ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytoplasmic mRNA processing body assembly (GO:0033962)	6.98916487
2	nucleoside diphosphate catabolic process (GO:0009134)	6.17160139
3	exocrine pancreas development (GO:0031017)	5.35129895
4	acrosome assembly (GO:0001675)	4.80478988
5	regulation of memory T cell differentiation (GO:0043380)	4.63212019
6	negative regulation of multicellular organism growth (GO:0040015)	4.60673967
7	stress granule assembly (GO:0034063)	4.55214048
8	regulation of establishment of cell polarity (GO:2000114)	4.52420908
9	central nervous system neuron axonogenesis (GO:0021955)	4.47698619
10	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.36928943
11	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.36928943
12	regulation of translation, ncRNA-mediated (GO:0045974)	4.36928943
13	central nervous system projection neuron axonogenesis (GO:0021952)	4.31781781
14	kynurenine metabolic process (GO:0070189)	4.28381545
15	protein K11-linked deubiquitination (GO:0035871)	4.22750497
16	tryptophan catabolic process (GO:0006569)	4.22110822
17	indole-containing compound catabolic process (GO:0042436)	4.22110822
18	indolalkylamine catabolic process (GO:0046218)	4.22110822
19	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	4.09203129
20	sex differentiation (GO:0007548)	3.96442807
21	long term synaptic depression (GO:0060292)	3.86263432
22	regulation of MHC class I biosynthetic process (GO:0045343)	3.85987542
23	regulation of telomere maintenance via telomerase (GO:0032210)	3.70087661
24	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.68678024
25	DNA demethylation (GO:0080111)	3.67624704
26	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.60220891
27	spermatid nucleus differentiation (GO:0007289)	3.57153138
28	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.50127552
29	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.50127552
30	membrane repolarization during action potential (GO:0086011)	3.47205180
31	L-fucose catabolic process (GO:0042355)	3.44938516
32	fucose catabolic process (GO:0019317)	3.44938516
33	L-fucose metabolic process (GO:0042354)	3.44938516
34	positive regulation of heat generation (GO:0031652)	3.43592084
35	alternative mRNA splicing, via spliceosome (GO:0000380)	3.41769975
36	potassium ion export (GO:0071435)	3.29725048
37	neuronal action potential propagation (GO:0019227)	3.27304713
38	inositol phosphate catabolic process (GO:0071545)	3.19881056
39	dendritic spine morphogenesis (GO:0060997)	3.19521712
40	protein K48-linked deubiquitination (GO:0071108)	3.19509022
41	centrosome duplication (GO:0051298)	3.17468643
42	tryptophan metabolic process (GO:0006568)	3.17194384
43	cerebellar Purkinje cell differentiation (GO:0021702)	3.13718671
44	regulation of RNA export from nucleus (GO:0046831)	3.10791455
45	regulation of posttranscriptional gene silencing (GO:0060147)	3.00733481
46	regulation of gene silencing by miRNA (GO:0060964)	3.00733481
47	regulation of gene silencing by RNA (GO:0060966)	3.00733481
48	regulation of collateral sprouting (GO:0048670)	2.99658224
49	negative regulation of dendrite development (GO:2000171)	2.94841333
50	protein prenylation (GO:0018342)	2.93014443
51	prenylation (GO:0097354)	2.93014443
52	heparin metabolic process (GO:0030202)	2.90858721
53	heparin biosynthetic process (GO:0030210)	2.90858721
54	pre-miRNA processing (GO:0031054)	2.90624684
55	histone H3-K9 methylation (GO:0051567)	2.88799245
56	regulation of hexokinase activity (GO:1903299)	2.88597089
57	regulation of glucokinase activity (GO:0033131)	2.88597089
58	regulation of action potential (GO:0098900)	2.86206677
59	lactate metabolic process (GO:0006089)	2.85501594
60	neural tube formation (GO:0001841)	2.84795636
61	lipid particle organization (GO:0034389)	2.84577945
62	regulation of telomere maintenance (GO:0032204)	2.84453344
63	negative regulation of mast cell activation (GO:0033004)	2.83989968
64	regulation of heat generation (GO:0031650)	2.81787742
65	cilium or flagellum-dependent cell motility (GO:0001539)	2.78356718
66	DNA dealkylation (GO:0035510)	2.77952637
67	negative regulation of type 2 immune response (GO:0002829)	2.76777622
68	histone H3-K4 trimethylation (GO:0080182)	2.75963668
69	chemosensory behavior (GO:0007635)	2.74009041
70	indolalkylamine metabolic process (GO:0006586)	2.73272240
71	cellular ketone body metabolic process (GO:0046950)	2.72207242
72	ADP metabolic process (GO:0046031)	2.72069335
73	magnesium ion transport (GO:0015693)	2.71740971
74	response to misfolded protein (GO:0051788)	2.71716055
75	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.65959049
76	pancreas development (GO:0031016)	2.65680204
77	signal peptide processing (GO:0006465)	2.65544656
78	DNA damage response, detection of DNA damage (GO:0042769)	2.65211474
79	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.65027430
80	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.65027430
81	protein K63-linked deubiquitination (GO:0070536)	2.64309915
82	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.61856771
83	regulation of histone H3-K9 methylation (GO:0051570)	2.61318927
84	brain morphogenesis (GO:0048854)	2.61226128
85	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.58031967
86	pericardium development (GO:0060039)	2.56900671
87	spinal cord motor neuron differentiation (GO:0021522)	2.55509819
88	dendritic spine organization (GO:0097061)	2.54947964
89	retinal ganglion cell axon guidance (GO:0031290)	2.51792593
90	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	2.50247544
91	monoubiquitinated protein deubiquitination (GO:0035520)	2.47990954
92	regulation of interleukin-13 production (GO:0032656)	2.47530796
93	nodal signaling pathway (GO:0038092)	2.45476554
94	retina layer formation (GO:0010842)	2.45451047
95	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.43786226
96	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.43786226
97	disruption of cells of other organism (GO:0044364)	2.42797913
98	killing of cells of other organism (GO:0031640)	2.42797913
99	response to dietary excess (GO:0002021)	2.42600304
100	retinal rod cell development (GO:0046548)	2.42581069

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.60823720
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.37317218
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.27878540
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.21376750
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.16693034
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.11426582
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.98189405
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.89775198
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69556952
10	EWS_26573619_Chip-Seq_HEK293_Human	2.55048305
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.41668945
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27813858
13	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.20637521
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.17478479
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.12343432
16	FUS_26573619_Chip-Seq_HEK293_Human	2.00558063
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99087869
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92375431
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.89685552
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.87077754
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.84978080
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.77735586
23	P300_19829295_ChIP-Seq_ESCs_Human	1.76451770
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.72599253
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72599253
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.71313966
27	VDR_22108803_ChIP-Seq_LS180_Human	1.70165158
28	STAT3_23295773_ChIP-Seq_U87_Human	1.67546419
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62156633
30	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61946031
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.59063580
32	AHR_22903824_ChIP-Seq_MCF-7_Human	1.57730982
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.57451891
34	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.56889095
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56656610
36	TCF4_23295773_ChIP-Seq_U87_Human	1.52415749
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.46791917
38	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.46353243
39	IGF1R_20145208_ChIP-Seq_DFB_Human	1.46112665
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46080707
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46049810
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.45579495
43	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.44190792
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.43388002
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42335298
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.41810110
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40919172
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39491519
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.39363896
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39363896
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35936999
52	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.35786248
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34636769
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.34157095
55	TP53_16413492_ChIP-PET_HCT116_Human	1.33728482
56	E2F7_22180533_ChIP-Seq_HELA_Human	1.33019672
57	AR_25329375_ChIP-Seq_VCAP_Human	1.32114249
58	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.27962783
59	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.23424991
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19484245
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18768258
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.17798650
63	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.16933645
64	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16680092
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16032107
66	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.15402680
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15055100
68	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14456363
69	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.13181573
70	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.12618774
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12387681
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12204920
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12134410
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11877041
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11596735
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11500680
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10951722
78	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10597490
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.08678091
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.08630645
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06947454
82	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.04688218
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03753874
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02609610
85	VDR_23849224_ChIP-Seq_CD4+_Human	1.01974153
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01446758
87	MYC_18940864_ChIP-ChIP_HL60_Human	1.01233821
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00751242
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00633181
90	TP53_22573176_ChIP-Seq_HFKS_Human	1.00594457
91	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00552866
92	NCOR_22424771_ChIP-Seq_293T_Human	1.00123116
93	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00077862
94	JUN_21703547_ChIP-Seq_K562_Human	0.98506444
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97971701
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97047482
97	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.96702829
98	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96626862
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96626862
100	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.96128418

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.64586386
2	MP0008057_abnormal_DNA_replication	3.75886040
3	MP0005083_abnormal_biliary_tract	3.04565846
4	MP0002837_dystrophic_cardiac_calcinosis	2.95143312
5	MP0008877_abnormal_DNA_methylation	2.92288231
6	MP0004270_analgesia	2.74443198
7	MP0005377_hearing/vestibular/ear_phenot	2.42844631
8	MP0003878_abnormal_ear_physiology	2.42844631
9	MP0003122_maternal_imprinting	2.32192030
10	MP0003787_abnormal_imprinting	2.26689675
11	MP0009046_muscle_twitch	2.24760172
12	MP0002102_abnormal_ear_morphology	2.23497128
13	MP0003718_maternal_effect	2.20248346
14	MP0003195_calcinosis	2.08318263
15	MP0004130_abnormal_muscle_cell	2.07889172
16	MP0001986_abnormal_taste_sensitivity	1.98210936
17	MP0005551_abnormal_eye_electrophysiolog	1.98058826
18	MP0008058_abnormal_DNA_repair	1.97721653
19	MP0004147_increased_porphyrin_level	1.92645613
20	MP0006072_abnormal_retinal_apoptosis	1.83182537
21	MP0002736_abnormal_nociception_after	1.70361397
22	MP0005253_abnormal_eye_physiology	1.69988232
23	MP0003890_abnormal_embryonic-extraembry	1.68893894
24	MP0003121_genomic_imprinting	1.58924375
25	MP0003011_delayed_dark_adaptation	1.56424062
26	MP0010094_abnormal_chromosome_stability	1.51129388
27	MP0000538_abnormal_urinary_bladder	1.49526048
28	MP0004133_heterotaxia	1.47380489
29	MP0002396_abnormal_hematopoietic_system	1.42732509
30	MP0004215_abnormal_myocardial_fiber	1.40242384
31	MP0003252_abnormal_bile_duct	1.37899011
32	MP0005220_abnormal_exocrine_pancreas	1.35651863
33	MP0000778_abnormal_nervous_system	1.33607704
34	MP0000427_abnormal_hair_cycle	1.28885304
35	MP0002009_preneoplasia	1.25187896
36	MP0001486_abnormal_startle_reflex	1.24822964
37	MP0001485_abnormal_pinna_reflex	1.23886940
38	MP0003880_abnormal_central_pattern	1.23685991
39	MP0006035_abnormal_mitochondrial_morpho	1.21924898
40	MP0002067_abnormal_sensory_capabilities	1.19264961
41	MP0003786_premature_aging	1.18897219
42	MP0003137_abnormal_impulse_conducting	1.16710511
43	MP0008961_abnormal_basal_metabolism	1.15530419
44	MP0001968_abnormal_touch/_nociception	1.13378254
45	MP0005451_abnormal_body_composition	1.13200812
46	MP0005084_abnormal_gallbladder_morpholo	1.12036959
47	MP0002229_neurodegeneration	1.11692861
48	MP0001661_extended_life_span	1.11648905
49	MP0009745_abnormal_behavioral_response	1.07911931
50	MP0002928_abnormal_bile_duct	1.06986310
51	MP0002938_white_spotting	1.06654389
52	MP0003646_muscle_fatigue	1.06123469
53	MP0006292_abnormal_olfactory_placode	1.04721424
54	MP0002693_abnormal_pancreas_physiology	1.02138737
55	MP0003937_abnormal_limbs/digits/tail_de	1.01819764
56	MP0005645_abnormal_hypothalamus_physiol	1.01635710
57	MP0002653_abnormal_ependyma_morphology	1.01451791
58	MP0001944_abnormal_pancreas_morphology	1.00685306
59	MP0002160_abnormal_reproductive_system	0.98721766
60	MP0008007_abnormal_cellular_replicative	0.96952478
61	MP0005395_other_phenotype	0.95813248
62	MP0005423_abnormal_somatic_nervous	0.94161221
63	MP0002064_seizures	0.93070779
64	MP0002272_abnormal_nervous_system	0.93055568
65	MP0001873_stomach_inflammation	0.91447299
66	MP0002734_abnormal_mechanical_nocicepti	0.91113721
67	MP0002084_abnormal_developmental_patter	0.90927440
68	MP0005174_abnormal_tail_pigmentation	0.89408021
69	MP0004145_abnormal_muscle_electrophysio	0.89218068
70	MP0000383_abnormal_hair_follicle	0.87843068
71	MP0001501_abnormal_sleep_pattern	0.87510849
72	MP0003635_abnormal_synaptic_transmissio	0.83601630
73	MP0006276_abnormal_autonomic_nervous	0.83501797
74	MP0002184_abnormal_innervation	0.81472751
75	MP0004924_abnormal_behavior	0.79694125
76	MP0005386_behavior/neurological_phenoty	0.79694125
77	MP0002751_abnormal_autonomic_nervous	0.79566182
78	MP0003861_abnormal_nervous_system	0.75829324
79	MP0003385_abnormal_body_wall	0.75222710
80	MP0002572_abnormal_emotion/affect_behav	0.75045063
81	MP0005334_abnormal_fat_pad	0.74840276
82	MP0005266_abnormal_metabolism	0.74590394
83	MP0001984_abnormal_olfaction	0.74024770
84	MP0005391_vision/eye_phenotype	0.73900956
85	MP0003123_paternal_imprinting	0.72721306
86	MP0002078_abnormal_glucose_homeostasis	0.71571414
87	MP0002882_abnormal_neuron_morphology	0.70325931
88	MP0004742_abnormal_vestibular_system	0.70231526
89	MP0004233_abnormal_muscle_weight	0.70009795
90	MP0002638_abnormal_pupillary_reflex	0.68432007
91	MP0003119_abnormal_digestive_system	0.67433735
92	MP0002063_abnormal_learning/memory/cond	0.67302257
93	MP0002752_abnormal_somatic_nervous	0.67141457
94	MP0003656_abnormal_erythrocyte_physiolo	0.66883508
95	MP0001502_abnormal_circadian_rhythm	0.66210939
96	MP0000371_diluted_coat_color	0.66010982
97	MP0003950_abnormal_plasma_membrane	0.65791223
98	MP0005195_abnormal_posterior_eye	0.65786711
99	MP0000955_abnormal_spinal_cord	0.65295154
100	MP0000358_abnormal_cell_content/	0.64804906

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	6.23123571
2	Progressive cerebellar ataxia (HP:0002073)	4.85407475
3	Dysmetric saccades (HP:0000641)	4.24826615
4	Clumsiness (HP:0002312)	3.72153054
5	Urinary bladder sphincter dysfunction (HP:0002839)	3.67875255
6	Hyperventilation (HP:0002883)	3.64000532
7	Birth length less than 3rd percentile (HP:0003561)	3.61100645
8	Action tremor (HP:0002345)	3.44794155
9	Molar tooth sign on MRI (HP:0002419)	3.43802662
10	Abnormality of midbrain morphology (HP:0002418)	3.43802662
11	Impaired smooth pursuit (HP:0007772)	3.21427023
12	Protruding tongue (HP:0010808)	3.19932487
13	Gaze-evoked nystagmus (HP:0000640)	2.96308372
14	Neoplasm of the adrenal cortex (HP:0100641)	2.90911745
15	Abnormality of the hepatic vasculature (HP:0006707)	2.82636366
16	Impaired vibratory sensation (HP:0002495)	2.79889018
17	Fair hair (HP:0002286)	2.57844285
18	Dialeptic seizures (HP:0011146)	2.53620722
19	Short chin (HP:0000331)	2.52483556
20	Absence seizures (HP:0002121)	2.52268174
21	Pancreatic cysts (HP:0001737)	2.49633962
22	Medial flaring of the eyebrow (HP:0010747)	2.41193849
23	Pancreatic fibrosis (HP:0100732)	2.36347143
24	Colon cancer (HP:0003003)	2.33493159
25	Prostate neoplasm (HP:0100787)	2.33300584
26	Progressive inability to walk (HP:0002505)	2.32325678
27	Abnormality of subcutaneous fat tissue (HP:0001001)	2.28832236
28	Gait imbalance (HP:0002141)	2.27656506
29	Abnormality of ocular smooth pursuit (HP:0000617)	2.26426022
30	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.24184677
31	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.24184677
32	Hypoplasia of the pons (HP:0012110)	2.23884307
33	Chronic hepatic failure (HP:0100626)	2.23193885
34	Abnormality of the pons (HP:0007361)	2.21024945
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20843183
36	Absent/shortened dynein arms (HP:0200106)	2.20843183
37	Inability to walk (HP:0002540)	2.20711399
38	Tubulointerstitial nephritis (HP:0001970)	2.20684660
39	Large for gestational age (HP:0001520)	2.19976776
40	Thrombocytosis (HP:0001894)	2.19545616
41	Ventricular fibrillation (HP:0001663)	2.16402425
42	Patellar aplasia (HP:0006443)	2.15666300
43	Congenital primary aphakia (HP:0007707)	2.15167550
44	Abnormality of vision evoked potentials (HP:0000649)	2.14785419
45	Hypsarrhythmia (HP:0002521)	2.14085298
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.12676401
47	Abnormality of the labia minora (HP:0012880)	2.12002144
48	Genital tract atresia (HP:0001827)	2.11254753
49	Neonatal hypoglycemia (HP:0001998)	2.11194393
50	Labial hypoplasia (HP:0000066)	2.10822473
51	Focal seizures (HP:0007359)	2.10518707
52	Optic nerve hypoplasia (HP:0000609)	2.09830063
53	EEG with generalized epileptiform discharges (HP:0011198)	2.06435489
54	Nephronophthisis (HP:0000090)	2.05021416
55	True hermaphroditism (HP:0010459)	2.03890195
56	Oculomotor apraxia (HP:0000657)	2.01313664
57	Dysdiadochokinesis (HP:0002075)	2.01109094
58	Pendular nystagmus (HP:0012043)	2.00961451
59	Epileptiform EEG discharges (HP:0011182)	2.00600431
60	Absent speech (HP:0001344)	2.00237998
61	Abolished electroretinogram (ERG) (HP:0000550)	1.97642686
62	Abnormality of the corticospinal tract (HP:0002492)	1.96783857
63	Febrile seizures (HP:0002373)	1.95905012
64	Retinal dysplasia (HP:0007973)	1.95889114
65	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.94700583
66	Vaginal atresia (HP:0000148)	1.94476998
67	Rhabdomyosarcoma (HP:0002859)	1.94042819
68	Lissencephaly (HP:0001339)	1.93990266
69	Poor coordination (HP:0002370)	1.93855358
70	Hypothermia (HP:0002045)	1.93607130
71	Aplasia/Hypoplasia of the patella (HP:0006498)	1.93157934
72	Abnormality of the astrocytes (HP:0100707)	1.93110045
73	Astrocytoma (HP:0009592)	1.93110045
74	Broad-based gait (HP:0002136)	1.92007720
75	Type I diabetes mellitus (HP:0100651)	1.90920257
76	Limb ataxia (HP:0002070)	1.90245951
77	Generalized hypopigmentation of hair (HP:0011358)	1.87404831
78	Drooling (HP:0002307)	1.86849184
79	Bifid tongue (HP:0010297)	1.86452593
80	Abnormality of the prostate (HP:0008775)	1.85982313
81	Chromsome breakage (HP:0040012)	1.84711120
82	Polymicrogyria (HP:0002126)	1.83190648
83	Glioma (HP:0009733)	1.82648921
84	Abnormal biliary tract physiology (HP:0012439)	1.82437618
85	Bile duct proliferation (HP:0001408)	1.82437618
86	Hypoplastic female external genitalia (HP:0012815)	1.82240386
87	Hypomagnesemia (HP:0002917)	1.82190278
88	Hemiparesis (HP:0001269)	1.80031072
89	Nephrogenic diabetes insipidus (HP:0009806)	1.78842566
90	Morphological abnormality of the pyramidal tract (HP:0002062)	1.76379105
91	Abnormal protein glycosylation (HP:0012346)	1.76271740
92	Abnormal glycosylation (HP:0012345)	1.76271740
93	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.76271740
94	Abnormal protein N-linked glycosylation (HP:0012347)	1.76271740
95	Oligodactyly (hands) (HP:0001180)	1.75845302
96	Highly arched eyebrow (HP:0002553)	1.75801320
97	Abnormal hair whorl (HP:0010721)	1.75248141
98	Sloping forehead (HP:0000340)	1.72737274
99	Abnormal ciliary motility (HP:0012262)	1.72186784
100	Abnormal respiratory motile cilium physiology (HP:0012261)	1.71927477

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.78093217
2	ACVR1B	3.14084059
3	CDK19	3.07922857
4	TRIM28	2.71961997
5	BMPR1B	2.59341840
6	ZAK	2.52342091
7	CAMK1D	2.34309588
8	OXSR1	2.07228966
9	BCR	2.05479002
10	MARK1	2.05130284
11	GRK1	1.90762944
12	AKT3	1.86177257
13	FGFR2	1.74919827
14	CAMK1G	1.61391368
15	CDK12	1.60405259
16	MKNK2	1.55178351
17	TSSK6	1.50809924
18	CSNK1A1L	1.44190514
19	CSNK1G1	1.41436048
20	WNK3	1.29994473
21	SRPK1	1.28806273
22	PDK2	1.22851721
23	BRD4	1.20599819
24	SGK2	1.19014412
25	MAP3K4	1.18804166
26	PLK4	1.14616909
27	EPHA4	1.13938016
28	CSNK1G3	1.11696459
29	NUAK1	1.11088661
30	MAP2K7	1.10500432
31	SIK2	1.09741682
32	CAMKK2	1.05742356
33	TGFBR1	1.01868707
34	PLK3	0.99175302
35	NLK	0.95052486
36	PLK2	0.94394109
37	MKNK1	0.94217581
38	GRK7	0.91845005
39	CSNK1G2	0.89214144
40	TNK2	0.82809149
41	BRSK2	0.80322331
42	ATR	0.78833691
43	PRKAA1	0.77834478
44	SGK223	0.75757794
45	SGK494	0.75757794
46	TTK	0.74071646
47	TEC	0.73731041
48	ATM	0.73143257
49	FLT3	0.72995054
50	PAK3	0.69975959
51	ALK	0.69303955
52	EPHB1	0.68702254
53	FER	0.66838303
54	MATK	0.66814099
55	RPS6KA5	0.63451046
56	PLK1	0.62086839
57	ADRBK2	0.61296012
58	VRK1	0.60916632
59	CHEK1	0.59453311
60	STK11	0.58552741
61	BCKDK	0.56432122
62	PNCK	0.55613438
63	MTOR	0.51899165
64	TESK2	0.50732925
65	MST4	0.49599604
66	ADRBK1	0.49265125
67	CCNB1	0.48601624
68	ERBB3	0.46657938
69	CHEK2	0.46350006
70	PRKCZ	0.46288098
71	TNIK	0.45690610
72	INSRR	0.45098400
73	PRKAA2	0.44585613
74	RPS6KA4	0.43503941
75	EIF2AK1	0.42674477
76	MAP3K10	0.42614284
77	PRKCE	0.42457979
78	SGK3	0.41696140
79	AURKA	0.41562330
80	TXK	0.41080333
81	MAPK13	0.40849607
82	PIM2	0.39315584
83	PINK1	0.38823626
84	KIT	0.37901692
85	PKN1	0.37865594
86	NEK2	0.37538219
87	YES1	0.36082562
88	NEK1	0.35836115
89	DAPK2	0.35497740
90	BUB1	0.34962371
91	WNK4	0.34801396
92	PTK2B	0.34154829
93	CDC7	0.33734637
94	MAPK15	0.32987918
95	CSNK1D	0.32473975
96	TAOK3	0.32472806
97	EPHA3	0.31195481
98	CAMK4	0.30902501
99	PDK1	0.30890502
100	STK38	0.30851042

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.14733593
2	Butanoate metabolism_Homo sapiens_hsa00650	3.04008106
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.95394116
4	RNA polymerase_Homo sapiens_hsa03020	2.93556144
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.53587748
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.31203236
7	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.27982394
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.08091691
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.02778385
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.95695733
11	Nicotine addiction_Homo sapiens_hsa05033	1.94426821
12	Fatty acid elongation_Homo sapiens_hsa00062	1.82706060
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.77984049
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.69041834
15	Phototransduction_Homo sapiens_hsa04744	1.67123279
16	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.66267132
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.64143755
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.61426898
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58467373
20	Propanoate metabolism_Homo sapiens_hsa00640	1.56521376
21	Olfactory transduction_Homo sapiens_hsa04740	1.56476605
22	One carbon pool by folate_Homo sapiens_hsa00670	1.55173750
23	Circadian rhythm_Homo sapiens_hsa04710	1.48058475
24	Lysine degradation_Homo sapiens_hsa00310	1.44171178
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.42031296
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.33900978
27	mTOR signaling pathway_Homo sapiens_hsa04150	1.33882932
28	Homologous recombination_Homo sapiens_hsa03440	1.24704116
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24614851
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24137484
31	Morphine addiction_Homo sapiens_hsa05032	1.19072939
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.17640805
33	Caffeine metabolism_Homo sapiens_hsa00232	1.16023714
34	Alcoholism_Homo sapiens_hsa05034	1.15486758
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.13865690
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.13805422
37	Taste transduction_Homo sapiens_hsa04742	1.12264337
38	Oocyte meiosis_Homo sapiens_hsa04114	1.11245159
39	Basal transcription factors_Homo sapiens_hsa03022	1.05793289
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04704725
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04624190
42	ABC transporters_Homo sapiens_hsa02010	1.03704499
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.03306323
44	Insulin secretion_Homo sapiens_hsa04911	1.01811229
45	GABAergic synapse_Homo sapiens_hsa04727	0.98872572
46	Type II diabetes mellitus_Homo sapiens_hsa04930	0.98862800
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.98387979
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.96632353
49	Long-term depression_Homo sapiens_hsa04730	0.96523558
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96170623
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94138595
52	RNA transport_Homo sapiens_hsa03013	0.93095497
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.90841695
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.89304105
55	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.88361763
56	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.87196751
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.85632687
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84809810
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82528903
60	Asthma_Homo sapiens_hsa05310	0.82079184
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.80845907
62	Purine metabolism_Homo sapiens_hsa00230	0.79800841
63	Circadian entrainment_Homo sapiens_hsa04713	0.78181181
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77664820
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.74990402
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.73460300
67	Base excision repair_Homo sapiens_hsa03410	0.72359320
68	RNA degradation_Homo sapiens_hsa03018	0.71509634
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71275917
70	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.68957827
71	Cell cycle_Homo sapiens_hsa04110	0.68180418
72	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.67361285
73	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66437520
74	Salivary secretion_Homo sapiens_hsa04970	0.65142247
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.64384766
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63945913
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.63790120
78	Regulation of autophagy_Homo sapiens_hsa04140	0.61884399
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.55840545
80	Fatty acid degradation_Homo sapiens_hsa00071	0.55336541
81	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.52884029
82	Retinol metabolism_Homo sapiens_hsa00830	0.51385181
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51174938
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.48471082
85	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.47107753
86	Dopaminergic synapse_Homo sapiens_hsa04728	0.45533659
87	Insulin resistance_Homo sapiens_hsa04931	0.42859568
88	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.41979560
89	Gastric acid secretion_Homo sapiens_hsa04971	0.39680339
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38025349
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.36793860
92	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.35757421
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.33988945
94	AMPK signaling pathway_Homo sapiens_hsa04152	0.33884702
95	Tight junction_Homo sapiens_hsa04530	0.30526035
96	Serotonergic synapse_Homo sapiens_hsa04726	0.30107036
97	Metabolic pathways_Homo sapiens_hsa01100	0.28936752
98	Peroxisome_Homo sapiens_hsa04146	0.27335577
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.27095997
100	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26169516

RIMKLBP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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