RIOK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.01134547
2attachment of spindle microtubules to kinetochore (GO:0008608)4.80869754
3protein localization to kinetochore (GO:0034501)4.64098946
4proteasome assembly (GO:0043248)4.55698544
5mitotic chromosome condensation (GO:0007076)4.53853394
6CENP-A containing nucleosome assembly (GO:0034080)4.51663070
7metaphase plate congression (GO:0051310)4.48138502
8kinetochore organization (GO:0051383)4.34832848
9chromatin remodeling at centromere (GO:0031055)4.32893370
10DNA replication checkpoint (GO:0000076)4.27416547
11establishment of chromosome localization (GO:0051303)4.23480293
12meiotic chromosome segregation (GO:0045132)4.05036021
13protein localization to chromosome, centromeric region (GO:0071459)4.01610451
14DNA replication-independent nucleosome organization (GO:0034724)4.00365626
15DNA replication-independent nucleosome assembly (GO:0006336)4.00365626
16ribosome assembly (GO:0042255)3.96342066
17DNA replication initiation (GO:0006270)3.87921544
18DNA strand elongation involved in DNA replication (GO:0006271)3.86737883
19kinetochore assembly (GO:0051382)3.85294368
20formation of translation preinitiation complex (GO:0001731)3.79734302
21regulation of spindle organization (GO:0090224)3.78351892
22telomere maintenance via semi-conservative replication (GO:0032201)3.76544989
23mitotic sister chromatid segregation (GO:0000070)3.76225428
24DNA strand elongation (GO:0022616)3.75011384
25mitotic nuclear envelope disassembly (GO:0007077)3.68262891
26histone exchange (GO:0043486)3.68246085
27telomere maintenance via recombination (GO:0000722)3.62248244
28ribosomal large subunit biogenesis (GO:0042273)3.57394241
29ribosomal small subunit assembly (GO:0000028)3.57215280
30pseudouridine synthesis (GO:0001522)3.55979472
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.53256634
32DNA damage response, detection of DNA damage (GO:0042769)3.53203535
33rRNA processing (GO:0006364)3.53106545
34maturation of 5.8S rRNA (GO:0000460)3.52509963
35mitotic recombination (GO:0006312)3.47394418
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46187801
37establishment of integrated proviral latency (GO:0075713)3.45134167
38rRNA metabolic process (GO:0016072)3.43190820
39ribosome biogenesis (GO:0042254)3.42862282
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42657571
41nuclear envelope disassembly (GO:0051081)3.41091976
42membrane disassembly (GO:0030397)3.41091976
43sister chromatid segregation (GO:0000819)3.40757001
44mitotic sister chromatid cohesion (GO:0007064)3.37582116
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.35039090
46DNA double-strand break processing (GO:0000729)3.34151976
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.33539372
48spliceosomal snRNP assembly (GO:0000387)3.32140244
49regulation of mitotic spindle organization (GO:0060236)3.31055680
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.30949705
51telomere maintenance via telomere lengthening (GO:0010833)3.30666840
52chromosome segregation (GO:0007059)3.30047121
53spindle checkpoint (GO:0031577)3.29304982
54synapsis (GO:0007129)3.28810981
55nuclear pore complex assembly (GO:0051292)3.26824258
56ribonucleoprotein complex biogenesis (GO:0022613)3.25610629
57viral mRNA export from host cell nucleus (GO:0046784)3.23738459
58DNA catabolic process, exonucleolytic (GO:0000738)3.23724907
59DNA unwinding involved in DNA replication (GO:0006268)3.22965704
60protein K6-linked ubiquitination (GO:0085020)3.22566076
61regulation of DNA endoreduplication (GO:0032875)3.21921461
62negative regulation of ligase activity (GO:0051352)3.21661349
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21661349
64regulation of meiosis I (GO:0060631)3.21490196
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20957179
66maturation of SSU-rRNA (GO:0030490)3.20463780
67positive regulation of histone H3-K4 methylation (GO:0051571)3.18532418
68regulation of female gonad development (GO:2000194)3.18436612
69regulation of centriole replication (GO:0046599)3.18288830
70tRNA aminoacylation for protein translation (GO:0006418)3.18063871
71centriole replication (GO:0007099)3.17149331
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.16793606
73tRNA aminoacylation (GO:0043039)3.16136123
74amino acid activation (GO:0043038)3.16136123
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15763034
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15763034
77termination of RNA polymerase III transcription (GO:0006386)3.15291240
78transcription elongation from RNA polymerase III promoter (GO:0006385)3.15291240
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12883564
80protein localization to chromosome (GO:0034502)3.12567373
81regulation of helicase activity (GO:0051095)3.10601728
82non-recombinational repair (GO:0000726)3.09111150
83double-strand break repair via nonhomologous end joining (GO:0006303)3.09111150
84DNA ligation (GO:0006266)3.08881208
85histone mRNA metabolic process (GO:0008334)3.07150288
86DNA methylation involved in gamete generation (GO:0043046)3.07093919
87mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06726108
88cullin deneddylation (GO:0010388)3.05933440
89nuclear pore organization (GO:0006999)3.05663105
90mitochondrial RNA metabolic process (GO:0000959)3.05560917
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05206203
92chromatin assembly or disassembly (GO:0006333)3.04931240
93positive regulation of chromosome segregation (GO:0051984)3.04605920
94ncRNA metabolic process (GO:0034660)3.03784975
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03281040
96mitotic spindle checkpoint (GO:0071174)3.02965561
97negative regulation of mitotic sister chromatid separation (GO:2000816)3.02162956
98negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02162956
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02162956
100negative regulation of sister chromatid segregation (GO:0033046)3.02162956
101regulation of mitochondrial translation (GO:0070129)3.02036952
102negative regulation of chromosome segregation (GO:0051985)2.99833804
103DNA topological change (GO:0006265)2.98986505
104spindle assembly checkpoint (GO:0071173)2.98810003
105regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98272332
106maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.97295509
107meiotic cell cycle (GO:0051321)2.97243166
108resolution of meiotic recombination intermediates (GO:0000712)2.95415137
109regulation of chromosome segregation (GO:0051983)2.95173065
110sister chromatid cohesion (GO:0007062)2.94863498
111DNA replication-dependent nucleosome assembly (GO:0006335)2.93560428
112DNA replication-dependent nucleosome organization (GO:0034723)2.93560428
113mitotic spindle assembly checkpoint (GO:0007094)2.93288351
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92987311
115transcription elongation from RNA polymerase I promoter (GO:0006362)2.92609614
116cellular component biogenesis (GO:0044085)2.92153600
117exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91083146
118postreplication repair (GO:0006301)2.90309521
119replication fork processing (GO:0031297)2.88904802
120monoubiquitinated protein deubiquitination (GO:0035520)2.88788425
121histone H2A monoubiquitination (GO:0035518)2.88648826
122tRNA metabolic process (GO:0006399)2.88279694
123ncRNA processing (GO:0034470)2.87863078
124rRNA modification (GO:0000154)2.87861520
125protein deneddylation (GO:0000338)2.87620780
126IMP biosynthetic process (GO:0006188)2.87474270
127negative regulation of meiosis (GO:0045835)2.86010429
128regulation of sister chromatid segregation (GO:0033045)2.85084154
129regulation of mitotic sister chromatid separation (GO:0010965)2.85084154
130regulation of mitotic sister chromatid segregation (GO:0033047)2.85084154
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.84035311
132nucleobase biosynthetic process (GO:0046112)2.83650522
133telomere maintenance via telomerase (GO:0007004)2.83027249
134mismatch repair (GO:0006298)2.82091937
135ATP-dependent chromatin remodeling (GO:0043044)2.81795303
136regulation of double-strand break repair via homologous recombination (GO:0010569)2.81529807
137rRNA methylation (GO:0031167)2.79330012
138nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78348778
139piRNA metabolic process (GO:0034587)2.77388906
140IMP metabolic process (GO:0046040)2.76829445
141telomere maintenance (GO:0000723)2.75913318
142negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.75833801
143negative regulation of DNA-templated transcription, elongation (GO:0032785)2.75833801
144RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75077558
145telomere organization (GO:0032200)2.72967521
146female gamete generation (GO:0007292)2.69961837
147regulation of mitotic spindle checkpoint (GO:1903504)2.69037865
148regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69037865
149regulation of sister chromatid cohesion (GO:0007063)2.68670264
150base-excision repair, AP site formation (GO:0006285)2.66931154
151mitotic cell cycle (GO:0000278)2.65741403
152transcription-coupled nucleotide-excision repair (GO:0006283)2.65597515
153nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.64692198
154purine nucleobase biosynthetic process (GO:0009113)2.64595870
155folic acid-containing compound biosynthetic process (GO:0009396)2.64246802
156nuclear envelope organization (GO:0006998)2.63812812
157regulation of nuclear cell cycle DNA replication (GO:0033262)2.63376516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.26510005
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.98599561
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21497267
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.96457286
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.52544963
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19666388
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.85662142
8* GABP_17652178_ChIP-ChIP_JURKAT_Human2.79836061
9AR_21909140_ChIP-Seq_LNCAP_Human2.47291519
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40304537
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34569442
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31049928
13VDR_23849224_ChIP-Seq_CD4+_Human2.28433636
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.28263726
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.26312506
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23212722
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16829581
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15712695
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15466238
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14270118
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11369682
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05867165
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02195422
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01430406
25FOXP3_21729870_ChIP-Seq_TREG_Human2.00718363
26* ELK1_19687146_ChIP-ChIP_HELA_Human1.96276685
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93098629
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91484255
29* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88777406
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86892912
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86146816
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81894895
33* DCP1A_22483619_ChIP-Seq_HELA_Human1.79812515
34XRN2_22483619_ChIP-Seq_HELA_Human1.79625799
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.79201603
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76551385
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.76401445
38CIITA_25753668_ChIP-Seq_RAJI_Human1.70628394
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70094923
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68713215
41* GABP_19822575_ChIP-Seq_HepG2_Human1.66484016
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.65827504
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64888167
44TTF2_22483619_ChIP-Seq_HELA_Human1.62009010
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59135202
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56115820
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51310247
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50806799
49* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48679686
50MYC_22102868_ChIP-Seq_BL_Human1.47968173
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47748484
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.44774697
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.44005147
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43849321
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39031442
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39030883
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37313074
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35777655
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35121994
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34651772
61MYC_18940864_ChIP-ChIP_HL60_Human1.33122549
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31302814
63KDM5A_27292631_Chip-Seq_BREAST_Human1.30113831
64SPI1_23547873_ChIP-Seq_NB4_Human1.28292810
65ZNF274_21170338_ChIP-Seq_K562_Hela1.24783869
66FUS_26573619_Chip-Seq_HEK293_Human1.24640681
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24191863
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23259821
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19924848
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19735036
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19668378
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18860477
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16341497
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13087162
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08451546
76VDR_22108803_ChIP-Seq_LS180_Human1.05662137
77MYB_26560356_Chip-Seq_TH2_Human1.01939641
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01140850
79IRF8_21731497_ChIP-ChIP_J774_Mouse0.99979594
80MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95732186
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94440618
82IRF8_22096565_ChIP-ChIP_GC-B_Human0.94007757
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93685270
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91787307
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91117310
86MYB_26560356_Chip-Seq_TH1_Human0.90742034
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.90654421
88IGF1R_20145208_ChIP-Seq_DFB_Human0.89179063
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88699104
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88583930
91EWS_26573619_Chip-Seq_HEK293_Human0.88296127
92TFEB_21752829_ChIP-Seq_HELA_Human0.86642567
93* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86531459
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86003255
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85865651
96KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85210513
97BP1_19119308_ChIP-ChIP_Hs578T_Human0.84990203
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84641584
99* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84372073
100TP53_22573176_ChIP-Seq_HFKS_Human0.83358832
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83165830
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83036160
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82034291
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82034291
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82034291
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79937879
107IRF1_19129219_ChIP-ChIP_H3396_Human0.79203454
108POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77850918
109FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.77289620
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.76949454
111ELK1_22589737_ChIP-Seq_MCF10A_Human0.76691720
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75132353
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74868614
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.74009376
115* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72728484
116FLI1_27457419_Chip-Seq_LIVER_Mouse0.70956717
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.70537792
118TAF15_26573619_Chip-Seq_HEK293_Human0.70346039
119SOX2_18555785_ChIP-Seq_MESCs_Mouse0.68996834
120ELF5_23300383_ChIP-Seq_T47D_Human0.68728360
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.68669393
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67938439
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67614377
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.65366994

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.68370773
2MP0010094_abnormal_chromosome_stability4.53754263
3MP0003111_abnormal_nucleus_morphology3.90773068
4MP0003077_abnormal_cell_cycle3.74426824
5MP0004957_abnormal_blastocyst_morpholog3.57269455
6MP0008057_abnormal_DNA_replication3.48595921
7MP0002396_abnormal_hematopoietic_system2.90389329
8MP0008058_abnormal_DNA_repair2.86103350
9MP0008877_abnormal_DNA_methylation2.78441682
10MP0008007_abnormal_cellular_replicative2.75628317
11MP0003718_maternal_effect2.74286015
12MP0003763_abnormal_thymus_physiology2.42655508
13MP0008932_abnormal_embryonic_tissue2.20286403
14MP0004147_increased_porphyrin_level2.05066552
15MP0008789_abnormal_olfactory_epithelium2.03837773
16MP0003123_paternal_imprinting2.01034231
17MP0003890_abnormal_embryonic-extraembry1.94323250
18MP0000490_abnormal_crypts_of1.86463885
19MP0000350_abnormal_cell_proliferation1.83401039
20MP0004808_abnormal_hematopoietic_stem1.75628031
21MP0006292_abnormal_olfactory_placode1.71547258
22MP0003121_genomic_imprinting1.69728929
23MP0001119_abnormal_female_reproductive1.66492605
24MP0001293_anophthalmia1.64484199
25MP0002398_abnormal_bone_marrow1.60821053
26MP0009333_abnormal_splenocyte_physiolog1.59319197
27MP0002019_abnormal_tumor_incidence1.54479405
28MP0002160_abnormal_reproductive_system1.49811952
29MP0005499_abnormal_olfactory_system1.49800427
30MP0005394_taste/olfaction_phenotype1.49800427
31MP0003786_premature_aging1.49055067
32MP0010307_abnormal_tumor_latency1.48504076
33MP0000465_gastrointestinal_hemorrhage1.47600599
34MP0005671_abnormal_response_to1.47562610
35MP0003186_abnormal_redox_activity1.46872837
36MP0006036_abnormal_mitochondrial_physio1.46341766
37MP0000703_abnormal_thymus_morphology1.45506331
38MP0006035_abnormal_mitochondrial_morpho1.44740674
39MP0001730_embryonic_growth_arrest1.42910811
40MP0001835_abnormal_antigen_presentation1.40847769
41MP0005451_abnormal_body_composition1.39125051
42MP0000689_abnormal_spleen_morphology1.39078923
43MP0002210_abnormal_sex_determination1.37204704
44MP0002722_abnormal_immune_system1.34313973
45MP0005397_hematopoietic_system_phenotyp1.33988060
46MP0001545_abnormal_hematopoietic_system1.33988060
47MP0001800_abnormal_humoral_immune1.33244926
48MP0003806_abnormal_nucleotide_metabolis1.30307004
49MP0001929_abnormal_gametogenesis1.29245703
50MP0001697_abnormal_embryo_size1.27505346
51MP0006072_abnormal_retinal_apoptosis1.26874958
52MP0000653_abnormal_sex_gland1.26658111
53MP0000313_abnormal_cell_death1.26568204
54MP0001188_hyperpigmentation1.25919063
55MP0006054_spinal_hemorrhage1.25810689
56MP0001672_abnormal_embryogenesis/_devel1.25684701
57MP0005380_embryogenesis_phenotype1.25684701
58MP0003787_abnormal_imprinting1.25493796
59MP0002102_abnormal_ear_morphology1.24279150
60MP0002420_abnormal_adaptive_immunity1.23735215
61MP0002452_abnormal_antigen_presenting1.22945591
62MP0001819_abnormal_immune_cell1.21805316
63MP0000716_abnormal_immune_system1.18557681
64MP0008995_early_reproductive_senescence1.17251017
65MP0003699_abnormal_female_reproductive1.17121301
66MP0009697_abnormal_copulation1.16720461
67MP0002429_abnormal_blood_cell1.16176950
68MP0003698_abnormal_male_reproductive1.13709838
69MP0000858_altered_metastatic_potential1.12509737
70MP0010352_gastrointestinal_tract_polyps1.09889015
71MP0002723_abnormal_immune_serum1.09147259
72MP0002085_abnormal_embryonic_tissue1.07582684
73MP0003984_embryonic_growth_retardation1.05516774
74MP0001145_abnormal_male_reproductive1.03799311
75MP0005408_hypopigmentation1.02450845
76MP0002132_abnormal_respiratory_system1.01978966
77MP0002088_abnormal_embryonic_growth/wei1.01928259
78MP0002080_prenatal_lethality1.01676572
79MP0001915_intracranial_hemorrhage1.00756597
80MP0000685_abnormal_immune_system1.00554000
81MP0001764_abnormal_homeostasis1.00040255
82MP0002405_respiratory_system_inflammati0.98570991
83MP0002006_tumorigenesis0.96616128
84MP0000358_abnormal_cell_content/0.96359458
85MP0002234_abnormal_pharynx_morphology0.95075286
86MP0002086_abnormal_extraembryonic_tissu0.95044672
87MP0001529_abnormal_vocalization0.94046687
88MP0005000_abnormal_immune_tolerance0.93603620
89MP0002277_abnormal_respiratory_mucosa0.93363119
90MP0009785_altered_susceptibility_to0.90610812
91MP0005395_other_phenotype0.90329174
92MP0009379_abnormal_foot_pigmentation0.89419644
93MP0003937_abnormal_limbs/digits/tail_de0.89092559
94MP0005410_abnormal_fertilization0.88619024
95MP0002084_abnormal_developmental_patter0.88115568
96MP0003315_abnormal_perineum_morphology0.86404582
97MP0002233_abnormal_nose_morphology0.83996276
98MP0000631_abnormal_neuroendocrine_gland0.83788244
99MP0003136_yellow_coat_color0.82781581
100MP0004142_abnormal_muscle_tone0.81604145
101MP0001286_abnormal_eye_development0.81284815
102MP0003567_abnormal_fetal_cardiomyocyte0.80534132
103MP0000049_abnormal_middle_ear0.80411017
104MP0002419_abnormal_innate_immunity0.79221958
105MP0001919_abnormal_reproductive_system0.77557021
106MP0001873_stomach_inflammation0.77324139
107MP0010155_abnormal_intestine_physiology0.75938683
108MP0005389_reproductive_system_phenotype0.75767425
109MP0005025_abnormal_response_to0.73479978
110MP0005621_abnormal_cell_physiology0.72735212
111MP0001853_heart_inflammation0.72734212
112MP0001790_abnormal_immune_system0.72399970
113MP0005387_immune_system_phenotype0.72399970
114MP0002138_abnormal_hepatobiliary_system0.72195108
115MP0002933_joint_inflammation0.71721762
116MP0002009_preneoplasia0.70718522
117MP0003943_abnormal_hepatobiliary_system0.70345597
118MP0003436_decreased_susceptibility_to0.69217870
119MP0003656_abnormal_erythrocyte_physiolo0.68914554
120MP0005075_abnormal_melanosome_morpholog0.68447550
121MP0005384_cellular_phenotype0.68359225
122MP0005360_urolithiasis0.67912115
123MP0001727_abnormal_embryo_implantation0.64751296
124MP0002095_abnormal_skin_pigmentation0.64469299
125MP0004197_abnormal_fetal_growth/weight/0.63859765
126MP0003646_muscle_fatigue0.63748224
127MP0005174_abnormal_tail_pigmentation0.63581107
128MP0005464_abnormal_platelet_physiology0.62945326
129MP0003448_altered_tumor_morphology0.62620172
130MP0000015_abnormal_ear_pigmentation0.62086566
131MP0004782_abnormal_surfactant_physiolog0.61867733
132MP0002938_white_spotting0.60965920
133MP0002177_abnormal_outer_ear0.60732606
134MP0000372_irregular_coat_pigmentation0.59180390
135MP0002161_abnormal_fertility/fecundity0.59021255
136MP0005023_abnormal_wound_healing0.58115872
137MP0002751_abnormal_autonomic_nervous0.57997194
138MP0003941_abnormal_skin_development0.57262696
139MP0002163_abnormal_gland_morphology0.56709858
140MP0005646_abnormal_pituitary_gland0.55858977
141MP0003755_abnormal_palate_morphology0.54258743
142MP0005253_abnormal_eye_physiology0.53795881
143MP0001324_abnormal_eye_pigmentation0.52876773
144MP0009672_abnormal_birth_weight0.52182210
145MP0009703_decreased_birth_body0.51499513
146MP0002111_abnormal_tail_morphology0.50342531
147MP0005551_abnormal_eye_electrophysiolog0.48203813

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.45664060
2Chromsome breakage (HP:0040012)4.87799881
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.25539570
4Increased hepatocellular lipid droplets (HP:0006565)3.97637872
5Breast hypoplasia (HP:0003187)3.56432346
6Patellar aplasia (HP:0006443)3.48047935
7Lipid accumulation in hepatocytes (HP:0006561)3.46009129
8Acute necrotizing encephalopathy (HP:0006965)3.41885014
9Abnormality of chromosome stability (HP:0003220)3.35740163
10Aplastic anemia (HP:0001915)3.32203909
11Increased CSF lactate (HP:0002490)3.21551638
12Aplasia/Hypoplasia of the patella (HP:0006498)3.18085848
13Acute encephalopathy (HP:0006846)3.09202874
14Myelodysplasia (HP:0002863)3.05879323
15Abnormal mitochondria in muscle tissue (HP:0008316)3.04904835
16Mitochondrial inheritance (HP:0001427)3.04301594
17Renal Fanconi syndrome (HP:0001994)3.01998354
18Abnormality of the preputium (HP:0100587)2.96460831
19Reticulocytopenia (HP:0001896)2.91729044
20Microvesicular hepatic steatosis (HP:0001414)2.83418579
21Meckel diverticulum (HP:0002245)2.82531146
22Progressive macrocephaly (HP:0004481)2.81577666
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71369197
24Increased serum lactate (HP:0002151)2.70754560
25Irregular epiphyses (HP:0010582)2.69870939
26Abnormality of the ileum (HP:0001549)2.68485022
27Type I transferrin isoform profile (HP:0003642)2.66780912
28Cerebral hypomyelination (HP:0006808)2.66346551
29Hepatic necrosis (HP:0002605)2.62105085
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.61906232
31Flat capital femoral epiphysis (HP:0003370)2.57730854
32Small intestinal stenosis (HP:0012848)2.57278815
33Duodenal stenosis (HP:0100867)2.57278815
34Hepatocellular necrosis (HP:0001404)2.56762879
35Abnormality of the pons (HP:0007361)2.54277426
36Sensory axonal neuropathy (HP:0003390)2.52936775
37Acute myeloid leukemia (HP:0004808)2.46861290
38Abnormal lung lobation (HP:0002101)2.46511869
39Male infertility (HP:0003251)2.45787245
40Premature ovarian failure (HP:0008209)2.45773570
41Facial hemangioma (HP:0000329)2.43398354
42Sloping forehead (HP:0000340)2.42802816
43IgM deficiency (HP:0002850)2.42447562
44Exertional dyspnea (HP:0002875)2.41203466
45Type 2 muscle fiber atrophy (HP:0003554)2.39383690
46Increased intramyocellular lipid droplets (HP:0012240)2.39330960
47Abnormal number of erythroid precursors (HP:0012131)2.39257215
48Methylmalonic acidemia (HP:0002912)2.37801657
49Abnormality of cells of the erythroid lineage (HP:0012130)2.36226321
50Abnormality of methionine metabolism (HP:0010901)2.35375675
51Myositis (HP:0100614)2.34439908
52Bone marrow hypocellularity (HP:0005528)2.33788797
53Renal cortical cysts (HP:0000803)2.33576443
54Macrocytic anemia (HP:0001972)2.32901657
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32070147
56Abnormal protein N-linked glycosylation (HP:0012347)2.32070147
57Abnormal protein glycosylation (HP:0012346)2.32070147
58Abnormal glycosylation (HP:0012345)2.32070147
59Cerebral edema (HP:0002181)2.31817351
60Carpal bone hypoplasia (HP:0001498)2.31779728
61Ectopic kidney (HP:0000086)2.31209477
62Hypoplasia of the pons (HP:0012110)2.31167866
63Oral leukoplakia (HP:0002745)2.30707243
64Pulmonary fibrosis (HP:0002206)2.27603292
65Clubbing of toes (HP:0100760)2.27338062
66Combined immunodeficiency (HP:0005387)2.27291994
67Muscle fiber atrophy (HP:0100295)2.25254780
68Abnormality of the fingertips (HP:0001211)2.23068713
69Thrombocytosis (HP:0001894)2.21882927
70Increased serum pyruvate (HP:0003542)2.21596729
71Respiratory difficulties (HP:0002880)2.21116263
72Pancytopenia (HP:0001876)2.19221520
73Medulloblastoma (HP:0002885)2.15906228
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15447846
75Capillary hemangiomas (HP:0005306)2.14850012
7611 pairs of ribs (HP:0000878)2.14722421
77Abnormality of the labia minora (HP:0012880)2.13768598
78Optic neuritis (HP:0100653)2.12112241
79Retrobulbar optic neuritis (HP:0100654)2.12112241
80Lactic acidosis (HP:0003128)2.11942212
81Volvulus (HP:0002580)2.11550292
82Rhabdomyosarcoma (HP:0002859)2.11152669
83Nephroblastoma (Wilms tumor) (HP:0002667)2.10531453
84Abnormality of the anterior horn cell (HP:0006802)2.10466055
85Degeneration of anterior horn cells (HP:0002398)2.10466055
86Absent radius (HP:0003974)2.09773652
87Aplasia/Hypoplasia of the sternum (HP:0006714)2.09372038
88Lymphoma (HP:0002665)2.08917162
89Reduced antithrombin III activity (HP:0001976)2.07576427
90Abnormality of renal resorption (HP:0011038)2.06125798
91Hypergonadotropic hypogonadism (HP:0000815)2.06107786
92Agnosia (HP:0010524)2.04297485
93Secondary amenorrhea (HP:0000869)2.03983220
94Pancreatic cysts (HP:0001737)2.02056025
95Abnormality of alanine metabolism (HP:0010916)2.01353303
96Hyperalaninemia (HP:0003348)2.01353303
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01353303
98Abnormality of the duodenum (HP:0002246)2.00982581
99Supernumerary spleens (HP:0009799)2.00914596
100Abnormality of the prostate (HP:0008775)1.99123195
101Megaloblastic anemia (HP:0001889)1.98328820
102Abnormality of the renal collecting system (HP:0004742)1.97679519
103Overlapping toe (HP:0001845)1.97293033
104Duplicated collecting system (HP:0000081)1.97135445
105Short thumb (HP:0009778)1.96672440
106Abnormality of glycolysis (HP:0004366)1.96226102
107Colon cancer (HP:0003003)1.94651630
108IgG deficiency (HP:0004315)1.93266821
109Abnormality of DNA repair (HP:0003254)1.93266318
110Adrenal hypoplasia (HP:0000835)1.93175680
111Premature graying of hair (HP:0002216)1.93145599
112Exercise intolerance (HP:0003546)1.93120259
113Aplasia involving forearm bones (HP:0009822)1.93017438
114Absent forearm bone (HP:0003953)1.93017438
1153-Methylglutaconic aciduria (HP:0003535)1.92728828
116Embryonal renal neoplasm (HP:0011794)1.92577969
117Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90196258
118Generalized aminoaciduria (HP:0002909)1.89911546
119Multiple enchondromatosis (HP:0005701)1.89769143
120B lymphocytopenia (HP:0010976)1.87753882
121Abnormality of B cell number (HP:0010975)1.87753882
122Slender long bone (HP:0003100)1.87625907
123Methylmalonic aciduria (HP:0012120)1.87242536
124Severe combined immunodeficiency (HP:0004430)1.85430491
125Molar tooth sign on MRI (HP:0002419)1.84223242
126Abnormality of midbrain morphology (HP:0002418)1.84223242
127Impulsivity (HP:0100710)1.83601498
128Rough bone trabeculation (HP:0100670)1.81984433
129Papillary thyroid carcinoma (HP:0002895)1.81735810
130Short middle phalanx of the 5th finger (HP:0004220)1.81075537
131Orchitis (HP:0100796)1.79218545
132Absent thumb (HP:0009777)1.77695332
133Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77301412
134Recurrent abscess formation (HP:0002722)1.76996828
135Selective tooth agenesis (HP:0001592)1.76618153
136Glycosuria (HP:0003076)1.76207461
137Abnormality of urine glucose concentration (HP:0011016)1.76207461
138Optic disc pallor (HP:0000543)1.76156176
139Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75791049
140Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75791049
141Pendular nystagmus (HP:0012043)1.75522182
142Increased muscle lipid content (HP:0009058)1.75052969
143Spondylolisthesis (HP:0003302)1.74979780
144Pancreatic fibrosis (HP:0100732)1.74855542
145Abnormality of the carotid arteries (HP:0005344)1.73957174
146Absent epiphyses (HP:0010577)1.72010148
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72010148
148Triphalangeal thumb (HP:0001199)1.71850891
149Horseshoe kidney (HP:0000085)1.71651521
150Abnormality of chromosome segregation (HP:0002916)1.70769714
151Deep philtrum (HP:0002002)1.70255361
152Cellular immunodeficiency (HP:0005374)1.70027607
153Optic nerve coloboma (HP:0000588)1.69181734
154Entropion (HP:0000621)1.68862864
155Hypoplastic iliac wings (HP:0002866)1.68200123
156Aseptic necrosis (HP:0010885)1.64716901
157Long clavicles (HP:0000890)1.63037437
158Pallor (HP:0000980)1.62812336
159Mediastinal lymphadenopathy (HP:0100721)1.62566633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.99785105
2PLK43.07824262
3EIF2AK12.88387600
4TTK2.79089144
5BUB12.78627593
6WEE12.74603292
7PBK2.53504151
8VRK22.47665463
9STK102.27555443
10SRPK12.24053447
11ACVR1B2.11484732
12TAOK32.09825223
13TRIM282.09451192
14BRSK22.08891357
15NEK22.07445164
16CDK81.98258712
17PLK11.97730160
18MAP3K61.94167139
19NME11.88159359
20TXK1.84592416
21BMPR21.76225956
22VRK11.73676608
23STK38L1.73103213
24MKNK11.71846373
25AURKB1.65108607
26TAF11.64156923
27MAP4K11.63516386
28MOS1.60905877
29PLK31.55034870
30CHEK21.53483210
31STK241.52649271
32MELK1.52481390
33TSSK61.52218226
34ATR1.48390795
35BRAF1.46595405
36MKNK21.45740395
37RPS6KA41.40628307
38MAP4K21.39912192
39MAP3K81.38125064
40EIF2AK31.36781703
41CCNB11.34147854
42EEF2K1.33438625
43CDK71.32751739
44JAK31.32378590
45LATS11.28993327
46TGFBR11.28446388
47RPS6KB21.27409852
48PNCK1.27384769
49MUSK1.23729484
50TEC1.22027242
51STK31.21823873
52PDK21.21262686
53PIM11.18704224
54NME21.18047461
55NUAK11.15612711
56NLK1.15607533
57ZAK1.14235625
58MAP3K121.10590937
59BRSK11.09223948
60NEK91.08112274
61ERBB41.07126559
62TNIK1.03141105
63KIT0.98322006
64CHEK10.98251010
65PASK0.93127569
66TLK10.90473129
67ATM0.90205959
68WNK30.89662326
69AURKA0.88185877
70IRAK40.87057717
71EIF2AK20.86721388
72RAF10.82573197
73STK40.82250446
74BTK0.79957506
75DYRK30.79422256
76CDK40.78436447
77MST40.77830865
78STK160.77806462
79CDK90.77138843
80CSNK1G10.75913421
81BCR0.68692778
82LATS20.67805440
83CHUK0.65906258
84CSNK1E0.63976263
85ALK0.63963580
86CDK20.63755664
87CSNK1G30.62781558
88BMPR1B0.60562956
89TRPM70.60334017
90ERBB30.60216543
91IKBKB0.59672620
92MAPKAPK50.58244477
93CDK10.57794173
94CDK190.57511266
95FLT30.57258736
96RPS6KA50.54592143
97CSNK1G20.53250081
98PLK20.53062399
99DMPK0.52450419
100MAP3K140.52023921
101CSF1R0.51062758
102PRKCI0.50962977
103MARK30.50422066
104ZAP700.48749306
105MAP3K90.47203966
106IKBKE0.46578449
107CLK10.45718766
108IRAK30.45707778
109DYRK20.44767008
110MAP3K130.44267805
111CSNK2A10.42894651
112YES10.42848608
113ITK0.42283680
114CDK30.42171967
115CDK120.41766613
116WNK40.41408431
117MAP3K50.41215099
118DAPK10.40690780
119LYN0.40363355
120NEK10.40330380
121CSNK1A1L0.40160718
122BCKDK0.40090466
123BRD40.37344906
124PIM20.35655845
125LCK0.34994291
126NEK60.33975772
127LRRK20.33723339
128EPHA30.31070267
129PRKDC0.30766389
130CSNK2A20.30622460
131SCYL20.29713085
132PRKACB0.25321388
133GRK10.24357652
134OXSR10.24260078
135STK390.23467790

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.17532156
2Mismatch repair_Homo sapiens_hsa034303.55972827
3Homologous recombination_Homo sapiens_hsa034403.18236679
4* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13159060
5Cell cycle_Homo sapiens_hsa041103.06120239
6Base excision repair_Homo sapiens_hsa034103.01481682
7RNA polymerase_Homo sapiens_hsa030202.73691785
8RNA degradation_Homo sapiens_hsa030182.72058685
9Basal transcription factors_Homo sapiens_hsa030222.63986656
10Nucleotide excision repair_Homo sapiens_hsa034202.62301405
11RNA transport_Homo sapiens_hsa030132.61660442
12Non-homologous end-joining_Homo sapiens_hsa034502.60140285
13Spliceosome_Homo sapiens_hsa030402.54370217
14Fanconi anemia pathway_Homo sapiens_hsa034602.52392623
15Ribosome_Homo sapiens_hsa030102.30213371
16Oxidative phosphorylation_Homo sapiens_hsa001902.09875797
17Proteasome_Homo sapiens_hsa030502.08531237
18Pyrimidine metabolism_Homo sapiens_hsa002402.05794039
19Parkinsons disease_Homo sapiens_hsa050121.87987278
20p53 signaling pathway_Homo sapiens_hsa041151.84703293
21One carbon pool by folate_Homo sapiens_hsa006701.65611584
22Huntingtons disease_Homo sapiens_hsa050161.60299956
23Selenocompound metabolism_Homo sapiens_hsa004501.46081120
24mRNA surveillance pathway_Homo sapiens_hsa030151.44759396
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38279452
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34462768
27Propanoate metabolism_Homo sapiens_hsa006401.33723176
28Primary immunodeficiency_Homo sapiens_hsa053401.31821775
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28871725
30Herpes simplex infection_Homo sapiens_hsa051681.28298625
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25395774
32Purine metabolism_Homo sapiens_hsa002301.21064955
33Antigen processing and presentation_Homo sapiens_hsa046121.19019242
34Epstein-Barr virus infection_Homo sapiens_hsa051691.16611268
35Oocyte meiosis_Homo sapiens_hsa041141.12526368
36Protein export_Homo sapiens_hsa030601.09549308
37Measles_Homo sapiens_hsa051621.08842845
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08812104
39Folate biosynthesis_Homo sapiens_hsa007901.05112285
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04954479
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.01345403
42Viral carcinogenesis_Homo sapiens_hsa052030.96619497
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96358599
44Alzheimers disease_Homo sapiens_hsa050100.95312669
45Fatty acid elongation_Homo sapiens_hsa000620.94612325
46Pyruvate metabolism_Homo sapiens_hsa006200.94196746
47Hematopoietic cell lineage_Homo sapiens_hsa046400.90116088
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89747391
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88035110
50HTLV-I infection_Homo sapiens_hsa051660.87667324
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86666278
52MicroRNAs in cancer_Homo sapiens_hsa052060.86196271
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84842800
54Systemic lupus erythematosus_Homo sapiens_hsa053220.83195281
55Thyroid cancer_Homo sapiens_hsa052160.82328533
56Leishmaniasis_Homo sapiens_hsa051400.81867313
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81209470
58Pancreatic cancer_Homo sapiens_hsa052120.79073721
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76485390
60Shigellosis_Homo sapiens_hsa051310.75385500
61Hepatitis B_Homo sapiens_hsa051610.74949214
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.74106513
63Small cell lung cancer_Homo sapiens_hsa052220.73317703
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73077505
65Sulfur relay system_Homo sapiens_hsa041220.72951460
66Allograft rejection_Homo sapiens_hsa053300.72838278
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72240718
68Steroid biosynthesis_Homo sapiens_hsa001000.71883035
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69933539
70Legionellosis_Homo sapiens_hsa051340.69753227
71Apoptosis_Homo sapiens_hsa042100.68469596
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68322257
73Graft-versus-host disease_Homo sapiens_hsa053320.67979262
74Other glycan degradation_Homo sapiens_hsa005110.66641173
75TGF-beta signaling pathway_Homo sapiens_hsa043500.64760700
76Influenza A_Homo sapiens_hsa051640.64027689
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.62328663
78Butanoate metabolism_Homo sapiens_hsa006500.62078119
79Colorectal cancer_Homo sapiens_hsa052100.61802706
80Vitamin B6 metabolism_Homo sapiens_hsa007500.60260329
81Ovarian steroidogenesis_Homo sapiens_hsa049130.59753334
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56390864
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56134188
84Metabolic pathways_Homo sapiens_hsa011000.56040947
85T cell receptor signaling pathway_Homo sapiens_hsa046600.49721871
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49234867
87Chronic myeloid leukemia_Homo sapiens_hsa052200.48751012
88Toxoplasmosis_Homo sapiens_hsa051450.47968581
89B cell receptor signaling pathway_Homo sapiens_hsa046620.47517489
90TNF signaling pathway_Homo sapiens_hsa046680.47491054
91Malaria_Homo sapiens_hsa051440.47062648
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45859918
93Biosynthesis of amino acids_Homo sapiens_hsa012300.45637318
94Asthma_Homo sapiens_hsa053100.44688327
95Glutathione metabolism_Homo sapiens_hsa004800.44551340
96Carbon metabolism_Homo sapiens_hsa012000.43766538
97FoxO signaling pathway_Homo sapiens_hsa040680.42956472
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42342141
99Circadian rhythm_Homo sapiens_hsa047100.42067594
100Autoimmune thyroid disease_Homo sapiens_hsa053200.41240635
101Prostate cancer_Homo sapiens_hsa052150.41140106
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40061262
103Regulation of autophagy_Homo sapiens_hsa041400.39300595
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38919996
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38252402
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38110984
107N-Glycan biosynthesis_Homo sapiens_hsa005100.38080757
108Osteoclast differentiation_Homo sapiens_hsa043800.36743445
109Acute myeloid leukemia_Homo sapiens_hsa052210.34897397
110Cardiac muscle contraction_Homo sapiens_hsa042600.33926914
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33889983
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33766998
113Prolactin signaling pathway_Homo sapiens_hsa049170.33289808
114Pathways in cancer_Homo sapiens_hsa052000.32441135
115Viral myocarditis_Homo sapiens_hsa054160.31418780
116Arachidonic acid metabolism_Homo sapiens_hsa005900.31026818
117Olfactory transduction_Homo sapiens_hsa047400.31017767
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30929844
119Ether lipid metabolism_Homo sapiens_hsa005650.30515847
120Non-small cell lung cancer_Homo sapiens_hsa052230.29332174
121Adherens junction_Homo sapiens_hsa045200.29048413
122Phototransduction_Homo sapiens_hsa047440.28704905
123Type I diabetes mellitus_Homo sapiens_hsa049400.27858019
124Linoleic acid metabolism_Homo sapiens_hsa005910.27674493
125Notch signaling pathway_Homo sapiens_hsa043300.26604495
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26294089
127Peroxisome_Homo sapiens_hsa041460.26244822
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25757120
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25389649
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.24868293
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.24763722
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24417124
133Platelet activation_Homo sapiens_hsa046110.24303269
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23141601
135beta-Alanine metabolism_Homo sapiens_hsa004100.18109987
136Wnt signaling pathway_Homo sapiens_hsa043100.13303053
137Tryptophan metabolism_Homo sapiens_hsa003800.08597292
138Arginine and proline metabolism_Homo sapiens_hsa003300.08514513
139Collecting duct acid secretion_Homo sapiens_hsa049660.08061429
140Nitrogen metabolism_Homo sapiens_hsa009100.07550001
141Caffeine metabolism_Homo sapiens_hsa002320.06204858
142Vitamin digestion and absorption_Homo sapiens_hsa049770.05005565
143Sulfur metabolism_Homo sapiens_hsa009200.04385254
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.03742945
145Fatty acid metabolism_Homo sapiens_hsa012120.03713917
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02466445
147Hippo signaling pathway_Homo sapiens_hsa04390-0.0487576
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0382712
149Taste transduction_Homo sapiens_hsa04742-0.0344516

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