RIMS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.53958789
2synaptic vesicle maturation (GO:0016188)6.26853683
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.96656363
4locomotory exploration behavior (GO:0035641)5.64594068
5glutamate secretion (GO:0014047)5.38356607
6synaptic vesicle exocytosis (GO:0016079)5.36365916
7vocalization behavior (GO:0071625)5.35189307
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.21668506
9* regulation of synaptic vesicle exocytosis (GO:2000300)5.05767085
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.04329810
11neuronal action potential propagation (GO:0019227)4.93591880
12neurotransmitter secretion (GO:0007269)4.92967269
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.84645129
14L-amino acid import (GO:0043092)4.65343889
15gamma-aminobutyric acid transport (GO:0015812)4.60233961
16regulation of glutamate receptor signaling pathway (GO:1900449)4.55501813
17neuron cell-cell adhesion (GO:0007158)4.54886768
18* regulation of synaptic vesicle transport (GO:1902803)4.45109447
19layer formation in cerebral cortex (GO:0021819)4.31516839
20proline transport (GO:0015824)4.29162034
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.28148691
22cellular potassium ion homeostasis (GO:0030007)4.22237552
23exploration behavior (GO:0035640)4.21203807
24protein localization to synapse (GO:0035418)4.18721028
25amino acid import (GO:0043090)4.17266466
26cerebellar Purkinje cell differentiation (GO:0021702)4.15844257
27regulation of neuronal synaptic plasticity (GO:0048168)4.12364436
28neuromuscular process controlling posture (GO:0050884)4.04386129
29activation of protein kinase A activity (GO:0034199)4.01290886
30sodium ion export (GO:0071436)4.00416998
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99486391
32negative regulation of dendrite morphogenesis (GO:0050774)3.97899253
33synaptic transmission, glutamatergic (GO:0035249)3.96979598
34axon ensheathment in central nervous system (GO:0032291)3.93445162
35central nervous system myelination (GO:0022010)3.93445162
36positive regulation of dendritic spine development (GO:0060999)3.93033150
37* neurotransmitter transport (GO:0006836)3.92317073
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91389207
39positive regulation of dendritic spine morphogenesis (GO:0061003)3.90784780
40glutamate receptor signaling pathway (GO:0007215)3.80182264
41regulation of voltage-gated calcium channel activity (GO:1901385)3.79840511
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79459149
43positive regulation of neurotransmitter transport (GO:0051590)3.76465877
44response to pheromone (GO:0019236)3.73603818
45dendritic spine morphogenesis (GO:0060997)3.73208111
46regulation of synapse maturation (GO:0090128)3.73143860
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.70905883
48neuron-neuron synaptic transmission (GO:0007270)3.70182689
49regulation of neurotransmitter levels (GO:0001505)3.68823793
50long-term memory (GO:0007616)3.68776532
51regulation of synapse structural plasticity (GO:0051823)3.66347931
52positive regulation of neurotransmitter secretion (GO:0001956)3.66185389
53presynaptic membrane organization (GO:0097090)3.62369477
54positive regulation of membrane potential (GO:0045838)3.59798596
55synaptic vesicle endocytosis (GO:0048488)3.59108254
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56740670
57neuromuscular process controlling balance (GO:0050885)3.55232461
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54418804
59membrane depolarization during action potential (GO:0086010)3.53146833
60neurotransmitter-gated ion channel clustering (GO:0072578)3.52954488
61glycine transport (GO:0015816)3.51893376
62transmission of nerve impulse (GO:0019226)3.51304407
63regulation of dendritic spine morphogenesis (GO:0061001)3.50553935
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.48764368
65neuromuscular synaptic transmission (GO:0007274)3.48146324
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.47935561
67cellular sodium ion homeostasis (GO:0006883)3.45629396
68establishment of mitochondrion localization (GO:0051654)3.44587916
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.42252045
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41585111
71cell communication by electrical coupling (GO:0010644)3.40425489
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.39961618
73* regulation of neurotransmitter secretion (GO:0046928)3.38118173
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37380841
75vesicle transport along microtubule (GO:0047496)3.32405315
76presynaptic membrane assembly (GO:0097105)3.32047890
77regulation of postsynaptic membrane potential (GO:0060078)3.31460185
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31010691
79neuron recognition (GO:0008038)3.29636427
80auditory behavior (GO:0031223)3.28819150
81cerebellar granule cell differentiation (GO:0021707)3.27038140
82response to auditory stimulus (GO:0010996)3.25565875
83regulation of dendritic spine development (GO:0060998)3.21936276
84regulation of synaptic plasticity (GO:0048167)3.21674558
85cerebellar Purkinje cell layer development (GO:0021680)3.20477894
86positive regulation of synapse maturation (GO:0090129)3.19279565
87regulation of vesicle fusion (GO:0031338)3.19214966
88dendritic spine organization (GO:0097061)3.18832626
89dendrite morphogenesis (GO:0048813)3.18179209
90* regulation of synaptic transmission (GO:0050804)3.17254103
91postsynaptic membrane organization (GO:0001941)3.17022638
92membrane hyperpolarization (GO:0060081)3.16064067
93acidic amino acid transport (GO:0015800)3.15422921
94potassium ion import (GO:0010107)3.14496845
95regulation of synaptic transmission, glutamatergic (GO:0051966)3.13646666
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13480571
97axonal fasciculation (GO:0007413)3.12613022
98regulation of calcium ion-dependent exocytosis (GO:0017158)3.12090482
99negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11810606
100potassium ion homeostasis (GO:0055075)3.10866732
101membrane depolarization (GO:0051899)3.10329278
102* regulation of neurotransmitter transport (GO:0051588)3.10236434
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09337507
104regulation of ARF protein signal transduction (GO:0032012)3.09269331
105mating behavior (GO:0007617)3.09137160
106neuronal ion channel clustering (GO:0045161)3.08958244
107positive regulation of potassium ion transmembrane transport (GO:1901381)3.08867392
108establishment of synaptic vesicle localization (GO:0097480)3.07473408
109synaptic vesicle transport (GO:0048489)3.07473408
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05993000
111intraspecies interaction between organisms (GO:0051703)3.05989104
112social behavior (GO:0035176)3.05989104
113establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05061955
114mitochondrion transport along microtubule (GO:0047497)3.05061955
115cell differentiation in hindbrain (GO:0021533)3.03777042
116synapse assembly (GO:0007416)3.02522698
117axon cargo transport (GO:0008088)3.02317571
118prepulse inhibition (GO:0060134)3.02026943
119innervation (GO:0060384)3.01518746
120organelle transport along microtubule (GO:0072384)3.01336561
121neuromuscular process (GO:0050905)3.00104701
122long-term synaptic potentiation (GO:0060291)2.98347701
123synaptic transmission (GO:0007268)2.96368331
124cell migration in hindbrain (GO:0021535)2.95756788
125signal release (GO:0023061)2.94862496
126adult walking behavior (GO:0007628)2.90064857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08459412
2GBX2_23144817_ChIP-Seq_PC3_Human3.08970635
3* REST_21632747_ChIP-Seq_MESCs_Mouse3.04363843
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01394291
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97477952
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86294871
7DROSHA_22980978_ChIP-Seq_HELA_Human2.70471353
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63501430
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63501430
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.60163407
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57420176
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56624239
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51023576
14* REST_18959480_ChIP-ChIP_MESCs_Mouse2.50748205
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41434912
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40503025
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38551551
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37900884
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.33016433
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.32396421
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22211671
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.21691100
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20768364
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19679898
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18239546
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.14740896
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.12784740
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.05755980
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03481658
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93073231
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.72529730
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67248651
33SMAD4_21799915_ChIP-Seq_A2780_Human1.62718109
34ZNF274_21170338_ChIP-Seq_K562_Hela1.55768747
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53592200
36* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50837650
37TAF15_26573619_Chip-Seq_HEK293_Human1.43854765
38AR_21572438_ChIP-Seq_LNCaP_Human1.43396576
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38652059
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36954799
41SOX2_21211035_ChIP-Seq_LN229_Gbm1.36517520
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.34804756
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31917968
44AR_19668381_ChIP-Seq_PC3_Human1.29502109
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.27845857
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26780473
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26546391
48STAT3_23295773_ChIP-Seq_U87_Human1.26470697
49* KDM2B_26808549_Chip-Seq_K562_Human1.25072653
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23430012
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22685041
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20940419
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20644651
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.20391666
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19991886
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18276099
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16514804
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15573535
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13300385
60AR_25329375_ChIP-Seq_VCAP_Human1.12459454
61P300_19829295_ChIP-Seq_ESCs_Human1.11276084
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11205097
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10313782
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.09276978
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05908771
66IGF1R_20145208_ChIP-Seq_DFB_Human1.05905942
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05678804
68* TCF4_23295773_ChIP-Seq_U87_Human1.05357828
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.04853597
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04438673
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04349412
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04223105
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03529984
74SMAD3_21741376_ChIP-Seq_ESCs_Human1.03434739
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02884451
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02351381
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01834795
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00472770
79RNF2_27304074_Chip-Seq_NSC_Mouse1.00206565
80P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99786441
81* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99485413
82TET1_21490601_ChIP-Seq_MESCs_Mouse0.98827256
83PIAS1_25552417_ChIP-Seq_VCAP_Human0.98690887
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98187368
85CBX2_27304074_Chip-Seq_ESCs_Mouse0.97968401
86ARNT_22903824_ChIP-Seq_MCF-7_Human0.97884840
87AHR_22903824_ChIP-Seq_MCF-7_Human0.97040401
88KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95041679
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94913658
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94663606
91DPY_21335234_ChIP-Seq_ESCs_Mouse0.94593225
92TP53_20018659_ChIP-ChIP_R1E_Mouse0.94561402
93CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93442782
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92678666
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92329797
96OCT4_19829295_ChIP-Seq_ESCs_Human0.90855236
97RUNX2_22187159_ChIP-Seq_PCA_Human0.90713481
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.90203185
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89853207
100LXR_22292898_ChIP-Seq_THP-1_Human0.88808034
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88669546
102ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88302558
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86858952
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85611102
105* CTCF_27219007_Chip-Seq_Bcells_Human0.85308455
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83602326
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82706117
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82706117
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82447651
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82297033
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81188312
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81112596
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80319887
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80104477
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79712955
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78065977
117KLF4_19829295_ChIP-Seq_ESCs_Human0.77433702
118SMAD4_21741376_ChIP-Seq_EPCs_Human0.77396514
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77204419
120SMC4_20622854_ChIP-Seq_HELA_Human0.77121063
121SOX9_26525672_Chip-Seq_HEART_Mouse0.76934238
122* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75799178
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75266214
124CREB1_26743006_Chip-Seq_LNCaP_Human0.75171489
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74284542
126SMAD4_21741376_ChIP-Seq_ESCs_Human0.73491882
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72489802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.72980747
2MP0003880_abnormal_central_pattern4.32125181
3MP0003635_abnormal_synaptic_transmissio3.96874851
4MP0004270_analgesia3.67590236
5MP0009046_muscle_twitch3.45481858
6MP0001968_abnormal_touch/_nociception3.19779803
7MP0005423_abnormal_somatic_nervous3.18869585
8MP0009745_abnormal_behavioral_response3.17559522
9MP0002064_seizures3.06957999
10MP0002063_abnormal_learning/memory/cond2.99504512
11MP0002734_abnormal_mechanical_nocicepti2.86400996
12MP0002272_abnormal_nervous_system2.65649156
13MP0002572_abnormal_emotion/affect_behav2.61842206
14MP0002735_abnormal_chemical_nociception2.40866526
15MP0001501_abnormal_sleep_pattern2.35049400
16MP0002733_abnormal_thermal_nociception2.32434347
17MP0002736_abnormal_nociception_after2.28729905
18MP0001486_abnormal_startle_reflex2.27955223
19MP0009780_abnormal_chondrocyte_physiolo2.19677072
20MP0002909_abnormal_adrenal_gland2.16050190
21MP0001970_abnormal_pain_threshold2.14494668
22MP0002067_abnormal_sensory_capabilities2.10400004
23MP0008569_lethality_at_weaning2.08154211
24MP0006276_abnormal_autonomic_nervous2.07928816
25MP0004858_abnormal_nervous_system2.01992089
26MP0001440_abnormal_grooming_behavior1.99945800
27MP0005645_abnormal_hypothalamus_physiol1.96213527
28MP0002184_abnormal_innervation1.93805879
29MP0002822_catalepsy1.91076778
30MP0003122_maternal_imprinting1.89215151
31MP0001984_abnormal_olfaction1.84796552
32MP0003283_abnormal_digestive_organ1.79851707
33MP0005646_abnormal_pituitary_gland1.78586836
34MP0003787_abnormal_imprinting1.77230155
35MP0004811_abnormal_neuron_physiology1.76423539
36MP0002557_abnormal_social/conspecific_i1.75573895
37MP0003329_amyloid_beta_deposits1.75543078
38MP0004924_abnormal_behavior1.66445475
39MP0005386_behavior/neurological_phenoty1.66445475
40MP0000955_abnormal_spinal_cord1.62546626
41MP0000778_abnormal_nervous_system1.56318725
42MP0003879_abnormal_hair_cell1.49239577
43MP0002066_abnormal_motor_capabilities/c1.42522381
44MP0001502_abnormal_circadian_rhythm1.40630253
45MP0002882_abnormal_neuron_morphology1.39671668
46MP0003633_abnormal_nervous_system1.38240831
47MP0004885_abnormal_endolymph1.37290930
48MP0004145_abnormal_muscle_electrophysio1.31397030
49MP0004142_abnormal_muscle_tone1.29646174
50MP0010386_abnormal_urinary_bladder1.23155604
51MP0000013_abnormal_adipose_tissue1.22958268
52MP0003631_nervous_system_phenotype1.13814473
53MP0008961_abnormal_basal_metabolism1.10671988
54MP0004043_abnormal_pH_regulation1.09707450
55MP0002229_neurodegeneration1.08514190
56MP0002152_abnormal_brain_morphology1.07317836
57MP0002638_abnormal_pupillary_reflex1.04357515
58MP0000569_abnormal_digit_pigmentation1.03321195
59MP0008872_abnormal_physiological_respon0.98786856
60MP0002069_abnormal_eating/drinking_beha0.96098655
61MP0008877_abnormal_DNA_methylation0.94648308
62MP0001346_abnormal_lacrimal_gland0.94488303
63MP0000751_myopathy0.90692677
64MP0004742_abnormal_vestibular_system0.90671753
65MP0003123_paternal_imprinting0.90016066
66MP0005535_abnormal_body_temperature0.88837208
67MP0003690_abnormal_glial_cell0.88390040
68MP0003634_abnormal_glial_cell0.88173027
69MP0001348_abnormal_lacrimal_gland0.87093897
70MP0003632_abnormal_nervous_system0.86713448
71MP0004147_increased_porphyrin_level0.86248220
72MP0005394_taste/olfaction_phenotype0.86221254
73MP0005499_abnormal_olfactory_system0.86221254
74MP0000631_abnormal_neuroendocrine_gland0.86073495
75MP0001905_abnormal_dopamine_level0.85774576
76MP0001529_abnormal_vocalization0.85507217
77MP0005551_abnormal_eye_electrophysiolog0.82771293
78MP0001299_abnormal_eye_distance/0.82435316
79MP0006072_abnormal_retinal_apoptosis0.81946370
80MP0002837_dystrophic_cardiac_calcinosis0.79884299
81MP0003172_abnormal_lysosome_physiology0.77958696
82MP0003861_abnormal_nervous_system0.77598783
83MP0001177_atelectasis0.76413708
84MP0004085_abnormal_heartbeat0.76194331
85MP0008874_decreased_physiological_sensi0.75919085
86MP0002752_abnormal_somatic_nervous0.73421813
87MP0001963_abnormal_hearing_physiology0.72709476
88MP0003121_genomic_imprinting0.71605420
89MP0001188_hyperpigmentation0.69047036
90MP0000579_abnormal_nail_morphology0.68839557
91MP0000920_abnormal_myelination0.68809538
92MP0000604_amyloidosis0.68596898
93MP0001485_abnormal_pinna_reflex0.67481392
94MP0001986_abnormal_taste_sensitivity0.65675386
95MP0000566_synostosis0.65477210
96MP0005409_darkened_coat_color0.65454883
97MP0005167_abnormal_blood-brain_barrier0.65047030
98MP0003183_abnormal_peptide_metabolism0.64611057
99MP0004233_abnormal_muscle_weight0.64439053
100MP0003938_abnormal_ear_development0.64300356
101MP0003045_fibrosis0.60806505
102MP0010770_preweaning_lethality0.60669380
103MP0002082_postnatal_lethality0.60669380
104MP0010768_mortality/aging0.60432835
105MP0001943_abnormal_respiration0.59531985
106MP0005379_endocrine/exocrine_gland_phen0.59148372
107MP0002653_abnormal_ependyma_morphology0.58583813
108MP0004130_abnormal_muscle_cell0.57855323
109MP0003137_abnormal_impulse_conducting0.56865536
110MP0002693_abnormal_pancreas_physiology0.56804343
111MP0000026_abnormal_inner_ear0.56568264
112MP0003075_altered_response_to0.56295255
113MP0010769_abnormal_survival0.56165056
114MP0002090_abnormal_vision0.54925190
115MP0005623_abnormal_meninges_morphology0.52554075
116MP0003956_abnormal_body_size0.49989277
117MP0002081_perinatal_lethality0.48652929

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.82449598
2Myokymia (HP:0002411)5.99958376
3Visual hallucinations (HP:0002367)5.68615946
4Focal seizures (HP:0007359)5.47579318
5Atonic seizures (HP:0010819)4.74816776
6Progressive cerebellar ataxia (HP:0002073)4.57377143
7Action tremor (HP:0002345)4.52960082
8Febrile seizures (HP:0002373)4.38797829
9Epileptic encephalopathy (HP:0200134)4.25762683
10Absence seizures (HP:0002121)4.13304315
11Generalized tonic-clonic seizures (HP:0002069)3.79865624
12Supranuclear gaze palsy (HP:0000605)3.74552600
13Ankle clonus (HP:0011448)3.73433052
14Dialeptic seizures (HP:0011146)3.66023319
15Depression (HP:0000716)3.37320969
16Gaze-evoked nystagmus (HP:0000640)3.36933097
17Truncal ataxia (HP:0002078)3.28532010
18Papilledema (HP:0001085)3.27615857
19Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.24434024
20Dysdiadochokinesis (HP:0002075)3.23725202
21Poor eye contact (HP:0000817)3.17406978
22Broad-based gait (HP:0002136)3.15107505
23Obstructive sleep apnea (HP:0002870)3.12463122
24Urinary bladder sphincter dysfunction (HP:0002839)3.10954619
25Impaired smooth pursuit (HP:0007772)3.09160066
26Cerebral hypomyelination (HP:0006808)3.04897854
27Postural instability (HP:0002172)3.02689189
28Abnormal eating behavior (HP:0100738)3.02492393
29Impaired vibration sensation in the lower limbs (HP:0002166)2.97628627
30Anxiety (HP:0000739)2.97381644
31Agitation (HP:0000713)2.96155615
32Impaired social interactions (HP:0000735)2.95749151
33Abnormal social behavior (HP:0012433)2.95749151
34Ventricular fibrillation (HP:0001663)2.93660161
35Genetic anticipation (HP:0003743)2.90986891
36Hemiplegia (HP:0002301)2.90480516
37Dysmetria (HP:0001310)2.89772644
38Abnormality of the lower motor neuron (HP:0002366)2.89443201
39Pheochromocytoma (HP:0002666)2.88405723
40Mutism (HP:0002300)2.82059328
41Akinesia (HP:0002304)2.73236588
42Abnormality of ocular smooth pursuit (HP:0000617)2.72482056
43Spastic gait (HP:0002064)2.71492319
44Hemiparesis (HP:0001269)2.69704900
45Scanning speech (HP:0002168)2.65365848
46Sleep apnea (HP:0010535)2.63037510
47Amblyopia (HP:0000646)2.60872337
48Intention tremor (HP:0002080)2.57389319
49Failure to thrive in infancy (HP:0001531)2.57116019
50Peripheral hypomyelination (HP:0007182)2.55385717
51Urinary urgency (HP:0000012)2.51360570
52Dysmetric saccades (HP:0000641)2.50290517
53Insomnia (HP:0100785)2.49191031
54Bradykinesia (HP:0002067)2.48698079
55Progressive inability to walk (HP:0002505)2.48046081
56Neuroendocrine neoplasm (HP:0100634)2.47537588
57Apathy (HP:0000741)2.45141651
58Delusions (HP:0000746)2.42488433
59Diplopia (HP:0000651)2.42352325
60Abnormality of binocular vision (HP:0011514)2.42352325
61EEG with generalized epileptiform discharges (HP:0011198)2.41882427
62Epileptiform EEG discharges (HP:0011182)2.40878830
63Excessive salivation (HP:0003781)2.39176574
64Drooling (HP:0002307)2.39176574
65Hypsarrhythmia (HP:0002521)2.34076144
66Status epilepticus (HP:0002133)2.32308503
67Hyperventilation (HP:0002883)2.31974724
68Abnormality of the corticospinal tract (HP:0002492)2.30981920
69Postural tremor (HP:0002174)2.27838907
70Spastic tetraparesis (HP:0001285)2.27419608
71Clonus (HP:0002169)2.24594706
72Termporal pattern (HP:0011008)2.23983069
73Insidious onset (HP:0003587)2.23983069
74Lower limb muscle weakness (HP:0007340)2.22276383
75Diminished motivation (HP:0000745)2.21677132
76Limb dystonia (HP:0002451)2.19175641
77Torticollis (HP:0000473)2.16261693
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13516169
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.13516169
80Neurofibrillary tangles (HP:0002185)2.13488320
81Hypercortisolism (HP:0001578)2.13445059
82Menstrual irregularities (HP:0000858)2.12581081
83Fetal akinesia sequence (HP:0001989)2.09853348
84Megalencephaly (HP:0001355)2.09295007
85Incomplete penetrance (HP:0003829)2.07055598
86CNS hypomyelination (HP:0003429)2.06288645
87Bundle branch block (HP:0011710)2.04786034
88Abnormality of calcium-phosphate metabolism (HP:0100530)2.04482752
89Polyphagia (HP:0002591)2.02983091
90Stereotypic behavior (HP:0000733)2.02151926
91Neuronal loss in central nervous system (HP:0002529)2.01834315
92Cerebral inclusion bodies (HP:0100314)2.01515691
93Psychosis (HP:0000709)2.00583000
94Tetraplegia (HP:0002445)2.00182226
95Hypoventilation (HP:0002791)1.99925851
96Gait ataxia (HP:0002066)1.99219546
97Abnormality of saccadic eye movements (HP:0000570)1.98972823
98Impaired vibratory sensation (HP:0002495)1.97530350
99Pointed chin (HP:0000307)1.96509095
100Absent speech (HP:0001344)1.95704570
101Focal dystonia (HP:0004373)1.95206825
102Choreoathetosis (HP:0001266)1.94813556
103Amyotrophic lateral sclerosis (HP:0007354)1.90841804
104Rapidly progressive (HP:0003678)1.90768221
105Lower limb asymmetry (HP:0100559)1.89933540
106Resting tremor (HP:0002322)1.89132780
107Turricephaly (HP:0000262)1.88527269
108Bronchomalacia (HP:0002780)1.87582666
109Aplasia involving bones of the upper limbs (HP:0009823)1.85773376
110Aplasia of the phalanges of the hand (HP:0009802)1.85773376
111Aplasia involving bones of the extremities (HP:0009825)1.85773376
112Abnormal EKG (HP:0003115)1.85751624
113Neoplasm of the peripheral nervous system (HP:0100007)1.85351109
114Neoplasm of the heart (HP:0100544)1.83587942
115Lower limb amyotrophy (HP:0007210)1.81703377
116Annular pancreas (HP:0001734)1.81660216
117Macroorchidism (HP:0000053)1.81469832
118Rigidity (HP:0002063)1.81107940
119Spastic tetraplegia (HP:0002510)1.80409144
120Craniofacial dystonia (HP:0012179)1.77681118
121Specific learning disability (HP:0001328)1.77216222
122Generalized myoclonic seizures (HP:0002123)1.74548850
123Split foot (HP:0001839)1.73933900
124Morphological abnormality of the pyramidal tract (HP:0002062)1.72317088
125Spinal canal stenosis (HP:0003416)1.71799462
126Hand muscle atrophy (HP:0009130)1.71632555
127Thickened helices (HP:0000391)1.68152828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.56139622
2MAP3K93.99464953
3MAP3K43.25644784
4MARK12.98418437
5MINK12.74180699
6NTRK12.66279817
7DAPK22.58904291
8EPHA42.55646192
9MAP2K72.51016449
10NTRK22.44859059
11PAK62.42092772
12PRKD32.33891325
13MAP2K42.10523814
14CAMKK12.06658616
15MAP3K121.99418545
16KSR21.81778825
17CAMKK21.73286035
18CASK1.71121040
19STK381.65324454
20GRK51.59451553
21UHMK11.56290143
22CDK51.52069021
23MAP3K21.42077614
24RIPK41.40072728
25CDK191.38159107
26MAPK131.37565846
27PNCK1.34995469
28DAPK11.34495483
29SIK21.21669188
30TNIK1.20061374
31PRKCH1.18982743
32PRKCG1.18862227
33ALK1.13578516
34SGK4941.12931810
35SGK2231.12931810
36PHKG21.12367297
37PHKG11.12367297
38TYRO31.12243701
39PLK21.11729951
40KSR11.07154197
41RET1.06145061
42LATS21.04080132
43STK111.02911955
44SGK21.01704911
45ARAF0.97866949
46RIPK10.97258818
47CDC42BPA0.96248623
48PRPF4B0.96005614
49SGK30.94584467
50TAOK10.92790671
51SCYL20.92657691
52LMTK20.91706243
53WNK10.90896014
54PINK10.89367204
55CAMK10.86974356
56FES0.85894510
57CDK180.82225269
58TNK20.81988100
59CDK150.81626956
60CAMK2A0.80205629
61CDK140.79719090
62PAK30.79418707
63BRAF0.79276139
64MAP3K10.74287647
65CDK11A0.69661538
66CAMK1G0.68582847
67PKN10.66481816
68FGFR20.66131546
69MARK20.65840905
70MAPK120.65631682
71BRSK10.63835252
72OXSR10.63669999
73CSNK1G20.63261829
74SGK10.62726019
75DYRK1A0.62109189
76CAMK1D0.60796222
77HIPK20.59161958
78MAP3K110.59109068
79CAMK2B0.58882543
80RPS6KA30.55776653
81LIMK10.54587908
82MAPK100.53469246
83PDK10.53271306
84DAPK30.53116437
85RPS6KA20.52269351
86DYRK20.52122978
87INSRR0.51911138
88PDPK10.50637157
89NEK10.50572941
90MAP3K130.50419518
91ICK0.49835226
92CAMK40.49608104
93CAMK2D0.46805826
94CAMK2G0.46093946
95FER0.45607646
96RAF10.42505877
97AKT30.42379263
98PRKCZ0.41553577
99WNK30.41387188
100PRKCE0.41021482
101ROCK20.39219457
102PDGFRA0.37810103
103FYN0.37053794
104NEK60.33519021
105ERBB20.33255289
106PRKCB0.32892278
107MAP3K70.32091526
108CCNB10.30460190
109BMPR20.29525089
110PRKACA0.29109076
111CSNK1E0.28883134
112GSK3B0.28090993
113CSNK1D0.27870029
114PRKCA0.27690631
115MAPK80.27557835
116SRC0.24746800
117PRKG10.22687053
118PRKDC0.22337065

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.63371815
2Synaptic vesicle cycle_Homo sapiens_hsa047213.57485082
3GABAergic synapse_Homo sapiens_hsa047272.85482357
4Olfactory transduction_Homo sapiens_hsa047402.70963156
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59354710
6Circadian entrainment_Homo sapiens_hsa047132.56547173
7Glutamatergic synapse_Homo sapiens_hsa047242.48312450
8Long-term potentiation_Homo sapiens_hsa047202.46206563
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.45775709
10Insulin secretion_Homo sapiens_hsa049112.45680603
11Morphine addiction_Homo sapiens_hsa050322.44448746
12Amphetamine addiction_Homo sapiens_hsa050312.26368187
13Taste transduction_Homo sapiens_hsa047422.10138516
14Dopaminergic synapse_Homo sapiens_hsa047282.08440719
15Salivary secretion_Homo sapiens_hsa049702.04489455
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.92865475
17Gastric acid secretion_Homo sapiens_hsa049711.85560341
18Cholinergic synapse_Homo sapiens_hsa047251.83041106
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82156772
20Type II diabetes mellitus_Homo sapiens_hsa049301.68182911
21Long-term depression_Homo sapiens_hsa047301.67606564
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65203695
23Cocaine addiction_Homo sapiens_hsa050301.65022049
24Serotonergic synapse_Homo sapiens_hsa047261.56435826
25Renin secretion_Homo sapiens_hsa049241.48561314
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46913765
27Oxytocin signaling pathway_Homo sapiens_hsa049211.45550667
28Vitamin B6 metabolism_Homo sapiens_hsa007501.44917387
29Collecting duct acid secretion_Homo sapiens_hsa049661.42123097
30GnRH signaling pathway_Homo sapiens_hsa049121.41883785
31Calcium signaling pathway_Homo sapiens_hsa040201.38156808
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32227826
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31504445
34Estrogen signaling pathway_Homo sapiens_hsa049151.29613230
35Gap junction_Homo sapiens_hsa045401.27772136
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26780749
37cAMP signaling pathway_Homo sapiens_hsa040241.19981367
38Nitrogen metabolism_Homo sapiens_hsa009101.16729699
39Vibrio cholerae infection_Homo sapiens_hsa051101.10064671
40Pancreatic secretion_Homo sapiens_hsa049721.00848976
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97627713
42Thyroid hormone synthesis_Homo sapiens_hsa049180.97265714
43Glioma_Homo sapiens_hsa052140.95831510
44Melanogenesis_Homo sapiens_hsa049160.95682903
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95604655
46Dorso-ventral axis formation_Homo sapiens_hsa043200.94298968
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94139210
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94048004
49Cardiac muscle contraction_Homo sapiens_hsa042600.91769779
50Type I diabetes mellitus_Homo sapiens_hsa049400.91654255
51ErbB signaling pathway_Homo sapiens_hsa040120.90944833
52Oocyte meiosis_Homo sapiens_hsa041140.90536690
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.85318437
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.81541468
55Axon guidance_Homo sapiens_hsa043600.78763884
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72881390
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71513499
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.70314115
59MAPK signaling pathway_Homo sapiens_hsa040100.69820206
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68739146
61Dilated cardiomyopathy_Homo sapiens_hsa054140.66760139
62Inositol phosphate metabolism_Homo sapiens_hsa005620.64853893
63Glucagon signaling pathway_Homo sapiens_hsa049220.64209731
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64096974
65Bile secretion_Homo sapiens_hsa049760.61720932
66Circadian rhythm_Homo sapiens_hsa047100.61598479
67Phototransduction_Homo sapiens_hsa047440.60999878
68mTOR signaling pathway_Homo sapiens_hsa041500.60446642
69Choline metabolism in cancer_Homo sapiens_hsa052310.57297602
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57250127
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56348932
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54695460
73Alcoholism_Homo sapiens_hsa050340.54414101
74Insulin signaling pathway_Homo sapiens_hsa049100.53970915
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52698770
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52529928
77Endocytosis_Homo sapiens_hsa041440.50302986
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49876768
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.49809086
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48855768
81Endometrial cancer_Homo sapiens_hsa052130.48654928
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47136212
83Ovarian steroidogenesis_Homo sapiens_hsa049130.45760874
84Ras signaling pathway_Homo sapiens_hsa040140.45370736
85Prion diseases_Homo sapiens_hsa050200.44743844
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43639298
87VEGF signaling pathway_Homo sapiens_hsa043700.40918026
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.40666708
89Rap1 signaling pathway_Homo sapiens_hsa040150.39903056
90Prolactin signaling pathway_Homo sapiens_hsa049170.39083015
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36621910
92Hippo signaling pathway_Homo sapiens_hsa043900.35690461
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34319448
94Renal cell carcinoma_Homo sapiens_hsa052110.34233277
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.32227406
96Non-small cell lung cancer_Homo sapiens_hsa052230.31644222
97Tight junction_Homo sapiens_hsa045300.31547664
98Fatty acid biosynthesis_Homo sapiens_hsa000610.31266733
99Wnt signaling pathway_Homo sapiens_hsa043100.30774382
100Arginine biosynthesis_Homo sapiens_hsa002200.30476073
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30212245
102Alzheimers disease_Homo sapiens_hsa050100.29630084
103Arginine and proline metabolism_Homo sapiens_hsa003300.29472875
104Chemokine signaling pathway_Homo sapiens_hsa040620.29052120
105AMPK signaling pathway_Homo sapiens_hsa041520.28769798
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.24165931
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24064698
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22549721
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21751953
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21524165
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21196114
112HIF-1 signaling pathway_Homo sapiens_hsa040660.19889095

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