RIMS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.98095204
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11759670
3synaptic vesicle exocytosis (GO:0016079)5.09150307
4* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06983228
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.89925922
6regulation of synaptic vesicle exocytosis (GO:2000300)4.88480227
7vocalization behavior (GO:0071625)4.86585973
8behavioral response to nicotine (GO:0035095)4.81636617
9synaptic vesicle maturation (GO:0016188)4.77339216
10locomotory exploration behavior (GO:0035641)4.71672483
11glutamate secretion (GO:0014047)4.68839032
12protein localization to synapse (GO:0035418)4.60342387
13* regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.55689909
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50631856
15neuron cell-cell adhesion (GO:0007158)4.44737151
16synaptic transmission, glutamatergic (GO:0035249)4.31065766
17regulation of synaptic vesicle transport (GO:1902803)4.26955634
18neuron-neuron synaptic transmission (GO:0007270)4.26782855
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.25312088
20neurotransmitter-gated ion channel clustering (GO:0072578)4.19883230
21regulation of glutamate receptor signaling pathway (GO:1900449)4.18032740
22glutamate receptor signaling pathway (GO:0007215)4.15138730
23neuronal action potential propagation (GO:0019227)4.13266869
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11440866
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.03243781
26* neurotransmitter secretion (GO:0007269)3.99332302
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97870765
28presynaptic membrane assembly (GO:0097105)3.93562841
29cellular potassium ion homeostasis (GO:0030007)3.87002746
30positive regulation of synapse maturation (GO:0090129)3.84504431
31cerebellar Purkinje cell differentiation (GO:0021702)3.81422846
32retinal cone cell development (GO:0046549)3.79305678
33presynaptic membrane organization (GO:0097090)3.76851722
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.74954691
35response to pheromone (GO:0019236)3.74294527
36response to histamine (GO:0034776)3.69385828
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62339946
38rhodopsin mediated signaling pathway (GO:0016056)3.62123308
39regulation of rhodopsin mediated signaling pathway (GO:0022400)3.62037769
40cerebellar granule cell differentiation (GO:0021707)3.61193594
41regulation of neuronal synaptic plasticity (GO:0048168)3.60985688
42long-term memory (GO:0007616)3.57030547
43synaptic vesicle endocytosis (GO:0048488)3.56513110
44striatum development (GO:0021756)3.56438504
45* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55538177
46* regulation of postsynaptic membrane potential (GO:0060078)3.53997115
47detection of light stimulus involved in sensory perception (GO:0050962)3.53788637
48detection of light stimulus involved in visual perception (GO:0050908)3.53788637
49* membrane hyperpolarization (GO:0060081)3.47526931
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.46893949
51innervation (GO:0060384)3.45726086
52exploration behavior (GO:0035640)3.45179099
53regulation of neurotransmitter secretion (GO:0046928)3.44924091
54gamma-aminobutyric acid transport (GO:0015812)3.44471168
55long-term synaptic potentiation (GO:0060291)3.43497994
56* neurotransmitter transport (GO:0006836)3.43154970
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.43075179
58pyrimidine nucleobase catabolic process (GO:0006208)3.42905620
59* positive regulation of membrane potential (GO:0045838)3.41892955
60regulation of voltage-gated calcium channel activity (GO:1901385)3.41331538
61prepulse inhibition (GO:0060134)3.40926211
62membrane depolarization during action potential (GO:0086010)3.38113023
63behavioral response to cocaine (GO:0048148)3.35655183
64regulation of synapse structural plasticity (GO:0051823)3.35409316
65neuronal action potential (GO:0019228)3.31910750
66retinal rod cell development (GO:0046548)3.31583081
67positive regulation of neurotransmitter transport (GO:0051590)3.31036646
68negative regulation of cytosolic calcium ion concentration (GO:0051481)3.29199163
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29168342
70postsynaptic membrane organization (GO:0001941)3.26803655
71dopamine transport (GO:0015872)3.26330493
72transmission of nerve impulse (GO:0019226)3.26062952
73regulation of neurotransmitter transport (GO:0051588)3.25096296
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24635106
75nucleobase catabolic process (GO:0046113)3.24218457
76dendritic spine morphogenesis (GO:0060997)3.20588438
77layer formation in cerebral cortex (GO:0021819)3.18498223
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.18032239
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17569033
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15398663
81cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14445644
82neuromuscular synaptic transmission (GO:0007274)3.13277768
83synapse assembly (GO:0007416)3.13262737
84regulation of synaptic plasticity (GO:0048167)3.11247564
85protein polyglutamylation (GO:0018095)3.10603174
86sodium ion export (GO:0071436)3.09385249
87proline transport (GO:0015824)3.08669756
88behavioral defense response (GO:0002209)3.07537619
89behavioral fear response (GO:0001662)3.07537619
90* membrane depolarization (GO:0051899)3.07518132
91regulation of vesicle fusion (GO:0031338)3.05320214
92neuromuscular process controlling posture (GO:0050884)3.04895965
93photoreceptor cell development (GO:0042461)3.03425472
94regulation of synapse maturation (GO:0090128)3.03214114
95serotonin metabolic process (GO:0042428)3.02172145
96neuron recognition (GO:0008038)3.01511449
97startle response (GO:0001964)3.00967250
98neurofilament cytoskeleton organization (GO:0060052)3.00924863
99response to auditory stimulus (GO:0010996)3.00286871
100positive regulation of neurotransmitter secretion (GO:0001956)3.00171019
101auditory behavior (GO:0031223)2.98832068
102mating behavior (GO:0007617)2.98183208
103behavioral response to ethanol (GO:0048149)2.97854984
104eye photoreceptor cell development (GO:0042462)2.96233344
105catecholamine transport (GO:0051937)2.96139273
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95233002
107regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.94390529
108regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.94390529
109synaptic transmission (GO:0007268)2.94380958
110positive regulation of synaptic transmission (GO:0050806)2.93853624
111* regulation of neurotransmitter levels (GO:0001505)2.92923583
112primary amino compound metabolic process (GO:1901160)2.89500569
113mechanosensory behavior (GO:0007638)2.85612523
114adult walking behavior (GO:0007628)2.79807013
115protein localization to cilium (GO:0061512)2.78831221
116action potential (GO:0001508)2.78638407
117L-fucose catabolic process (GO:0042355)2.77539887
118fucose catabolic process (GO:0019317)2.77539887
119L-fucose metabolic process (GO:0042354)2.77539887
120glycerophospholipid catabolic process (GO:0046475)2.76606106
121dopamine biosynthetic process (GO:0042416)2.75953733
122detection of calcium ion (GO:0005513)2.69339388
123central nervous system myelination (GO:0022010)2.68684305
124axon ensheathment in central nervous system (GO:0032291)2.68684305
125nonmotile primary cilium assembly (GO:0035058)2.67769876
126regulation of calcium ion-dependent exocytosis (GO:0017158)2.63476548
127axonal fasciculation (GO:0007413)2.62992184
128response to amphetamine (GO:0001975)2.62990440
129potassium ion transmembrane transport (GO:0071805)2.61823278
130cellular potassium ion transport (GO:0071804)2.61823278
131cellular ketone body metabolic process (GO:0046950)2.61079572
132negative regulation of dendrite development (GO:2000171)2.59557693
133atrial cardiac muscle cell action potential (GO:0086014)2.59425583
134synaptic transmission, cholinergic (GO:0007271)2.58300731
135reflex (GO:0060004)2.57394258
136adult behavior (GO:0030534)2.56129642
137water-soluble vitamin biosynthetic process (GO:0042364)2.55689472
138regulation of neurotransmitter uptake (GO:0051580)2.52689350
139regulation of action potential (GO:0098900)2.50680083
140negative regulation of translation, ncRNA-mediated (GO:0040033)2.49103527
141regulation of translation, ncRNA-mediated (GO:0045974)2.49103527
142negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49103527
143inositol phosphate catabolic process (GO:0071545)2.48932841
144positive regulation of meiosis (GO:0045836)2.47408586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.79967232
2* GBX2_23144817_ChIP-Seq_PC3_Human4.16659156
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82437269
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79381656
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.73099238
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66485008
7DROSHA_22980978_ChIP-Seq_HELA_Human2.48440026
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44274401
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38937665
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.37121398
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34568482
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29448464
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29448464
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28071320
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.26884763
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24617223
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21931844
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20742247
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.18276206
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07396297
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.06863892
22* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.06233776
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05772874
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04762802
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.04262714
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03080853
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.00111455
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97249868
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88947633
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.86772578
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85162906
32TAF15_26573619_Chip-Seq_HEK293_Human1.82692271
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80350016
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.71983287
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71862237
36AR_21572438_ChIP-Seq_LNCaP_Human1.70307217
37EWS_26573619_Chip-Seq_HEK293_Human1.69316732
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68317276
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63140698
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62935565
41* P300_19829295_ChIP-Seq_ESCs_Human1.55097969
42* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52068022
43* STAT3_23295773_ChIP-Seq_U87_Human1.50602893
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50488044
45IGF1R_20145208_ChIP-Seq_DFB_Human1.48480896
46* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48159772
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.45209370
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42469756
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.41328044
50* PIAS1_25552417_ChIP-Seq_VCAP_Human1.39349384
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39120440
52ZNF274_21170338_ChIP-Seq_K562_Hela1.38174271
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36626009
54TCF4_23295773_ChIP-Seq_U87_Human1.35379183
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.34159757
56* AR_19668381_ChIP-Seq_PC3_Human1.33464150
57FUS_26573619_Chip-Seq_HEK293_Human1.32323014
58* AR_25329375_ChIP-Seq_VCAP_Human1.32186513
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32047237
60* CBX2_27304074_Chip-Seq_ESCs_Mouse1.31289959
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30968874
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28188963
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27585920
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27430628
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25549018
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25420038
67* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25298002
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24203251
69* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24185414
70RNF2_27304074_Chip-Seq_NSC_Mouse1.23424910
71VDR_22108803_ChIP-Seq_LS180_Human1.22883573
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.22728602
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21682458
74* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21538429
75CBP_20019798_ChIP-Seq_JUKART_Human1.20568849
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20568849
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20448467
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19110792
79* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17820894
80TCF4_22108803_ChIP-Seq_LS180_Human1.16254348
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.15908373
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14301327
83TP53_22573176_ChIP-Seq_HFKS_Human1.14191220
84* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13265976
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12956759
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12818572
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12338622
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.12254366
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.11620221
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11001270
91RUNX2_22187159_ChIP-Seq_PCA_Human1.09947666
92* RING1B_27294783_Chip-Seq_ESCs_Mouse1.09617616
93* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09558917
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.09514958
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09346457
96AHR_22903824_ChIP-Seq_MCF-7_Human1.08400618
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08291564
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08291564
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.07246826
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06185562
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06085480
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05391483
103* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05385459
104P53_22387025_ChIP-Seq_ESCs_Mouse1.05337231
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05101221
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04836173
107* ER_23166858_ChIP-Seq_MCF-7_Human1.04409947
108SOX2_19829295_ChIP-Seq_ESCs_Human1.04222018
109NANOG_19829295_ChIP-Seq_ESCs_Human1.04222018
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03455254
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03398542
112* SMAD3_21741376_ChIP-Seq_ESCs_Human1.03095737
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.02829456
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02539200
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.01388733
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01013337
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00792778
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00714926
119TP53_16413492_ChIP-PET_HCT116_Human0.99972440
120BCAT_22108803_ChIP-Seq_LS180_Human0.99574879
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.99503887
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99055152
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98755123
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.94983537
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.94922183
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93717926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.93686803
2MP0003880_abnormal_central_pattern4.14613041
3MP0003635_abnormal_synaptic_transmissio3.64136467
4MP0004270_analgesia3.37320593
5MP0005551_abnormal_eye_electrophysiolog3.33230169
6MP0009046_muscle_twitch3.20935422
7MP0009745_abnormal_behavioral_response3.06184295
8MP0002063_abnormal_learning/memory/cond2.95848734
9MP0005423_abnormal_somatic_nervous2.94229687
10MP0002064_seizures2.91382030
11MP0002572_abnormal_emotion/affect_behav2.64042197
12MP0002272_abnormal_nervous_system2.63412890
13MP0001968_abnormal_touch/_nociception2.58860547
14MP0001486_abnormal_startle_reflex2.53487050
15MP0002734_abnormal_mechanical_nocicepti2.49655997
16MP0002822_catalepsy2.45360975
17MP0006072_abnormal_retinal_apoptosis2.32363119
18MP0001984_abnormal_olfaction2.13072393
19MP0005253_abnormal_eye_physiology2.09752997
20MP0002067_abnormal_sensory_capabilities2.04384086
21MP0002735_abnormal_chemical_nociception1.95039933
22MP0005646_abnormal_pituitary_gland1.92018849
23MP0001501_abnormal_sleep_pattern1.91452046
24MP0002909_abnormal_adrenal_gland1.85664810
25MP0001440_abnormal_grooming_behavior1.84734261
26MP0003787_abnormal_imprinting1.84095182
27MP0002736_abnormal_nociception_after1.83446300
28MP0008569_lethality_at_weaning1.83010075
29MP0009780_abnormal_chondrocyte_physiolo1.80713620
30MP0002184_abnormal_innervation1.78579453
31MP0001188_hyperpigmentation1.75999305
32MP0001970_abnormal_pain_threshold1.67805355
33MP0001502_abnormal_circadian_rhythm1.67114252
34MP0004924_abnormal_behavior1.64945489
35MP0005386_behavior/neurological_phenoty1.64945489
36MP0002733_abnormal_thermal_nociception1.64628928
37* MP0002557_abnormal_social/conspecific_i1.62814802
38MP0003879_abnormal_hair_cell1.62112365
39MP0000778_abnormal_nervous_system1.61322785
40MP0003195_calcinosis1.57512415
41MP0002882_abnormal_neuron_morphology1.56548882
42MP0002229_neurodegeneration1.56302180
43MP0004133_heterotaxia1.49277054
44MP0002638_abnormal_pupillary_reflex1.49079405
45MP0004811_abnormal_neuron_physiology1.48930448
46MP0004885_abnormal_endolymph1.47132727
47MP0002090_abnormal_vision1.45387232
48MP0002102_abnormal_ear_morphology1.45298807
49MP0001529_abnormal_vocalization1.44804929
50MP0005645_abnormal_hypothalamus_physiol1.42199983
51MP0010386_abnormal_urinary_bladder1.41432152
52MP0000955_abnormal_spinal_cord1.41019311
53MP0002066_abnormal_motor_capabilities/c1.30569814
54MP0004142_abnormal_muscle_tone1.28784852
55MP0003011_delayed_dark_adaptation1.27372436
56MP0003122_maternal_imprinting1.25199515
57MP0004145_abnormal_muscle_electrophysio1.23346779
58MP0000569_abnormal_digit_pigmentation1.22389435
59MP0003633_abnormal_nervous_system1.21923496
60MP0006276_abnormal_autonomic_nervous1.19327501
61MP0005195_abnormal_posterior_eye1.17844121
62MP0004858_abnormal_nervous_system1.17400686
63MP0004043_abnormal_pH_regulation1.16598948
64MP0002752_abnormal_somatic_nervous1.16255771
65MP0004742_abnormal_vestibular_system1.11972230
66MP0003329_amyloid_beta_deposits1.11118034
67MP0000631_abnormal_neuroendocrine_gland1.06974941
68MP0002152_abnormal_brain_morphology1.06634249
69MP0005394_taste/olfaction_phenotype1.06429696
70MP0005499_abnormal_olfactory_system1.06429696
71MP0004233_abnormal_muscle_weight1.02244318
72MP0003631_nervous_system_phenotype1.01159635
73MP0000013_abnormal_adipose_tissue1.00731284
74MP0003183_abnormal_peptide_metabolism0.99960025
75MP0005379_endocrine/exocrine_gland_phen0.99902476
76MP0006292_abnormal_olfactory_placode0.99387929
77MP0003283_abnormal_digestive_organ0.99280404
78MP0004147_increased_porphyrin_level0.96996584
79MP0002653_abnormal_ependyma_morphology0.96828447
80MP0003123_paternal_imprinting0.96246635
81MP0001986_abnormal_taste_sensitivity0.95239933
82MP0001963_abnormal_hearing_physiology0.93411507
83MP0001905_abnormal_dopamine_level0.92259655
84MP0000427_abnormal_hair_cycle0.91216586
85MP0002069_abnormal_eating/drinking_beha0.90160490
86MP0002938_white_spotting0.87703220
87MP0002928_abnormal_bile_duct0.87209856
88MP0003634_abnormal_glial_cell0.86322046
89MP0004215_abnormal_myocardial_fiber0.84780624
90MP0001324_abnormal_eye_pigmentation0.84653385
91MP0001485_abnormal_pinna_reflex0.84141018
92MP0003119_abnormal_digestive_system0.83701855
93MP0004085_abnormal_heartbeat0.83697820
94* MP0001944_abnormal_pancreas_morphology0.83380362
95MP0002234_abnormal_pharynx_morphology0.83317755
96MP0002163_abnormal_gland_morphology0.82323451
97MP0002160_abnormal_reproductive_system0.79572217
98MP0008872_abnormal_physiological_respon0.77438347
99MP0005391_vision/eye_phenotype0.76787998
100MP0005187_abnormal_penis_morphology0.75762399
101MP0000026_abnormal_inner_ear0.75644128
102MP0002751_abnormal_autonomic_nervous0.75008924
103MP0003632_abnormal_nervous_system0.74891580
104MP0003646_muscle_fatigue0.74297574
105MP0005174_abnormal_tail_pigmentation0.72271550
106MP0001177_atelectasis0.70381566
107MP0005389_reproductive_system_phenotype0.70356641
108MP0002837_dystrophic_cardiac_calcinosis0.69278977
109MP0003136_yellow_coat_color0.69246357
110* MP0002693_abnormal_pancreas_physiology0.68233073
111MP0008877_abnormal_DNA_methylation0.68099850
112MP0000678_abnormal_parathyroid_gland0.65105012
113MP0005535_abnormal_body_temperature0.63117576
114MP0002876_abnormal_thyroid_physiology0.62462734
115MP0003137_abnormal_impulse_conducting0.61587582
116MP0008874_decreased_physiological_sensi0.60576286
117MP0005409_darkened_coat_color0.60316113
118MP0003890_abnormal_embryonic-extraembry0.60185001
119MP0003121_genomic_imprinting0.58379342
120MP0001299_abnormal_eye_distance/0.58369754
121MP0000751_myopathy0.56899125
122MP0003698_abnormal_male_reproductive0.55702419

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.42072764
2Congenital stationary night blindness (HP:0007642)6.15594014
3Epileptic encephalopathy (HP:0200134)5.20252221
4Focal seizures (HP:0007359)4.65275175
5Febrile seizures (HP:0002373)4.59750262
6Myokymia (HP:0002411)4.45528740
7Limb dystonia (HP:0002451)4.30412949
8Central scotoma (HP:0000603)4.26461974
9Abnormality of macular pigmentation (HP:0008002)4.14635689
10Progressive cerebellar ataxia (HP:0002073)4.12854157
11Visual hallucinations (HP:0002367)4.12843846
12Bony spicule pigmentary retinopathy (HP:0007737)3.99891213
13Atonic seizures (HP:0010819)3.96251469
14Absence seizures (HP:0002121)3.79890580
15Gaze-evoked nystagmus (HP:0000640)3.69792723
16Abnormal rod and cone electroretinograms (HP:0008323)3.53908187
17Dialeptic seizures (HP:0011146)3.50790327
18Molar tooth sign on MRI (HP:0002419)3.48797940
19Abnormality of midbrain morphology (HP:0002418)3.48797940
20Severe visual impairment (HP:0001141)3.47556319
21Action tremor (HP:0002345)3.45708624
22Nephronophthisis (HP:0000090)3.25370186
23Dysdiadochokinesis (HP:0002075)3.23581623
24Scotoma (HP:0000575)3.19666722
25Hyperventilation (HP:0002883)3.18734469
26Pancreatic fibrosis (HP:0100732)3.17859412
27Generalized tonic-clonic seizures (HP:0002069)3.16801997
28Pancreatic cysts (HP:0001737)3.16378991
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.15558584
30Broad-based gait (HP:0002136)3.15490996
31Truncal ataxia (HP:0002078)3.07870221
32Amblyopia (HP:0000646)2.96285900
33Dyschromatopsia (HP:0007641)2.96206398
34Decreased central vision (HP:0007663)2.91089572
35Hypothermia (HP:0002045)2.89442446
36True hermaphroditism (HP:0010459)2.88458732
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.83760907
38Impaired smooth pursuit (HP:0007772)2.81938333
39Dysmetric saccades (HP:0000641)2.80289085
40Type II lissencephaly (HP:0007260)2.77929678
41Genetic anticipation (HP:0003743)2.77200164
42Epileptiform EEG discharges (HP:0011182)2.76689000
43Scanning speech (HP:0002168)2.76593374
44Gait imbalance (HP:0002141)2.71647408
45Impaired vibration sensation in the lower limbs (HP:0002166)2.68935093
46Urinary bladder sphincter dysfunction (HP:0002839)2.67768025
47Abnormality of the renal medulla (HP:0100957)2.67646425
48EEG with generalized epileptiform discharges (HP:0011198)2.65300266
49Depression (HP:0000716)2.64794170
50Ankle clonus (HP:0011448)2.61532351
51Poor eye contact (HP:0000817)2.61429949
52Attenuation of retinal blood vessels (HP:0007843)2.59358893
53Dysmetria (HP:0001310)2.57345184
54Abnormality of ocular smooth pursuit (HP:0000617)2.56194730
55Polydipsia (HP:0001959)2.53077130
56Abnormal drinking behavior (HP:0030082)2.53077130
57Congenital primary aphakia (HP:0007707)2.49577755
58Abnormality of the labia minora (HP:0012880)2.46237729
59Polyphagia (HP:0002591)2.45558253
60Postural instability (HP:0002172)2.45454107
61Hemiparesis (HP:0001269)2.43659898
62Drooling (HP:0002307)2.43442871
63Excessive salivation (HP:0003781)2.43442871
64Impaired social interactions (HP:0000735)2.41925988
65Abnormal social behavior (HP:0012433)2.41925988
66Inability to walk (HP:0002540)2.36444895
67Hypsarrhythmia (HP:0002521)2.36046706
68Medial flaring of the eyebrow (HP:0010747)2.35854539
69Abnormality of the renal cortex (HP:0011035)2.32700428
70Type II diabetes mellitus (HP:0005978)2.31103833
71Choroideremia (HP:0001139)2.29203669
72Nephrogenic diabetes insipidus (HP:0009806)2.27220744
73Abnormal eating behavior (HP:0100738)2.27073707
74Absent speech (HP:0001344)2.26278840
75Spastic gait (HP:0002064)2.26202955
76Intestinal atresia (HP:0011100)2.25181394
77Cystic liver disease (HP:0006706)2.24690113
78Supranuclear gaze palsy (HP:0000605)2.23840772
79Anxiety (HP:0000739)2.23643642
80Chronic hepatic failure (HP:0100626)2.20702958
81Lissencephaly (HP:0001339)2.17464177
82Pheochromocytoma (HP:0002666)2.08884917
83Intention tremor (HP:0002080)2.08837800
84Retinitis pigmentosa (HP:0000510)2.07094473
85Photophobia (HP:0000613)2.06309157
86Impaired vibratory sensation (HP:0002495)2.02028961
87Bradykinesia (HP:0002067)2.01770947
88Progressive inability to walk (HP:0002505)2.01465938
89Abnormality of the lower motor neuron (HP:0002366)2.00614727
90Oligodactyly (hands) (HP:0001180)1.99886332
91Decreased circulating renin level (HP:0003351)1.97225374
92Pachygyria (HP:0001302)1.97081780
93Specific learning disability (HP:0001328)1.95887624
94Pendular nystagmus (HP:0012043)1.93879805
95Poor coordination (HP:0002370)1.93448606
96Prolonged QT interval (HP:0001657)1.92955706
97Large for gestational age (HP:0001520)1.92641744
98Vaginal atresia (HP:0000148)1.92549671
99Genital tract atresia (HP:0001827)1.92470206
100Chorioretinal atrophy (HP:0000533)1.91929025
101Polyuria (HP:0000103)1.91779049
102Tubular atrophy (HP:0000092)1.91702761
103Abnormality of calcium-phosphate metabolism (HP:0100530)1.90636917
104Abnormality of the corticospinal tract (HP:0002492)1.90446040
105Agitation (HP:0000713)1.87964461
106Cerebellar dysplasia (HP:0007033)1.87003133
107Protruding tongue (HP:0010808)1.85495889
108Ketoacidosis (HP:0001993)1.84413092
109Retinal atrophy (HP:0001105)1.84194139
110Stereotypic behavior (HP:0000733)1.83465713
111Blue irides (HP:0000635)1.82941122
112Methylmalonic acidemia (HP:0002912)1.82910701
113Abolished electroretinogram (ERG) (HP:0000550)1.82787850
114Hemiplegia (HP:0002301)1.82431846
115Hypomagnesemia (HP:0002917)1.81612461
116Pigmentary retinal degeneration (HP:0001146)1.81262808
117Optic nerve hypoplasia (HP:0000609)1.81220285
118Sclerocornea (HP:0000647)1.81052922
119Status epilepticus (HP:0002133)1.80441246
120Neuroendocrine neoplasm (HP:0100634)1.77874988
121Gait ataxia (HP:0002066)1.76948478
122Abnormal EKG (HP:0003115)1.76619020
123Thyroid-stimulating hormone excess (HP:0002925)1.76076976
124Progressive macrocephaly (HP:0004481)1.75719950
125Lower limb muscle weakness (HP:0007340)1.75508315
126Retinal dysplasia (HP:0007973)1.75095799
127Horizontal nystagmus (HP:0000666)1.74481118
128Urinary urgency (HP:0000012)1.74428252
129Hyperinsulinemic hypoglycemia (HP:0000825)1.74299361
130Abnormality of saccadic eye movements (HP:0000570)1.73024051
131Absent/shortened dynein arms (HP:0200106)1.72867830
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.72867830
133Bile duct proliferation (HP:0001408)1.71895139
134Abnormal biliary tract physiology (HP:0012439)1.71895139
135Tachypnea (HP:0002789)1.71751895
136Keratoconus (HP:0000563)1.71631978
137Increased corneal curvature (HP:0100692)1.71631978
138Double outlet right ventricle (HP:0001719)1.71089764
139Congenital malformation of the right heart (HP:0011723)1.71089764
140Diplopia (HP:0000651)1.70920047
141Abnormality of binocular vision (HP:0011514)1.70920047
142Limb ataxia (HP:0002070)1.70699838
143Morphological abnormality of the pyramidal tract (HP:0002062)1.70455273
144Muscular hypotonia of the trunk (HP:0008936)1.68269091
145Acute necrotizing encephalopathy (HP:0006965)1.67755766
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66161787
147Spastic tetraplegia (HP:0002510)1.64749171
148Dyskinesia (HP:0100660)1.64177862
149Mitochondrial inheritance (HP:0001427)1.64094405
150Renal cortical cysts (HP:0000803)1.62794269
151Congenital sensorineural hearing impairment (HP:0008527)1.61905069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.18172620
2EPHA43.52351773
3CASK3.36058997
4MAP3K43.17886173
5MARK12.81666061
6MAP3K92.79822911
7MAP2K72.60931015
8DAPK22.46496675
9MINK12.31918808
10PAK62.15402396
11NTRK22.14017529
12BMPR1B2.00517166
13TNIK1.97525658
14ADRBK21.92586309
15MAP4K21.92502027
16PRPF4B1.90935086
17PRKD31.83338093
18INSRR1.66619043
19CAMKK11.64539263
20CAMKK21.64426422
21MAP2K41.59445180
22ZAK1.55485898
23NTRK11.54078778
24SIK21.51301632
25AKT31.50892850
26ACVR1B1.50721350
27KSR11.50209085
28DAPK11.45436895
29CDK191.45103393
30CAMK1D1.44099305
31MAPK131.41877392
32CDK51.41575520
33STK381.40791448
34PNCK1.40737798
35SGK4941.39379545
36SGK2231.39379545
37FGFR21.38404268
38SGK21.34079398
39DYRK21.33447760
40PLK21.25916998
41PRKCG1.22727045
42KSR21.22076105
43MKNK21.15516662
44CSNK1G11.14370115
45STK391.13281566
46TRIM281.12574169
47CSNK1G31.11204039
48WNK31.08173609
49UHMK11.07519325
50MAP3K121.06954893
51OXSR11.05301241
52TLK11.04804234
53FES1.04171545
54RIPK41.03814279
55CAMK2A1.02393806
56GRK51.01907736
57SGK30.99339592
58MAP3K20.96886810
59CCNB10.96438724
60WNK10.96286450
61PINK10.93446794
62DYRK1A0.92842236
63NUAK10.90656363
64GRK10.90120129
65CAMK1G0.85532635
66SGK10.84135211
67STK160.83507192
68CAMK10.83169138
69CDK180.83015225
70CAMK2B0.82841713
71BCR0.80710502
72CAMK2D0.80324719
73CDK150.78265312
74MAPKAPK50.77752538
75TYRO30.77616675
76SIK30.76961115
77STK110.76410851
78CDK30.76250010
79CDK140.76050760
80STK38L0.76019985
81PRKCH0.74425803
82PHKG20.74168916
83PHKG10.74168916
84CDC42BPA0.73892151
85PIK3CA0.72784613
86NEK60.68468114
87CDK11A0.67444452
88ARAF0.66791999
89CSNK1A1L0.66423545
90MARK20.66082397
91PAK30.62866675
92BMPR20.61250106
93PRKCE0.59090322
94FRK0.59026261
95CSNK1G20.57922993
96PKN10.56931068
97* RPS6KA30.56415620
98BRAF0.55406421
99RET0.55329374
100CSNK1E0.54295039
101NEK10.54095524
102CAMK40.53275731
103TNK20.52808872
104PRKCZ0.52489348
105MAPK100.52369265
106CSNK1A10.52214324
107PTK2B0.50366705
108CSNK1D0.49600845
109TIE10.48399549
110PRKCB0.48062424
111FER0.47214982
112PRKCI0.46515529
113PRKAA10.46440740
114CAMK2G0.45360528
115ERBB20.44971409
116PDK10.44744620
117ADRBK10.43955704
118PRKACA0.42587401
119ERBB30.42085318
120PDPK10.40793103
121WNK40.40471966
122MAP2K60.40285026
123PLK40.39976229
124PRKCA0.39535424
125HIPK20.39430051
126BRD40.39248251
127* PRKG10.38643111
128MAP3K60.37939528
129ALK0.37909074
130NME10.37598794
131MAP3K130.37275835
132GSK3B0.36994799
133RAF10.36910631
134TAOK30.35645432
135PLK30.35592199
136PRKACB0.33789814
137LIMK10.30673888

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.05005120
2Nicotine addiction_Homo sapiens_hsa050333.88797759
3Synaptic vesicle cycle_Homo sapiens_hsa047213.54044880
4GABAergic synapse_Homo sapiens_hsa047272.97687496
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84897146
6Circadian entrainment_Homo sapiens_hsa047132.76866156
7Morphine addiction_Homo sapiens_hsa050322.74129795
8Olfactory transduction_Homo sapiens_hsa047402.69476396
9Glutamatergic synapse_Homo sapiens_hsa047242.62618760
10Long-term potentiation_Homo sapiens_hsa047202.34517276
11* Insulin secretion_Homo sapiens_hsa049112.32898313
12Amphetamine addiction_Homo sapiens_hsa050312.31067695
13Dopaminergic synapse_Homo sapiens_hsa047282.15785303
14Salivary secretion_Homo sapiens_hsa049702.04815057
15Cholinergic synapse_Homo sapiens_hsa047251.94689925
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93265064
17Taste transduction_Homo sapiens_hsa047421.92576280
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90737407
19Butanoate metabolism_Homo sapiens_hsa006501.90066466
20Oxidative phosphorylation_Homo sapiens_hsa001901.90007223
21Serotonergic synapse_Homo sapiens_hsa047261.81139382
22Renin secretion_Homo sapiens_hsa049241.73123260
23Protein export_Homo sapiens_hsa030601.72592577
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72034226
25Collecting duct acid secretion_Homo sapiens_hsa049661.64085356
26Long-term depression_Homo sapiens_hsa047301.63398780
27Cocaine addiction_Homo sapiens_hsa050301.61841122
28Oxytocin signaling pathway_Homo sapiens_hsa049211.58996080
29Gastric acid secretion_Homo sapiens_hsa049711.52488545
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50020781
31Calcium signaling pathway_Homo sapiens_hsa040201.49889229
32Parkinsons disease_Homo sapiens_hsa050121.47354482
33Type II diabetes mellitus_Homo sapiens_hsa049301.44401858
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41330604
35Selenocompound metabolism_Homo sapiens_hsa004501.39188000
36Linoleic acid metabolism_Homo sapiens_hsa005911.33746200
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29208435
38cAMP signaling pathway_Homo sapiens_hsa040241.24241158
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22799307
40Tryptophan metabolism_Homo sapiens_hsa003801.22023996
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21860792
42Ether lipid metabolism_Homo sapiens_hsa005651.20128603
43GnRH signaling pathway_Homo sapiens_hsa049121.18578627
44Gap junction_Homo sapiens_hsa045401.17863818
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17649563
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16715225
47Vibrio cholerae infection_Homo sapiens_hsa051101.15418939
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14467118
49Circadian rhythm_Homo sapiens_hsa047101.14178518
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13774081
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10964011
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10765016
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09941573
54Alzheimers disease_Homo sapiens_hsa050101.09473372
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08051288
56Propanoate metabolism_Homo sapiens_hsa006401.07497918
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03510514
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.93863828
59Estrogen signaling pathway_Homo sapiens_hsa049150.93699687
60Cardiac muscle contraction_Homo sapiens_hsa042600.93075623
61Pancreatic secretion_Homo sapiens_hsa049720.91574257
62beta-Alanine metabolism_Homo sapiens_hsa004100.88595811
63Huntingtons disease_Homo sapiens_hsa050160.86604685
64Axon guidance_Homo sapiens_hsa043600.86372172
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85480257
66ErbB signaling pathway_Homo sapiens_hsa040120.83006338
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81388512
68Vitamin B6 metabolism_Homo sapiens_hsa007500.80133319
69ABC transporters_Homo sapiens_hsa020100.79200245
70Melanogenesis_Homo sapiens_hsa049160.78490467
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77905259
72Dilated cardiomyopathy_Homo sapiens_hsa054140.76240570
73Glioma_Homo sapiens_hsa052140.75211052
74Inositol phosphate metabolism_Homo sapiens_hsa005620.73564337
75Thyroid hormone synthesis_Homo sapiens_hsa049180.73254146
76RNA polymerase_Homo sapiens_hsa030200.71674885
77Caffeine metabolism_Homo sapiens_hsa002320.70836930
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.69980698
79Basal transcription factors_Homo sapiens_hsa030220.69465861
80Alcoholism_Homo sapiens_hsa050340.68503889
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67809386
82Oocyte meiosis_Homo sapiens_hsa041140.67620928
83Peroxisome_Homo sapiens_hsa041460.66706543
84Homologous recombination_Homo sapiens_hsa034400.66236048
85MAPK signaling pathway_Homo sapiens_hsa040100.65433067
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64162495
87Glucagon signaling pathway_Homo sapiens_hsa049220.64020099
88Dorso-ventral axis formation_Homo sapiens_hsa043200.61471701
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60735924
90Choline metabolism in cancer_Homo sapiens_hsa052310.58527120
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56607969
92RNA degradation_Homo sapiens_hsa030180.55810673
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55379603
94Mineral absorption_Homo sapiens_hsa049780.55193141
95Type I diabetes mellitus_Homo sapiens_hsa049400.54522557
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52992459
97Folate biosynthesis_Homo sapiens_hsa007900.51918075
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.51816664
99Histidine metabolism_Homo sapiens_hsa003400.51499031
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51222014
101mTOR signaling pathway_Homo sapiens_hsa041500.50762848
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49774455
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.48380773
104Ras signaling pathway_Homo sapiens_hsa040140.47858003
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46913781
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.46631235
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45660855
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44688009
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43255948
110Ovarian steroidogenesis_Homo sapiens_hsa049130.41153349
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40710184
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40201639
113Wnt signaling pathway_Homo sapiens_hsa043100.40108470
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39697849
115Retinol metabolism_Homo sapiens_hsa008300.38151192
116Fanconi anemia pathway_Homo sapiens_hsa034600.37898641
117Rap1 signaling pathway_Homo sapiens_hsa040150.36386970
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34870887
119Endometrial cancer_Homo sapiens_hsa052130.34399195
120Sulfur metabolism_Homo sapiens_hsa009200.34177206
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.33869962
122Metabolic pathways_Homo sapiens_hsa011000.33792750
123Fatty acid metabolism_Homo sapiens_hsa012120.32898908
124Purine metabolism_Homo sapiens_hsa002300.32629292
125Steroid biosynthesis_Homo sapiens_hsa001000.32176935
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31423895
127Endocytosis_Homo sapiens_hsa041440.31216899
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30746270
129Fructose and mannose metabolism_Homo sapiens_hsa000510.30465537
130Renal cell carcinoma_Homo sapiens_hsa052110.30039475
131Bile secretion_Homo sapiens_hsa049760.29708222
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.29473883
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.27112937
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25703259
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25583536
136Insulin signaling pathway_Homo sapiens_hsa049100.25332452
137VEGF signaling pathway_Homo sapiens_hsa043700.24446564
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.23540667
139Nitrogen metabolism_Homo sapiens_hsa009100.19619290
140Regulation of autophagy_Homo sapiens_hsa041400.19088664
141Non-small cell lung cancer_Homo sapiens_hsa052230.18879646
142Rheumatoid arthritis_Homo sapiens_hsa053230.18541819
143Chemokine signaling pathway_Homo sapiens_hsa040620.18118726

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