RILP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.04544385
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.04544385
3L-phenylalanine metabolic process (GO:0006558)5.94408287
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.94408287
5aromatic amino acid family catabolic process (GO:0009074)5.43984810
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.41478768
7kynurenine metabolic process (GO:0070189)5.26200859
8glyoxylate metabolic process (GO:0046487)5.22778024
9lysine metabolic process (GO:0006553)5.16674008
10lysine catabolic process (GO:0006554)5.16674008
11indole-containing compound catabolic process (GO:0042436)4.98168914
12indolalkylamine catabolic process (GO:0046218)4.98168914
13tryptophan catabolic process (GO:0006569)4.98168914
14alpha-linolenic acid metabolic process (GO:0036109)4.83948712
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83066446
16regulation of triglyceride catabolic process (GO:0010896)4.74149057
17bile acid biosynthetic process (GO:0006699)4.69075684
18neutrophil activation involved in immune response (GO:0002283)4.68444896
19tryptophan metabolic process (GO:0006568)4.68340747
20urea cycle (GO:0000050)4.51355714
21urea metabolic process (GO:0019627)4.51355714
22high-density lipoprotein particle remodeling (GO:0034375)4.48326018
232-oxoglutarate metabolic process (GO:0006103)4.47599909
24amino-acid betaine metabolic process (GO:0006577)4.44118295
25negative regulation of fibrinolysis (GO:0051918)4.42422054
26cysteine metabolic process (GO:0006534)4.41060701
27sulfur amino acid catabolic process (GO:0000098)4.37092560
28cellular ketone body metabolic process (GO:0046950)4.36516227
29response to peptidoglycan (GO:0032494)4.32560627
30protein carboxylation (GO:0018214)4.32179362
31peptidyl-glutamic acid carboxylation (GO:0017187)4.32179362
32fatty acid transmembrane transport (GO:1902001)4.30782902
33fatty acid beta-oxidation (GO:0006635)4.29992868
34complement activation, alternative pathway (GO:0006957)4.29505571
35serine family amino acid catabolic process (GO:0009071)4.28195456
36regulation of protein activation cascade (GO:2000257)4.20917538
37regulation of fibrinolysis (GO:0051917)4.17797747
38nitrogen cycle metabolic process (GO:0071941)4.16913748
39acetyl-CoA metabolic process (GO:0006084)4.16640935
40aspartate family amino acid catabolic process (GO:0009068)4.15355418
41carnitine shuttle (GO:0006853)4.11431995
42acylglycerol homeostasis (GO:0055090)4.06448054
43triglyceride homeostasis (GO:0070328)4.06448054
44alpha-amino acid catabolic process (GO:1901606)4.06239205
45negative regulation of interleukin-12 production (GO:0032695)4.05730636
46homocysteine metabolic process (GO:0050667)4.04136954
47regulation of cholesterol esterification (GO:0010872)4.03984649
48fatty acid oxidation (GO:0019395)4.03605889
49short-chain fatty acid metabolic process (GO:0046459)4.03545648
50bile acid metabolic process (GO:0008206)3.99067199
51negative regulation of erythrocyte differentiation (GO:0045647)3.98646718
52plasma lipoprotein particle clearance (GO:0034381)3.98180948
53fatty acid catabolic process (GO:0009062)3.97483667
54aromatic amino acid family metabolic process (GO:0009072)3.96727702
55lipid oxidation (GO:0034440)3.96020309
56regulation of complement activation (GO:0030449)3.94529390
57plasma lipoprotein particle remodeling (GO:0034369)3.90176644
58protein-lipid complex remodeling (GO:0034368)3.90176644
59macromolecular complex remodeling (GO:0034367)3.90176644
60reverse cholesterol transport (GO:0043691)3.90074523
61positive regulation of gamma-delta T cell activation (GO:0046645)3.89175544
62phospholipid efflux (GO:0033700)3.86893814
63dicarboxylic acid biosynthetic process (GO:0043650)3.85677134
64monocarboxylic acid catabolic process (GO:0072329)3.85413612
65ethanol oxidation (GO:0006069)3.85295032
66coenzyme catabolic process (GO:0009109)3.79965565
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.79675127
68carnitine metabolic process (GO:0009437)3.78302828
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.77934350
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.77934350
71modulation by symbiont of host immune response (GO:0052553)3.77934350
72positive regulation by symbiont of host defense response (GO:0052509)3.77934350
73modulation by symbiont of host defense response (GO:0052031)3.77934350
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.77934350
75cellular amino acid catabolic process (GO:0009063)3.77917282
76regulation of sequestering of triglyceride (GO:0010889)3.77577580
77phospholipid homeostasis (GO:0055091)3.77566415
78ketone body metabolic process (GO:1902224)3.76074967
79tyrosine metabolic process (GO:0006570)3.73809540
80cellular response to thyroid hormone stimulus (GO:0097067)3.73663479
81glutamate metabolic process (GO:0006536)3.68453333
82positive regulation of lipid catabolic process (GO:0050996)3.67083433
83negative regulation of cholesterol transport (GO:0032375)3.66923179
84negative regulation of sterol transport (GO:0032372)3.66923179
85macrophage activation involved in immune response (GO:0002281)3.64587816
86organic acid catabolic process (GO:0016054)3.61039065
87carboxylic acid catabolic process (GO:0046395)3.61039065
88immunoglobulin mediated immune response (GO:0016064)3.60878507
89cellular modified amino acid catabolic process (GO:0042219)3.54374301
90negative regulation of cell killing (GO:0031342)3.52734616
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52734616
92valine metabolic process (GO:0006573)3.50279434
93benzene-containing compound metabolic process (GO:0042537)3.48726538
94positive regulation of fatty acid oxidation (GO:0046321)3.48353018
95positive regulation of lipoprotein lipase activity (GO:0051006)3.48100727
96positive regulation of triglyceride lipase activity (GO:0061365)3.48100727
97cellular glucuronidation (GO:0052695)3.46941942
98cholesterol efflux (GO:0033344)3.43350662
99indolalkylamine metabolic process (GO:0006586)3.43224094
100negative regulation of fatty acid biosynthetic process (GO:0045717)3.39301279
101glycine metabolic process (GO:0006544)3.39271953
102regulation of fatty acid oxidation (GO:0046320)3.39046669
103lipopolysaccharide-mediated signaling pathway (GO:0031663)3.38569219
104branched-chain amino acid catabolic process (GO:0009083)3.38208893
105drug catabolic process (GO:0042737)3.36191244
106regulation of cholesterol homeostasis (GO:2000188)3.36014300
107negative regulation of lipase activity (GO:0060192)3.35521167
108bile acid and bile salt transport (GO:0015721)3.35231324
109arginine metabolic process (GO:0006525)3.35223033
110detection of other organism (GO:0098543)3.35215923
111plasma lipoprotein particle assembly (GO:0034377)3.34474124
112cholesterol homeostasis (GO:0042632)3.33129360
113cellular biogenic amine catabolic process (GO:0042402)3.32691875
114amine catabolic process (GO:0009310)3.32691875
115tricarboxylic acid cycle (GO:0006099)3.32689334
116sterol homeostasis (GO:0055092)3.27855048
117serine family amino acid metabolic process (GO:0009069)3.25794753
118carnitine transmembrane transport (GO:1902603)3.25020340
119regulation of mast cell degranulation (GO:0043304)3.23169747
120detection of bacterium (GO:0016045)3.22170557
121germinal center formation (GO:0002467)3.16072001
122glycosphingolipid catabolic process (GO:0046479)3.13292201
123granulocyte activation (GO:0036230)3.07974336
124oxygen transport (GO:0015671)3.01449280
125response to thyroid hormone (GO:0097066)3.00443681
126antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99464517
127antigen processing and presentation of endogenous antigen (GO:0019883)2.98270879
128positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97696615
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93241465
130detection of external biotic stimulus (GO:0098581)2.92188143
131NIK/NF-kappaB signaling (GO:0038061)2.88314237
132negative regulation of cytokine production involved in immune response (GO:0002719)2.87259316
133low-density lipoprotein particle clearance (GO:0034383)2.86874318
134regulation of mast cell activation involved in immune response (GO:0033006)2.86222478
135regulation of interferon-beta biosynthetic process (GO:0045357)2.84207720
136neutrophil activation (GO:0042119)2.82571751
137detection of molecule of bacterial origin (GO:0032490)2.82459219
138glycolipid catabolic process (GO:0019377)2.80902849
139defense response to protozoan (GO:0042832)2.80255683
140response to protozoan (GO:0001562)2.79970276
141type I interferon signaling pathway (GO:0060337)2.76938627
142cellular response to type I interferon (GO:0071357)2.76938627
143regulation of necroptotic process (GO:0060544)2.76502786
144regulation of gamma-delta T cell activation (GO:0046643)2.76399515
145myeloid dendritic cell differentiation (GO:0043011)2.75398294
146regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75198353
147regulation of leukocyte degranulation (GO:0043300)2.74792758
148T-helper 1 type immune response (GO:0042088)2.74567468
149regulation of necrotic cell death (GO:0010939)2.73709370
150response to type I interferon (GO:0034340)2.72726582
151protoporphyrinogen IX metabolic process (GO:0046501)2.70706522
152negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68611353
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.68238578
154interferon-gamma-mediated signaling pathway (GO:0060333)2.66765883
155oligosaccharide catabolic process (GO:0009313)2.66605030
156positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.65958925
157regulation of cholesterol storage (GO:0010885)2.65408523
158myeloid cell activation involved in immune response (GO:0002275)2.63220888
159amino sugar catabolic process (GO:0046348)2.60567254
160creatine metabolic process (GO:0006600)2.60476267
161negative regulation of myeloid cell apoptotic process (GO:0033033)2.60080321
162sarcoplasmic reticulum calcium ion transport (GO:0070296)2.59545964
163macrophage activation (GO:0042116)2.58765378
164B cell mediated immunity (GO:0019724)2.58234373
165response to host immune response (GO:0052572)2.57743837
166response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57743837
167NADH metabolic process (GO:0006734)2.56168311
168gas transport (GO:0015669)2.55459882
169response to muramyl dipeptide (GO:0032495)2.55020822
170hemoglobin metabolic process (GO:0020027)2.53883902
171myeloid dendritic cell activation (GO:0001773)2.51952963
172regulation of dendritic cell antigen processing and presentation (GO:0002604)2.51341641
173regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.51232556
174regulation of interferon-alpha production (GO:0032647)2.48675443
175modulation by symbiont of host cellular process (GO:0044068)2.48415297
176detection of biotic stimulus (GO:0009595)2.48028663
177positive regulation of antigen processing and presentation (GO:0002579)2.48019586
178regulation of membrane protein ectodomain proteolysis (GO:0051043)2.47140077
179positive regulation of B cell differentiation (GO:0045579)2.46747644
180regulation of superoxide anion generation (GO:0032928)2.46247810
181negative regulation of nitric oxide biosynthetic process (GO:0045019)2.45358724
182positive regulation of cellular amide metabolic process (GO:0034250)2.44651974
183positive regulation of chemokine biosynthetic process (GO:0045080)2.44501707
184ceramide catabolic process (GO:0046514)2.43713268
185positive regulation of mast cell activation (GO:0033005)2.40908331
186regulation of T-helper 2 cell differentiation (GO:0045628)2.40554447
187negative regulation of necroptotic process (GO:0060546)2.40146194
188respiratory burst (GO:0045730)2.39809798
189barbed-end actin filament capping (GO:0051016)2.39692815
190cellular extravasation (GO:0045123)2.39551286
191regulation of antigen processing and presentation (GO:0002577)2.38995343
192adenosine receptor signaling pathway (GO:0001973)2.38630088
193positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.36985845
194regulation of mast cell activation (GO:0033003)2.36568209
195positive regulation of cholesterol efflux (GO:0010875)2.36180946
196regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.35767577
197positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.35402640
198dendritic cell differentiation (GO:0097028)2.34936422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.10568937
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.63287755
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.26494921
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.64552144
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.12514571
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.72467470
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.86458913
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.79312551
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.19899313
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.84721579
11VDR_21846776_ChIP-Seq_THP-1_Human2.78950595
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.69416989
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60339196
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50784272
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41156456
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28653575
17SCL_19346495_ChIP-Seq_HPC-7_Human2.25762133
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.24112477
19VDR_24763502_ChIP-Seq_THP-1_Human2.23644903
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15036411
21CLOCK_20551151_ChIP-Seq_293T_Human2.07277903
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1361591
23SPI1_23127762_ChIP-Seq_K562_Human1.98815908
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.98281857
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96876130
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.92026718
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91741795
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90412402
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86097815
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.84377176
31* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81134112
32* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78987777
33MAF_26560356_Chip-Seq_TH1_Human1.78397220
34TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.78061321
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76946906
36MYC_22102868_ChIP-Seq_BL_Human1.75384135
37TCF7_22412390_ChIP-Seq_EML_Mouse1.73674057
38SPI1_23547873_ChIP-Seq_NB4_Human1.72219194
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70804822
40ZNF263_19887448_ChIP-Seq_K562_Human1.70342000
41* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70113862
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65868755
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65301304
44KDM2B_26808549_Chip-Seq_DND41_Human1.65188053
45* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61797649
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60315508
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60272556
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.57937226
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57813204
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.52975115
51UTX_26944678_Chip-Seq_JUKART_Human1.52633152
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51087901
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.48519917
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44631633
55MAF_26560356_Chip-Seq_TH2_Human1.44063804
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.42812167
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.42812167
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41330200
59NCOR1_26117541_ChIP-Seq_K562_Human1.40590224
60GATA1_22025678_ChIP-Seq_K562_Human1.40417511
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39670056
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39468283
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39413613
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37123665
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34779426
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32310193
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31821591
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.31819455
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29794837
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28388836
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.26893687
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26139468
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22905096
74HNF4A_19822575_ChIP-Seq_HepG2_Human1.22818462
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.20891003
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20739339
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20551368
78* P68_20966046_ChIP-Seq_HELA_Human1.19905678
79* SA1_27219007_Chip-Seq_ERYTHROID_Human1.19197063
80* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18699976
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16025892
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15969108
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15189354
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.12706587
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11919239
86MYB_26560356_Chip-Seq_TH2_Human1.09516430
87VDR_24787735_ChIP-Seq_THP-1_Human1.08061540
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07824974
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07343228
90HTT_18923047_ChIP-ChIP_STHdh_Human1.05316161
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03941150
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03785572
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.02907995
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02220177
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01894256
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01756186
97RUNX_20019798_ChIP-Seq_JUKART_Human1.01424693
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00054120
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.99408256
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99328879
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99097655
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98562336
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95307341
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91781203
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91331282
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91056235
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91034967
108LXR_22292898_ChIP-Seq_THP-1_Human0.90710268
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90681175
110RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89310297
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87820865
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87732261
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86318187
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83633017
115GATA4_25053715_ChIP-Seq_YYC3_Human0.82206276
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82164563
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80922485
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.79436056
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79333281
120IRF8_22096565_ChIP-ChIP_GC-B_Human0.75728079
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74712280
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74712280
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73946457
124EGR1_19032775_ChIP-ChIP_M12_Human0.73572757
125GATA1_19941826_ChIP-Seq_K562_Human0.72651648
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72456198
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71004602
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70635422
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.70516025
130* RACK7_27058665_Chip-Seq_MCF-7_Human0.69370118
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.69123232
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.68267549
133* GATA2_19941826_ChIP-Seq_K562_Human0.67372950
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67129071
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65608223
136CEBPB_22108803_ChIP-Seq_LS180_Human0.64142678
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63887534
138RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63221836
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.59104947
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.59091416
141BCOR_27268052_Chip-Seq_Bcells_Human0.57824678
142NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.57083931
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.57042255
144* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56883988
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56783493
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.56640232
147* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.56503425
148PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.56406529
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.56248584
150CDX2_20551321_ChIP-Seq_CACO-2_Human0.54968699
151ESR1_15608294_ChIP-ChIP_MCF-7_Human0.54862319
152BCL6_27268052_Chip-Seq_Bcells_Human0.54266275
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54211756
154OCT4_20526341_ChIP-Seq_ESCs_Human0.52767407
155CTCF_27219007_Chip-Seq_Bcells_Human0.52365726
156* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52038216
157KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.51388419
158CBP_21632823_ChIP-Seq_H3396_Human0.51360028
159TAF2_19829295_ChIP-Seq_ESCs_Human0.51310312
160* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.51189169
161GATA6_25053715_ChIP-Seq_YYC3_Human0.51022729
162MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.50705973
163SPI1_20517297_ChIP-Seq_HL60_Human0.50030511
164GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.49541097
165CSB_26484114_Chip-Seq_FIBROBLAST_Human0.49339130
166FOXA1_25552417_ChIP-Seq_VCAP_Human0.48500827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.45105954
2MP0005360_urolithiasis6.06211296
3MP0005085_abnormal_gallbladder_physiolo5.12629713
4MP0005365_abnormal_bile_salt4.83134846
5MP0003303_peritoneal_inflammation4.00113027
6MP0008875_abnormal_xenobiotic_pharmacok3.93883156
7MP0003806_abnormal_nucleotide_metabolis3.53105580
8MP0002837_dystrophic_cardiac_calcinosis3.42003442
9MP0009840_abnormal_foam_cell3.19818468
10MP0003724_increased_susceptibility_to3.16992559
11MP0003436_decreased_susceptibility_to3.14078300
12MP0003252_abnormal_bile_duct3.11523768
13MP0010329_abnormal_lipoprotein_level3.00236673
14MP0003646_muscle_fatigue2.98093147
15MP0005083_abnormal_biliary_tract2.63477495
16MP0009785_altered_susceptibility_to2.55105300
17MP0002148_abnormal_hypersensitivity_rea2.52300562
18MP0003195_calcinosis2.52290522
19MP0005332_abnormal_amino_acid2.47992879
20MP0006082_CNS_inflammation2.39160355
21MP0003191_abnormal_cellular_cholesterol2.34950097
22MP0002419_abnormal_innate_immunity2.33854357
23MP0001835_abnormal_antigen_presentation2.31467840
24MP0005025_abnormal_response_to2.24392474
25MP0005397_hematopoietic_system_phenotyp2.20376210
26MP0001545_abnormal_hematopoietic_system2.20376210
27MP0005464_abnormal_platelet_physiology2.18990987
28MP0004130_abnormal_muscle_cell2.15618149
29MP0000751_myopathy2.11595985
30MP0005000_abnormal_immune_tolerance2.08069844
31MP0009278_abnormal_bone_marrow2.08018120
32MP0001666_abnormal_nutrient_absorption2.06421130
33MP0004084_abnormal_cardiac_muscle2.06343481
34MP0005387_immune_system_phenotype2.05777887
35MP0001790_abnormal_immune_system2.05777887
36MP0002118_abnormal_lipid_homeostasis1.98391661
37MP0004036_abnormal_muscle_relaxation1.93513879
38MP0003300_gastrointestinal_ulcer1.93360165
39MP0000609_abnormal_liver_physiology1.86105829
40MP0003075_altered_response_to1.85888259
41MP0005330_cardiomyopathy1.83617274
42MP0005319_abnormal_enzyme/_coenzyme1.79352712
43MP0000749_muscle_degeneration1.76836506
44MP0003172_abnormal_lysosome_physiology1.74839663
45MP0005670_abnormal_white_adipose1.72632238
46MP0001533_abnormal_skeleton_physiology1.72236466
47MP0000685_abnormal_immune_system1.71563952
48MP0005671_abnormal_response_to1.69878292
49MP0002723_abnormal_immune_serum1.68586181
50MP0002452_abnormal_antigen_presenting1.66622998
51MP0004215_abnormal_myocardial_fiber1.65406982
52MP0002138_abnormal_hepatobiliary_system1.62443851
53MP0006036_abnormal_mitochondrial_physio1.62375997
54MP0001800_abnormal_humoral_immune1.58326910
55MP0005451_abnormal_body_composition1.58077275
56MP0004019_abnormal_vitamin_homeostasis1.56919600
57MP0008260_abnormal_autophagy1.55849648
58MP0004947_skin_inflammation1.53658236
59MP0010155_abnormal_intestine_physiology1.53056714
60MP0002420_abnormal_adaptive_immunity1.52748382
61MP0001819_abnormal_immune_cell1.52411645
62MP0003705_abnormal_hypodermis_morpholog1.49912305
63MP0005584_abnormal_enzyme/coenzyme_acti1.48797493
64MP0001845_abnormal_inflammatory_respons1.45138025
65MP0008004_abnormal_stomach_pH1.44316604
66MP0004087_abnormal_muscle_fiber1.42041682
67MP0002405_respiratory_system_inflammati1.38071261
68MP0005666_abnormal_adipose_tissue1.36775234
69MP0002269_muscular_atrophy1.35352612
70MP0009333_abnormal_splenocyte_physiolog1.33178387
71MP0005166_decreased_susceptibility_to1.31542493
72MP0002998_abnormal_bone_remodeling1.27601330
73MP0008775_abnormal_heart_ventricle1.26969787
74MP0010368_abnormal_lymphatic_system1.25399127
75MP0002132_abnormal_respiratory_system1.25236199
76MP0002972_abnormal_cardiac_muscle1.23712679
77MP0000858_altered_metastatic_potential1.23476107
78MP0009643_abnormal_urine_homeostasis1.22608697
79MP0005620_abnormal_muscle_contractility1.20827201
80MP0002971_abnormal_brown_adipose1.20398091
81MP0005385_cardiovascular_system_phenoty1.19340493
82MP0001544_abnormal_cardiovascular_syste1.19340493
83MP0003656_abnormal_erythrocyte_physiolo1.17854518
84MP0003453_abnormal_keratinocyte_physiol1.17660468
85MP0001764_abnormal_homeostasis1.16628772
86MP0003868_abnormal_feces_composition1.12983462
87MP0002398_abnormal_bone_marrow1.11239424
88MP0010630_abnormal_cardiac_muscle1.11066672
89MP0000716_abnormal_immune_system1.10389975
90MP0000747_muscle_weakness1.09968778
91MP0003186_abnormal_redox_activity1.07487603
92MP0000465_gastrointestinal_hemorrhage1.06007765
93MP0006138_congestive_heart_failure1.05930930
94MP0002106_abnormal_muscle_physiology1.01088348
95MP0000750_abnormal_muscle_regeneration1.00919001
96MP0009697_abnormal_copulation1.00499751
97MP0006035_abnormal_mitochondrial_morpho0.99025995
98MP0000689_abnormal_spleen_morphology0.98149413
99MP0002429_abnormal_blood_cell0.98124900
100MP0003221_abnormal_cardiomyocyte_apopto0.98054256
101MP0005310_abnormal_salivary_gland0.97187846
102MP0000598_abnormal_liver_morphology0.95000249
103MP0002078_abnormal_glucose_homeostasis0.94600405
104MP0002332_abnormal_exercise_endurance0.93885801
105MP0003448_altered_tumor_morphology0.93692022
106MP0003137_abnormal_impulse_conducting0.93612598
107MP0005266_abnormal_metabolism0.93480361
108MP0002722_abnormal_immune_system0.93428935
109MP0003011_delayed_dark_adaptation0.89740471
110MP0009763_increased_sensitivity_to0.87505648
111MP0009764_decreased_sensitivity_to0.87260496
112MP0005535_abnormal_body_temperature0.86341757
113MP0004185_abnormal_adipocyte_glucose0.85835015
114MP0005334_abnormal_fat_pad0.84568699
115MP0008874_decreased_physiological_sensi0.83500122
116MP0000759_abnormal_skeletal_muscle0.83487748
117MP0000604_amyloidosis0.82548345
118MP0001663_abnormal_digestive_system0.82081799
119MP0005164_abnormal_response_to0.79379379
120MP0009642_abnormal_blood_homeostasis0.78869325
121MP0005369_muscle_phenotype0.78559130
122MP0001851_eye_inflammation0.78401304
123MP0004484_altered_response_of0.77966032
124MP0008469_abnormal_protein_level0.77405343
125MP0004145_abnormal_muscle_electrophysio0.76615319
126MP0005375_adipose_tissue_phenotype0.74819928
127MP0005636_abnormal_mineral_homeostasis0.74765401
128MP0005376_homeostasis/metabolism_phenot0.73603742
129MP0003879_abnormal_hair_cell0.73333767
130MP0005647_abnormal_sex_gland0.72200234
131MP0000230_abnormal_systemic_arterial0.70003415
132MP0004085_abnormal_heartbeat0.67944802
133MP0000343_altered_response_to0.66051423
134MP0004510_myositis0.62902432
135MP0004043_abnormal_pH_regulation0.59936041
136MP0005165_increased_susceptibility_to0.59292885
137MP0001756_abnormal_urination0.57470960
138MP0005448_abnormal_energy_balance0.57423628
139MP0005167_abnormal_blood-brain_barrier0.56711075
140MP0009115_abnormal_fat_cell0.55310450
141MP0003828_pulmonary_edema0.54190508
142MP0005084_abnormal_gallbladder_morpholo0.52510148
143MP0003690_abnormal_glial_cell0.51303413
144MP0002127_abnormal_cardiovascular_syste0.51041728
145MP0003329_amyloid_beta_deposits0.50220021
146MP0002254_reproductive_system_inflammat0.49358678
147MP0000249_abnormal_blood_vessel0.47327273
148MP0004147_increased_porphyrin_level0.46858391
149MP0001853_heart_inflammation0.45863606
150MP0001661_extended_life_span0.45762124
151MP0005058_abnormal_lysosome_morphology0.45223416
152MP0002128_abnormal_blood_circulation0.45100480

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.40889875
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.25456816
3Intrahepatic cholestasis (HP:0001406)5.13679532
4Xanthomatosis (HP:0000991)4.98635483
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.69400061
6Abnormality of glycolipid metabolism (HP:0010969)4.60180913
7Abnormality of liposaccharide metabolism (HP:0010968)4.60180913
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.60180913
9Hypobetalipoproteinemia (HP:0003563)4.42258386
10Hyperlipoproteinemia (HP:0010980)4.39927545
11Hyperammonemia (HP:0001987)4.35864538
12Ketosis (HP:0001946)4.33369963
13Hypoglycemic coma (HP:0001325)4.33161755
14Prolonged partial thromboplastin time (HP:0003645)4.32833539
15Eczematoid dermatitis (HP:0000976)4.10580984
16Abnormality of macrophages (HP:0004311)4.09632193
17Hyperglycinuria (HP:0003108)4.01901206
18Abnormality of fatty-acid metabolism (HP:0004359)3.96117600
19Hypoalphalipoproteinemia (HP:0003233)3.89936005
20Hypolipoproteinemia (HP:0010981)3.87639672
21Abnormality of the heme biosynthetic pathway (HP:0010472)3.86389171
22Complement deficiency (HP:0004431)3.83499830
23Ketoacidosis (HP:0001993)3.78980067
24Myoglobinuria (HP:0002913)3.78127647
25Recurrent abscess formation (HP:0002722)3.76181777
26Abnormality of serine family amino acid metabolism (HP:0010894)3.75276806
27Abnormality of glycine metabolism (HP:0010895)3.75276806
28Hyperglycinemia (HP:0002154)3.66732001
29Recurrent bacterial skin infections (HP:0005406)3.63726741
30Exercise-induced myalgia (HP:0003738)3.59626035
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.55584406
32Sudden death (HP:0001699)3.46158303
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45703845
34Petechiae (HP:0000967)3.45599365
35Epidermoid cyst (HP:0200040)3.42975360
36Myositis (HP:0100614)3.42318398
37Abnormality of glutamine family amino acid metabolism (HP:0010902)3.38730009
38Joint hemorrhage (HP:0005261)3.36198244
39Exercise-induced muscle cramps (HP:0003710)3.35931021
40Orchitis (HP:0100796)3.34026062
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.30851481
42Dicarboxylic aciduria (HP:0003215)3.30851481
43Increased serum ferritin (HP:0003281)3.26493700
44Abnormality of aspartate family amino acid metabolism (HP:0010899)3.21555642
45Recurrent gram-negative bacterial infections (HP:0005420)3.20487654
46Polycythemia (HP:0001901)3.17343683
47Rhabdomyolysis (HP:0003201)3.09910232
48Abnormality of sulfur amino acid metabolism (HP:0004339)3.08997153
49Increased cerebral lipofuscin (HP:0011813)3.07574649
50Muscle fiber inclusion bodies (HP:0100299)3.07231548
51Abnormality of the common coagulation pathway (HP:0010990)3.04607218
52Abnormality of methionine metabolism (HP:0010901)3.02691243
53Stomatitis (HP:0010280)3.02581837
54Prolonged bleeding time (HP:0003010)2.99909612
55Purpura (HP:0000979)2.99348782
56Nemaline bodies (HP:0003798)2.97413644
57Ventricular tachycardia (HP:0004756)2.95879134
58Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.95712202
59Calf muscle hypertrophy (HP:0008981)2.94772332
60Optic neuritis (HP:0100653)2.91963533
61Retrobulbar optic neuritis (HP:0100654)2.91963533
62Metabolic acidosis (HP:0001942)2.91616678
63Abnormality of iron homeostasis (HP:0011031)2.90645063
64Cerebral edema (HP:0002181)2.90198561
65Obstructive lung disease (HP:0006536)2.88668258
66Chronic obstructive pulmonary disease (HP:0006510)2.88668258
67Dysostosis multiplex (HP:0000943)2.86382375
68Loss of speech (HP:0002371)2.86059360
69Hypercholesterolemia (HP:0003124)2.84198600
70Right ventricular cardiomyopathy (HP:0011663)2.82634577
71Vacuolated lymphocytes (HP:0001922)2.82094227
72Muscle hypertrophy of the lower extremities (HP:0008968)2.79077309
73Hypochromic microcytic anemia (HP:0004840)2.78834376
74Fat malabsorption (HP:0002630)2.78253744
75Abnormality of complement system (HP:0005339)2.76947729
76Abnormality of serum amino acid levels (HP:0003112)2.72343990
77Gout (HP:0001997)2.72236390
78Muscle fiber splitting (HP:0003555)2.71741071
79Hyporeflexia of lower limbs (HP:0002600)2.69263492
80Skin nodule (HP:0200036)2.68369505
81Abnormality of the intrinsic pathway (HP:0010989)2.65699294
82Lethargy (HP:0001254)2.64606849
83Centrally nucleated skeletal muscle fibers (HP:0003687)2.63324789
84Disinhibition (HP:0000734)2.62691832
85Myopathic facies (HP:0002058)2.62098400
86Cholelithiasis (HP:0001081)2.61546550
87Abnormality of purine metabolism (HP:0004352)2.61381451
88Mediastinal lymphadenopathy (HP:0100721)2.57730398
89Generalized aminoaciduria (HP:0002909)2.57689261
90Hyperbilirubinemia (HP:0002904)2.56646861
91Distal lower limb muscle weakness (HP:0009053)2.53487056
92Axonal loss (HP:0003447)2.53333295
93Abnormality of nucleobase metabolism (HP:0010932)2.53175276
94Abnormal gallbladder morphology (HP:0012437)2.52387659
95Elevated erythrocyte sedimentation rate (HP:0003565)2.51363985
96Epistaxis (HP:0000421)2.50541276
97Palpitations (HP:0001962)2.50495358
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.48764787
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48702116
100Amyloidosis (HP:0011034)2.45908939
101Hepatosplenomegaly (HP:0001433)2.45673470
102Asymmetric septal hypertrophy (HP:0001670)2.45330161
103Spontaneous hematomas (HP:0007420)2.44152817
104Myocardial infarction (HP:0001658)2.41994623
105Lipoatrophy (HP:0100578)2.38034128
106Abnormality of pyrimidine metabolism (HP:0004353)2.36762925
107Delayed CNS myelination (HP:0002188)2.36119870
108Abnormality of transition element cation homeostasis (HP:0011030)2.35060817
109Paralysis (HP:0003470)2.34109460
110Hepatic necrosis (HP:0002605)2.33825890
111Microcytic anemia (HP:0001935)2.33533641
112Atrioventricular block (HP:0001678)2.33211645
113Gastrointestinal infarctions (HP:0005244)2.33113777
114Hyperinsulinemic hypoglycemia (HP:0000825)2.32607181
115Increased connective tissue (HP:0009025)2.32427974
116Conjugated hyperbilirubinemia (HP:0002908)2.31019206
117Type 1 muscle fiber predominance (HP:0003803)2.28211020
118Vomiting (HP:0002013)2.25785763
119Reticulocytosis (HP:0001923)2.25186132
120Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24009376
121Abnormality of polysaccharide metabolism (HP:0011012)2.24009376
122Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24009376
123Poikilocytosis (HP:0004447)2.22629392
124Hypochromic anemia (HP:0001931)2.20129464
125Late onset (HP:0003584)2.19614886
126Glomerulonephritis (HP:0000099)2.19310510
127Keratoconjunctivitis sicca (HP:0001097)2.19084082
128Urticaria (HP:0001025)2.18193165
129Dilated cardiomyopathy (HP:0001644)2.18045026
130Hepatocellular carcinoma (HP:0001402)2.17417852
131Nausea (HP:0002018)2.17291187
132Abnormality of the calf musculature (HP:0001430)2.17108407
133Systemic lupus erythematosus (HP:0002725)2.16579850
134Hypoglycemic seizures (HP:0002173)2.16293106
135Atrial fibrillation (HP:0005110)2.14663874
136Gingivitis (HP:0000230)2.14650945
137Syncope (HP:0001279)2.13802725
138Hypertensive crisis (HP:0100735)2.13607672
139Autoimmune thrombocytopenia (HP:0001973)2.10564808
140Mutism (HP:0002300)2.10045187
141Increased muscle lipid content (HP:0009058)2.09742440
142Cellulitis (HP:0100658)2.09608817
143Recurrent skin infections (HP:0001581)2.09192925
144Hypertriglyceridemia (HP:0002155)2.08722527
145Hyperglycemia (HP:0003074)2.08518556
146EMG: myopathic abnormalities (HP:0003458)2.08211990
147Proximal tubulopathy (HP:0000114)2.07934845
148Gingival bleeding (HP:0000225)2.06979127
149Heart block (HP:0012722)2.06350224
150Vascular calcification (HP:0004934)2.05827214
151Hyperuricemia (HP:0002149)2.03716022
152Increased purine levels (HP:0004368)2.03716022
153Spontaneous abortion (HP:0005268)2.02676351
154Abnormality of skeletal muscle fiber size (HP:0012084)2.02040148
155Arterial thrombosis (HP:0004420)2.01754595
156Recurrent fungal infections (HP:0002841)2.01349832
157Impaired platelet aggregation (HP:0003540)2.01293416
158Abnormal platelet function (HP:0011869)2.01293416
159Muscle stiffness (HP:0003552)2.00155127
160Steatorrhea (HP:0002570)1.99835575
161Neonatal onset (HP:0003623)1.99378206
162Chest pain (HP:0100749)1.98419051
163Esophageal varix (HP:0002040)1.98351386
164Meningitis (HP:0001287)1.98166800
165Abnormal gallbladder physiology (HP:0012438)1.96877376
166Cholecystitis (HP:0001082)1.96877376
167Ragged-red muscle fibers (HP:0003200)1.96212202
168Bulbar palsy (HP:0001283)1.95975679
169Episodic fever (HP:0001954)1.95904287
170Urinary glycosaminoglycan excretion (HP:0003541)1.95680588
171Mucopolysacchariduria (HP:0008155)1.95680588
172Difficulty running (HP:0009046)1.94887662
173Primary atrial arrhythmia (HP:0001692)1.94870876
174Vasculitis (HP:0002633)1.94151078
175Acute encephalopathy (HP:0006846)1.93020999
176Abnormal atrioventricular conduction (HP:0005150)1.92952827
177Hydroxyprolinuria (HP:0003080)1.91760387
178Abnormality of proline metabolism (HP:0010907)1.91760387
179Encephalitis (HP:0002383)1.91666936
180Keratoconjunctivitis (HP:0001096)1.91293319
181Increased IgE level (HP:0003212)1.91169341
182Nuclear cataract (HP:0100018)1.90951739
183Neurofibrillary tangles (HP:0002185)1.86698284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.51057559
2TTN4.05034389
3TRIB33.35944559
4RIPK43.34901446
5PKN23.21049650
6OBSCN3.17798715
7SIK12.80522497
8ERN12.61568231
9PRPF4B2.59094986
10PHKG12.58875338
11PHKG22.58875338
12FGFR42.56033998
13PDK32.44988206
14PDK42.44988206
15NME22.42913945
16BLK2.26894212
17TAOK12.24384538
18PINK12.18042558
19MAP4K12.13315613
20INSRR2.10242888
21MYLK1.91273355
22LMTK21.89160371
23TIE11.86854040
24IRAK41.81131612
25MAP2K31.75968301
26MAP3K11.75700634
27ZAP701.63337231
28PDK21.52820411
29MAP3K71.49879358
30FLT31.48333361
31PIK3CA1.48123499
32PIK3CG1.43207067
33FGR1.36976221
34MATK1.36895552
35NEK11.36075029
36MAP2K41.36061599
37IKBKE1.33536239
38NEK91.32332556
39IKBKB1.32268165
40JAK31.31996228
41PRKAA21.30357470
42FES1.27382057
43PTK61.26674320
44MST1R1.25864386
45TNK21.24082698
46RIPK11.21023935
47TESK21.19352981
48PIM21.17543401
49GRK61.17540091
50TAOK31.16852880
51SYK1.16798137
52MAPK121.15702445
53DMPK1.14904683
54MAP3K131.13943215
55KDR1.12291697
56MAPK111.11700304
57EPHB11.07420360
58ERBB41.07226126
59TGFBR21.06475736
60TYK21.06393481
61TBK11.06047109
62MAP3K31.03172908
63LATS11.01397248
64BTK1.00998382
65MOS0.99190289
66PRKAA10.98635844
67BMX0.95807509
68MUSK0.94806330
69HCK0.91895720
70CDC42BPA0.91627348
71LYN0.88010874
72STK38L0.87448016
73PAK30.85363462
74DDR20.85234311
75STK240.84832636
76ABL20.84185718
77MARK30.83693000
78MAP3K50.82980574
79CAMK1D0.82020975
80JAK20.80656442
81MAP2K60.79803444
82KSR20.78772181
83PRKD10.78346952
84TXK0.75285364
85CSF1R0.73992131
86JAK10.73773481
87PDPK10.66909516
88PRKACG0.65506397
89MAP3K80.65055309
90DAPK20.64854900
91MAP3K110.63234423
92TESK10.61203498
93SIK30.60170140
94SCYL20.60041712
95LCK0.58901327
96MARK20.58459407
97CAMK2G0.58181001
98RPS6KC10.57686818
99RPS6KL10.57686818
100IRAK30.57608056
101GRK70.56985325
102BMPR20.56955295
103IRAK20.56263659
104TAOK20.56245674
105PIM10.55484255
106CAMK40.54885098
107WNK40.54301828
108MAPKAPK30.54218622
109PRKG20.53533531
110MAPK40.53436722
111PKN10.53107887
112SGK30.52503477
113PDGFRA0.51538978
114CAMK2D0.50470304
115KIT0.47664039
116EPHA30.47408766
117SMG10.43982175
118PDK10.43497282
119MAP3K100.43214756
120RPS6KA60.43022718
121ROCK10.42066548
122HIPK20.41754994
123STK100.41511627
124TRPM70.41305119
125ARAF0.41253013
126MET0.40801441
127EIF2AK10.40598589
128PRKD20.39897985
129CAMK1G0.39058852
130MAP2K10.39025043
131STK40.38961797
132ACVR1B0.38881515
133FGFR30.37871139
134CLK10.37262160
135MAP3K140.36977598
136RET0.36321888
137DAPK30.36149857
138ICK0.35914072
139DYRK1B0.35555502
140GSK3A0.35322046
141FRK0.33846910
142CSK0.33730899
143ILK0.33229302
144STK380.33088215
145PRKACB0.32083329
146PRKCZ0.31910798
147MAP3K60.31563354
148MTOR0.31121608
149MAPK70.30192310
150LRRK20.29161970
151PRKACA0.28724111
152FGFR20.28368904
153PRKCQ0.26256731
154ERBB20.26150554
155AKT20.24193514

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.84788479
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.67790970
3Other glycan degradation_Homo sapiens_hsa005113.19417027
4Fatty acid degradation_Homo sapiens_hsa000713.11043960
5Arginine biosynthesis_Homo sapiens_hsa002202.88708028
6Nitrogen metabolism_Homo sapiens_hsa009102.85725161
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82513416
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74898326
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74489590
10Propanoate metabolism_Homo sapiens_hsa006402.72767392
11Osteoclast differentiation_Homo sapiens_hsa043802.71976799
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.68305554
13Tryptophan metabolism_Homo sapiens_hsa003802.57889786
14Leishmaniasis_Homo sapiens_hsa051402.57395383
15Malaria_Homo sapiens_hsa051442.44510866
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37432250
17Fatty acid metabolism_Homo sapiens_hsa012122.29169347
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28838507
19Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28444675
20Butanoate metabolism_Homo sapiens_hsa006502.26288549
21Complement and coagulation cascades_Homo sapiens_hsa046102.21632733
22Lysosome_Homo sapiens_hsa041422.14390226
23PPAR signaling pathway_Homo sapiens_hsa033202.14139647
24Peroxisome_Homo sapiens_hsa041462.04697382
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03426168
26Allograft rejection_Homo sapiens_hsa053302.00906107
27Tuberculosis_Homo sapiens_hsa051521.92721394
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92001615
29Rheumatoid arthritis_Homo sapiens_hsa053231.77794026
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.76568672
31Pyruvate metabolism_Homo sapiens_hsa006201.76543768
32Carbon metabolism_Homo sapiens_hsa012001.75316689
33Asthma_Homo sapiens_hsa053101.72301680
34beta-Alanine metabolism_Homo sapiens_hsa004101.71842349
35Pertussis_Homo sapiens_hsa051331.71758511
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.69903342
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69452101
38Graft-versus-host disease_Homo sapiens_hsa053321.62235674
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61496239
40Autoimmune thyroid disease_Homo sapiens_hsa053201.57631477
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56439691
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55730751
43African trypanosomiasis_Homo sapiens_hsa051431.55207663
44Caffeine metabolism_Homo sapiens_hsa002321.55088091
45Starch and sucrose metabolism_Homo sapiens_hsa005001.54683090
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54444399
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52624544
48TNF signaling pathway_Homo sapiens_hsa046681.52161523
49Chemical carcinogenesis_Homo sapiens_hsa052041.51690873
50Fatty acid elongation_Homo sapiens_hsa000621.51567745
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47779539
52Histidine metabolism_Homo sapiens_hsa003401.46024950
53Phenylalanine metabolism_Homo sapiens_hsa003601.45599387
54Staphylococcus aureus infection_Homo sapiens_hsa051501.43472141
55Hematopoietic cell lineage_Homo sapiens_hsa046401.42730411
56Legionellosis_Homo sapiens_hsa051341.42546859
57Acute myeloid leukemia_Homo sapiens_hsa052211.41485644
58Toxoplasmosis_Homo sapiens_hsa051451.39256035
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38524594
60B cell receptor signaling pathway_Homo sapiens_hsa046621.37799175
61Bile secretion_Homo sapiens_hsa049761.37596476
62Biosynthesis of amino acids_Homo sapiens_hsa012301.34775597
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.29814424
64Intestinal immune network for IgA production_Homo sapiens_hsa046721.28844769
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28615946
66Influenza A_Homo sapiens_hsa051641.28273379
67Drug metabolism - other enzymes_Homo sapiens_hsa009831.28027805
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27556404
69Retinol metabolism_Homo sapiens_hsa008301.27222619
70Selenocompound metabolism_Homo sapiens_hsa004501.26657367
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22349295
72Tyrosine metabolism_Homo sapiens_hsa003501.21583091
73Fat digestion and absorption_Homo sapiens_hsa049751.19678945
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14708527
75* Salmonella infection_Homo sapiens_hsa051321.13761545
76Type I diabetes mellitus_Homo sapiens_hsa049401.12912138
77Cysteine and methionine metabolism_Homo sapiens_hsa002701.12603658
78* Phagosome_Homo sapiens_hsa041451.12351311
79Sulfur metabolism_Homo sapiens_hsa009201.11492083
80Antigen processing and presentation_Homo sapiens_hsa046121.06086966
81Herpes simplex infection_Homo sapiens_hsa051681.05326560
82ABC transporters_Homo sapiens_hsa020101.05187522
83Arginine and proline metabolism_Homo sapiens_hsa003301.03357880
84Jak-STAT signaling pathway_Homo sapiens_hsa046301.02612485
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02512386
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01199117
87Chemokine signaling pathway_Homo sapiens_hsa040620.99252664
88Hepatitis C_Homo sapiens_hsa051600.98581173
89Measles_Homo sapiens_hsa051620.96375644
90Folate biosynthesis_Homo sapiens_hsa007900.95828789
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94700948
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91819201
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91043384
94Lysine degradation_Homo sapiens_hsa003100.90778416
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88547403
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87390033
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87191572
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86869858
99Shigellosis_Homo sapiens_hsa051310.85020740
100Apoptosis_Homo sapiens_hsa042100.84246768
101Platelet activation_Homo sapiens_hsa046110.84078771
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78940613
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77495303
104Bladder cancer_Homo sapiens_hsa052190.77176506
105Sulfur relay system_Homo sapiens_hsa041220.75065175
106Primary immunodeficiency_Homo sapiens_hsa053400.71908584
107Collecting duct acid secretion_Homo sapiens_hsa049660.71679465
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71544361
109Fatty acid biosynthesis_Homo sapiens_hsa000610.71080156
110Glycerolipid metabolism_Homo sapiens_hsa005610.69518963
111VEGF signaling pathway_Homo sapiens_hsa043700.68176128
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.67997762
113Vitamin digestion and absorption_Homo sapiens_hsa049770.67553154
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66016071
115Hepatitis B_Homo sapiens_hsa051610.65183259
116Vitamin B6 metabolism_Homo sapiens_hsa007500.63933238
117Insulin resistance_Homo sapiens_hsa049310.63265580
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.63240526
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63020040
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.62428196
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61986313
122Steroid biosynthesis_Homo sapiens_hsa001000.61716805
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61704141
124Cardiac muscle contraction_Homo sapiens_hsa042600.58875888
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57693993
126Pentose phosphate pathway_Homo sapiens_hsa000300.57358798
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.55714912
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54680324
129Glutathione metabolism_Homo sapiens_hsa004800.53410844
130Galactose metabolism_Homo sapiens_hsa000520.52430868
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51539674
132Mineral absorption_Homo sapiens_hsa049780.50557162
133T cell receptor signaling pathway_Homo sapiens_hsa046600.49876717
134Fructose and mannose metabolism_Homo sapiens_hsa000510.49044478
135Pancreatic cancer_Homo sapiens_hsa052120.48769107
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48346721
137Chronic myeloid leukemia_Homo sapiens_hsa052200.47663869
138Metabolic pathways_Homo sapiens_hsa011000.45879738
139Dilated cardiomyopathy_Homo sapiens_hsa054140.45326983
140Prolactin signaling pathway_Homo sapiens_hsa049170.44958094
141Oxidative phosphorylation_Homo sapiens_hsa001900.42329825
142HIF-1 signaling pathway_Homo sapiens_hsa040660.41877821
143Renin-angiotensin system_Homo sapiens_hsa046140.41255309
144Glucagon signaling pathway_Homo sapiens_hsa049220.41075565
145Parkinsons disease_Homo sapiens_hsa050120.40283320
146Endocytosis_Homo sapiens_hsa041440.39879150
147Epstein-Barr virus infection_Homo sapiens_hsa051690.37180842
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.33246803
149AMPK signaling pathway_Homo sapiens_hsa041520.32629994
150Non-small cell lung cancer_Homo sapiens_hsa052230.32097985
151Sphingolipid metabolism_Homo sapiens_hsa006000.30705580
152Alzheimers disease_Homo sapiens_hsa050100.26980975
153Insulin signaling pathway_Homo sapiens_hsa049100.26432849
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19435465
155Prion diseases_Homo sapiens_hsa050200.18874689
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17704937
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.16297047
158One carbon pool by folate_Homo sapiens_hsa006700.14508337
159Linoleic acid metabolism_Homo sapiens_hsa005910.08838821
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04692085
161Central carbon metabolism in cancer_Homo sapiens_hsa052300.04545663
162Huntingtons disease_Homo sapiens_hsa050160.01472654
163Regulation of autophagy_Homo sapiens_hsa04140-0.1415975
164Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1214477
165Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1198835
166Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.1104449
167Circadian rhythm_Homo sapiens_hsa04710-0.0914352
168Amoebiasis_Homo sapiens_hsa05146-0.0752604
169Viral myocarditis_Homo sapiens_hsa05416-0.0563542
170Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0538208
171Type II diabetes mellitus_Homo sapiens_hsa04930-0.0415080
172Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0172343

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