RIC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.74340367
2vocalization behavior (GO:0071625)5.28401221
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.27581525
4synaptic vesicle exocytosis (GO:0016079)5.22896507
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.14611138
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98167193
7synaptic vesicle maturation (GO:0016188)4.94982336
8regulation of synaptic vesicle exocytosis (GO:2000300)4.92406004
9neuron cell-cell adhesion (GO:0007158)4.90918816
10protein localization to synapse (GO:0035418)4.82036519
11glutamate secretion (GO:0014047)4.80047138
12locomotory exploration behavior (GO:0035641)4.68454191
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.65898880
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.61951679
15behavioral response to nicotine (GO:0035095)4.57913863
16regulation of glutamate receptor signaling pathway (GO:1900449)4.48921181
17neuronal action potential propagation (GO:0019227)4.45832632
18glutamate receptor signaling pathway (GO:0007215)4.44317959
19regulation of synaptic vesicle transport (GO:1902803)4.30977731
20synaptic transmission, glutamatergic (GO:0035249)4.26545502
21neurotransmitter secretion (GO:0007269)4.23845505
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15511063
23neuron-neuron synaptic transmission (GO:0007270)4.13329396
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.08696497
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.05401791
26cellular potassium ion homeostasis (GO:0030007)3.97742609
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.96713094
28exploration behavior (GO:0035640)3.90100697
29neurotransmitter-gated ion channel clustering (GO:0072578)3.89135613
30pyrimidine nucleobase catabolic process (GO:0006208)3.84129824
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83102092
32response to pheromone (GO:0019236)3.81552884
33regulation of neuronal synaptic plasticity (GO:0048168)3.80235179
34positive regulation of synapse maturation (GO:0090129)3.75211029
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71199573
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70937279
37long-term memory (GO:0007616)3.69016135
38synaptic vesicle endocytosis (GO:0048488)3.65136544
39cerebellar Purkinje cell differentiation (GO:0021702)3.64958190
40neurotransmitter transport (GO:0006836)3.64572940
41regulation of postsynaptic membrane potential (GO:0060078)3.61678752
42presynaptic membrane assembly (GO:0097105)3.60409492
43proline transport (GO:0015824)3.59730657
44positive regulation of membrane potential (GO:0045838)3.59032868
45neuron recognition (GO:0008038)3.56848875
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.56407895
47regulation of synapse structural plasticity (GO:0051823)3.55201395
48transmission of nerve impulse (GO:0019226)3.53204587
49gamma-aminobutyric acid transport (GO:0015812)3.51952638
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.51641087
51response to histamine (GO:0034776)3.49504018
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48257939
53postsynaptic membrane organization (GO:0001941)3.47379995
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46911590
55long-term synaptic potentiation (GO:0060291)3.46541314
56regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45991916
57regulation of neurotransmitter secretion (GO:0046928)3.45265239
58layer formation in cerebral cortex (GO:0021819)3.43269148
59dendritic spine morphogenesis (GO:0060997)3.42930134
60innervation (GO:0060384)3.41348962
61cerebellar granule cell differentiation (GO:0021707)3.39723209
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.38765890
63neuromuscular process controlling posture (GO:0050884)3.38658523
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.37568943
65membrane hyperpolarization (GO:0060081)3.36329269
66epithelial cilium movement (GO:0003351)3.34451826
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33350405
68presynaptic membrane organization (GO:0097090)3.32193360
69mating behavior (GO:0007617)3.32082018
70nucleobase catabolic process (GO:0046113)3.31119198
71membrane depolarization during action potential (GO:0086010)3.29292930
72synapse assembly (GO:0007416)3.28005830
73regulation of vesicle fusion (GO:0031338)3.25708940
74protein polyglutamylation (GO:0018095)3.25086609
75regulation of synaptic plasticity (GO:0048167)3.24122923
76nonmotile primary cilium assembly (GO:0035058)3.23497848
77axonal fasciculation (GO:0007413)3.23459526
78regulation of neurotransmitter levels (GO:0001505)3.22673862
79regulation of neurotransmitter transport (GO:0051588)3.22516053
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20514839
81membrane depolarization (GO:0051899)3.18345641
82regulation of synapse maturation (GO:0090128)3.15711023
83sodium ion export (GO:0071436)3.13152612
84behavioral fear response (GO:0001662)3.12871333
85behavioral defense response (GO:0002209)3.12871333
86prepulse inhibition (GO:0060134)3.11119890
87striatum development (GO:0021756)3.10467914
88axoneme assembly (GO:0035082)3.08926464
89positive regulation of neurotransmitter transport (GO:0051590)3.08216069
90response to auditory stimulus (GO:0010996)3.05095039
91fear response (GO:0042596)3.03505226
92learning (GO:0007612)3.03127975
93regulation of dendritic spine morphogenesis (GO:0061001)3.02556045
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02485720
95positive regulation of dendritic spine morphogenesis (GO:0061003)3.02056657
96* synaptic transmission (GO:0007268)3.01928568
97activation of protein kinase A activity (GO:0034199)3.00136276
98startle response (GO:0001964)3.00074684
99water-soluble vitamin biosynthetic process (GO:0042364)2.99831468
100regulation of respiratory system process (GO:0044065)2.98802615
101dendrite morphogenesis (GO:0048813)2.97951564
102adult walking behavior (GO:0007628)2.97603855
103positive regulation of neurotransmitter secretion (GO:0001956)2.97560477
104neuronal action potential (GO:0019228)2.97448911
105somite development (GO:0061053)2.97142090
106neuronal ion channel clustering (GO:0045161)2.97012546
107behavioral response to cocaine (GO:0048148)2.96385030
108neuromuscular process controlling balance (GO:0050885)2.95819797
109auditory behavior (GO:0031223)2.95691534
110positive regulation of synapse assembly (GO:0051965)2.95675404
111positive regulation of synaptic transmission (GO:0050806)2.93301181
112serotonin metabolic process (GO:0042428)2.91529558
113reflex (GO:0060004)2.90696834
114long term synaptic depression (GO:0060292)2.89490452
115protein localization to cilium (GO:0061512)2.88037610
116glycerophospholipid catabolic process (GO:0046475)2.83717910
117cilium movement (GO:0003341)2.83659643
118regulation of cilium movement (GO:0003352)2.82046137
119regulation of action potential (GO:0098900)2.81394628
120regulation of neurotransmitter uptake (GO:0051580)2.75369660
121mechanosensory behavior (GO:0007638)2.74566914
122primary amino compound metabolic process (GO:1901160)2.71769155
123retinal cone cell development (GO:0046549)2.69564616
124fucose catabolic process (GO:0019317)2.67456283
125L-fucose metabolic process (GO:0042354)2.67456283
126L-fucose catabolic process (GO:0042355)2.67456283
127positive regulation of oligodendrocyte differentiation (GO:0048714)2.64981231
128detection of light stimulus involved in sensory perception (GO:0050962)2.64170838
129detection of light stimulus involved in visual perception (GO:0050908)2.64170838
130inositol phosphate catabolic process (GO:0071545)2.63456561
131retinal ganglion cell axon guidance (GO:0031290)2.62507283
132dopamine transport (GO:0015872)2.61441681
133glycosphingolipid biosynthetic process (GO:0006688)2.61388903
134action potential (GO:0001508)2.58988074
135protein complex biogenesis (GO:0070271)2.57307287
136central nervous system myelination (GO:0022010)2.55109929
137axon ensheathment in central nervous system (GO:0032291)2.55109929
138cell proliferation in forebrain (GO:0021846)2.53428780
139photoreceptor cell development (GO:0042461)2.53348162
140neural tube formation (GO:0001841)2.52131425
141establishment of protein localization to Golgi (GO:0072600)2.52077809
142detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51188693
143cilium organization (GO:0044782)2.50141177
144multicellular organismal signaling (GO:0035637)2.50005953
145spinal cord development (GO:0021510)2.48976858
146substrate-independent telencephalic tangential migration (GO:0021826)2.47767063
147substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.47767063
148dentate gyrus development (GO:0021542)2.47037954
149regulation of calcium ion-dependent exocytosis (GO:0017158)2.46639189
150cilium assembly (GO:0042384)2.46523951
151positive regulation of potassium ion transmembrane transport (GO:1901381)2.45937740
152positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.44861286
153adaptation of signaling pathway (GO:0023058)2.44485176
154cilium morphogenesis (GO:0060271)2.44332970
155brain morphogenesis (GO:0048854)2.42985484
156photoreceptor cell maintenance (GO:0045494)2.42783853
157intraciliary transport (GO:0042073)2.42518392
158C4-dicarboxylate transport (GO:0015740)2.41024497
159indolalkylamine metabolic process (GO:0006586)2.39424297
160spinal cord motor neuron differentiation (GO:0021522)2.39269308
161neuromuscular synaptic transmission (GO:0007274)2.37902957
162neuron fate determination (GO:0048664)2.37235764
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.37166863
164NADH dehydrogenase complex assembly (GO:0010257)2.37166863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61019783
2GBX2_23144817_ChIP-Seq_PC3_Human3.99074831
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04338712
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94186588
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93489539
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.71527006
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55560234
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55560234
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54029521
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.52257503
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49390330
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47993989
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36363933
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34926031
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34174820
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.30632036
17DROSHA_22980978_ChIP-Seq_HELA_Human2.28262766
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26486740
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.17181990
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.14838409
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.14776822
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12605111
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.12047445
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12012427
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05827767
26TAF15_26573619_Chip-Seq_HEK293_Human1.99950281
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97631431
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97407934
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95528441
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87798550
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86289997
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85981330
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85112231
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.83031728
35SMAD4_21799915_ChIP-Seq_A2780_Human1.82235615
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82099765
37EWS_26573619_Chip-Seq_HEK293_Human1.71635664
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70447560
39AR_21572438_ChIP-Seq_LNCaP_Human1.67132162
40P300_19829295_ChIP-Seq_ESCs_Human1.62764056
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61562441
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59502885
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.57751607
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.56052305
45IGF1R_20145208_ChIP-Seq_DFB_Human1.51699303
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49756313
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46609240
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45260511
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44493504
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44428959
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42826382
52ZNF274_21170338_ChIP-Seq_K562_Hela1.42494022
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.40817277
54RNF2_27304074_Chip-Seq_NSC_Mouse1.39620586
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39149870
56CBP_20019798_ChIP-Seq_JUKART_Human1.39149870
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39027557
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.38668549
59STAT3_23295773_ChIP-Seq_U87_Human1.37205388
60* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37105846
61* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36124374
62AR_25329375_ChIP-Seq_VCAP_Human1.34707265
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34376815
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33513523
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31901961
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31757488
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29902377
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28645618
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27839683
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26579665
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26348838
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.25775581
73FUS_26573619_Chip-Seq_HEK293_Human1.25330735
74TCF4_23295773_ChIP-Seq_U87_Human1.22981741
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21456759
76AR_19668381_ChIP-Seq_PC3_Human1.21384584
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19999457
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19765244
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.19661372
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19302193
81TP53_22573176_ChIP-Seq_HFKS_Human1.17292007
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17100593
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16485198
84* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15913106
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15013658
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14203394
87VDR_22108803_ChIP-Seq_LS180_Human1.14150361
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14107386
89IRF1_19129219_ChIP-ChIP_H3396_Human1.13478924
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.12614825
91P53_22387025_ChIP-Seq_ESCs_Mouse1.12569264
92TCF4_22108803_ChIP-Seq_LS180_Human1.12543978
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12304590
94RUNX2_22187159_ChIP-Seq_PCA_Human1.11856819
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11562523
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.11429244
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.10594315
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.09921592
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.08811199
100SOX2_19829295_ChIP-Seq_ESCs_Human1.08523723
101NANOG_19829295_ChIP-Seq_ESCs_Human1.08523723
102ER_23166858_ChIP-Seq_MCF-7_Human1.07818304
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07279988
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.07007806
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05971754
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05628613
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05355628
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05115771
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04276184
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04255196
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04230415
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04230415
113* SMAD4_21741376_ChIP-Seq_EPCs_Human1.04042477
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.02543205
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99139809
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98747327
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.98667636
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97226939
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96787879
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96450810
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.96082388
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.94974317
123AHR_22903824_ChIP-Seq_MCF-7_Human0.94971290
124BCAT_22108803_ChIP-Seq_LS180_Human0.94666782
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92907782
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.92323271
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92040981
128JUN_21703547_ChIP-Seq_K562_Human0.91113658
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.90690098
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87693967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.39830532
2MP0003880_abnormal_central_pattern4.61216792
3MP0003635_abnormal_synaptic_transmissio3.80573877
4MP0009046_muscle_twitch3.28080471
5MP0004270_analgesia3.21605406
6MP0009745_abnormal_behavioral_response3.21180483
7MP0002063_abnormal_learning/memory/cond3.06950348
8MP0002064_seizures3.02445275
9MP0001968_abnormal_touch/_nociception2.98379157
10MP0002572_abnormal_emotion/affect_behav2.75488082
11MP0005423_abnormal_somatic_nervous2.72274280
12MP0002272_abnormal_nervous_system2.66165288
13MP0001486_abnormal_startle_reflex2.60367079
14MP0002734_abnormal_mechanical_nocicepti2.59649206
15MP0002102_abnormal_ear_morphology2.49669986
16MP0002735_abnormal_chemical_nociception2.36667383
17MP0002736_abnormal_nociception_after2.35638042
18MP0002822_catalepsy2.26290799
19MP0001501_abnormal_sleep_pattern2.21122525
20MP0002067_abnormal_sensory_capabilities2.15587696
21MP0001440_abnormal_grooming_behavior2.10483080
22MP0005551_abnormal_eye_electrophysiolog2.06599403
23MP0001984_abnormal_olfaction2.01613313
24MP0002184_abnormal_innervation1.96541042
25MP0006276_abnormal_autonomic_nervous1.95533491
26MP0002733_abnormal_thermal_nociception1.89499037
27MP0001970_abnormal_pain_threshold1.87562208
28MP0000778_abnormal_nervous_system1.85253854
29MP0005646_abnormal_pituitary_gland1.78918519
30MP0002557_abnormal_social/conspecific_i1.77259316
31MP0005386_behavior/neurological_phenoty1.77160408
32MP0004924_abnormal_behavior1.77160408
33MP0008569_lethality_at_weaning1.75227728
34MP0001188_hyperpigmentation1.72880231
35MP0003787_abnormal_imprinting1.72119072
36MP0002909_abnormal_adrenal_gland1.70382622
37MP0001502_abnormal_circadian_rhythm1.67582990
38MP0001529_abnormal_vocalization1.66358726
39MP0003646_muscle_fatigue1.58783730
40MP0005645_abnormal_hypothalamus_physiol1.58594903
41MP0006072_abnormal_retinal_apoptosis1.58204871
42MP0004811_abnormal_neuron_physiology1.56947300
43MP0002882_abnormal_neuron_morphology1.50788580
44MP0000955_abnormal_spinal_cord1.50540036
45MP0004133_heterotaxia1.47334787
46MP0009780_abnormal_chondrocyte_physiolo1.46940364
47MP0003122_maternal_imprinting1.46150916
48MP0003879_abnormal_hair_cell1.44869797
49MP0003195_calcinosis1.44191742
50MP0004858_abnormal_nervous_system1.43779615
51MP0004742_abnormal_vestibular_system1.41490817
52MP0002066_abnormal_motor_capabilities/c1.36459280
53MP0003011_delayed_dark_adaptation1.35717638
54MP0002638_abnormal_pupillary_reflex1.34870736
55MP0003329_amyloid_beta_deposits1.34205118
56MP0004142_abnormal_muscle_tone1.30571942
57MP0001905_abnormal_dopamine_level1.30137387
58MP0010386_abnormal_urinary_bladder1.30071811
59MP0004885_abnormal_endolymph1.25787468
60MP0002229_neurodegeneration1.25728315
61MP0002090_abnormal_vision1.22730565
62MP0000569_abnormal_digit_pigmentation1.22484714
63MP0005253_abnormal_eye_physiology1.21781297
64MP0003633_abnormal_nervous_system1.17991713
65MP0005379_endocrine/exocrine_gland_phen1.12662264
66MP0004145_abnormal_muscle_electrophysio1.11813735
67MP0002152_abnormal_brain_morphology1.09992149
68MP0005499_abnormal_olfactory_system1.09262983
69MP0005394_taste/olfaction_phenotype1.09262983
70MP0006292_abnormal_olfactory_placode1.07300200
71MP0002163_abnormal_gland_morphology1.05975048
72MP0002752_abnormal_somatic_nervous1.05643871
73MP0002938_white_spotting1.05137558
74MP0003631_nervous_system_phenotype1.03844503
75MP0000013_abnormal_adipose_tissue1.03063578
76MP0001963_abnormal_hearing_physiology1.01798776
77MP0000631_abnormal_neuroendocrine_gland1.01653311
78MP0003136_yellow_coat_color0.99551004
79MP0000049_abnormal_middle_ear0.98908885
80MP0000427_abnormal_hair_cycle0.95883813
81MP0008872_abnormal_physiological_respon0.93462811
82MP0003119_abnormal_digestive_system0.91360894
83MP0002069_abnormal_eating/drinking_beha0.90717604
84MP0003634_abnormal_glial_cell0.90042025
85MP0003890_abnormal_embryonic-extraembry0.89460408
86MP0002751_abnormal_autonomic_nervous0.89346275
87MP0008995_early_reproductive_senescence0.88892964
88MP0000751_myopathy0.86384567
89MP0002928_abnormal_bile_duct0.85223307
90MP0000372_irregular_coat_pigmentation0.85003075
91MP0003938_abnormal_ear_development0.84982296
92MP0002277_abnormal_respiratory_mucosa0.84458644
93MP0005084_abnormal_gallbladder_morpholo0.82983336
94MP0005174_abnormal_tail_pigmentation0.82701695
95MP0002876_abnormal_thyroid_physiology0.81911355
96MP0003632_abnormal_nervous_system0.81674016
97MP0002160_abnormal_reproductive_system0.80824572
98MP0004043_abnormal_pH_regulation0.80778525
99MP0005377_hearing/vestibular/ear_phenot0.80415347
100MP0003878_abnormal_ear_physiology0.80415347
101MP0005409_darkened_coat_color0.79756748
102MP0001485_abnormal_pinna_reflex0.79439494
103MP0005535_abnormal_body_temperature0.76326433
104MP0004215_abnormal_myocardial_fiber0.75527120
105MP0004085_abnormal_heartbeat0.75359625
106MP0004233_abnormal_muscle_weight0.74723808
107MP0002653_abnormal_ependyma_morphology0.74650844
108MP0005195_abnormal_posterior_eye0.73648951
109MP0003283_abnormal_digestive_organ0.72663492
110MP0001177_atelectasis0.71438931
111MP0002837_dystrophic_cardiac_calcinosis0.67001237
112MP0008874_decreased_physiological_sensi0.65305869
113MP0001986_abnormal_taste_sensitivity0.65120381
114MP0003121_genomic_imprinting0.64775843
115MP0000026_abnormal_inner_ear0.64008701
116MP0000920_abnormal_myelination0.63115978
117MP0001664_abnormal_digestion0.62772730
118MP0003690_abnormal_glial_cell0.60590876
119MP0003137_abnormal_impulse_conducting0.59078488
120MP0003861_abnormal_nervous_system0.57755202
121MP0001299_abnormal_eye_distance/0.57734598
122MP0008789_abnormal_olfactory_epithelium0.57701154
123MP0008877_abnormal_DNA_methylation0.55665590
124MP0005171_absent_coat_pigmentation0.55462409

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.20230113
2Myokymia (HP:0002411)5.61875882
3Focal seizures (HP:0007359)5.27774245
4Febrile seizures (HP:0002373)5.18108456
5Epileptic encephalopathy (HP:0200134)4.98740698
6Atonic seizures (HP:0010819)4.91376675
7Visual hallucinations (HP:0002367)4.71772355
8Progressive cerebellar ataxia (HP:0002073)4.57863114
9Absence seizures (HP:0002121)4.43077281
10Dialeptic seizures (HP:0011146)4.05596107
11Generalized tonic-clonic seizures (HP:0002069)3.81556604
12Pancreatic fibrosis (HP:0100732)3.74545562
13Pancreatic cysts (HP:0001737)3.68880745
14Action tremor (HP:0002345)3.57071241
15True hermaphroditism (HP:0010459)3.53330493
16Nephronophthisis (HP:0000090)3.53235100
17Gaze-evoked nystagmus (HP:0000640)3.45761689
18Broad-based gait (HP:0002136)3.44095314
19Congenital stationary night blindness (HP:0007642)3.36460448
20Hyperventilation (HP:0002883)3.33699492
21Molar tooth sign on MRI (HP:0002419)3.33114314
22Abnormality of midbrain morphology (HP:0002418)3.33114314
23Dysdiadochokinesis (HP:0002075)3.20544870
24Truncal ataxia (HP:0002078)3.16609826
25Central scotoma (HP:0000603)3.13515514
26Abnormality of the renal medulla (HP:0100957)2.94922443
27Drooling (HP:0002307)2.90172799
28Excessive salivation (HP:0003781)2.90172799
29Supranuclear gaze palsy (HP:0000605)2.89953976
30Poor eye contact (HP:0000817)2.85168174
31Methylmalonic acidemia (HP:0002912)2.84310301
32Depression (HP:0000716)2.80915448
33Abnormality of macular pigmentation (HP:0008002)2.76720667
34Dysmetria (HP:0001310)2.75481286
35Impaired vibration sensation in the lower limbs (HP:0002166)2.75331183
36Abnormal eating behavior (HP:0100738)2.72844821
37Ankle clonus (HP:0011448)2.72607364
38Gait imbalance (HP:0002141)2.71438387
39Pendular nystagmus (HP:0012043)2.67591045
40Urinary bladder sphincter dysfunction (HP:0002839)2.65435873
41Anxiety (HP:0000739)2.64374225
42Abnormality of the renal cortex (HP:0011035)2.63055576
43Hemiparesis (HP:0001269)2.63050248
44Mutism (HP:0002300)2.60264530
45Impaired smooth pursuit (HP:0007772)2.59266760
46Impaired social interactions (HP:0000735)2.57858915
47Abnormal social behavior (HP:0012433)2.57858915
48Epileptiform EEG discharges (HP:0011182)2.56322574
49Type II lissencephaly (HP:0007260)2.55613865
50Amblyopia (HP:0000646)2.55189680
51Abolished electroretinogram (ERG) (HP:0000550)2.54423187
52Limb dystonia (HP:0002451)2.53893161
53Genetic anticipation (HP:0003743)2.49684422
54Fetal akinesia sequence (HP:0001989)2.46012906
55Pheochromocytoma (HP:0002666)2.45063117
56Scanning speech (HP:0002168)2.44500664
57Absent speech (HP:0001344)2.44186974
58Congenital primary aphakia (HP:0007707)2.42524389
59EEG with generalized epileptiform discharges (HP:0011198)2.41869863
60Progressive inability to walk (HP:0002505)2.41774204
61Cystic liver disease (HP:0006706)2.41097647
62Postural instability (HP:0002172)2.39295828
63Abnormality of ocular smooth pursuit (HP:0000617)2.35341985
64Spastic gait (HP:0002064)2.33242716
65Optic nerve hypoplasia (HP:0000609)2.30091232
66Methylmalonic aciduria (HP:0012120)2.30090545
67Renal cortical cysts (HP:0000803)2.26349037
68Nephrogenic diabetes insipidus (HP:0009806)2.24769878
69Medial flaring of the eyebrow (HP:0010747)2.23728076
70Scotoma (HP:0000575)2.21324597
71Abnormality of the corticospinal tract (HP:0002492)2.21129003
72Polyphagia (HP:0002591)2.20313005
73Abnormality of binocular vision (HP:0011514)2.19836026
74Diplopia (HP:0000651)2.19836026
75Hypsarrhythmia (HP:0002521)2.16939821
76Acute necrotizing encephalopathy (HP:0006965)2.16827067
77Chronic hepatic failure (HP:0100626)2.14508990
78Abnormal respiratory epithelium morphology (HP:0012253)2.14364047
79Abnormal respiratory motile cilium morphology (HP:0005938)2.14364047
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14341007
81Insidious onset (HP:0003587)2.14041489
82Termporal pattern (HP:0011008)2.14041489
83Intestinal atresia (HP:0011100)2.13118333
84Progressive macrocephaly (HP:0004481)2.12858199
85Abnormality of the labia minora (HP:0012880)2.12122785
86Status epilepticus (HP:0002133)2.11444404
87Agitation (HP:0000713)2.11090273
88Specific learning disability (HP:0001328)2.10692165
89Neuroendocrine neoplasm (HP:0100634)2.09818094
90Lissencephaly (HP:0001339)2.08196383
91Attenuation of retinal blood vessels (HP:0007843)2.07911527
92Bradykinesia (HP:0002067)2.06692782
93Dysmetric saccades (HP:0000641)2.06387655
94Sclerocornea (HP:0000647)2.05622382
95Inability to walk (HP:0002540)2.04433005
96Abnormality of the lower motor neuron (HP:0002366)2.04022519
97Stereotypic behavior (HP:0000733)2.02650040
98Intention tremor (HP:0002080)2.01628755
99Septo-optic dysplasia (HP:0100842)2.01149444
100Genital tract atresia (HP:0001827)1.99970272
101Urinary urgency (HP:0000012)1.99366880
102Hypothermia (HP:0002045)1.99197849
103Polydipsia (HP:0001959)1.98334897
104Abnormal drinking behavior (HP:0030082)1.98334897
105Protruding tongue (HP:0010808)1.97710390
106Abnormal ciliary motility (HP:0012262)1.97425965
107Poor coordination (HP:0002370)1.97133847
108Pachygyria (HP:0001302)1.96997918
109Hemiplegia (HP:0002301)1.96996260
110Abnormality of salivation (HP:0100755)1.96618099
111Oligodactyly (hands) (HP:0001180)1.96563738
112Torticollis (HP:0000473)1.96397261
113Vaginal atresia (HP:0000148)1.95184877
114Retinal dysplasia (HP:0007973)1.93739399
115Male pseudohermaphroditism (HP:0000037)1.92351570
116Anencephaly (HP:0002323)1.92072130
117Blue irides (HP:0000635)1.91598747
118Congenital hepatic fibrosis (HP:0002612)1.90396604
119Neurofibrillary tangles (HP:0002185)1.90101730
120Generalized myoclonic seizures (HP:0002123)1.89500817
121Impaired vibratory sensation (HP:0002495)1.89140629
122Thyroid-stimulating hormone excess (HP:0002925)1.88474864
123Hyperglycinemia (HP:0002154)1.88470292
124Abnormal rod and cone electroretinograms (HP:0008323)1.88341741
125Dyschromatopsia (HP:0007641)1.88266762
126Gait ataxia (HP:0002066)1.88226208
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.87903188
128Postaxial foot polydactyly (HP:0001830)1.87858291
129Decreased central vision (HP:0007663)1.87441739
130Postaxial hand polydactyly (HP:0001162)1.87416427
131Absent/shortened dynein arms (HP:0200106)1.87199033
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.87199033
133Severe visual impairment (HP:0001141)1.87119033
134Lower limb muscle weakness (HP:0007340)1.86673271
135Incomplete penetrance (HP:0003829)1.84057607
136Increased corneal curvature (HP:0100692)1.84003134
137Keratoconus (HP:0000563)1.84003134
138Mitochondrial inheritance (HP:0001427)1.83765728
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.83722811
140Cerebral inclusion bodies (HP:0100314)1.83433713
141Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82774237
142Abnormality of vitamin B metabolism (HP:0004340)1.82293932
143Failure to thrive in infancy (HP:0001531)1.81934926
144Furrowed tongue (HP:0000221)1.81402434
145Degeneration of the lateral corticospinal tracts (HP:0002314)1.80594367
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80594367
147Hypoventilation (HP:0002791)1.79551723
148Colon cancer (HP:0003003)1.79457357
149Focal dystonia (HP:0004373)1.78930332
150Large for gestational age (HP:0001520)1.78556319
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78392582
152Acute encephalopathy (HP:0006846)1.77538966
153Horizontal nystagmus (HP:0000666)1.77214603
154Ventricular fibrillation (HP:0001663)1.76850755
155Bony spicule pigmentary retinopathy (HP:0007737)1.76622874
156Abnormal mitochondria in muscle tissue (HP:0008316)1.70613311
157Tubular atrophy (HP:0000092)1.70240312
158Hypomagnesemia (HP:0002917)1.67583996
159Dyskinesia (HP:0100660)1.67529141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.86511674
2NTRK34.55540028
3EPHA43.83776868
4MAP3K43.50516784
5CASK3.13031583
6MAP3K93.01017234
7MAP2K72.96827504
8MARK12.91249526
9MAP4K22.65710774
10MINK12.56738112
11GRK12.33860696
12PAK62.18586350
13NTRK22.08250271
14DAPK22.04277798
15PRPF4B1.94046335
16MAP2K41.91767887
17ADRBK21.88154179
18MAP3K121.87211285
19BMPR1B1.85052065
20TNIK1.81332086
21PLK21.58732250
22MAPK131.57594453
23PNCK1.56703125
24KSR21.50263325
25RIPK41.50092379
26GRK51.49187823
27CDK191.44260125
28CDK51.44071621
29KSR11.42533588
30NTRK11.41588239
31FGFR21.38170805
32DAPK11.37476299
33DYRK21.36915860
34TAOK31.36906416
35PRKD31.36742896
36CAMKK11.36408147
37STK381.34822567
38NUAK11.29845063
39CAMKK21.29619560
40PRKCG1.25722113
41WNK41.22994757
42UHMK11.21209823
43CSNK1G11.18585966
44SGK4941.13894169
45SGK2231.13894169
46CSNK1G31.12786125
47CAMK2A1.12260059
48ACVR1B1.12193686
49AKT31.11877411
50SIK21.11251336
51STK161.08357393
52TLK11.07195506
53PHKG21.06437802
54PHKG11.06437802
55ARAF1.04326481
56CAMK2B1.02668138
57TRIM281.02646164
58OXSR11.02625098
59SGK20.99178543
60FES0.98490245
61ZAK0.95635620
62MKNK20.91100626
63ERBB30.90824158
64MAP3K20.90409498
65DYRK1A0.89434858
66STK38L0.89354706
67CDK180.88067043
68TXK0.86782322
69CDK150.85088151
70CDK140.84307932
71CAMK10.84246006
72CSNK1A1L0.81955840
73PINK10.81584286
74WNK30.81121181
75STK110.81087441
76INSRR0.78838441
77BCKDK0.76700833
78CAMK2D0.76181521
79WNK10.76079191
80BMPR20.74749257
81CDK11A0.73656698
82MAPK150.73139739
83SGK10.72432645
84STK390.71654779
85CSNK1G20.70849689
86PAK30.70388633
87MAP3K130.69709233
88SIK30.69500819
89TYRO30.68941434
90NEK60.67353461
91PRKCH0.66970678
92SGK30.65631498
93PRKCE0.64401734
94PKN10.63308998
95BCR0.61999193
96MAP3K60.61960809
97BRAF0.60984840
98TNK20.60842333
99LATS20.60602135
100IRAK20.60409690
101NME10.60180049
102RET0.59136280
103ALK0.57212400
104CAMK1G0.56188355
105CAMK2G0.55967546
106PTK2B0.55853342
107MARK20.55423991
108FER0.55273845
109CDK30.54835507
110CCNB10.54828966
111CSNK1A10.54174853
112GRK70.53297921
113MAPK100.50115927
114MAP2K60.49987396
115RPS6KA30.49313770
116EPHA30.47769164
117OBSCN0.46604202
118ADRBK10.46305598
119TIE10.46247814
120CDC42BPA0.44266471
121PRKAA10.44239384
122CSNK1D0.43920783
123PRKCZ0.43783937
124MAP3K10.42116741
125FGR0.41743803
126RAF10.40984463
127PRKG10.40411807
128ERBB20.40364456
129PDK10.40277978
130VRK10.40163503
131TAOK10.39603743
132PRKACA0.39410292
133DYRK30.38759359
134CAMK40.38737996
135PDPK10.38219186
136PRKCB0.37878614
137PRKCA0.37057059
138PRKCQ0.36091777
139PIK3CA0.34251122
140PRKACB0.31400259
141RPS6KA50.31315771
142TEC0.30595447
143RPS6KB10.30411821
144CSNK1E0.29684756

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.31437379
2Synaptic vesicle cycle_Homo sapiens_hsa047213.49804570
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94400485
4GABAergic synapse_Homo sapiens_hsa047272.91687339
5Morphine addiction_Homo sapiens_hsa050322.70600982
6Circadian entrainment_Homo sapiens_hsa047132.68960982
7Olfactory transduction_Homo sapiens_hsa047402.65166411
8Glutamatergic synapse_Homo sapiens_hsa047242.64804062
9Long-term potentiation_Homo sapiens_hsa047202.49827729
10Amphetamine addiction_Homo sapiens_hsa050312.44187302
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.41217935
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25978652
13Dopaminergic synapse_Homo sapiens_hsa047282.19870676
14Insulin secretion_Homo sapiens_hsa049112.18893348
15Phototransduction_Homo sapiens_hsa047442.13308153
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13082532
17Taste transduction_Homo sapiens_hsa047422.11296178
18Salivary secretion_Homo sapiens_hsa049702.11169061
19Butanoate metabolism_Homo sapiens_hsa006502.08661431
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01021637
21Serotonergic synapse_Homo sapiens_hsa047261.90145027
22Cholinergic synapse_Homo sapiens_hsa047251.88419860
23Collecting duct acid secretion_Homo sapiens_hsa049661.82234860
24Protein export_Homo sapiens_hsa030601.79559201
25Long-term depression_Homo sapiens_hsa047301.76000827
26Cocaine addiction_Homo sapiens_hsa050301.74017124
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73955489
28Renin secretion_Homo sapiens_hsa049241.72065525
29Gastric acid secretion_Homo sapiens_hsa049711.68511544
30Parkinsons disease_Homo sapiens_hsa050121.68459216
31Linoleic acid metabolism_Homo sapiens_hsa005911.61748581
32Calcium signaling pathway_Homo sapiens_hsa040201.58398003
33Oxytocin signaling pathway_Homo sapiens_hsa049211.54109134
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53606846
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47602301
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37091699
37Ether lipid metabolism_Homo sapiens_hsa005651.34662346
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34425713
39GnRH signaling pathway_Homo sapiens_hsa049121.33654248
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29243029
41cAMP signaling pathway_Homo sapiens_hsa040241.27443803
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27278049
43Type II diabetes mellitus_Homo sapiens_hsa049301.26708493
44Gap junction_Homo sapiens_hsa045401.24037093
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23826812
46Basal transcription factors_Homo sapiens_hsa030221.23426527
47Regulation of autophagy_Homo sapiens_hsa041401.21382830
48Nitrogen metabolism_Homo sapiens_hsa009101.20373691
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18733547
50Vibrio cholerae infection_Homo sapiens_hsa051101.17642395
51Propanoate metabolism_Homo sapiens_hsa006401.15252065
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09380855
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07787721
54Cardiac muscle contraction_Homo sapiens_hsa042601.07506102
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06407375
56Huntingtons disease_Homo sapiens_hsa050161.06118541
57Axon guidance_Homo sapiens_hsa043601.05989178
58Tryptophan metabolism_Homo sapiens_hsa003801.04732071
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03270687
60RNA degradation_Homo sapiens_hsa030181.00385099
61Estrogen signaling pathway_Homo sapiens_hsa049151.00284363
62RNA polymerase_Homo sapiens_hsa030200.93746425
63ErbB signaling pathway_Homo sapiens_hsa040120.92250562
64Peroxisome_Homo sapiens_hsa041460.90628914
65Pancreatic secretion_Homo sapiens_hsa049720.89703149
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.89414906
67Melanogenesis_Homo sapiens_hsa049160.86112466
68beta-Alanine metabolism_Homo sapiens_hsa004100.84916771
69Glioma_Homo sapiens_hsa052140.83576541
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83163408
71Fanconi anemia pathway_Homo sapiens_hsa034600.82996566
72Selenocompound metabolism_Homo sapiens_hsa004500.82677723
73Caffeine metabolism_Homo sapiens_hsa002320.81515657
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80024689
75Retinol metabolism_Homo sapiens_hsa008300.78547059
76Oocyte meiosis_Homo sapiens_hsa041140.78521445
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.76394879
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76261574
79Thyroid hormone synthesis_Homo sapiens_hsa049180.75202183
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.74913983
81Circadian rhythm_Homo sapiens_hsa047100.74321632
82Dorso-ventral axis formation_Homo sapiens_hsa043200.72625159
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71757515
84Chemical carcinogenesis_Homo sapiens_hsa052040.70121469
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70084575
86Choline metabolism in cancer_Homo sapiens_hsa052310.68968739
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68401070
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.68376179
89Dilated cardiomyopathy_Homo sapiens_hsa054140.67259652
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67004308
91ABC transporters_Homo sapiens_hsa020100.65782759
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65546392
93MAPK signaling pathway_Homo sapiens_hsa040100.65323014
94Homologous recombination_Homo sapiens_hsa034400.62383551
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58967326
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58620783
97Inositol phosphate metabolism_Homo sapiens_hsa005620.58566438
98Alcoholism_Homo sapiens_hsa050340.57916405
99Hedgehog signaling pathway_Homo sapiens_hsa043400.57519654
100Type I diabetes mellitus_Homo sapiens_hsa049400.56213091
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55326365
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53641704
103Ras signaling pathway_Homo sapiens_hsa040140.53596215
104Glucagon signaling pathway_Homo sapiens_hsa049220.53368909
105Alzheimers disease_Homo sapiens_hsa050100.52641981
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52559454
107Glycerolipid metabolism_Homo sapiens_hsa005610.51144801
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50646876
109Ovarian steroidogenesis_Homo sapiens_hsa049130.49706274
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46224525
111Oxidative phosphorylation_Homo sapiens_hsa001900.44865346
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44721067
113Arachidonic acid metabolism_Homo sapiens_hsa005900.43360101
114Rap1 signaling pathway_Homo sapiens_hsa040150.42010096
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.41996617
116Basal cell carcinoma_Homo sapiens_hsa052170.41994491
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41305114
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.40204219
119Metabolic pathways_Homo sapiens_hsa011000.39855046
120mTOR signaling pathway_Homo sapiens_hsa041500.39733137
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39634786
122Wnt signaling pathway_Homo sapiens_hsa043100.39244683
123Histidine metabolism_Homo sapiens_hsa003400.38797700
124Renal cell carcinoma_Homo sapiens_hsa052110.37959543
125Purine metabolism_Homo sapiens_hsa002300.37363997
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37059695
127Fat digestion and absorption_Homo sapiens_hsa049750.35510726
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34756145
129VEGF signaling pathway_Homo sapiens_hsa043700.34556511
130Rheumatoid arthritis_Homo sapiens_hsa053230.33902788
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.32686012
132Steroid biosynthesis_Homo sapiens_hsa001000.32421711
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32377090
134Prion diseases_Homo sapiens_hsa050200.31335206
135Vitamin digestion and absorption_Homo sapiens_hsa049770.30724540
136Insulin signaling pathway_Homo sapiens_hsa049100.30183720
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30063148
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29943180
139Endometrial cancer_Homo sapiens_hsa052130.29590153
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29380942
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28590477
142Endocytosis_Homo sapiens_hsa041440.28068267
143Bile secretion_Homo sapiens_hsa049760.27992504
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24721929
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24338171
146Non-small cell lung cancer_Homo sapiens_hsa052230.24302194
147Mineral absorption_Homo sapiens_hsa049780.24214400

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