RIMBP3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)8.92970763
2pore complex assembly (GO:0046931)7.61413541
3negative regulation of DNA repair (GO:0045738)5.50790409
4DNA unwinding involved in DNA replication (GO:0006268)4.54342746
5cellular response to ethanol (GO:0071361)4.42605570
6innate immune response in mucosa (GO:0002227)4.28465275
7embryonic process involved in female pregnancy (GO:0060136)4.01609056
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.94609342
9phospholipid translocation (GO:0045332)3.93566829
10lipid translocation (GO:0034204)3.93566829
11DNA duplex unwinding (GO:0032508)3.90569807
12positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.88495622
13mitotic sister chromatid cohesion (GO:0007064)3.82021111
14labyrinthine layer development (GO:0060711)3.78818310
15cytoplasmic mRNA processing body assembly (GO:0033962)3.78132700
16DNA geometric change (GO:0032392)3.76773455
17peptidyl-lysine dimethylation (GO:0018027)3.76370268
18regulation of transforming growth factor beta2 production (GO:0032909)3.72559520
19dosage compensation (GO:0007549)3.71003929
20mature B cell differentiation (GO:0002335)3.62962609
21regulation of centriole replication (GO:0046599)3.52771588
22regulation of sister chromatid cohesion (GO:0007063)3.52013977
23pre-miRNA processing (GO:0031054)3.47891267
24mucosal immune response (GO:0002385)3.44664950
25monoubiquitinated protein deubiquitination (GO:0035520)3.43556421
26double-strand break repair via nonhomologous end joining (GO:0006303)3.42002113
27non-recombinational repair (GO:0000726)3.42002113
28histone H3-K36 demethylation (GO:0070544)3.39793084
29regulation of histone H3-K9 methylation (GO:0051570)3.37593668
30mature B cell differentiation involved in immune response (GO:0002313)3.35577917
31response to UV-C (GO:0010225)3.33100709
32histone-serine phosphorylation (GO:0035404)3.30521859
33regulation of centrosome duplication (GO:0010824)3.26160024
34organ or tissue specific immune response (GO:0002251)3.24311444
35positive regulation of DNA-templated transcription, initiation (GO:2000144)3.23802635
36positive regulation of developmental pigmentation (GO:0048087)3.20093074
37antibacterial humoral response (GO:0019731)3.19167079
38protein K48-linked deubiquitination (GO:0071108)3.10902202
39regulation of protein polyubiquitination (GO:1902914)3.06657414
40positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.03601443
41pinocytosis (GO:0006907)3.02939642
42embryonic camera-type eye morphogenesis (GO:0048596)3.02208904
43regulation of DNA damage checkpoint (GO:2000001)2.97739149
44regulation of pigment cell differentiation (GO:0050932)2.97595135
45regulation of centrosome cycle (GO:0046605)2.96111446
46regulation of hippo signaling (GO:0035330)2.93610908
47definitive hemopoiesis (GO:0060216)2.91543807
48mitotic chromosome condensation (GO:0007076)2.88199403
49establishment of nucleus localization (GO:0040023)2.87022446
50protein destabilization (GO:0031648)2.86377047
51protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.85867148
52somatic recombination of immunoglobulin gene segments (GO:0016447)2.85338516
53antimicrobial humoral response (GO:0019730)2.82913350
54histone H3-K9 demethylation (GO:0033169)2.80923658
55dorsal/ventral axis specification (GO:0009950)2.80467718
56regulation of RNA export from nucleus (GO:0046831)2.78065510
57histone phosphorylation (GO:0016572)2.77112156
58nucleus organization (GO:0006997)2.76667253
59positive regulation of cell cycle checkpoint (GO:1901978)2.76603977
60interkinetic nuclear migration (GO:0022027)2.75275346
61cellular protein complex localization (GO:0034629)2.75028125
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73344731
63replicative senescence (GO:0090399)2.71589787
64histone lysine demethylation (GO:0070076)2.68897299
65regulation of skeletal muscle cell differentiation (GO:2001014)2.66854988
66regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.66399605
67B cell receptor signaling pathway (GO:0050853)2.63895474
68DNA conformation change (GO:0071103)2.63729830
69DNA replication initiation (GO:0006270)2.63113936
70DNA synthesis involved in DNA repair (GO:0000731)2.60523016
71nucleus localization (GO:0051647)2.60065800
72protein localization to endosome (GO:0036010)2.59631506
73regulation of establishment of cell polarity (GO:2000114)2.58125790
74sister chromatid segregation (GO:0000819)2.57854206
75V(D)J recombination (GO:0033151)2.56567269
76centrosome duplication (GO:0051298)2.55869318
77fibroblast migration (GO:0010761)2.54420048
78chromatin assembly (GO:0031497)2.54287988
79snRNA transcription (GO:0009301)2.53588147
80histone mRNA catabolic process (GO:0071044)2.53536221
81histone demethylation (GO:0016577)2.52619255
82mitotic nuclear envelope disassembly (GO:0007077)2.52331206
83somatic diversification of immunoglobulins (GO:0016445)2.51771124
84nucleosome assembly (GO:0006334)2.51345286
85B cell activation involved in immune response (GO:0002312)2.51159205
86embryonic eye morphogenesis (GO:0048048)2.49339959
87somitogenesis (GO:0001756)2.48231132
88cellular response to gamma radiation (GO:0071480)2.46356506
89chondrocyte development (GO:0002063)2.45279258
90membrane disassembly (GO:0030397)2.44697325
91nuclear envelope disassembly (GO:0051081)2.44697325
92positive regulation of catenin import into nucleus (GO:0035413)2.44075800
93protein localization to chromosome, centromeric region (GO:0071459)2.41937619
94regulation of membrane lipid distribution (GO:0097035)2.41127598
95oocyte development (GO:0048599)2.41013363
96necroptotic process (GO:0070266)2.39510906
97regulation of nucleobase-containing compound transport (GO:0032239)2.38029159
98retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37896325
99positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.37681111
100nuclear pore complex assembly (GO:0051292)10.1230930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.59580128
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.53295781
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51056182
4GATA1_22025678_ChIP-Seq_K562_Human3.33410967
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.25665350
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68837004
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.43937926
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.37023829
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.32291408
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27223058
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03001067
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.4501514
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89706163
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86044468
15AR_21909140_ChIP-Seq_LNCAP_Human1.85564193
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.85472471
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.85232691
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77220976
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49268268
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48653762
21* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45820085
22* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45820085
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43733565
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42150294
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37879746
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37617797
27TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33538226
28TP53_16413492_ChIP-PET_HCT116_Human1.30316997
29AHR_22903824_ChIP-Seq_MCF-7_Human1.28579992
30FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27934148
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25324726
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24305738
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.20467208
34FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18198760
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15856566
36SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14898837
37BRD4_25478319_ChIP-Seq_HGPS_Human1.14416428
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13013572
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07305785
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06313278
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06313278
42FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04939672
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04226971
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.04135936
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04074921
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.03818228
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03268377
48ELK1_19687146_ChIP-ChIP_HELA_Human0.99982750
49EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99499807
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98286111
51ARNT_22903824_ChIP-Seq_MCF-7_Human0.96050898
52EWS_26573619_Chip-Seq_HEK293_Human0.95598007
53PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94174989
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93949780
55BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92974853
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92890790
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92739009
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92354068
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90900361
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90563457
61FUS_26573619_Chip-Seq_HEK293_Human0.89974732
62SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89475611
63POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88002149
64TP63_17297297_ChIP-ChIP_HaCaT_Human0.87741410
65ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87456653
66SALL4_22934838_ChIP-ChIP_CD34+_Human0.87402811
67SCL_19346495_ChIP-Seq_HPC-7_Human0.86954158
68ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86479061
69IGF1R_20145208_ChIP-Seq_DFB_Human0.84789410
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84772765
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84039114
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83511478
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83476126
74TAF15_26573619_Chip-Seq_HEK293_Human0.83394429
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82798746
76NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82653265
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81244645
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81149322
79STAT3_23295773_ChIP-Seq_U87_Human0.81131739
80ER_23166858_ChIP-Seq_MCF-7_Human0.81006322
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80815939
82PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80100273
83AR_21572438_ChIP-Seq_LNCaP_Human0.79598438
84CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78770327
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78062426
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.77723324
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.76907783
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75814669
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75676265
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75575117
91EP300_21415370_ChIP-Seq_HL-1_Mouse0.74462747
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.73546796
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72992760
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72806371
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72702727
96TP53_18474530_ChIP-ChIP_U2OS_Human0.71338529
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.70500149
98NELFA_20434984_ChIP-Seq_ESCs_Mouse0.70391069
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.70309911
100SMAD4_21799915_ChIP-Seq_A2780_Human0.69923787

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.81887002
2MP0002009_preneoplasia5.28936399
3MP0010352_gastrointestinal_tract_polyps5.04992135
4MP0010234_abnormal_vibrissa_follicle3.55674542
5MP0000569_abnormal_digit_pigmentation3.32045947
6MP0002166_altered_tumor_susceptibility2.59643289
7MP0003705_abnormal_hypodermis_morpholog2.50988457
8MP0010094_abnormal_chromosome_stability2.39364618
9MP0001661_extended_life_span2.19218295
10MP0010307_abnormal_tumor_latency2.18440130
11MP0002877_abnormal_melanocyte_morpholog2.13912481
12MP0010678_abnormal_skin_adnexa2.13844283
13MP0004808_abnormal_hematopoietic_stem2.09838020
14MP0003077_abnormal_cell_cycle2.09520951
15MP0005076_abnormal_cell_differentiation2.02910276
16MP0002006_tumorigenesis1.93738065
17MP0003868_abnormal_feces_composition1.91308655
18MP0003091_abnormal_cell_migration1.89698027
19MP0000537_abnormal_urethra_morphology1.81176699
20MP0000383_abnormal_hair_follicle1.79856152
21MP0004185_abnormal_adipocyte_glucose1.78241020
22MP0003941_abnormal_skin_development1.76111436
23MP0003300_gastrointestinal_ulcer1.65820875
24MP0009697_abnormal_copulation1.64295075
25MP0008007_abnormal_cellular_replicative1.60590592
26MP0005409_darkened_coat_color1.57562847
27MP0001915_intracranial_hemorrhage1.55009159
28MP0002396_abnormal_hematopoietic_system1.52345416
29MP0003111_abnormal_nucleus_morphology1.51727216
30MP0008438_abnormal_cutaneous_collagen1.49610349
31MP0006054_spinal_hemorrhage1.48822122
32MP0004957_abnormal_blastocyst_morpholog1.48669035
33MP0003763_abnormal_thymus_physiology1.44574323
34MP0000465_gastrointestinal_hemorrhage1.41263965
35MP0003221_abnormal_cardiomyocyte_apopto1.32856213
36MP0003453_abnormal_keratinocyte_physiol1.29647330
37MP0005248_abnormal_Harderian_gland1.29204464
38MP0003890_abnormal_embryonic-extraembry1.26621043
39MP0000733_abnormal_muscle_development1.23757511
40MP0000428_abnormal_craniofacial_morphol1.22674579
41MP0002086_abnormal_extraembryonic_tissu1.19852310
42MP0003566_abnormal_cell_adhesion1.17006106
43MP0003950_abnormal_plasma_membrane1.16055794
44MP0001879_abnormal_lymphatic_vessel1.14959877
45MP0003984_embryonic_growth_retardation1.14616001
46MP0000350_abnormal_cell_proliferation1.11283909
47MP0002088_abnormal_embryonic_growth/wei1.11184557
48MP0002092_abnormal_eye_morphology1.07970146
49MP0003786_premature_aging1.07006618
50MP0005275_abnormal_skin_tensile1.06509591
51MP0000427_abnormal_hair_cycle1.05626037
52MP0005380_embryogenesis_phenotype1.04383972
53MP0001672_abnormal_embryogenesis/_devel1.04383972
54MP0002697_abnormal_eye_size1.01893735
55MP0000015_abnormal_ear_pigmentation1.01373594
56MP0008058_abnormal_DNA_repair1.00590120
57MP0003828_pulmonary_edema0.99965915
58MP0005647_abnormal_sex_gland0.99706926
59MP0000013_abnormal_adipose_tissue0.93728325
60MP0000377_abnormal_hair_follicle0.90308504
61MP0004134_abnormal_chest_morphology0.90121133
62MP0002084_abnormal_developmental_patter0.89235308
63MP0005621_abnormal_cell_physiology0.87294476
64MP0004084_abnormal_cardiac_muscle0.85234511
65MP0002332_abnormal_exercise_endurance0.83395697
66MP0001873_stomach_inflammation0.82590174
67MP0003191_abnormal_cellular_cholesterol0.82534810
68MP0002060_abnormal_skin_morphology0.80603065
69MP0003866_abnormal_defecation0.80305341
70MP0000490_abnormal_crypts_of0.77354375
71MP0004036_abnormal_muscle_relaxation0.77179360
72MP0005220_abnormal_exocrine_pancreas0.76793445
73MP0000462_abnormal_digestive_system0.73381480
74MP0001697_abnormal_embryo_size0.72614619
75MP0000627_abnormal_mammary_gland0.71665309
76MP0003937_abnormal_limbs/digits/tail_de0.71662407
77MP0002019_abnormal_tumor_incidence0.71002073
78MP0003632_abnormal_nervous_system0.70845508
79MP0003935_abnormal_craniofacial_develop0.70008546
80MP0005310_abnormal_salivary_gland0.69772605
81MP0004233_abnormal_muscle_weight0.69609987
82MP0005384_cellular_phenotype0.69084849
83MP0004272_abnormal_basement_membrane0.68864910
84MP0000371_diluted_coat_color0.68174154
85MP0005187_abnormal_penis_morphology0.67861345
86MP0001835_abnormal_antigen_presentation0.67253997
87MP0001849_ear_inflammation0.67096195
88MP0002080_prenatal_lethality0.66501601
89MP0001730_embryonic_growth_arrest0.66133020
90MP0003385_abnormal_body_wall0.65864116
91MP0004130_abnormal_muscle_cell0.65791372
92MP0000358_abnormal_cell_content/0.65338125
93MP0005023_abnormal_wound_healing0.65019427
94MP0002896_abnormal_bone_mineralization0.64884842
95MP0004264_abnormal_extraembryonic_tissu0.64170632
96MP0008932_abnormal_embryonic_tissue0.63998281
97MP0004197_abnormal_fetal_growth/weight/0.63804116
98MP0001191_abnormal_skin_condition0.63578915
99MP0003115_abnormal_respiratory_system0.63103054
100MP0001177_atelectasis0.61705603

Predicted human phenotypes

RankGene SetZ-score
1Colitis (HP:0002583)4.06161141
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54238949
3IgA deficiency (HP:0002720)3.37613039
4Papillary thyroid carcinoma (HP:0002895)3.36210929
5Osteolytic defects of the phalanges of the hand (HP:0009771)3.34813820
6Osteolytic defects of the hand bones (HP:0009699)3.34813820
7Interstitial pulmonary disease (HP:0006530)3.30071271
8IgM deficiency (HP:0002850)3.25438533
9Chromsome breakage (HP:0040012)3.20166968
10Subacute progressive viral hepatitis (HP:0006572)3.19218437
11Dysmetric saccades (HP:0000641)3.04801047
12Thyroiditis (HP:0100646)2.97522870
13Thyroid carcinoma (HP:0002890)2.82216844
14Short nail (HP:0001799)2.80362301
15Abnormality of chromosome stability (HP:0003220)2.70213022
16Entropion (HP:0000621)2.59671771
17Ankyloglossia (HP:0010296)2.59474974
18Heterotopia (HP:0002282)2.58812913
19Medulloblastoma (HP:0002885)2.57407474
20Syringomyelia (HP:0003396)2.56468494
21Spinal cord lesions (HP:0100561)2.56468494
22Absent frontal sinuses (HP:0002688)2.54434864
23Short chin (HP:0000331)2.53971439
24Sandal gap (HP:0001852)2.51658277
25Abnormality of the astrocytes (HP:0100707)2.47902294
26Astrocytoma (HP:0009592)2.47902294
27Acute myeloid leukemia (HP:0004808)2.46851397
28Deep philtrum (HP:0002002)2.45776307
29Missing ribs (HP:0000921)2.44266427
30Tetraparesis (HP:0002273)2.43803230
31Asymmetry of the thorax (HP:0001555)2.37337983
32Conjunctival telangiectasia (HP:0000524)2.34835985
33Relative macrocephaly (HP:0004482)2.34773663
34Ependymoma (HP:0002888)2.34162179
35Viral hepatitis (HP:0006562)2.32391790
3611 pairs of ribs (HP:0000878)2.30371340
37Neoplasm of the peripheral nervous system (HP:0100007)2.29006401
38Abnormality of oral frenula (HP:0000190)2.28448974
39T lymphocytopenia (HP:0005403)2.27128561
40Renovascular hypertension (HP:0100817)2.26672807
41Submucous cleft hard palate (HP:0000176)2.24356820
42Large earlobe (HP:0009748)2.23745190
43Neonatal hypoglycemia (HP:0001998)2.23570354
44Pheochromocytoma (HP:0002666)2.21417791
45Germ cell neoplasia (HP:0100728)2.21046581
46Abnormal glucose tolerance (HP:0001952)2.19844402
47Abnormality of the vasculature of the conjunctiva (HP:0008054)2.17635260
48Glioma (HP:0009733)2.17519826
49Glucose intolerance (HP:0000833)2.15054811
50Rhabdomyosarcoma (HP:0002859)2.14774383
51Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.14026108
52Overgrowth (HP:0001548)2.11580972
53Flat acetabular roof (HP:0003180)2.09486383
54Abnormal foot bone ossification (HP:0010675)2.05701000
55Progressive external ophthalmoplegia (HP:0000590)2.03546700
56Inflammation of the large intestine (HP:0002037)2.02325998
57Gastrointestinal carcinoma (HP:0002672)1.98696100
58Malignant gastrointestinal tract tumors (HP:0006749)1.98696100
59Curly hair (HP:0002212)1.98652691
60Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.96925510
61Abnormality of the distal phalanx of the thumb (HP:0009617)1.96655017
62Cafe-au-lait spot (HP:0000957)1.94676013
63Insidious onset (HP:0003587)1.94404983
64Termporal pattern (HP:0011008)1.94404983
65Scanning speech (HP:0002168)1.93893618
66Nephroblastoma (Wilms tumor) (HP:0002667)1.93401406
67Periodontitis (HP:0000704)1.93272623
68Gingivitis (HP:0000230)1.92653468
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88887341
70Short 4th metacarpal (HP:0010044)1.88887341
71Embryonal renal neoplasm (HP:0011794)1.88680002
72Recurrent viral infections (HP:0004429)1.88561189
73Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87575441
74Cellulitis (HP:0100658)1.86594550
75Cubitus valgus (HP:0002967)1.86103603
76Natal tooth (HP:0000695)1.83642024
77Acute lymphatic leukemia (HP:0006721)1.83069843
78Dislocated radial head (HP:0003083)1.82310866
79Menstrual irregularities (HP:0000858)1.82253913
80Uterine leiomyosarcoma (HP:0002891)1.81917122
81Leiomyosarcoma (HP:0100243)1.81917122
82Bladder neoplasm (HP:0009725)1.81464826
83Bladder carcinoma (HP:0002862)1.81464826
84Prominent nose (HP:0000448)1.81337767
85Skull defect (HP:0001362)1.80943956
86Arterial tortuosity (HP:0005116)1.79705896
87Broad ribs (HP:0000885)1.78577870
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78192961
89Spastic diplegia (HP:0001264)1.77975071
90Thoracolumbar scoliosis (HP:0002944)1.76881975
91Neoplasm of striated muscle (HP:0009728)1.76094321
92Subcapsular cataract (HP:0000523)1.75790314
93Gastrointestinal inflammation (HP:0004386)1.75776455
94Hypopigmentation of the fundus (HP:0007894)1.74543855
95Transitional cell carcinoma of the bladder (HP:0006740)1.73241471
96Micronodular cirrhosis (HP:0001413)1.70540744
97Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.69828709
98Hyperacusis (HP:0010780)1.69595958
99Cystic hygroma (HP:0000476)1.67548154
100Abnormality of the epiphyses of the hand (HP:0005924)1.66603870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL24.28971910
2ZAK3.34577464
3EEF2K3.32489152
4TLK12.72980132
5EIF2AK32.60924972
6MAP3K102.58280755
7PBK2.53263841
8AKT32.07793669
9PKN21.97982938
10MST1R1.72571783
11CDK61.72153154
12TTN1.66559043
13CAMKK21.63355620
14BMPR21.59148898
15NEK61.54469750
16BRD41.53830689
17STK241.47522009
18MAP3K21.46422834
19BTK1.44769757
20PDGFRA1.44508635
21RPS6KB21.41877072
22TRPM71.41801340
23STK38L1.40424222
24IRAK31.39398459
25LATS11.35864985
26TRIB31.34278966
27MET1.33131478
28SRPK11.32111620
29RET1.31723348
30TSSK61.30955142
31FGFR31.30719501
32JAK11.23703536
33ERBB31.19826048
34BRSK21.18524746
35RPS6KB11.16144899
36NEK91.16014796
37TEC1.14202415
38CDC71.13897934
39MELK1.10354859
40PRPF4B1.08265696
41RPS6KA51.06357432
42STK41.04296542
43PDGFRB1.04271734
44STK31.02520363
45SGK30.94090499
46CHEK20.91355136
47NEK10.90897823
48SGK20.90701302
49PIK3CG0.89891394
50TTK0.85583054
51CCNB10.84692136
52MAP3K60.84500776
53AURKB0.83613478
54ACVR1B0.79751053
55ATR0.79729532
56RAF10.78816945
57CAMK1D0.78568034
58PIM10.77902495
59CDK80.77312853
60FRK0.76921090
61MAPK110.76826892
62ATM0.75098851
63PAK60.74345208
64RPS6KA40.72210565
65CDK40.71770487
66OBSCN0.69975860
67MAP3K40.66580023
68FGFR40.65987475
69PAK20.63959155
70PIK3CA0.62030888
71ICK0.61618038
72DAPK30.59767377
73MAP3K120.59497759
74VRK10.59474085
75FER0.59170632
76CDK120.59092119
77KSR10.58914127
78MAP3K140.58362700
79TIE10.57876234
80KSR20.56967594
81MTOR0.56872835
82CHEK10.53810678
83JAK20.52967725
84CAMKK10.52593551
85BRAF0.50695222
86CAMK1G0.48861988
87LATS20.47085658
88PLK40.44159576
89BUB10.43199219
90HCK0.41772997
91BLK0.40771907
92NLK0.40043051
93EGFR0.39596486
94SGK4940.38929698
95SGK2230.38929698
96IRAK20.37451470
97CSNK1D0.36842539
98NEK20.36239943
99EIF2AK20.36122549
100MAP2K30.35753606

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.88752505
2Alcoholism_Homo sapiens_hsa050344.18318499
3Non-homologous end-joining_Homo sapiens_hsa034502.75873034
4Viral carcinogenesis_Homo sapiens_hsa052032.35168683
5Non-small cell lung cancer_Homo sapiens_hsa052232.13256631
6Thyroid cancer_Homo sapiens_hsa052161.94491534
7Chronic myeloid leukemia_Homo sapiens_hsa052201.83485930
8Small cell lung cancer_Homo sapiens_hsa052221.73005953
9Glioma_Homo sapiens_hsa052141.68404702
10Pancreatic cancer_Homo sapiens_hsa052121.68126355
11Cell cycle_Homo sapiens_hsa041101.59193615
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53709152
13MicroRNAs in cancer_Homo sapiens_hsa052061.51661275
14Inositol phosphate metabolism_Homo sapiens_hsa005621.48239355
15Endometrial cancer_Homo sapiens_hsa052131.47804729
16mTOR signaling pathway_Homo sapiens_hsa041501.43872379
17B cell receptor signaling pathway_Homo sapiens_hsa046621.42503178
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39779127
19DNA replication_Homo sapiens_hsa030301.39023445
20Colorectal cancer_Homo sapiens_hsa052101.39023232
21Proteoglycans in cancer_Homo sapiens_hsa052051.32470837
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26928822
23ErbB signaling pathway_Homo sapiens_hsa040121.24502771
24Renal cell carcinoma_Homo sapiens_hsa052111.20154219
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19525771
26Fanconi anemia pathway_Homo sapiens_hsa034601.17789570
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17508465
28TGF-beta signaling pathway_Homo sapiens_hsa043501.15804462
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.13481171
30Prolactin signaling pathway_Homo sapiens_hsa049171.11431149
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10803894
32Bladder cancer_Homo sapiens_hsa052191.07148561
33Prostate cancer_Homo sapiens_hsa052151.04177876
34Mismatch repair_Homo sapiens_hsa034301.01876722
35ECM-receptor interaction_Homo sapiens_hsa045120.99731131
36p53 signaling pathway_Homo sapiens_hsa041150.99483628
37Focal adhesion_Homo sapiens_hsa045100.98696422
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98551066
39FoxO signaling pathway_Homo sapiens_hsa040680.97992032
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96009042
41Neurotrophin signaling pathway_Homo sapiens_hsa047220.95968787
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95958810
43Adherens junction_Homo sapiens_hsa045200.94571916
44VEGF signaling pathway_Homo sapiens_hsa043700.93131039
45Platelet activation_Homo sapiens_hsa046110.92964281
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92737906
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90891953
48Nucleotide excision repair_Homo sapiens_hsa034200.89927566
49HIF-1 signaling pathway_Homo sapiens_hsa040660.89578136
50Acute myeloid leukemia_Homo sapiens_hsa052210.89144770
51Hepatitis B_Homo sapiens_hsa051610.87236423
52Melanoma_Homo sapiens_hsa052180.85914563
53Toxoplasmosis_Homo sapiens_hsa051450.82879086
54Pathways in cancer_Homo sapiens_hsa052000.79095217
55HTLV-I infection_Homo sapiens_hsa051660.78378208
56Hippo signaling pathway_Homo sapiens_hsa043900.76550299
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76041613
58Choline metabolism in cancer_Homo sapiens_hsa052310.75223993
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.74917485
60Apoptosis_Homo sapiens_hsa042100.74784755
61Renin-angiotensin system_Homo sapiens_hsa046140.73889400
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.70718220
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70127637
64Influenza A_Homo sapiens_hsa051640.67658426
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.67069362
66Measles_Homo sapiens_hsa051620.65208672
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64810170
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.63581575
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62961223
70RNA transport_Homo sapiens_hsa030130.62839377
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60342999
72Lysine degradation_Homo sapiens_hsa003100.58460599
73N-Glycan biosynthesis_Homo sapiens_hsa005100.58090901
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57619034
75GnRH signaling pathway_Homo sapiens_hsa049120.57516680
76Type II diabetes mellitus_Homo sapiens_hsa049300.57320385
77Other glycan degradation_Homo sapiens_hsa005110.56495991
78Insulin signaling pathway_Homo sapiens_hsa049100.56028230
79Dorso-ventral axis formation_Homo sapiens_hsa043200.55499375
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.55056221
81mRNA surveillance pathway_Homo sapiens_hsa030150.54462869
82Insulin resistance_Homo sapiens_hsa049310.52540893
83Osteoclast differentiation_Homo sapiens_hsa043800.52510314
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52263327
85Sphingolipid metabolism_Homo sapiens_hsa006000.52214660
86TNF signaling pathway_Homo sapiens_hsa046680.51387735
87Gap junction_Homo sapiens_hsa045400.50813991
88Legionellosis_Homo sapiens_hsa051340.50395312
89Hepatitis C_Homo sapiens_hsa051600.49906741
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49225423
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.44612299
92Leishmaniasis_Homo sapiens_hsa051400.44160545
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44098634
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43930297
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42741868
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42483360
97T cell receptor signaling pathway_Homo sapiens_hsa046600.41808814
98Estrogen signaling pathway_Homo sapiens_hsa049150.40455378
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38150209
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37477395

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