RING1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)4.46947722
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.46947722
3L-phenylalanine catabolic process (GO:0006559)4.34070020
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.34070020
5positive regulation of triglyceride biosynthetic process (GO:0010867)4.13569527
6regulation of cholesterol homeostasis (GO:2000188)3.98430802
7alpha-linolenic acid metabolic process (GO:0036109)3.94821832
8protein retention in ER lumen (GO:0006621)3.90940193
9planar cell polarity pathway involved in neural tube closure (GO:0090179)3.79079066
10positive regulation of histone deacetylation (GO:0031065)3.67023962
11regulation of early endosome to late endosome transport (GO:2000641)3.65516808
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.61450837
13regulation of fatty acid beta-oxidation (GO:0031998)3.60925434
14positive regulation of fatty acid beta-oxidation (GO:0032000)3.50421615
15cell-cell junction maintenance (GO:0045217)3.50359750
16positive regulation of triglyceride metabolic process (GO:0090208)3.42601851
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.39616839
182-oxoglutarate metabolic process (GO:0006103)3.37495913
19dicarboxylic acid biosynthetic process (GO:0043650)3.35800768
20viral transcription (GO:0019083)3.34049186
21lysine catabolic process (GO:0006554)3.32191493
22lysine metabolic process (GO:0006553)3.32191493
23aromatic amino acid family catabolic process (GO:0009074)3.29248467
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.28825103
25sulfur amino acid catabolic process (GO:0000098)3.27659916
26activation of MAPKKK activity (GO:0000185)3.25419955
27semaphorin-plexin signaling pathway (GO:0071526)3.24590515
28protein localization to endosome (GO:0036010)3.23368771
29valine metabolic process (GO:0006573)3.21939583
30peptidyl-glutamic acid carboxylation (GO:0017187)3.21836083
31protein carboxylation (GO:0018214)3.21836083
32regulation of triglyceride biosynthetic process (GO:0010866)3.19466639
33barbed-end actin filament capping (GO:0051016)3.15839868
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.14618088
35negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.13332369
36glutamate metabolic process (GO:0006536)3.12830609
37apoptotic process involved in morphogenesis (GO:0060561)3.11764081
38negative regulation of erythrocyte differentiation (GO:0045647)3.10581858
39regulation of glucose import in response to insulin stimulus (GO:2001273)3.05295538
40basement membrane organization (GO:0071711)3.02521690
41modulation by symbiont of host cellular process (GO:0044068)3.00117668
42regulation of extracellular matrix disassembly (GO:0010715)2.99566633
43regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98563080
44stress fiber assembly (GO:0043149)2.98348392
45glyoxylate metabolic process (GO:0046487)2.97864838
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97377079
47maternal placenta development (GO:0001893)2.97059050
48negative regulation of fatty acid transport (GO:2000192)2.95495810
49negative regulation of sterol transport (GO:0032372)2.95196067
50negative regulation of cholesterol transport (GO:0032375)2.95196067
51positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.93607075
52aspartate family amino acid catabolic process (GO:0009068)2.91904897
53tricarboxylic acid metabolic process (GO:0072350)2.91716738
54kynurenine metabolic process (GO:0070189)2.90451666
55urea cycle (GO:0000050)2.90282163
56urea metabolic process (GO:0019627)2.90282163
57cysteine metabolic process (GO:0006534)2.89663289
58adherens junction assembly (GO:0034333)2.88906488
59negative regulation of cell size (GO:0045792)2.87923382
60bile acid biosynthetic process (GO:0006699)2.87576541
61translational termination (GO:0006415)2.87459695
62cellular modified amino acid catabolic process (GO:0042219)2.87371260
63epithelial cell differentiation involved in prostate gland development (GO:0060742)2.83869420
64modulation by virus of host process (GO:0019054)2.83147862
65positive regulation of lipid catabolic process (GO:0050996)2.82878796
66negative regulation of fibrinolysis (GO:0051918)2.82666867
67Golgi transport vesicle coating (GO:0048200)2.82615608
68COPI coating of Golgi vesicle (GO:0048205)2.82615608
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79895383
70ribosomal small subunit biogenesis (GO:0042274)2.77180969
71adhesion of symbiont to host (GO:0044406)2.75948736
72positive regulation of fatty acid biosynthetic process (GO:0045723)2.75719203
73creatine metabolic process (GO:0006600)2.74839766
74focal adhesion assembly (GO:0048041)2.73455355
75cell-substrate adherens junction assembly (GO:0007045)2.73455355
76retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73049530
77regulation of triglyceride metabolic process (GO:0090207)2.72791695
78protein-lipid complex assembly (GO:0065005)2.71774074
79positive regulation of fatty acid oxidation (GO:0046321)2.71700585
804-hydroxyproline metabolic process (GO:0019471)2.71639988
81regulation of gamma-delta T cell differentiation (GO:0045586)2.70050848
82regulation of fatty acid oxidation (GO:0046320)2.68239279
83complement activation, alternative pathway (GO:0006957)2.67434469
84endothelial cell chemotaxis (GO:0035767)2.65778094
85dicarboxylic acid catabolic process (GO:0043649)2.64912026
86regulation of triglyceride catabolic process (GO:0010896)2.64336924
87sodium ion export (GO:0071436)2.63792589
88ethanol oxidation (GO:0006069)2.63241921
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.63001324
90negative regulation of cell killing (GO:0031342)2.63001324
91negative regulation of lipid transport (GO:0032369)2.61289177
92positive regulation of extracellular matrix organization (GO:1903055)2.60727965
93virion attachment to host cell (GO:0019062)2.58155364
94adhesion of symbiont to host cell (GO:0044650)2.58155364
95positive regulation of glycogen biosynthetic process (GO:0045725)2.58140869
96alpha-amino acid catabolic process (GO:1901606)2.57748305
97nitrogen cycle metabolic process (GO:0071941)2.57742601
98response to laminar fluid shear stress (GO:0034616)2.57590982
99plasma lipoprotein particle clearance (GO:0034381)2.57111432
100atrioventricular valve morphogenesis (GO:0003181)2.56145276
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55604422
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55604422
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.55596504
104positive regulation of protein dephosphorylation (GO:0035307)2.55541301
105positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54787254
106skin morphogenesis (GO:0043589)2.53917852
107serine family amino acid catabolic process (GO:0009071)2.53609949
108regulation of NFAT protein import into nucleus (GO:0051532)2.53424419
109positive regulation of fatty acid metabolic process (GO:0045923)2.52892227
110embryo implantation (GO:0007566)2.52583432
111positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52124826
112high-density lipoprotein particle remodeling (GO:0034375)2.52043191
113indole-containing compound catabolic process (GO:0042436)2.50852619
114indolalkylamine catabolic process (GO:0046218)2.50852619
115tryptophan catabolic process (GO:0006569)2.50852619
116vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49787632
117modulation by virus of host morphology or physiology (GO:0019048)2.49319408
118regulation of ARF protein signal transduction (GO:0032012)2.49272448
119cellular amino acid catabolic process (GO:0009063)2.48653175
120regulation of extracellular matrix organization (GO:1903053)2.48610946
121positive thymic T cell selection (GO:0045059)2.48499909
122amino-acid betaine metabolic process (GO:0006577)2.47882102
123regulation of protein activation cascade (GO:2000257)2.47792545
124viral life cycle (GO:0019058)2.46128152
125positive regulation of glycogen metabolic process (GO:0070875)2.45920802
126reverse cholesterol transport (GO:0043691)2.45906064
127plasma lipoprotein particle assembly (GO:0034377)2.45898262
128positive regulation of lipoprotein lipase activity (GO:0051006)2.45733333
129positive regulation of triglyceride lipase activity (GO:0061365)2.45733333
130regulation of cholesterol storage (GO:0010885)2.44773437
131mannose metabolic process (GO:0006013)2.43017063
132bile acid metabolic process (GO:0008206)2.42804153
133glutamine family amino acid biosynthetic process (GO:0009084)2.42783221
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.42639770
135activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42505621
136peptidyl-tyrosine autophosphorylation (GO:0038083)2.42420802
137nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.42056366
138activation of Rac GTPase activity (GO:0032863)2.41912697
139UV protection (GO:0009650)2.41224968
140retrograde transport, endosome to Golgi (GO:0042147)2.40852255
141short-chain fatty acid metabolic process (GO:0046459)2.40413399
142regulation of cholesterol metabolic process (GO:0090181)2.40217404
143regulation of lipid catabolic process (GO:0050994)2.39982240
144translational elongation (GO:0006414)2.39514375
145convergent extension (GO:0060026)2.39276755
146pentose-phosphate shunt (GO:0006098)2.39243876
147fatty acid beta-oxidation (GO:0006635)2.37954602
148regulation of ARF GTPase activity (GO:0032312)2.37911055
149cytoskeletal anchoring at plasma membrane (GO:0007016)2.36354729
150embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35888851
151regulation of fibrinolysis (GO:0051917)2.34529448
152cortical actin cytoskeleton organization (GO:0030866)2.34454417
153activation of JUN kinase activity (GO:0007257)2.34407443
154regulation of complement activation (GO:0030449)2.34333186
155regulation of cholesterol biosynthetic process (GO:0045540)2.34117589
156positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33109009
157positive regulation of protein deacetylation (GO:0090312)2.32179398
158response to mercury ion (GO:0046689)2.31954904
159acylglycerol catabolic process (GO:0046464)2.31696565
160apoptotic process involved in development (GO:1902742)2.31370157
161protein targeting to plasma membrane (GO:0072661)2.29489199
162cellular protein complex disassembly (GO:0043624)2.29165266
163cell junction maintenance (GO:0034331)2.28908943
164positive regulation of nuclease activity (GO:0032075)2.27211325
165cochlea morphogenesis (GO:0090103)2.26896258
166cell-substrate junction assembly (GO:0007044)2.26425013
167positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.25332270
168pinocytosis (GO:0006907)2.25314021
169regulation of establishment of planar polarity (GO:0090175)2.24551428
170dopamine receptor signaling pathway (GO:0007212)2.24307622
171intracellular estrogen receptor signaling pathway (GO:0030520)2.23424914
172protein complex disassembly (GO:0043241)2.21940518
173cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.21758244
174glial cell migration (GO:0008347)2.21723149
175regulation of monocyte differentiation (GO:0045655)2.21608323
176negative regulation of catenin import into nucleus (GO:0035414)2.19055778
177cellular response to virus (GO:0098586)2.18883130
178low-density lipoprotein particle clearance (GO:0034383)2.18122211
179response to muramyl dipeptide (GO:0032495)2.18015578
180response to parathyroid hormone (GO:0071107)2.17139696
181cell migration in hindbrain (GO:0021535)2.16970896
182cell volume homeostasis (GO:0006884)2.16106839
183glucose catabolic process (GO:0006007)2.15578855
184actin filament bundle assembly (GO:0051017)2.14086085
185actin filament bundle organization (GO:0061572)2.14086085
186glycosphingolipid catabolic process (GO:0046479)2.13284171
1873-UTR-mediated mRNA stabilization (GO:0070935)2.12937437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.53095959
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.39371821
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.24574056
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.10184947
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90242377
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.86092088
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.67419405
8LXR_22292898_ChIP-Seq_THP-1_Human2.66903084
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.65280064
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.55400638
11MYC_22102868_ChIP-Seq_BL_Human2.53588442
12KDM2B_26808549_Chip-Seq_DND41_Human2.45975849
13VDR_21846776_ChIP-Seq_THP-1_Human2.35818991
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30828084
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20645494
16TCF7_22412390_ChIP-Seq_EML_Mouse2.17755314
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.16707258
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.15948295
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.09776497
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97143348
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.96946949
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.89808353
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87044194
24KDM2B_26808549_Chip-Seq_K562_Human1.84136358
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79245648
26RACK7_27058665_Chip-Seq_MCF-7_Human1.77978541
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76727296
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74667117
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70080923
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69050811
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68053157
32ZNF263_19887448_ChIP-Seq_K562_Human1.67975254
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66357536
34MAF_26560356_Chip-Seq_TH1_Human1.63768918
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58846386
36CLOCK_20551151_ChIP-Seq_293T_Human1.58025754
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57165711
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54932934
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49142651
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48760362
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48380294
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.48210479
43P68_20966046_ChIP-Seq_HELA_Human1.48157369
44VDR_24763502_ChIP-Seq_THP-1_Human1.47429232
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.46192326
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45356119
47CREB1_26743006_Chip-Seq_LNCaP_Human1.44157254
48UTX_26944678_Chip-Seq_JUKART_Human1.43718885
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42701091
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.39293763
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38213873
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.36839156
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36804042
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32871420
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32779925
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31485007
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31158878
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29706564
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26740831
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26337379
61SMC4_20622854_ChIP-Seq_HELA_Human1.25448865
62MAF_26560356_Chip-Seq_TH2_Human1.24556101
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24535937
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24076178
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23965468
66SCL_19346495_ChIP-Seq_HPC-7_Human1.23110149
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.22742118
68* TP53_22127205_ChIP-Seq_IMR90_Human1.21413494
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20969631
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20441571
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.20254131
72BCOR_27268052_Chip-Seq_Bcells_Human1.19107811
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.17560991
74GATA1_19941826_ChIP-Seq_K562_Human1.17371675
75DROSHA_22980978_ChIP-Seq_HELA_Human1.17294104
76CTCF_27219007_Chip-Seq_Bcells_Human1.15275344
77CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15100625
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14936165
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.14463873
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14029501
81* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13520359
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12699552
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12531144
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12312607
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11040777
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11014290
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.10719025
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10233363
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09754293
90* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08981104
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07600497
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06476476
93BCL6_27268052_Chip-Seq_Bcells_Human1.06258675
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05721020
95SPI1_23127762_ChIP-Seq_K562_Human1.05613242
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05430394
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.05035162
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.05035162
99* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04914782
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.04127132
101* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03949295
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.03623930
103SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03379645
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.03180499
105* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02586497
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.02138972
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.01766972
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01306797
109RARA_24833708_ChIP-Seq_LIVER_Mouse1.00481953
110SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00278316
111SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00133566
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00068080
113ATF3_27146783_Chip-Seq_COLON_Human0.99652881
114NCOR1_26117541_ChIP-Seq_K562_Human0.98913605
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98392048
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98325640
117CTCF_21964334_Chip-Seq_Bcells_Human0.98297948
118STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97626960
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.96960984
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96817869
121SA1_27219007_Chip-Seq_Bcells_Human0.96801699
122TP63_22573176_ChIP-Seq_HFKS_Human0.96322321
123CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95713775
124* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94407509
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94074838
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92757426
127KLF4_19829295_ChIP-Seq_ESCs_Human0.91634127
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90740908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.61241432
2MP0002139_abnormal_hepatobiliary_system4.49479124
3MP0005365_abnormal_bile_salt3.80408928
4MP0009840_abnormal_foam_cell3.61028571
5MP0008961_abnormal_basal_metabolism3.22383932
6MP0005085_abnormal_gallbladder_physiolo2.99736995
7MP0003705_abnormal_hypodermis_morpholog2.81417099
8MP0003303_peritoneal_inflammation2.78720898
9MP0009379_abnormal_foot_pigmentation2.73903213
10MP0003252_abnormal_bile_duct2.68248437
11MP0003300_gastrointestinal_ulcer2.59825929
12MP0010329_abnormal_lipoprotein_level2.46711925
13MP0005451_abnormal_body_composition2.46692191
14MP0005257_abnormal_intraocular_pressure2.39775343
15MP0004130_abnormal_muscle_cell2.38093783
16MP0003191_abnormal_cellular_cholesterol2.32436288
17MP0008875_abnormal_xenobiotic_pharmacok2.25896083
18MP0001348_abnormal_lacrimal_gland2.25093393
19MP0005083_abnormal_biliary_tract2.15584319
20MP0004185_abnormal_adipocyte_glucose2.09792527
21MP0004510_myositis2.09008511
22MP0002249_abnormal_larynx_morphology2.05968105
23MP0000678_abnormal_parathyroid_gland1.96680966
24MP0004859_abnormal_synaptic_plasticity1.88443324
25MP0005503_abnormal_tendon_morphology1.86296928
26MP0000685_abnormal_immune_system1.84895721
27MP0003329_amyloid_beta_deposits1.80598392
28MP0003436_decreased_susceptibility_to1.79192878
29MP0000609_abnormal_liver_physiology1.76055463
30MP0005332_abnormal_amino_acid1.73972512
31MP0005409_darkened_coat_color1.73301270
32MP0003656_abnormal_erythrocyte_physiolo1.70143218
33MP0006054_spinal_hemorrhage1.69597918
34MP0010030_abnormal_orbit_morphology1.69548366
35MP0002118_abnormal_lipid_homeostasis1.67864188
36MP0003453_abnormal_keratinocyte_physiol1.63391004
37MP0008260_abnormal_autophagy1.62429142
38MP0002909_abnormal_adrenal_gland1.59344680
39MP0005666_abnormal_adipose_tissue1.56128585
40MP0009278_abnormal_bone_marrow1.54169872
41MP0005375_adipose_tissue_phenotype1.53850597
42MP0003123_paternal_imprinting1.50988243
43MP0000604_amyloidosis1.50951272
44MP0000747_muscle_weakness1.48302334
45MP0005584_abnormal_enzyme/coenzyme_acti1.40621160
46MP0005058_abnormal_lysosome_morphology1.38680574
47MP0000003_abnormal_adipose_tissue1.38303198
48MP0002877_abnormal_melanocyte_morpholog1.37874065
49MP0001666_abnormal_nutrient_absorption1.37077890
50MP0002653_abnormal_ependyma_morphology1.36701905
51MP0003075_altered_response_to1.34413163
52MP0003634_abnormal_glial_cell1.32370845
53MP0005319_abnormal_enzyme/_coenzyme1.32035274
54MP0000751_myopathy1.31793228
55MP0009384_cardiac_valve_regurgitation1.31196869
56MP0002822_catalepsy1.28871386
57MP0003879_abnormal_hair_cell1.21369761
58MP0005508_abnormal_skeleton_morphology1.19337614
59MP0003283_abnormal_digestive_organ1.17975197
60MP0005023_abnormal_wound_healing1.16966433
61MP0004087_abnormal_muscle_fiber1.15463218
62MP0004858_abnormal_nervous_system1.15085150
63MP0000858_altered_metastatic_potential1.14409311
64MP0009780_abnormal_chondrocyte_physiolo1.12821521
65MP0000681_abnormal_thyroid_gland1.12661057
66MP0003942_abnormal_urinary_system1.10717087
67MP0009643_abnormal_urine_homeostasis1.10262484
68MP0002998_abnormal_bone_remodeling1.08105478
69MP0000733_abnormal_muscle_development1.03341904
70MP0003195_calcinosis1.02398463
71MP0002896_abnormal_bone_mineralization1.00834510
72MP0000767_abnormal_smooth_muscle1.00154585
73MP0008874_decreased_physiological_sensi0.98096336
74MP0002269_muscular_atrophy0.97379338
75MP0002078_abnormal_glucose_homeostasis0.97237480
76MP0005220_abnormal_exocrine_pancreas0.97160972
77MP0009333_abnormal_splenocyte_physiolog0.96707216
78MP0005390_skeleton_phenotype0.96687485
79MP0001851_eye_inflammation0.96611675
80MP0008569_lethality_at_weaning0.95461669
81MP0000343_altered_response_to0.94928298
82MP0002138_abnormal_hepatobiliary_system0.93451886
83MP0003172_abnormal_lysosome_physiology0.92966974
84MP0002254_reproductive_system_inflammat0.92771901
85MP0003122_maternal_imprinting0.92214935
86MP0005275_abnormal_skin_tensile0.91928216
87MP0001958_emphysema0.91576918
88MP0009053_abnormal_anal_canal0.91501410
89MP0003806_abnormal_nucleotide_metabolis0.90545921
90MP0002933_joint_inflammation0.90041622
91MP0003045_fibrosis0.89854766
92MP0002060_abnormal_skin_morphology0.88511356
93MP0010630_abnormal_cardiac_muscle0.88317396
94MP0004145_abnormal_muscle_electrophysio0.87832913
95MP0001765_abnormal_ion_homeostasis0.87478802
96MP0001533_abnormal_skeleton_physiology0.86844532
97MP0001944_abnormal_pancreas_morphology0.85531175
98MP0000759_abnormal_skeletal_muscle0.85468305
99MP0005423_abnormal_somatic_nervous0.84660232
100MP0000920_abnormal_myelination0.84322130
101MP0000598_abnormal_liver_morphology0.83779394
102MP0003279_aneurysm0.83774901
103MP0005166_decreased_susceptibility_to0.83405947
104MP0000534_abnormal_ureter_morphology0.82162357
105MP0000566_synostosis0.82147619
106MP0003633_abnormal_nervous_system0.81009486
107MP0003690_abnormal_glial_cell0.80052876
108MP0005330_cardiomyopathy0.79885756
109MP0005387_immune_system_phenotype0.79681124
110MP0001790_abnormal_immune_system0.79681124
111MP0005623_abnormal_meninges_morphology0.79633347
112MP0002089_abnormal_postnatal_growth/wei0.78667588
113MP0000750_abnormal_muscle_regeneration0.77986552
114MP0002113_abnormal_skeleton_development0.77246195
115MP0004947_skin_inflammation0.76366736
116MP0000537_abnormal_urethra_morphology0.74778912
117MP0003566_abnormal_cell_adhesion0.74741922
118MP0002932_abnormal_joint_morphology0.74411465
119MP0001849_ear_inflammation0.74357557
120MP0002971_abnormal_brown_adipose0.73972995
121MP0005464_abnormal_platelet_physiology0.73867332
122MP0005076_abnormal_cell_differentiation0.73536934
123MP0000013_abnormal_adipose_tissue0.73474812
124MP0002837_dystrophic_cardiac_calcinosis0.72544715
125MP0002116_abnormal_craniofacial_bone0.71241427
126MP0005670_abnormal_white_adipose0.70797041
127MP0009642_abnormal_blood_homeostasis0.70382563
128MP0000749_muscle_degeneration0.70177009
129MP0004885_abnormal_endolymph0.69864816
130MP0005167_abnormal_blood-brain_barrier0.69467556
131MP0005334_abnormal_fat_pad0.69259692
132MP0001545_abnormal_hematopoietic_system0.68557996
133MP0005397_hematopoietic_system_phenotyp0.68557996
134MP0001502_abnormal_circadian_rhythm0.68017145
135MP0001853_heart_inflammation0.68008362
136MP0010234_abnormal_vibrissa_follicle0.67745152
137MP0003011_delayed_dark_adaptation0.67569170
138MP0008469_abnormal_protein_level0.67111677
139MP0002796_impaired_skin_barrier0.66218477
140MP0003091_abnormal_cell_migration0.64307401
141MP0009115_abnormal_fat_cell0.63414508
142MP0004233_abnormal_muscle_weight0.63239884
143MP0005501_abnormal_skin_physiology0.63125528
144MP0001542_abnormal_bone_strength0.61704264
145MP0001873_stomach_inflammation0.61596387
146MP0002970_abnormal_white_adipose0.61129494
147MP0003115_abnormal_respiratory_system0.60646143
148MP0001756_abnormal_urination0.60443587
149MP0001270_distended_abdomen0.60431395
150MP0002108_abnormal_muscle_morphology0.60316042
151MP0008438_abnormal_cutaneous_collagen0.58366747
152MP0003866_abnormal_defecation0.57193874
153MP0005636_abnormal_mineral_homeostasis0.56836047
154MP0002419_abnormal_innate_immunity0.56502404
155MP0003948_abnormal_gas_homeostasis0.56364160
156MP0002092_abnormal_eye_morphology0.56271628
157MP0005535_abnormal_body_temperature0.55311873

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.02062691
2Deep venous thrombosis (HP:0002625)4.01143515
3Xanthomatosis (HP:0000991)3.58307566
4Obstructive sleep apnea (HP:0002870)3.56024418
5Ketosis (HP:0001946)3.42182794
6Hyperlipoproteinemia (HP:0010980)3.27995885
7Hyperacusis (HP:0010780)3.09693716
8Cerebral aneurysm (HP:0004944)3.08194409
9Abnormality of the Achilles tendon (HP:0005109)3.00401410
10Cervical subluxation (HP:0003308)2.93577030
11Intrahepatic cholestasis (HP:0001406)2.89977272
12Ketoacidosis (HP:0001993)2.88113178
13Vertebral compression fractures (HP:0002953)2.86376623
14Thin bony cortex (HP:0002753)2.79753830
15Achilles tendon contracture (HP:0001771)2.79004746
16Mitral regurgitation (HP:0001653)2.73003552
17Complement deficiency (HP:0004431)2.69207313
18Insomnia (HP:0100785)2.63158974
19Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59116693
20Nuclear cataract (HP:0100018)2.56576853
21Turricephaly (HP:0000262)2.55469317
22Broad face (HP:0000283)2.54969027
23Striae distensae (HP:0001065)2.54766234
24Myocardial infarction (HP:0001658)2.53101729
25Hyperammonemia (HP:0001987)2.52756602
26Abnormality of the nasal mucosa (HP:0000433)2.47381934
27Exercise-induced myalgia (HP:0003738)2.44404673
28Polycythemia (HP:0001901)2.39984405
29Fragile skin (HP:0001030)2.35691308
30Hypoglycemic coma (HP:0001325)2.34275117
31Broad metatarsal (HP:0001783)2.33921046
32Shallow orbits (HP:0000586)2.33798492
33Late onset (HP:0003584)2.30063185
34Ulnar bowing (HP:0003031)2.28317790
35Hemiplegia (HP:0002301)2.27650143
36Nasal polyposis (HP:0100582)2.27391921
37Abnormality of the common coagulation pathway (HP:0010990)2.27288876
38Abnormality of complement system (HP:0005339)2.26720711
39Biconcave vertebral bodies (HP:0004586)2.26409576
40Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26187433
41Atelectasis (HP:0100750)2.25822611
42Hyperglycinuria (HP:0003108)2.24567875
43Hypercholesterolemia (HP:0003124)2.24393499
44Joint stiffness (HP:0001387)2.23480613
45Hyperparathyroidism (HP:0000843)2.22524024
46Abnormality of glycine metabolism (HP:0010895)2.21215048
47Abnormality of serine family amino acid metabolism (HP:0010894)2.21215048
48Abnormality of the thoracic spine (HP:0100711)2.20809607
49Distal upper limb amyotrophy (HP:0007149)2.19443705
50Upper limb amyotrophy (HP:0009129)2.19443705
51Systemic lupus erythematosus (HP:0002725)2.18982371
52Neonatal onset (HP:0003623)2.18966747
53Genu recurvatum (HP:0002816)2.17981919
54Blue sclerae (HP:0000592)2.14913509
55Distal lower limb amyotrophy (HP:0008944)2.13719485
56Spinal rigidity (HP:0003306)2.11777478
57Hyperglycinemia (HP:0002154)2.11651993
58Supranuclear gaze palsy (HP:0000605)2.10862210
59Prolonged partial thromboplastin time (HP:0003645)2.10409809
60Short nail (HP:0001799)2.10396473
61Hypobetalipoproteinemia (HP:0003563)2.10141571
62Increased connective tissue (HP:0009025)2.07868409
63Elfin facies (HP:0004428)2.07726566
64J-shaped sella turcica (HP:0002680)2.07448840
65Gout (HP:0001997)2.06903701
66Thoracic kyphosis (HP:0002942)2.05704535
67Renovascular hypertension (HP:0100817)2.03875805
68Hyperthyroidism (HP:0000836)2.03700367
69Flat acetabular roof (HP:0003180)2.02734011
70Hemorrhage of the eye (HP:0011885)2.02002286
71Aneurysm (HP:0002617)2.01044521
72Round ear (HP:0100830)2.00265223
73Overriding aorta (HP:0002623)1.99856383
74Long palpebral fissure (HP:0000637)1.99574894
75Distal lower limb muscle weakness (HP:0009053)1.99442088
76Status epilepticus (HP:0002133)1.98997972
77Abnormality of dentin (HP:0010299)1.98789253
78Disproportionate tall stature (HP:0001519)1.97782239
79Mitral valve prolapse (HP:0001634)1.96323754
80Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95688533
81Joint hemorrhage (HP:0005261)1.94694805
82Neurofibrillary tangles (HP:0002185)1.93994676
83Colitis (HP:0002583)1.93912546
84Bronchomalacia (HP:0002780)1.92882315
85Myoglobinuria (HP:0002913)1.92517953
86Lymphangioma (HP:0100764)1.92333981
87Hypoalphalipoproteinemia (HP:0003233)1.91862441
88Urinary glycosaminoglycan excretion (HP:0003541)1.91592221
89Mucopolysacchariduria (HP:0008155)1.91592221
90Mitral stenosis (HP:0001718)1.90612236
91Pointed chin (HP:0000307)1.90507170
92Arnold-Chiari malformation (HP:0002308)1.89588090
93Protrusio acetabuli (HP:0003179)1.88807190
94Cerebral inclusion bodies (HP:0100314)1.88753100
95Renal duplication (HP:0000075)1.88448426
96Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87666422
97Emphysema (HP:0002097)1.87125348
98Annular pancreas (HP:0001734)1.87077272
99Dysmetric saccades (HP:0000641)1.86905251
100Back pain (HP:0003418)1.86529022
101Mildly elevated creatine phosphokinase (HP:0008180)1.86078134
102Dysostosis multiplex (HP:0000943)1.85756557
103Segmental peripheral demyelination/remyelination (HP:0003481)1.85593365
104Polygenic inheritance (HP:0010982)1.85007862
105Axonal loss (HP:0003447)1.84586642
106Abnormality of polysaccharide metabolism (HP:0011012)1.84276179
107Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84276179
108Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84276179
109Asymmetry of the thorax (HP:0001555)1.83271338
110Cupped ribs (HP:0000887)1.82354834
111Increased variability in muscle fiber diameter (HP:0003557)1.82201937
112Hand muscle atrophy (HP:0009130)1.81076708
113Hypolipoproteinemia (HP:0010981)1.80902755
114Abnormality of glycolipid metabolism (HP:0010969)1.80813036
115Abnormality of liposaccharide metabolism (HP:0010968)1.80813036
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.80813036
117Gastrointestinal inflammation (HP:0004386)1.80792471
118Stridor (HP:0010307)1.80774979
119Reticulocytosis (HP:0001923)1.80741714
120Metaphyseal cupping (HP:0003021)1.80690316
121Abnormality of skeletal muscle fiber size (HP:0012084)1.80456974
122Death in childhood (HP:0003819)1.79358211
123Esophageal varix (HP:0002040)1.78812320
124Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78811025
125Abnormal platelet function (HP:0011869)1.77801517
126Impaired platelet aggregation (HP:0003540)1.77801517
127Neoplasm of the heart (HP:0100544)1.76738706
128Broad distal phalanx of finger (HP:0009836)1.76582473
129Depression (HP:0000716)1.76023849
130Inflammation of the large intestine (HP:0002037)1.74404338
131Long toe (HP:0010511)1.73763305
132Abnormality of the lower motor neuron (HP:0002366)1.73414576
133Premature rupture of membranes (HP:0001788)1.73063596
134Vascular tortuosity (HP:0004948)1.73054206
135Atrophic scars (HP:0001075)1.72318165
136Asymmetric septal hypertrophy (HP:0001670)1.72011609
137Spinal cord compression (HP:0002176)1.71791345
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.71775400
139Patellar dislocation (HP:0002999)1.71338929
140Neuronal loss in central nervous system (HP:0002529)1.70613242
141Dilatation of the ascending aorta (HP:0005111)1.70396211
142Hyporeflexia of lower limbs (HP:0002600)1.70131295
143Congenital glaucoma (HP:0001087)1.69579535
144Rapidly progressive (HP:0003678)1.69506267
145Spastic diplegia (HP:0001264)1.68260686
146Sudden death (HP:0001699)1.67618541
147Wormian bones (HP:0002645)1.67466728
148Hypertensive crisis (HP:0100735)1.67146376
149Hyperextensible skin (HP:0000974)1.66997180
150Cellulitis (HP:0100658)1.66510631
151Limb-girdle muscle atrophy (HP:0003797)1.66469131
152Papilloma (HP:0012740)1.66263741
153Verrucae (HP:0200043)1.66263741
154Bladder diverticulum (HP:0000015)1.66126636
155Myopathic facies (HP:0002058)1.65947628
156Truncus arteriosus (HP:0001660)1.65358897
157Neonatal short-limb short stature (HP:0008921)1.65164829
158Venous abnormality (HP:0002624)1.64928410
159Generalized hyperpigmentation (HP:0007440)1.64196792
160Premature skin wrinkling (HP:0100678)1.63164966
161Abnormal ossification of hand bones (HP:0005921)1.63104443
162Thin ribs (HP:0000883)1.63088850
163Ankle contracture (HP:0006466)1.62851265
164Joint laxity (HP:0001388)1.62590681
165Stroke (HP:0001297)1.61067729
166Delayed CNS myelination (HP:0002188)1.59257930
167Retinal atrophy (HP:0001105)1.58634668
168Hypercortisolism (HP:0001578)1.58327120
169Amyloidosis (HP:0011034)1.57890786
170Aortic aneurysm (HP:0004942)1.57521867
171Abnormality of fatty-acid metabolism (HP:0004359)1.57052591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.19308616
2ERN13.40913121
3PRPF4B3.24111656
4SIK13.18701962
5MAP3K103.03239546
6PKN22.96879425
7SMG12.59184158
8FGFR42.35242969
9IRAK32.33719812
10EEF2K2.33293263
11PTK62.07692934
12BCKDK2.01052523
13MAP4K11.75813778
14ICK1.67767492
15MAP3K71.65371149
16MAPK151.54378703
17EPHB11.54226189
18NME21.54208930
19TAOK11.51802392
20PRKD31.51745583
21PRKD21.49270579
22TESK11.42399659
23PRKCH1.42390449
24TAOK21.42257701
25TTN1.37798259
26SIK21.35771405
27DDR21.31927393
28CAMK1G1.29840298
29LRRK21.28778964
30TBK11.27715481
31PDGFRA1.26165962
32ARAF1.25541187
33CDK121.21746022
34MARK21.21534662
35LMTK21.19081219
36DMPK1.15916891
37DAPK21.15513978
38EPHA21.13145286
39TGFBR21.10669610
40KIT1.08819216
41RIPK11.08278643
42RIPK41.07727791
43TYK21.04658426
44LATS21.04632660
45TLK11.02487469
46TAOK31.01583253
47JAK30.99220879
48HIPK20.97230723
49PRKD10.94941007
50NTRK20.92730903
51BTK0.90804388
52MAP3K110.89297784
53BMX0.87612011
54MAP2K30.86888405
55PHKG10.86361134
56PHKG20.86361134
57FLT30.86301960
58JAK20.86056425
59MAP3K60.85360078
60MAP3K10.84671165
61CAMKK10.84636131
62RPS6KC10.84072006
63RPS6KL10.84072006
64JAK10.83208646
65DYRK1B0.82066061
66RET0.81972500
67PIM20.80995701
68CAMK1D0.80906329
69MTOR0.80656621
70MAPK110.80640135
71TNK20.78956381
72ALK0.78395608
73PDPK10.77015689
74MAP3K90.76365193
75TYRO30.75952141
76STK380.75487402
77PDK10.75466229
78SGK30.75176844
79EPHB20.75021662
80WNK40.73172365
81MAP3K30.72328362
82FES0.72122984
83ZAP700.70707729
84IRAK20.70577687
85GRK60.67628816
86PTK20.66853566
87NTRK10.66661056
88WNK10.65863034
89PAK20.64849685
90CDK190.64187110
91CAMK40.64180069
92WNK30.63871465
93STK100.63064134
94KSR20.62805461
95CAMK10.61513927
96PAK60.61372811
97RPS6KA60.61187010
98CSF1R0.60880245
99DAPK30.60110210
100CSK0.59889390
101MOS0.59350949
102STK110.58681776
103BRAF0.56317154
104UHMK10.56021119
105IRAK40.55461154
106MAPK120.55369550
107CDK60.55155285
108CDC42BPA0.54721621
109MAP2K40.52367500
110ILK0.52223731
111NTRK30.52186098
112ITK0.50345068
113PAK40.50204560
114MAP2K20.49913054
115FGFR30.49391887
116MAP3K130.49038315
117HCK0.48444493
118FGFR20.47715826
119SIK30.47447411
120MAP3K20.46742761
121MAP2K60.46711761
122GSK3A0.46126193
123CSNK1A1L0.46001932
124RPS6KA20.45293831
125CDK40.44190788
126BLK0.44075930
127ABL20.42856638
128PDGFRB0.42763802
129TESK20.41484344
130IKBKE0.41259063
131MAPK70.39870492
132ERBB20.39514286
133CDK11A0.38938964
134CSNK1G10.38546952
135MAPK40.36383423
136MST1R0.35521166
137LIMK10.35459194
138MAP3K80.35160816
139MAP3K140.34699074
140PRKG20.34473534
141CDK150.34132693

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.74227744
2Other glycan degradation_Homo sapiens_hsa005113.37836469
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.88781214
4Arginine biosynthesis_Homo sapiens_hsa002202.69215954
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.66779232
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.27006127
7Sulfur relay system_Homo sapiens_hsa041222.26013322
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09184813
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.04808561
10Fatty acid degradation_Homo sapiens_hsa000712.01294228
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.98120385
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79447601
13Tryptophan metabolism_Homo sapiens_hsa003801.76941943
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72443537
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61126794
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60410066
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58892847
18Bile secretion_Homo sapiens_hsa049761.57297492
19PPAR signaling pathway_Homo sapiens_hsa033201.55494995
20Lysine degradation_Homo sapiens_hsa003101.52079594
21Butanoate metabolism_Homo sapiens_hsa006501.51622332
22Fatty acid metabolism_Homo sapiens_hsa012121.47087880
23Complement and coagulation cascades_Homo sapiens_hsa046101.37001340
24Pancreatic cancer_Homo sapiens_hsa052121.35290066
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33829442
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28844359
27Endometrial cancer_Homo sapiens_hsa052131.25039451
28Lysosome_Homo sapiens_hsa041421.23507135
29Propanoate metabolism_Homo sapiens_hsa006401.21859673
30ErbB signaling pathway_Homo sapiens_hsa040121.21382028
31Insulin resistance_Homo sapiens_hsa049311.18757351
32Renal cell carcinoma_Homo sapiens_hsa052111.13096907
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10510664
34ABC transporters_Homo sapiens_hsa020101.08702275
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.05048591
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04033903
37B cell receptor signaling pathway_Homo sapiens_hsa046621.01260703
38Focal adhesion_Homo sapiens_hsa045100.99892318
39Ribosome_Homo sapiens_hsa030100.97732775
40Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96881612
41Staphylococcus aureus infection_Homo sapiens_hsa051500.96390670
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94758017
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93480579
44Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92974018
45Thyroid cancer_Homo sapiens_hsa052160.90414728
46beta-Alanine metabolism_Homo sapiens_hsa004100.90323195
47Peroxisome_Homo sapiens_hsa041460.89558901
48Leishmaniasis_Homo sapiens_hsa051400.88976934
49Fructose and mannose metabolism_Homo sapiens_hsa000510.88194904
50Acute myeloid leukemia_Homo sapiens_hsa052210.87987916
51Choline metabolism in cancer_Homo sapiens_hsa052310.87845626
52Fat digestion and absorption_Homo sapiens_hsa049750.87210553
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86352192
54Hepatitis C_Homo sapiens_hsa051600.86323677
55Chronic myeloid leukemia_Homo sapiens_hsa052200.85989282
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84886373
57Insulin signaling pathway_Homo sapiens_hsa049100.84632468
58Biosynthesis of amino acids_Homo sapiens_hsa012300.84374422
59Starch and sucrose metabolism_Homo sapiens_hsa005000.81335192
60TNF signaling pathway_Homo sapiens_hsa046680.81240122
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81098331
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80921782
63Axon guidance_Homo sapiens_hsa043600.79553478
64Caffeine metabolism_Homo sapiens_hsa002320.79202606
65Salmonella infection_Homo sapiens_hsa051320.78947470
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78494434
67Melanogenesis_Homo sapiens_hsa049160.78130335
68Synaptic vesicle cycle_Homo sapiens_hsa047210.77520467
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.77403969
70Carbon metabolism_Homo sapiens_hsa012000.77206276
71ECM-receptor interaction_Homo sapiens_hsa045120.77170003
72Hepatitis B_Homo sapiens_hsa051610.77132054
73Vibrio cholerae infection_Homo sapiens_hsa051100.76565368
74Type II diabetes mellitus_Homo sapiens_hsa049300.76186075
75Long-term potentiation_Homo sapiens_hsa047200.75599837
76Prion diseases_Homo sapiens_hsa050200.75522461
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74569436
78Histidine metabolism_Homo sapiens_hsa003400.74189250
79Toxoplasmosis_Homo sapiens_hsa051450.73924311
80Selenocompound metabolism_Homo sapiens_hsa004500.73689156
81Colorectal cancer_Homo sapiens_hsa052100.73269101
82Notch signaling pathway_Homo sapiens_hsa043300.73180092
83Pertussis_Homo sapiens_hsa051330.73092304
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.72611314
85Dorso-ventral axis formation_Homo sapiens_hsa043200.72269350
86MAPK signaling pathway_Homo sapiens_hsa040100.72185379
87VEGF signaling pathway_Homo sapiens_hsa043700.71847536
88Malaria_Homo sapiens_hsa051440.71269170
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.70371280
90Pyruvate metabolism_Homo sapiens_hsa006200.70043345
91Non-small cell lung cancer_Homo sapiens_hsa052230.68859944
92Basal cell carcinoma_Homo sapiens_hsa052170.68244776
93Estrogen signaling pathway_Homo sapiens_hsa049150.68176267
94Apoptosis_Homo sapiens_hsa042100.67847699
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67614977
96Glucagon signaling pathway_Homo sapiens_hsa049220.66785622
97Galactose metabolism_Homo sapiens_hsa000520.65958252
98Tuberculosis_Homo sapiens_hsa051520.65669553
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65367192
100Inositol phosphate metabolism_Homo sapiens_hsa005620.64854208
101Insulin secretion_Homo sapiens_hsa049110.64394863
102mTOR signaling pathway_Homo sapiens_hsa041500.64357842
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.63644332
104HTLV-I infection_Homo sapiens_hsa051660.63174475
105Prostate cancer_Homo sapiens_hsa052150.63013701
106Bladder cancer_Homo sapiens_hsa052190.62563929
107Influenza A_Homo sapiens_hsa051640.62472170
108Rap1 signaling pathway_Homo sapiens_hsa040150.61589617
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61559551
110AMPK signaling pathway_Homo sapiens_hsa041520.61370667
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.61367790
112Glycerolipid metabolism_Homo sapiens_hsa005610.61211742
113Fatty acid biosynthesis_Homo sapiens_hsa000610.61128341
114MicroRNAs in cancer_Homo sapiens_hsa052060.61104848
115Small cell lung cancer_Homo sapiens_hsa052220.59710527
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58442955
117Gastric acid secretion_Homo sapiens_hsa049710.58039178
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56696287
119Glioma_Homo sapiens_hsa052140.55826929
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55823400
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.54446528
122Gap junction_Homo sapiens_hsa045400.53008254
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50984970
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.50762829
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50642246
126HIF-1 signaling pathway_Homo sapiens_hsa040660.50526609
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.50512826
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.50386749
129T cell receptor signaling pathway_Homo sapiens_hsa046600.49797075
130Chemokine signaling pathway_Homo sapiens_hsa040620.49624059
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49594716
132Shigellosis_Homo sapiens_hsa051310.48726407
133Osteoclast differentiation_Homo sapiens_hsa043800.45865133
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45163972
135Folate biosynthesis_Homo sapiens_hsa007900.43610184
136Cocaine addiction_Homo sapiens_hsa050300.43168973
137Arginine and proline metabolism_Homo sapiens_hsa003300.43110118
138GnRH signaling pathway_Homo sapiens_hsa049120.43064263
139Amoebiasis_Homo sapiens_hsa051460.42928145
140Thyroid hormone synthesis_Homo sapiens_hsa049180.41739436
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41701905
142Proteoglycans in cancer_Homo sapiens_hsa052050.40045895
143Prolactin signaling pathway_Homo sapiens_hsa049170.39583457
144Endocytosis_Homo sapiens_hsa041440.38931413
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38492080
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.38117201
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38044127
148Dilated cardiomyopathy_Homo sapiens_hsa054140.36340794
149Platelet activation_Homo sapiens_hsa046110.35228109
150Phenylalanine metabolism_Homo sapiens_hsa003600.35189870
151cAMP signaling pathway_Homo sapiens_hsa040240.34656309
152Pentose phosphate pathway_Homo sapiens_hsa000300.34237185
153Renin secretion_Homo sapiens_hsa049240.34065708

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