RIC8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.83176610
2COPI coating of Golgi vesicle (GO:0048205)5.83176610
3positive regulation of gamma-delta T cell activation (GO:0046645)5.72673586
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.58305807
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.58305807
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36751101
7antigen processing and presentation of endogenous antigen (GO:0019883)4.94581129
8antigen processing and presentation via MHC class Ib (GO:0002475)4.82615424
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.77354154
10protein localization to endosome (GO:0036010)4.51739348
11regulation of B cell receptor signaling pathway (GO:0050855)4.41866553
12actin filament depolymerization (GO:0030042)4.35113241
13positive regulation of B cell differentiation (GO:0045579)4.23977581
14protein retention in ER lumen (GO:0006621)4.18666422
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.12637919
16negative regulation of cell killing (GO:0031342)3.95940871
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95940871
18regulation of interleukin-12 biosynthetic process (GO:0045075)3.92558026
19platelet dense granule organization (GO:0060155)3.91602449
20Arp2/3 complex-mediated actin nucleation (GO:0034314)3.90049966
21regulation of B cell differentiation (GO:0045577)3.88722920
22B cell receptor signaling pathway (GO:0050853)3.86823791
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.80028315
24regulation of gamma-delta T cell differentiation (GO:0045586)3.79413347
25hemidesmosome assembly (GO:0031581)3.78289632
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.78205441
27ribosomal small subunit assembly (GO:0000028)3.75832226
28mast cell activation (GO:0045576)3.74928360
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.74809558
30negative regulation of erythrocyte differentiation (GO:0045647)3.72538326
31skin morphogenesis (GO:0043589)3.70286232
32cell-substrate junction assembly (GO:0007044)3.67793744
33defense response to protozoan (GO:0042832)3.63306433
34regulation of gamma-delta T cell activation (GO:0046643)3.62623550
35response to protozoan (GO:0001562)3.59913529
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.59332980
37leukocyte aggregation (GO:0070486)3.59152160
38protein maturation by protein folding (GO:0022417)3.53718610
39negative regulation of phagocytosis (GO:0050765)3.50952118
40stress fiber assembly (GO:0043149)3.50869346
41response to type I interferon (GO:0034340)3.45591957
42type I interferon signaling pathway (GO:0060337)3.45553988
43cellular response to type I interferon (GO:0071357)3.45553988
44definitive hemopoiesis (GO:0060216)3.41942184
45regulation of early endosome to late endosome transport (GO:2000641)3.41292356
46focal adhesion assembly (GO:0048041)3.38828369
47cell-substrate adherens junction assembly (GO:0007045)3.38828369
48T cell homeostasis (GO:0043029)3.36116307
49regulation of defense response to virus by virus (GO:0050690)3.35945015
50endosome to melanosome transport (GO:0035646)3.32898471
51endosome to pigment granule transport (GO:0043485)3.32898471
52response to interleukin-15 (GO:0070672)3.30252400
53positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.30064294
54mitotic nuclear envelope reassembly (GO:0007084)3.29946879
55nuclear envelope reassembly (GO:0031468)3.29946879
56adherens junction assembly (GO:0034333)3.29543634
57regulation of natural killer cell differentiation (GO:0032823)3.28451535
58mature B cell differentiation involved in immune response (GO:0002313)3.27569336
59positive regulation of macrophage differentiation (GO:0045651)3.20209538
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.19969622
61immunoglobulin mediated immune response (GO:0016064)3.17457512
62DNA deamination (GO:0045006)3.17084362
63proline biosynthetic process (GO:0006561)3.16194479
64interferon-gamma-mediated signaling pathway (GO:0060333)3.15726334
65cell adhesion mediated by integrin (GO:0033627)3.15368817
66interferon-gamma production (GO:0032609)3.15311590
67NIK/NF-kappaB signaling (GO:0038061)3.13156754
68mature B cell differentiation (GO:0002335)3.12258872
69megakaryocyte development (GO:0035855)3.11410370
70pinocytosis (GO:0006907)3.11015858
71positive regulation of blood vessel endothelial cell migration (GO:0043536)3.10908026
72neutrophil activation involved in immune response (GO:0002283)3.09442149
73myeloid dendritic cell activation (GO:0001773)3.09213528
74response to interferon-beta (GO:0035456)3.06269350
75mannose metabolic process (GO:0006013)3.05803671
76negative regulation of cell size (GO:0045792)3.05262361
77viral transcription (GO:0019083)3.03718920
78tolerance induction (GO:0002507)3.03127101
79regulation of T cell receptor signaling pathway (GO:0050856)3.01992486
80apoptotic process involved in morphogenesis (GO:0060561)3.01381747
81regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98030229
82endodermal cell differentiation (GO:0035987)2.95940036
83detection of other organism (GO:0098543)2.95607575
84adhesion of symbiont to host (GO:0044406)2.94852137
85adhesion of symbiont to host cell (GO:0044650)2.94584344
86virion attachment to host cell (GO:0019062)2.94584344
87actin nucleation (GO:0045010)2.91958674
88erythrocyte maturation (GO:0043249)2.91369475
89positive regulation of natural killer cell differentiation (GO:0032825)2.91042871
90lymph node development (GO:0048535)2.90247476
91myeloid dendritic cell differentiation (GO:0043011)2.87867193
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.87694342
93response to interferon-alpha (GO:0035455)2.87565170
94antigen receptor-mediated signaling pathway (GO:0050851)2.86585029
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85437713
96cellular response to interleukin-15 (GO:0071350)2.83033530
97detection of bacterium (GO:0016045)2.82451544
98regulation of T cell mediated cytotoxicity (GO:0001914)2.81437299
99regulation of glucose import in response to insulin stimulus (GO:2001273)2.80451768
100JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.80428545
101cellular response to virus (GO:0098586)2.79611612
102negative T cell selection (GO:0043383)2.79203893
103regulation of interferon-beta biosynthetic process (GO:0045357)2.78654462
104macrophage differentiation (GO:0030225)2.77891822
105negative regulation of fatty acid transport (GO:2000192)2.76977642
106lymphocyte homeostasis (GO:0002260)2.76967699
107positive thymic T cell selection (GO:0045059)2.76528295
108lymphoid progenitor cell differentiation (GO:0002320)2.74603981
109positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74146066
110mast cell degranulation (GO:0043303)2.73697025
111mast cell activation involved in immune response (GO:0002279)2.73697025
112neutrophil activation (GO:0042119)2.73553543
113epithelial cell-cell adhesion (GO:0090136)2.73206373
114negative thymic T cell selection (GO:0045060)2.72664117
115histamine secretion (GO:0001821)2.72582169
116natural killer cell differentiation (GO:0001779)2.72294498
117positive regulation of Cdc42 GTPase activity (GO:0043089)2.71873229
118leukocyte homeostasis (GO:0001776)2.71513880
119translational termination (GO:0006415)2.71284150
120positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.70365412
121barbed-end actin filament capping (GO:0051016)2.69920375
1223-UTR-mediated mRNA stabilization (GO:0070935)2.68699029
123cellular extravasation (GO:0045123)2.67939880
124regulation of isotype switching to IgG isotypes (GO:0048302)2.67849459
125hypotonic response (GO:0006971)2.67275275
126regulation of protein heterodimerization activity (GO:0043497)2.67032310
127protein carboxylation (GO:0018214)2.66223647
128peptidyl-glutamic acid carboxylation (GO:0017187)2.66223647
129regulation of regulatory T cell differentiation (GO:0045589)2.64347607
130positive regulation of isotype switching (GO:0045830)2.64289761
131angiogenesis involved in wound healing (GO:0060055)2.64167913
132negative regulation of B cell apoptotic process (GO:0002903)2.63859349
133positive regulation of granulocyte differentiation (GO:0030854)2.63600954
134activation of Rac GTPase activity (GO:0032863)2.62806062
135cellular zinc ion homeostasis (GO:0006882)2.62050182
136UV protection (GO:0009650)2.61681979
137type B pancreatic cell proliferation (GO:0044342)2.61221336
138regulation of natural killer cell activation (GO:0032814)2.61185938
139SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60654165
140activation of MAPKKK activity (GO:0000185)2.60495741
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60478004
142positive regulation of extracellular matrix organization (GO:1903055)2.59953142
143activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59775474
144modulation by symbiont of host cellular process (GO:0044068)2.59504166
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58369235
146leukocyte cell-cell adhesion (GO:0007159)2.57867042
147regulation of B cell apoptotic process (GO:0002902)2.57672987
148endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.57597418
149* basement membrane organization (GO:0071711)2.56659358
150fibril organization (GO:0097435)2.55142319
151regulation of leukocyte mediated cytotoxicity (GO:0001910)2.54362043
152vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54092661
153negative regulation of interleukin-17 production (GO:0032700)2.54060576
154pentose-phosphate shunt (GO:0006098)2.53543453
155regulation of natural killer cell mediated immunity (GO:0002715)2.53195089
156regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.53195089
157embryonic process involved in female pregnancy (GO:0060136)2.53126765
158regulation of apoptotic process involved in morphogenesis (GO:1902337)2.52943707
159cotranslational protein targeting to membrane (GO:0006613)2.52248952
160protein targeting to ER (GO:0045047)2.52217297
161leukocyte degranulation (GO:0043299)2.51877496
162myeloid cell activation involved in immune response (GO:0002275)2.50603215
163B cell mediated immunity (GO:0019724)2.50528644
164endoplasmic reticulum unfolded protein response (GO:0030968)2.49881233
165regulation of extracellular matrix disassembly (GO:0010715)2.48668979
166semaphorin-plexin signaling pathway (GO:0071526)2.48124235
167positive regulation of nuclease activity (GO:0032075)2.48030771
168cytoskeletal anchoring at plasma membrane (GO:0007016)2.48023339
169membrane raft organization (GO:0031579)2.47163060
170cortical actin cytoskeleton organization (GO:0030866)2.45874483
171positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.45519179
172apoptotic cell clearance (GO:0043277)2.44912416
173regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44827480
174spliceosomal tri-snRNP complex assembly (GO:0000244)2.43772756
175peptidyl-proline hydroxylation (GO:0019511)2.43186167
176positive regulation of endothelial cell apoptotic process (GO:2000353)2.43032059
177extracellular fibril organization (GO:0043206)2.42418684
178vesicle coating (GO:0006901)2.41548772
179positive regulation of receptor recycling (GO:0001921)2.39520732
180protein targeting to plasma membrane (GO:0072661)2.39278215
181vascular endothelial growth factor signaling pathway (GO:0038084)2.37735151
182modulation by virus of host morphology or physiology (GO:0019048)2.37175957
183amyloid precursor protein catabolic process (GO:0042987)2.37013239
184positive regulation of osteoblast proliferation (GO:0033690)2.35704777
185response to laminar fluid shear stress (GO:0034616)2.35672768
186membrane protein ectodomain proteolysis (GO:0006509)2.35461088
187retrograde transport, endosome to Golgi (GO:0042147)2.34825740
188hyaluronan catabolic process (GO:0030214)2.33847845
189negative regulation of skeletal muscle tissue development (GO:0048642)2.33588809
190venous blood vessel morphogenesis (GO:0048845)2.32250486
191regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30956205
192protein hydroxylation (GO:0018126)2.30655147
193negative regulation of protein localization to plasma membrane (GO:1903077)2.28792961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.28612117
2MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.02794275
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.92025505
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.89926657
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.74232204
6SCL_19346495_ChIP-Seq_HPC-7_Human3.58452947
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.54409293
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.52132255
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.47527025
10VDR_21846776_ChIP-Seq_THP-1_Human3.13476060
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.08930165
12MYC_22102868_ChIP-Seq_BL_Human3.00066675
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.97142222
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.81745462
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.76436394
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64400649
17VDR_24763502_ChIP-Seq_THP-1_Human2.63095698
18* MAF_26560356_Chip-Seq_TH1_Human2.58344323
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.56199995
20MYB_26560356_Chip-Seq_TH2_Human2.55778058
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.49429157
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48934800
23RUNX_20019798_ChIP-Seq_JUKART_Human2.48211845
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40928990
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37464360
26* SPI1_23547873_ChIP-Seq_NB4_Human2.35693182
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28960113
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.27834704
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.24857420
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.24802604
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.17451328
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.16759160
33EGR1_19374776_ChIP-ChIP_THP-1_Human2.10893664
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10548833
35* UTX_26944678_Chip-Seq_JUKART_Human2.09979818
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08832610
37* RACK7_27058665_Chip-Seq_MCF-7_Human2.04578366
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03009081
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00909083
40MYB_26560356_Chip-Seq_TH1_Human1.97394145
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.94458925
42TCF7_22412390_ChIP-Seq_EML_Mouse1.92642446
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.92217688
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86388534
45SPI1_23127762_ChIP-Seq_K562_Human1.86309288
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81493922
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81109733
48ZNF263_19887448_ChIP-Seq_K562_Human1.79768737
49* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78843696
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78464540
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77633137
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74448665
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73897523
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72808879
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71220059
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70161386
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69391653
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61434111
59CLOCK_20551151_ChIP-Seq_293T_Human1.60085118
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57774798
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57686756
62MAF_26560356_Chip-Seq_TH2_Human1.57443613
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56606144
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56559696
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55541348
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.55165015
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53473363
68KDM2B_26808549_Chip-Seq_DND41_Human1.52402434
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50744960
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.50211540
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50086766
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49102141
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48418063
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.48217622
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47243659
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.47074804
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46993840
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46222712
79* LXR_22292898_ChIP-Seq_THP-1_Human1.46015613
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42693515
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41706535
82ATF3_27146783_Chip-Seq_COLON_Human1.41688018
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39604703
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39216183
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.39162089
86TRIM28_21343339_ChIP-Seq_HEK293_Human1.37662951
87KDM2B_26808549_Chip-Seq_K562_Human1.36014366
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35615933
89P68_20966046_ChIP-Seq_HELA_Human1.33328819
90TP53_22127205_ChIP-Seq_IMR90_Human1.33031252
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32824201
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32151039
93GATA3_27048872_Chip-Seq_THYMUS_Human1.31239322
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30491319
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28659308
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27231742
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26582003
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26033444
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.25502817
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25324744
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25214574
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23522605
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22942527
104GATA1_22025678_ChIP-Seq_K562_Human1.22395852
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.21568574
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20081393
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19840394
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18477658
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18336958
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18262769
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.17685115
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17087644
113PU_27001747_Chip-Seq_BMDM_Mouse1.16911234
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16505314
115ESR2_21235772_ChIP-Seq_MCF-7_Human1.16407638
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15351037
117BCL6_27268052_Chip-Seq_Bcells_Human1.14373968
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13071788
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13044351
120SMC4_20622854_ChIP-Seq_HELA_Human1.12153466
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11606808
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09772372
123SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.08983625
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07475633
125GATA1_19941826_ChIP-Seq_K562_Human1.07203157
126BCOR_27268052_Chip-Seq_Bcells_Human1.07150767
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06331617
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05682787
129CIITA_25753668_ChIP-Seq_RAJI_Human1.05589152
130CREB1_26743006_Chip-Seq_LNCaP_Human1.05342756
131ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03491931
132SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01122558
133FOXM1_23109430_ChIP-Seq_U2OS_Human1.01112510
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99847968
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99828850
136RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99483486
137GATA3_26560356_Chip-Seq_TH2_Human0.98970609
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98842740
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98805416
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98358145
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98302622
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98280430
143ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96886814
144GATA2_19941826_ChIP-Seq_K562_Human0.95720240
145PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95674509
146PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93671461
147FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91396654
148SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89815984
149CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89703356
150VDR_24787735_ChIP-Seq_THP-1_Human0.89533634
151FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89282733
152RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88173359
153EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87397193
154TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85946887
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.84868919
156PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83595893
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83595653
158NCOR1_26117541_ChIP-Seq_K562_Human0.83112929
159RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82848710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.75100988
2MP0008438_abnormal_cutaneous_collagen4.34770807
3MP0001835_abnormal_antigen_presentation3.51157407
4MP0000685_abnormal_immune_system3.39087081
5MP0003436_decreased_susceptibility_to3.06945548
6MP0009785_altered_susceptibility_to2.95030122
7MP0005671_abnormal_response_to2.83683145
8MP0003724_increased_susceptibility_to2.81472441
9MP0003763_abnormal_thymus_physiology2.76739330
10MP0001790_abnormal_immune_system2.74573802
11MP0005387_immune_system_phenotype2.74573802
12MP0005000_abnormal_immune_tolerance2.73048321
13MP0001800_abnormal_humoral_immune2.66349046
14MP0002396_abnormal_hematopoietic_system2.62275814
15MP0002148_abnormal_hypersensitivity_rea2.56348397
16MP0005025_abnormal_response_to2.55997338
17MP0002452_abnormal_antigen_presenting2.55682063
18MP0002420_abnormal_adaptive_immunity2.55034055
19MP0002723_abnormal_immune_serum2.54296165
20MP0003303_peritoneal_inflammation2.51310421
21MP0001819_abnormal_immune_cell2.51209041
22MP0005451_abnormal_body_composition2.40924656
23MP0005174_abnormal_tail_pigmentation2.39690908
24MP0005464_abnormal_platelet_physiology2.38971074
25MP0002419_abnormal_innate_immunity2.37951843
26MP0009840_abnormal_foam_cell2.37047512
27MP0004272_abnormal_basement_membrane2.31303955
28MP0002166_altered_tumor_susceptibility2.28875197
29MP0003091_abnormal_cell_migration2.27895504
30MP0002398_abnormal_bone_marrow2.25639896
31MP0005257_abnormal_intraocular_pressure2.20342443
32MP0002405_respiratory_system_inflammati2.16315070
33MP0004808_abnormal_hematopoietic_stem2.14822597
34MP0001958_emphysema2.12850514
35MP0003191_abnormal_cellular_cholesterol2.03651282
36MP0003866_abnormal_defecation2.03406797
37MP0000716_abnormal_immune_system2.02943818
38MP0000465_gastrointestinal_hemorrhage2.02066777
39MP0001849_ear_inflammation1.99128215
40MP0005023_abnormal_wound_healing1.91281507
41MP0005397_hematopoietic_system_phenotyp1.91248518
42MP0001545_abnormal_hematopoietic_system1.91248518
43MP0001986_abnormal_taste_sensitivity1.87582809
44MP0010155_abnormal_intestine_physiology1.85893270
45MP0000689_abnormal_spleen_morphology1.81592252
46MP0010234_abnormal_vibrissa_follicle1.79185309
47MP0002722_abnormal_immune_system1.78428864
48MP0002429_abnormal_blood_cell1.77450243
49MP0001873_stomach_inflammation1.77228620
50MP0000015_abnormal_ear_pigmentation1.69270629
51MP0005623_abnormal_meninges_morphology1.68941031
52MP0003300_gastrointestinal_ulcer1.68163803
53MP0001845_abnormal_inflammatory_respons1.67956958
54MP0002006_tumorigenesis1.66649318
55MP0002060_abnormal_skin_morphology1.66533575
56MP0009333_abnormal_splenocyte_physiolog1.64506745
57MP0005275_abnormal_skin_tensile1.61650680
58MP0002095_abnormal_skin_pigmentation1.61508900
59MP0003453_abnormal_keratinocyte_physiol1.59767489
60MP0000703_abnormal_thymus_morphology1.58483616
61MP0001542_abnormal_bone_strength1.55525444
62MP0002933_joint_inflammation1.55509960
63MP0001533_abnormal_skeleton_physiology1.53514536
64MP0003172_abnormal_lysosome_physiology1.50680473
65MP0004185_abnormal_adipocyte_glucose1.48715789
66MP0010368_abnormal_lymphatic_system1.46486424
67MP0001348_abnormal_lacrimal_gland1.45983282
68MP0005075_abnormal_melanosome_morpholog1.40905372
69MP0009379_abnormal_foot_pigmentation1.39090773
70MP0005076_abnormal_cell_differentiation1.37922522
71MP0009278_abnormal_bone_marrow1.36157273
72MP0000490_abnormal_crypts_of1.35926564
73MP0000751_myopathy1.34727239
74MP0005310_abnormal_salivary_gland1.32384443
75MP0010352_gastrointestinal_tract_polyps1.31872334
76MP0000767_abnormal_smooth_muscle1.29273956
77MP0002132_abnormal_respiratory_system1.27644025
78MP0005058_abnormal_lysosome_morphology1.26477818
79MP0009053_abnormal_anal_canal1.26090029
80MP0002796_impaired_skin_barrier1.25605012
81MP0003329_amyloid_beta_deposits1.25221340
82MP0005501_abnormal_skin_physiology1.24842149
83MP0004947_skin_inflammation1.23581652
84MP0000372_irregular_coat_pigmentation1.22452422
85MP0000733_abnormal_muscle_development1.22432237
86MP0008469_abnormal_protein_level1.21230004
87MP0009384_cardiac_valve_regurgitation1.20644435
88MP0001243_abnormal_dermal_layer1.19490796
89MP0002009_preneoplasia1.19077401
90MP0000003_abnormal_adipose_tissue1.14855307
91MP0003183_abnormal_peptide_metabolism1.14759905
92MP0001853_heart_inflammation1.14570456
93MP0004233_abnormal_muscle_weight1.14279640
94MP0003950_abnormal_plasma_membrane1.13885145
95MP0000858_altered_metastatic_potential1.11046356
96MP0004270_analgesia1.10765570
97MP0004510_myositis1.10704403
98MP0002735_abnormal_chemical_nociception1.06961360
99MP0005503_abnormal_tendon_morphology1.06233272
100MP0006082_CNS_inflammation1.06219755
101MP0000569_abnormal_digit_pigmentation1.05126455
102MP0005166_decreased_susceptibility_to1.04681484
103MP0003279_aneurysm1.04576404
104MP0005621_abnormal_cell_physiology1.04102122
105MP0000750_abnormal_muscle_regeneration1.01940663
106MP0008260_abnormal_autophagy0.99484552
107MP0003075_altered_response_to0.96621145
108MP0010030_abnormal_orbit_morphology0.96519077
109MP0001216_abnormal_epidermal_layer0.95129876
110MP0005508_abnormal_skeleton_morphology0.94994592
111MP0002896_abnormal_bone_mineralization0.93873581
112MP0000747_muscle_weakness0.93227408
113MP0001661_extended_life_span0.90828302
114MP0002998_abnormal_bone_remodeling0.89945938
115MP0000343_altered_response_to0.87284265
116MP0009764_decreased_sensitivity_to0.86732537
117MP0000537_abnormal_urethra_morphology0.86439416
118MP0005408_hypopigmentation0.85742022
119MP0003448_altered_tumor_morphology0.85598146
120MP0000013_abnormal_adipose_tissue0.83954661
121MP0000604_amyloidosis0.83548558
122MP0001851_eye_inflammation0.83375952
123MP0000759_abnormal_skeletal_muscle0.83312682
124MP0001915_intracranial_hemorrhage0.83095865
125MP0000681_abnormal_thyroid_gland0.82107559
126MP0001663_abnormal_digestive_system0.81190170
127MP0000678_abnormal_parathyroid_gland0.80471893
128MP0005375_adipose_tissue_phenotype0.77510189
129MP0000762_abnormal_tongue_morphology0.77204150
130MP0005165_increased_susceptibility_to0.76620114
131MP0000467_abnormal_esophagus_morphology0.76542785
132MP0006054_spinal_hemorrhage0.76541197
133MP0005197_abnormal_uvea_morphology0.75180230
134MP0005409_darkened_coat_color0.73535796
135MP0005390_skeleton_phenotype0.73352142
136MP0000371_diluted_coat_color0.71942986
137MP0003566_abnormal_cell_adhesion0.71637891
138MP0000249_abnormal_blood_vessel0.71271992
139MP0001730_embryonic_growth_arrest0.71200916
140MP0009931_abnormal_skin_appearance0.70939765
141MP0004883_abnormal_blood_vessel0.69259937
142MP0001968_abnormal_touch/_nociception0.68503932
143MP0002877_abnormal_melanocyte_morpholog0.67787605
144MP0003656_abnormal_erythrocyte_physiolo0.67143030
145MP0005384_cellular_phenotype0.67071610
146MP0002019_abnormal_tumor_incidence0.66799115
147MP0002075_abnormal_coat/hair_pigmentati0.66305440
148MP0004858_abnormal_nervous_system0.66272839
149MP0008007_abnormal_cellular_replicative0.66209965
150MP0004147_increased_porphyrin_level0.66078138
151MP0001614_abnormal_blood_vessel0.65324366
152MP0010771_integument_phenotype0.64008131
153MP0003943_abnormal_hepatobiliary_system0.63336117
154MP0006276_abnormal_autonomic_nervous0.61562411
155MP0005164_abnormal_response_to0.60122767
156MP0002089_abnormal_postnatal_growth/wei0.58825482
157MP0009765_abnormal_xenobiotic_induced0.58694564
158MP0008873_increased_physiological_sensi0.58250903
159MP0003795_abnormal_bone_structure0.57177645
160MP0003828_pulmonary_edema0.53715835

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.48772953
2Myositis (HP:0100614)5.02840643
3Protrusio acetabuli (HP:0003179)4.77780347
4Elevated erythrocyte sedimentation rate (HP:0003565)4.61472430
5Recurrent abscess formation (HP:0002722)4.58039637
6Thrombocytosis (HP:0001894)4.27268455
7Spontaneous hematomas (HP:0007420)4.07382284
8Recurrent bacterial skin infections (HP:0005406)4.07301102
9Chronic otitis media (HP:0000389)3.95425424
10Eczematoid dermatitis (HP:0000976)3.74971922
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.62092760
12Mutism (HP:0002300)3.42651234
13IgM deficiency (HP:0002850)3.29486889
14Gastrointestinal inflammation (HP:0004386)3.28143442
15Prolonged bleeding time (HP:0003010)3.27882913
16Thin bony cortex (HP:0002753)3.27490234
17Abnormality of the nasal mucosa (HP:0000433)3.25287281
18Cellulitis (HP:0100658)3.24569428
19Inflammation of the large intestine (HP:0002037)3.22538146
20Atrophic scars (HP:0001075)3.17444130
21Abnormality of macrophages (HP:0004311)3.16491514
22Increased IgE level (HP:0003212)3.14081668
23Meningitis (HP:0001287)3.13959878
24Panhypogammaglobulinemia (HP:0003139)3.12577746
25Petechiae (HP:0000967)3.12194767
26Recurrent fungal infections (HP:0002841)3.11337298
27Recurrent viral infections (HP:0004429)3.10548284
28Hyperacusis (HP:0010780)3.09818446
29Cervical subluxation (HP:0003308)3.05679989
30Agammaglobulinemia (HP:0004432)2.99547753
31Interstitial pulmonary disease (HP:0006530)2.99082930
32Ankle contracture (HP:0006466)2.94058274
33Nasal polyposis (HP:0100582)2.93540831
34Epistaxis (HP:0000421)2.93216403
35Achilles tendon contracture (HP:0001771)2.92441603
36Fragile skin (HP:0001030)2.90946686
37Fatigue (HP:0012378)2.90352377
38Recurrent skin infections (HP:0001581)2.88925091
39Vacuolated lymphocytes (HP:0001922)2.88437400
40Short nail (HP:0001799)2.87396978
41Recurrent bronchitis (HP:0002837)2.82896465
42Spinal rigidity (HP:0003306)2.82821563
43Obstructive lung disease (HP:0006536)2.80601845
44Chronic obstructive pulmonary disease (HP:0006510)2.80601845
45Long foot (HP:0001833)2.78480729
46Orchitis (HP:0100796)2.75104927
47Broad face (HP:0000283)2.69226735
48Vasculitis (HP:0002633)2.67214177
49B lymphocytopenia (HP:0010976)2.67070912
50Abnormality of B cell number (HP:0010975)2.67070912
51Aortic dissection (HP:0002647)2.64122173
52Neoplasm of the adrenal cortex (HP:0100641)2.60863833
53Increased connective tissue (HP:0009025)2.60305808
54Ulnar bowing (HP:0003031)2.59645243
55Abnormality of the Achilles tendon (HP:0005109)2.59583021
56Aplastic anemia (HP:0001915)2.59329893
57Chest pain (HP:0100749)2.58021189
58Bladder diverticulum (HP:0000015)2.56621959
59Elbow flexion contracture (HP:0002987)2.56206958
60Distal lower limb amyotrophy (HP:0008944)2.56016570
61Mediastinal lymphadenopathy (HP:0100721)2.54213141
62Abnormality of T cells (HP:0002843)2.51399991
63Wormian bones (HP:0002645)2.51053998
64Abnormality of T cell physiology (HP:0011840)2.50596256
65Vertebral compression fractures (HP:0002953)2.50360129
66Upper limb amyotrophy (HP:0009129)2.50000219
67Distal upper limb amyotrophy (HP:0007149)2.50000219
68Blue sclerae (HP:0000592)2.48715960
69Colitis (HP:0002583)2.48587525
70Vascular tortuosity (HP:0004948)2.48292383
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.47296906
72Chronic mucocutaneous candidiasis (HP:0002728)2.45842551
73Recurrent cutaneous fungal infections (HP:0011370)2.45842551
74Mitral regurgitation (HP:0001653)2.45631474
75Increased cerebral lipofuscin (HP:0011813)2.45500106
76Dilatation of the ascending aorta (HP:0005111)2.43088886
77Aortic aneurysm (HP:0004942)2.42503380
78Cerebral aneurysm (HP:0004944)2.41516159
79Retrobulbar optic neuritis (HP:0100654)2.40771491
80Optic neuritis (HP:0100653)2.40771491
81Stomatitis (HP:0010280)2.39848493
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.37060175
83Osteolytic defects of the hand bones (HP:0009699)2.37060175
84Arterial tortuosity (HP:0005116)2.36199902
85Long palpebral fissure (HP:0000637)2.35660220
86Gingival bleeding (HP:0000225)2.34165335
87Bowed forearm bones (HP:0003956)2.33527788
88Bowing of the arm (HP:0006488)2.33527788
89Increased density of long bones (HP:0006392)2.33263554
90Centrally nucleated skeletal muscle fibers (HP:0003687)2.33061811
91Abnormality of the distal phalanges of the toes (HP:0010182)2.30931950
92Hypergammaglobulinemia (HP:0010702)2.29141644
93T lymphocytopenia (HP:0005403)2.26899452
94Biconcave vertebral bodies (HP:0004586)2.25736408
95Purpura (HP:0000979)2.24209180
96Arterial thrombosis (HP:0004420)2.24018648
97Increased variability in muscle fiber diameter (HP:0003557)2.22811152
98Pustule (HP:0200039)2.22420870
99Chronic sinusitis (HP:0011109)2.20867678
100Shallow orbits (HP:0000586)2.20490635
101Periodontitis (HP:0000704)2.19562992
102Abnormality of T cell number (HP:0011839)2.17849418
103Disproportionate tall stature (HP:0001519)2.17696798
104Hemoptysis (HP:0002105)2.17374562
105Reticulocytopenia (HP:0001896)2.15780460
106Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15512331
107Genu recurvatum (HP:0002816)2.14901289
108Abnormal platelet function (HP:0011869)2.12602351
109Impaired platelet aggregation (HP:0003540)2.12602351
110Distal lower limb muscle weakness (HP:0009053)2.12093332
111Pulmonary infiltrates (HP:0002113)2.11672276
112Back pain (HP:0003418)2.11342760
113Natal tooth (HP:0000695)2.09429248
114Radial bowing (HP:0002986)2.09129569
115Episodic fever (HP:0001954)2.08944370
116Difficulty climbing stairs (HP:0003551)2.08130730
117Albinism (HP:0001022)2.06087587
118Neonatal hypoglycemia (HP:0001998)2.05909132
119Osteomyelitis (HP:0002754)2.05845857
120Emphysema (HP:0002097)2.04688500
121Peritonitis (HP:0002586)2.03979348
122Spondylolisthesis (HP:0003302)2.03907019
123Abnormality of the peritoneum (HP:0002585)2.03559262
124Generalized amyotrophy (HP:0003700)2.03293761
125Gastrointestinal stroma tumor (HP:0100723)2.02609523
126Hypothermia (HP:0002045)2.02532388
127Acute myeloid leukemia (HP:0004808)2.02532342
128Abnormality of skeletal muscle fiber size (HP:0012084)2.02138315
129Mildly elevated creatine phosphokinase (HP:0008180)2.01477729
130Insomnia (HP:0100785)2.01367482
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99727680
132Abnormal protein N-linked glycosylation (HP:0012347)1.99727680
133Abnormal protein glycosylation (HP:0012346)1.99727680
134Abnormal glycosylation (HP:0012345)1.99727680
135Abnormal platelet volume (HP:0011876)1.99362099
136Aneurysm (HP:0002617)1.99113919
137Dysostosis multiplex (HP:0000943)1.98063338
138Abnormality of dentin (HP:0010299)1.97656298
139Lymphopenia (HP:0001888)1.97170073
140Abnormality of skull ossification (HP:0002703)1.94942437
141Stridor (HP:0010307)1.94891236
142Hand muscle atrophy (HP:0009130)1.94091084
143Erythema (HP:0010783)1.93160506
144Joint laxity (HP:0001388)1.92915022
145Abnormality of cells of the lymphoid lineage (HP:0012140)1.92268215
146Encephalitis (HP:0002383)1.91524439
147Joint stiffness (HP:0001387)1.90185409
148Hematochezia (HP:0002573)1.90057765
149Type I transferrin isoform profile (HP:0003642)1.89065118
150Abnormal pancreas size (HP:0012094)1.88733140
151Long toe (HP:0010511)1.86034257
152Amaurosis fugax (HP:0100576)1.85984653
153Abnormality of the acetabulum (HP:0003170)1.85808073
154Flat acetabular roof (HP:0003180)1.85560065
155Aplasia/Hypoplasia of the clavicles (HP:0006710)1.84299322
156Urticaria (HP:0001025)1.84047867
157Growth hormone excess (HP:0000845)1.83252168
158Femoral bowing (HP:0002980)1.82580657
159Soft skin (HP:0000977)1.82219438
160Abnormal number of erythroid precursors (HP:0012131)1.81170330
161Bruising susceptibility (HP:0000978)1.81140363
162Hyperextensible skin (HP:0000974)1.80086342
163Pallor (HP:0000980)1.79564748
164Cupped ribs (HP:0000887)1.79132632
165Sepsis (HP:0100806)1.76508968
166Poor head control (HP:0002421)1.75828069
167Abnormality of cells of the erythroid lineage (HP:0012130)1.75557573
168Ragged-red muscle fibers (HP:0003200)1.74250863
169Mitral valve prolapse (HP:0001634)1.73399173
170Coxa vara (HP:0002812)1.71068640
171Spinal cord lesions (HP:0100561)1.69333722
172Syringomyelia (HP:0003396)1.69333722
173Lower limb amyotrophy (HP:0007210)1.69305214
174Aortic regurgitation (HP:0001659)1.68603656
175Reduced subcutaneous adipose tissue (HP:0003758)1.68188530
176Trismus (HP:0000211)1.66953272
177Premature skin wrinkling (HP:0100678)1.66882840
178Abnormal ossification of hand bones (HP:0005921)1.66663284
179Abnormality of glycosphingolipid metabolism (HP:0004343)1.65901855
180Abnormality of glycolipid metabolism (HP:0010969)1.65901855
181Abnormality of liposaccharide metabolism (HP:0010968)1.65901855
182Abnormality of oral frenula (HP:0000190)1.64984715
183Entropion (HP:0000621)1.63842394
184Cerebral inclusion bodies (HP:0100314)1.62623279
185Axonal loss (HP:0003447)1.62025639
186Abnormality of the thoracic spine (HP:0100711)1.62003070
187Persistence of primary teeth (HP:0006335)1.61818221
188Thin skin (HP:0000963)1.61806705
189Type 1 muscle fiber predominance (HP:0003803)1.61490782
190Tibial bowing (HP:0002982)1.61412992
191Follicular hyperkeratosis (HP:0007502)1.61086540
192Nonimmune hydrops fetalis (HP:0001790)1.60760020
193Hemorrhage of the eye (HP:0011885)1.60111939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.51191393
2MAP3K122.99249107
3TESK22.95260095
4PRPF4B2.86382091
5STK162.84168113
6EEF2K2.81105168
7ARAF2.60462613
8SMG12.57032229
9BLK2.51968606
10KIT2.34540667
11PRKG22.23935061
12ICK2.20414762
13SIK12.19820671
14ZAP702.17926524
15BTK2.11815607
16EPHA22.11476541
17TBK12.10389833
18TTN2.07525551
19ERN12.05327566
20IRAK41.99806735
21FLT31.91153217
22PDGFRA1.89898697
23TXK1.89691096
24TEC1.87892987
25JAK31.79368701
26MOS1.73582802
27CLK11.69907580
28ITK1.68765325
29MATK1.68683078
30PIM21.67721971
31IRAK31.64953912
32RIPK41.60343407
33SYK1.59200612
34MAPKAPK31.58505098
35TGFBR21.57408509
36KSR21.54903854
37CSF1R1.48233815
38FES1.47519044
39RIPK11.45559639
40NME21.43948133
41PTK21.42378736
42IKBKE1.41047127
43TYK21.34907407
44LCK1.26199261
45MAP3K111.25732243
46CDK121.25230589
47GRK61.24434650
48LIMK11.24245966
49NLK1.23407154
50CAMKK21.21642922
51HCK1.21272783
52MAPK111.19072836
53PRKD21.18343799
54EPHA31.18201061
55MAP2K31.16671783
56NTRK11.16183640
57TGFBR11.15493944
58MST1R1.14142884
59TRIB31.13109328
60EPHB11.10863667
61BRAF1.10150467
62CDK191.08016797
63LYN1.07262431
64MAP3K91.06111633
65MAP3K131.05925201
66LRRK21.03566607
67LMTK21.00964365
68JAK10.99358592
69MAP3K140.99342125
70MAP3K60.98592447
71FGFR40.97401503
72IKBKB0.97282362
73MAP3K100.95781512
74SIK20.94940159
75SIK30.94437717
76BMX0.94082366
77IRAK10.92656763
78MAP3K80.91851517
79CSK0.89204625
80MYLK0.88695911
81STK100.88266029
82NEK90.88220433
83EPHB20.87371037
84CDC42BPA0.84567849
85MTOR0.83886962
86MET0.83622741
87TLK10.82390941
88DAPK10.82205032
89MAPKAPK50.81657765
90RPS6KB20.81506480
91PAK20.78220812
92MARK20.77258852
93TNK20.74292438
94RPS6KA20.73132669
95PDPK10.73097408
96KDR0.72923754
97STK380.72048086
98HIPK20.71195829
99DDR20.70300137
100LATS20.70104205
101TAOK10.69437172
102RAF10.68282293
103PKN20.68214157
104ALK0.67917707
105PIM10.67201175
106MAPK40.65764143
107TNIK0.65446013
108SCYL20.65013146
109CDK40.64169412
110MAP3K70.61829219
111PDGFRB0.61819870
112MAP3K30.60780884
113CDK80.59693046
114TRPM70.58434856
115PAK40.57920720
116TAOK30.57066105
117ERBB40.54036991
118PAK10.53658094
119JAK20.53198756
120RET0.51738130
121PRKD30.50701972
122CAMK10.49357735
123DAPK30.48032542
124BCKDK0.46592351
125MAPK120.46574888
126AURKA0.46303304
127RPS6KC10.45480409
128RPS6KL10.45480409
129MAP2K60.43969342
130MAP3K10.43949280
131CSNK1G30.43825719
132IRAK20.43714244
133ILK0.43695782
134MAP2K20.43648936
135RPS6KA60.42972606
136TESK10.42663657
137TIE10.41996466
138ABL20.41785702
139PTK60.41609323
140TAOK20.40837535
141MAPKAPK20.40751857
142MARK30.40700545
143PAK60.39513422
144FYN0.38412936
145CDK70.38161091
146DYRK1B0.37626261
147KSR10.37534878
148MAPK130.37411418
149FGFR30.35485442
150PDK10.34574533

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.73361637
2B cell receptor signaling pathway_Homo sapiens_hsa046622.48154995
3Leishmaniasis_Homo sapiens_hsa051402.31788936
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11688375
5Bladder cancer_Homo sapiens_hsa052192.07211686
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06982438
7Osteoclast differentiation_Homo sapiens_hsa043801.93953420
8Measles_Homo sapiens_hsa051621.88540337
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.87584802
10Prion diseases_Homo sapiens_hsa050201.82819079
11Ribosome_Homo sapiens_hsa030101.76200871
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75998343
13Central carbon metabolism in cancer_Homo sapiens_hsa052301.74856357
14Hematopoietic cell lineage_Homo sapiens_hsa046401.72557873
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.72177886
16Focal adhesion_Homo sapiens_hsa045101.72151113
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72051227
18Shigellosis_Homo sapiens_hsa051311.71182979
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.70021006
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.69757205
21Antigen processing and presentation_Homo sapiens_hsa046121.59043009
22T cell receptor signaling pathway_Homo sapiens_hsa046601.57527690
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57236158
24ECM-receptor interaction_Homo sapiens_hsa045121.55245912
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54873265
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48995432
27Platelet activation_Homo sapiens_hsa046111.47629506
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46184332
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45496407
30Small cell lung cancer_Homo sapiens_hsa052221.44078264
31Pertussis_Homo sapiens_hsa051331.42180458
32Other glycan degradation_Homo sapiens_hsa005111.41398707
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40613717
34Acute myeloid leukemia_Homo sapiens_hsa052211.40351130
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35444697
36Pentose phosphate pathway_Homo sapiens_hsa000301.35432881
37Proteoglycans in cancer_Homo sapiens_hsa052051.33987546
38Chemokine signaling pathway_Homo sapiens_hsa040621.32503126
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32163910
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30872700
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29476149
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28451197
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.27703835
44Apoptosis_Homo sapiens_hsa042101.27613117
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27546490
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.27197501
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.26909550
48Toxoplasmosis_Homo sapiens_hsa051451.24743414
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24550035
50Fructose and mannose metabolism_Homo sapiens_hsa000511.24062553
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21595484
52Salmonella infection_Homo sapiens_hsa051321.19785286
53Galactose metabolism_Homo sapiens_hsa000521.19660558
54N-Glycan biosynthesis_Homo sapiens_hsa005101.18478925
55Chronic myeloid leukemia_Homo sapiens_hsa052201.13523212
56Tuberculosis_Homo sapiens_hsa051521.12413447
57Influenza A_Homo sapiens_hsa051641.10769388
58Glioma_Homo sapiens_hsa052141.10617907
59Endometrial cancer_Homo sapiens_hsa052131.09790131
60Biosynthesis of amino acids_Homo sapiens_hsa012301.07602689
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05082459
62Renal cell carcinoma_Homo sapiens_hsa052111.04912484
63Malaria_Homo sapiens_hsa051441.03952291
64Hepatitis C_Homo sapiens_hsa051601.03949198
65Hepatitis B_Homo sapiens_hsa051611.03846765
66African trypanosomiasis_Homo sapiens_hsa051431.03172595
67Lysosome_Homo sapiens_hsa041421.01862889
68Allograft rejection_Homo sapiens_hsa053301.00585988
69Legionellosis_Homo sapiens_hsa051340.99649306
70Herpes simplex infection_Homo sapiens_hsa051680.98193825
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96612172
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95969009
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95489805
74Sulfur relay system_Homo sapiens_hsa041220.93600748
75TNF signaling pathway_Homo sapiens_hsa046680.92839914
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92460975
77Phagosome_Homo sapiens_hsa041450.91924434
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.89831858
79DNA replication_Homo sapiens_hsa030300.88210776
80Rheumatoid arthritis_Homo sapiens_hsa053230.87890804
81Prolactin signaling pathway_Homo sapiens_hsa049170.86834807
82VEGF signaling pathway_Homo sapiens_hsa043700.86093380
83ErbB signaling pathway_Homo sapiens_hsa040120.84769820
84MicroRNAs in cancer_Homo sapiens_hsa052060.84469975
85Viral myocarditis_Homo sapiens_hsa054160.83068673
86Insulin signaling pathway_Homo sapiens_hsa049100.80636954
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79704575
88Epstein-Barr virus infection_Homo sapiens_hsa051690.79457233
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78196703
90Pancreatic cancer_Homo sapiens_hsa052120.75005185
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.74918656
92Non-small cell lung cancer_Homo sapiens_hsa052230.74396460
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73599642
94Prostate cancer_Homo sapiens_hsa052150.73263765
95Protein export_Homo sapiens_hsa030600.72565856
96Endocytosis_Homo sapiens_hsa041440.70828782
97mTOR signaling pathway_Homo sapiens_hsa041500.70422230
98Base excision repair_Homo sapiens_hsa034100.67343946
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66464783
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66188864
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65743599
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.64625088
103Adherens junction_Homo sapiens_hsa045200.62235882
104HIF-1 signaling pathway_Homo sapiens_hsa040660.62085265
105Colorectal cancer_Homo sapiens_hsa052100.61751705
106GnRH signaling pathway_Homo sapiens_hsa049120.60761224
107AMPK signaling pathway_Homo sapiens_hsa041520.60427628
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59937679
109Choline metabolism in cancer_Homo sapiens_hsa052310.59456361
110Graft-versus-host disease_Homo sapiens_hsa053320.59444104
111Pathways in cancer_Homo sapiens_hsa052000.58962883
112Asthma_Homo sapiens_hsa053100.53746620
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53139954
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.53094098
115Thyroid cancer_Homo sapiens_hsa052160.53030766
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.52272057
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51812463
118Estrogen signaling pathway_Homo sapiens_hsa049150.51110901
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51064959
120Insulin resistance_Homo sapiens_hsa049310.51005334
121Mismatch repair_Homo sapiens_hsa034300.50140932
122Viral carcinogenesis_Homo sapiens_hsa052030.49087019
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49079527
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48137466
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46394003
126Vibrio cholerae infection_Homo sapiens_hsa051100.45785918
127HTLV-I infection_Homo sapiens_hsa051660.42198203
128Renin-angiotensin system_Homo sapiens_hsa046140.41301704
129Staphylococcus aureus infection_Homo sapiens_hsa051500.38755461
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38402334
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38164517
132Cholinergic synapse_Homo sapiens_hsa047250.37845780
133Amoebiasis_Homo sapiens_hsa051460.37741521
134Inositol phosphate metabolism_Homo sapiens_hsa005620.37432126
135Notch signaling pathway_Homo sapiens_hsa043300.36738303
136Rap1 signaling pathway_Homo sapiens_hsa040150.36139670
137Caffeine metabolism_Homo sapiens_hsa002320.33925859
138Type I diabetes mellitus_Homo sapiens_hsa049400.33435642
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32600841

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