RILPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.75863741
2actin-myosin filament sliding (GO:0033275)7.12431375
3muscle filament sliding (GO:0030049)7.12431375
4cardiac myofibril assembly (GO:0055003)6.99987551
5myofibril assembly (GO:0030239)6.84648646
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.77080187
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.58468110
8regulation of skeletal muscle contraction (GO:0014819)6.44356171
9plasma membrane repair (GO:0001778)6.41767674
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.09080839
11negative regulation of potassium ion transmembrane transport (GO:1901380)5.90886089
12sarcoplasmic reticulum calcium ion transport (GO:0070296)5.90691288
13actin-mediated cell contraction (GO:0070252)5.87099540
14cardiac muscle contraction (GO:0060048)5.62669370
15regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.59905314
16regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.55247233
17behavioral response to nicotine (GO:0035095)5.50689672
18regulation of cell communication by electrical coupling (GO:0010649)5.32675840
19regulation of relaxation of muscle (GO:1901077)5.22328039
20actomyosin structure organization (GO:0031032)5.18505594
21regulation of actin filament-based movement (GO:1903115)5.16266269
22regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.09903928
23regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.08821255
24striated muscle contraction (GO:0006941)5.03429828
25cardiac muscle cell development (GO:0055013)4.89772266
26tricarboxylic acid cycle (GO:0006099)4.83423667
27cardiac cell development (GO:0055006)4.58886239
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.57956675
29actin filament-based movement (GO:0030048)4.49534948
30skeletal muscle contraction (GO:0003009)4.48562093
31regulation of membrane repolarization (GO:0060306)4.43337246
32regulation of sarcomere organization (GO:0060297)4.42078430
33cardiac muscle hypertrophy (GO:0003300)4.39899054
34ventricular cardiac muscle cell action potential (GO:0086005)4.39639132
35adult heart development (GO:0007512)4.39033384
36response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.37468092
37regulation of striated muscle contraction (GO:0006942)4.36124999
38cardiac muscle tissue morphogenesis (GO:0055008)4.34806539
39regulation of acyl-CoA biosynthetic process (GO:0050812)4.33827015
40striated muscle hypertrophy (GO:0014897)4.26110766
41carnitine shuttle (GO:0006853)4.19620297
42heart trabecula formation (GO:0060347)4.12300611
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.09620152
44positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.05484472
45ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.04486037
46creatine metabolic process (GO:0006600)4.00772380
47muscle tissue morphogenesis (GO:0060415)3.98925902
48regulation of coenzyme metabolic process (GO:0051196)3.97988169
49regulation of cofactor metabolic process (GO:0051193)3.97988169
50regulation of calcium ion transmembrane transport (GO:1903169)3.81795127
51regulation of calcium ion transmembrane transporter activity (GO:1901019)3.81795127
52cell communication involved in cardiac conduction (GO:0086065)3.72979786
53cell communication by electrical coupling (GO:0010644)3.67676151
54muscle hypertrophy (GO:0014896)3.67389380
55regulation of the force of heart contraction (GO:0002026)3.66771814
56skeletal muscle adaptation (GO:0043501)3.66470508
57muscle contraction (GO:0006936)3.65617397
58response to inactivity (GO:0014854)3.59739932
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59737863
60heart contraction (GO:0060047)3.59064701
61heart process (GO:0003015)3.59064701
62negative regulation of potassium ion transport (GO:0043267)3.56748066
63bundle of His cell to Purkinje myocyte communication (GO:0086069)3.54239931
64negative regulation of protein localization to cell surface (GO:2000009)3.52413315
65regulation of cardiac muscle cell contraction (GO:0086004)3.52171877
66positive regulation of cation channel activity (GO:2001259)3.49750584
67regulation of cardiac muscle contraction (GO:0055117)3.49682799
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48076112
69fatty acid transmembrane transport (GO:1902001)3.47645801
70cardiac muscle cell action potential (GO:0086001)3.46251388
71cardiac muscle cell action potential involved in contraction (GO:0086002)3.44875861
72neuronal action potential propagation (GO:0019227)3.39732193
73muscle system process (GO:0003012)3.37493318
74striated muscle adaptation (GO:0014888)3.36500522
75cardiac muscle hypertrophy in response to stress (GO:0014898)3.35044181
76muscle hypertrophy in response to stress (GO:0003299)3.35044181
77cardiac muscle adaptation (GO:0014887)3.35044181
78regulation of heart rate (GO:0002027)3.29584222
79negative regulation of cytosolic calcium ion concentration (GO:0051481)3.28867269
80membrane depolarization during action potential (GO:0086010)3.27314555
81regulation of sulfur metabolic process (GO:0042762)3.25125587
82striated muscle cell development (GO:0055002)3.24441977
83respiratory electron transport chain (GO:0022904)3.23130825
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20897935
85neuronal action potential (GO:0019228)3.19371849
86regulation of action potential (GO:0098900)3.17754420
87regulation of heart contraction (GO:0008016)3.16405735
88cardiac conduction (GO:0061337)3.16196448
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16194649
90fucose catabolic process (GO:0019317)3.13728856
91L-fucose metabolic process (GO:0042354)3.13728856
92L-fucose catabolic process (GO:0042355)3.13728856
93electron transport chain (GO:0022900)3.12962196
94gamma-aminobutyric acid transport (GO:0015812)3.11837295
95relaxation of cardiac muscle (GO:0055119)3.10227773
96positive regulation of heart rate (GO:0010460)3.09405454
97negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.08612678
98postsynaptic membrane organization (GO:0001941)3.08121803
99glycogen catabolic process (GO:0005980)3.07769442
100detection of calcium ion (GO:0005513)3.06830904
101NADH metabolic process (GO:0006734)3.06629661
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06454493
103response to muscle activity (GO:0014850)3.06366742
104regulation of cation channel activity (GO:2001257)3.06186848
105muscle cell cellular homeostasis (GO:0046716)3.05693377
106energy coupled proton transport, down electrochemical gradient (GO:0015985)3.04758361
107ATP synthesis coupled proton transport (GO:0015986)3.04758361
108positive regulation of heart contraction (GO:0045823)3.02730566
109kynurenine metabolic process (GO:0070189)3.00691875
110detection of light stimulus involved in sensory perception (GO:0050962)3.00370293
111detection of light stimulus involved in visual perception (GO:0050908)3.00370293
112carnitine transmembrane transport (GO:1902603)2.99448535
113regulation of ATP catabolic process (GO:1903289)2.99335619
114regulation of ATPase activity (GO:0043462)2.99335619
115muscle fiber development (GO:0048747)2.98374616
116neuromuscular synaptic transmission (GO:0007274)2.92530273
117cellular response to ATP (GO:0071318)2.91965698
118synaptic transmission, cholinergic (GO:0007271)2.79533609
119positive regulation of sodium ion transmembrane transport (GO:1902307)2.75226569
120indole-containing compound catabolic process (GO:0042436)2.73170334
121indolalkylamine catabolic process (GO:0046218)2.73170334
122tryptophan catabolic process (GO:0006569)2.73170334
123action potential (GO:0001508)2.72053502
124startle response (GO:0001964)2.71246336
125indolalkylamine metabolic process (GO:0006586)2.68143443
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.67734755
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66167557
128behavioral response to ethanol (GO:0048149)2.64681887
129cellular ketone body metabolic process (GO:0046950)2.63703903
130cAMP catabolic process (GO:0006198)2.63614331
131primary amino compound metabolic process (GO:1901160)2.61592324
132protein polyglutamylation (GO:0018095)2.60770185
133positive regulation of fatty acid oxidation (GO:0046321)2.59390175
134serotonin metabolic process (GO:0042428)2.56319450
135positive regulation of action potential (GO:0045760)2.56236177
136regulation of hippo signaling (GO:0035330)2.55388891
137cornea development in camera-type eye (GO:0061303)2.54907175
138auditory receptor cell stereocilium organization (GO:0060088)2.54790290
139axon ensheathment in central nervous system (GO:0032291)2.52416110
140central nervous system myelination (GO:0022010)2.52416110
141cyclic nucleotide catabolic process (GO:0009214)2.48167552
142transmission of nerve impulse (GO:0019226)2.47799139
143epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45713756
144nephron tubule morphogenesis (GO:0072078)2.44156825
145nephron epithelium morphogenesis (GO:0072088)2.44156825
146inner ear receptor stereocilium organization (GO:0060122)2.42288606
147somite development (GO:0061053)2.39441595
148sulfation (GO:0051923)2.38482271
149positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.38384908
150positive regulation of meiosis (GO:0045836)2.36015343
151nonmotile primary cilium assembly (GO:0035058)2.35844042
152indole-containing compound metabolic process (GO:0042430)2.34966458
153ketone body metabolic process (GO:1902224)2.33519493
154otic vesicle formation (GO:0030916)2.33032129
155negative regulation of reactive oxygen species metabolic process (GO:2000378)2.32590722
156negative regulation of mast cell activation (GO:0033004)2.32366217
157glycerophospholipid catabolic process (GO:0046475)2.30814417
158regulation of neurotransmitter uptake (GO:0051580)2.29594351
159regulation of hexokinase activity (GO:1903299)2.28681187
160regulation of glucokinase activity (GO:0033131)2.28681187
161response to pheromone (GO:0019236)2.27977690
162interkinetic nuclear migration (GO:0022027)2.27751617
163positive regulation of sodium ion transport (GO:0010765)2.27313064
164reflex (GO:0060004)2.27064974
165piRNA metabolic process (GO:0034587)2.26482118
166retinal cone cell development (GO:0046549)2.25484277
167auditory behavior (GO:0031223)2.23676485
168spinal cord motor neuron differentiation (GO:0021522)2.23586104
169regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.22902019
170C4-dicarboxylate transport (GO:0015740)2.22759757
171kidney morphogenesis (GO:0060993)2.22128291
172multicellular organismal signaling (GO:0035637)2.21946761
173axoneme assembly (GO:0035082)2.20498953
174spinal cord development (GO:0021510)2.19341544
175glutamate receptor signaling pathway (GO:0007215)2.19273471
176synaptic transmission, glutamatergic (GO:0035249)2.18135252
177regulation of rhodopsin mediated signaling pathway (GO:0022400)2.18071712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.01208343
2EP300_21415370_ChIP-Seq_HL-1_Mouse3.40594518
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.25149318
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.12098307
5VDR_22108803_ChIP-Seq_LS180_Human2.76018946
6TBX20_22080862_ChIP-Seq_HEART_Mouse2.74522848
7TBX20_22328084_ChIP-Seq_HEART_Mouse2.74522848
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68077103
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60572799
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.47977095
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30935009
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26084855
13ZNF263_19887448_ChIP-Seq_K562_Human2.26044120
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16054294
15DROSHA_22980978_ChIP-Seq_HELA_Human2.14401069
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07029187
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01575886
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00869517
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00869517
20MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.99607961
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94120380
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91636589
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.90312859
24IGF1R_20145208_ChIP-Seq_DFB_Human1.86735930
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86611875
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86135861
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85700460
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83285176
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78099619
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74897775
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74715730
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.74521833
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.73977062
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71754089
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71580300
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.70898702
37REST_21632747_ChIP-Seq_MESCs_Mouse1.69348972
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68470709
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66894467
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61012773
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60976204
42P300_19829295_ChIP-Seq_ESCs_Human1.59933377
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.59632520
44TAF15_26573619_Chip-Seq_HEK293_Human1.56558583
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56481986
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54950883
47ER_23166858_ChIP-Seq_MCF-7_Human1.53801728
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52841923
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51450953
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50933614
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49698613
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49360405
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49035609
54* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47237735
55STAT3_23295773_ChIP-Seq_U87_Human1.46425127
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.46222289
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.44165230
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43294843
59FUS_26573619_Chip-Seq_HEK293_Human1.43011365
60BCAT_22108803_ChIP-Seq_LS180_Human1.42330664
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42185419
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41124522
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41124522
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40499627
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40258066
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.38328826
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38227683
68* TCF4_23295773_ChIP-Seq_U87_Human1.37813831
69EWS_26573619_Chip-Seq_HEK293_Human1.36366744
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36053135
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.35679492
72RNF2_27304074_Chip-Seq_NSC_Mouse1.34758667
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.34649907
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33619021
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32430120
76ZNF274_21170338_ChIP-Seq_K562_Hela1.32266586
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.31958030
78AR_25329375_ChIP-Seq_VCAP_Human1.31166789
79* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30554241
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29608009
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28442883
82* AR_21572438_ChIP-Seq_LNCaP_Human1.28169968
83* CTCF_27219007_Chip-Seq_Bcells_Human1.27061630
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26349714
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26127680
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25144014
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.24974885
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23424806
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22599928
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21781074
91GBX2_23144817_ChIP-Seq_PC3_Human1.19406936
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19332267
93KDM2B_26808549_Chip-Seq_K562_Human1.18868610
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18693951
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18389676
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17649828
97GATA4_21415370_ChIP-Seq_HL-1_Mouse1.16552785
98CBP_20019798_ChIP-Seq_JUKART_Human1.15631466
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15631466
100KDM2B_26808549_Chip-Seq_DND41_Human1.15370603
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14863351
102CLOCK_20551151_ChIP-Seq_293T_Human1.14429022
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12729625
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.10897591
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09702912
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09556541
107TP53_16413492_ChIP-PET_HCT116_Human1.06872167
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06830777
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.06417060
110RUNX2_22187159_ChIP-Seq_PCA_Human1.05807769
111SMAD3_21741376_ChIP-Seq_HESCs_Human1.05444742
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05332164
113LXR_22292898_ChIP-Seq_THP-1_Human1.04584093
114TCF4_22108803_ChIP-Seq_LS180_Human1.04049685
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03575182
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03436088
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.03316548
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03119023
119TP53_22573176_ChIP-Seq_HFKS_Human1.02972901
120NANOG_19829295_ChIP-Seq_ESCs_Human1.02627422
121SOX2_19829295_ChIP-Seq_ESCs_Human1.02627422
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02242943
123AHR_22903824_ChIP-Seq_MCF-7_Human1.01927127
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01759177
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01205723
126ISL1_27105846_Chip-Seq_CPCs_Mouse1.00734499
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00476447
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99617335
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.99492948
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99166807
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.98593757
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97739078
133REST_18959480_ChIP-ChIP_MESCs_Mouse0.97654014
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97076405
135PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96444268
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95213557
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95014763
138TP53_20018659_ChIP-ChIP_R1E_Mouse0.94865712
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.94824925
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.94199846
141GATA3_21878914_ChIP-Seq_MCF-7_Human0.93840516
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93498361
143HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93489363
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93044542
145TP53_23651856_ChIP-Seq_MEFs_Mouse0.92659904
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92058811
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.92015685
148DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91719996
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.91394497
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90874540
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90731868
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89885977
153AR_19668381_ChIP-Seq_PC3_Human0.88076724
154SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86716173
155ELK3_25401928_ChIP-Seq_HUVEC_Human0.86675140
156NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85833049
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85833049
158TP63_22573176_ChIP-Seq_HFKS_Human0.85315374
159NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84695390
160TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84688506
161PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84495578
162KLF4_19829295_ChIP-Seq_ESCs_Human0.83589411
163ERG_21242973_ChIP-ChIP_JURKAT_Human0.83282421
164SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82717330
165SMAD4_21799915_ChIP-Seq_A2780_Human0.81359413
166GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81092365
167UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80620553
168ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79204821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.97009134
2MP0000751_myopathy5.38062706
3MP0003646_muscle_fatigue5.32801123
4MP0004084_abnormal_cardiac_muscle4.61504781
5MP0000749_muscle_degeneration4.46811704
6MP0004036_abnormal_muscle_relaxation4.01666738
7MP0004215_abnormal_myocardial_fiber3.99105860
8MP0004145_abnormal_muscle_electrophysio3.78837237
9MP0005330_cardiomyopathy3.30491581
10MP0004087_abnormal_muscle_fiber3.08728321
11MP0000750_abnormal_muscle_regeneration2.85033102
12MP0002106_abnormal_muscle_physiology2.81500944
13MP0005620_abnormal_muscle_contractility2.72502679
14MP0000747_muscle_weakness2.67836536
15MP0002972_abnormal_cardiac_muscle2.62632784
16MP0002269_muscular_atrophy2.53659405
17MP0004130_abnormal_muscle_cell2.52112741
18MP0000759_abnormal_skeletal_muscle2.41935143
19MP0003137_abnormal_impulse_conducting2.40930669
20MP0004484_altered_response_of2.40836237
21MP0001968_abnormal_touch/_nociception2.39108521
22MP0005369_muscle_phenotype2.36737402
23MP0008775_abnormal_heart_ventricle2.18550953
24MP0010630_abnormal_cardiac_muscle2.15605919
25MP0000569_abnormal_digit_pigmentation2.15580312
26MP0001544_abnormal_cardiovascular_syste2.11887420
27MP0005385_cardiovascular_system_phenoty2.11887420
28MP0005551_abnormal_eye_electrophysiolog2.11633583
29MP0004233_abnormal_muscle_weight2.07313167
30MP0002638_abnormal_pupillary_reflex2.04167736
31MP0006138_congestive_heart_failure1.99136993
32MP0003136_yellow_coat_color1.90012989
33MP0004085_abnormal_heartbeat1.84617056
34MP0002736_abnormal_nociception_after1.83433245
35MP0004142_abnormal_muscle_tone1.80707059
36MP0004885_abnormal_endolymph1.72698466
37MP0005646_abnormal_pituitary_gland1.72097549
38MP0005423_abnormal_somatic_nervous1.66731139
39MP0004510_myositis1.62728710
40MP0003828_pulmonary_edema1.61642155
41MP0001486_abnormal_startle_reflex1.61443746
42MP0001986_abnormal_taste_sensitivity1.59230605
43MP0006276_abnormal_autonomic_nervous1.56303800
44MP0002735_abnormal_chemical_nociception1.55773365
45MP0004859_abnormal_synaptic_plasticity1.55136807
46MP0002332_abnormal_exercise_endurance1.49087566
47MP0002876_abnormal_thyroid_physiology1.48380211
48MP0002572_abnormal_emotion/affect_behav1.47206831
49MP0003221_abnormal_cardiomyocyte_apopto1.46596918
50MP0003195_calcinosis1.46245306
51MP0006292_abnormal_olfactory_placode1.46207550
52MP0002653_abnormal_ependyma_morphology1.40045000
53MP0005666_abnormal_adipose_tissue1.39527991
54MP0003950_abnormal_plasma_membrane1.38357946
55MP0006036_abnormal_mitochondrial_physio1.38202894
56MP0003787_abnormal_imprinting1.36695171
57MP0001970_abnormal_pain_threshold1.34794852
58MP0002734_abnormal_mechanical_nocicepti1.32474283
59MP0002127_abnormal_cardiovascular_syste1.32056399
60MP0002102_abnormal_ear_morphology1.31882399
61MP0001501_abnormal_sleep_pattern1.31696607
62MP0005623_abnormal_meninges_morphology1.30629060
63MP0003283_abnormal_digestive_organ1.30428511
64MP0002733_abnormal_thermal_nociception1.29898028
65MP0008872_abnormal_physiological_respon1.29864702
66MP0001485_abnormal_pinna_reflex1.29547146
67MP0002108_abnormal_muscle_morphology1.29235835
68MP0001502_abnormal_circadian_rhythm1.27026164
69MP0000427_abnormal_hair_cycle1.25530525
70MP0002557_abnormal_social/conspecific_i1.20518767
71MP0006072_abnormal_retinal_apoptosis1.17371561
72MP0008877_abnormal_DNA_methylation1.16556883
73MP0005253_abnormal_eye_physiology1.15945185
74MP0000778_abnormal_nervous_system1.14061796
75MP0004133_heterotaxia1.13666994
76MP0004185_abnormal_adipocyte_glucose1.13647994
77MP0000631_abnormal_neuroendocrine_gland1.10879915
78MP0010368_abnormal_lymphatic_system1.09693690
79MP0000733_abnormal_muscle_development1.09661767
80MP0005670_abnormal_white_adipose1.09257584
81MP0003011_delayed_dark_adaptation1.07865884
82MP0001984_abnormal_olfaction1.07702589
83MP0004270_analgesia1.07596223
84MP0005375_adipose_tissue_phenotype1.07483740
85MP0000013_abnormal_adipose_tissue1.06983977
86MP0005171_absent_coat_pigmentation1.04186796
87MP0002234_abnormal_pharynx_morphology1.03517633
88MP0003279_aneurysm1.03447095
89MP0005174_abnormal_tail_pigmentation1.03046583
90MP0002938_white_spotting1.02122247
91MP0002160_abnormal_reproductive_system1.01351096
92MP0002184_abnormal_innervation1.00179635
93MP0000266_abnormal_heart_morphology0.98002112
94MP0005165_increased_susceptibility_to0.96765712
95MP0005645_abnormal_hypothalamus_physiol0.95417380
96MP0000343_altered_response_to0.95004937
97MP0002752_abnormal_somatic_nervous0.93851404
98MP0003879_abnormal_hair_cell0.89254798
99MP0000026_abnormal_inner_ear0.88552072
100MP0005195_abnormal_posterior_eye0.88278115
101MP0002909_abnormal_adrenal_gland0.86953424
102MP0000955_abnormal_spinal_cord0.84131941
103MP0004742_abnormal_vestibular_system0.83961560
104MP0008438_abnormal_cutaneous_collagen0.83894901
105MP0002882_abnormal_neuron_morphology0.83838207
106MP0003567_abnormal_fetal_cardiomyocyte0.82747838
107MP0004272_abnormal_basement_membrane0.81443358
108MP0010386_abnormal_urinary_bladder0.80266559
109MP0003119_abnormal_digestive_system0.80089846
110MP0000049_abnormal_middle_ear0.79279004
111MP0009780_abnormal_chondrocyte_physiolo0.78391743
112MP0001963_abnormal_hearing_physiology0.77129237
113MP0003880_abnormal_central_pattern0.76330141
114MP0000230_abnormal_systemic_arterial0.75969560
115MP0004043_abnormal_pH_regulation0.75638820
116MP0003635_abnormal_synaptic_transmissio0.74755263
117MP0003705_abnormal_hypodermis_morpholog0.74696931
118MP0000003_abnormal_adipose_tissue0.74507079
119MP0001879_abnormal_lymphatic_vessel0.72497437
120MP0005167_abnormal_blood-brain_barrier0.71250487
121MP0002128_abnormal_blood_circulation0.69223137
122MP0002971_abnormal_brown_adipose0.63282674
123MP0005266_abnormal_metabolism0.61559370
124MP0006035_abnormal_mitochondrial_morpho0.61058152
125MP0002822_catalepsy0.60792307
126MP0001440_abnormal_grooming_behavior0.60348342
127MP0003045_fibrosis0.59463885
128MP0001299_abnormal_eye_distance/0.57945326
129MP0008569_lethality_at_weaning0.57608309
130MP0004858_abnormal_nervous_system0.56604675
131MP0000767_abnormal_smooth_muscle0.53469805
132MP0002064_seizures0.53180916
133MP0003566_abnormal_cell_adhesion0.52376823
134MP0009745_abnormal_behavioral_response0.52206549
135MP0004924_abnormal_behavior0.49500567
136MP0005386_behavior/neurological_phenoty0.49500567
137MP0002272_abnormal_nervous_system0.48699364
138MP0008961_abnormal_basal_metabolism0.48620555
139MP0005275_abnormal_skin_tensile0.47993467
140MP0002063_abnormal_learning/memory/cond0.46935384
141MP0001958_emphysema0.46414596
142MP0002925_abnormal_cardiovascular_devel0.46169932
143MP0005187_abnormal_penis_morphology0.45260932
144MP0005595_abnormal_vascular_smooth0.45184876
145MP0003633_abnormal_nervous_system0.42541282
146MP0004147_increased_porphyrin_level0.42469304
147MP0008874_decreased_physiological_sensi0.41798938
148MP0002295_abnormal_pulmonary_circulatio0.41567088
149MP0003948_abnormal_gas_homeostasis0.37217199
150MP0002078_abnormal_glucose_homeostasis0.36820051
151MP0005503_abnormal_tendon_morphology0.36730753
152MP0005535_abnormal_body_temperature0.36511226
153MP0009046_muscle_twitch0.35895978
154MP0002066_abnormal_motor_capabilities/c0.35310339
155MP0001614_abnormal_blood_vessel0.34786650
156MP0002067_abnormal_sensory_capabilities0.34102255

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)6.76711673
2Sudden death (HP:0001699)6.72260253
3Exercise-induced myalgia (HP:0003738)6.64584608
4Muscle hypertrophy of the lower extremities (HP:0008968)6.58578479
5Exercise-induced muscle cramps (HP:0003710)6.46322848
6Muscle fiber splitting (HP:0003555)5.86926878
7Ventricular tachycardia (HP:0004756)5.47706365
8Abnormality of the calf musculature (HP:0001430)5.41669907
9Hyporeflexia of lower limbs (HP:0002600)5.22683300
10Atrial fibrillation (HP:0005110)4.77786153
11EMG: myopathic abnormalities (HP:0003458)4.74925770
12Myoglobinuria (HP:0002913)4.69500715
13Muscle fiber inclusion bodies (HP:0100299)4.60660710
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.54172217
15Abnormality of the left ventricular outflow tract (HP:0011103)4.49192805
16Subaortic stenosis (HP:0001682)4.49192805
17Primary atrial arrhythmia (HP:0001692)4.48784337
18Difficulty running (HP:0009046)4.42457990
19Increased connective tissue (HP:0009025)4.36290701
20Supraventricular tachycardia (HP:0004755)4.31270895
21Supraventricular arrhythmia (HP:0005115)4.24623687
22Bundle branch block (HP:0011710)4.15009196
23Lipoatrophy (HP:0100578)4.14158380
24Type 1 muscle fiber predominance (HP:0003803)4.10954802
25Congenital stationary night blindness (HP:0007642)4.06890232
26Myotonia (HP:0002486)3.94032305
27Pancreatic cysts (HP:0001737)3.86198114
28Nemaline bodies (HP:0003798)3.85212483
29Asymmetric septal hypertrophy (HP:0001670)3.81018178
30Right ventricular cardiomyopathy (HP:0011663)3.77922324
31Syncope (HP:0001279)3.73039121
32Abnormality of midbrain morphology (HP:0002418)3.64796634
33Molar tooth sign on MRI (HP:0002419)3.64796634
34Pancreatic fibrosis (HP:0100732)3.64184156
35Difficulty climbing stairs (HP:0003551)3.54009550
36Dilated cardiomyopathy (HP:0001644)3.52804104
37Prolonged QT interval (HP:0001657)3.47700709
38True hermaphroditism (HP:0010459)3.46172018
39Rhabdomyolysis (HP:0003201)3.42802673
40Nephronophthisis (HP:0000090)3.42758665
41Genetic anticipation (HP:0003743)3.42411068
42Hyperventilation (HP:0002883)3.37970890
43Increased variability in muscle fiber diameter (HP:0003557)3.28921735
44Heart block (HP:0012722)3.27513523
45Palpitations (HP:0001962)3.26649500
46Ventricular arrhythmia (HP:0004308)3.23223324
47Abnormality of skeletal muscle fiber size (HP:0012084)3.18343657
48Abnormal atrioventricular conduction (HP:0005150)3.10952870
49Type II lissencephaly (HP:0007260)3.09575131
50Muscle stiffness (HP:0003552)3.08057823
51Round ear (HP:0100830)3.02930301
52Distal arthrogryposis (HP:0005684)3.02326556
53Progressive cerebellar ataxia (HP:0002073)3.01477671
54Abnormality of the renal medulla (HP:0100957)2.97415518
55Abnormality of the renal cortex (HP:0011035)2.94542360
56Ventricular fibrillation (HP:0001663)2.94082374
57Atrioventricular block (HP:0001678)2.92735875
58Abnormality of alanine metabolism (HP:0010916)2.90128231
59Hyperalaninemia (HP:0003348)2.90128231
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.90128231
61Neck muscle weakness (HP:0000467)2.84376719
62Attenuation of retinal blood vessels (HP:0007843)2.73315240
63Tubular atrophy (HP:0000092)2.68359641
64Cystic liver disease (HP:0006706)2.67594042
65Distal lower limb muscle weakness (HP:0009053)2.66213821
66Abnormal EKG (HP:0003115)2.61654471
67Limb-girdle muscle atrophy (HP:0003797)2.61245726
68Gaze-evoked nystagmus (HP:0000640)2.60491494
69Myopathic facies (HP:0002058)2.60450457
70Febrile seizures (HP:0002373)2.59813389
71Increased corneal curvature (HP:0100692)2.57321557
72Keratoconus (HP:0000563)2.57321557
73Abnormal drinking behavior (HP:0030082)2.55137275
74Polydipsia (HP:0001959)2.55137275
75Areflexia of lower limbs (HP:0002522)2.54288224
76Left ventricular hypertrophy (HP:0001712)2.51213628
77Distal lower limb amyotrophy (HP:0008944)2.47880987
78Rimmed vacuoles (HP:0003805)2.47761327
79Pendular nystagmus (HP:0012043)2.45436481
80Focal seizures (HP:0007359)2.44349534
81Mildly elevated creatine phosphokinase (HP:0008180)2.44128178
82Focal motor seizures (HP:0011153)2.44097094
83Broad-based gait (HP:0002136)2.37156723
84Chorioretinal atrophy (HP:0000533)2.36904597
85Scapular winging (HP:0003691)2.36040415
86Testicular atrophy (HP:0000029)2.35620883
87Muscular dystrophy (HP:0003560)2.34466603
88Abnormal mitochondria in muscle tissue (HP:0008316)2.34005066
89Gowers sign (HP:0003391)2.33941561
90Medial flaring of the eyebrow (HP:0010747)2.33107691
91Acute necrotizing encephalopathy (HP:0006965)2.32958238
92Chronic hepatic failure (HP:0100626)2.30767756
93Hemiparesis (HP:0001269)2.29028246
94EMG: neuropathic changes (HP:0003445)2.20590696
95Abnormal rod and cone electroretinograms (HP:0008323)2.19468901
96Cerebellar dysplasia (HP:0007033)2.19314934
97Sclerocornea (HP:0000647)2.19260341
98Abolished electroretinogram (ERG) (HP:0000550)2.19092856
99Protruding tongue (HP:0010808)2.15357580
100Abnormality of the foot musculature (HP:0001436)2.14807085
101Clumsiness (HP:0002312)2.13431727
102Foot dorsiflexor weakness (HP:0009027)2.13218525
103Inability to walk (HP:0002540)2.12750794
104Hypoplastic ischia (HP:0003175)2.12541827
105Centrally nucleated skeletal muscle fibers (HP:0003687)2.12184751
106Lissencephaly (HP:0001339)2.10624517
107Proximal amyotrophy (HP:0007126)2.10180313
108Lower limb amyotrophy (HP:0007210)2.09576323
109Frequent falls (HP:0002359)2.08644967
110Decreased central vision (HP:0007663)2.07963363
111Generalized muscle weakness (HP:0003324)2.06907529
112Pheochromocytoma (HP:0002666)2.05526327
113Spinal rigidity (HP:0003306)2.04866994
114Ulnar deviation of the wrist (HP:0003049)2.04354795
115Severe muscular hypotonia (HP:0006829)2.03220901
116Limb-girdle muscle weakness (HP:0003325)2.02442632
117Hepatic necrosis (HP:0002605)2.00945977
118Palmoplantar keratoderma (HP:0000982)2.00295661
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.99806228
120Anencephaly (HP:0002323)1.99378774
121Broad metatarsal (HP:0001783)1.98491726
122Pachygyria (HP:0001302)1.97138879
123Progressive macrocephaly (HP:0004481)1.96759031
124Facial diplegia (HP:0001349)1.96625604
125Congenital hepatic fibrosis (HP:0002612)1.96337126
126Renal cortical cysts (HP:0000803)1.95452765
127Ketoacidosis (HP:0001993)1.94799338
128Concave nail (HP:0001598)1.94709069
129Dialeptic seizures (HP:0011146)1.94655332
130Decreased circulating renin level (HP:0003351)1.94466198
131Polyuria (HP:0000103)1.92865624
132Rapidly progressive (HP:0003678)1.91087912
133Bony spicule pigmentary retinopathy (HP:0007737)1.90685027
134Hepatocellular necrosis (HP:0001404)1.90508567
135Patellar aplasia (HP:0006443)1.89712145
136Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89182033
137Rib fusion (HP:0000902)1.87573622
138Acute encephalopathy (HP:0006846)1.87527806
139Gait imbalance (HP:0002141)1.87007842
140Optic nerve hypoplasia (HP:0000609)1.86587194
141Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86120480
142Furrowed tongue (HP:0000221)1.85572388
143Aplasia/Hypoplasia of the patella (HP:0006498)1.85362325
144Congenital sensorineural hearing impairment (HP:0008527)1.83945541
145Bulbous nose (HP:0000414)1.83304318
146Neuroendocrine neoplasm (HP:0100634)1.81834169
147Abnormality of the ischium (HP:0003174)1.81417647
148Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81162370
149Dysmetric saccades (HP:0000641)1.80912784
150Mitochondrial inheritance (HP:0001427)1.80399033
151Calcaneovalgus deformity (HP:0001848)1.78227300
152Abnormality of the shoulder girdle musculature (HP:0001435)1.77527660
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.77523532
154Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77386048
155Tachypnea (HP:0002789)1.77215793
156Exercise intolerance (HP:0003546)1.76316808
157Absent speech (HP:0001344)1.74925993
158Atonic seizures (HP:0010819)1.72998350
159Congenital, generalized hypertrichosis (HP:0004540)1.70459850
160Congestive heart failure (HP:0001635)1.68703518
161Epileptic encephalopathy (HP:0200134)1.68630153
162Absence seizures (HP:0002121)1.67862924
163Dynein arm defect of respiratory motile cilia (HP:0012255)1.67560946
164Absent/shortened dynein arms (HP:0200106)1.67560946
165Hip contracture (HP:0003273)1.66980525
166Large for gestational age (HP:0001520)1.66095836
167Sudden cardiac death (HP:0001645)1.64269662
168Increased muscle lipid content (HP:0009058)1.64015273
169Bulbar palsy (HP:0001283)1.63696143
170Conjunctival hamartoma (HP:0100780)1.63607588
171Increased CSF lactate (HP:0002490)1.63308351
172Absent phalangeal crease (HP:0006109)1.61004313
173Hamartoma of the eye (HP:0010568)1.60544270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.91225597
2FRK5.49014353
3OBSCN4.63929257
4PHKG24.56623331
5PHKG14.56623331
6DMPK2.95116342
7ADRBK22.85889521
8LMTK22.84609457
9TRIB32.55627537
10PDK32.55090381
11PDK42.55090381
12BMPR1B2.54079396
13MYLK2.48771476
14MARK12.38664454
15MUSK2.29454916
16CASK2.20524282
17GRK12.15180047
18PINK12.00814622
19PKN21.99209835
20ACVR1B1.99042658
21PIK3CA1.97083034
22NEK11.93045901
23WNK31.90123462
24MAPK131.81004796
25TIE11.72503741
26PDK21.71205470
27ZAK1.70813557
28NME11.62611512
29MAP3K71.45610290
30PAK31.45185330
31NUAK11.42869367
32MAP4K21.39992571
33EPHA41.39817885
34TLK11.38097054
35BCKDK1.37211632
36ADRBK11.36913655
37MAPK121.35731887
38PRKD31.22748372
39MAP2K31.22159446
40CAMK2D1.20519366
41PRKD11.12140822
42PRKCG1.10777527
43PTK2B1.10459717
44NTRK21.10175808
45GRK71.05948015
46PAK61.05798860
47OXSR11.05308999
48ILK1.04124476
49MAP2K41.03106656
50NTRK30.97483177
51MAPK150.97327023
52TAOK30.96680614
53PNCK0.95693975
54RIPK10.93481050
55WNK40.91868503
56KSR20.88339870
57STK240.86752452
58PDGFRA0.86491648
59ROCK10.86004602
60AKT30.85350262
61TGFBR10.85241800
62DAPK30.84093474
63DYRK20.81643580
64PKN10.81159475
65WNK10.80444442
66CAMK2A0.78378438
67ROCK20.75308972
68LATS20.74964622
69STK380.73902672
70STK390.73049469
71PRKAA10.70407515
72MAP3K40.70405966
73CAMK40.70034389
74TGFBR20.69680229
75DAPK20.69060804
76FER0.68817348
77CDC42BPA0.68001570
78PRKAA20.67558211
79PDPK10.66837084
80SGK20.65881229
81TNIK0.65599024
82FGFR20.65043093
83MKNK20.63948221
84CAMK10.63514966
85MAPKAPK30.63029303
86MAP3K50.62387415
87SGK2230.62182300
88SGK4940.62182300
89SIK20.62057245
90PIK3CG0.61660916
91LATS10.61439480
92MAP3K90.59837908
93CAMK2G0.59096908
94TXK0.58375501
95TRPM70.58087346
96ICK0.56961668
97PRKCH0.53306745
98PRKACB0.51909640
99RPS6KA60.51386096
100MAPKAPK50.51332738
101CAMKK20.51203026
102PRKCZ0.50177916
103PRKCI0.50003505
104MAP2K60.48082807
105PDK10.47467964
106CAMK1D0.46817658
107RET0.46454613
108PRKCE0.44699138
109EPHB10.44462851
110SGK10.43235967
111MAP3K10.41771228
112MAPK70.40493702
113ERBB20.40051692
114CAMK2B0.39722150
115KDR0.38753951
116CSNK1G20.37799179
117PLK20.37418190
118PRKCQ0.37233840
119PRKCA0.36550836
120STK110.35917804
121PRKACA0.35884809
122KSR10.35379636
123DDR20.35219403
124STK30.34552422
125LIMK10.33695227
126GRK50.33369486
127CAMKK10.33134699
128CSNK1D0.33032434
129AKT20.31228440
130CDK50.30671606
131INSRR0.30224221
132TAOK10.29761463
133RPS6KA30.29702752
134PRKG10.28624940
135MAP2K10.28481895
136PRKACG0.27888726
137STK38L0.25854764
138MARK20.25515189
139CAMK1G0.24093174
140SGK30.23916982
141MAP3K60.22716677
142MINK10.22164568
143EPHB20.21244588
144UHMK10.20154523

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.50545992
2Cardiac muscle contraction_Homo sapiens_hsa042604.05641707
3Dilated cardiomyopathy_Homo sapiens_hsa054143.77070887
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.64784873
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.11307774
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.76358817
7Nitrogen metabolism_Homo sapiens_hsa009102.69042697
8Parkinsons disease_Homo sapiens_hsa050122.67993481
9Oxidative phosphorylation_Homo sapiens_hsa001902.64473635
10Phototransduction_Homo sapiens_hsa047442.60072464
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.37534889
12Linoleic acid metabolism_Homo sapiens_hsa005912.27440452
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23120278
14Alzheimers disease_Homo sapiens_hsa050102.19508833
15Propanoate metabolism_Homo sapiens_hsa006402.17993936
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.17670498
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00323009
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98089534
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88386440
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85087488
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.76142748
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.75160350
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66873908
24Carbon metabolism_Homo sapiens_hsa012001.66274040
25Huntingtons disease_Homo sapiens_hsa050161.59271165
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58736268
27Tryptophan metabolism_Homo sapiens_hsa003801.56613771
28Fatty acid degradation_Homo sapiens_hsa000711.53488535
29Oxytocin signaling pathway_Homo sapiens_hsa049211.50873399
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48810993
31Ether lipid metabolism_Homo sapiens_hsa005651.46281985
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.45024455
33Calcium signaling pathway_Homo sapiens_hsa040201.39403876
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.38918052
35Viral myocarditis_Homo sapiens_hsa054161.34515530
36Glucagon signaling pathway_Homo sapiens_hsa049221.24123428
37Gastric acid secretion_Homo sapiens_hsa049711.22981017
38Fatty acid metabolism_Homo sapiens_hsa012121.22709540
39ABC transporters_Homo sapiens_hsa020101.22398251
40Ovarian steroidogenesis_Homo sapiens_hsa049131.21852165
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20468835
42Sulfur relay system_Homo sapiens_hsa041221.20356962
43Circadian entrainment_Homo sapiens_hsa047131.20343919
44Selenocompound metabolism_Homo sapiens_hsa004501.11449370
45Insulin signaling pathway_Homo sapiens_hsa049101.09746815
46Pyruvate metabolism_Homo sapiens_hsa006201.09498519
47Insulin secretion_Homo sapiens_hsa049111.08781148
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.07860710
49Renin secretion_Homo sapiens_hsa049241.06314884
50Olfactory transduction_Homo sapiens_hsa047401.06139491
51Insulin resistance_Homo sapiens_hsa049311.03359576
52Long-term potentiation_Homo sapiens_hsa047200.99060136
53Focal adhesion_Homo sapiens_hsa045100.97994731
54Histidine metabolism_Homo sapiens_hsa003400.97266006
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95186595
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93296200
57GnRH signaling pathway_Homo sapiens_hsa049120.93050307
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.91195640
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89948361
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88044251
61beta-Alanine metabolism_Homo sapiens_hsa004100.87235423
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87225721
63cAMP signaling pathway_Homo sapiens_hsa040240.86789565
64Type II diabetes mellitus_Homo sapiens_hsa049300.86302834
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84762864
66Tight junction_Homo sapiens_hsa045300.84513896
67Salivary secretion_Homo sapiens_hsa049700.83994772
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83707620
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83277016
70Cholinergic synapse_Homo sapiens_hsa047250.81881071
71HIF-1 signaling pathway_Homo sapiens_hsa040660.81794890
72Arachidonic acid metabolism_Homo sapiens_hsa005900.77765855
73Circadian rhythm_Homo sapiens_hsa047100.77168333
74Gap junction_Homo sapiens_hsa045400.75388982
75Glycerolipid metabolism_Homo sapiens_hsa005610.74747835
76Morphine addiction_Homo sapiens_hsa050320.74551312
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74466903
78Hedgehog signaling pathway_Homo sapiens_hsa043400.72202906
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.72115221
80GABAergic synapse_Homo sapiens_hsa047270.70841421
81Amphetamine addiction_Homo sapiens_hsa050310.69773845
82Regulation of autophagy_Homo sapiens_hsa041400.69657064
83RNA polymerase_Homo sapiens_hsa030200.69173378
84Glutamatergic synapse_Homo sapiens_hsa047240.67914596
85Butanoate metabolism_Homo sapiens_hsa006500.67862816
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67778400
87AMPK signaling pathway_Homo sapiens_hsa041520.67251228
88Starch and sucrose metabolism_Homo sapiens_hsa005000.67166421
89Renal cell carcinoma_Homo sapiens_hsa052110.66677878
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66252489
91Homologous recombination_Homo sapiens_hsa034400.65558507
92VEGF signaling pathway_Homo sapiens_hsa043700.64999857
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64039569
94Biosynthesis of amino acids_Homo sapiens_hsa012300.63526895
95Fatty acid elongation_Homo sapiens_hsa000620.63422559
96Dopaminergic synapse_Homo sapiens_hsa047280.62875641
97Chemical carcinogenesis_Homo sapiens_hsa052040.62502879
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61347630
99Basal transcription factors_Homo sapiens_hsa030220.61233413
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60980716
101Fanconi anemia pathway_Homo sapiens_hsa034600.60238144
102ECM-receptor interaction_Homo sapiens_hsa045120.60048956
103Melanogenesis_Homo sapiens_hsa049160.58166664
104Peroxisome_Homo sapiens_hsa041460.57861572
105Estrogen signaling pathway_Homo sapiens_hsa049150.57770873
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.57697688
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57446250
108Dorso-ventral axis formation_Homo sapiens_hsa043200.56322451
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54034321
110Synaptic vesicle cycle_Homo sapiens_hsa047210.53309958
111Basal cell carcinoma_Homo sapiens_hsa052170.53124513
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52810657
113Caffeine metabolism_Homo sapiens_hsa002320.51915665
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.51043099
115MAPK signaling pathway_Homo sapiens_hsa040100.49790189
116Arginine and proline metabolism_Homo sapiens_hsa003300.49598312
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.48733920
118Adherens junction_Homo sapiens_hsa045200.48513834
119Retinol metabolism_Homo sapiens_hsa008300.46603389
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45870857
121Taste transduction_Homo sapiens_hsa047420.45396126
122Amoebiasis_Homo sapiens_hsa051460.45394214
123Proteoglycans in cancer_Homo sapiens_hsa052050.45175761
124Glioma_Homo sapiens_hsa052140.43524603
125Bile secretion_Homo sapiens_hsa049760.42720003
126Axon guidance_Homo sapiens_hsa043600.42654009
127mTOR signaling pathway_Homo sapiens_hsa041500.42238928
128Rap1 signaling pathway_Homo sapiens_hsa040150.41674842
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41475848
130Mineral absorption_Homo sapiens_hsa049780.41045932
131Fatty acid biosynthesis_Homo sapiens_hsa000610.40884921
132Arginine biosynthesis_Homo sapiens_hsa002200.38969256
133Long-term depression_Homo sapiens_hsa047300.38793138
134Platelet activation_Homo sapiens_hsa046110.38688465
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.38573657
136PPAR signaling pathway_Homo sapiens_hsa033200.37990481
137Thyroid hormone synthesis_Homo sapiens_hsa049180.37459149
138Nicotine addiction_Homo sapiens_hsa050330.37111266
139Hippo signaling pathway_Homo sapiens_hsa043900.36792556
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35565889
141Metabolic pathways_Homo sapiens_hsa011000.35518173
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34493306
143Serotonergic synapse_Homo sapiens_hsa047260.34475773
144Pancreatic secretion_Homo sapiens_hsa049720.34249708
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33646957
146Lysine degradation_Homo sapiens_hsa003100.32174985
147Cocaine addiction_Homo sapiens_hsa050300.29204767
148Fructose and mannose metabolism_Homo sapiens_hsa000510.28316282
149FoxO signaling pathway_Homo sapiens_hsa040680.27296060

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