesenchymal cell development (GO:0014031)2.19824484
169negative regulation of chondrocyte differentiation (GO:0032331)2.18738523
170neural tube formation (GO:0001841)2.18643922
171alpha-beta T cell differentiation involved in immune response (GO:0002293)2.18489013
172alpha-beta T cell activation involved in immune response (GO:0002287)2.18489013
173T cell differentiation involved in immune response (GO:0002292)2.18489013
174pathway-restricted SMAD protein phosphorylation (GO:0060389)2.17018059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.74781225
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.59549690
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.62155044
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.24633557
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.99243909
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.81984134
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64062998
8MYC_22102868_ChIP-Seq_BL_Human2.63452080
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61084326
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59489923
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.32281796
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29691385
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19047645
14VDR_24787735_ChIP-Seq_THP-1_Human2.08074672
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.06587513
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.00930753
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98757692
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.95069587
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87955740
20AR_21572438_ChIP-Seq_LNCaP_Human1.87287608
21TCF7_22412390_ChIP-Seq_EML_Mouse1.82056303
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80058985
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79445711
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77471282
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77468418
26NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.76402159
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74541793
28MYB_26560356_Chip-Seq_TH1_Human1.74087746
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72874414
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.70452283
31RUNX_20019798_ChIP-Seq_JUKART_Human1.69912907
32VDR_24763502_ChIP-Seq_THP-1_Human1.65040611
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62414132
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61765992
35MAF_26560356_Chip-Seq_TH1_Human1.60247082
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59323735
37VDR_21846776_ChIP-Seq_THP-1_Human1.59171468
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58740446
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57181713
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54118480
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53541973
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52763473
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52530566
44GBX2_23144817_ChIP-Seq_PC3_Human1.51763468
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.49771687
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49034574
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49034574
48CLOCK_20551151_ChIP-Seq_293T_Human1.48732400
49SPI1_23127762_ChIP-Seq_K562_Human1.48473308
50RXR_22108803_ChIP-Seq_LS180_Human1.45486878
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45131785
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44846892
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.40852678
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39926169
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38328851
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37570410
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36744236
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36623800
59AHR_22903824_ChIP-Seq_MCF-7_Human1.36533435
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34903612
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34135366
62TP53_16413492_ChIP-PET_HCT116_Human1.33615682
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32966284
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32606905
65SPI1_23547873_ChIP-Seq_NB4_Human1.32449424
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32430062
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31997911
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.31376375
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31268816
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31268816
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.29852043
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29305600
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27561704
74TCF4_18268006_ChIP-ChIP_LS174T_Human1.27248299
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.27235587
76KDM2B_26808549_Chip-Seq_DND41_Human1.27230455
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24123825
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24059276
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23008238
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.22095175
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20953420
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.18436292
83IGF1R_20145208_ChIP-Seq_DFB_Human1.18349254
84TP53_18474530_ChIP-ChIP_U2OS_Human1.18328749
85PU_27001747_Chip-Seq_BMDM_Mouse1.17842820
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17535748
87SCL_19346495_ChIP-Seq_HPC-7_Human1.17429950
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16741913
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15733031
90ER_23166858_ChIP-Seq_MCF-7_Human1.15650675
91UTX_26944678_Chip-Seq_JUKART_Human1.15132518
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14928185
93CJUN_26792858_Chip-Seq_BT549_Human1.14317910
94P300_19829295_ChIP-Seq_ESCs_Human1.13418379
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13040588
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.12908142
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12648987
98GATA1_22025678_ChIP-Seq_K562_Human1.11480886
99ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11344381
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11259724
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10989378
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10781214
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10470695
104BRD4_25478319_ChIP-Seq_HGPS_Human1.10315244
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10039876
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.09867438
107GATA1_19941826_ChIP-Seq_K562_Human1.09607360
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.08285325
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08265212
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.07622808
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07413232
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.07410773
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07400765
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.06953798
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06803946
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05576035
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.05473532
118SMAD4_21799915_ChIP-Seq_A2780_Human1.05455329
119STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03903506
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.03263771
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.02907005
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01961940
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01079504
124TBX20_22080862_ChIP-Seq_HEART_Mouse1.00956847
125TBX20_22328084_ChIP-Seq_HEART_Mouse1.00956847
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00077459
127GATA2_19941826_ChIP-Seq_K562_Human0.98919617
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.98359302
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97306882
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97049321
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96935965
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96233951
133P53_22387025_ChIP-Seq_ESCs_Mouse0.95722507
134GATA3_27048872_Chip-Seq_THYMUS_Human0.95207041
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94365054
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.93914422
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93637415
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.93246213
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92803271
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92587593
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92124053
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91653223
143STAT3_23295773_ChIP-Seq_U87_Human0.91537941
144PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90272471
145SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87577010
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87461806
147EP300_21415370_ChIP-Seq_HL-1_Mouse0.87111816
148P300_18555785_Chip-Seq_ESCs_Mouse0.86914705
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85965151
150RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85376728
151MYB_26560356_Chip-Seq_TH2_Human0.85254381
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84966751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.14082263
2MP0002009_preneoplasia2.99728951
3MP0001348_abnormal_lacrimal_gland2.91938620
4MP0001835_abnormal_antigen_presentation2.84027259
5MP0000372_irregular_coat_pigmentation2.83156648
6MP0005275_abnormal_skin_tensile2.77944166
7MP0004381_abnormal_hair_follicle2.68635348
8MP0003300_gastrointestinal_ulcer2.65586937
9MP0002138_abnormal_hepatobiliary_system2.57824161
10MP0005408_hypopigmentation2.45703935
11MP0000569_abnormal_digit_pigmentation2.45000123
12MP0002006_tumorigenesis2.40925290
13MP0003724_increased_susceptibility_to2.38949467
14MP0003303_peritoneal_inflammation2.32872053
15MP0010352_gastrointestinal_tract_polyps2.32264626
16MP0002148_abnormal_hypersensitivity_rea2.32040112
17MP0002166_altered_tumor_susceptibility2.29053835
18MP0008057_abnormal_DNA_replication2.27442283
19MP0003566_abnormal_cell_adhesion2.19099900
20MP0003436_decreased_susceptibility_to2.09317958
21MP0005671_abnormal_response_to2.07544865
22MP0002396_abnormal_hematopoietic_system2.04390415
23MP0004510_myositis2.01308707
24MP0002254_reproductive_system_inflammat2.00162195
25MP0002877_abnormal_melanocyte_morpholog1.93748609
26MP0009785_altered_susceptibility_to1.93035465
27MP0005451_abnormal_body_composition1.89485296
28MP0003136_yellow_coat_color1.88973398
29MP0005000_abnormal_immune_tolerance1.87492437
30MP0003279_aneurysm1.86318313
31MP0001958_emphysema1.80289452
32MP0003950_abnormal_plasma_membrane1.77883820
33MP0001790_abnormal_immune_system1.72444819
34MP0005387_immune_system_phenotype1.72444819
35MP0002419_abnormal_innate_immunity1.69716201
36MP0005171_absent_coat_pigmentation1.69514226
37MP0002452_abnormal_antigen_presenting1.68699208
38MP0004808_abnormal_hematopoietic_stem1.67217824
39MP0002998_abnormal_bone_remodeling1.66589247
40MP0006054_spinal_hemorrhage1.66018228
41MP0000371_diluted_coat_color1.64814286
42MP0005076_abnormal_cell_differentiation1.61403414
43MP0003091_abnormal_cell_migration1.54363815
44MP0000767_abnormal_smooth_muscle1.53018334
45MP0005075_abnormal_melanosome_morpholog1.52957605
46MP0000015_abnormal_ear_pigmentation1.51079364
47MP0001800_abnormal_humoral_immune1.46210772
48MP0005503_abnormal_tendon_morphology1.45757247
49MP0005257_abnormal_intraocular_pressure1.44322336
50MP0002933_joint_inflammation1.44255344
51MP0008438_abnormal_cutaneous_collagen1.43527362
52MP0002723_abnormal_immune_serum1.42952496
53MP0001346_abnormal_lacrimal_gland1.41418510
54MP0002177_abnormal_outer_ear1.40593736
55MP0000566_synostosis1.39139707
56MP0005025_abnormal_response_to1.36641207
57MP0000685_abnormal_immune_system1.35937399
58MP0001819_abnormal_immune_cell1.34767085
59MP0005023_abnormal_wound_healing1.30376783
60MP0003453_abnormal_keratinocyte_physiol1.29977016
61MP0002277_abnormal_respiratory_mucosa1.29952954
62MP0002420_abnormal_adaptive_immunity1.29824589
63MP0003385_abnormal_body_wall1.29586992
64MP0002928_abnormal_bile_duct1.28466517
65MP0001879_abnormal_lymphatic_vessel1.28042536
66MP0003191_abnormal_cellular_cholesterol1.25562252
67MP0003941_abnormal_skin_development1.24973970
68MP0002168_other_aberrant_phenotype1.24750427
69MP0010234_abnormal_vibrissa_follicle1.22913186
70MP0001324_abnormal_eye_pigmentation1.21354618
71MP0001188_hyperpigmentation1.19116319
72MP0003448_altered_tumor_morphology1.18676533
73MP0003828_pulmonary_edema1.17770233
74MP0002163_abnormal_gland_morphology1.17629542
75MP0004782_abnormal_surfactant_physiolog1.16504813
76MP0000858_altered_metastatic_potential1.15403242
77MP0005248_abnormal_Harderian_gland1.14654416
78MP0008260_abnormal_autophagy1.14332993
79MP0005623_abnormal_meninges_morphology1.13614662
80MP0000516_abnormal_urinary_system1.12783099
81MP0005367_renal/urinary_system_phenotyp1.12783099
82MP0009333_abnormal_splenocyte_physiolog1.12100714
83MP0003763_abnormal_thymus_physiology1.11601856
84MP0005621_abnormal_cell_physiology1.09926772
85MP0003656_abnormal_erythrocyte_physiolo1.09238829
86MP0005164_abnormal_response_to1.08351471
87MP0009764_decreased_sensitivity_to1.05707600
88MP0001853_heart_inflammation1.05464497
89MP0002075_abnormal_coat/hair_pigmentati1.03528156
90MP0002095_abnormal_skin_pigmentation1.02389593
91MP0001851_eye_inflammation1.01777521
92MP0001533_abnormal_skeleton_physiology1.01519607
93MP0000733_abnormal_muscle_development1.01024335
94MP0004883_abnormal_blood_vessel1.00971125
95MP0010307_abnormal_tumor_latency1.00385295
96MP0002722_abnormal_immune_system0.99764035
97MP0003942_abnormal_urinary_system0.99577312
98MP0001186_pigmentation_phenotype0.99308308
99MP0003172_abnormal_lysosome_physiology0.99084083
100MP0000703_abnormal_thymus_morphology0.97624226
101MP0003221_abnormal_cardiomyocyte_apopto0.97451043
102MP0000689_abnormal_spleen_morphology0.96607886
103MP0001661_extended_life_span0.95601012
104MP0003943_abnormal_hepatobiliary_system0.95531818
105MP0003045_fibrosis0.95131980
106MP0000716_abnormal_immune_system0.93668092
107MP0005310_abnormal_salivary_gland0.93494759
108MP0001915_intracranial_hemorrhage0.91589581
109MP0009250_abnormal_appendicular_skeleto0.91407979
110MP0002429_abnormal_blood_cell0.90456029
111MP0000432_abnormal_head_morphology0.89577861
112MP0005197_abnormal_uvea_morphology0.89156125
113MP0005390_skeleton_phenotype0.88970709
114MP0008004_abnormal_stomach_pH0.88617505
115MP0002405_respiratory_system_inflammati0.87629845
116MP0005058_abnormal_lysosome_morphology0.87547384
117MP0000465_gastrointestinal_hemorrhage0.86728963
118MP0009697_abnormal_copulation0.86648542
119MP0002398_abnormal_bone_marrow0.85900022
120MP0005409_darkened_coat_color0.84008238
121MP0000627_abnormal_mammary_gland0.82646373
122MP0004947_skin_inflammation0.82237006
123MP0003252_abnormal_bile_duct0.82226128
124MP0010155_abnormal_intestine_physiology0.81234933
125MP0004185_abnormal_adipocyte_glucose0.79645790
126MP0005174_abnormal_tail_pigmentation0.79097001
127MP0001919_abnormal_reproductive_system0.78862446
128MP0005551_abnormal_eye_electrophysiolog0.78774612
129MP0001545_abnormal_hematopoietic_system0.78331834
130MP0005397_hematopoietic_system_phenotyp0.78331834
131MP0004084_abnormal_cardiac_muscle0.77541735
132MP0002060_abnormal_skin_morphology0.77138390
133MP0002086_abnormal_extraembryonic_tissu0.76546422
134MP0005464_abnormal_platelet_physiology0.76223002
135MP0005395_other_phenotype0.75303937
136MP0003011_delayed_dark_adaptation0.73564219
137MP0001845_abnormal_inflammatory_respons0.73401902
138MP0002092_abnormal_eye_morphology0.72142467
139MP0002896_abnormal_bone_mineralization0.72099850
140MP0005084_abnormal_gallbladder_morpholo0.71241541
141MP0004272_abnormal_basement_membrane0.71170801
142MP0003795_abnormal_bone_structure0.69603111
143MP0001849_ear_inflammation0.69395973
144MP0002128_abnormal_blood_circulation0.69391172
145MP0000003_abnormal_adipose_tissue0.69382113
146MP0003868_abnormal_feces_composition0.68597668
147MP0009278_abnormal_bone_marrow0.68105708

Predicted human phenotypes

RankGene SetZ-score
1Spinal cord lesions (HP:0100561)4.58618283
2Syringomyelia (HP:0003396)4.58618283
3Mediastinal lymphadenopathy (HP:0100721)3.92089985
4Absent frontal sinuses (HP:0002688)3.83877547
5Protrusio acetabuli (HP:0003179)3.72982436
6Aortic aneurysm (HP:0004942)3.63149090
7Aortic dissection (HP:0002647)3.55097338
8Chorioretinal atrophy (HP:0000533)3.43729903
9Spondylolisthesis (HP:0003302)3.22137950
10Eczematoid dermatitis (HP:0000976)3.15434991
11Oligodontia (HP:0000677)3.07101492
12Retrobulbar optic neuritis (HP:0100654)2.95250261
13Optic neuritis (HP:0100653)2.95250261
14Myocardial infarction (HP:0001658)2.94898840
15Abnormality of the nasal septum (HP:0000419)2.94145877
16Midline defect of the nose (HP:0004122)2.93346788
17Pigmentary retinal degeneration (HP:0001146)2.87889840
18Recurrent abscess formation (HP:0002722)2.87677199
19Arterial tortuosity (HP:0005116)2.86166889
20Dilatation of the ascending aorta (HP:0005111)2.84933941
21Vascular tortuosity (HP:0004948)2.84518155
22Abnormality of the fingertips (HP:0001211)2.73064949
23Recurrent bacterial skin infections (HP:0005406)2.72465152
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.71858982
25Osteolytic defects of the hand bones (HP:0009699)2.71858982
26Periodontitis (HP:0000704)2.69563166
27Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.68215218
28Abnormality of the frontal sinuses (HP:0002687)2.67991861
29Mitral valve prolapse (HP:0001634)2.65755851
30Congenital stationary night blindness (HP:0007642)2.63736428
31Colitis (HP:0002583)2.58199549
32Recurrent gram-negative bacterial infections (HP:0005420)2.56456539
33Autoimmune thrombocytopenia (HP:0001973)2.54698729
34Vertebral compression fractures (HP:0002953)2.54430119
35Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.54121155
36Selective tooth agenesis (HP:0001592)2.53972996
37Stomatitis (HP:0010280)2.52592305
38Abnormality of the peritoneum (HP:0002585)2.52503475
39Overgrowth (HP:0001548)2.50566136
40Orchitis (HP:0100796)2.48888301
41Gastrointestinal infarctions (HP:0005244)2.42477374
42Thoracolumbar scoliosis (HP:0002944)2.40444983
43Pulmonary artery stenosis (HP:0004415)2.40274741
44Spontaneous hematomas (HP:0007420)2.37731891
45Thick nail (HP:0001805)2.36217643
46Pulmonary infiltrates (HP:0002113)2.35979391
47Mitral stenosis (HP:0001718)2.32858233
48Narrow palate (HP:0000189)2.32098252
49Arterial thrombosis (HP:0004420)2.29536285
50Recurrent fungal infections (HP:0002841)2.29099295
51Wormian bones (HP:0002645)2.28456018
52Asymmetry of the thorax (HP:0001555)2.28014345
53Cerebral aneurysm (HP:0004944)2.27342141
54Persistence of primary teeth (HP:0006335)2.27224587
55Alveolar cell carcinoma (HP:0006519)2.27146311
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26135445
57Dyschromatopsia (HP:0007641)2.23507658
58Viral hepatitis (HP:0006562)2.23375121
59Gingivitis (HP:0000230)2.20297682
60Myositis (HP:0100614)2.19853455
61Neoplasm of the tracheobronchial system (HP:0100552)2.19487303
62Aneurysm (HP:0002617)2.16840956
63Meningitis (HP:0001287)2.16667344
64Prostate neoplasm (HP:0100787)2.15836555
65Vasculitis (HP:0002633)2.15261825
66Genu recurvatum (HP:0002816)2.14426214
67Emphysema (HP:0002097)2.12619407
68Soft skin (HP:0000977)2.10850625
69Attenuation of retinal blood vessels (HP:0007843)2.09009047
70Gingival bleeding (HP:0000225)2.08490769
71Abnormality of the phalanges of the hallux (HP:0010057)2.07565350
72Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.06555478
73Porencephaly (HP:0002132)2.04181282
74Gastrointestinal stroma tumor (HP:0100723)2.04157524
75Acute myeloid leukemia (HP:0004808)2.04065437
76Submucous cleft hard palate (HP:0000176)2.03892611
77Hematochezia (HP:0002573)2.01955236
78Basal ganglia calcification (HP:0002135)1.99733574
79Agammaglobulinemia (HP:0004432)1.98704995
80Bladder diverticulum (HP:0000015)1.97624456
81Short nail (HP:0001799)1.97214991
82Blue sclerae (HP:0000592)1.97077446
83Lip pit (HP:0100267)1.95779442
84Congenital sensorineural hearing impairment (HP:0008527)1.93692225
85Large earlobe (HP:0009748)1.93411606
86Dislocated radial head (HP:0003083)1.93192126
87Cellulitis (HP:0100658)1.92411928
88Follicular hyperkeratosis (HP:0007502)1.90320226
89Increased variability in muscle fiber diameter (HP:0003557)1.89632956
90Recurrent skin infections (HP:0001581)1.88994653
91IgA deficiency (HP:0002720)1.88560382
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88382850
93Short 4th metacarpal (HP:0010044)1.88382850
94Broad ribs (HP:0000885)1.87924282
95Chronic mucocutaneous candidiasis (HP:0002728)1.87880933
96Recurrent cutaneous fungal infections (HP:0011370)1.87880933
97T lymphocytopenia (HP:0005403)1.87265925
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.86538086
99Peritonitis (HP:0002586)1.86404681
100Thyroiditis (HP:0100646)1.85758751
101Inflammation of the large intestine (HP:0002037)1.85710533
102Abnormality of the pleura (HP:0002103)1.83173001
103Recurrent viral infections (HP:0004429)1.82661476
104Joint laxity (HP:0001388)1.82650866
105Delayed closure of the anterior fontanelle (HP:0001476)1.82562611
106Subacute progressive viral hepatitis (HP:0006572)1.82360778
107Fragile skin (HP:0001030)1.82351126
108Cone-rod dystrophy (HP:0000548)1.81607581
109Abnormality of incisor morphology (HP:0011063)1.81494883
110Abnormal rod and cone electroretinograms (HP:0008323)1.80934752
111Portal hypertension (HP:0001409)1.79514684
112Relative macrocephaly (HP:0004482)1.79418311
113Gastrointestinal inflammation (HP:0004386)1.79399680
114Infantile muscular hypotonia (HP:0008947)1.79089244
115Spinal rigidity (HP:0003306)1.78646957
116Biconcave vertebral bodies (HP:0004586)1.78046741
117Abnormality of the hepatic vasculature (HP:0006707)1.77863231
118Ankyloglossia (HP:0010296)1.76283119
119Autoimmune hemolytic anemia (HP:0001890)1.76182403
120Increased connective tissue (HP:0009025)1.75755221
121Cervical subluxation (HP:0003308)1.75424923
122Vitreoretinal degeneration (HP:0000655)1.75124850
123Type 1 muscle fiber predominance (HP:0003803)1.73716795
124Osteomyelitis (HP:0002754)1.73259417
125Stomach cancer (HP:0012126)1.73225675
126Neonatal short-limb short stature (HP:0008921)1.72618125
127Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71550844
128Dysmetric saccades (HP:0000641)1.71443361
129Abnormality of oral frenula (HP:0000190)1.71437861
130Increased IgE level (HP:0003212)1.71137510
131Abnormality of macrophages (HP:0004311)1.70793580
132Fatigue (HP:0012378)1.70649000
133Natal tooth (HP:0000695)1.70262220
134Ankle contracture (HP:0006466)1.69701234
135White forelock (HP:0002211)1.69540826
136Abnormality of T cell number (HP:0011839)1.69281968
137Distal lower limb amyotrophy (HP:0008944)1.69240496
138Abnormality of skeletal muscle fiber size (HP:0012084)1.68812375
139Increased corneal curvature (HP:0100692)1.68770629
140Keratoconus (HP:0000563)1.68770629
141Bone pain (HP:0002653)1.68101699
142Obstructive lung disease (HP:0006536)1.67740446
143Chronic obstructive pulmonary disease (HP:0006510)1.67740446
144Long eyelashes (HP:0000527)1.67737769
145Keratoconjunctivitis sicca (HP:0001097)1.67237076
146Flat acetabular roof (HP:0003180)1.67141729
147Decreased central vision (HP:0007663)1.66523762
148Ulnar bowing (HP:0003031)1.65885656
149Abnormality of the radial head (HP:0003995)1.65840773
150Increased number of teeth (HP:0011069)1.65512882
151Aortic regurgitation (HP:0001659)1.65061573
152Premature rupture of membranes (HP:0001788)1.64886171
153Leukocytosis (HP:0001974)1.64498117
154Plagiocephaly (HP:0001357)1.63625595
155Thin bony cortex (HP:0002753)1.63235231
156Clubbing of toes (HP:0100760)1.62921398
157Atrophic scars (HP:0001075)1.62018928
158Transitional cell carcinoma of the bladder (HP:0006740)1.60067377
159Vertebral arch anomaly (HP:0008438)1.59751026
160Hyperextensible skin (HP:0000974)1.58544882
161Abnormality of the thoracic spine (HP:0100711)1.58232494
162Hemoptysis (HP:0002105)1.57472349
163Abnormality of the lumbar spine (HP:0100712)1.57453514
164Cupped ribs (HP:0000887)1.56703485
165Increased IgM level (HP:0003496)1.55965739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.04090194
2BRD43.17826058
3MKNK23.03356617
4LATS12.35719024
5PDGFRA2.27427799
6MAP3K102.25789523
7NEK92.18782381
8IRAK42.18195524
9PRPF4B2.13783445
10IKBKB2.09495809
11MAP3K132.08371015
12CHUK2.08117074
13MAP2K32.07151855
14YES12.03233976
15EEF2K2.01831587
16JAK32.00998081
17MKNK11.99845058
18FGFR41.97668351
19TRIB31.90077651
20IRAK31.88198791
21PIK3CG1.85308285
22NUAK11.83308175
23IKBKE1.77310175
24CASK1.71393807
25FGFR31.64507663
26ZAK1.60462796
27TXK1.58313662
28ERN11.57222918
29MAP4K11.56810340
30ICK1.55447050
31FRK1.55083394
32JAK11.54816964
33SGK21.51195750
34PIM11.51123797
35CDK91.48188156
36TBK11.38892151
37RIPK41.35137877
38EPHA31.34945572
39EIF2AK21.33099797
40CDK121.32630831
41BMX1.32354827
42MUSK1.28919692
43BMPR21.25306390
44SGK31.22435556
45KSR21.21014629
46CDC42BPA1.20725132
47MAP3K61.19206933
48RIPK11.17823897
49SMG11.17474195
50CLK11.16600680
51TLK11.16316587
52TYK21.15262129
53PBK1.06961743
54STK31.06926666
55NLK1.06596373
56TRPM71.05343353
57MAPK71.03906074
58CSK1.03663706
59ZAP701.01188104
60TEC1.01007527
61HCK1.00113167
62TAOK31.00112760
63CDK60.98283811
64CAMK1G0.96952410
65WNK10.95103769
66MTOR0.94737869
67BLK0.94154388
68SRPK10.93328647
69MAP3K20.92178501
70STK40.92157750
71INSRR0.92029314
72PKN20.89350639
73MAP3K10.87828124
74PKN10.87670248
75EPHB10.87178926
76RPS6KA40.85242898
77PRKAA20.84557601
78AKT30.84161425
79RET0.83955766
80FES0.83902656
81ERBB30.80592662
82MARK20.80195681
83MOS0.80176903
84MAP3K30.79339028
85PAK20.79227215
86FGFR20.77502091
87MAPK110.77328048
88IRAK20.73633889
89ERBB40.73054930
90MST1R0.72870302
91ABL10.71395064
92STK100.70644969
93JAK20.69734629
94CDK40.67828905
95PDGFRB0.67067089
96MAPK120.66405186
97SGK2230.65651237
98SGK4940.65651237
99STK240.65283122
100EPHB20.65002905
101SGK10.63964474
102LATS20.63855637
103MAP3K50.63148294
104SIK10.62114261
105SIK30.61553389
106SCYL20.60731726
107EIF2AK30.59953516
108IRAK10.59021791
109HIPK20.58207994
110NEK60.57601056
111ITK0.56885438
112FER0.56745541
113PDK10.56536741
114RPS6KB20.55335158
115MYLK0.54550172
116DDR20.53965401
117KIT0.53294897
118PDPK10.53244066
119LCK0.53221627
120GRK10.52708487
121DYRK1B0.51977230
122RAF10.51490781
123MARK30.51239454
124TGFBR20.50272846
125RPS6KB10.49879835
126RPS6KA50.49711405
127PRKD20.48138624
128TTN0.48038380
129DMPK0.47738021
130PIK3CA0.47593167
131CSF1R0.45773280
132BCR0.45648256
133RPS6KL10.45203311
134RPS6KC10.45203311
135MELK0.44893998
136CAMK1D0.44779320
137PRKCQ0.44490963
138AKT10.43079546
139LYN0.42867264
140RPS6KA20.41639855
141FLT30.41393472
142BTK0.37261197
143SYK0.37260931
144MAPK100.36217927
145CDK30.35968608
146FGR0.32719554
147CAMK40.32556460
148MAP3K70.30996567
149INSR0.30264027

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.82281394
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.59145954
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.46219486
4Graft-versus-host disease_Homo sapiens_hsa053322.34860056
5Allograft rejection_Homo sapiens_hsa053302.12835367
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10991588
7Leishmaniasis_Homo sapiens_hsa051402.03356749
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91182278
9Measles_Homo sapiens_hsa051621.90972134
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85382536
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83755175
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78392420
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70874097
14TNF signaling pathway_Homo sapiens_hsa046681.69962509
15Osteoclast differentiation_Homo sapiens_hsa043801.65473583
16Toxoplasmosis_Homo sapiens_hsa051451.64499033
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.61522817
18Herpes simplex infection_Homo sapiens_hsa051681.60676534
19Malaria_Homo sapiens_hsa051441.59029870
20Small cell lung cancer_Homo sapiens_hsa052221.56980424
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.49793990
22Other glycan degradation_Homo sapiens_hsa005111.36797618
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35778786
24Tuberculosis_Homo sapiens_hsa051521.35370969
25Influenza A_Homo sapiens_hsa051641.34171125
26MicroRNAs in cancer_Homo sapiens_hsa052061.33824597
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33083962
28Autoimmune thyroid disease_Homo sapiens_hsa053201.29467655
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27268196
30Staphylococcus aureus infection_Homo sapiens_hsa051501.27096818
31Chemokine signaling pathway_Homo sapiens_hsa040621.26257785
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26134201
33Prostate cancer_Homo sapiens_hsa052151.25128542
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24368906
35Renal cell carcinoma_Homo sapiens_hsa052111.22582049
36Hepatitis B_Homo sapiens_hsa051611.20936394
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17968566
38Caffeine metabolism_Homo sapiens_hsa002321.17201780
39mTOR signaling pathway_Homo sapiens_hsa041501.12982637
40Apoptosis_Homo sapiens_hsa042101.12373399
41B cell receptor signaling pathway_Homo sapiens_hsa046621.06686966
42Legionellosis_Homo sapiens_hsa051341.06023596
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05643007
44VEGF signaling pathway_Homo sapiens_hsa043701.05099142
45Viral myocarditis_Homo sapiens_hsa054161.04987494
46Asthma_Homo sapiens_hsa053101.03868696
47Chronic myeloid leukemia_Homo sapiens_hsa052201.02788625
48Hematopoietic cell lineage_Homo sapiens_hsa046401.01606741
49Type I diabetes mellitus_Homo sapiens_hsa049401.00844103
50Bladder cancer_Homo sapiens_hsa052190.99544387
51Acute myeloid leukemia_Homo sapiens_hsa052210.98890200
52Salmonella infection_Homo sapiens_hsa051320.96853072
53Notch signaling pathway_Homo sapiens_hsa043300.94895642
54Rheumatoid arthritis_Homo sapiens_hsa053230.93287529
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.91863565
56African trypanosomiasis_Homo sapiens_hsa051430.89812590
57Thyroid cancer_Homo sapiens_hsa052160.87805259
58Pertussis_Homo sapiens_hsa051330.87727931
59GnRH signaling pathway_Homo sapiens_hsa049120.86725397
60Primary immunodeficiency_Homo sapiens_hsa053400.85895766
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.85110577
62Prolactin signaling pathway_Homo sapiens_hsa049170.84142509
63Hepatitis C_Homo sapiens_hsa051600.83888579
64Choline metabolism in cancer_Homo sapiens_hsa052310.82772217
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.81510663
66T cell receptor signaling pathway_Homo sapiens_hsa046600.81068869
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.80054088
68Amoebiasis_Homo sapiens_hsa051460.79332353
69Melanoma_Homo sapiens_hsa052180.78906447
70Adherens junction_Homo sapiens_hsa045200.78900095
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77801328
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77799225
73FoxO signaling pathway_Homo sapiens_hsa040680.77639853
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.74423084
75TGF-beta signaling pathway_Homo sapiens_hsa043500.73040360
76ECM-receptor interaction_Homo sapiens_hsa045120.71898025
77Focal adhesion_Homo sapiens_hsa045100.71574168
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71517142
79Proteoglycans in cancer_Homo sapiens_hsa052050.71074814
80Systemic lupus erythematosus_Homo sapiens_hsa053220.70888917
81Pancreatic cancer_Homo sapiens_hsa052120.70461070
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68592207
83Ovarian steroidogenesis_Homo sapiens_hsa049130.68526541
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68206283
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67264668
86Type II diabetes mellitus_Homo sapiens_hsa049300.67104599
87Insulin signaling pathway_Homo sapiens_hsa049100.66040706
88Platelet activation_Homo sapiens_hsa046110.65927595
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65516198
90Estrogen signaling pathway_Homo sapiens_hsa049150.65049581
91ErbB signaling pathway_Homo sapiens_hsa040120.63829200
92Pathways in cancer_Homo sapiens_hsa052000.62786536
93Viral carcinogenesis_Homo sapiens_hsa052030.62172375
94Shigellosis_Homo sapiens_hsa051310.61936167
95HTLV-I infection_Homo sapiens_hsa051660.61546043
96Epstein-Barr virus infection_Homo sapiens_hsa051690.58999607
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57440122
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.57074505
99Antigen processing and presentation_Homo sapiens_hsa046120.56643780
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55372872
101MAPK signaling pathway_Homo sapiens_hsa040100.54375708
102Lysine degradation_Homo sapiens_hsa003100.54169353
103Dorso-ventral axis formation_Homo sapiens_hsa043200.52447614
104p53 signaling pathway_Homo sapiens_hsa041150.52037864
105HIF-1 signaling pathway_Homo sapiens_hsa040660.51871022
106Glioma_Homo sapiens_hsa052140.51266216
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50902498
108Ras signaling pathway_Homo sapiens_hsa040140.49946155
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48441763
110Wnt signaling pathway_Homo sapiens_hsa043100.48427967
111Inositol phosphate metabolism_Homo sapiens_hsa005620.48023853
112Endometrial cancer_Homo sapiens_hsa052130.46490174
113Non-small cell lung cancer_Homo sapiens_hsa052230.44264084
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44033960
115Insulin resistance_Homo sapiens_hsa049310.42760085
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40497056
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39680236
118Basal cell carcinoma_Homo sapiens_hsa052170.38949701
119Colorectal cancer_Homo sapiens_hsa052100.38728923
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38214695

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