RIF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.51964640
2nuclear pore organization (GO:0006999)6.30615616
3mitotic metaphase plate congression (GO:0007080)4.97192361
4pore complex assembly (GO:0046931)4.95471220
5protein localization to kinetochore (GO:0034501)4.75295470
6regulation of DNA endoreduplication (GO:0032875)4.61330002
7metaphase plate congression (GO:0051310)4.47757451
8DNA replication-dependent nucleosome assembly (GO:0006335)4.47684252
9DNA replication-dependent nucleosome organization (GO:0034723)4.47684252
10mitotic chromosome condensation (GO:0007076)4.47063868
11mitotic sister chromatid cohesion (GO:0007064)4.40119775
12regulation of histone H3-K9 methylation (GO:0051570)4.38991186
13mitotic nuclear envelope disassembly (GO:0007077)4.29544924
14DNA replication initiation (GO:0006270)4.27089988
15regulation of helicase activity (GO:0051095)4.26141394
16regulation of gene silencing by RNA (GO:0060966)4.21186900
17regulation of posttranscriptional gene silencing (GO:0060147)4.21186900
18regulation of gene silencing by miRNA (GO:0060964)4.21186900
19double-strand break repair via nonhomologous end joining (GO:0006303)4.17036471
20non-recombinational repair (GO:0000726)4.17036471
21negative regulation of histone methylation (GO:0031061)4.11462799
22kinetochore organization (GO:0051383)4.11426686
23chromatin remodeling at centromere (GO:0031055)4.09427138
24protein localization to chromosome, centromeric region (GO:0071459)4.08007302
25DNA unwinding involved in DNA replication (GO:0006268)4.03835870
26membrane disassembly (GO:0030397)4.03008225
27nuclear envelope disassembly (GO:0051081)4.03008225
28protein K6-linked ubiquitination (GO:0085020)4.02793365
29regulation of spindle organization (GO:0090224)4.02033932
30regulation of centriole replication (GO:0046599)3.94260506
31DNA replication checkpoint (GO:0000076)3.90905224
32CENP-A containing nucleosome assembly (GO:0034080)3.86280181
33regulation of RNA export from nucleus (GO:0046831)3.85992107
34replication fork processing (GO:0031297)3.85603150
35meiotic chromosome segregation (GO:0045132)3.85545684
36mitotic sister chromatid segregation (GO:0000070)3.84162815
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.83403327
38DNA replication-independent nucleosome assembly (GO:0006336)3.79769771
39DNA replication-independent nucleosome organization (GO:0034724)3.79769771
40sister chromatid segregation (GO:0000819)3.77060967
41establishment of chromosome localization (GO:0051303)3.76176864
42positive regulation of chromosome segregation (GO:0051984)3.75756750
43regulation of mitotic spindle organization (GO:0060236)3.72829406
44histone exchange (GO:0043486)3.70911163
45synapsis (GO:0007129)3.67786487
46DNA double-strand break processing (GO:0000729)3.66527369
47nucleobase biosynthetic process (GO:0046112)3.66368545
48attachment of spindle microtubules to kinetochore (GO:0008608)3.66097517
49DNA geometric change (GO:0032392)3.64234908
50DNA duplex unwinding (GO:0032508)3.64114759
51pre-miRNA processing (GO:0031054)3.62729763
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62013078
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62013078
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.62013078
55regulation of centrosome cycle (GO:0046605)3.62010626
56histone H2A monoubiquitination (GO:0035518)3.60857427
57IMP biosynthetic process (GO:0006188)3.57658322
58somatic hypermutation of immunoglobulin genes (GO:0016446)3.57437787
59somatic diversification of immune receptors via somatic mutation (GO:0002566)3.57437787
60resolution of meiotic recombination intermediates (GO:0000712)3.55913633
61regulation of sister chromatid cohesion (GO:0007063)3.55461872
62DNA strand elongation involved in DNA replication (GO:0006271)3.54175619
63folic acid-containing compound biosynthetic process (GO:0009396)3.51346485
64ribosome assembly (GO:0042255)3.50607067
65purine nucleobase biosynthetic process (GO:0009113)3.48967009
66DNA topological change (GO:0006265)3.46988098
67kinetochore assembly (GO:0051382)3.46676763
68mitotic G2/M transition checkpoint (GO:0044818)3.46589644
69chromatin assembly or disassembly (GO:0006333)3.44910513
70regulation of chromosome segregation (GO:0051983)3.43943904
71spindle checkpoint (GO:0031577)3.40843412
72negative regulation of DNA recombination (GO:0045910)3.39591825
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38298744
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.38065805
75DNA strand elongation (GO:0022616)3.37403685
76negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35276547
77negative regulation of translation, ncRNA-mediated (GO:0040033)3.35276547
78regulation of translation, ncRNA-mediated (GO:0045974)3.35276547
79chromatin assembly (GO:0031497)3.34493031
80translesion synthesis (GO:0019985)3.33712773
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.33238863
82postreplication repair (GO:0006301)3.33163868
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32255781
84regulation of mitotic spindle checkpoint (GO:1903504)3.32255781
85regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32102172
86dosage compensation (GO:0007549)3.31723674
87mitotic recombination (GO:0006312)3.29996086
88negative regulation of DNA-dependent DNA replication (GO:2000104)3.29343243
89protein localization to chromosome (GO:0034502)3.29151450
90sister chromatid cohesion (GO:0007062)3.26745016
91monoubiquitinated protein deubiquitination (GO:0035520)3.25880869
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25624207
93negative regulation of chromosome segregation (GO:0051985)3.23146940
94telomere maintenance via semi-conservative replication (GO:0032201)3.22854578
95chromosome segregation (GO:0007059)3.22159084
96IMP metabolic process (GO:0046040)3.21656562
97heterochromatin organization (GO:0070828)3.20465651
98telomere maintenance via recombination (GO:0000722)3.20405712
99spindle assembly checkpoint (GO:0071173)3.20150614
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.19123095
101negative regulation of mitotic sister chromatid separation (GO:2000816)3.18363280
102negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18363280
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18363280
104negative regulation of sister chromatid segregation (GO:0033046)3.18363280
105regulation of mitotic sister chromatid separation (GO:0010965)3.18352040
106regulation of mitotic sister chromatid segregation (GO:0033047)3.18352040
107regulation of sister chromatid segregation (GO:0033045)3.18352040
108mitotic spindle checkpoint (GO:0071174)3.17670346
109regulation of gene silencing (GO:0060968)3.16900571
110mismatch repair (GO:0006298)3.15789987
111regulation of centrosome duplication (GO:0010824)3.12229805
112negative regulation of DNA repair (GO:0045738)3.10906694
113DNA conformation change (GO:0071103)3.10411336
114negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10384116
115mitotic spindle assembly checkpoint (GO:0007094)3.10275095
116ATP-dependent chromatin remodeling (GO:0043044)3.09580791
117nucleotide-excision repair, DNA gap filling (GO:0006297)3.08860198
118regulation of telomere maintenance via telomerase (GO:0032210)3.08107208
119positive regulation of histone H3-K4 methylation (GO:0051571)3.07759789
120histone-serine phosphorylation (GO:0035404)3.03816826
121centriole replication (GO:0007099)3.01677533
122DNA synthesis involved in DNA repair (GO:0000731)2.99669091
123microtubule anchoring (GO:0034453)2.98716147
124double-strand break repair via homologous recombination (GO:0000724)2.97153806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.34788690
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.45894510
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.61007136
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43159663
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.41955298
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.22637049
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87224711
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79167818
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69226352
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51012079
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.48136025
12AR_21909140_ChIP-Seq_LNCAP_Human2.41747805
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.40933347
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30800649
15FUS_26573619_Chip-Seq_HEK293_Human2.27582582
16* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.25246357
17EWS_26573619_Chip-Seq_HEK293_Human2.19355319
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15938991
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14569650
20* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12688631
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12181779
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.05151381
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.05151381
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.05151381
25* E2F7_22180533_ChIP-Seq_HELA_Human10.7123208
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97655142
27* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94528775
28* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92668459
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91766895
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.89938873
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88136508
32* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87747305
33* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.81001299
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80722426
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78688720
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77968695
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72632561
38TAF15_26573619_Chip-Seq_HEK293_Human1.70947907
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67642321
40* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.67023880
41XRN2_22483619_ChIP-Seq_HELA_Human1.66669620
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.65082790
43* VDR_23849224_ChIP-Seq_CD4+_Human1.64950736
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.62852389
45VDR_22108803_ChIP-Seq_LS180_Human1.59371411
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58360254
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.57765416
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55693600
49* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52429866
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51469411
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.50520918
52ZNF274_21170338_ChIP-Seq_K562_Hela1.48930926
53* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48141653
54GBX2_23144817_ChIP-Seq_PC3_Human1.48065401
55FOXP3_21729870_ChIP-Seq_TREG_Human1.46599119
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45153406
57* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.44971404
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44912671
59ELK1_19687146_ChIP-ChIP_HELA_Human1.44565402
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44512987
61* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43315769
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41907010
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40902877
64IGF1R_20145208_ChIP-Seq_DFB_Human1.40573240
65* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38923649
66P300_19829295_ChIP-Seq_ESCs_Human1.38440158
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38253374
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38098374
69KDM5A_27292631_Chip-Seq_BREAST_Human1.36364803
70TTF2_22483619_ChIP-Seq_HELA_Human1.33271884
71* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32092936
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30538994
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30129297
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29853631
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26485909
76* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25833049
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24924171
78* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24808708
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24723222
80* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24704521
81* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23868593
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22497388
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22212335
84CIITA_25753668_ChIP-Seq_RAJI_Human1.20271143
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.18601015
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17472120
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16162258
88* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15935624
89GABP_19822575_ChIP-Seq_HepG2_Human1.14066283
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13124681
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12969401
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.12677170
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.12582014
94STAT3_23295773_ChIP-Seq_U87_Human1.10996749
95MYC_22102868_ChIP-Seq_BL_Human1.10463939
96DCP1A_22483619_ChIP-Seq_HELA_Human1.10441683
97* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09618483
98* NANOG_16153702_ChIP-ChIP_HESCs_Human1.08713639
99SOX9_26525672_Chip-Seq_HEART_Mouse1.07637661
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05201184
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05098854
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04953147
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04939269
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04873121
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03666454
106* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02947841
107SMAD4_21799915_ChIP-Seq_A2780_Human1.02722149
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02434860
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01650688
110* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00562150
111* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00547866
112WT1_19549856_ChIP-ChIP_CCG9911_Human1.00330280
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00076625
114* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99468446
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99114160
116IRF1_19129219_ChIP-ChIP_H3396_Human0.98980576
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98600422
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98075954
119SMAD3_21741376_ChIP-Seq_EPCs_Human0.98030401
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97953811
121TCF4_23295773_ChIP-Seq_U87_Human0.97005210
122* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96612116
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96129054
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95484965
125TFEB_21752829_ChIP-Seq_HELA_Human0.94340549
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93907851
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93544212
128ER_23166858_ChIP-Seq_MCF-7_Human0.93528283
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92680227
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91775691
131CBP_20019798_ChIP-Seq_JUKART_Human0.91775691
132* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91456590
133MYC_18940864_ChIP-ChIP_HL60_Human0.91186992
134* NANOG_18555785_Chip-Seq_ESCs_Mouse0.90888320
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.90206977
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90165820
137* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89924175
138* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89647007
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87924162
140PIAS1_25552417_ChIP-Seq_VCAP_Human0.87169917
141* E2F1_18555785_Chip-Seq_ESCs_Mouse0.86783001
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85651575
143CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85587302
144* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84846964
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84521858
146* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.84085533
147* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83020502
148* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82485560
149TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82366496
150SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81813695
151* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81367716
152* SOX2_16153702_ChIP-ChIP_HESCs_Human0.81043535
153DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80852373
154* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79124373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.93485266
2MP0010094_abnormal_chromosome_stability4.82021801
3MP0003693_abnormal_embryo_hatching4.59005950
4MP0003111_abnormal_nucleus_morphology4.36765622
5MP0004957_abnormal_blastocyst_morpholog3.92728974
6* MP0003077_abnormal_cell_cycle3.77858131
7MP0008058_abnormal_DNA_repair3.35474370
8MP0008877_abnormal_DNA_methylation3.32953003
9MP0008007_abnormal_cellular_replicative2.83988172
10MP0003123_paternal_imprinting2.83429214
11MP0010307_abnormal_tumor_latency2.81952731
12MP0001730_embryonic_growth_arrest2.46528232
13MP0009697_abnormal_copulation2.37895196
14MP0010352_gastrointestinal_tract_polyps2.34867619
15* MP0000350_abnormal_cell_proliferation2.34442367
16MP0008932_abnormal_embryonic_tissue2.25331481
17MP0003121_genomic_imprinting2.12345687
18MP0005380_embryogenesis_phenotype2.03223574
19MP0001672_abnormal_embryogenesis/_devel2.03223574
20MP0002084_abnormal_developmental_patter2.01594570
21MP0003786_premature_aging2.00391188
22MP0001697_abnormal_embryo_size1.87700026
23MP0002085_abnormal_embryonic_tissue1.87458832
24MP0003890_abnormal_embryonic-extraembry1.85303411
25MP0003787_abnormal_imprinting1.82416482
26MP0004197_abnormal_fetal_growth/weight/1.79315920
27MP0003984_embryonic_growth_retardation1.74675692
28MP0002210_abnormal_sex_determination1.72848421
29MP0002088_abnormal_embryonic_growth/wei1.71403143
30MP0002086_abnormal_extraembryonic_tissu1.71183988
31MP0005076_abnormal_cell_differentiation1.70705268
32MP0003718_maternal_effect1.60382342
33MP0002396_abnormal_hematopoietic_system1.52637762
34* MP0002080_prenatal_lethality1.52242223
35MP0001929_abnormal_gametogenesis1.50568809
36MP0001145_abnormal_male_reproductive1.48351613
37MP0002653_abnormal_ependyma_morphology1.48018688
38MP0001293_anophthalmia1.46912185
39MP0003937_abnormal_limbs/digits/tail_de1.46432945
40MP0003941_abnormal_skin_development1.35924959
41MP0003567_abnormal_fetal_cardiomyocyte1.34553847
42MP0000653_abnormal_sex_gland1.32986896
43MP0006292_abnormal_olfactory_placode1.28665984
44MP0000313_abnormal_cell_death1.24653095
45MP0003119_abnormal_digestive_system1.23547554
46MP0009703_decreased_birth_body1.14725628
47MP0000383_abnormal_hair_follicle1.13840599
48MP0000490_abnormal_crypts_of1.12295411
49MP0003646_muscle_fatigue1.12031338
50MP0004147_increased_porphyrin_level1.11684149
51MP0005187_abnormal_penis_morphology1.11659435
52MP0003950_abnormal_plasma_membrane1.10286112
53MP0009672_abnormal_birth_weight1.07277681
54MP0002019_abnormal_tumor_incidence1.06997141
55MP0002938_white_spotting1.06387848
56MP0010234_abnormal_vibrissa_follicle1.05593364
57MP0003806_abnormal_nucleotide_metabolis1.05229433
58MP0001188_hyperpigmentation1.02796052
59MP0004808_abnormal_hematopoietic_stem1.02157542
60MP0000537_abnormal_urethra_morphology1.01656822
61MP0003315_abnormal_perineum_morphology1.01480669
62MP0002160_abnormal_reproductive_system1.00699415
63MP0003136_yellow_coat_color1.00697248
64MP0001119_abnormal_female_reproductive1.00317292
65MP0004133_heterotaxia1.00029976
66MP0003705_abnormal_hypodermis_morpholog0.98670307
67MP0010678_abnormal_skin_adnexa0.98066861
68MP0001299_abnormal_eye_distance/0.97517192
69MP0004264_abnormal_extraembryonic_tissu0.96712649
70MP0001286_abnormal_eye_development0.96623753
71MP0003698_abnormal_male_reproductive0.96229822
72MP0000432_abnormal_head_morphology0.94808160
73MP0000647_abnormal_sebaceous_gland0.93800518
74MP0002877_abnormal_melanocyte_morpholog0.93691974
75MP0001849_ear_inflammation0.93265769
76MP0009053_abnormal_anal_canal0.92631160
77MP0000427_abnormal_hair_cycle0.91813754
78MP0003221_abnormal_cardiomyocyte_apopto0.91092462
79MP0002111_abnormal_tail_morphology0.88739811
80MP0003385_abnormal_body_wall0.88646033
81MP0002092_abnormal_eye_morphology0.88077883
82MP0000516_abnormal_urinary_system0.84513774
83MP0005367_renal/urinary_system_phenotyp0.84513774
84MP0003861_abnormal_nervous_system0.83897404
85MP0000428_abnormal_craniofacial_morphol0.83852913
86MP0006035_abnormal_mitochondrial_morpho0.83749856
87MP0000778_abnormal_nervous_system0.83727354
88MP0003943_abnormal_hepatobiliary_system0.82732966
89MP0005389_reproductive_system_phenotype0.82713100
90MP0005391_vision/eye_phenotype0.81799416
91MP0001177_atelectasis0.80737810
92MP0000631_abnormal_neuroendocrine_gland0.80381417
93MP0008995_early_reproductive_senescence0.79580043
94MP0002697_abnormal_eye_size0.79545742
95MP0010030_abnormal_orbit_morphology0.78821559
96MP0005621_abnormal_cell_physiology0.77204108
97MP0005395_other_phenotype0.76329437
98MP0003936_abnormal_reproductive_system0.76246482
99MP0003699_abnormal_female_reproductive0.75473792
100MP0005384_cellular_phenotype0.75012999
101MP0003935_abnormal_craniofacial_develop0.74058810
102MP0003755_abnormal_palate_morphology0.73565657
103MP0002009_preneoplasia0.73349405
104MP0005253_abnormal_eye_physiology0.73302660
105* MP0002161_abnormal_fertility/fecundity0.72242187
106MP0001915_intracranial_hemorrhage0.72062854
107MP0002751_abnormal_autonomic_nervous0.71924537
108MP0000703_abnormal_thymus_morphology0.67608142
109MP0002925_abnormal_cardiovascular_devel0.67059730
110MP0002081_perinatal_lethality0.66007385
111MP0000358_abnormal_cell_content/0.65527261
112MP0002095_abnormal_skin_pigmentation0.63963193
113MP0003566_abnormal_cell_adhesion0.63322447
114MP0006072_abnormal_retinal_apoptosis0.63140381
115MP0002233_abnormal_nose_morphology0.63006169
116MP0005248_abnormal_Harderian_gland0.61461700
117MP0000569_abnormal_digit_pigmentation0.60479566
118MP0001984_abnormal_olfaction0.59841025
119MP0003115_abnormal_respiratory_system0.59339061
120MP0002114_abnormal_axial_skeleton0.58949567
121MP0000627_abnormal_mammary_gland0.58618146
122MP0002109_abnormal_limb_morphology0.58377587
123MP0004134_abnormal_chest_morphology0.57977790
124MP0004215_abnormal_myocardial_fiber0.57548373
125MP0002102_abnormal_ear_morphology0.56922368
126MP0005397_hematopoietic_system_phenotyp0.56885833
127MP0001545_abnormal_hematopoietic_system0.56885833
128MP0004185_abnormal_adipocyte_glucose0.56482196
129MP0002075_abnormal_coat/hair_pigmentati0.56385811
130MP0005023_abnormal_wound_healing0.54438633
131MP0008770_decreased_survivor_rate0.54316153

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.07552398
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.80999877
3Abnormality of the labia minora (HP:0012880)4.40401615
4Birth length less than 3rd percentile (HP:0003561)4.28744274
5Ependymoma (HP:0002888)4.23905917
6Abnormality of chromosome stability (HP:0003220)3.96892333
7Medulloblastoma (HP:0002885)3.78076187
8Impulsivity (HP:0100710)3.37314667
9Meckel diverticulum (HP:0002245)3.34128804
10Supernumerary spleens (HP:0009799)3.33075343
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.31794280
12Neoplasm of the oral cavity (HP:0100649)3.31762856
13Abnormality of the preputium (HP:0100587)3.29898620
14Colon cancer (HP:0003003)3.28192007
15Volvulus (HP:0002580)3.23826493
16Abnormality of the astrocytes (HP:0100707)3.19568888
17Astrocytoma (HP:0009592)3.19568888
18Breast hypoplasia (HP:0003187)3.15053391
19Abnormality of the ileum (HP:0001549)3.13594029
20Agnosia (HP:0010524)3.08028228
21Rhabdomyosarcoma (HP:0002859)3.06877885
22Absent radius (HP:0003974)3.06042716
23Ectopic kidney (HP:0000086)3.00119758
24Patellar aplasia (HP:0006443)2.94569594
25Aplasia involving forearm bones (HP:0009822)2.90276138
26Absent forearm bone (HP:0003953)2.90276138
27Glioma (HP:0009733)2.88353810
28Biliary tract neoplasm (HP:0100574)2.80897520
29Myelodysplasia (HP:0002863)2.74485197
30Duodenal stenosis (HP:0100867)2.72250007
31Small intestinal stenosis (HP:0012848)2.72250007
32Selective tooth agenesis (HP:0001592)2.71610398
33Aplasia/Hypoplasia of the patella (HP:0006498)2.69107179
34Shawl scrotum (HP:0000049)2.60124977
35Facial hemangioma (HP:0000329)2.59025404
36Sloping forehead (HP:0000340)2.53516557
37Nephroblastoma (Wilms tumor) (HP:0002667)2.45742930
38Abnormality of the carotid arteries (HP:0005344)2.44168926
39Proximal placement of thumb (HP:0009623)2.42918483
40Aplasia/Hypoplasia of the sternum (HP:0006714)2.41959077
41Deviation of the thumb (HP:0009603)2.40706059
42Cafe-au-lait spot (HP:0000957)2.39715449
43Abnormality of the duodenum (HP:0002246)2.38538995
44Absent thumb (HP:0009777)2.37872088
45Papillary thyroid carcinoma (HP:0002895)2.36347851
46Short thumb (HP:0009778)2.33784956
47Neoplasm of striated muscle (HP:0009728)2.33782626
48Prominent nose (HP:0000448)2.33297235
49Missing ribs (HP:0000921)2.32734851
50Aplasia/hypoplasia of the humerus (HP:0006507)2.31648521
51Embryonal renal neoplasm (HP:0011794)2.26094234
52Sandal gap (HP:0001852)2.25980598
53Cortical dysplasia (HP:0002539)2.25278217
54Oligodactyly (hands) (HP:0001180)2.25240392
5511 pairs of ribs (HP:0000878)2.22857761
56Short humerus (HP:0005792)2.20792848
57Amaurosis fugax (HP:0100576)2.20557922
58Increased nuchal translucency (HP:0010880)2.19941166
59Neoplasm of the pancreas (HP:0002894)2.19741811
60Esophageal atresia (HP:0002032)2.19143270
61Basal cell carcinoma (HP:0002671)2.18067438
62Carpal bone hypoplasia (HP:0001498)2.16485161
63Rib fusion (HP:0000902)2.15047999
64Bifid tongue (HP:0010297)2.12925849
65Bone marrow hypocellularity (HP:0005528)2.08540945
66Reticulocytopenia (HP:0001896)2.08211697
67Acute myeloid leukemia (HP:0004808)2.07356473
68Duplicated collecting system (HP:0000081)2.06189866
69Anal stenosis (HP:0002025)2.05537697
70Gastrointestinal carcinoma (HP:0002672)2.05447803
71Malignant gastrointestinal tract tumors (HP:0006749)2.05447803
72Abnormal biliary tract morphology (HP:0012440)2.03968335
73Embryonal neoplasm (HP:0002898)2.03273793
74Arteriovenous malformation (HP:0100026)2.03048220
75Oligodactyly (HP:0012165)2.02504989
76Clubbing of toes (HP:0100760)2.02172183
77Degeneration of anterior horn cells (HP:0002398)2.01870267
78Abnormality of the anterior horn cell (HP:0006802)2.01870267
79Abnormality of the fingertips (HP:0001211)2.00802059
80Horseshoe kidney (HP:0000085)2.00745472
81Tracheoesophageal fistula (HP:0002575)2.00608346
82Abnormal number of incisors (HP:0011064)1.97862004
83Oral leukoplakia (HP:0002745)1.96604584
84Long clavicles (HP:0000890)1.95290010
85Abnormality of abdominal situs (HP:0011620)1.94468051
86Abdominal situs inversus (HP:0003363)1.94468051
87Overlapping toe (HP:0001845)1.93526277
88Acute lymphatic leukemia (HP:0006721)1.93080600
89Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.92702120
90Short 1st metacarpal (HP:0010034)1.92702120
91Abnormal lung lobation (HP:0002101)1.91556470
92Long eyelashes (HP:0000527)1.90307284
93Neoplasm of the colon (HP:0100273)1.87440439
94Thyroid carcinoma (HP:0002890)1.85693700
95Intestinal atresia (HP:0011100)1.84342104
96Protruding tongue (HP:0010808)1.84099945
97Breast aplasia (HP:0100783)1.84086578
98Triphalangeal thumb (HP:0001199)1.83352930
99Supernumerary bones of the axial skeleton (HP:0009144)1.82211693
100Hepatoblastoma (HP:0002884)1.82128617
101Hypoplastic labia majora (HP:0000059)1.80487738
102Gastrointestinal atresia (HP:0002589)1.80413460
103Supernumerary ribs (HP:0005815)1.80221675
104Abnormality of the renal collecting system (HP:0004742)1.80059767
105Sparse lateral eyebrow (HP:0005338)1.78786596
106Atresia of the external auditory canal (HP:0000413)1.78155070
107Ovarian neoplasm (HP:0100615)1.77996011
108Abnormality of chromosome segregation (HP:0002916)1.77257847
109Cystic hygroma (HP:0000476)1.76564731
110Neoplasm of the adrenal cortex (HP:0100641)1.76554832
111Aqueductal stenosis (HP:0002410)1.76490622
112Abnormal spermatogenesis (HP:0008669)1.76319528
113Abnormality of DNA repair (HP:0003254)1.76143436
114Neoplasm of the small intestine (HP:0100833)1.75364380
115Aplasia/Hypoplasia of the earlobes (HP:0009906)1.75351595
116Choanal atresia (HP:0000453)1.75231935
117Heterotopia (HP:0002282)1.74791563
118Abnormality of cochlea (HP:0000375)1.73865410
119Clitoromegaly (HP:0000057)1.71150869
120Abnormality of the labia majora (HP:0012881)1.70097119
121Pancreatic islet-cell hyperplasia (HP:0004510)1.67005716
122Small hand (HP:0200055)1.66144965
123Deep philtrum (HP:0002002)1.65704872
124Abnormality of the septum pellucidum (HP:0007375)1.64071977
125Astigmatism (HP:0000483)1.63609563
126Obsessive-compulsive behavior (HP:0000722)1.63568696
127Skull defect (HP:0001362)1.63377814
128Truncal obesity (HP:0001956)1.60843908
129Cutaneous finger syndactyly (HP:0010554)1.60833398
130Breast carcinoma (HP:0003002)1.57498015
131Facial cleft (HP:0002006)1.56507103
132Septo-optic dysplasia (HP:0100842)1.56259108
133Abnormal hair whorl (HP:0010721)1.55943302
134Fair hair (HP:0002286)1.54374498
135Cupped ear (HP:0000378)1.52632709
136Blepharophimosis (HP:0000581)1.49962981
137Midline defect of the nose (HP:0004122)1.48830300
138Low anterior hairline (HP:0000294)1.47967222
139Partial agenesis of the corpus callosum (HP:0001338)1.47070389
140Microtia (HP:0008551)1.46237447
141Absent eyebrow (HP:0002223)1.45697692
142Cutaneous syndactyly (HP:0012725)1.44635765
143Drooling (HP:0002307)1.43675284
144Gonadotropin excess (HP:0000837)1.42925719
145Chronic hepatic failure (HP:0100626)1.42457831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.04631189
2WEE14.14964721
3CDK123.65690568
4SRPK13.17869357
5TTK2.96411542
6NEK22.94274934
7BUB12.68414834
8LATS12.58911039
9PNCK2.21838824
10PLK12.15254217
11CHEK22.02051028
12PLK31.99534241
13TAF11.97868768
14BRSK21.97349905
15STK38L1.96973118
16ATR1.94329939
17EPHA21.93772989
18NEK11.90685127
19ACVR1B1.90404605
20MKNK21.90344992
21PLK41.89987531
22BMPR1B1.83015803
23TSSK61.78838201
24MKNK11.75773313
25TNIK1.75328380
26EIF2AK11.70599383
27TLK11.68064090
28BRD41.65346580
29* CHEK11.64258630
30CDK71.62982899
31PASK1.62636697
32RPS6KB21.62112404
33* AURKB1.61069216
34LATS21.54914862
35MAP3K41.53389772
36DYRK31.52130323
37ZAK1.52041039
38* ATM1.43682568
39VRK11.42832969
40CASK1.41886403
41STK31.38058082
42CDK41.37668263
43CAMK1G1.25070838
44EEF2K1.22880431
45STK41.22361778
46MAP3K81.17800014
47MAP3K101.16971981
48EIF2AK31.16318934
49CDK21.15833718
50MAP3K91.15627337
51SCYL21.14060672
52ALK1.10893526
53ERBB31.08465388
54MELK1.08403476
55OBSCN1.07608948
56AKT30.96860538
57CDK10.94984801
58STK390.94424997
59CDK60.92777662
60AURKA0.92689957
61STK100.90933092
62PDK30.88227293
63PDK40.88227293
64TRIM280.86490639
65CSNK1D0.85256861
66PIM10.85129830
67RPS6KA40.84876308
68NLK0.82811888
69PLK20.82177147
70BRSK10.82094512
71CCNB10.73157650
72MTOR0.73026697
73CDK90.67892361
74FLT30.66995305
75PRKDC0.66712567
76CSNK2A20.65764589
77CSNK1E0.65618232
78SGK20.64158774
79CLK10.62449112
80RPS6KA50.60176853
81ERBB40.58080557
82FGFR20.57031280
83WNK30.56560191
84MAPK140.56080858
85PDK20.55303619
86FRK0.54679217
87OXSR10.53489952
88PKN20.52609843
89KSR10.51780655
90MST40.50888686
91TGFBR10.50474987
92WNK10.50258550
93RAF10.48437926
94EPHA40.48350021
95PRKCI0.47555843
96GSK3B0.45120787
97TEC0.45061912
98CSNK2A10.45048503
99EIF2AK20.44843917
100NUAK10.44812568
101DMPK0.41247446
102MAPK100.40481495
103SGK10.40466389
104AKT10.39264550
105MAP2K70.38779953
106CAMK1D0.38114260
107MAP3K60.38030485
108MAPK10.36591858
109STK240.36421616
110MET0.36307580
111WNK40.35729192
112TESK20.35150133
113CDK30.34890533
114AKT20.34038680
115PRKACB0.32538850
116FGFR10.32025427
117PAK40.30750120
118NEK60.30533085
119STK380.30127604
120MARK30.27996190
121PAK20.26087926
122CDK80.25486648
123BRAF0.25244269
124PAK10.23960176
125RPS6KB10.23793145
126YES10.23543936
127CSNK1G10.23321397
128BCR0.21599351
129CHUK0.19821271
130TYRO30.18396569
131PBK0.18357648

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.42674656
2DNA replication_Homo sapiens_hsa030304.28744837
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.18173354
4RNA transport_Homo sapiens_hsa030133.51218615
5Cell cycle_Homo sapiens_hsa041103.35052908
6Homologous recombination_Homo sapiens_hsa034403.26769532
7Fanconi anemia pathway_Homo sapiens_hsa034603.13532343
8Spliceosome_Homo sapiens_hsa030403.09481786
9One carbon pool by folate_Homo sapiens_hsa006702.97276305
10RNA polymerase_Homo sapiens_hsa030202.88863320
11Nucleotide excision repair_Homo sapiens_hsa034202.87669955
12Non-homologous end-joining_Homo sapiens_hsa034502.74821378
13Basal transcription factors_Homo sapiens_hsa030222.51566605
14mRNA surveillance pathway_Homo sapiens_hsa030152.42588522
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41401414
16Base excision repair_Homo sapiens_hsa034102.39342816
17RNA degradation_Homo sapiens_hsa030182.38421926
18Systemic lupus erythematosus_Homo sapiens_hsa053222.15212201
19p53 signaling pathway_Homo sapiens_hsa041151.91715573
20Pyrimidine metabolism_Homo sapiens_hsa002401.88681574
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66189011
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45671302
23Oocyte meiosis_Homo sapiens_hsa041141.38378591
24Viral carcinogenesis_Homo sapiens_hsa052031.36062958
25Propanoate metabolism_Homo sapiens_hsa006401.30553895
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29342283
27MicroRNAs in cancer_Homo sapiens_hsa052061.26098306
28Ribosome_Homo sapiens_hsa030101.21253807
29Purine metabolism_Homo sapiens_hsa002301.10923717
30* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10112996
31Epstein-Barr virus infection_Homo sapiens_hsa051691.08555704
32Proteasome_Homo sapiens_hsa030501.04587740
33Alcoholism_Homo sapiens_hsa050341.03367289
34Protein export_Homo sapiens_hsa030601.02631039
35Steroid biosynthesis_Homo sapiens_hsa001001.01735367
36Selenocompound metabolism_Homo sapiens_hsa004501.00016631
37Herpes simplex infection_Homo sapiens_hsa051680.98290189
38TGF-beta signaling pathway_Homo sapiens_hsa043500.97306505
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97190169
40Antigen processing and presentation_Homo sapiens_hsa046120.88967980
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87414187
42HTLV-I infection_Homo sapiens_hsa051660.87332119
43Thyroid cancer_Homo sapiens_hsa052160.81439526
44Hippo signaling pathway_Homo sapiens_hsa043900.79988321
45Vitamin B6 metabolism_Homo sapiens_hsa007500.79744738
46Small cell lung cancer_Homo sapiens_hsa052220.79442867
47Lysine degradation_Homo sapiens_hsa003100.78727588
48Basal cell carcinoma_Homo sapiens_hsa052170.76588584
49Colorectal cancer_Homo sapiens_hsa052100.67559873
50Pyruvate metabolism_Homo sapiens_hsa006200.66695191
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.65628711
52Adherens junction_Homo sapiens_hsa045200.65347630
53Notch signaling pathway_Homo sapiens_hsa043300.61025703
54mTOR signaling pathway_Homo sapiens_hsa041500.60474494
55Biosynthesis of amino acids_Homo sapiens_hsa012300.57245504
56Taste transduction_Homo sapiens_hsa047420.54230067
57Prostate cancer_Homo sapiens_hsa052150.52857002
58Pentose phosphate pathway_Homo sapiens_hsa000300.52316263
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51870218
60Hedgehog signaling pathway_Homo sapiens_hsa043400.51381412
61Fatty acid biosynthesis_Homo sapiens_hsa000610.50047256
62Nicotine addiction_Homo sapiens_hsa050330.48558998
63Pathways in cancer_Homo sapiens_hsa052000.47594482
64Tight junction_Homo sapiens_hsa045300.47245043
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.46497346
66Wnt signaling pathway_Homo sapiens_hsa043100.44881108
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44827005
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44338247
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42659785
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41439595
71Glioma_Homo sapiens_hsa052140.39368752
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.38241554
73FoxO signaling pathway_Homo sapiens_hsa040680.38193403
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37467166
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37295757
76Nitrogen metabolism_Homo sapiens_hsa009100.36967076
77Chronic myeloid leukemia_Homo sapiens_hsa052200.33869230
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33590677
79Butanoate metabolism_Homo sapiens_hsa006500.31268023
80Hepatitis B_Homo sapiens_hsa051610.30894725
81Melanoma_Homo sapiens_hsa052180.29686168
82Endometrial cancer_Homo sapiens_hsa052130.28628753
83Long-term depression_Homo sapiens_hsa047300.28001724
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27570394
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27302453
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.24936743
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.24831122
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24519570
89Influenza A_Homo sapiens_hsa051640.24374392
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24353550
91Apoptosis_Homo sapiens_hsa042100.23857043
92Dorso-ventral axis formation_Homo sapiens_hsa043200.23468265
93Pancreatic cancer_Homo sapiens_hsa052120.22453332
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22075711
95Bladder cancer_Homo sapiens_hsa052190.21395162
96Olfactory transduction_Homo sapiens_hsa047400.21338737
97ErbB signaling pathway_Homo sapiens_hsa040120.21178258
98Non-small cell lung cancer_Homo sapiens_hsa052230.20992230
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20695143
100Fatty acid metabolism_Homo sapiens_hsa012120.20255616
101Inositol phosphate metabolism_Homo sapiens_hsa005620.20127788
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18469839
103Phototransduction_Homo sapiens_hsa047440.17999964
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17891194
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17871793
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17660054
107HIF-1 signaling pathway_Homo sapiens_hsa040660.17167374
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16774587
109Proteoglycans in cancer_Homo sapiens_hsa052050.16305486
110Folate biosynthesis_Homo sapiens_hsa007900.16167024
111Ether lipid metabolism_Homo sapiens_hsa005650.14751245
112Viral myocarditis_Homo sapiens_hsa054160.14493339
113Thyroid hormone synthesis_Homo sapiens_hsa049180.13872750
114Melanogenesis_Homo sapiens_hsa049160.13722394
115Axon guidance_Homo sapiens_hsa043600.13082234
116Renal cell carcinoma_Homo sapiens_hsa052110.12961753
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.11515956
118Circadian rhythm_Homo sapiens_hsa047100.11136639
119Measles_Homo sapiens_hsa051620.11001345
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09737244
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09709821
122Linoleic acid metabolism_Homo sapiens_hsa005910.09600851
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09335255
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07849524
125Legionellosis_Homo sapiens_hsa051340.05477633
126AMPK signaling pathway_Homo sapiens_hsa041520.05171404
127Glucagon signaling pathway_Homo sapiens_hsa049220.04803352
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.04071390
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.03798542
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.02717326
131Glutathione metabolism_Homo sapiens_hsa004800.02686919

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