ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.01370506
2	platelet dense granule organization (GO:0060155)	4.83783597
3	replication fork processing (GO:0031297)	4.27134607
4	lactate metabolic process (GO:0006089)	4.24000767
5	fucose catabolic process (GO:0019317)	3.99022373
6	L-fucose metabolic process (GO:0042354)	3.99022373
7	L-fucose catabolic process (GO:0042355)	3.99022373
8	protein prenylation (GO:0018342)	3.98469169
9	prenylation (GO:0097354)	3.98469169
10	DNA double-strand break processing (GO:0000729)	3.90911450
11	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.89762929
12	protein K11-linked deubiquitination (GO:0035871)	3.68540526
13	cellular ketone body metabolic process (GO:0046950)	3.63102583
14	ketone body metabolic process (GO:1902224)	3.62738213
15	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.61928340
16	branched-chain amino acid catabolic process (GO:0009083)	3.60423892
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.52046980
18	axoneme assembly (GO:0035082)	3.46006172
19	respiratory chain complex IV assembly (GO:0008535)	3.43766872
20	proteasome assembly (GO:0043248)	3.42296229
21	regulation of glucokinase activity (GO:0033131)	3.34679584
22	regulation of hexokinase activity (GO:1903299)	3.34679584
23	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.30283825
24	auditory receptor cell differentiation (GO:0042491)	3.27360650
25	retinal cone cell development (GO:0046549)	3.26561713
26	phospholipid homeostasis (GO:0055091)	3.22646589
27	double-strand break repair via homologous recombination (GO:0000724)	3.22594861
28	recombinational repair (GO:0000725)	3.17074510
29	photoreceptor cell maintenance (GO:0045494)	3.16872979
30	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.16179526
31	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.16179526
32	male meiosis (GO:0007140)	3.12710813
33	regulation of meiosis I (GO:0060631)	3.11970018
34	regulation of protein glycosylation (GO:0060049)	3.10654374
35	intraciliary transport (GO:0042073)	3.07478858
36	synapsis (GO:0007129)	3.04663851
37	histone mRNA catabolic process (GO:0071044)	3.03892463
38	cytochrome complex assembly (GO:0017004)	2.99862531
39	postreplication repair (GO:0006301)	2.99764580
40	signal peptide processing (GO:0006465)	2.99420312
41	keratinocyte development (GO:0003334)	2.97948027
42	reciprocal meiotic recombination (GO:0007131)	2.97818802
43	reciprocal DNA recombination (GO:0035825)	2.97818802
44	mannosylation (GO:0097502)	2.96306166
45	aldehyde catabolic process (GO:0046185)	2.92391057
46	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.91561337
47	regulation of response to food (GO:0032095)	2.91168931
48	regulation of centrosome duplication (GO:0010824)	2.89249423
49	inner ear receptor cell differentiation (GO:0060113)	2.88320629
50	inositol phosphate catabolic process (GO:0071545)	2.83343143
51	response to nitrosative stress (GO:0051409)	2.83069123
52	histone H2A acetylation (GO:0043968)	2.82126233
53	resolution of meiotic recombination intermediates (GO:0000712)	2.81043583
54	adenosine metabolic process (GO:0046085)	2.80141019
55	maturation of 5.8S rRNA (GO:0000460)	2.73383190
56	cilium organization (GO:0044782)	2.72452311
57	reflex (GO:0060004)	2.71458255
58	branched-chain amino acid metabolic process (GO:0009081)	2.71235397
59	cilium morphogenesis (GO:0060271)	2.71063755
60	peroxisome fission (GO:0016559)	2.70717768
61	protein K6-linked ubiquitination (GO:0085020)	2.66471524
62	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.66028470
63	isotype switching (GO:0045190)	2.66028470
64	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.66028470
65	S-adenosylmethionine metabolic process (GO:0046500)	2.64613635
66	cilium assembly (GO:0042384)	2.64518292
67	epithelial cilium movement (GO:0003351)	2.63754628
68	DNA catabolic process, exonucleolytic (GO:0000738)	2.63303587
69	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.62939235
70	pancreas development (GO:0031016)	2.62360241
71	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.61867514
72	auditory receptor cell stereocilium organization (GO:0060088)	2.61303570
73	regulation of sulfur metabolic process (GO:0042762)	2.59097980
74	zinc ion transport (GO:0006829)	2.57196379
75	regulation of relaxation of muscle (GO:1901077)	2.55887712
76	anterograde synaptic vesicle transport (GO:0048490)	2.55790608
77	piRNA metabolic process (GO:0034587)	2.54139181
78	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.52988562
79	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.50325852
80	xenobiotic catabolic process (GO:0042178)	2.48374791
81	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.47897350
82	regulation of mitotic spindle checkpoint (GO:1903504)	2.47897350
83	C-terminal protein amino acid modification (GO:0018410)	2.47015431
84	C-terminal protein lipidation (GO:0006501)	2.46951561
85	regulation of centrosome cycle (GO:0046605)	2.45897197
86	cullin deneddylation (GO:0010388)	2.45451341
87	nonmotile primary cilium assembly (GO:0035058)	2.44559130
88	peptidyl-histidine modification (GO:0018202)	2.43347827
89	methionine biosynthetic process (GO:0009086)	2.43143796
90	limb bud formation (GO:0060174)	2.42908582
91	protein complex biogenesis (GO:0070271)	2.42701716
92	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.42548466
93	centriole replication (GO:0007099)	2.42389071
94	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.42206404
95	prostate gland growth (GO:0060736)	2.42046017
96	cyclic nucleotide catabolic process (GO:0009214)	2.40009558
97	hair cell differentiation (GO:0035315)	2.39593351
98	dentate gyrus development (GO:0021542)	2.38663749
99	positive regulation of protein autophosphorylation (GO:0031954)	2.38617357
100	response to redox state (GO:0051775)	2.36583559

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.20004097
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.16189304
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.97702531
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.70476593
5	FUS_26573619_Chip-Seq_HEK293_Human	2.69985239
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69523004
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.64241596
8	VDR_22108803_ChIP-Seq_LS180_Human	2.55457691
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.51657424
10	EWS_26573619_Chip-Seq_HEK293_Human	2.31855443
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.26322792
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24248889
13	P300_19829295_ChIP-Seq_ESCs_Human	2.19237480
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.17513768
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.13079229
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.05859071
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.91413168
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81024302
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.80548820
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73911340
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.71261332
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.70292039
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.68843874
24	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.67606492
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65939356
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.64967392
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64430806
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.63003426
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62832768
30	E2F7_22180533_ChIP-Seq_HELA_Human	1.61444964
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58336457
32	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.56188007
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55728315
34	STAT3_23295773_ChIP-Seq_U87_Human	1.55156155
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54777856
36	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47794317
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.47687938
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.47542687
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.47019497
40	AR_25329375_ChIP-Seq_VCAP_Human	1.45792832
41	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.45581502
42	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.44596384
43	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.43334026
44	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.43173570
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42955644
46	TCF4_23295773_ChIP-Seq_U87_Human	1.42783400
47	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.42577110
48	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.41273025
49	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.40875252
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40814415
51	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40390084
52	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.39198874
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.34740343
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34618151
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.33155434
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32962966
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32599985
58	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30467399
59	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.30069013
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29355041
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.29355041
62	VDR_23849224_ChIP-Seq_CD4+_Human	1.29346793
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29159117
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28618046
65	P53_22387025_ChIP-Seq_ESCs_Mouse	1.28104302
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27963735
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27963735
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24762841
69	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.23418920
70	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.23337768
71	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.22751918
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22235865
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21843615
74	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.21235713
75	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.21235713
76	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20878169
77	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.20468665
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.19329319
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17926263
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16769047
81	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.16737534
82	FOXP3_21729870_ChIP-Seq_TREG_Human	1.16670009
83	TP53_16413492_ChIP-PET_HCT116_Human	1.15939215
84	TP53_22573176_ChIP-Seq_HFKS_Human	1.15623003
85	MYC_18940864_ChIP-ChIP_HL60_Human	1.15545210
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15094755
87	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.14815395
88	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14029984
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14002196
90	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.09433821
91	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09127271
92	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.08604491
93	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.08161943
94	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07665883
95	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.07493385
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06608877
97	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.06052493
98	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.05567166
99	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.05128204
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03599322

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	5.00315966
2	MP0000569_abnormal_digit_pigmentation	4.58254657
3	MP0005174_abnormal_tail_pigmentation	3.89000785
4	MP0002938_white_spotting	3.03702596
5	MP0008877_abnormal_DNA_methylation	3.02933923
6	MP0008057_abnormal_DNA_replication	2.82910663
7	MP0003195_calcinosis	2.61838974
8	MP0000015_abnormal_ear_pigmentation	2.60310796
9	MP0006054_spinal_hemorrhage	2.52174537
10	MP0004147_increased_porphyrin_level	2.51925368
11	MP0005075_abnormal_melanosome_morpholog	2.50091283
12	MP0005408_hypopigmentation	2.37045406
13	MP0002095_abnormal_skin_pigmentation	2.33857802
14	MP0005646_abnormal_pituitary_gland	2.31871136
15	MP0001661_extended_life_span	2.11358442
16	MP0002102_abnormal_ear_morphology	2.03414668
17	MP0008058_abnormal_DNA_repair	2.02313099
18	MP0006072_abnormal_retinal_apoptosis	1.99971747
19	MP0005551_abnormal_eye_electrophysiolog	1.96687036
20	MP0008775_abnormal_heart_ventricle	1.92721990
21	MP0003646_muscle_fatigue	1.90777806
22	MP0010094_abnormal_chromosome_stability	1.87800845
23	MP0005171_absent_coat_pigmentation	1.81626067
24	MP0000383_abnormal_hair_follicle	1.74139574
25	MP0005248_abnormal_Harderian_gland	1.66952353
26	MP0005253_abnormal_eye_physiology	1.64978873
27	MP0000427_abnormal_hair_cycle	1.63348745
28	MP0009780_abnormal_chondrocyte_physiolo	1.56258121
29	MP0010678_abnormal_skin_adnexa	1.54082224
30	MP0003806_abnormal_nucleotide_metabolis	1.52642846
31	MP0005367_renal/urinary_system_phenotyp	1.51460431
32	MP0000516_abnormal_urinary_system	1.51460431
33	MP0006292_abnormal_olfactory_placode	1.50773612
34	MP0008995_early_reproductive_senescence	1.48848050
35	MP0003786_premature_aging	1.48711405
36	MP0000371_diluted_coat_color	1.35008004
37	MP0003718_maternal_effect	1.34646998
38	MP0004215_abnormal_myocardial_fiber	1.30160328
39	MP0000358_abnormal_cell_content/	1.26978366
40	MP0001501_abnormal_sleep_pattern	1.26763900
41	MP0002638_abnormal_pupillary_reflex	1.25069856
42	MP0006035_abnormal_mitochondrial_morpho	1.24724478
43	MP0000647_abnormal_sebaceous_gland	1.23758424
44	MP0003136_yellow_coat_color	1.22550554
45	MP0002837_dystrophic_cardiac_calcinosis	1.21786249
46	MP0003186_abnormal_redox_activity	1.21657136
47	MP0001984_abnormal_olfaction	1.17570999
48	MP0002090_abnormal_vision	1.15645627
49	MP0002254_reproductive_system_inflammat	1.12599452
50	MP0005220_abnormal_exocrine_pancreas	1.11371796
51	MP0000639_abnormal_adrenal_gland	1.11340767
52	MP0009046_muscle_twitch	1.10658105
53	MP0001764_abnormal_homeostasis	1.09234209
54	MP0005187_abnormal_penis_morphology	1.09029098
55	MP0002127_abnormal_cardiovascular_syste	1.08636963
56	MP0005410_abnormal_fertilization	1.08502059
57	MP0000631_abnormal_neuroendocrine_gland	1.05314104
58	MP0009697_abnormal_copulation	1.02542203
59	MP0002736_abnormal_nociception_after	1.00099251
60	MP0001929_abnormal_gametogenesis	0.99039403
61	MP0002282_abnormal_trachea_morphology	0.98341181
62	MP0005395_other_phenotype	0.96674856
63	MP0002075_abnormal_coat/hair_pigmentati	0.94988913
64	MP0001324_abnormal_eye_pigmentation	0.93732407
65	MP0010307_abnormal_tumor_latency	0.91000231
66	MP0005084_abnormal_gallbladder_morpholo	0.89325110
67	MP0000653_abnormal_sex_gland	0.88080517
68	MP0002234_abnormal_pharynx_morphology	0.87950571
69	MP0001119_abnormal_female_reproductive	0.83506672
70	MP0002168_other_aberrant_phenotype	0.82997322
71	MP0005266_abnormal_metabolism	0.82137160
72	MP0002210_abnormal_sex_determination	0.81538377
73	MP0003880_abnormal_central_pattern	0.81368702
74	MP0004133_heterotaxia	0.80908584
75	MP0004145_abnormal_muscle_electrophysio	0.79570460
76	MP0008872_abnormal_physiological_respon	0.78416918
77	MP0001145_abnormal_male_reproductive	0.77091621
78	MP0005195_abnormal_posterior_eye	0.76741053
79	MP0005332_abnormal_amino_acid	0.76015969
80	MP0005310_abnormal_salivary_gland	0.75177669
81	MP0002751_abnormal_autonomic_nervous	0.73774905
82	MP0003698_abnormal_male_reproductive	0.72986511
83	MP0005389_reproductive_system_phenotype	0.71963899
84	MP0005645_abnormal_hypothalamus_physiol	0.71061218
85	MP0002160_abnormal_reproductive_system	0.70633005
86	MP0005636_abnormal_mineral_homeostasis	0.70112382
87	MP0003868_abnormal_feces_composition	0.69894069
88	MP0002233_abnormal_nose_morphology	0.69654709
89	MP0003941_abnormal_skin_development	0.68283531
90	MP0006036_abnormal_mitochondrial_physio	0.68156265
91	MP0010329_abnormal_lipoprotein_level	0.67385205
92	MP0001486_abnormal_startle_reflex	0.66028443
93	MP0001293_anophthalmia	0.64182845
94	MP0003937_abnormal_limbs/digits/tail_de	0.64001294
95	MP0004085_abnormal_heartbeat	0.63906376
96	MP0008932_abnormal_embryonic_tissue	0.63592859
97	MP0001529_abnormal_vocalization	0.63546550
98	MP0002132_abnormal_respiratory_system	0.63356174
99	MP0002177_abnormal_outer_ear	0.63033136
100	MP0005397_hematopoietic_system_phenotyp	0.60899132

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Albinism (HP:0001022)	3.48873752
2	Intestinal atresia (HP:0011100)	3.36194193
3	Renal cortical cysts (HP:0000803)	3.34400385
4	Abnormality of the renal cortex (HP:0011035)	3.30989706
5	Abnormality of midbrain morphology (HP:0002418)	3.25942279
6	Molar tooth sign on MRI (HP:0002419)	3.25942279
7	Pancreatic fibrosis (HP:0100732)	3.11228721
8	Methylmalonic acidemia (HP:0002912)	2.89368553
9	Hypothermia (HP:0002045)	2.87960616
10	Pancreatic cysts (HP:0001737)	2.87484985
11	Medial flaring of the eyebrow (HP:0010747)	2.79498244
12	Nephronophthisis (HP:0000090)	2.72984355
13	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.72643240
14	Abnormality of the renal medulla (HP:0100957)	2.68991476
15	Progressive macrocephaly (HP:0004481)	2.66595876
16	Abnormality of methionine metabolism (HP:0010901)	2.64698212
17	True hermaphroditism (HP:0010459)	2.62340486
18	Hypoplasia of the fovea (HP:0007750)	2.53830782
19	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.53830782
20	Hyperventilation (HP:0002883)	2.53368479
21	Acute encephalopathy (HP:0006846)	2.48197331
22	Abnormality of chromosome stability (HP:0003220)	2.44600355
23	Chronic hepatic failure (HP:0100626)	2.40672975
24	Abnormality of macular pigmentation (HP:0008002)	2.37760144
25	Bifid tongue (HP:0010297)	2.33436228
26	Acute necrotizing encephalopathy (HP:0006965)	2.32165584
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.30474694
28	Increased CSF lactate (HP:0002490)	2.28781654
29	Hepatic necrosis (HP:0002605)	2.27053398
30	Abnormality of vitamin B metabolism (HP:0004340)	2.26710190
31	Congenital sensorineural hearing impairment (HP:0008527)	2.25669989
32	Patchy hypopigmentation of hair (HP:0011365)	2.22282223
33	Adrenal hypoplasia (HP:0000835)	2.21917685
34	Pancreatic islet-cell hyperplasia (HP:0004510)	2.21683495
35	Abnormality of the fovea (HP:0000493)	2.18126897
36	Hepatocellular necrosis (HP:0001404)	2.17088275
37	Long clavicles (HP:0000890)	2.15762751
38	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.15238916
39	Severe visual impairment (HP:0001141)	2.14588973
40	Postaxial foot polydactyly (HP:0001830)	2.14139167
41	Tubulointerstitial nephritis (HP:0001970)	2.12972382
42	Neoplasm of the small intestine (HP:0100833)	2.11082368
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.09841434
44	Volvulus (HP:0002580)	2.08266076
45	Colon cancer (HP:0003003)	2.07880029
46	Sensory axonal neuropathy (HP:0003390)	2.07458927
47	Acute myeloid leukemia (HP:0004808)	2.06675920
48	Large for gestational age (HP:0001520)	2.05677675
49	Methylmalonic aciduria (HP:0012120)	2.03858597
50	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.02810768
51	White forelock (HP:0002211)	2.01537110
52	Hypoglycemic coma (HP:0001325)	2.01105025
53	Rhabdomyosarcoma (HP:0002859)	2.01003045
54	Mitochondrial inheritance (HP:0001427)	2.00734050
55	Thyroiditis (HP:0100646)	2.00533908
56	Biliary tract neoplasm (HP:0100574)	2.00427502
57	Gaze-evoked nystagmus (HP:0000640)	1.99546340
58	Aqueductal stenosis (HP:0002410)	1.97755356
59	Central scotoma (HP:0000603)	1.97162319
60	Dyschromatopsia (HP:0007641)	1.96129453
61	Abnormal mitochondria in muscle tissue (HP:0008316)	1.95753106
62	Abnormal biliary tract morphology (HP:0012440)	1.95682482
63	Neoplasm of the adrenal cortex (HP:0100641)	1.91930638
64	Genital tract atresia (HP:0001827)	1.91785115
65	Hyperglycinemia (HP:0002154)	1.91667345
66	Congenital primary aphakia (HP:0007707)	1.91449683
67	Renal hypoplasia (HP:0000089)	1.91016974
68	Attenuation of retinal blood vessels (HP:0007843)	1.90588255
69	Type I transferrin isoform profile (HP:0003642)	1.90365182
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.89174399
71	Abnormal protein N-linked glycosylation (HP:0012347)	1.89174399
72	Abnormal protein glycosylation (HP:0012346)	1.89174399
73	Abnormal glycosylation (HP:0012345)	1.89174399
74	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88712732
75	Abnormality of alanine metabolism (HP:0010916)	1.88712732
76	Hyperalaninemia (HP:0003348)	1.88712732
77	Hemiparesis (HP:0001269)	1.86536835
78	Homocystinuria (HP:0002156)	1.86233201
79	Abnormality of homocysteine metabolism (HP:0010919)	1.86233201
80	Short tibia (HP:0005736)	1.85421370
81	Astigmatism (HP:0000483)	1.84317718
82	Cupped ear (HP:0000378)	1.81397495
83	Abnormality of serum amino acid levels (HP:0003112)	1.80357674
84	Cutaneous melanoma (HP:0012056)	1.79556952
85	Abnormality of the duodenum (HP:0002246)	1.77527267
86	Gait imbalance (HP:0002141)	1.75990993
87	Postaxial hand polydactyly (HP:0001162)	1.75607191
88	Abnormality of the ileum (HP:0001549)	1.75489686
89	Tubulointerstitial abnormality (HP:0001969)	1.72617630
90	Abnormal rod and cone electroretinograms (HP:0008323)	1.71910760
91	Nephrogenic diabetes insipidus (HP:0009806)	1.70587207
92	Progressive inability to walk (HP:0002505)	1.69963861
93	Ketoacidosis (HP:0001993)	1.69617550
94	Sloping forehead (HP:0000340)	1.69590979
95	Tented upper lip vermilion (HP:0010804)	1.69321135
96	Stomach cancer (HP:0012126)	1.69203809
97	Barrel-shaped chest (HP:0001552)	1.69159987
98	Meckel diverticulum (HP:0002245)	1.69117898
99	Oculomotor apraxia (HP:0000657)	1.68079872
100	Ectopic kidney (HP:0000086)	1.66498591

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.87669064
2	MAP4K2	3.57581340
3	TRIM28	3.57038897
4	EIF2AK3	2.83638237
5	NUAK1	2.81203912
6	BMPR1B	2.75441964
7	PDK2	2.63673579
8	ACVR1B	2.20545357
9	MST4	2.20395751
10	SIK3	2.10847576
11	TNIK	2.10267548
12	STK39	2.02968877
13	FGFR2	1.74254530
14	MUSK	1.69328714
15	BCR	1.69266549
16	STK3	1.68805773
17	GRK1	1.66574554
18	WNK3	1.65694003
19	EIF2AK1	1.54944752
20	INSRR	1.54409054
21	PTK2B	1.48207295
22	AKT3	1.46539736
23	OXSR1	1.44399309
24	PLK2	1.44084883
25	PAK3	1.41718557
26	ADRBK2	1.39214011
27	MAPK13	1.38288166
28	FER	1.29224481
29	FLT3	1.28307167
30	PLK3	1.27276272
31	BRSK2	1.25829616
32	STK38L	1.20996889
33	NLK	1.17693182
34	MKNK2	1.08475619
35	STK16	1.06415779
36	OBSCN	1.05274361
37	ERBB3	0.99781358
38	PNCK	0.98844591
39	TAOK3	0.94866396
40	MAP3K2	0.92764172
41	CSNK1G1	0.90696269
42	TGFBR1	0.90522155
43	TNK2	0.89769916
44	ZAK	0.88433118
45	PINK1	0.88381234
46	KSR1	0.86170789
47	PRKCE	0.83316247
48	PLK4	0.80090395
49	MKNK1	0.78864594
50	TEC	0.78531721
51	FGFR1	0.76434430
52	EIF2AK2	0.74123662
53	PBK	0.71082905
54	TAF1	0.70160287
55	NTRK3	0.68915081
56	ATR	0.68181437
57	KIT	0.66110184
58	EPHA4	0.65075466
59	ATM	0.63511437
60	CSNK1G3	0.62097558
61	STK24	0.61734168
62	WEE1	0.59246517
63	CSNK1A1L	0.59067044
64	WNK4	0.58025907
65	BCKDK	0.57903188
66	CSNK1G2	0.55932938
67	RPS6KB1	0.55868076
68	ERBB4	0.55681701
69	LATS1	0.54935199
70	FGR	0.54642316
71	CASK	0.53037796
72	VRK1	0.52174547
73	CCNB1	0.51717896
74	STK4	0.51664920
75	ADRBK1	0.48309160
76	MARK3	0.47237263
77	MELK	0.46079440
78	RAF1	0.42146974
79	ROCK1	0.38932658
80	PLK1	0.36842423
81	RIPK4	0.36764837
82	PRKG1	0.36091064
83	PIK3CG	0.33336268
84	PRKAA1	0.33144149
85	PRKACB	0.32850466
86	MAP2K1	0.30806136
87	MINK1	0.30503981
88	MET	0.30481073
89	PRKCI	0.29957268
90	BMPR2	0.29197312
91	CAMK2A	0.29121047
92	CSNK1D	0.29100578
93	SRPK1	0.28408987
94	MAP3K4	0.27974888
95	CAMK2D	0.27026078
96	YES1	0.26539755
97	CHEK2	0.26476695
98	FGFR3	0.26313367
99	MAPKAPK5	0.26261540
100	PRKCQ	0.26076090

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.81931591
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.19403264
3	Propanoate metabolism_Homo sapiens_hsa00640	3.06870341
4	Protein export_Homo sapiens_hsa03060	2.94664502
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.75894241
6	Butanoate metabolism_Homo sapiens_hsa00650	2.60709292
7	Homologous recombination_Homo sapiens_hsa03440	2.58526913
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.57255223
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.34071659
10	Mismatch repair_Homo sapiens_hsa03430	2.31464651
11	Basal transcription factors_Homo sapiens_hsa03022	2.24745688
12	Proteasome_Homo sapiens_hsa03050	2.10638554
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.99614977
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.91575137
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90040711
16	One carbon pool by folate_Homo sapiens_hsa00670	1.80971252
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74827873
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74772276
19	RNA degradation_Homo sapiens_hsa03018	1.71912792
20	Fatty acid elongation_Homo sapiens_hsa00062	1.54944173
21	RNA polymerase_Homo sapiens_hsa03020	1.54080162
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.51069494
23	Phototransduction_Homo sapiens_hsa04744	1.48609802
24	Fatty acid degradation_Homo sapiens_hsa00071	1.47958692
25	Peroxisome_Homo sapiens_hsa04146	1.47130841
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.44715762
27	Circadian rhythm_Homo sapiens_hsa04710	1.41986754
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.37638243
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.30375447
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.28231729
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.26696443
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22745827
33	Glutathione metabolism_Homo sapiens_hsa00480	1.22435224
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.20568899
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.19460692
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.17483073
37	Olfactory transduction_Homo sapiens_hsa04740	1.13824683
38	Regulation of autophagy_Homo sapiens_hsa04140	1.13402956
39	DNA replication_Homo sapiens_hsa03030	1.13288376
40	Purine metabolism_Homo sapiens_hsa00230	1.13217251
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12126947
42	Caffeine metabolism_Homo sapiens_hsa00232	1.09406903
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08418005
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.07542019
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06149112
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.06127380
47	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.01128027
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99057462
49	ABC transporters_Homo sapiens_hsa02010	0.94854495
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93984044
51	Oxidative phosphorylation_Homo sapiens_hsa00190	0.93608305
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.91963010
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91811545
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90875994
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.90716761
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86921544
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86742192
58	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.84579681
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82671045
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.81564646
61	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.80193623
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.79512756
63	Base excision repair_Homo sapiens_hsa03410	0.76130542
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75712562
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.75115069
66	RNA transport_Homo sapiens_hsa03013	0.72784688
67	Metabolic pathways_Homo sapiens_hsa01100	0.72393397
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72054636
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71358976
70	Parkinsons disease_Homo sapiens_hsa05012	0.68849084
71	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.68085821
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67865423
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65198968
74	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.63596366
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.58522981
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.55423637
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53306377
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52860063
79	Lysine degradation_Homo sapiens_hsa00310	0.52826634
80	Carbon metabolism_Homo sapiens_hsa01200	0.52743544
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52088838
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48277400
83	Oocyte meiosis_Homo sapiens_hsa04114	0.48125009
84	Folate biosynthesis_Homo sapiens_hsa00790	0.47895175
85	Taste transduction_Homo sapiens_hsa04742	0.47803445
86	p53 signaling pathway_Homo sapiens_hsa04115	0.44316066
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43936810
88	Huntingtons disease_Homo sapiens_hsa05016	0.38270365
89	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.36680552
90	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35483654
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30061693
92	Cell cycle_Homo sapiens_hsa04110	0.29598134
93	Retinol metabolism_Homo sapiens_hsa00830	0.29310074
94	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.26019819
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.25212125
96	Serotonergic synapse_Homo sapiens_hsa04726	0.24477884
97	Mineral absorption_Homo sapiens_hsa04978	0.22792327
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.22487979
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.22437453
100	Melanoma_Homo sapiens_hsa05218	0.22046616

RIMKLBP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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