RIC8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)9.00559841
2negative regulation of fibroblast apoptotic process (GO:2000270)5.53849849
3positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.40520016
4behavioral response to nicotine (GO:0035095)5.32793585
5sensory perception of chemical stimulus (GO:0007606)5.31409750
6neurotransmitter-gated ion channel clustering (GO:0072578)4.90662134
7adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.74147972
8protein neddylation (GO:0045116)4.73488462
9protein-cofactor linkage (GO:0018065)4.62707094
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.54609730
11activation of protein kinase A activity (GO:0034199)4.44812271
12negative regulation of cytosolic calcium ion concentration (GO:0051481)4.42493232
13regulation of synapse structural plasticity (GO:0051823)4.33277595
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31663975
15synaptic vesicle maturation (GO:0016188)4.30817804
16regulation of fibroblast apoptotic process (GO:2000269)4.28449618
17pyrimidine nucleobase catabolic process (GO:0006208)4.27403359
18gamma-aminobutyric acid transport (GO:0015812)4.17147155
19presynaptic membrane assembly (GO:0097105)4.13041345
20presynaptic membrane organization (GO:0097090)4.11894709
21cell proliferation in forebrain (GO:0021846)4.01192145
22dopamine receptor signaling pathway (GO:0007212)4.00247324
23auditory behavior (GO:0031223)3.97054685
24regulation of synaptic vesicle exocytosis (GO:2000300)3.95184994
25detection of calcium ion (GO:0005513)3.92514051
26postsynaptic membrane organization (GO:0001941)3.90882610
27synaptic vesicle exocytosis (GO:0016079)3.87822309
28striatum development (GO:0021756)3.85886983
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81309408
30behavioral response to cocaine (GO:0048148)3.78512717
31protein localization to cilium (GO:0061512)3.71539895
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.66818499
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.64650409
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.53965293
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53738139
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.51941637
37regulation of synaptic vesicle transport (GO:1902803)3.50252228
38positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.49668407
39glutamate secretion (GO:0014047)3.48884532
40transmission of nerve impulse (GO:0019226)3.45151459
41prepulse inhibition (GO:0060134)3.40471200
42neuron cell-cell adhesion (GO:0007158)3.40121033
43regulation of glutamate receptor signaling pathway (GO:1900449)3.37276576
44locomotory exploration behavior (GO:0035641)3.34656109
45response to auditory stimulus (GO:0010996)3.33361657
46nucleobase catabolic process (GO:0046113)3.31924740
47layer formation in cerebral cortex (GO:0021819)3.29855862
48axonal fasciculation (GO:0007413)3.29023695
49regulation of rhodopsin mediated signaling pathway (GO:0022400)3.28898623
50tongue development (GO:0043586)3.24094868
51protein insertion into membrane (GO:0051205)3.21012270
52cerebral cortex radially oriented cell migration (GO:0021799)3.20355425
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19338327
54cellular potassium ion homeostasis (GO:0030007)3.19066963
55vocalization behavior (GO:0071625)3.18861460
56cerebellar Purkinje cell differentiation (GO:0021702)3.16371641
57rhodopsin mediated signaling pathway (GO:0016056)3.14791564
58neurotransmitter secretion (GO:0007269)3.14658232
59cAMP biosynthetic process (GO:0006171)3.13962848
60regulation of voltage-gated calcium channel activity (GO:1901385)3.13179039
61regulation of membrane repolarization (GO:0060306)3.12541456
62positive regulation of neurotransmitter transport (GO:0051590)3.09314059
63response to amphetamine (GO:0001975)3.09089748
64dendritic spine morphogenesis (GO:0060997)3.07273021
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05018238
66cellular response to glucagon stimulus (GO:0071377)3.04466437
67dendrite morphogenesis (GO:0048813)3.04051833
68mechanosensory behavior (GO:0007638)3.03790902
69retinal ganglion cell axon guidance (GO:0031290)3.03549134
70neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.03005012
71regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02179788
72chemosensory behavior (GO:0007635)3.01028719
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00475622
74synaptic transmission, dopaminergic (GO:0001963)2.99853326
75neuron recognition (GO:0008038)2.99363864
76somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97994910
77somatic hypermutation of immunoglobulin genes (GO:0016446)2.97994910
78cell communication by electrical coupling (GO:0010644)2.97820769
79mating behavior (GO:0007617)2.96374192
80regulation of neuronal synaptic plasticity (GO:0048168)2.94332119
81membrane hyperpolarization (GO:0060081)2.94212900
82membrane depolarization during action potential (GO:0086010)2.93751051
83protein localization to synapse (GO:0035418)2.92199155
84nonmotile primary cilium assembly (GO:0035058)2.90414164
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90305264
86synaptic transmission, glutamatergic (GO:0035249)2.89290348
87membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87473828
88negative regulation of microtubule polymerization (GO:0031115)2.86033397
89regulation of synaptic transmission, dopaminergic (GO:0032225)2.86006206
90vesicle transport along microtubule (GO:0047496)2.85977406
91forebrain neuron differentiation (GO:0021879)2.84880004
92response to pheromone (GO:0019236)2.84646568
93regulation of protein kinase A signaling (GO:0010738)2.83995544
94regulation of female receptivity (GO:0045924)2.83526042
95regulation of sodium ion transmembrane transporter activity (GO:2000649)2.81982914
96regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.81704141
97regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.81704141
98potassium ion homeostasis (GO:0055075)2.80485006
99positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80405409
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80068158
101replication fork processing (GO:0031297)2.79967346
102neuronal action potential (GO:0019228)2.78851327
103negative regulation of osteoblast proliferation (GO:0033689)2.78465990
104positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.78451966
105behavioral response to ethanol (GO:0048149)2.77573272
106synapse assembly (GO:0007416)2.76988505
107photoreceptor cell maintenance (GO:0045494)2.76161495
108regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74818048
109somite development (GO:0061053)2.73960331
110regulation of neurotransmitter secretion (GO:0046928)2.73746601
111regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73717993
112regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.73198909
113female mating behavior (GO:0060180)2.70847124
114neuronal action potential propagation (GO:0019227)2.70538244
115otic vesicle formation (GO:0030916)2.69332550
116regulation of calcium ion transmembrane transport (GO:1903169)2.69230795
117regulation of calcium ion transmembrane transporter activity (GO:1901019)2.69230795
118cellular potassium ion transport (GO:0071804)2.68141545
119potassium ion transmembrane transport (GO:0071805)2.68141545
120negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.67029350
121negative regulation of calcium ion transmembrane transport (GO:1903170)2.67029350
122substrate-independent telencephalic tangential migration (GO:0021826)2.66317063
123substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.66317063
124negative regulation of cation channel activity (GO:2001258)2.66251642
125regulation of heart rate by cardiac conduction (GO:0086091)2.66009261
126regulation of neurotransmitter transport (GO:0051588)2.64554366
127cAMP metabolic process (GO:0046058)2.63084395
128protein polyglutamylation (GO:0018095)2.63004872
129cell migration in hindbrain (GO:0021535)2.62776889
130positive regulation of potassium ion transmembrane transport (GO:1901381)2.62677356
131tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62668807
132RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62668807
133cardiac conduction (GO:0061337)2.61105783
134detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60990180
135regulation of meiosis I (GO:0060631)2.60578153
136cerebellum development (GO:0021549)2.59970546
137negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59349260
138behavioral fear response (GO:0001662)2.56768099
139behavioral defense response (GO:0002209)2.56768099
140cell communication involved in cardiac conduction (GO:0086065)2.56048794
141serotonin metabolic process (GO:0042428)2.55857614
142chaperone-mediated protein transport (GO:0072321)2.52555995
143adult walking behavior (GO:0007628)2.52501416
144negative regulation of oligodendrocyte differentiation (GO:0048715)2.50894859
145regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50259811
146neuronal stem cell maintenance (GO:0097150)2.49967890
147neuromuscular synaptic transmission (GO:0007274)2.49885538
148parturition (GO:0007567)2.49099700
149photoreceptor cell development (GO:0042461)2.49065245
150startle response (GO:0001964)2.47986847
151olfactory bulb development (GO:0021772)2.47679056
152regulation of action potential (GO:0098900)2.46586211
153fear response (GO:0042596)2.45736298
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45215409
155neuron-neuron synaptic transmission (GO:0007270)2.44343871
156primary amino compound metabolic process (GO:1901160)2.43668677
157central nervous system myelination (GO:0022010)2.43351255
158axon ensheathment in central nervous system (GO:0032291)2.43351255
159retinal rod cell development (GO:0046548)2.42670590
160neurofilament cytoskeleton organization (GO:0060052)2.42583161
161positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42375045
162positive regulation of action potential (GO:0045760)2.42291264
163positive regulation of cardiac muscle cell differentiation (GO:2000727)2.42169822
164ionotropic glutamate receptor signaling pathway (GO:0035235)2.41396668
165intraciliary transport (GO:0042073)2.41315338
166epithelial cilium movement (GO:0003351)2.41295916
167positive regulation of synapse assembly (GO:0051965)2.41046882
168negative regulation of astrocyte differentiation (GO:0048712)2.40737328
169L-serine metabolic process (GO:0006563)2.40290728
170cochlea development (GO:0090102)2.40246160
171head development (GO:0060322)2.39052011
172negative regulation of appetite (GO:0032099)2.38793387
173negative regulation of response to food (GO:0032096)2.38793387
174regulation of collateral sprouting (GO:0048670)2.37839626
175regulation of cilium movement (GO:0003352)2.37527564
176C4-dicarboxylate transport (GO:0015740)2.37265812
177axoneme assembly (GO:0035082)2.34696366
178limb bud formation (GO:0060174)2.32716462
179regulation of posttranscriptional gene silencing (GO:0060147)2.30886153
180regulation of gene silencing by miRNA (GO:0060964)2.30886153
181regulation of gene silencing by RNA (GO:0060966)2.30886153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.48579693
2GBX2_23144817_ChIP-Seq_PC3_Human3.44512635
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14357156
4DROSHA_22980978_ChIP-Seq_HELA_Human2.72857729
5* RARB_27405468_Chip-Seq_BRAIN_Mouse2.72790328
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62191019
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53497695
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48717309
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38424433
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38053453
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38053453
12REST_21632747_ChIP-Seq_MESCs_Mouse2.36090384
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33929089
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18802449
15FUS_26573619_Chip-Seq_HEK293_Human2.14970090
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13775769
17VDR_22108803_ChIP-Seq_LS180_Human2.12221529
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11477490
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.09899777
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06504139
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06085922
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05893416
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03420652
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00276895
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98685053
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.97289987
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.95347606
28EWS_26573619_Chip-Seq_HEK293_Human1.92356465
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.90777426
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.90670313
31TAF15_26573619_Chip-Seq_HEK293_Human1.89877596
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.88810078
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82267667
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76473776
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63326545
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59103781
37IRF1_19129219_ChIP-ChIP_H3396_Human1.58492975
38* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57049594
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55514799
40KDM2B_26808549_Chip-Seq_K562_Human1.51891741
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51844770
42SMAD4_21799915_ChIP-Seq_A2780_Human1.50058270
43ER_23166858_ChIP-Seq_MCF-7_Human1.49596644
44CBP_20019798_ChIP-Seq_JUKART_Human1.49350081
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49350081
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48917011
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48689315
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46564585
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44715631
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42580950
51ZNF263_19887448_ChIP-Seq_K562_Human1.40563477
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39559879
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.39485835
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37990078
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36160321
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36118954
57AHR_22903824_ChIP-Seq_MCF-7_Human1.33289164
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.32179579
59AR_25329375_ChIP-Seq_VCAP_Human1.31823131
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.30739678
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.30188346
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30159573
63* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29345569
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28488933
65P300_19829295_ChIP-Seq_ESCs_Human1.27632061
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27082224
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26454528
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26146832
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.26140903
70* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25709849
71* AR_19668381_ChIP-Seq_PC3_Human1.25537476
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.25454433
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25149323
74* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24756496
75ZNF274_21170338_ChIP-Seq_K562_Hela1.24498052
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.24359313
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23496013
78* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22341580
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22069016
80* STAT3_23295773_ChIP-Seq_U87_Human1.21718586
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21485688
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20239185
83AR_21572438_ChIP-Seq_LNCaP_Human1.19037516
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17684963
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16713139
86* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16643860
87RNF2_27304074_Chip-Seq_NSC_Mouse1.16640278
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16395480
89* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15267860
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.15010408
91* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14337604
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13096713
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13035745
94* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12318767
95* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11875761
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11303234
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10937642
98SMAD4_21741376_ChIP-Seq_HESCs_Human1.10818196
99* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09663400
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09051497
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08335439
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.08223823
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07337017
104TCF4_22108803_ChIP-Seq_LS180_Human1.07189026
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07148518
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.06019867
107TP53_22573176_ChIP-Seq_HFKS_Human1.05444481
108* FLI1_21867929_ChIP-Seq_TH2_Mouse1.05119005
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.04333542
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04325201
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.03611830
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03315734
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02361977
114* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02342205
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02252182
116SMAD3_21741376_ChIP-Seq_ESCs_Human1.02109376
117IGF1R_20145208_ChIP-Seq_DFB_Human1.00957602
118* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00921242
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00600032
120* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99953591
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99834302
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99449126
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98920911
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98920911
125BCAT_22108803_ChIP-Seq_LS180_Human0.98334799
126JUN_21703547_ChIP-Seq_K562_Human0.98181660
127P53_22387025_ChIP-Seq_ESCs_Mouse0.96321791
128ISL1_27105846_Chip-Seq_CPCs_Mouse0.95778909
129KDM2B_26808549_Chip-Seq_REH_Human0.95442811
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95063556
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95044517
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.93740740
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92538272
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92145938
135TCF4_23295773_ChIP-Seq_U87_Human0.91174556
136* RUNX2_22187159_ChIP-Seq_PCA_Human0.89909598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction7.49668550
2MP0004859_abnormal_synaptic_plasticity3.90320176
3MP0006292_abnormal_olfactory_placode3.78252969
4MP0002822_catalepsy3.59801029
5MP0003787_abnormal_imprinting3.14970172
6MP0003635_abnormal_synaptic_transmissio2.89976755
7MP0003880_abnormal_central_pattern2.77841590
8MP0002909_abnormal_adrenal_gland2.71386857
9MP0004270_analgesia2.70874284
10MP0003283_abnormal_digestive_organ2.46480470
11MP0002063_abnormal_learning/memory/cond2.45082471
12MP0002638_abnormal_pupillary_reflex2.34051378
13MP0005551_abnormal_eye_electrophysiolog2.32907813
14MP0008877_abnormal_DNA_methylation2.29997770
15MP0005645_abnormal_hypothalamus_physiol2.18325803
16MP0001529_abnormal_vocalization2.14309350
17MP0003121_genomic_imprinting2.14176698
18MP0001486_abnormal_startle_reflex2.12220382
19MP0002184_abnormal_innervation2.10793793
20MP0002734_abnormal_mechanical_nocicepti2.10714755
21MP0009745_abnormal_behavioral_response2.09664071
22MP0005394_taste/olfaction_phenotype2.01834154
23MP0005499_abnormal_olfactory_system2.01834154
24MP0005423_abnormal_somatic_nervous1.97105919
25MP0002572_abnormal_emotion/affect_behav1.96245974
26MP0002272_abnormal_nervous_system1.94625699
27MP0002064_seizures1.92374205
28MP0002102_abnormal_ear_morphology1.82272494
29MP0001986_abnormal_taste_sensitivity1.76856590
30MP0009046_muscle_twitch1.74850394
31MP0005646_abnormal_pituitary_gland1.74456848
32MP0002837_dystrophic_cardiac_calcinosis1.73469490
33MP0004145_abnormal_muscle_electrophysio1.73309080
34MP0003122_maternal_imprinting1.72279843
35MP0002557_abnormal_social/conspecific_i1.67755225
36MP0000049_abnormal_middle_ear1.66436081
37MP0000013_abnormal_adipose_tissue1.63596972
38MP0008789_abnormal_olfactory_epithelium1.63440694
39MP0000751_myopathy1.63328320
40MP0000569_abnormal_digit_pigmentation1.54917733
41MP0001968_abnormal_touch/_nociception1.54627661
42MP0006276_abnormal_autonomic_nervous1.54003431
43MP0004133_heterotaxia1.52381130
44MP0000778_abnormal_nervous_system1.50615225
45MP0004142_abnormal_muscle_tone1.50344530
46MP0004811_abnormal_neuron_physiology1.50313930
47MP0006072_abnormal_retinal_apoptosis1.48569875
48MP0002882_abnormal_neuron_morphology1.46483052
49MP0004924_abnormal_behavior1.46225080
50MP0005386_behavior/neurological_phenoty1.46225080
51MP0002160_abnormal_reproductive_system1.45507645
52MP0010386_abnormal_urinary_bladder1.45296847
53MP0008961_abnormal_basal_metabolism1.40740418
54MP0002067_abnormal_sensory_capabilities1.38149297
55MP0009780_abnormal_chondrocyte_physiolo1.37839180
56MP0003123_paternal_imprinting1.36935322
57MP0000026_abnormal_inner_ear1.36850310
58MP0001970_abnormal_pain_threshold1.35749951
59MP0005253_abnormal_eye_physiology1.32536787
60MP0004215_abnormal_myocardial_fiber1.30187448
61MP0001963_abnormal_hearing_physiology1.25550237
62MP0003890_abnormal_embryonic-extraembry1.25530054
63MP0001502_abnormal_circadian_rhythm1.22977169
64MP0003938_abnormal_ear_development1.18065136
65MP0002752_abnormal_somatic_nervous1.16618082
66MP0002733_abnormal_thermal_nociception1.15371987
67MP0000955_abnormal_spinal_cord1.14977016
68MP0001501_abnormal_sleep_pattern1.13916922
69MP0008569_lethality_at_weaning1.12905050
70MP0004233_abnormal_muscle_weight1.11669976
71MP0002229_neurodegeneration1.10597715
72MP0002751_abnormal_autonomic_nervous1.10350803
73MP0002152_abnormal_brain_morphology1.09999947
74MP0004085_abnormal_heartbeat1.09804879
75MP0000003_abnormal_adipose_tissue1.09563491
76MP0003942_abnormal_urinary_system1.07398658
77MP0003646_muscle_fatigue1.07240127
78MP0004858_abnormal_nervous_system1.06541262
79MP0001293_anophthalmia1.06305004
80MP0003136_yellow_coat_color1.05734639
81MP0009379_abnormal_foot_pigmentation1.05233516
82MP0005389_reproductive_system_phenotype1.05130914
83MP0003137_abnormal_impulse_conducting1.04257852
84MP0000631_abnormal_neuroendocrine_gland1.04091886
85MP0003119_abnormal_digestive_system1.03725806
86MP0004036_abnormal_muscle_relaxation1.02620320
87MP0002066_abnormal_motor_capabilities/c1.01603074
88MP0002233_abnormal_nose_morphology1.01209910
89MP0002938_white_spotting1.00490550
90MP0002877_abnormal_melanocyte_morpholog0.99108049
91MP0003937_abnormal_limbs/digits/tail_de0.98421809
92MP0002234_abnormal_pharynx_morphology0.98215941
93MP0003315_abnormal_perineum_morphology0.97775119
94MP0001188_hyperpigmentation0.97656609
95MP0008872_abnormal_physiological_respon0.93052293
96MP0003633_abnormal_nervous_system0.91694343
97MP0004043_abnormal_pH_regulation0.91674110
98MP0004130_abnormal_muscle_cell0.91328059
99MP0003755_abnormal_palate_morphology0.90578726
100MP0005195_abnormal_posterior_eye0.90030165
101MP0003634_abnormal_glial_cell0.89193666
102MP0004885_abnormal_endolymph0.88422736
103MP0009053_abnormal_anal_canal0.87954857
104MP0000566_synostosis0.87073753
105MP0001299_abnormal_eye_distance/0.86964751
106MP0005187_abnormal_penis_morphology0.86168032
107MP0003567_abnormal_fetal_cardiomyocyte0.84956904
108MP0004484_altered_response_of0.83715734
109MP0002653_abnormal_ependyma_morphology0.83078051
110MP0008775_abnormal_heart_ventricle0.82287578
111MP0001944_abnormal_pancreas_morphology0.81921396
112MP0001440_abnormal_grooming_behavior0.80637586
113MP0002090_abnormal_vision0.80588471
114MP0001485_abnormal_pinna_reflex0.79606092
115MP0005084_abnormal_gallbladder_morpholo0.79510736
116MP0003011_delayed_dark_adaptation0.79072436
117MP0005620_abnormal_muscle_contractility0.78763885
118MP0002163_abnormal_gland_morphology0.78598934
119MP0002736_abnormal_nociception_after0.77947752
120MP0002735_abnormal_chemical_nociception0.77717842
121MP0002069_abnormal_eating/drinking_beha0.76802404
122MP0003879_abnormal_hair_cell0.76641251
123MP0001286_abnormal_eye_development0.73417253
124MP0003183_abnormal_peptide_metabolism0.71983432
125MP0002078_abnormal_glucose_homeostasis0.68759106
126MP0000747_muscle_weakness0.68186617
127MP0004087_abnormal_muscle_fiber0.66617302
128MP0004084_abnormal_cardiac_muscle0.65171400
129MP0005535_abnormal_body_temperature0.65085635
130MP0000759_abnormal_skeletal_muscle0.63455460
131MP0003861_abnormal_nervous_system0.63182798
132MP0005623_abnormal_meninges_morphology0.63074241
133MP0004742_abnormal_vestibular_system0.61106966
134MP0001905_abnormal_dopamine_level0.59658592
135MP0003631_nervous_system_phenotype0.58848359
136MP0002106_abnormal_muscle_physiology0.57916846

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)4.93735469
2Bony spicule pigmentary retinopathy (HP:0007737)4.68263144
3Myokymia (HP:0002411)4.24451126
4Abnormality of macular pigmentation (HP:0008002)4.20984158
5Congenital stationary night blindness (HP:0007642)3.94185767
6Toxemia of pregnancy (HP:0100603)3.86282178
7Focal motor seizures (HP:0011153)3.82001305
8Limb dystonia (HP:0002451)3.78508228
9Retinal dysplasia (HP:0007973)3.75010419
10Focal seizures (HP:0007359)3.53856555
11Visual hallucinations (HP:0002367)3.44826134
12Scotoma (HP:0000575)3.34742821
13Pancreatic fibrosis (HP:0100732)3.30185336
14Prolonged QT interval (HP:0001657)3.22153418
15Pancreatic cysts (HP:0001737)3.21090719
16Abnormal rod and cone electroretinograms (HP:0008323)3.16091621
17Thyroid-stimulating hormone excess (HP:0002925)3.13806695
18Atonic seizures (HP:0010819)3.09297658
19True hermaphroditism (HP:0010459)3.07054671
20Febrile seizures (HP:0002373)3.04896455
21Pendular nystagmus (HP:0012043)3.04803892
22Hyperglycinemia (HP:0002154)2.90985162
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88759190
24Torticollis (HP:0000473)2.85602202
25Depression (HP:0000716)2.85195947
26Abnormality of the labia minora (HP:0012880)2.80857149
27Limb hypertonia (HP:0002509)2.76990069
28Absence seizures (HP:0002121)2.76338364
29Ankle clonus (HP:0011448)2.75522978
30Nephronophthisis (HP:0000090)2.64881060
31Abnormality of midbrain morphology (HP:0002418)2.64632556
32Molar tooth sign on MRI (HP:0002419)2.64632556
33Pheochromocytoma (HP:0002666)2.62790632
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.57291284
35Gait imbalance (HP:0002141)2.55518758
36Anxiety (HP:0000739)2.52860575
37Septo-optic dysplasia (HP:0100842)2.52736437
38Generalized tonic-clonic seizures (HP:0002069)2.51363813
39Epileptic encephalopathy (HP:0200134)2.51051336
40Abolished electroretinogram (ERG) (HP:0000550)2.49808038
41Genetic anticipation (HP:0003743)2.49766756
42Bifid tongue (HP:0010297)2.49442171
43Syncope (HP:0001279)2.49068431
44Abnormal EKG (HP:0003115)2.47233152
45Type II diabetes mellitus (HP:0005978)2.43916858
46Polyphagia (HP:0002591)2.41875344
47Agitation (HP:0000713)2.40728132
48Congenital primary aphakia (HP:0007707)2.39797507
49Sclerocornea (HP:0000647)2.39599129
50Craniofacial dystonia (HP:0012179)2.38893945
51Focal dystonia (HP:0004373)2.37729197
52Palpitations (HP:0001962)2.37147547
53Action tremor (HP:0002345)2.36143111
54Optic nerve hypoplasia (HP:0000609)2.34933264
55Poor eye contact (HP:0000817)2.34456257
56Abnormality of the renal medulla (HP:0100957)2.33147780
57Chronic hepatic failure (HP:0100626)2.31460837
58Abnormality of the renal cortex (HP:0011035)2.28102132
59Macroorchidism (HP:0000053)2.28021162
60Dysphonia (HP:0001618)2.27741797
61Dialeptic seizures (HP:0011146)2.26017779
62Truncal ataxia (HP:0002078)2.25956713
63Papilledema (HP:0001085)2.23970804
64Exercise-induced myalgia (HP:0003738)2.22487535
65Pachygyria (HP:0001302)2.17683252
66Sudden death (HP:0001699)2.14539304
67Abnormal social behavior (HP:0012433)2.13915536
68Impaired social interactions (HP:0000735)2.13915536
69Neuroendocrine neoplasm (HP:0100634)2.13344873
70Lissencephaly (HP:0001339)2.12606225
71Primary atrial arrhythmia (HP:0001692)2.12370391
72Specific learning disability (HP:0001328)2.11867363
73Atrial fibrillation (HP:0005110)2.11671299
74Nephrogenic diabetes insipidus (HP:0009806)2.11644827
75Adrenal hypoplasia (HP:0000835)2.10868604
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10164569
77Abnormal eating behavior (HP:0100738)2.08239546
78Severe visual impairment (HP:0001141)2.03392738
79Retinitis pigmentosa (HP:0000510)2.02304683
80Urinary urgency (HP:0000012)2.02175460
81Failure to thrive in infancy (HP:0001531)2.02115125
82Medial flaring of the eyebrow (HP:0010747)2.01980768
83EEG with generalized epileptiform discharges (HP:0011198)2.00823023
84Rib fusion (HP:0000902)1.98795024
85Agnosia (HP:0010524)1.98732231
86Abnormality of the nasal septum (HP:0000419)1.98489569
87Left ventricular hypertrophy (HP:0001712)1.98303348
88Broad-based gait (HP:0002136)1.97574767
89Supraventricular tachycardia (HP:0004755)1.97155366
90Chorioretinal atrophy (HP:0000533)1.95702487
91Hepatoblastoma (HP:0002884)1.95653655
92Ventricular fibrillation (HP:0001663)1.95371348
93Epileptiform EEG discharges (HP:0011182)1.93525029
94Impaired vibration sensation in the lower limbs (HP:0002166)1.92794152
95Anencephaly (HP:0002323)1.92409434
96Dyschromatopsia (HP:0007641)1.92087263
97Renal cortical cysts (HP:0000803)1.91871153
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.91861938
99Absent/shortened dynein arms (HP:0200106)1.91861938
100Insidious onset (HP:0003587)1.91372463
101Termporal pattern (HP:0011008)1.91372463
102Supraventricular arrhythmia (HP:0005115)1.91200942
103Impaired pain sensation (HP:0007328)1.91177495
104Abnormality of pain sensation (HP:0010832)1.91177495
105Type II lissencephaly (HP:0007260)1.90614333
106Acute encephalopathy (HP:0006846)1.90583982
107Stenosis of the external auditory canal (HP:0000402)1.89830556
108Drooling (HP:0002307)1.89141169
109Excessive salivation (HP:0003781)1.89141169
110Hypsarrhythmia (HP:0002521)1.88994113
111Constricted visual fields (HP:0001133)1.88430314
112Dysdiadochokinesis (HP:0002075)1.87658160
113Vaginal atresia (HP:0000148)1.87312651
114Male pseudohermaphroditism (HP:0000037)1.87312452
115Ependymoma (HP:0002888)1.87202036
116Neoplasm of the heart (HP:0100544)1.86822117
117Postaxial foot polydactyly (HP:0001830)1.86677145
118Hypothermia (HP:0002045)1.86413771
119Dyskinesia (HP:0100660)1.85511552
120Resting tremor (HP:0002322)1.85258803
121Keratoconus (HP:0000563)1.84621104
122Increased corneal curvature (HP:0100692)1.84621104
123Hamartoma of the eye (HP:0010568)1.84053763
124Cystic liver disease (HP:0006706)1.83013998
125Stereotypic behavior (HP:0000733)1.82692307
126Volvulus (HP:0002580)1.82263577
127Small hand (HP:0200055)1.81574626
128Growth hormone deficiency (HP:0000824)1.80998640
129Pigmentary retinal degeneration (HP:0001146)1.79796955
130Amblyopia (HP:0000646)1.79584484
1313-Methylglutaconic aciduria (HP:0003535)1.79332272
132Supranuclear gaze palsy (HP:0000605)1.78670779
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.78656400
134Genital tract atresia (HP:0001827)1.78323090
135Inability to walk (HP:0002540)1.77878688
136Acute necrotizing encephalopathy (HP:0006965)1.77244186
137Protruding tongue (HP:0010808)1.76981129
138Rhabdomyosarcoma (HP:0002859)1.76804730
139Gaze-evoked nystagmus (HP:0000640)1.76766916
140Progressive cerebellar ataxia (HP:0002073)1.76360759
141Oligodactyly (hands) (HP:0001180)1.75758380
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.74293831
143Decreased circulating renin level (HP:0003351)1.74291907
144Obsessive-compulsive behavior (HP:0000722)1.73848938
145Hyperventilation (HP:0002883)1.73373387
146Postaxial hand polydactyly (HP:0001162)1.73217809
147Anosmia (HP:0000458)1.72717319
148Attenuation of retinal blood vessels (HP:0007843)1.71966000
149Progressive inability to walk (HP:0002505)1.71619170
150Menstrual irregularities (HP:0000858)1.71159491
151Myotonia (HP:0002486)1.70624315
152Abnormal respiratory epithelium morphology (HP:0012253)1.70105443
153Abnormal respiratory motile cilium morphology (HP:0005938)1.70105443
154Urinary bladder sphincter dysfunction (HP:0002839)1.67506008
155Astrocytoma (HP:0009592)1.67271725
156Abnormality of the astrocytes (HP:0100707)1.67271725
157Abnormal ciliary motility (HP:0012262)1.66575772
158Calf muscle hypertrophy (HP:0008981)1.66421947
159Megalencephaly (HP:0001355)1.66349114
160Patellar aplasia (HP:0006443)1.64026304
161Aplasia/Hypoplasia of the patella (HP:0006498)1.63920516
162Decreased muscle mass (HP:0003199)1.60636514
163Decreased central vision (HP:0007663)1.59209535
164Hip dysplasia (HP:0001385)1.59088206
165Abnormality of serine family amino acid metabolism (HP:0010894)1.58738598
166Abnormality of glycine metabolism (HP:0010895)1.58738598
167Maternal diabetes (HP:0009800)1.58617824
168Narrow forehead (HP:0000341)1.58265737
169Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.58247388
170Short 4th metacarpal (HP:0010044)1.58247388
171Abnormality of cochlea (HP:0000375)1.58011340
172Prenatal maternal abnormality (HP:0002686)1.57572653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG13.30284754
2PHKG23.30284754
3NTRK32.96993466
4EPHA42.77826345
5MARK12.59273201
6PRKD32.53248326
7MAP3K92.51899650
8MINK12.21999969
9MAP3K42.14571328
10KSR12.11161642
11EPHB22.01576655
12PAK31.92969222
13DYRK21.89187023
14MAP4K21.87812062
15TRIB31.87382567
16DAPK21.87273365
17ADRBK21.87269771
18PAK61.84197941
19NTRK21.83707610
20PNCK1.83433972
21ERBB31.81182229
22KSR21.77378082
23CAMKK21.73644200
24CAMKK11.69581390
25ZAK1.64504965
26NTRK11.62169980
27GRK11.60589047
28MAPK151.60369478
29MAP3K21.59534910
30PIK3CA1.49561446
31SIK21.48856002
32INSRR1.48457290
33CAMK1G1.40822233
34TNIK1.40019531
35MAP2K71.39891152
36TYRO31.36899307
37PKN11.34317901
38CDK51.31762140
39UHMK11.27359843
40BMPR1B1.26737186
41CAMK2D1.25843141
42BCKDK1.25709141
43NEK11.25237377
44SGK2231.24428152
45SGK4941.24428152
46MAP2K41.24007631
47MAPK131.21607824
48CAMK2B1.18821812
49SIK31.18610375
50CAMK1D1.15723558
51WNK41.12972797
52HIPK21.12725655
53TRIM281.10241845
54PRKCE1.09557873
55PDGFRA1.07059156
56PLK41.06406157
57FGFR21.04976711
58AKT31.03780994
59TAF11.03556758
60RET1.03072603
61MKNK21.02789085
62ICK1.01921152
63STK381.01313501
64PINK11.01227585
65PRKCH0.99699982
66PLK20.97990257
67DAPK10.95817526
68FRK0.94094368
69SGK20.92644331
70RIPK10.92452335
71PRKCG0.89666652
72TEC0.88526629
73NUAK10.87499289
74ARAF0.86779493
75PKN20.86019537
76CDK190.85879165
77TIE10.84247340
78MARK20.81729556
79CDC70.79889683
80CAMK2G0.78917259
81CAMK2A0.78584393
82CSNK1G20.77606378
83SGK30.75028886
84OXSR10.74773984
85TAOK30.72945657
86CSNK1G10.72045257
87DYRK1A0.71116063
88DMPK0.70267492
89ADRBK10.69345318
90WNK30.69091034
91RPS6KA20.68995215
92MAPKAPK30.68375382
93TXK0.68312841
94STK390.66500751
95STK38L0.66430657
96PRKACA0.66301735
97IRAK20.65530163
98EEF2K0.63357237
99CSNK1A1L0.63178867
100TSSK60.63080947
101FER0.62842275
102ITK0.62279621
103CAMK10.60577785
104SCYL20.60574319
105CAMK40.59657340
106STK110.59423774
107LMTK20.58626106
108TAOK10.57851015
109PRKCQ0.55174249
110PRKG10.54067072
111ERBB20.53772763
112MAP3K10.53368373
113PRKCZ0.53191682
114PRKAA10.52764322
115PLK10.51968880
116MAPK100.51796317
117CSNK1G30.51153764
118MAP3K70.50839596
119STK160.50523215
120RPS6KA50.49571162
121CSNK1E0.49138085
122WNK10.48546378
123OBSCN0.48532444
124SRPK10.48409596
125WEE10.47801605
126MKNK10.47525612
127CDK180.47426100
128BCR0.46848988
129SGK10.46821576
130CASK0.46576297
131RPS6KA30.46498396
132TTN0.45936816
133PRKD20.45705045
134CDK140.45207633
135GRK50.44107657
136GRK70.43675573
137RPS6KA40.43579456
138FES0.42873061
139ABL20.42649174
140PRKACG0.42370070
141FGFR10.41644305
142PRKCA0.41237240
143MAP3K120.41149590
144CDC42BPA0.40933708
145CSNK1A10.40402962
146MAP2K10.40292548
147VRK10.39357242
148PDPK10.39278142
149PASK0.38653670
150CSNK1D0.37809957
151CDK30.36843085
152TLK10.36682574
153PRKCB0.36118035

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.83741357
2Phototransduction_Homo sapiens_hsa047443.91763034
3Oxidative phosphorylation_Homo sapiens_hsa001902.53105104
4Insulin secretion_Homo sapiens_hsa049112.34687535
5Circadian entrainment_Homo sapiens_hsa047132.34422766
6Synaptic vesicle cycle_Homo sapiens_hsa047212.30693850
7Morphine addiction_Homo sapiens_hsa050322.26382170
8GABAergic synapse_Homo sapiens_hsa047272.25820266
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.22556033
10Dopaminergic synapse_Homo sapiens_hsa047282.15956276
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10603661
12Cholinergic synapse_Homo sapiens_hsa047252.02763012
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94438436
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86499208
15Glutamatergic synapse_Homo sapiens_hsa047241.82510027
16Nicotine addiction_Homo sapiens_hsa050331.82139243
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80408507
18Amphetamine addiction_Homo sapiens_hsa050311.80315284
19Long-term potentiation_Homo sapiens_hsa047201.76008868
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73984152
21Propanoate metabolism_Homo sapiens_hsa006401.65923009
22Cocaine addiction_Homo sapiens_hsa050301.64286964
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60515474
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56458752
25Huntingtons disease_Homo sapiens_hsa050161.55756637
26Fanconi anemia pathway_Homo sapiens_hsa034601.52726110
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51464578
28Salivary secretion_Homo sapiens_hsa049701.50832581
29Taste transduction_Homo sapiens_hsa047421.48650703
30Renin secretion_Homo sapiens_hsa049241.48455931
31Gastric acid secretion_Homo sapiens_hsa049711.47759332
32Oxytocin signaling pathway_Homo sapiens_hsa049211.47193680
33RNA polymerase_Homo sapiens_hsa030201.44967865
34Linoleic acid metabolism_Homo sapiens_hsa005911.40878944
35cAMP signaling pathway_Homo sapiens_hsa040241.37074338
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36508876
37Gap junction_Homo sapiens_hsa045401.35633544
38Calcium signaling pathway_Homo sapiens_hsa040201.32187134
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31442936
40Ribosome_Homo sapiens_hsa030101.31336154
41Dilated cardiomyopathy_Homo sapiens_hsa054141.28308374
42Type II diabetes mellitus_Homo sapiens_hsa049301.28103877
43Selenocompound metabolism_Homo sapiens_hsa004501.27429543
44Serotonergic synapse_Homo sapiens_hsa047261.26082854
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24696260
46Steroid biosynthesis_Homo sapiens_hsa001001.24184426
47Protein export_Homo sapiens_hsa030601.23975291
48GnRH signaling pathway_Homo sapiens_hsa049121.22760665
49Basal transcription factors_Homo sapiens_hsa030221.17524481
50Vibrio cholerae infection_Homo sapiens_hsa051101.13473413
51Cardiac muscle contraction_Homo sapiens_hsa042601.13337148
52Mismatch repair_Homo sapiens_hsa034301.13298759
53Estrogen signaling pathway_Homo sapiens_hsa049151.11822801
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11020204
55Hedgehog signaling pathway_Homo sapiens_hsa043401.10640430
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08292310
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06422793
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05060789
59Homologous recombination_Homo sapiens_hsa034401.02779767
60Glucagon signaling pathway_Homo sapiens_hsa049221.02666233
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02642708
62Thyroid hormone synthesis_Homo sapiens_hsa049181.01218057
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00810770
64Melanogenesis_Homo sapiens_hsa049160.99301852
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98945300
66Alcoholism_Homo sapiens_hsa050340.98790994
67Tryptophan metabolism_Homo sapiens_hsa003800.96472068
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96386774
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.95191644
70Retinol metabolism_Homo sapiens_hsa008300.95030209
71Basal cell carcinoma_Homo sapiens_hsa052170.94525072
72Sulfur relay system_Homo sapiens_hsa041220.93049499
73Glioma_Homo sapiens_hsa052140.92342606
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.91778444
75RNA degradation_Homo sapiens_hsa030180.91165475
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90832367
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90215411
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.89184454
79Ether lipid metabolism_Homo sapiens_hsa005650.88461327
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87798682
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83971180
82Insulin signaling pathway_Homo sapiens_hsa049100.83690107
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82780711
84Glycerolipid metabolism_Homo sapiens_hsa005610.81499040
85Caffeine metabolism_Homo sapiens_hsa002320.81081143
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80896816
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80365006
88Oocyte meiosis_Homo sapiens_hsa041140.80069066
89Axon guidance_Homo sapiens_hsa043600.79962717
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.78912328
91Pyruvate metabolism_Homo sapiens_hsa006200.78735826
92Pancreatic secretion_Homo sapiens_hsa049720.78716945
93Peroxisome_Homo sapiens_hsa041460.78534167
94beta-Alanine metabolism_Homo sapiens_hsa004100.77915447
95mTOR signaling pathway_Homo sapiens_hsa041500.75953622
96Long-term depression_Homo sapiens_hsa047300.75037011
97Circadian rhythm_Homo sapiens_hsa047100.73820907
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73267850
99Chemical carcinogenesis_Homo sapiens_hsa052040.72500080
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71110722
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70681339
102ErbB signaling pathway_Homo sapiens_hsa040120.68180382
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.67720120
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66667757
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.65710150
106Endometrial cancer_Homo sapiens_hsa052130.65683800
107Hippo signaling pathway_Homo sapiens_hsa043900.63538637
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.62151401
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60353347
110Rap1 signaling pathway_Homo sapiens_hsa040150.60177974
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59171461
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58884533
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58386577
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57870836
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57496306
116MAPK signaling pathway_Homo sapiens_hsa040100.57146073
117Ovarian steroidogenesis_Homo sapiens_hsa049130.56688359
118Renal cell carcinoma_Homo sapiens_hsa052110.56445192
119Bile secretion_Homo sapiens_hsa049760.56211551
120Dorso-ventral axis formation_Homo sapiens_hsa043200.55679434
121Nitrogen metabolism_Homo sapiens_hsa009100.55607031
122Collecting duct acid secretion_Homo sapiens_hsa049660.52228616
123Purine metabolism_Homo sapiens_hsa002300.51603883
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50803134
125Insulin resistance_Homo sapiens_hsa049310.50765246
126Fatty acid elongation_Homo sapiens_hsa000620.49635788
127AMPK signaling pathway_Homo sapiens_hsa041520.49413950
128Type I diabetes mellitus_Homo sapiens_hsa049400.48662717
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48597558
130Spliceosome_Homo sapiens_hsa030400.48122731
131Colorectal cancer_Homo sapiens_hsa052100.47810170
132Non-small cell lung cancer_Homo sapiens_hsa052230.47190337
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46565164
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46385495
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46065352
136Ras signaling pathway_Homo sapiens_hsa040140.45456916
137Inositol phosphate metabolism_Homo sapiens_hsa005620.44627297
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44566715
139Metabolic pathways_Homo sapiens_hsa011000.43255080
140RNA transport_Homo sapiens_hsa030130.42651198
141VEGF signaling pathway_Homo sapiens_hsa043700.42561086
142Butanoate metabolism_Homo sapiens_hsa006500.41693296
143Regulation of autophagy_Homo sapiens_hsa041400.40879538
144Prion diseases_Homo sapiens_hsa050200.40669648
145Choline metabolism in cancer_Homo sapiens_hsa052310.40528675
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.40186805
147Parkinsons disease_Homo sapiens_hsa050120.39196529
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36904957
149Alzheimers disease_Homo sapiens_hsa050100.33921979
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31513679
151N-Glycan biosynthesis_Homo sapiens_hsa005100.31093760
152Wnt signaling pathway_Homo sapiens_hsa043100.30744986
153Prolactin signaling pathway_Homo sapiens_hsa049170.29830631
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28772077
155Endocytosis_Homo sapiens_hsa041440.28397454
156Adipocytokine signaling pathway_Homo sapiens_hsa049200.26586187
157Chemokine signaling pathway_Homo sapiens_hsa040620.26380059
158Platelet activation_Homo sapiens_hsa046110.25962687

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »