RICTOR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.56532384
2neural tube formation (GO:0001841)4.47318383
3regulation of B cell receptor signaling pathway (GO:0050855)4.41507679
4cytoplasmic mRNA processing body assembly (GO:0033962)4.30773142
5protein K11-linked deubiquitination (GO:0035871)4.26125772
6nuclear pore complex assembly (GO:0051292)3.80088141
7positive regulation of granulocyte differentiation (GO:0030854)3.70479158
8detection of molecule of bacterial origin (GO:0032490)3.68574734
9cellular response to ethanol (GO:0071361)3.68295257
10activated T cell proliferation (GO:0050798)3.66498282
11regulation of RNA export from nucleus (GO:0046831)3.59209125
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.55904593
13negative regulation of translation, ncRNA-mediated (GO:0040033)3.55904593
14regulation of translation, ncRNA-mediated (GO:0045974)3.55904593
15histone H3-K4 methylation (GO:0051568)3.49575199
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37328485
17interkinetic nuclear migration (GO:0022027)3.36002011
18hepatocyte apoptotic process (GO:0097284)3.35889454
19histone H3-K9 demethylation (GO:0033169)3.35545149
20histone H3-K36 demethylation (GO:0070544)3.33634034
21response to interleukin-15 (GO:0070672)3.31057314
22negative regulation of cAMP-mediated signaling (GO:0043951)3.30450634
23microglial cell activation (GO:0001774)3.27946880
24cellular extravasation (GO:0045123)3.27886705
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27387183
26peptidyl-lysine trimethylation (GO:0018023)3.26824804
27mitotic sister chromatid cohesion (GO:0007064)3.23075027
28regulation of establishment of cell polarity (GO:2000114)3.21522347
29retinal cone cell development (GO:0046549)3.15555283
30nuclear pore organization (GO:0006999)3.15303288
31nerve growth factor signaling pathway (GO:0038180)3.14383798
32phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.13549585
33positive regulation by symbiont of host defense response (GO:0052509)3.11877763
34modulation by symbiont of host defense response (GO:0052031)3.11877763
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.11877763
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.11877763
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.11877763
38modulation by symbiont of host immune response (GO:0052553)3.11877763
39prenylation (GO:0097354)3.11727830
40protein prenylation (GO:0018342)3.11727830
41neutrophil mediated immunity (GO:0002446)3.09013156
42histone mRNA catabolic process (GO:0071044)3.08568321
43regulation of nucleobase-containing compound transport (GO:0032239)3.02607398
44cellular response to interleukin-15 (GO:0071350)2.98091878
45regulation of protein polyubiquitination (GO:1902914)2.97844344
46positive regulation of gamma-delta T cell activation (GO:0046645)2.96021671
47interferon-gamma production (GO:0032609)2.95312535
48histone lysine demethylation (GO:0070076)2.90276910
49detection of light stimulus involved in sensory perception (GO:0050962)2.87438709
50detection of light stimulus involved in visual perception (GO:0050908)2.87438709
51Golgi to endosome transport (GO:0006895)2.85284354
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84833828
53negative regulation of neurotransmitter transport (GO:0051589)2.83728086
54negative regulation of T cell mediated immunity (GO:0002710)2.83127483
55positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.81372681
56regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.81372681
57regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.81181046
58positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.81181046
59B cell receptor signaling pathway (GO:0050853)2.80051251
60definitive hemopoiesis (GO:0060216)2.78756062
61negative regulation of T-helper cell differentiation (GO:0045623)2.78550726
62negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.78550726
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77816820
64myeloid leukocyte mediated immunity (GO:0002444)2.77529715
65regulation of MHC class I biosynthetic process (GO:0045343)2.76132052
66histone demethylation (GO:0016577)2.73572252
67negative regulation of lymphocyte mediated immunity (GO:0002707)2.70773122
68cerebellar Purkinje cell differentiation (GO:0021702)2.69457954
69negative regulation of B cell proliferation (GO:0030889)2.69399990
70establishment of nucleus localization (GO:0040023)2.68740220
71macrophage activation involved in immune response (GO:0002281)2.68605620
72regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.67709032
73cAMP catabolic process (GO:0006198)2.66442581
74negative T cell selection (GO:0043383)2.65783792
75negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.64387593
76negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.63765956
77tolerance induction (GO:0002507)2.63603472
78macrophage activation (GO:0042116)2.63585571
79protein K63-linked deubiquitination (GO:0070536)2.62942156
80regulation of memory T cell differentiation (GO:0043380)2.62595906
81pre-miRNA processing (GO:0031054)2.59761006
82protein targeting to vacuole (GO:0006623)2.59594386
83protein targeting to lysosome (GO:0006622)2.59594386
84establishment of protein localization to vacuole (GO:0072666)2.59594386
85response to pheromone (GO:0019236)2.57641112
86regulation of establishment or maintenance of cell polarity (GO:0032878)2.57310214
87regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.56810911
88histone lysine methylation (GO:0034968)2.56632045
89protein localization to Golgi apparatus (GO:0034067)2.55984729
90negative regulation of cell killing (GO:0031342)2.54685153
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54685153
92negative regulation of immunoglobulin mediated immune response (GO:0002890)2.54197707
93negative regulation of B cell mediated immunity (GO:0002713)2.54197707
94cyclic nucleotide catabolic process (GO:0009214)2.53897343
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.53645292
96negative regulation of neurotransmitter secretion (GO:0046929)2.53590702
97locomotory exploration behavior (GO:0035641)2.53238640
98peptidyl-lysine methylation (GO:0018022)2.52924803
99regulation of mRNA catabolic process (GO:0061013)2.52860015
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.52724928
101pore complex assembly (GO:0046931)2.52369549
102macroautophagy (GO:0016236)2.51799516
103regulation of necroptotic process (GO:0060544)2.49122245
104positive regulation of mRNA catabolic process (GO:0061014)2.49053591
105L-amino acid import (GO:0043092)2.48769747
106melanin biosynthetic process (GO:0042438)2.48254351
107protein demethylation (GO:0006482)2.47798842
108protein dealkylation (GO:0008214)2.47798842
109alpha-beta T cell differentiation (GO:0046632)2.46882179
110positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.46551015
111negative regulation of adaptive immune response (GO:0002820)2.45687892
112regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.45391574
113regulation of interferon-beta biosynthetic process (GO:0045357)2.43737681
114phospholipid translocation (GO:0045332)2.43090795
115lipid translocation (GO:0034204)2.43090795
116response to host immune response (GO:0052572)2.42634453
117negative thymic T cell selection (GO:0045060)2.39753967
118establishment of protein localization to Golgi (GO:0072600)2.37258750
119negative regulation of histone methylation (GO:0031061)2.35386172
120regulation of ARF protein signal transduction (GO:0032012)2.34980336
121regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.34663779
122melanin metabolic process (GO:0006582)2.33388370
123dendrite morphogenesis (GO:0048813)2.31675719
124heterotypic cell-cell adhesion (GO:0034113)2.29209458
125retrograde transport, vesicle recycling within Golgi (GO:0000301)2.27862913
126regulation of short-term neuronal synaptic plasticity (GO:0048172)2.27295711
127regulation of gamma-delta T cell differentiation (GO:0045586)2.26945822
128positive T cell selection (GO:0043368)2.25822959
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.22921465
130cellular potassium ion homeostasis (GO:0030007)2.22893969
131regulation of gamma-delta T cell activation (GO:0046643)2.21939088
132histone H3-K9 methylation (GO:0051567)2.20370630
133insulin-like growth factor receptor signaling pathway (GO:0048009)2.20297930
134histone H3-K9 modification (GO:0061647)2.19713157
135regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.18654379
136protein targeting to Golgi (GO:0000042)2.17063209
137stress granule assembly (GO:0034063)2.16820478
138regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.15706208
139Rap protein signal transduction (GO:0032486)2.14790415
140T-helper cell differentiation (GO:0042093)2.14567755
141CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.14567755
142T cell selection (GO:0045058)2.14006433
143positive regulation of mRNA processing (GO:0050685)2.13932226
144monoubiquitinated protein deubiquitination (GO:0035520)2.12600283
145CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.12411017
146protein K48-linked deubiquitination (GO:0071108)2.11635967
147neural tube development (GO:0021915)2.09594055
148phosphatidylinositol dephosphorylation (GO:0046856)2.08871038
149retinal rod cell development (GO:0046548)2.07822565
150regulation of mRNA 3-end processing (GO:0031440)2.05823912
151positive regulation of mRNA metabolic process (GO:1903313)2.05743129
152cerebellar granule cell differentiation (GO:0021707)2.05410491
153positive regulation of interleukin-2 production (GO:0032743)2.05169982
154eye photoreceptor cell differentiation (GO:0001754)2.04396288
155photoreceptor cell differentiation (GO:0046530)2.04396288
156positive regulation of mRNA 3-end processing (GO:0031442)2.04181527
157positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.04146673
158regulation of interleukin-12 biosynthetic process (GO:0045075)2.02102923
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.00308472
160protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.00294181
161regulation of DNA endoreduplication (GO:0032875)2.00163644
162gamma-aminobutyric acid signaling pathway (GO:0007214)1.98203610
163positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)1.98116542
164germ cell migration (GO:0008354)1.97811686
165nucleus localization (GO:0051647)1.97437093
166replicative senescence (GO:0090399)1.97142072
167leukocyte aggregation (GO:0070486)1.96612501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.07484921
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.19663692
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.15893697
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.11384094
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85777859
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62313878
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.59463286
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.55286741
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26401787
10* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24156314
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.19178855
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16900533
13GBX2_23144817_ChIP-Seq_PC3_Human2.15320911
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06400103
15RUNX_20019798_ChIP-Seq_JUKART_Human2.03696282
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.99789869
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.98819500
18AR_21572438_ChIP-Seq_LNCaP_Human1.93878449
19TP53_16413492_ChIP-PET_HCT116_Human1.89061497
20* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82526221
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78763892
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74221680
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69226687
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64477950
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61970194
26DROSHA_22980978_ChIP-Seq_HELA_Human1.61284917
27VDR_22108803_ChIP-Seq_LS180_Human1.58117799
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.58001681
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56344366
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55322755
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52478561
32STAT3_23295773_ChIP-Seq_U87_Human1.51527667
33SMAD4_21799915_ChIP-Seq_A2780_Human1.50440716
34CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.50025114
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49390383
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48472742
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47427551
38CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45301572
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.44902118
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43058446
41ZNF274_21170338_ChIP-Seq_K562_Hela1.41331701
42TAF15_26573619_Chip-Seq_HEK293_Human1.40682825
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.40004053
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39087701
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37582606
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37287959
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.36971270
48TCF4_23295773_ChIP-Seq_U87_Human1.36538087
49SCL_19346495_ChIP-Seq_HPC-7_Human1.35582017
50BCAT_22108803_ChIP-Seq_LS180_Human1.35042422
51* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34927603
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.34673597
53FLI1_21867929_ChIP-Seq_TH2_Mouse1.34528091
54* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33794544
55* IRF8_27001747_Chip-Seq_BMDM_Mouse1.33787974
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.31967760
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31396215
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31179623
59CBP_20019798_ChIP-Seq_JUKART_Human1.31179623
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30233603
61* MYB_26560356_Chip-Seq_TH2_Human1.30155687
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28473219
63* FUS_26573619_Chip-Seq_HEK293_Human1.28300702
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26751469
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.26407508
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25562268
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24750793
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24663521
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24611919
70OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22693006
71* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22668183
72AHR_22903824_ChIP-Seq_MCF-7_Human1.20840911
73P300_19829295_ChIP-Seq_ESCs_Human1.20110879
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19112879
75* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17805953
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17632591
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15913561
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.15664059
79P53_22387025_ChIP-Seq_ESCs_Mouse1.15584782
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15372827
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15372827
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.15137127
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13181181
84GATA3_27048872_Chip-Seq_THYMUS_Human1.13079612
85* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13038309
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13000812
87* BRD4_25478319_ChIP-Seq_HGPS_Human1.12858126
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12633294
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12286931
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11508148
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11402422
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11308376
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11284618
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.10888719
95* AR_19668381_ChIP-Seq_PC3_Human1.10654018
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10330501
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09334698
98GATA3_26560356_Chip-Seq_TH2_Human1.09225875
99AR_25329375_ChIP-Seq_VCAP_Human1.09221511
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.08857188
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08837885
102E2F7_22180533_ChIP-Seq_HELA_Human1.08588814
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08243843
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07145053
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06930068
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06075691
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06075691
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.05497502
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04991447
110RXR_22108803_ChIP-Seq_LS180_Human1.04545247
111EWS_26573619_Chip-Seq_HEK293_Human1.03623647
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03331975
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03197448
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01662917
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00224229
116ER_23166858_ChIP-Seq_MCF-7_Human1.00177593
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99779792
118RARB_27405468_Chip-Seq_BRAIN_Mouse0.98520441
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98258129
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97727893
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97654230
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.96754454
123NANOG_18555785_Chip-Seq_ESCs_Mouse0.96623049
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96332960
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96287230
126TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96082010
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95388716
128TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94945973
129ISL1_27105846_Chip-Seq_CPCs_Mouse0.93704463
130VDR_24787735_ChIP-Seq_THP-1_Human0.92820646
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91739248
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91069282
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.90735886
134* FOXO3_23340844_ChIP-Seq_DLD1_Human0.88859512
135CJUN_26792858_Chip-Seq_BT549_Human0.88410606
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.88331444
137PRDM14_20953172_ChIP-Seq_ESCs_Human0.87541197
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87391637
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86016195
140FOXM1_23109430_ChIP-Seq_U2OS_Human0.85382686
141TCF7_22412390_ChIP-Seq_EML_Mouse0.84222266
142PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84130517
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.83752564
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.82776977
145IGF1R_20145208_ChIP-Seq_DFB_Human0.82403900
146GATA1_22025678_ChIP-Seq_K562_Human0.81905954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.40138227
2MP0003724_increased_susceptibility_to3.91142860
3MP0005171_absent_coat_pigmentation3.29353701
4MP0003787_abnormal_imprinting2.88471457
5MP0005551_abnormal_eye_electrophysiolog2.68803536
6MP0008877_abnormal_DNA_methylation2.44655997
7MP0001835_abnormal_antigen_presentation2.41992501
8MP0002009_preneoplasia2.38689508
9MP0003195_calcinosis2.22824544
10MP0010352_gastrointestinal_tract_polyps2.11334148
11MP0004381_abnormal_hair_follicle2.06992668
12MP0002166_altered_tumor_susceptibility2.05871190
13MP0003045_fibrosis2.03985606
14MP0002006_tumorigenesis1.96095699
15MP0003656_abnormal_erythrocyte_physiolo1.95854579
16MP0010234_abnormal_vibrissa_follicle1.94132034
17MP0005248_abnormal_Harderian_gland1.92515842
18MP0000372_irregular_coat_pigmentation1.82325652
19MP0003950_abnormal_plasma_membrane1.81618870
20MP0005076_abnormal_cell_differentiation1.81208077
21MP0004859_abnormal_synaptic_plasticity1.79017889
22MP0009278_abnormal_bone_marrow1.76113077
23MP0004130_abnormal_muscle_cell1.74092445
24MP0005408_hypopigmentation1.71838128
25MP0003252_abnormal_bile_duct1.71700687
26MP0005174_abnormal_tail_pigmentation1.71275984
27MP0002877_abnormal_melanocyte_morpholog1.70422536
28MP0010307_abnormal_tumor_latency1.70139856
29MP0005253_abnormal_eye_physiology1.66294367
30MP0003091_abnormal_cell_migration1.66045800
31MP0003121_genomic_imprinting1.65294921
32MP0005075_abnormal_melanosome_morpholog1.62729114
33MP0004484_altered_response_of1.62123178
34MP0004808_abnormal_hematopoietic_stem1.61581263
35MP0006072_abnormal_retinal_apoptosis1.61237955
36MP0003763_abnormal_thymus_physiology1.60572235
37MP0003300_gastrointestinal_ulcer1.59404157
38MP0000733_abnormal_muscle_development1.58132709
39MP0002723_abnormal_immune_serum1.56297104
40MP0003890_abnormal_embryonic-extraembry1.55249128
41MP0002090_abnormal_vision1.49398467
42MP0005623_abnormal_meninges_morphology1.48939275
43MP0000920_abnormal_myelination1.45297953
44MP0002420_abnormal_adaptive_immunity1.44911016
45MP0003828_pulmonary_edema1.43458095
46MP0001819_abnormal_immune_cell1.42789356
47MP0000371_diluted_coat_color1.40826817
48MP0001299_abnormal_eye_distance/1.39695027
49MP0002419_abnormal_innate_immunity1.39152000
50MP0005000_abnormal_immune_tolerance1.38569668
51MP0001502_abnormal_circadian_rhythm1.38433160
52MP0003436_decreased_susceptibility_to1.37975355
53MP0003646_muscle_fatigue1.37920363
54MP0000685_abnormal_immune_system1.36383919
55MP0002452_abnormal_antigen_presenting1.34885462
56MP0010678_abnormal_skin_adnexa1.34129883
57MP0003303_peritoneal_inflammation1.32156880
58MP0001324_abnormal_eye_pigmentation1.31046835
59* MP0000689_abnormal_spleen_morphology1.29750813
60MP0004742_abnormal_vestibular_system1.27614916
61MP0004883_abnormal_blood_vessel1.25167556
62MP0004885_abnormal_endolymph1.24716722
63MP0002405_respiratory_system_inflammati1.22237101
64MP0000716_abnormal_immune_system1.18972767
65MP0001984_abnormal_olfaction1.18472617
66MP0005391_vision/eye_phenotype1.18123404
67MP0008057_abnormal_DNA_replication1.15384208
68MP0001986_abnormal_taste_sensitivity1.14992430
69MP0010094_abnormal_chromosome_stability1.14059709
70MP0005195_abnormal_posterior_eye1.14046044
71MP0002396_abnormal_hematopoietic_system1.13119374
72MP0003172_abnormal_lysosome_physiology1.12471815
73MP0006054_spinal_hemorrhage1.11272887
74MP0003690_abnormal_glial_cell1.10848813
75MP0002928_abnormal_bile_duct1.09941597
76* MP0002722_abnormal_immune_system1.09103387
77MP0005310_abnormal_salivary_gland1.09098529
78MP0002102_abnormal_ear_morphology1.09081387
79MP0005025_abnormal_response_to1.06953257
80MP0002638_abnormal_pupillary_reflex1.06375511
81MP0000465_gastrointestinal_hemorrhage1.05671062
82MP0005387_immune_system_phenotype1.04973667
83MP0001790_abnormal_immune_system1.04973667
84MP0009046_muscle_twitch1.04881606
85MP0003632_abnormal_nervous_system1.04547978
86MP0008438_abnormal_cutaneous_collagen1.04308806
87MP0009785_altered_susceptibility_to1.03692822
88MP0001177_atelectasis1.01910642
89MP0003866_abnormal_defecation1.01264284
90MP0002332_abnormal_exercise_endurance1.00376385
91MP0002075_abnormal_coat/hair_pigmentati0.98554303
92MP0005164_abnormal_response_to0.97159795
93MP0000778_abnormal_nervous_system0.96496120
94MP0000703_abnormal_thymus_morphology0.95611418
95MP0008569_lethality_at_weaning0.95552246
96MP0001486_abnormal_startle_reflex0.95205039
97MP0000015_abnormal_ear_pigmentation0.94278354
98MP0003635_abnormal_synaptic_transmissio0.93381799
99MP0001851_eye_inflammation0.93061866
100MP0002095_abnormal_skin_pigmentation0.92507700
101MP0002168_other_aberrant_phenotype0.92240021
102MP0003221_abnormal_cardiomyocyte_apopto0.90120588
103MP0001346_abnormal_lacrimal_gland0.89947076
104MP0002254_reproductive_system_inflammat0.88833975
105MP0008260_abnormal_autophagy0.88629000
106MP0001919_abnormal_reproductive_system0.88419347
107MP0002163_abnormal_gland_morphology0.88180598
108MP0003943_abnormal_hepatobiliary_system0.87908266
109MP0000383_abnormal_hair_follicle0.87812768
110MP0000428_abnormal_craniofacial_morphol0.86759570
111MP0003705_abnormal_hypodermis_morpholog0.86643808
112MP0005671_abnormal_response_to0.85066957
113MP0003385_abnormal_body_wall0.84513724
114MP0003937_abnormal_limbs/digits/tail_de0.83958181
115MP0003880_abnormal_central_pattern0.83272218
116MP0002925_abnormal_cardiovascular_devel0.82481090
117MP0001845_abnormal_inflammatory_respons0.82373252
118MP0003453_abnormal_keratinocyte_physiol0.82006458
119MP0001915_intracranial_hemorrhage0.81924038
120MP0002429_abnormal_blood_cell0.81600898
121MP0002272_abnormal_nervous_system0.81465610
122MP0003183_abnormal_peptide_metabolism0.81036541
123MP0009115_abnormal_fat_cell0.80764265
124MP0002092_abnormal_eye_morphology0.80424830
125MP0005266_abnormal_metabolism0.80338501
126MP0009384_cardiac_valve_regurgitation0.80259641
127MP0002398_abnormal_bone_marrow0.79471966
128MP0005423_abnormal_somatic_nervous0.78688918
129MP0002064_seizures0.77821684
130MP0004134_abnormal_chest_morphology0.76712130
131MP0009703_decreased_birth_body0.76696576
132MP0003935_abnormal_craniofacial_develop0.76626572
133MP0002693_abnormal_pancreas_physiology0.76544422
134MP0001800_abnormal_humoral_immune0.76524708
135MP0004924_abnormal_behavior0.76227287
136MP0005386_behavior/neurological_phenoty0.76227287
137MP0000427_abnormal_hair_cycle0.76074984
138MP0004947_skin_inflammation0.75496813
139MP0002229_neurodegeneration0.74747998
140MP0001186_pigmentation_phenotype0.74667868
141MP0003279_aneurysm0.74043512
142MP0002882_abnormal_neuron_morphology0.73988964
143MP0003634_abnormal_glial_cell0.73190183
144MP0003633_abnormal_nervous_system0.73047440
145MP0008961_abnormal_basal_metabolism0.72675636
146MP0002138_abnormal_hepatobiliary_system0.72657131
147MP0004043_abnormal_pH_regulation0.72440957
148MP0004510_myositis0.72436568
149MP0005376_homeostasis/metabolism_phenot0.72326054
150MP0005621_abnormal_cell_physiology0.71442839
151MP0005647_abnormal_sex_gland0.71424751
152MP0003868_abnormal_feces_composition0.71321974
153MP0001293_anophthalmia0.70269851
154MP0002063_abnormal_learning/memory/cond0.70200050
155MP0008995_early_reproductive_senescence0.69563477
156MP0009764_decreased_sensitivity_to0.69188178
157MP0004142_abnormal_muscle_tone0.68477613
158MP0001545_abnormal_hematopoietic_system0.68354954
159MP0005397_hematopoietic_system_phenotyp0.68354954
160MP0004084_abnormal_cardiac_muscle0.67867114
161MP0005379_endocrine/exocrine_gland_phen0.66413731
162MP0005389_reproductive_system_phenotype0.66317175
163MP0001501_abnormal_sleep_pattern0.65777029
164MP0005646_abnormal_pituitary_gland0.65282698

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.63540876
2Hyperventilation (HP:0002883)3.74818555
3Abnormality of the fingertips (HP:0001211)3.50847591
4Stomatitis (HP:0010280)3.34913144
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.24310535
6Neoplasm of the tracheobronchial system (HP:0100552)3.15077456
7Retrobulbar optic neuritis (HP:0100654)3.08939354
8Optic neuritis (HP:0100653)3.08939354
9Fair hair (HP:0002286)2.97961782
10Macroorchidism (HP:0000053)2.84632825
11Recurrent bacterial skin infections (HP:0005406)2.82614419
12Volvulus (HP:0002580)2.78568972
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.68376311
14Submucous cleft hard palate (HP:0000176)2.66141484
15Long eyelashes (HP:0000527)2.64878965
16Orchitis (HP:0100796)2.64286203
17Recurrent fungal infections (HP:0002841)2.62554429
18Alveolar cell carcinoma (HP:0006519)2.58519729
19Eczematoid dermatitis (HP:0000976)2.55484816
20Myositis (HP:0100614)2.54227828
21Aortic aneurysm (HP:0004942)2.53814721
22Absent frontal sinuses (HP:0002688)2.53326696
23Central scotoma (HP:0000603)2.51288725
24Narrow palate (HP:0000189)2.51033769
25Thyroid carcinoma (HP:0002890)2.49910362
26T lymphocytopenia (HP:0005403)2.49664317
27Abnormality of the renal cortex (HP:0011035)2.47724467
28Subacute progressive viral hepatitis (HP:0006572)2.44798698
29Heterotopia (HP:0002282)2.43438181
30Recurrent cutaneous fungal infections (HP:0011370)2.41341510
31Chronic mucocutaneous candidiasis (HP:0002728)2.41341510
32Papillary thyroid carcinoma (HP:0002895)2.40887068
33Acute myeloid leukemia (HP:0004808)2.38225361
34Abnormality of T cells (HP:0002843)2.37426044
35Blue irides (HP:0000635)2.36205438
36Recurrent abscess formation (HP:0002722)2.35945642
37Aqueductal stenosis (HP:0002410)2.34600672
38Abnormality of T cell number (HP:0011839)2.34391609
39Curly hair (HP:0002212)2.34095173
40Febrile seizures (HP:0002373)2.31963821
41Protruding tongue (HP:0010808)2.31400210
42Hematochezia (HP:0002573)2.30863929
43Leukocytosis (HP:0001974)2.29568020
44Abnormality of eosinophils (HP:0001879)2.27274173
45Abnormality of the nasal septum (HP:0000419)2.26074727
46Short 4th metacarpal (HP:0010044)2.25837868
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.25837868
48Eosinophilia (HP:0001880)2.24474610
49Keratoconjunctivitis sicca (HP:0001097)2.24096051
50Absent speech (HP:0001344)2.23544504
51Keratoconjunctivitis (HP:0001096)2.17818793
52Arterial tortuosity (HP:0005116)2.16564513
53Gastrointestinal infarctions (HP:0005244)2.15215526
54Viral hepatitis (HP:0006562)2.15200564
55Hypochromic microcytic anemia (HP:0004840)2.11855586
56Vascular tortuosity (HP:0004948)2.11317048
57Elevated erythrocyte sedimentation rate (HP:0003565)2.10575607
58Ectopic kidney (HP:0000086)2.09550896
59Thyroiditis (HP:0100646)2.08358616
60Hypopigmentation of the fundus (HP:0007894)2.08039457
61Oligodactyly (hands) (HP:0001180)2.07342209
62Cerebral aneurysm (HP:0004944)2.05835608
63Short chin (HP:0000331)2.05348883
64Recurrent skin infections (HP:0001581)2.02732702
65Autoimmune hemolytic anemia (HP:0001890)2.01368879
66Widely spaced teeth (HP:0000687)2.00961014
67Neoplasm of the adrenal cortex (HP:0100641)2.00220179
68Spontaneous hematomas (HP:0007420)1.99487282
69Abnormality of macular pigmentation (HP:0008002)1.98125569
70Aplasia/Hypoplasia of the macula (HP:0008059)1.97956610
71Truncal obesity (HP:0001956)1.96712483
72Arterial thrombosis (HP:0004420)1.95524088
73Depressed nasal tip (HP:0000437)1.94779668
74Chest pain (HP:0100749)1.94264558
75Postural instability (HP:0002172)1.93791467
76Open mouth (HP:0000194)1.93090961
77Abnormality of the astrocytes (HP:0100707)1.92210146
78Astrocytoma (HP:0009592)1.92210146
79Gingival bleeding (HP:0000225)1.91990020
80Tented upper lip vermilion (HP:0010804)1.90803951
81Trigonocephaly (HP:0000243)1.90653275
82Abnormality of T cell physiology (HP:0011840)1.90618437
83Difficulty running (HP:0009046)1.89750796
84Episodic fever (HP:0001954)1.89056544
85Vertebral arch anomaly (HP:0008438)1.87080852
86Obsessive-compulsive behavior (HP:0000722)1.86744557
87Transitional cell carcinoma of the bladder (HP:0006740)1.86295861
88Abnormality of chromosome stability (HP:0003220)1.84749735
89Dyschromatopsia (HP:0007641)1.84714166
90Cone-rod dystrophy (HP:0000548)1.84333718
91Drooling (HP:0002307)1.84258568
92Excessive salivation (HP:0003781)1.84258568
93Urethral obstruction (HP:0000796)1.82994957
94Sandal gap (HP:0001852)1.82925573
95Pancreatic cysts (HP:0001737)1.82842457
96Severe combined immunodeficiency (HP:0004430)1.82728099
97Neoplasm of the oral cavity (HP:0100649)1.81787014
98Progressive inability to walk (HP:0002505)1.81474304
99Spondylolisthesis (HP:0003302)1.80897337
100Hypoplastic labia majora (HP:0000059)1.80268302
101Encephalitis (HP:0002383)1.79028985
102Pulmonary infiltrates (HP:0002113)1.77104786
103Bowel diverticulosis (HP:0005222)1.76773828
104Recurrent bronchitis (HP:0002837)1.76611923
105Limited elbow extension (HP:0001377)1.76464445
106Chronic hepatic failure (HP:0100626)1.76181636
107Pancreatic fibrosis (HP:0100732)1.76078246
108Broad-based gait (HP:0002136)1.75468499
109Aplasia/Hypoplasia affecting the retina (HP:0008061)1.74823991
110Prolonged bleeding time (HP:0003010)1.74116063
111Syringomyelia (HP:0003396)1.73853044
112Spinal cord lesions (HP:0100561)1.73853044
113Granulocytopenia (HP:0001913)1.73674734
114Shallow orbits (HP:0000586)1.73662260
115Prominent nose (HP:0000448)1.73517206
116Bony spicule pigmentary retinopathy (HP:0007737)1.73042323
117Congenital sensorineural hearing impairment (HP:0008527)1.72269005
118Lip pit (HP:0100267)1.72156072
119Hemoptysis (HP:0002105)1.71427382
120Scotoma (HP:0000575)1.71315896
121Scanning speech (HP:0002168)1.71279687
122Mitral valve prolapse (HP:0001634)1.70693973
123Large earlobe (HP:0009748)1.70224212
124Thick eyebrow (HP:0000574)1.69157557
125Aortic dissection (HP:0002647)1.68788310
126Deep philtrum (HP:0002002)1.68680407
127Recurrent viral infections (HP:0004429)1.68472384
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68003867
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.68003867
130Hip dysplasia (HP:0001385)1.67727677
131Vasculitis (HP:0002633)1.67402556
132Mediastinal lymphadenopathy (HP:0100721)1.67395593
133Gingivitis (HP:0000230)1.67098607
134Atonic seizures (HP:0010819)1.67046727
135Dilatation of the ascending aorta (HP:0005111)1.65265051
136Hamartoma of the eye (HP:0010568)1.64643519
137Focal seizures (HP:0007359)1.63409052
138Pigmentary retinal degeneration (HP:0001146)1.62580180
139Hypoplasia of the maxilla (HP:0000327)1.62285985
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62182957
141Panhypogammaglobulinemia (HP:0003139)1.61350623
142Broad metatarsal (HP:0001783)1.61060899
143Hypoplastic iliac wings (HP:0002866)1.60926054
144Smooth philtrum (HP:0000319)1.60727838
145Midline defect of the nose (HP:0004122)1.59745549
146Progressive cerebellar ataxia (HP:0002073)1.59083434
147Uterine leiomyosarcoma (HP:0002891)1.58273519
148Leiomyosarcoma (HP:0100243)1.58273519
149Glioma (HP:0009733)1.58258865
150Abnormality of the labia majora (HP:0012881)1.58014228
151Relative macrocephaly (HP:0004482)1.57336225
152Abnormality of the labia minora (HP:0012880)1.56147060
153Bladder neoplasm (HP:0009725)1.56075936
154Bladder carcinoma (HP:0002862)1.56075936
155Action tremor (HP:0002345)1.55719697
156Hypoplasia of the thymus (HP:0000778)1.54625074
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.54466975
158Hypoplasia of the fovea (HP:0007750)1.54466975
159Gaze-evoked nystagmus (HP:0000640)1.54158357
160Abnormality of the corticospinal tract (HP:0002492)1.53977291
161Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.52966352
162Low anterior hairline (HP:0000294)1.50683296
163Generalized hypopigmentation of hair (HP:0011358)1.50110184
164Abnormality of incisor morphology (HP:0011063)1.49520750
165Stomach cancer (HP:0012126)1.49016790
166Abnormality of chromosome segregation (HP:0002916)1.48872961
167Cutis marmorata (HP:0000965)1.48500247
168Synophrys (HP:0000664)1.48345503
169Dysmetric saccades (HP:0000641)1.47303764
170Coarse hair (HP:0002208)1.47163466
171Genetic anticipation (HP:0003743)1.45859236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B2.88163864
2CDK122.70969413
3LATS12.57466817
4CAMK1D2.50413520
5TAOK32.43994651
6AKT32.42199949
7BRD42.35582326
8CAMK1G2.22325839
9MAP3K22.14828369
10FGFR22.14346933
11TNIK2.11581291
12EPHA32.10373554
13IRAK12.03820090
14FGFR31.91194389
15YES11.73233198
16TXK1.73010291
17MAP3K131.72558168
18NUAK11.69701758
19SGK31.69270674
20SGK21.67817498
21PRPF4B1.61078692
22BMPR1B1.58239789
23TYRO31.57102287
24TEC1.55050127
25JAK11.53675861
26MAP3K141.53455440
27RIPK41.50909637
28BMPR21.50555953
29PDGFRB1.50337424
30MELK1.40899895
31PINK11.37429688
32PIK3CG1.37365140
33PTK2B1.36548519
34WNK11.35470719
35BLK1.32306270
36SGK4941.28342609
37SGK2231.28342609
38FRK1.27956017
39EPHB11.27777786
40ERBB31.27121872
41JAK31.27000403
42IRAK41.24022116
43NEK61.22115330
44TRPM71.21804057
45PKN21.21320562
46ITK1.17398903
47BRSK21.16845621
48ICK1.12808708
49PAK61.11979673
50RIPK11.11227781
51MARK31.10062702
52PRKCH1.09611132
53CSK1.09346180
54MKNK21.08585126
55FES1.08267502
56CDK31.08159462
57OXSR11.07567993
58STK101.07281270
59CHUK1.04934852
60SIK31.04405428
61NTRK21.01989727
62WNK31.00775731
63GRK61.00197847
64MAP3K40.99848338
65MAP2K30.98463742
66FGFR10.98358502
67BTK0.98138680
68CSNK1A1L0.97557576
69PAK30.96443602
70FGFR40.95936743
71STK30.93672052
72TTN0.92260064
73PTK60.91659226
74CDK60.91649894
75CASK0.91586328
76TYK20.90491737
77SIK20.89065144
78CDK90.88204989
79MAPK70.86623605
80SYK0.86467984
81DMPK0.85877450
82MAP4K10.82719170
83SIK10.82667941
84IKBKE0.82125688
85PRKCQ0.81546543
86RAF10.80198318
87CAMKK20.79273031
88EPHA40.78882428
89SCYL20.75387477
90MAP3K100.75042859
91RET0.74521795
92MAP4K20.74338114
93MARK20.72020337
94BMX0.71390171
95TNK20.70974013
96MET0.69832073
97LYN0.68788863
98NTRK30.68636077
99PDGFRA0.68006016
100MTOR0.67385988
101TGFBR20.67360110
102MAPK130.67309124
103ZAP700.67057736
104* SGK10.66622088
105OBSCN0.66274014
106NLK0.65746484
107ATM0.64411212
108INSR0.63238408
109CSNK1D0.62672983
110PIM10.62324088
111ATR0.61999026
112PLK20.60939606
113CAMK40.60518692
114FGR0.60335803
115KSR10.60027318
116MAPK100.59806073
117DYRK1A0.56344379
118INSRR0.55252689
119FER0.53873605
120PRKAA20.53811299
121MAP3K70.53710868
122PKN10.53665586
123IKBKB0.53218674
124MAP2K40.52008263
125STK40.51973560
126GSK3B0.51877540
127ALK0.51653854
128CHEK10.51121227
129LCK0.50924055
130MAPK10.50876232
131JAK20.50262222
132MST1R0.50134925
133CDC70.49477009
134HCK0.49381759
135BCR0.49255209
136MAP3K60.49073941
137MAPK80.48745154
138STK390.47497658
139RPS6KA30.47424511
140STK110.46932456
141MAP3K10.46409120
142PTK20.45895875
143DAPK20.45589880
144FYN0.45532231
145HIPK20.45527350
146MAPK140.45311284
147CSNK1G10.45105189
148MKNK10.44603416
149IRAK20.44031105
150CAMKK10.43052845
151TRIM280.41405193
152ADRBK20.40742606
153EIF2AK30.40472375
154ADRBK10.38784884
155KIT0.38295115

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.00599786
2RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61262402
3Phosphatidylinositol signaling system_Homo sapiens_hsa040701.51354836
4T cell receptor signaling pathway_Homo sapiens_hsa046601.43849566
5Leishmaniasis_Homo sapiens_hsa051401.38071640
6Nicotine addiction_Homo sapiens_hsa050331.35596426
7Glutamatergic synapse_Homo sapiens_hsa047241.25200325
8MicroRNAs in cancer_Homo sapiens_hsa052061.23689039
9Morphine addiction_Homo sapiens_hsa050321.21472745
10Long-term potentiation_Homo sapiens_hsa047201.19879001
11Axon guidance_Homo sapiens_hsa043601.19769615
12Dorso-ventral axis formation_Homo sapiens_hsa043201.19177417
13Type II diabetes mellitus_Homo sapiens_hsa049301.18920329
14Circadian rhythm_Homo sapiens_hsa047101.17628770
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16069345
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15814482
17Chronic myeloid leukemia_Homo sapiens_hsa052201.15306263
18Circadian entrainment_Homo sapiens_hsa047131.14999974
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14867074
20Primary immunodeficiency_Homo sapiens_hsa053401.10749791
21Inositol phosphate metabolism_Homo sapiens_hsa005621.10662381
22GABAergic synapse_Homo sapiens_hsa047271.09728274
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.09215082
24Regulation of autophagy_Homo sapiens_hsa041401.08908369
25Platelet activation_Homo sapiens_hsa046111.08609445
26Long-term depression_Homo sapiens_hsa047301.08264283
27Renal cell carcinoma_Homo sapiens_hsa052111.07221891
28Pancreatic cancer_Homo sapiens_hsa052121.06266369
29Adherens junction_Homo sapiens_hsa045201.05715827
30Proteoglycans in cancer_Homo sapiens_hsa052051.05458839
31B cell receptor signaling pathway_Homo sapiens_hsa046621.05067045
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04172766
33ErbB signaling pathway_Homo sapiens_hsa040121.03265121
34Cholinergic synapse_Homo sapiens_hsa047251.03048225
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02805233
36Prostate cancer_Homo sapiens_hsa052151.01688966
37MAPK signaling pathway_Homo sapiens_hsa040101.01445025
38Osteoclast differentiation_Homo sapiens_hsa043801.00967303
39Tuberculosis_Homo sapiens_hsa051521.00823495
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.00801171
41FoxO signaling pathway_Homo sapiens_hsa040681.00456476
42Choline metabolism in cancer_Homo sapiens_hsa052310.99740015
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99360119
44Colorectal cancer_Homo sapiens_hsa052100.98536755
45Oxytocin signaling pathway_Homo sapiens_hsa049210.97467064
46Chemokine signaling pathway_Homo sapiens_hsa040620.97347502
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96817754
48Lysine degradation_Homo sapiens_hsa003100.96032345
49Salivary secretion_Homo sapiens_hsa049700.95571289
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94841109
51Legionellosis_Homo sapiens_hsa051340.94010817
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93920689
53Measles_Homo sapiens_hsa051620.93260231
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92863321
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.92666196
56* mTOR signaling pathway_Homo sapiens_hsa041500.91694494
57Insulin resistance_Homo sapiens_hsa049310.90364004
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89393063
59Hepatitis C_Homo sapiens_hsa051600.89331715
60Glioma_Homo sapiens_hsa052140.88917130
61TNF signaling pathway_Homo sapiens_hsa046680.88645969
62Small cell lung cancer_Homo sapiens_hsa052220.88357021
63Endometrial cancer_Homo sapiens_hsa052130.87997643
64ABC transporters_Homo sapiens_hsa020100.87664909
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87206674
66Nitrogen metabolism_Homo sapiens_hsa009100.87131883
67Focal adhesion_Homo sapiens_hsa045100.86047230
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85627075
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85178201
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84754622
71TGF-beta signaling pathway_Homo sapiens_hsa043500.84443079
72cAMP signaling pathway_Homo sapiens_hsa040240.84343637
73Renin secretion_Homo sapiens_hsa049240.84050802
74Dopaminergic synapse_Homo sapiens_hsa047280.83427835
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82423350
76Hepatitis B_Homo sapiens_hsa051610.80967939
77GnRH signaling pathway_Homo sapiens_hsa049120.80897622
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80472767
79Non-homologous end-joining_Homo sapiens_hsa034500.80439574
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79881190
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.78703088
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78251640
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77656036
84Hematopoietic cell lineage_Homo sapiens_hsa046400.77252766
85Non-small cell lung cancer_Homo sapiens_hsa052230.75907474
86Viral carcinogenesis_Homo sapiens_hsa052030.75387944
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75316677
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.74870161
89Toxoplasmosis_Homo sapiens_hsa051450.74574389
90Estrogen signaling pathway_Homo sapiens_hsa049150.74499390
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74317095
92Rap1 signaling pathway_Homo sapiens_hsa040150.74263755
93Ether lipid metabolism_Homo sapiens_hsa005650.74142614
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71664001
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70955915
96HTLV-I infection_Homo sapiens_hsa051660.70848914
97Herpes simplex infection_Homo sapiens_hsa051680.70806591
98Prolactin signaling pathway_Homo sapiens_hsa049170.70554087
99Systemic lupus erythematosus_Homo sapiens_hsa053220.70224715
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.70162859
101Graft-versus-host disease_Homo sapiens_hsa053320.69790346
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69582217
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.69197399
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68903235
105Influenza A_Homo sapiens_hsa051640.68878724
106Ras signaling pathway_Homo sapiens_hsa040140.68594855
107Alcoholism_Homo sapiens_hsa050340.68072242
108Serotonergic synapse_Homo sapiens_hsa047260.66560255
109ECM-receptor interaction_Homo sapiens_hsa045120.66333159
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65881659
111Staphylococcus aureus infection_Homo sapiens_hsa051500.65411315
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.65133186
113Viral myocarditis_Homo sapiens_hsa054160.64754691
114Amphetamine addiction_Homo sapiens_hsa050310.64684544
115Olfactory transduction_Homo sapiens_hsa047400.64499518
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.64340980
117Melanoma_Homo sapiens_hsa052180.63254743
118Acute myeloid leukemia_Homo sapiens_hsa052210.63206333
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62888563
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62636548
121African trypanosomiasis_Homo sapiens_hsa051430.61795900
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61480905
123Malaria_Homo sapiens_hsa051440.60952210
124VEGF signaling pathway_Homo sapiens_hsa043700.60834789
125Taste transduction_Homo sapiens_hsa047420.60802799
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59877240
127Type I diabetes mellitus_Homo sapiens_hsa049400.59856355
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57380848
129Autoimmune thyroid disease_Homo sapiens_hsa053200.55416870
130Allograft rejection_Homo sapiens_hsa053300.54553174
131Calcium signaling pathway_Homo sapiens_hsa040200.53251406

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