RIN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.59991904
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.59991904
3antigen processing and presentation of endogenous antigen (GO:0019883)5.25657894
4positive regulation of gamma-delta T cell activation (GO:0046645)5.02895033
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.57046756
6detection of other organism (GO:0098543)4.53216151
7detection of bacterium (GO:0016045)4.47433606
8positive regulation of B cell differentiation (GO:0045579)4.32970334
9leukocyte aggregation (GO:0070486)4.18693934
10negative regulation of phagocytosis (GO:0050765)4.09967995
11immunoglobulin mediated immune response (GO:0016064)4.01377024
12regulation of B cell receptor signaling pathway (GO:0050855)3.97753277
13regulation of B cell differentiation (GO:0045577)3.94678049
14neutrophil activation involved in immune response (GO:0002283)3.85437945
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.82807844
16negative regulation of lymphocyte mediated immunity (GO:0002707)3.77821968
17detection of external biotic stimulus (GO:0098581)3.71796913
18respiratory burst (GO:0045730)3.70692899
19regulation of gamma-delta T cell differentiation (GO:0045586)3.67991985
20Arp2/3 complex-mediated actin nucleation (GO:0034314)3.63040263
21regulation of gamma-delta T cell activation (GO:0046643)3.61650278
22cellular extravasation (GO:0045123)3.58540947
23regulation of mast cell activation involved in immune response (GO:0033006)3.57905261
24antigen processing and presentation via MHC class Ib (GO:0002475)3.54814907
25negative regulation of leukocyte mediated immunity (GO:0002704)3.54696978
26regulation of myeloid leukocyte mediated immunity (GO:0002886)3.54031137
27response to peptidoglycan (GO:0032494)3.53252422
28positive regulation by symbiont of host defense response (GO:0052509)3.50546140
29modulation by symbiont of host defense response (GO:0052031)3.50546140
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50546140
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50546140
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.50546140
33modulation by symbiont of host immune response (GO:0052553)3.50546140
34regulation of leukocyte degranulation (GO:0043300)3.48070606
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.47604941
36response to host immune response (GO:0052572)3.47604941
37negative regulation of T cell mediated immunity (GO:0002710)3.46815307
38regulation of T cell tolerance induction (GO:0002664)3.46476373
39detection of biotic stimulus (GO:0009595)3.38924037
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32836392
41regulation of tolerance induction (GO:0002643)3.32161119
42response to muramyl dipeptide (GO:0032495)3.31950461
43neutrophil activation (GO:0042119)3.31133464
44neutrophil mediated immunity (GO:0002446)3.30846566
45detection of molecule of bacterial origin (GO:0032490)3.28425959
46B cell receptor signaling pathway (GO:0050853)3.27987907
47regulation of interferon-beta biosynthetic process (GO:0045357)3.27140529
48B cell mediated immunity (GO:0019724)3.25858966
49response to host (GO:0075136)3.24737338
50response to host defenses (GO:0052200)3.24737338
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.24737338
52response to fungus (GO:0009620)3.23765600
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.22742591
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22413194
55T cell migration (GO:0072678)3.19451459
56cellular response to interleukin-15 (GO:0071350)3.17955292
57germinal center formation (GO:0002467)3.17717607
58negative regulation of interleukin-12 production (GO:0032695)3.17358891
59regulation of interleukin-12 biosynthetic process (GO:0045075)3.16283066
60T cell selection (GO:0045058)3.15937211
61microglial cell activation (GO:0001774)3.15039986
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13818924
63macrophage activation (GO:0042116)3.10159410
64NIK/NF-kappaB signaling (GO:0038061)3.09155082
65positive regulation of mast cell degranulation (GO:0043306)3.08601771
66positive regulation of mast cell activation involved in immune response (GO:0033008)3.08601771
67response to protozoan (GO:0001562)3.08232863
68negative regulation of granulocyte differentiation (GO:0030853)3.07955089
69granulocyte activation (GO:0036230)3.07869525
70regulation of antigen processing and presentation (GO:0002577)3.06693196
71thymic T cell selection (GO:0045061)3.06517775
72defense response to fungus (GO:0050832)3.06122621
73negative regulation of cell killing (GO:0031342)3.05847965
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05847965
75defense response to protozoan (GO:0042832)3.05281381
76negative regulation of cytokine production involved in immune response (GO:0002719)3.04583553
77myeloid dendritic cell activation (GO:0001773)3.03379516
78positive T cell selection (GO:0043368)3.03331737
79regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03320690
80negative regulation of innate immune response (GO:0045824)3.02954029
81regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.01924039
82regulation of natural killer cell mediated immunity (GO:0002715)3.01924039
83mast cell activation (GO:0045576)3.00403405
84production of molecular mediator involved in inflammatory response (GO:0002532)2.97914594
85positive thymic T cell selection (GO:0045059)2.97833806
86cellular response to zinc ion (GO:0071294)2.97215536
87leukocyte degranulation (GO:0043299)2.96763502
88leukocyte migration involved in inflammatory response (GO:0002523)2.96300238
89negative regulation of interleukin-6 production (GO:0032715)2.96218371
90killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.94267171
91disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.94267171
92response to type I interferon (GO:0034340)2.94121467
93positive regulation of interferon-alpha production (GO:0032727)2.91592939
94definitive hemopoiesis (GO:0060216)2.91583643
95cellular response to type I interferon (GO:0071357)2.91396879
96type I interferon signaling pathway (GO:0060337)2.91396879
97regulation of regulated secretory pathway (GO:1903305)2.89554491
98regulation of alpha-beta T cell proliferation (GO:0046640)2.89097999
99negative regulation of erythrocyte differentiation (GO:0045647)2.87754912
100response to interferon-beta (GO:0035456)2.87641456
101regulation of T-helper 2 cell differentiation (GO:0045628)2.86116145
102megakaryocyte development (GO:0035855)2.82610309
103interferon-gamma-mediated signaling pathway (GO:0060333)2.81423734
104ribosomal small subunit assembly (GO:0000028)2.80962412
105angiogenesis involved in wound healing (GO:0060055)2.80673485
106leukocyte cell-cell adhesion (GO:0007159)2.80487559
107actin nucleation (GO:0045010)2.79455505
108positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79014131
109regulation of growth of symbiont in host (GO:0044126)2.78798889
110negative regulation of growth of symbiont in host (GO:0044130)2.78798889
111negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.78798889
112modulation of growth of symbiont involved in interaction with host (GO:0044144)2.78798889
113regulation of T cell mediated cytotoxicity (GO:0001914)2.78479276
114myeloid cell activation involved in immune response (GO:0002275)2.78426594
115negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.77806078
116macrophage activation involved in immune response (GO:0002281)2.77559062
117positive regulation of antigen processing and presentation (GO:0002579)2.77183790
118tolerance induction (GO:0002507)2.76763801
119regulation of interferon-alpha production (GO:0032647)2.76554094
120myeloid dendritic cell differentiation (GO:0043011)2.75568404
121positive regulation of mast cell activation (GO:0033005)2.73932172
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73223179
123regulation of hypersensitivity (GO:0002883)2.72120352
124mature B cell differentiation (GO:0002335)2.69585282
125T cell homeostasis (GO:0043029)2.68662472
126regulation of mast cell activation (GO:0033003)2.68350880
127regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68182518
128negative thymic T cell selection (GO:0045060)2.68175935
129response to interleukin-15 (GO:0070672)2.67776649
130regulation of mast cell degranulation (GO:0043304)2.66699160
131regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65092772
132JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64524616
133myeloid leukocyte mediated immunity (GO:0002444)2.62601974
134macrophage differentiation (GO:0030225)2.61408356
135pinocytosis (GO:0006907)2.60158682
136cellular response to interferon-beta (GO:0035458)2.58823340
137negative T cell selection (GO:0043383)2.57684511
138regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56123057
139regulation of necroptotic process (GO:0060544)2.55310329
140regulation of response to interferon-gamma (GO:0060330)2.55187604
141positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.54443560
142interferon-gamma production (GO:0032609)2.53524588
143lymphocyte homeostasis (GO:0002260)2.52636180
144natural killer cell differentiation (GO:0001779)2.48703612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.37853709
2E2F7_22180533_ChIP-Seq_HELA_Human3.81512238
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.62939245
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.62677119
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57003769
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.32243756
7SCL_19346495_ChIP-Seq_HPC-7_Human3.30654594
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.27969570
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27306982
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.22005445
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15799842
12VDR_21846776_ChIP-Seq_THP-1_Human2.90959427
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.82979585
14MYC_22102868_ChIP-Seq_BL_Human2.81395833
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.72779829
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.72107372
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.71554131
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64731166
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63500074
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.43688928
21* SPI1_23547873_ChIP-Seq_NB4_Human2.40166740
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32138159
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28877274
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.27920652
25VDR_24763502_ChIP-Seq_THP-1_Human2.27640710
26MYB_26560356_Chip-Seq_TH2_Human2.27460262
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26505458
28MAF_26560356_Chip-Seq_TH1_Human2.24346180
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08919693
30* RUNX1_22412390_ChIP-Seq_EML_Mouse2.08916715
31MYB_26560356_Chip-Seq_TH1_Human2.06312638
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01686581
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00007289
34* RUNX_20019798_ChIP-Seq_JUKART_Human1.98303895
35UTX_26944678_Chip-Seq_JUKART_Human1.97245191
36TCF7_22412390_ChIP-Seq_EML_Mouse1.96606290
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94324361
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79257959
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77080583
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77067334
41* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76183362
42GATA1_22025678_ChIP-Seq_K562_Human1.75512718
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72955375
44SPI1_23127762_ChIP-Seq_K562_Human1.69208502
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66013067
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65964739
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65754871
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56714644
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50064651
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49482693
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.48452794
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.47987960
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46065556
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41325777
55MAF_26560356_Chip-Seq_TH2_Human1.40391879
56PU_27001747_Chip-Seq_BMDM_Mouse1.40290945
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39403654
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.38854104
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34932090
60* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32566839
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32457362
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31864087
63* GATA3_27048872_Chip-Seq_THYMUS_Human1.29649960
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29469733
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29123526
66* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28463902
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.28028857
68* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27376910
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26825101
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26698560
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26052959
72BCL6_27268052_Chip-Seq_Bcells_Human1.25182119
73* GATA1_19941827_ChIP-Seq_MEL_Mouse1.22847101
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20156437
75KDM2B_26808549_Chip-Seq_DND41_Human1.18485443
76BCOR_27268052_Chip-Seq_Bcells_Human1.16829697
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16581364
78* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13699164
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12101281
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11799990
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.10710532
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09112050
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08581540
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07442979
85CIITA_25753668_ChIP-Seq_RAJI_Human1.07233777
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07166737
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04790386
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.04730806
89* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04628578
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04617414
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04027113
92GATA3_26560356_Chip-Seq_TH2_Human1.04007964
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.01909150
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99970618
95SA1_27219007_Chip-Seq_ERYTHROID_Human0.99247100
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98906364
97* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97469720
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97067568
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96885086
100NCOR1_26117541_ChIP-Seq_K562_Human0.95817616
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95027883
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94139498
103PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94062025
104P68_20966046_ChIP-Seq_HELA_Human0.92425319
105RACK7_27058665_Chip-Seq_MCF-7_Human0.91931534
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88879552
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86537967
108VDR_24787735_ChIP-Seq_THP-1_Human0.85496708
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85403846
110GATA1_19941826_ChIP-Seq_K562_Human0.83493644
111FOXP3_21729870_ChIP-Seq_TREG_Human0.82472902
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81741527
113* LXR_22292898_ChIP-Seq_THP-1_Human0.81714151
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80869029
115VDR_23849224_ChIP-Seq_CD4+_Human0.80023040
116GATA2_19941826_ChIP-Seq_K562_Human0.79650375
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79466273
118SPI1_20517297_ChIP-Seq_HL60_Human0.79019748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.84290645
2MP0003436_decreased_susceptibility_to3.15501718
3MP0009785_altered_susceptibility_to2.99473002
4MP0003303_peritoneal_inflammation2.97197922
5MP0000685_abnormal_immune_system2.92831586
6MP0002396_abnormal_hematopoietic_system2.84682580
7MP0005671_abnormal_response_to2.83449556
8MP0001800_abnormal_humoral_immune2.72059681
9MP0002419_abnormal_innate_immunity2.70796577
10MP0005025_abnormal_response_to2.68008862
11MP0005387_immune_system_phenotype2.65263622
12MP0001790_abnormal_immune_system2.65263622
13MP0005000_abnormal_immune_tolerance2.58879548
14MP0002452_abnormal_antigen_presenting2.54295017
15MP0005464_abnormal_platelet_physiology2.46271422
16MP0002723_abnormal_immune_serum2.41502102
17MP0002420_abnormal_adaptive_immunity2.41285554
18MP0001819_abnormal_immune_cell2.40369253
19MP0002148_abnormal_hypersensitivity_rea2.37773674
20MP0003724_increased_susceptibility_to2.35783571
21MP0002398_abnormal_bone_marrow2.19522356
22MP0001545_abnormal_hematopoietic_system2.14891879
23MP0005397_hematopoietic_system_phenotyp2.14891879
24MP0001853_heart_inflammation2.14341733
25MP0004808_abnormal_hematopoietic_stem2.13584679
26MP0009278_abnormal_bone_marrow2.13436416
27MP0002405_respiratory_system_inflammati2.10493872
28MP0000716_abnormal_immune_system2.02105567
29MP0003763_abnormal_thymus_physiology2.01331057
30MP0002166_altered_tumor_susceptibility1.95211912
31MP0009333_abnormal_splenocyte_physiolog1.92731475
32MP0003300_gastrointestinal_ulcer1.87884228
33MP0010155_abnormal_intestine_physiology1.87694243
34MP0000689_abnormal_spleen_morphology1.85052672
35MP0000465_gastrointestinal_hemorrhage1.80564556
36MP0002722_abnormal_immune_system1.78761746
37MP0001845_abnormal_inflammatory_respons1.78307412
38MP0002429_abnormal_blood_cell1.75913694
39MP0001873_stomach_inflammation1.71045789
40MP0005174_abnormal_tail_pigmentation1.63128279
41MP0006082_CNS_inflammation1.62776558
42MP0004510_myositis1.61989832
43MP0008260_abnormal_autophagy1.60300803
44MP0002006_tumorigenesis1.56333350
45MP0003191_abnormal_cellular_cholesterol1.53299830
46MP0001533_abnormal_skeleton_physiology1.53225243
47MP0008469_abnormal_protein_level1.49899845
48MP0004947_skin_inflammation1.49663831
49MP0005451_abnormal_body_composition1.44691052
50MP0000343_altered_response_to1.42227734
51MP0000858_altered_metastatic_potential1.39175538
52MP0005058_abnormal_lysosome_morphology1.35667413
53MP0000703_abnormal_thymus_morphology1.34813558
54MP0000490_abnormal_crypts_of1.32773779
55MP0003866_abnormal_defecation1.26534444
56MP0009764_decreased_sensitivity_to1.25827036
57MP0003172_abnormal_lysosome_physiology1.21417466
58MP0003448_altered_tumor_morphology1.20884489
59MP0003828_pulmonary_edema1.19901008
60MP0009840_abnormal_foam_cell1.19388820
61MP0005075_abnormal_melanosome_morpholog1.10452644
62MP0004381_abnormal_hair_follicle1.07027488
63MP0002933_joint_inflammation1.05705663
64MP0003566_abnormal_cell_adhesion1.01412845
65MP0002019_abnormal_tumor_incidence0.99745353
66MP0002138_abnormal_hepatobiliary_system0.98536585
67MP0001851_eye_inflammation0.98480599
68MP0003183_abnormal_peptide_metabolism0.98423106
69MP0010307_abnormal_tumor_latency0.97299013
70MP0000604_amyloidosis0.96182056
71MP0009763_increased_sensitivity_to0.95141712
72MP0005310_abnormal_salivary_gland0.94908764
73MP0003690_abnormal_glial_cell0.93758387
74MP0000249_abnormal_blood_vessel0.93654915
75MP0010352_gastrointestinal_tract_polyps0.93417003
76MP0008057_abnormal_DNA_replication0.92079185
77MP0008004_abnormal_stomach_pH0.91946982
78MP0002132_abnormal_respiratory_system0.91516232
79MP0003806_abnormal_nucleotide_metabolis0.90468132
80MP0005164_abnormal_response_to0.89904489
81MP0003693_abnormal_embryo_hatching0.87565880
82MP0003075_altered_response_to0.84813236
83MP0005167_abnormal_blood-brain_barrier0.84628696
84MP0006054_spinal_hemorrhage0.79957871
85MP0002998_abnormal_bone_remodeling0.77486878
86MP0002277_abnormal_respiratory_mucosa0.77376816
87MP0005023_abnormal_wound_healing0.76492928
88MP0003656_abnormal_erythrocyte_physiolo0.75724768
89MP0005166_decreased_susceptibility_to0.75504025
90MP0000609_abnormal_liver_physiology0.75229808
91MP0005076_abnormal_cell_differentiation0.74532164
92MP0000015_abnormal_ear_pigmentation0.74452830
93MP0003795_abnormal_bone_structure0.73927077
94MP0001663_abnormal_digestive_system0.72382524
95MP0001986_abnormal_taste_sensitivity0.72180362
96MP0003091_abnormal_cell_migration0.71251940
97MP0000598_abnormal_liver_morphology0.70388259
98MP0003077_abnormal_cell_cycle0.70043086
99MP0003045_fibrosis0.69966311
100MP0009765_abnormal_xenobiotic_induced0.69190348
101MP0001879_abnormal_lymphatic_vessel0.64449625
102MP0010368_abnormal_lymphatic_system0.64047001
103MP0003943_abnormal_hepatobiliary_system0.63638988
104MP0004883_abnormal_blood_vessel0.63537671
105MP0003279_aneurysm0.63372410
106MP0008873_increased_physiological_sensi0.63218287
107MP0003186_abnormal_redox_activity0.62089623
108MP0002095_abnormal_skin_pigmentation0.61518663
109MP0005390_skeleton_phenotype0.61457778
110MP0005319_abnormal_enzyme/_coenzyme0.60768998
111MP0000371_diluted_coat_color0.60667541
112MP0010094_abnormal_chromosome_stability0.60653402
113MP0002928_abnormal_bile_duct0.60430193
114MP0002136_abnormal_kidney_physiology0.60364549
115MP0008874_decreased_physiological_sensi0.60191772
116MP0003453_abnormal_keratinocyte_physiol0.54479882
117MP0002009_preneoplasia0.52476351
118MP0001958_emphysema0.50318316
119MP0005381_digestive/alimentary_phenotyp0.48793750
120MP0002254_reproductive_system_inflammat0.46504018

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.51566000
2Eczematoid dermatitis (HP:0000976)5.17001706
3Recurrent bacterial skin infections (HP:0005406)5.02692593
4Myositis (HP:0100614)4.73259242
5Elevated erythrocyte sedimentation rate (HP:0003565)4.68174908
6Thrombocytosis (HP:0001894)4.16755808
7Recurrent gram-negative bacterial infections (HP:0005420)4.11819142
8Recurrent fungal infections (HP:0002841)4.07415383
9IgM deficiency (HP:0002850)4.01906521
10Recurrent viral infections (HP:0004429)3.83431330
11Chronic otitis media (HP:0000389)3.66322447
12Mediastinal lymphadenopathy (HP:0100721)3.65707742
13Orchitis (HP:0100796)3.64817110
14Recurrent skin infections (HP:0001581)3.64623588
15Abnormality of macrophages (HP:0004311)3.54483312
16Meningitis (HP:0001287)3.54179673
17Cellulitis (HP:0100658)3.42853106
18Petechiae (HP:0000967)3.40875010
19Retrobulbar optic neuritis (HP:0100654)3.35646887
20Optic neuritis (HP:0100653)3.35646887
21Chronic obstructive pulmonary disease (HP:0006510)3.35392128
22Obstructive lung disease (HP:0006536)3.35392128
23Prolonged bleeding time (HP:0003010)3.29279325
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.26703129
25Abnormality of liposaccharide metabolism (HP:0010968)3.21602096
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.21602096
27Abnormality of glycolipid metabolism (HP:0010969)3.21602096
28Chronic mucocutaneous candidiasis (HP:0002728)3.21455183
29Recurrent cutaneous fungal infections (HP:0011370)3.21455183
30Spontaneous hematomas (HP:0007420)3.19967137
31Vasculitis (HP:0002633)3.15899837
32Recurrent bronchitis (HP:0002837)3.07006938
33Panhypogammaglobulinemia (HP:0003139)3.02697959
34Epistaxis (HP:0000421)3.02609048
35Increased cerebral lipofuscin (HP:0011813)2.99152826
36Interstitial pulmonary disease (HP:0006530)2.95678265
37Inflammation of the large intestine (HP:0002037)2.95602794
38Arterial thrombosis (HP:0004420)2.92985399
39Gingival bleeding (HP:0000225)2.90874782
40Abnormal platelet function (HP:0011869)2.89513127
41Impaired platelet aggregation (HP:0003540)2.89513127
42Gastrointestinal inflammation (HP:0004386)2.88483258
43Nasal polyposis (HP:0100582)2.88458524
44Periodontitis (HP:0000704)2.87439495
45Abnormality of the nasal mucosa (HP:0000433)2.86345055
46Chest pain (HP:0100749)2.82381005
47Colitis (HP:0002583)2.80811383
48Abnormality of T cell physiology (HP:0011840)2.80007589
49Gastrointestinal infarctions (HP:0005244)2.78911511
50Pustule (HP:0200039)2.76238755
51Autoimmune thrombocytopenia (HP:0001973)2.74159221
52Hemoptysis (HP:0002105)2.68447564
53Episodic fever (HP:0001954)2.68261487
54Agammaglobulinemia (HP:0004432)2.67182807
55Leukocytosis (HP:0001974)2.66006205
56Pulmonary infiltrates (HP:0002113)2.65625496
57Increased IgM level (HP:0003496)2.64555377
58Dysostosis multiplex (HP:0000943)2.63274120
59Gingivitis (HP:0000230)2.61863507
60Abnormality of T cells (HP:0002843)2.58808176
61Amyloidosis (HP:0011034)2.57990809
62Loss of speech (HP:0002371)2.57006730
63Hypochromic anemia (HP:0001931)2.55646605
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.55553930
65Encephalitis (HP:0002383)2.52075923
66Abnormal platelet volume (HP:0011876)2.51727560
67Keratoconjunctivitis sicca (HP:0001097)2.49361780
68Increased serum ferritin (HP:0003281)2.48868931
69Stomatitis (HP:0010280)2.48829453
70Lymphopenia (HP:0001888)2.46848402
71Abnormality of the fingertips (HP:0001211)2.44913189
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.43450162
73Eosinophilia (HP:0001880)2.42603134
74Hypochromic microcytic anemia (HP:0004840)2.41952296
75Urticaria (HP:0001025)2.41104598
76Vacuolated lymphocytes (HP:0001922)2.39869449
77Osteomyelitis (HP:0002754)2.37775140
78Abnormality of B cell number (HP:0010975)2.35659881
79B lymphocytopenia (HP:0010976)2.35659881
80Granulocytopenia (HP:0001913)2.34391470
81Gastrointestinal stroma tumor (HP:0100723)2.32013617
82Abnormality of the prostate (HP:0008775)2.30311092
83Keratoconjunctivitis (HP:0001096)2.25479925
84Pulmonary embolism (HP:0002204)2.25215612
85Abnormality of iron homeostasis (HP:0011031)2.25141268
86Anorexia (HP:0002039)2.24145081
87Peritonitis (HP:0002586)2.21524543
88Hematochezia (HP:0002573)2.21164714
89Abnormality of eosinophils (HP:0001879)2.20775411
90Hepatosplenomegaly (HP:0001433)2.20321245
91Purpura (HP:0000979)2.20144667
92Thyroiditis (HP:0100646)2.16850288
93Skin ulcer (HP:0200042)2.16720941
94Autoimmune hemolytic anemia (HP:0001890)2.16559434
95Menorrhagia (HP:0000132)2.15682679
96Abnormality of the pleura (HP:0002103)2.14416543
97T lymphocytopenia (HP:0005403)2.10605110
98Abnormality of polysaccharide metabolism (HP:0011012)2.10233220
99Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10233220
100Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10233220
101Abnormality of T cell number (HP:0011839)2.09674681
102Acute myeloid leukemia (HP:0004808)2.09597933
103Thoracic kyphosis (HP:0002942)2.09121574
104IgA deficiency (HP:0002720)2.08732668
105Systemic lupus erythematosus (HP:0002725)2.07033085
106Increased IgE level (HP:0003212)2.06991437
107Increased mean platelet volume (HP:0011877)2.05945397
108Restrictive lung disease (HP:0002091)2.03974932
109Fatigue (HP:0012378)2.02466238
110Recurrent pneumonia (HP:0006532)2.02213327
111Gangrene (HP:0100758)2.01986436
112Abnormality of the peritoneum (HP:0002585)2.01873731
113Glomerulopathy (HP:0100820)2.00751958
114Joint hemorrhage (HP:0005261)1.99403027
115Microcytic anemia (HP:0001935)1.98442438
116Thrombophlebitis (HP:0004418)1.98379473
117Premature loss of primary teeth (HP:0006323)1.97168866
118Recurrent lower respiratory tract infections (HP:0002783)1.95011799
119Lymphoma (HP:0002665)1.94980317
120Urinary glycosaminoglycan excretion (HP:0003541)1.94433540
121Mucopolysacchariduria (HP:0008155)1.94433540
122Hypergammaglobulinemia (HP:0010702)1.93654398
123Papilloma (HP:0012740)1.93323608
124Verrucae (HP:0200043)1.93323608
125IgG deficiency (HP:0004315)1.92461055
126Recurrent sinusitis (HP:0011108)1.91405305
127Sepsis (HP:0100806)1.90542624
128Albinism (HP:0001022)1.89983597
129Arthralgia (HP:0002829)1.89379453
130Aplastic anemia (HP:0001915)1.88945329
131Viral hepatitis (HP:0006562)1.88879027
132Abnormality of the thoracic spine (HP:0100711)1.88795779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.65378712
2PRPF4B2.84611609
3IRAK42.81574072
4KIT2.58362196
5TYK22.48415852
6BTK2.39564611
7IRAK32.38155226
8JAK32.35403625
9EEF2K2.29359837
10ERN12.23749036
11TXK2.22972049
12TBK12.18696712
13ZAP702.12749006
14BLK2.12076030
15TEC2.10597764
16TAOK32.08323112
17MAP3K141.99593612
18STK101.93465728
19MAP2K31.85951926
20CSF1R1.75301295
21IKBKE1.72355070
22RIPK41.71252697
23FLT31.69021365
24TGFBR21.67362683
25PIM21.58806239
26SYK1.55227783
27ITK1.53403889
28PKN21.49791307
29FES1.47874780
30KDR1.46456572
31LRRK21.44644996
32GRK61.43990668
33JAK11.42290174
34TRIB31.41885945
35IKBKB1.38221824
36PIM11.37760747
37EPHB11.37512311
38HCK1.36575759
39FGR1.33339509
40CSK1.30646225
41MAP3K101.26241645
42TAOK21.21472384
43MAP3K11.20922760
44RPS6KA41.17438220
45LCK1.16582100
46NME21.11651372
47CLK11.11111049
48LYN1.08924100
49PRKD21.05911306
50MARK21.02218405
51SMG10.98129876
52FGFR40.96054045
53TRPM70.93420478
54CHUK0.93116581
55CDC42BPA0.92434119
56PAK40.91924097
57MATK0.91877129
58JAK20.90741614
59SIK20.84856816
60BMPR20.83532587
61TIE10.80237661
62MAPK70.78845037
63MAP3K130.77528200
64PTK60.76058978
65TTN0.75495002
66NLK0.75000774
67IRAK10.72895361
68HIPK20.71951813
69RPS6KB20.71507777
70MARK30.71078485
71MAP3K110.70960402
72PDPK10.69433810
73NEK90.68533769
74CDK40.68406571
75IRAK20.68394374
76SIK30.68358300
77STK40.67455847
78MAP3K120.67127506
79KSR20.66751777
80GRK70.64664439
81MAPKAPK30.64490302
82MAPK40.63532464
83NEK20.62156446
84FGFR30.61805628
85TGFBR10.61369561
86RPS6KA60.61137741
87CDK120.60363458
88MAP3K80.60192721
89CDK60.57145006
90FYN0.56817901
91MAPK110.55125928
92CAMKK10.54924943
93RIPK10.52502257
94YES10.51789672
95RPS6KC10.50651557
96RPS6KL10.50651557
97PRKG20.49882647
98MAPKAPK20.49592686
99MAP2K20.49078629
100BCKDK0.47724461
101CAMK1D0.47609933
102TESK20.44801694
103PIK3CG0.43111152
104ABL10.42987211
105MAP3K30.42610121
106SIK10.42606950
107DYRK1B0.42251817
108MAP3K50.41541540
109CAMKK20.41323530
110CDK70.40224869
111EIF2AK30.40161664
112MOS0.38387678
113TNK20.37653763
114PTK2B0.36740365
115MAP3K70.35827172
116EPHA30.34867593
117PDK10.34841889
118RPS6KA20.33995787
119STK240.32854287
120PRKCQ0.32523153
121RET0.31740040
122STK110.31487041
123STK380.31193841
124TAOK10.31127684
125MAPK120.30877219
126WEE10.30870897
127PRKCD0.30792496
128MAP3K60.30113072
129MAP2K60.29987897
130ATR0.29907199
131ALK0.29288184
132EGFR0.28816768

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.05088975
2Primary immunodeficiency_Homo sapiens_hsa053402.85422328
3B cell receptor signaling pathway_Homo sapiens_hsa046622.43174425
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.41389236
5Osteoclast differentiation_Homo sapiens_hsa043802.35012986
6Staphylococcus aureus infection_Homo sapiens_hsa051502.20242545
7Measles_Homo sapiens_hsa051622.14564042
8Hematopoietic cell lineage_Homo sapiens_hsa046402.13023048
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.12140743
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03558366
11Type I diabetes mellitus_Homo sapiens_hsa049401.98380220
12Antigen processing and presentation_Homo sapiens_hsa046121.96423028
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92205268
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89788695
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81681934
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76537992
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72699120
18Herpes simplex infection_Homo sapiens_hsa051681.71513437
19Pertussis_Homo sapiens_hsa051331.64079989
20Legionellosis_Homo sapiens_hsa051341.63465705
21DNA replication_Homo sapiens_hsa030301.63319229
22Toxoplasmosis_Homo sapiens_hsa051451.61283573
23Other glycan degradation_Homo sapiens_hsa005111.60737519
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59184912
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.56972678
26Acute myeloid leukemia_Homo sapiens_hsa052211.53542191
27Tuberculosis_Homo sapiens_hsa051521.52808355
28Asthma_Homo sapiens_hsa053101.51850069
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.48460136
30Shigellosis_Homo sapiens_hsa051311.47545191
31Allograft rejection_Homo sapiens_hsa053301.43841894
32Graft-versus-host disease_Homo sapiens_hsa053321.43399161
33Malaria_Homo sapiens_hsa051441.42721216
34Influenza A_Homo sapiens_hsa051641.42658692
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41290293
36Apoptosis_Homo sapiens_hsa042101.36651884
37Hepatitis B_Homo sapiens_hsa051611.34547353
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33192360
39TNF signaling pathway_Homo sapiens_hsa046681.32827214
40T cell receptor signaling pathway_Homo sapiens_hsa046601.31235393
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.29234301
42Platelet activation_Homo sapiens_hsa046111.23291402
43Caffeine metabolism_Homo sapiens_hsa002321.21362810
44Chemokine signaling pathway_Homo sapiens_hsa040621.20427214
45Ribosome_Homo sapiens_hsa030101.19729571
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17619023
47Chronic myeloid leukemia_Homo sapiens_hsa052201.16275118
48Viral myocarditis_Homo sapiens_hsa054161.13768626
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13187023
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08380271
51Base excision repair_Homo sapiens_hsa034101.07149481
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05423692
53Salmonella infection_Homo sapiens_hsa051321.01635886
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96094894
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95651100
56Pancreatic cancer_Homo sapiens_hsa052120.89581557
57Pentose phosphate pathway_Homo sapiens_hsa000300.89224949
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85996797
59Epstein-Barr virus infection_Homo sapiens_hsa051690.82676305
60Hepatitis C_Homo sapiens_hsa051600.82650438
61Complement and coagulation cascades_Homo sapiens_hsa046100.78818080
62Small cell lung cancer_Homo sapiens_hsa052220.78396629
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78273524
64Lysosome_Homo sapiens_hsa041420.77297540
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76935851
66African trypanosomiasis_Homo sapiens_hsa051430.76841481
67Mismatch repair_Homo sapiens_hsa034300.76108907
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75135339
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.73159122
70Homologous recombination_Homo sapiens_hsa034400.71816005
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71411849
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.70124532
73Viral carcinogenesis_Homo sapiens_hsa052030.68051286
74HTLV-I infection_Homo sapiens_hsa051660.68051029
75Endocytosis_Homo sapiens_hsa041440.67154805
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.64493707
77Renal cell carcinoma_Homo sapiens_hsa052110.64405998
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61966226
79p53 signaling pathway_Homo sapiens_hsa041150.57016409
80Non-small cell lung cancer_Homo sapiens_hsa052230.56157488
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55198582
82N-Glycan biosynthesis_Homo sapiens_hsa005100.54768469
83Renin-angiotensin system_Homo sapiens_hsa046140.54544816
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54295489
85Phagosome_Homo sapiens_hsa041450.53754128
86Non-homologous end-joining_Homo sapiens_hsa034500.53345122
87ABC transporters_Homo sapiens_hsa020100.53253732
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51392673
89Amoebiasis_Homo sapiens_hsa051460.50848617
90Rheumatoid arthritis_Homo sapiens_hsa053230.50089722
91GnRH signaling pathway_Homo sapiens_hsa049120.49954304
92Prolactin signaling pathway_Homo sapiens_hsa049170.49613139
93Choline metabolism in cancer_Homo sapiens_hsa052310.48957648
94Insulin resistance_Homo sapiens_hsa049310.48589636
95VEGF signaling pathway_Homo sapiens_hsa043700.48279990
96Notch signaling pathway_Homo sapiens_hsa043300.48037817
97HIF-1 signaling pathway_Homo sapiens_hsa040660.47340319
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47227830
99FoxO signaling pathway_Homo sapiens_hsa040680.46937180
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46628830
101MAPK signaling pathway_Homo sapiens_hsa040100.45705586
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45615512
103One carbon pool by folate_Homo sapiens_hsa006700.45557166
104mTOR signaling pathway_Homo sapiens_hsa041500.44344234
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.44199788
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43360815
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42184924
108Autoimmune thyroid disease_Homo sapiens_hsa053200.41720627
109Endometrial cancer_Homo sapiens_hsa052130.41370213
110Inositol phosphate metabolism_Homo sapiens_hsa005620.39912898
111Lysine degradation_Homo sapiens_hsa003100.38042949
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.37583329
113Bladder cancer_Homo sapiens_hsa052190.36650850
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.35756882
115Dorso-ventral axis formation_Homo sapiens_hsa043200.35423280
116Cell cycle_Homo sapiens_hsa041100.34946643
117Spliceosome_Homo sapiens_hsa030400.33409844
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33224520
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33052336
120Sulfur relay system_Homo sapiens_hsa041220.32280137
121Colorectal cancer_Homo sapiens_hsa052100.31458239
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31321411
123Rap1 signaling pathway_Homo sapiens_hsa040150.30188819
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30137094
125Vitamin digestion and absorption_Homo sapiens_hsa049770.28531615
126Type II diabetes mellitus_Homo sapiens_hsa049300.28021488
127Prostate cancer_Homo sapiens_hsa052150.26595842
128Prion diseases_Homo sapiens_hsa050200.26593277

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