RIMBP3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)5.11514640
2positive regulation of gamma-delta T cell activation (GO:0046645)4.57294794
3aggressive behavior (GO:0002118)4.55682503
4positive regulation of B cell differentiation (GO:0045579)4.39389373
5positive regulation of granulocyte differentiation (GO:0030854)4.36396192
6regulation of B cell receptor signaling pathway (GO:0050855)4.30822813
7B cell receptor signaling pathway (GO:0050853)4.28285234
8immunoglobulin mediated immune response (GO:0016064)4.13823663
9protoporphyrinogen IX metabolic process (GO:0046501)4.01867643
10dosage compensation (GO:0007549)3.96912619
11regulation of granulocyte differentiation (GO:0030852)3.89393199
12response to host immune response (GO:0052572)3.88669611
13response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88669611
14positive thymic T cell selection (GO:0045059)3.86625111
15negative regulation of granulocyte differentiation (GO:0030853)3.83636796
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83548622
17protoporphyrinogen IX biosynthetic process (GO:0006782)3.80458723
18regulation of MHC class I biosynthetic process (GO:0045343)3.52356720
19B cell mediated immunity (GO:0019724)3.49977907
20response to host (GO:0075136)3.49519880
21response to host defenses (GO:0052200)3.49519880
22response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.49519880
23regulation of B cell differentiation (GO:0045577)3.46990124
24regulation of interleukin-6 biosynthetic process (GO:0045408)3.38618441
25response to peptidoglycan (GO:0032494)3.34213705
26regulation of gamma-delta T cell differentiation (GO:0045586)3.32967419
27regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.30056098
28megakaryocyte development (GO:0035855)3.27647554
29regulation of B cell apoptotic process (GO:0002902)3.25899966
30histone H3-K36 demethylation (GO:0070544)3.25801126
31negative thymic T cell selection (GO:0045060)3.17062248
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17036801
33positive T cell selection (GO:0043368)3.10785344
34regulation of gamma-delta T cell activation (GO:0046643)3.05944941
35rRNA catabolic process (GO:0016075)3.03996031
36positive regulation of prostaglandin secretion (GO:0032308)3.03144928
37mature B cell differentiation involved in immune response (GO:0002313)3.02715714
38negative regulation of B cell apoptotic process (GO:0002903)3.01350699
39regulation of female receptivity (GO:0045924)2.98862524
40mature B cell differentiation (GO:0002335)2.94804403
41cellular response to exogenous dsRNA (GO:0071360)2.94657203
42negative T cell selection (GO:0043383)2.93981673
43regulation of RIG-I signaling pathway (GO:0039535)2.88481553
44positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.85470953
45regulation of mast cell degranulation (GO:0043304)2.85356076
46positive regulation of megakaryocyte differentiation (GO:0045654)2.85230465
47chaperone mediated protein folding requiring cofactor (GO:0051085)2.83966467
48positive regulation of antigen processing and presentation (GO:0002579)2.83083751
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.79670578
50cell wall macromolecule catabolic process (GO:0016998)2.75875865
51protein prenylation (GO:0018342)2.75131001
52prenylation (GO:0097354)2.75131001
53cellular extravasation (GO:0045123)2.73178746
54cellular response to ethanol (GO:0071361)2.71553833
55negative regulation of interleukin-17 production (GO:0032700)2.71133591
56nuclear pore complex assembly (GO:0051292)2.70314763
57regulation of histone H3-K9 methylation (GO:0051570)2.69743753
58hepatocyte apoptotic process (GO:0097284)2.69515547
59regulation of prostaglandin secretion (GO:0032306)2.68511971
60Peyers patch development (GO:0048541)2.68387690
61mucosal-associated lymphoid tissue development (GO:0048537)2.68387690
62regulation of antigen processing and presentation (GO:0002577)2.67301476
63phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.67291321
64positive regulation of CREB transcription factor activity (GO:0032793)2.67137986
65regulation of penile erection (GO:0060405)2.66542620
66regulation of mast cell activation involved in immune response (GO:0033006)2.64647825
67regulation of platelet aggregation (GO:0090330)2.59375280
68interkinetic nuclear migration (GO:0022027)2.59285419
69negative regulation of interleukin-12 production (GO:0032695)2.57163150
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57114362
71negative regulation of interleukin-6 production (GO:0032715)2.56031991
72positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.54541711
73negative regulation of erythrocyte differentiation (GO:0045647)2.54381608
74microtubule severing (GO:0051013)2.54333830
75regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53897214
76histone H3-K4 methylation (GO:0051568)2.53499267
77antigen processing and presentation of endogenous antigen (GO:0019883)2.51895170
78T cell selection (GO:0045058)2.49934029
79regulation of dendritic cell antigen processing and presentation (GO:0002604)2.49839933
80female mating behavior (GO:0060180)2.49076044
81hyperosmotic salinity response (GO:0042538)2.49034477
82thymic T cell selection (GO:0045061)2.48172880
83regulation of erythrocyte differentiation (GO:0045646)2.47438351
84regulation of necroptotic process (GO:0060544)2.45815157
85N-terminal protein amino acid acetylation (GO:0006474)2.43834487
86regulation of interleukin-17 production (GO:0032660)2.42464475
87response to muramyl dipeptide (GO:0032495)2.41541765
88cell wall macromolecule metabolic process (GO:0044036)2.39354674
89endothelium development (GO:0003158)2.38983560
90viral mRNA export from host cell nucleus (GO:0046784)2.38937415
91regulation of leukocyte degranulation (GO:0043300)2.38311474
92antigen receptor-mediated signaling pathway (GO:0050851)2.36980376
93poly(A)+ mRNA export from nucleus (GO:0016973)2.36648710
94peptidyl-lysine dimethylation (GO:0018027)2.35821660
95establishment of protein localization to Golgi (GO:0072600)2.34577163
96relaxation of smooth muscle (GO:0044557)2.34213157
97rRNA methylation (GO:0031167)2.34069894
98purine deoxyribonucleotide catabolic process (GO:0009155)2.34037582
99positive regulation of erythrocyte differentiation (GO:0045648)2.32486307
100regulation of histone H3-K27 methylation (GO:0061085)2.32155727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.04425793
2SCL_19346495_ChIP-Seq_HPC-7_Human3.93253506
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.74714655
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.56965586
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04279951
6E2F7_22180533_ChIP-Seq_HELA_Human2.72436826
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.70601869
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57894285
9VDR_21846776_ChIP-Seq_THP-1_Human2.55734280
10MYC_22102868_ChIP-Seq_BL_Human2.50349215
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.34251687
12MYB_26560356_Chip-Seq_TH2_Human2.33865771
13MYB_26560356_Chip-Seq_TH1_Human2.23888610
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.23356116
15CIITA_25753668_ChIP-Seq_RAJI_Human2.18452952
16SPI1_23547873_ChIP-Seq_NB4_Human2.16622111
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11158350
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10589880
19* SPI1_23127762_ChIP-Seq_K562_Human2.07909309
20VDR_24763502_ChIP-Seq_THP-1_Human2.07067631
21UTX_26944678_Chip-Seq_JUKART_Human2.01278589
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93926322
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93889899
24GATA1_19941826_ChIP-Seq_K562_Human1.91221738
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.90309658
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86478217
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85021922
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84991470
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84331057
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.84243082
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83348391
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82769383
33RUNX_20019798_ChIP-Seq_JUKART_Human1.81974626
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.81607092
35* MAF_26560356_Chip-Seq_TH1_Human1.81412232
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80899987
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80260655
38MAF_26560356_Chip-Seq_TH2_Human1.74805043
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.72263929
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69786474
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.67981806
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66177194
43TCF7_22412390_ChIP-Seq_EML_Mouse1.64134341
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64125926
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61785803
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60632629
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60435262
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60231518
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59130448
50GATA3_27048872_Chip-Seq_THYMUS_Human1.58622141
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56631877
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54692274
53KDM5A_27292631_Chip-Seq_BREAST_Human1.50409991
54GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48114525
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43145776
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38535470
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37493070
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.36958721
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36946005
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.34562965
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34255854
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29532601
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28830253
64KDM2B_26808549_Chip-Seq_DND41_Human1.28738221
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27200184
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24832707
67TFEB_21752829_ChIP-Seq_HELA_Human1.24774310
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22654254
69GATA3_26560356_Chip-Seq_TH2_Human1.21537260
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21132469
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20418725
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20378277
73ETS1_22383799_ChIP-Seq_G1ME_Mouse1.18246992
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.17845444
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16992704
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16588607
77RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15338869
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13983183
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12297763
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11184298
81VDR_23849224_ChIP-Seq_CD4+_Human1.10495513
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09009698
83FOXP3_21729870_ChIP-Seq_TREG_Human1.06044023
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05919948
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05846524
86GATA2_19941826_ChIP-Seq_K562_Human1.05777417
87PU_27001747_Chip-Seq_BMDM_Mouse1.05328911
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04809797
89BCL6_27268052_Chip-Seq_Bcells_Human1.03798141
90NCOR1_26117541_ChIP-Seq_K562_Human1.02434248
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.01851817
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01424485
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99904677
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97784599
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96956858
96* P300_27268052_Chip-Seq_Bcells_Human0.96883835
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96282742
98BCOR_27268052_Chip-Seq_Bcells_Human0.95316663
99P68_20966046_ChIP-Seq_HELA_Human0.92630002
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90642899

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.41297504
2MP0005397_hematopoietic_system_phenotyp3.14730379
3MP0001545_abnormal_hematopoietic_system3.14730379
4MP0002396_abnormal_hematopoietic_system3.02966794
5MP0004808_abnormal_hematopoietic_stem2.94276657
6MP0005410_abnormal_fertilization2.92657117
7MP0005464_abnormal_platelet_physiology2.75861868
8MP0009278_abnormal_bone_marrow2.69424322
9MP0005310_abnormal_salivary_gland2.65940222
10MP0003763_abnormal_thymus_physiology2.54611766
11MP0003303_peritoneal_inflammation2.42617317
12MP0002398_abnormal_bone_marrow2.08075834
13MP0003724_increased_susceptibility_to2.07644789
14MP0008058_abnormal_DNA_repair2.01904334
15MP0001800_abnormal_humoral_immune2.00851232
16MP0005387_immune_system_phenotype1.98304172
17MP0001790_abnormal_immune_system1.98304172
18MP0003436_decreased_susceptibility_to1.94637603
19MP0002419_abnormal_innate_immunity1.94471725
20MP0002138_abnormal_hepatobiliary_system1.92899764
21MP0004185_abnormal_adipocyte_glucose1.89732096
22MP0001986_abnormal_taste_sensitivity1.86367793
23MP0002452_abnormal_antigen_presenting1.83570266
24MP0002723_abnormal_immune_serum1.83422287
25MP0003191_abnormal_cellular_cholesterol1.81850289
26MP0005000_abnormal_immune_tolerance1.80043912
27MP0002420_abnormal_adaptive_immunity1.78843570
28MP0001819_abnormal_immune_cell1.75458704
29MP0003300_gastrointestinal_ulcer1.68328901
30MP0002148_abnormal_hypersensitivity_rea1.66789189
31MP0003656_abnormal_erythrocyte_physiolo1.65623768
32MP0000689_abnormal_spleen_morphology1.65356095
33MP0002722_abnormal_immune_system1.63235281
34MP0005451_abnormal_body_composition1.60844117
35MP0000716_abnormal_immune_system1.58141633
36MP0005025_abnormal_response_to1.56700413
37MP0009697_abnormal_copulation1.54047253
38MP0005645_abnormal_hypothalamus_physiol1.52992593
39MP0002405_respiratory_system_inflammati1.49757583
40MP0005671_abnormal_response_to1.47491141
41MP0002429_abnormal_blood_cell1.44400925
42MP0000685_abnormal_immune_system1.43874001
43MP0001851_eye_inflammation1.42991122
44MP0008057_abnormal_DNA_replication1.42642333
45MP0000703_abnormal_thymus_morphology1.38209914
46MP0005076_abnormal_cell_differentiation1.34540981
47MP0000569_abnormal_digit_pigmentation1.33502676
48MP0003828_pulmonary_edema1.33102824
49MP0000465_gastrointestinal_hemorrhage1.30102062
50MP0009764_decreased_sensitivity_to1.27981597
51MP0003111_abnormal_nucleus_morphology1.26263894
52MP0002019_abnormal_tumor_incidence1.25434645
53MP0010352_gastrointestinal_tract_polyps1.24029803
54MP0002132_abnormal_respiratory_system1.23566392
55MP0010094_abnormal_chromosome_stability1.21286802
56MP0003077_abnormal_cell_cycle1.19365726
57MP0003866_abnormal_defecation1.14213904
58MP0000015_abnormal_ear_pigmentation1.12663722
59MP0003172_abnormal_lysosome_physiology1.11461909
60MP0008469_abnormal_protein_level1.10325611
61MP0010307_abnormal_tumor_latency1.10127781
62MP0006082_CNS_inflammation1.06759792
63MP0010386_abnormal_urinary_bladder0.99004328
64MP0008007_abnormal_cellular_replicative0.98230079
65MP0005075_abnormal_melanosome_morpholog0.94185347
66MP0003221_abnormal_cardiomyocyte_apopto0.94066395
67MP0001929_abnormal_gametogenesis0.93216276
68MP0005220_abnormal_exocrine_pancreas0.91418479
69MP0010155_abnormal_intestine_physiology0.91353553
70MP0009765_abnormal_xenobiotic_induced0.87851131
71MP0001845_abnormal_inflammatory_respons0.85053832
72MP0000313_abnormal_cell_death0.84216165
73MP0002998_abnormal_bone_remodeling0.83718124
74MP0005666_abnormal_adipose_tissue0.82708126
75MP0001764_abnormal_homeostasis0.81233648
76MP0002332_abnormal_exercise_endurance0.80130470
77MP0002166_altered_tumor_susceptibility0.79424307
78MP0003315_abnormal_perineum_morphology0.76361918
79MP0000858_altered_metastatic_potential0.75589849
80MP0006035_abnormal_mitochondrial_morpho0.75280823
81MP0006054_spinal_hemorrhage0.74367179
82MP0009785_altered_susceptibility_to0.74314724
83MP0003786_premature_aging0.74216678
84MP0001533_abnormal_skeleton_physiology0.72552504
85MP0005367_renal/urinary_system_phenotyp0.71330128
86MP0000516_abnormal_urinary_system0.71330128
87MP0000350_abnormal_cell_proliferation0.70945206
88MP0003091_abnormal_cell_migration0.70376180
89MP0001664_abnormal_digestion0.70294169
90MP0000681_abnormal_thyroid_gland0.70283521
91MP0004381_abnormal_hair_follicle0.70163972
92MP0009115_abnormal_fat_cell0.70037921
93MP0005083_abnormal_biliary_tract0.69267446
94MP0004947_skin_inflammation0.69203593
95MP0000013_abnormal_adipose_tissue0.69065899
96MP0003693_abnormal_embryo_hatching0.68942010
97MP0000358_abnormal_cell_content/0.68681570
98MP0003698_abnormal_male_reproductive0.68225117
99MP0008873_increased_physiological_sensi0.65143185
100MP0009763_increased_sensitivity_to0.63777662

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)5.41403768
2Colitis (HP:0002583)4.67038869
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.18057131
4Autoimmune thrombocytopenia (HP:0001973)3.99129047
5Urethral obstruction (HP:0000796)3.92771490
6Fatigue (HP:0012378)3.90593251
7Chronic mucocutaneous candidiasis (HP:0002728)3.89164790
8Recurrent cutaneous fungal infections (HP:0011370)3.89164790
9Agammaglobulinemia (HP:0004432)3.80316830
10Recurrent viral infections (HP:0004429)3.76955290
11Recurrent fungal infections (HP:0002841)3.74618803
12Viral hepatitis (HP:0006562)3.54073445
13Abnormality of the columella (HP:0009929)3.50663851
14Recurrent bacterial skin infections (HP:0005406)3.41474194
15Inflammation of the large intestine (HP:0002037)3.34985344
16Recurrent skin infections (HP:0001581)3.24289349
17Recurrent abscess formation (HP:0002722)3.23364155
18Cellulitis (HP:0100658)3.14727533
19Gastrointestinal inflammation (HP:0004386)3.14006225
20Progressive external ophthalmoplegia (HP:0000590)3.07992070
21Abnormality of the fingertips (HP:0001211)2.99018290
22Syringomyelia (HP:0003396)2.94868544
23Spinal cord lesions (HP:0100561)2.94868544
24Acute lymphatic leukemia (HP:0006721)2.85439943
25Abnormality of T cell physiology (HP:0011840)2.80084492
26Sensory axonal neuropathy (HP:0003390)2.80026292
27Encephalitis (HP:0002383)2.62609846
28Abnormality of T cells (HP:0002843)2.61371003
29Meningitis (HP:0001287)2.59572049
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59343594
31Obstructive lung disease (HP:0006536)2.59108881
32Chronic obstructive pulmonary disease (HP:0006510)2.59108881
33Prominent nose (HP:0000448)2.57356017
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.56663911
35Mediastinal lymphadenopathy (HP:0100721)2.56359192
36Myositis (HP:0100614)2.55425870
37Ragged-red muscle fibers (HP:0003200)2.52178676
38Prolonged bleeding time (HP:0003010)2.51836266
39Increased cerebral lipofuscin (HP:0011813)2.49668430
40Stomatitis (HP:0010280)2.43365648
41Autoimmune hemolytic anemia (HP:0001890)2.38793019
42Cerebellar dysplasia (HP:0007033)2.38681826
43Cutaneous melanoma (HP:0012056)2.37844773
44Abnormality of B cell number (HP:0010975)2.37101706
45Increased IgM level (HP:0003496)2.35513993
46Thrombocytosis (HP:0001894)2.32292641
47Genetic anticipation (HP:0003743)2.30082690
48Spinal muscular atrophy (HP:0007269)2.28285771
49Arterial thrombosis (HP:0004420)2.20885088
50Epistaxis (HP:0000421)2.20335178
51Aplasia/Hypoplasia of the thymus (HP:0010515)2.18252472
52Attenuation of retinal blood vessels (HP:0007843)2.17032696
53Granulocytopenia (HP:0001913)2.16795750
54Stomach cancer (HP:0012126)2.16473828
55Elevated erythrocyte sedimentation rate (HP:0003565)2.08993808
56Acute myeloid leukemia (HP:0004808)2.08387782
57Gingival bleeding (HP:0000225)2.07680534
58Clumsiness (HP:0002312)2.06134005
59Hepatitis (HP:0012115)2.03917932
60Disinhibition (HP:0000734)2.03261204
61Chest pain (HP:0100749)2.01635771
62Eczematoid dermatitis (HP:0000976)2.01468804
63B lymphocytopenia (HP:0010976)2.00896275
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00763879
65Ureteral obstruction (HP:0006000)2.00355319
66Hypoplasia of the thymus (HP:0000778)1.97095822
67Myelodysplasia (HP:0002863)1.96577670
68Ureteral stenosis (HP:0000071)1.95405496
69Abnormality of T cell number (HP:0011839)1.93466559
70Clubbing of toes (HP:0100760)1.93017534
71Acute hepatic failure (HP:0006554)1.92245087
72Basal cell carcinoma (HP:0002671)1.88920583
73Increased IgE level (HP:0003212)1.88352578
74Postural instability (HP:0002172)1.87799152
75Orchitis (HP:0100796)1.86332527
76Chronic hepatic failure (HP:0100626)1.85038063
77Pustule (HP:0200039)1.84664870
78Cutis marmorata (HP:0000965)1.82819991
79Abnormality of the prostate (HP:0008775)1.81852096
80Poikiloderma (HP:0001029)1.80469483
81Progressive muscle weakness (HP:0003323)1.80431406
82Eosinophilia (HP:0001880)1.80135087
83Abnormality of transition element cation homeostasis (HP:0011030)1.80116883
84Abnormality of iron homeostasis (HP:0011031)1.79687752
85Widely spaced teeth (HP:0000687)1.78460695
86Thyroiditis (HP:0100646)1.77958927
87Abnormality of liposaccharide metabolism (HP:0010968)1.74942048
88Abnormality of glycosphingolipid metabolism (HP:0004343)1.74942048
89Abnormality of glycolipid metabolism (HP:0010969)1.74942048
90Abnormality of the thymus (HP:0000777)1.73408348
91Retrobulbar optic neuritis (HP:0100654)1.72545660
92Optic neuritis (HP:0100653)1.72545660
93Portal hypertension (HP:0001409)1.71636529
94T lymphocytopenia (HP:0005403)1.71208306
95Poor speech (HP:0002465)1.70221243
96Spontaneous hematomas (HP:0007420)1.69886770
97Urticaria (HP:0001025)1.66877514
98Glucose intolerance (HP:0000833)1.66785958
99Anorexia (HP:0002039)1.66345670
100Abnormality of the heme biosynthetic pathway (HP:0010472)1.65979511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.08972709
2ZAK3.57840535
3CDK122.62334742
4TRIB32.59950581
5TEC2.55662620
6TLK12.45844111
7PBK2.37558663
8TNK22.28164413
9BTK2.20796078
10MAP4K12.01140149
11PKN21.82914396
12ITK1.80061532
13CAMK1D1.74393384
14TXK1.73885328
15SYK1.70508508
16PINK11.66882320
17SCYL21.66695069
18TESK21.61600598
19EIF2AK31.60854106
20BLK1.58859188
21RPS6KA51.49631725
22CDK191.47910033
23FES1.46400734
24RIPK41.41843699
25MAP3K21.38816826
26HCK1.38562433
27GRK61.34710848
28STK41.34662665
29TBK11.33482499
30TYK21.29335412
31ERN11.28093259
32PLK41.27935512
33BRD41.27556416
34FLT31.26780042
35CSF1R1.26331694
36PIK3CG1.23457916
37MAP3K111.19740446
38CDC42BPA1.17408308
39CAMKK21.14518998
40NME21.13033109
41CAMK1G1.09032401
42CCNB11.07183773
43MST41.05360122
44PRKD21.05088142
45VRK11.02925277
46DYRK31.02812607
47KIT1.01831675
48JAK31.01146180
49MARK30.95700960
50MAP3K140.94833489
51ZAP700.92630769
52RET0.87616657
53MAPK110.87445536
54LCK0.86843338
55MAP3K10.86627664
56IKBKE0.86483519
57KSR20.84649897
58NEK20.84215918
59FRK0.82123278
60CDK30.77990555
61ATR0.77703890
62CDK60.77572108
63IRAK20.75411081
64TAOK10.73449563
65MAP2K70.73244967
66MAP2K30.72911582
67CHEK20.72043847
68LYN0.70809651
69IKBKB0.67652186
70RPS6KB20.66440578
71EEF2K0.65953245
72STK380.64976143
73MARK20.63868239
74JAK20.61647260
75CSK0.61162752
76PDK10.57227368
77JAK10.56916243
78FGFR30.54014532
79RAF10.53892049
80MAP2K20.53818187
81AURKB0.53477820
82SIK20.52928133
83CDK40.52380487
84MAP3K30.51129272
85MAPK70.51010806
86MTOR0.50776745
87WNK10.50494070
88IRAK10.49851733
89MAP3K80.49528167
90CAMKK10.49090304
91AURKA0.48762306
92CDK70.48260339
93CDC70.48194025
94RPS6KA10.46741954
95RPS6KA60.46127560
96ATM0.45720959
97BMPR20.45576305
98CHEK10.45402668
99MAP3K130.43745361
100TRPM70.42958522

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.89368784
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.57736586
3B cell receptor signaling pathway_Homo sapiens_hsa046622.46667705
4Alcoholism_Homo sapiens_hsa050342.16724831
5Allograft rejection_Homo sapiens_hsa053302.08684553
6Primary immunodeficiency_Homo sapiens_hsa053402.03286708
7Leishmaniasis_Homo sapiens_hsa051401.98982044
8Graft-versus-host disease_Homo sapiens_hsa053321.98253035
9Asthma_Homo sapiens_hsa053101.91452683
10Autoimmune thyroid disease_Homo sapiens_hsa053201.89750882
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.75526447
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75239858
13Herpes simplex infection_Homo sapiens_hsa051681.67265709
14Acute myeloid leukemia_Homo sapiens_hsa052211.66385422
15Platelet activation_Homo sapiens_hsa046111.66337632
16Other glycan degradation_Homo sapiens_hsa005111.64116170
17Osteoclast differentiation_Homo sapiens_hsa043801.64068114
18Antigen processing and presentation_Homo sapiens_hsa046121.61722224
19Tuberculosis_Homo sapiens_hsa051521.57748986
20Viral carcinogenesis_Homo sapiens_hsa052031.56146273
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.52470200
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46154309
23Non-small cell lung cancer_Homo sapiens_hsa052231.45698899
24Staphylococcus aureus infection_Homo sapiens_hsa051501.40192464
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37677220
26Inositol phosphate metabolism_Homo sapiens_hsa005621.37461703
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35778454
28Toxoplasmosis_Homo sapiens_hsa051451.34011379
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.32577070
30T cell receptor signaling pathway_Homo sapiens_hsa046601.31077804
31Influenza A_Homo sapiens_hsa051641.29111625
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26093936
33Pancreatic cancer_Homo sapiens_hsa052121.26091398
34Type I diabetes mellitus_Homo sapiens_hsa049401.22193830
35Measles_Homo sapiens_hsa051621.21368920
36Fanconi anemia pathway_Homo sapiens_hsa034601.14177580
37Viral myocarditis_Homo sapiens_hsa054161.13396492
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09048094
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08488318
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07681397
41Base excision repair_Homo sapiens_hsa034101.03450915
42Homologous recombination_Homo sapiens_hsa034401.02216048
43Non-homologous end-joining_Homo sapiens_hsa034501.01234935
44Prolactin signaling pathway_Homo sapiens_hsa049170.98434177
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97976088
46Hepatitis B_Homo sapiens_hsa051610.97834373
47Chronic myeloid leukemia_Homo sapiens_hsa052200.97013225
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96366848
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96152486
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.94815898
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94731213
52mTOR signaling pathway_Homo sapiens_hsa041500.93549306
53VEGF signaling pathway_Homo sapiens_hsa043700.88704736
54Lysine degradation_Homo sapiens_hsa003100.88429734
55African trypanosomiasis_Homo sapiens_hsa051430.87546273
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85738034
57Apoptosis_Homo sapiens_hsa042100.84463199
58Lysosome_Homo sapiens_hsa041420.77772084
59Selenocompound metabolism_Homo sapiens_hsa004500.77542294
60Renin secretion_Homo sapiens_hsa049240.76672481
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74605648
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74409251
63Hematopoietic cell lineage_Homo sapiens_hsa046400.73445954
64TNF signaling pathway_Homo sapiens_hsa046680.71841937
65Olfactory transduction_Homo sapiens_hsa047400.71310927
66Choline metabolism in cancer_Homo sapiens_hsa052310.71155813
67Epstein-Barr virus infection_Homo sapiens_hsa051690.69160636
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.65951412
69Endometrial cancer_Homo sapiens_hsa052130.64050819
70HTLV-I infection_Homo sapiens_hsa051660.63711758
71Glioma_Homo sapiens_hsa052140.63573711
72Hepatitis C_Homo sapiens_hsa051600.63385236
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.62557379
74DNA replication_Homo sapiens_hsa030300.61905926
75Malaria_Homo sapiens_hsa051440.61871709
76ErbB signaling pathway_Homo sapiens_hsa040120.59550594
77Chemokine signaling pathway_Homo sapiens_hsa040620.58294804
78Gap junction_Homo sapiens_hsa045400.56923280
79Shigellosis_Homo sapiens_hsa051310.56132392
80Colorectal cancer_Homo sapiens_hsa052100.54673927
81Rheumatoid arthritis_Homo sapiens_hsa053230.50226651
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.48701940
83Type II diabetes mellitus_Homo sapiens_hsa049300.48377595
84Long-term depression_Homo sapiens_hsa047300.46636520
85Estrogen signaling pathway_Homo sapiens_hsa049150.46426582
86Regulation of autophagy_Homo sapiens_hsa041400.45649884
87Phagosome_Homo sapiens_hsa041450.45074483
88p53 signaling pathway_Homo sapiens_hsa041150.44230301
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43655187
90Insulin resistance_Homo sapiens_hsa049310.42019599
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41712921
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41598349
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41583821
94RNA transport_Homo sapiens_hsa030130.41169097
95Dorso-ventral axis formation_Homo sapiens_hsa043200.40836347
96MAPK signaling pathway_Homo sapiens_hsa040100.40618179
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40049504
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39723192
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38661367
100Pertussis_Homo sapiens_hsa051330.38549325

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