RIMS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.37636745
2vocalization behavior (GO:0071625)5.89281788
3locomotory exploration behavior (GO:0035641)5.74673298
4synaptic vesicle maturation (GO:0016188)5.73843492
5* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.60122682
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.53296659
7* synaptic vesicle exocytosis (GO:0016079)5.53142941
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.49943719
9* glutamate secretion (GO:0014047)5.29428911
10neuronal action potential propagation (GO:0019227)5.23324898
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.16941115
12regulation of synaptic vesicle exocytosis (GO:2000300)5.16605242
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.06055274
14regulation of glutamate receptor signaling pathway (GO:1900449)5.05346497
15protein localization to synapse (GO:0035418)5.03768161
16neuron cell-cell adhesion (GO:0007158)4.93379058
17glutamate receptor signaling pathway (GO:0007215)4.63811076
18regulation of synaptic vesicle transport (GO:1902803)4.63381799
19* neurotransmitter secretion (GO:0007269)4.61942807
20synaptic transmission, glutamatergic (GO:0035249)4.61509874
21exploration behavior (GO:0035640)4.56837524
22neuron-neuron synaptic transmission (GO:0007270)4.42590075
23gamma-aminobutyric acid transport (GO:0015812)4.39319528
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.36836699
25* regulation of neuronal synaptic plasticity (GO:0048168)4.25930633
26layer formation in cerebral cortex (GO:0021819)4.25109520
27neurotransmitter-gated ion channel clustering (GO:0072578)4.24931438
28* regulation of long-term neuronal synaptic plasticity (GO:0048169)4.24720112
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.13628453
30dendritic spine morphogenesis (GO:0060997)4.04738024
31long-term memory (GO:0007616)4.03964548
32regulation of synapse structural plasticity (GO:0051823)4.00035915
33* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.92526080
34positive regulation of synapse maturation (GO:0090129)3.91453839
35cellular potassium ion homeostasis (GO:0030007)3.87768824
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.86018113
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83474453
38neuronal ion channel clustering (GO:0045161)3.82083883
39cerebellar Purkinje cell differentiation (GO:0021702)3.79968057
40* regulation of postsynaptic membrane potential (GO:0060078)3.77329167
41* neurotransmitter transport (GO:0006836)3.76867470
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.75811178
43proline transport (GO:0015824)3.73232612
44synaptic vesicle endocytosis (GO:0048488)3.71064802
45* positive regulation of membrane potential (GO:0045838)3.70122716
46neuron recognition (GO:0008038)3.69717496
47L-amino acid import (GO:0043092)3.65579283
48transmission of nerve impulse (GO:0019226)3.61283613
49regulation of dendritic spine morphogenesis (GO:0061001)3.60588905
50long-term synaptic potentiation (GO:0060291)3.59457509
51* regulation of synaptic plasticity (GO:0048167)3.59425344
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.54798692
53axon ensheathment in central nervous system (GO:0032291)3.52176643
54central nervous system myelination (GO:0022010)3.52176643
55* regulation of neurotransmitter levels (GO:0001505)3.50805738
56cerebellar granule cell differentiation (GO:0021707)3.48821290
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48513787
58presynaptic membrane assembly (GO:0097105)3.47701562
59* regulation of neurotransmitter secretion (GO:0046928)3.46620565
60postsynaptic membrane organization (GO:0001941)3.44962715
61positive regulation of neurotransmitter secretion (GO:0001956)3.40539346
62* regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37362630
63sodium ion export (GO:0071436)3.36778668
64activation of protein kinase A activity (GO:0034199)3.36756818
65regulation of vesicle fusion (GO:0031338)3.36549133
66response to histamine (GO:0034776)3.35707392
67axonal fasciculation (GO:0007413)3.35531338
68amino acid import (GO:0043090)3.32969921
69neuromuscular process controlling balance (GO:0050885)3.30446343
70neuromuscular process controlling posture (GO:0050884)3.30243840
71* membrane depolarization (GO:0051899)3.29312909
72presynaptic membrane organization (GO:0097090)3.29090551
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.25367721
74positive regulation of neurotransmitter transport (GO:0051590)3.25235390
75mechanosensory behavior (GO:0007638)3.25015175
76membrane depolarization during action potential (GO:0086010)3.24387235
77potassium ion homeostasis (GO:0055075)3.23414546
78* regulation of neurotransmitter transport (GO:0051588)3.21075041
79auditory behavior (GO:0031223)3.18842193
80potassium ion import (GO:0010107)3.17606325
81regulation of synapse maturation (GO:0090128)3.15883758
82learning (GO:0007612)3.15830589
83positive regulation of dendritic spine morphogenesis (GO:0061003)3.15319330
84regulation of dendritic spine development (GO:0060998)3.15218566
85social behavior (GO:0035176)3.14382756
86intraspecies interaction between organisms (GO:0051703)3.14382756
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14140856
88synapse assembly (GO:0007416)3.13917572
89* synaptic transmission (GO:0007268)3.13595474
90serotonin metabolic process (GO:0042428)3.12011437
91prepulse inhibition (GO:0060134)3.11898236
92behavioral response to cocaine (GO:0048148)3.11313298
93response to auditory stimulus (GO:0010996)3.10967238
94cellular sodium ion homeostasis (GO:0006883)3.10098667
95dendrite morphogenesis (GO:0048813)3.09970485
96central nervous system projection neuron axonogenesis (GO:0021952)3.09914359
97* calcium ion-dependent exocytosis (GO:0017156)3.09195915
98startle response (GO:0001964)3.08994208
99innervation (GO:0060384)3.08843117
100positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08651123
101regulation of voltage-gated calcium channel activity (GO:1901385)3.08142699
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07874845
103positive regulation of synaptic transmission (GO:0050806)3.07097355
104primary amino compound metabolic process (GO:1901160)3.06180804
105behavioral defense response (GO:0002209)3.06018886
106behavioral fear response (GO:0001662)3.06018886
107positive regulation of dendritic spine development (GO:0060999)3.05535916
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05340077
109* regulation of synaptic transmission (GO:0050804)3.05129567
110neuromuscular synaptic transmission (GO:0007274)3.04875663
111* membrane hyperpolarization (GO:0060081)3.03224083
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02423603
113C4-dicarboxylate transport (GO:0015740)3.01912959
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01631070
115long term synaptic depression (GO:0060292)3.00908808
116acidic amino acid transport (GO:0015800)2.99310930
117adult walking behavior (GO:0007628)2.99170968
118cell differentiation in hindbrain (GO:0021533)2.97286772
119neuromuscular process (GO:0050905)2.96722220
120dendritic spine organization (GO:0097061)2.91085490
121positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90633040
122cell communication by electrical coupling (GO:0010644)2.88717329
123establishment of mitochondrion localization (GO:0051654)2.86221641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34211690
2GBX2_23144817_ChIP-Seq_PC3_Human3.80753682
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14765452
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08213761
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07186572
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75165726
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73019354
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73019354
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60800227
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57075104
11DROSHA_22980978_ChIP-Seq_HELA_Human2.49012434
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48589282
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48407816
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.45812021
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45198889
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.43828408
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42922414
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.24812202
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.20131457
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17962347
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.17505176
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.16510618
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06792749
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00763926
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94376196
26TAF15_26573619_Chip-Seq_HEK293_Human1.93261039
27* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90980525
28AR_21572438_ChIP-Seq_LNCaP_Human1.89519683
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85377387
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81953281
31* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81898348
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77763207
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76618631
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.74451463
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64097618
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58833841
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.52543402
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.50666821
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49071464
40* P300_19829295_ChIP-Seq_ESCs_Human1.46797670
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45316769
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41878906
43ZNF274_21170338_ChIP-Seq_K562_Hela1.40526409
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37601644
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37226108
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.34799798
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.34759472
48AR_25329375_ChIP-Seq_VCAP_Human1.33175552
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.31296593
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30968340
51STAT3_23295773_ChIP-Seq_U87_Human1.30404561
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28765612
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.26602319
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24097001
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24081738
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24074385
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24051157
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23722537
59* RING1B_27294783_Chip-Seq_ESCs_Mouse1.22231178
60* AR_19668381_ChIP-Seq_PC3_Human1.21695682
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18109606
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17786567
63IGF1R_20145208_ChIP-Seq_DFB_Human1.17341821
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17318935
65* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17277748
66* TCF4_23295773_ChIP-Seq_U87_Human1.14752414
67RNF2_27304074_Chip-Seq_NSC_Mouse1.14599599
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13576055
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10425262
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09631860
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09191648
72FUS_26573619_Chip-Seq_HEK293_Human1.08030142
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.07733060
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07394004
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06982710
76TP53_16413492_ChIP-PET_HCT116_Human1.06767062
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05830061
78CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04578766
79* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03362050
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03141997
81* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03057939
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.02455202
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01908943
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01908943
85* RUNX2_22187159_ChIP-Seq_PCA_Human1.01731495
86* KDM2B_26808549_Chip-Seq_REH_Human1.00704838
87AHR_22903824_ChIP-Seq_MCF-7_Human1.00368522
88* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99404501
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99322625
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98205663
91* CBP_20019798_ChIP-Seq_JUKART_Human0.98033260
92* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98033260
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98021139
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.97397123
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97277520
96SOX9_26525672_Chip-Seq_HEART_Mouse0.97255097
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96506425
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.95254874
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94807223
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.94542492
101CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93827384
102* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92817729
103* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91671459
104ER_23166858_ChIP-Seq_MCF-7_Human0.90975187
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.90694645
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90283395
107* JUN_21703547_ChIP-Seq_K562_Human0.89396657
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89254285
109BCAT_22108803_ChIP-Seq_LS180_Human0.89055086
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89041485
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.88489894
112VDR_22108803_ChIP-Seq_LS180_Human0.88440389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity6.30181613
2MP0003880_abnormal_central_pattern5.02841835
3* MP0003635_abnormal_synaptic_transmissio4.31061767
4MP0004270_analgesia3.78352067
5MP0009046_muscle_twitch3.61931841
6MP0009745_abnormal_behavioral_response3.59492978
7MP0002063_abnormal_learning/memory/cond3.42017352
8MP0002064_seizures3.36942456
9MP0001968_abnormal_touch/_nociception3.15604664
10MP0002572_abnormal_emotion/affect_behav2.95492713
11MP0005423_abnormal_somatic_nervous2.81463697
12MP0002272_abnormal_nervous_system2.78503058
13MP0002734_abnormal_mechanical_nocicepti2.78012801
14MP0001486_abnormal_startle_reflex2.71505353
15MP0001501_abnormal_sleep_pattern2.44677570
16MP0002736_abnormal_nociception_after2.42815759
17MP0002735_abnormal_chemical_nociception2.38263329
18MP0002822_catalepsy2.32041440
19MP0001440_abnormal_grooming_behavior2.23623029
20MP0002067_abnormal_sensory_capabilities2.15305702
21MP0008569_lethality_at_weaning2.05274327
22MP0002733_abnormal_thermal_nociception2.05002286
23MP0001970_abnormal_pain_threshold2.00015917
24* MP0002184_abnormal_innervation1.84905453
25MP0005386_behavior/neurological_phenoty1.82803054
26MP0004924_abnormal_behavior1.82803054
27MP0000778_abnormal_nervous_system1.80198309
28MP0003329_amyloid_beta_deposits1.79929950
29* MP0002557_abnormal_social/conspecific_i1.77180740
30MP0001984_abnormal_olfaction1.77013939
31MP0009780_abnormal_chondrocyte_physiolo1.74171825
32MP0004811_abnormal_neuron_physiology1.70632451
33MP0006276_abnormal_autonomic_nervous1.67442998
34MP0003879_abnormal_hair_cell1.66383384
35MP0004858_abnormal_nervous_system1.58386528
36MP0005646_abnormal_pituitary_gland1.58118316
37MP0005410_abnormal_fertilization1.56478993
38MP0002909_abnormal_adrenal_gland1.54005798
39* MP0000955_abnormal_spinal_cord1.47686210
40MP0002066_abnormal_motor_capabilities/c1.47531314
41* MP0002882_abnormal_neuron_morphology1.43087434
42MP0003787_abnormal_imprinting1.39605280
43MP0004885_abnormal_endolymph1.38935960
44MP0001905_abnormal_dopamine_level1.36390984
45MP0001502_abnormal_circadian_rhythm1.34852019
46MP0004142_abnormal_muscle_tone1.34328638
47MP0003633_abnormal_nervous_system1.31978684
48MP0001529_abnormal_vocalization1.31717772
49MP0001188_hyperpigmentation1.18667691
50MP0003631_nervous_system_phenotype1.18565722
51MP0003123_paternal_imprinting1.18486709
52MP0004145_abnormal_muscle_electrophysio1.18133155
53MP0005645_abnormal_hypothalamus_physiol1.12843494
54MP0005551_abnormal_eye_electrophysiolog1.12629416
55* MP0002152_abnormal_brain_morphology1.11013417
56MP0008872_abnormal_physiological_respon1.10419763
57MP0000569_abnormal_digit_pigmentation1.10148770
58MP0004742_abnormal_vestibular_system1.09688914
59MP0008877_abnormal_DNA_methylation1.07267559
60MP0010386_abnormal_urinary_bladder1.04094375
61MP0002229_neurodegeneration1.02750914
62MP0003122_maternal_imprinting0.98357940
63MP0001348_abnormal_lacrimal_gland0.98278842
64MP0003632_abnormal_nervous_system0.94907859
65MP0000751_myopathy0.94390728
66MP0008874_decreased_physiological_sensi0.92882492
67MP0001177_atelectasis0.92396478
68MP0002069_abnormal_eating/drinking_beha0.91516569
69MP0001963_abnormal_hearing_physiology0.89667507
70MP0003121_genomic_imprinting0.87903958
71MP0003698_abnormal_male_reproductive0.86785872
72MP0001986_abnormal_taste_sensitivity0.86719381
73MP0004085_abnormal_heartbeat0.81844371
74MP0005253_abnormal_eye_physiology0.80548551
75MP0005499_abnormal_olfactory_system0.80444574
76MP0005394_taste/olfaction_phenotype0.80444574
77MP0002837_dystrophic_cardiac_calcinosis0.79510975
78MP0005535_abnormal_body_temperature0.79334974
79* MP0002752_abnormal_somatic_nervous0.77812286
80MP0000920_abnormal_myelination0.75440869
81MP0001299_abnormal_eye_distance/0.74640707
82MP0003634_abnormal_glial_cell0.74508862
83MP0004215_abnormal_myocardial_fiber0.74288127
84MP0000013_abnormal_adipose_tissue0.74247136
85MP0000631_abnormal_neuroendocrine_gland0.73961972
86MP0000604_amyloidosis0.73343721
87MP0004147_increased_porphyrin_level0.72058155
88MP0003690_abnormal_glial_cell0.71280091
89MP0004484_altered_response_of0.71102689
90MP0001485_abnormal_pinna_reflex0.69659779
91MP0002638_abnormal_pupillary_reflex0.68949570
92MP0002090_abnormal_vision0.67974459
93MP0008961_abnormal_basal_metabolism0.64396673
94MP0003075_altered_response_to0.64345756
95MP0003137_abnormal_impulse_conducting0.63555448
96MP0000579_abnormal_nail_morphology0.63125698
97MP0001664_abnormal_digestion0.62432027
98MP0003938_abnormal_ear_development0.61309001
99MP0005623_abnormal_meninges_morphology0.60975972
100MP0004510_myositis0.60837590
101MP0002876_abnormal_thyroid_physiology0.60635718
102MP0004133_heterotaxia0.59936102
103MP0004130_abnormal_muscle_cell0.59500086
104MP0004233_abnormal_muscle_weight0.59255770
105MP0005409_darkened_coat_color0.58407272
106MP0005187_abnormal_penis_morphology0.56410841
107MP0003861_abnormal_nervous_system0.55619142
108MP0001943_abnormal_respiration0.55419684
109MP0001346_abnormal_lacrimal_gland0.53727595
110* MP0010769_abnormal_survival0.53461523
111MP0005670_abnormal_white_adipose0.53057285
112MP0002234_abnormal_pharynx_morphology0.52570298
113* MP0010770_preweaning_lethality0.52095106
114* MP0002082_postnatal_lethality0.52095106
115MP0003646_muscle_fatigue0.51755446
116MP0004043_abnormal_pH_regulation0.51713140
117* MP0010768_mortality/aging0.50462690
118MP0003956_abnormal_body_size0.49937797
119MP0000026_abnormal_inner_ear0.49802263

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.44285212
2Myokymia (HP:0002411)6.74399670
3Focal seizures (HP:0007359)6.15642510
4Visual hallucinations (HP:0002367)5.53399738
5Atonic seizures (HP:0010819)5.39399301
6Epileptic encephalopathy (HP:0200134)5.30047252
7Febrile seizures (HP:0002373)5.15241480
8Progressive cerebellar ataxia (HP:0002073)4.84201122
9Absence seizures (HP:0002121)4.55674446
10Action tremor (HP:0002345)4.16162251
11Dialeptic seizures (HP:0011146)4.13403387
12Generalized tonic-clonic seizures (HP:0002069)4.13351926
13Broad-based gait (HP:0002136)4.05643182
14Gaze-evoked nystagmus (HP:0000640)4.05636378
15Hyperventilation (HP:0002883)3.77381247
16Poor eye contact (HP:0000817)3.57120754
17Dysdiadochokinesis (HP:0002075)3.46865294
18Dysmetria (HP:0001310)3.23361510
19Supranuclear gaze palsy (HP:0000605)3.22080016
20Impaired social interactions (HP:0000735)3.20602499
21Abnormal social behavior (HP:0012433)3.20602499
22Impaired vibration sensation in the lower limbs (HP:0002166)3.20366461
23Truncal ataxia (HP:0002078)3.19065157
24Ankle clonus (HP:0011448)3.14721715
25Urinary bladder sphincter dysfunction (HP:0002839)3.11368610
26Amblyopia (HP:0000646)3.04708868
27Depression (HP:0000716)3.03945893
28Genetic anticipation (HP:0003743)3.01834976
29Impaired smooth pursuit (HP:0007772)2.99490424
30Mutism (HP:0002300)2.94845477
31Abnormal eating behavior (HP:0100738)2.90492251
32Anxiety (HP:0000739)2.90205061
33Scanning speech (HP:0002168)2.89953053
34Progressive inability to walk (HP:0002505)2.80474654
35Excessive salivation (HP:0003781)2.79969556
36Drooling (HP:0002307)2.79969556
37Postural instability (HP:0002172)2.78700459
38Papilledema (HP:0001085)2.75670052
39Hemiparesis (HP:0001269)2.73866108
40Dysmetric saccades (HP:0000641)2.71344244
41Abnormality of binocular vision (HP:0011514)2.69965985
42Diplopia (HP:0000651)2.69965985
43Fetal akinesia sequence (HP:0001989)2.64724037
44Limb dystonia (HP:0002451)2.63753635
45Abnormality of ocular smooth pursuit (HP:0000617)2.62386751
46Absent speech (HP:0001344)2.61729348
47Abnormality of the lower motor neuron (HP:0002366)2.61516101
48Hemiplegia (HP:0002301)2.59162274
49Epileptiform EEG discharges (HP:0011182)2.57249817
50Urinary urgency (HP:0000012)2.55992931
51Intention tremor (HP:0002080)2.53795196
52Status epilepticus (HP:0002133)2.53164952
53Spastic gait (HP:0002064)2.52557928
54Degeneration of the lateral corticospinal tracts (HP:0002314)2.48345168
55Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.48345168
56Stereotypic behavior (HP:0000733)2.46799795
57Cerebral inclusion bodies (HP:0100314)2.45000179
58EEG with generalized epileptiform discharges (HP:0011198)2.43646085
59Neurofibrillary tangles (HP:0002185)2.39757967
60Bradykinesia (HP:0002067)2.38748880
61Inability to walk (HP:0002540)2.38038341
62Torticollis (HP:0000473)2.35807020
63Insidious onset (HP:0003587)2.34128617
64Termporal pattern (HP:0011008)2.34128617
65Abnormality of the corticospinal tract (HP:0002492)2.30920637
66Generalized myoclonic seizures (HP:0002123)2.29723407
67Impaired vibratory sensation (HP:0002495)2.28932825
68Hypsarrhythmia (HP:0002521)2.27635429
69Focal dystonia (HP:0004373)2.25497532
70Akinesia (HP:0002304)2.24453759
71Morphological abnormality of the pyramidal tract (HP:0002062)2.22658803
72Pheochromocytoma (HP:0002666)2.18149000
73Spastic tetraplegia (HP:0002510)2.14200520
74Spastic tetraparesis (HP:0001285)2.12816456
75Ventricular fibrillation (HP:0001663)2.10818288
76Gait ataxia (HP:0002066)2.10490266
77Polyphagia (HP:0002591)2.09555126
78Annular pancreas (HP:0001734)2.07582252
79Chronic hepatic failure (HP:0100626)2.01894573
80Protruding tongue (HP:0010808)2.01233238
81Lower limb muscle weakness (HP:0007340)2.01144420
82Incomplete penetrance (HP:0003829)1.99720748
83Agitation (HP:0000713)1.96921293
84Amyotrophic lateral sclerosis (HP:0007354)1.96690641
85Megalencephaly (HP:0001355)1.93973393
86Cerebral hypomyelination (HP:0006808)1.93860690
87Blue irides (HP:0000635)1.93335019
88Craniofacial dystonia (HP:0012179)1.92381634
89Tetraplegia (HP:0002445)1.92236914
90Gait imbalance (HP:0002141)1.90343788
91Abnormality of salivation (HP:0100755)1.88781834
92Obstructive sleep apnea (HP:0002870)1.87734161
93Neuroendocrine neoplasm (HP:0100634)1.87541603
94Inappropriate behavior (HP:0000719)1.86169800
95Abnormality of saccadic eye movements (HP:0000570)1.85916171
96Paraplegia (HP:0010550)1.85574715
97Neuronal loss in central nervous system (HP:0002529)1.85279672
98Specific learning disability (HP:0001328)1.84241997
99Delusions (HP:0000746)1.83180269
100Lower limb asymmetry (HP:0100559)1.81433505
101Sleep apnea (HP:0010535)1.81414037
102Pointed chin (HP:0000307)1.79442310
103Psychosis (HP:0000709)1.77678402
104Spastic paraplegia (HP:0001258)1.77341654
105Oligodactyly (hands) (HP:0001180)1.73305571
106Hepatoblastoma (HP:0002884)1.72112086
107Hypoplasia of the corpus callosum (HP:0002079)1.72050566
108Clonus (HP:0002169)1.71133238
109Rigidity (HP:0002063)1.69848703
110Horizontal nystagmus (HP:0000666)1.69693675
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65256807
112Postural tremor (HP:0002174)1.64402076
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.63717420
114Absent/shortened dynein arms (HP:0200106)1.63717420
115Limb ataxia (HP:0002070)1.63664591
116Prolonged QT interval (HP:0001657)1.62421302
117Generalized hypopigmentation of hair (HP:0011358)1.60460555
118Rapidly progressive (HP:0003678)1.60124468
119Peripheral hypomyelination (HP:0007182)1.59562454
120Intellectual disability, severe (HP:0010864)1.59144991
121Abnormality of the labia minora (HP:0012880)1.58766405
122Optic nerve hypoplasia (HP:0000609)1.56508373
123Increased circulating renin level (HP:0000848)1.56188455
124Nephronophthisis (HP:0000090)1.53642631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.22514443
2EPHA44.17575477
3MAP3K93.85496633
4MAP3K43.35876353
5MAP2K72.91329208
6MARK12.82465182
7DAPK22.73492789
8MINK12.55760430
9CASK2.32494535
10MAP3K122.25386279
11PAK62.25027756
12NTRK22.20268171
13MAP2K42.14321816
14KSR21.95456627
15RIPK41.93963916
16PNCK1.83319068
17PRKD31.80680154
18CAMKK11.75969557
19DAPK11.72434357
20NTRK11.68840718
21PLK21.57399118
22CDK191.56970510
23TNIK1.56968085
24KSR11.55842889
25CDK51.51547563
26MAPK131.47820861
27GRK51.45790836
28SIK21.43582585
29CAMKK21.37811448
30ARAF1.36757128
31STK381.34828748
32PRPF4B1.34130555
33PRKCG1.20091899
34STK391.19196390
35MAP3K131.17824541
36FES1.12164754
37CAMK2A1.07824503
38LATS21.03094667
39TYRO31.02981631
40WNK41.02589780
41FRK1.01455740
42CAMK10.98570978
43UHMK10.96746871
44BRSK10.96579927
45OXSR10.94420838
46CDK180.92146063
47SGK2230.91275668
48SGK4940.91275668
49STK110.91233131
50CDK150.90717872
51PKN10.89124809
52CAMK2B0.87802349
53BMPR20.87644681
54RAF10.85419384
55CDK140.84790828
56TAOK10.83979755
57SGK20.83079152
58MAP3K20.82217424
59PHKG20.80450189
60PHKG10.80450189
61CDK11A0.78863066
62RET0.76427606
63PTK2B0.74336573
64PLK40.74163869
65DYRK1A0.71808359
66CSNK1G20.71463567
67PRKCH0.70793952
68SGK10.70444401
69PINK10.70304182
70PAK30.66824038
71MAP3K60.66123745
72CCNB10.65960384
73CAMK1D0.64495766
74SGK30.63524765
75MARK20.63073563
76CAMK1G0.62891332
77STK38L0.62041440
78INSRR0.58404655
79TNK20.57303444
80PDK10.56787802
81DYRK20.55408085
82CAMK2D0.54587479
83FGR0.53945287
84PDPK10.52072889
85MAP4K20.51401278
86CAMK2G0.51107291
87WNK10.50985964
88PRKCE0.50922856
89CSNK1A1L0.48709980
90ALK0.48616575
91AKT30.48214171
92CAMK40.47981164
93CDC42BPA0.47894356
94RPS6KA30.47619820
95MAPKAPK50.47367337
96PRKCZ0.46267694
97NME10.45364921
98RIPK10.45114139
99MAP3K10.44968026
100MUSK0.44244701
101BRAF0.44024536
102NEK60.42887048
103BCR0.42019440
104LMTK20.41888814
105PRKG10.41759955
106ADRBK20.41624506
107FYN0.41126330
108MAPK100.40866627
109FGFR20.39836507
110* PRKACA0.39157111
111ROCK20.38967916
112DAPK30.38649934
113* GSK3B0.38497693
114CSNK1D0.38232429
115CSNK1G30.37352993
116MAP2K10.35818773
117MAPK80.35333319
118MAPK120.35293145
119PRKCA0.34938027
120WNK30.34491179
121* CSNK1E0.33530692
122MAP3K70.32023858
123DYRK1B0.31183581
124PRKCB0.30838846
125BMPR1B0.28685422

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.11428011
2* Synaptic vesicle cycle_Homo sapiens_hsa047213.33913996
3GABAergic synapse_Homo sapiens_hsa047272.82387193
4* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82169285
5Long-term potentiation_Homo sapiens_hsa047202.76472344
6Glutamatergic synapse_Homo sapiens_hsa047242.74835193
7Circadian entrainment_Homo sapiens_hsa047132.72630495
8Olfactory transduction_Homo sapiens_hsa047402.72090070
9Morphine addiction_Homo sapiens_hsa050322.59813134
10Amphetamine addiction_Homo sapiens_hsa050312.48792999
11Salivary secretion_Homo sapiens_hsa049702.23052889
12Dopaminergic synapse_Homo sapiens_hsa047282.19838332
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08092062
14Insulin secretion_Homo sapiens_hsa049112.00436745
15Taste transduction_Homo sapiens_hsa047421.98128793
16Cholinergic synapse_Homo sapiens_hsa047251.89937148
17Gastric acid secretion_Homo sapiens_hsa049711.89900612
18Long-term depression_Homo sapiens_hsa047301.85286152
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83903036
20Serotonergic synapse_Homo sapiens_hsa047261.78104205
21Oxytocin signaling pathway_Homo sapiens_hsa049211.68726816
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64834485
23Renin secretion_Homo sapiens_hsa049241.64511492
24Calcium signaling pathway_Homo sapiens_hsa040201.63261789
25Collecting duct acid secretion_Homo sapiens_hsa049661.60521483
26Cocaine addiction_Homo sapiens_hsa050301.58568521
27GnRH signaling pathway_Homo sapiens_hsa049121.47840691
28Fatty acid biosynthesis_Homo sapiens_hsa000611.35565042
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34965255
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30835971
31Gap junction_Homo sapiens_hsa045401.29259586
32cAMP signaling pathway_Homo sapiens_hsa040241.27672535
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27505630
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19314246
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16370188
36Estrogen signaling pathway_Homo sapiens_hsa049151.15679618
37Type II diabetes mellitus_Homo sapiens_hsa049301.15645275
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12133967
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10558927
40Cardiac muscle contraction_Homo sapiens_hsa042601.08133622
41Axon guidance_Homo sapiens_hsa043601.04897405
42Glioma_Homo sapiens_hsa052141.02856666
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02600418
44ErbB signaling pathway_Homo sapiens_hsa040121.01445091
45Phototransduction_Homo sapiens_hsa047441.00290121
46Melanogenesis_Homo sapiens_hsa049160.99050945
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94057401
48Vitamin B6 metabolism_Homo sapiens_hsa007500.93119913
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.92368827
50Vibrio cholerae infection_Homo sapiens_hsa051100.90704572
51Pancreatic secretion_Homo sapiens_hsa049720.90497688
52Oocyte meiosis_Homo sapiens_hsa041140.87737477
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84563136
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.82859586
55Dorso-ventral axis formation_Homo sapiens_hsa043200.78721726
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78197611
57Thyroid hormone synthesis_Homo sapiens_hsa049180.76751005
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75948450
59Choline metabolism in cancer_Homo sapiens_hsa052310.72854060
60Arginine biosynthesis_Homo sapiens_hsa002200.72416154
61Nitrogen metabolism_Homo sapiens_hsa009100.71766368
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71258620
63MAPK signaling pathway_Homo sapiens_hsa040100.70587488
64Dilated cardiomyopathy_Homo sapiens_hsa054140.69048057
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65383822
66Type I diabetes mellitus_Homo sapiens_hsa049400.60505213
67Circadian rhythm_Homo sapiens_hsa047100.59651985
68Butanoate metabolism_Homo sapiens_hsa006500.56089021
69Ras signaling pathway_Homo sapiens_hsa040140.55971243
70VEGF signaling pathway_Homo sapiens_hsa043700.55553878
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55353337
72Inositol phosphate metabolism_Homo sapiens_hsa005620.55299495
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54657777
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.53626658
75Alzheimers disease_Homo sapiens_hsa050100.52517749
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51354170
77Rap1 signaling pathway_Homo sapiens_hsa040150.51163769
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.50956910
79Glucagon signaling pathway_Homo sapiens_hsa049220.50831882
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50609227
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47939284
82Hedgehog signaling pathway_Homo sapiens_hsa043400.47000815
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46340975
84Alcoholism_Homo sapiens_hsa050340.46011446
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43040102
86African trypanosomiasis_Homo sapiens_hsa051430.42875975
87Ovarian steroidogenesis_Homo sapiens_hsa049130.42438801
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42189493
89Mineral absorption_Homo sapiens_hsa049780.41085829
90mTOR signaling pathway_Homo sapiens_hsa041500.40657940
91Bile secretion_Homo sapiens_hsa049760.40499410
92Wnt signaling pathway_Homo sapiens_hsa043100.40216951
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39739273
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39659559
95Endocytosis_Homo sapiens_hsa041440.38649116
96Tight junction_Homo sapiens_hsa045300.38314214
97Hippo signaling pathway_Homo sapiens_hsa043900.37021187
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36218111
99Renal cell carcinoma_Homo sapiens_hsa052110.35679314
100Folate biosynthesis_Homo sapiens_hsa007900.35633119
101Endometrial cancer_Homo sapiens_hsa052130.35146707
102Oxidative phosphorylation_Homo sapiens_hsa001900.32773677
103Regulation of autophagy_Homo sapiens_hsa041400.32594752
104Non-small cell lung cancer_Homo sapiens_hsa052230.31732918
105Arginine and proline metabolism_Homo sapiens_hsa003300.29693028
106Chemokine signaling pathway_Homo sapiens_hsa040620.29347224
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29288990
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28864353
109Insulin signaling pathway_Homo sapiens_hsa049100.28434474
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28138150
111beta-Alanine metabolism_Homo sapiens_hsa004100.28027507
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27568640
113Prion diseases_Homo sapiens_hsa050200.27549474
114Histidine metabolism_Homo sapiens_hsa003400.27159756
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24560491
116ABC transporters_Homo sapiens_hsa020100.21307568

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »