Rank | Gene Set | Z-score |
---|---|---|
1 | proteasome assembly (GO:0043248) | 5.36716252 |
2 | chromatin remodeling at centromere (GO:0031055) | 4.89728438 |
3 | CENP-A containing nucleosome assembly (GO:0034080) | 4.85773804 |
4 | DNA double-strand break processing (GO:0000729) | 4.72708593 |
5 | ribosome assembly (GO:0042255) | 4.35720425 |
6 | mitotic metaphase plate congression (GO:0007080) | 4.07774216 |
7 | histone exchange (GO:0043486) | 4.04449592 |
8 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.91331183 |
9 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.91331183 |
10 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.83274158 |
11 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.80893967 |
12 | DNA replication-independent nucleosome organization (GO:0034724) | 3.80893967 |
13 | DNA replication checkpoint (GO:0000076) | 3.80710606 |
14 | protein localization to kinetochore (GO:0034501) | 3.79024348 |
15 | cullin deneddylation (GO:0010388) | 3.77996603 |
16 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.77861134 |
17 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.67887954 |
18 | replication fork processing (GO:0031297) | 3.67794695 |
19 | metaphase plate congression (GO:0051310) | 3.66443349 |
20 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.64756999 |
21 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.64756999 |
22 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.64654413 |
23 | maturation of 5.8S rRNA (GO:0000460) | 3.62630252 |
24 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.62165470 |
25 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.60738832 |
26 | spindle checkpoint (GO:0031577) | 3.59550207 |
27 | mitotic spindle checkpoint (GO:0071174) | 3.54301500 |
28 | establishment of integrated proviral latency (GO:0075713) | 3.51251510 |
29 | protein deneddylation (GO:0000338) | 3.49739463 |
30 | negative regulation of ligase activity (GO:0051352) | 3.43051320 |
31 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.43051320 |
32 | sister chromatid segregation (GO:0000819) | 3.37381664 |
33 | IMP biosynthetic process (GO:0006188) | 3.36950574 |
34 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.36561284 |
35 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.36561284 |
36 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.36561284 |
37 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.36561284 |
38 | negative regulation of sister chromatid segregation (GO:0033046) | 3.36561284 |
39 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.35305542 |
40 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.33953020 |
41 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.33953020 |
42 | mitochondrial RNA metabolic process (GO:0000959) | 3.31445141 |
43 | negative regulation of chromosome segregation (GO:0051985) | 3.29992775 |
44 | mitotic sister chromatid segregation (GO:0000070) | 3.29679367 |
45 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.26303928 |
46 | DNA ligation (GO:0006266) | 3.25666257 |
47 | protein neddylation (GO:0045116) | 3.23734556 |
48 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.22980042 |
49 | purine nucleobase biosynthetic process (GO:0009113) | 3.21925096 |
50 | histone mRNA metabolic process (GO:0008334) | 3.21879989 |
51 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.21759423 |
52 | kinetochore organization (GO:0051383) | 3.20585437 |
53 | resolution of meiotic recombination intermediates (GO:0000712) | 3.20428802 |
54 | respiratory chain complex IV assembly (GO:0008535) | 3.19938243 |
55 | mitotic spindle assembly checkpoint (GO:0007094) | 3.19934242 |
56 | spindle assembly checkpoint (GO:0071173) | 3.19926408 |
57 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.19773526 |
58 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.19716550 |
59 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.19716550 |
60 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.18874707 |
61 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.18551170 |
62 | postreplication repair (GO:0006301) | 3.13701748 |
63 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.12507072 |
64 | mitotic recombination (GO:0006312) | 3.11128092 |
65 | regulation of sister chromatid segregation (GO:0033045) | 3.10900898 |
66 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.10900898 |
67 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.10900898 |
68 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.07939910 |
69 | termination of RNA polymerase III transcription (GO:0006386) | 3.07939910 |
70 | regulation of centriole replication (GO:0046599) | 3.07919901 |
71 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.07605931 |
72 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.07605931 |
73 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.07605931 |
74 | DNA strand elongation (GO:0022616) | 3.06659704 |
75 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.05844784 |
76 | negative regulation of DNA recombination (GO:0045910) | 3.04742584 |
77 | protein K6-linked ubiquitination (GO:0085020) | 3.03491224 |
78 | kinetochore assembly (GO:0051382) | 3.02074692 |
79 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.01861524 |
80 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.01861524 |
81 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.01533896 |
82 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.01533896 |
83 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.01348598 |
84 | regulation of helicase activity (GO:0051095) | 3.01304602 |
85 | synapsis (GO:0007129) | 3.00989491 |
86 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.00814349 |
87 | establishment of chromosome localization (GO:0051303) | 2.99406524 |
88 | positive regulation of ligase activity (GO:0051351) | 2.98776524 |
89 | nucleobase biosynthetic process (GO:0046112) | 2.97710597 |
90 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.95807819 |
91 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.95807819 |
92 | pseudouridine synthesis (GO:0001522) | 2.95227318 |
93 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.94271325 |
94 | protein localization to chromosome, centromeric region (GO:0071459) | 2.94119427 |
95 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.92984724 |
96 | positive regulation of histone H3-K4 methylation (GO:0051571) | 2.92777384 |
97 | rRNA modification (GO:0000154) | 2.91654006 |
98 | mitotic G2/M transition checkpoint (GO:0044818) | 2.91165853 |
99 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.90679673 |
100 | telomere maintenance via recombination (GO:0000722) | 2.90215098 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.83225823 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.82745614 |
3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.04460342 |
4 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.63864577 |
5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.62282730 |
6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.56457405 |
7 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.97809751 |
8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.84527595 |
9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.72519109 |
10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.66354734 |
11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.64464544 |
12 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.62598543 |
13 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.59411369 |
14 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.56519004 |
15 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.51656347 |
16 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.50607174 |
17 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.46045363 |
18 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.33968184 |
19 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.18178751 |
20 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.15614576 |
21 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.14470742 |
22 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.13838544 |
23 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.11980714 |
24 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.07219487 |
25 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.01035091 |
26 | EWS_26573619_Chip-Seq_HEK293_Human | 1.98112644 |
27 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.94620099 |
28 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.79410625 |
29 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.77842799 |
30 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.76437207 |
31 | FUS_26573619_Chip-Seq_HEK293_Human | 1.76264360 |
32 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.73603775 |
33 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.72583513 |
34 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.72358220 |
35 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.66910839 |
36 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.66238058 |
37 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.65013587 |
38 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.64990645 |
39 | VDR_22108803_ChIP-Seq_LS180_Human | 1.63891700 |
40 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.61773675 |
41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.58704743 |
42 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.57646675 |
43 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.56575266 |
44 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.53362800 |
45 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.52864048 |
46 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.52605092 |
47 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.46647303 |
48 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.42932603 |
49 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.41416712 |
50 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.40692544 |
51 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.40588997 |
52 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.34648454 |
53 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.31767374 |
54 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.31483619 |
55 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.29880643 |
56 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.26518868 |
57 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.25917890 |
58 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.24338742 |
59 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.23479002 |
60 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.22277791 |
61 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.21841442 |
62 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.20956916 |
63 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.20264369 |
64 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.19902077 |
65 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.16759301 |
66 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.13851222 |
67 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.12476982 |
68 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.08833816 |
69 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.08673087 |
70 | * CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.04709131 |
71 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.03585068 |
72 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.02652111 |
73 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.99989008 |
74 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.99817769 |
75 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.99183323 |
76 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.98955956 |
77 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.98231421 |
78 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.98142359 |
79 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.98083917 |
80 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.96973195 |
81 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95999250 |
82 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.92522371 |
83 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.91382775 |
84 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.89933649 |
85 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.89167974 |
86 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.88898031 |
87 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.86791426 |
88 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.86032438 |
89 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.86005335 |
90 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.85397740 |
91 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.85006455 |
92 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.84540584 |
93 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.82967077 |
94 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.80855872 |
95 | * SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.80145665 |
96 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.79677971 |
97 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.79251811 |
98 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.79039361 |
99 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.78975392 |
100 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.78432577 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0010094_abnormal_chromosome_stability | 4.64173387 |
2 | MP0008058_abnormal_DNA_repair | 4.47256951 |
3 | MP0008057_abnormal_DNA_replication | 4.43892096 |
4 | MP0003693_abnormal_embryo_hatching | 3.96143641 |
5 | MP0008877_abnormal_DNA_methylation | 3.68991592 |
6 | MP0004957_abnormal_blastocyst_morpholog | 3.42618313 |
7 | MP0003111_abnormal_nucleus_morphology | 3.14307991 |
8 | MP0003718_maternal_effect | 3.09083480 |
9 | MP0003077_abnormal_cell_cycle | 3.03292466 |
10 | MP0008932_abnormal_embryonic_tissue | 2.45001889 |
11 | MP0000372_irregular_coat_pigmentation | 2.39751419 |
12 | MP0002102_abnormal_ear_morphology | 2.32820669 |
13 | MP0009697_abnormal_copulation | 2.28230501 |
14 | MP0003786_premature_aging | 2.27737363 |
15 | MP0005084_abnormal_gallbladder_morpholo | 2.13511767 |
16 | MP0008007_abnormal_cellular_replicative | 2.13163660 |
17 | MP0006292_abnormal_olfactory_placode | 1.95138751 |
18 | MP0003890_abnormal_embryonic-extraembry | 1.91669113 |
19 | MP0002938_white_spotting | 1.82236692 |
20 | MP0001293_anophthalmia | 1.80359033 |
21 | MP0001529_abnormal_vocalization | 1.79354120 |
22 | MP0006072_abnormal_retinal_apoptosis | 1.76103158 |
23 | MP0003567_abnormal_fetal_cardiomyocyte | 1.70519696 |
24 | MP0003186_abnormal_redox_activity | 1.68971390 |
25 | MP0003941_abnormal_skin_development | 1.65156583 |
26 | MP0008789_abnormal_olfactory_epithelium | 1.58636550 |
27 | MP0008995_early_reproductive_senescence | 1.54107912 |
28 | MP0003806_abnormal_nucleotide_metabolis | 1.50491446 |
29 | MP0006035_abnormal_mitochondrial_morpho | 1.44964641 |
30 | MP0006054_spinal_hemorrhage | 1.44825379 |
31 | MP0003121_genomic_imprinting | 1.43051153 |
32 | MP0006036_abnormal_mitochondrial_physio | 1.38048429 |
33 | MP0005075_abnormal_melanosome_morpholog | 1.36292990 |
34 | MP0001929_abnormal_gametogenesis | 1.32637011 |
35 | MP0002210_abnormal_sex_determination | 1.30688358 |
36 | MP0001764_abnormal_homeostasis | 1.27343721 |
37 | MP0001697_abnormal_embryo_size | 1.25951375 |
38 | MP0003937_abnormal_limbs/digits/tail_de | 1.25546147 |
39 | MP0005253_abnormal_eye_physiology | 1.24933104 |
40 | MP0001672_abnormal_embryogenesis/_devel | 1.24209117 |
41 | MP0005380_embryogenesis_phenotype | 1.24209117 |
42 | MP0001730_embryonic_growth_arrest | 1.21923400 |
43 | MP0000350_abnormal_cell_proliferation | 1.20338287 |
44 | MP0003011_delayed_dark_adaptation | 1.19516279 |
45 | MP0004133_heterotaxia | 1.14956417 |
46 | MP0004147_increased_porphyrin_level | 1.13897491 |
47 | MP0000653_abnormal_sex_gland | 1.12206996 |
48 | MP0001145_abnormal_male_reproductive | 1.11116179 |
49 | MP0002160_abnormal_reproductive_system | 1.07381524 |
50 | MP0004215_abnormal_myocardial_fiber | 1.06122871 |
51 | MP0005395_other_phenotype | 1.05913477 |
52 | MP0002084_abnormal_developmental_patter | 1.05753580 |
53 | MP0010307_abnormal_tumor_latency | 1.03944062 |
54 | MP0002088_abnormal_embryonic_growth/wei | 1.00483850 |
55 | MP0003984_embryonic_growth_retardation | 0.98893311 |
56 | MP0001286_abnormal_eye_development | 0.98686361 |
57 | MP0003136_yellow_coat_color | 0.98671538 |
58 | MP0005645_abnormal_hypothalamus_physiol | 0.97607709 |
59 | MP0002751_abnormal_autonomic_nervous | 0.97542275 |
60 | MP0005367_renal/urinary_system_phenotyp | 0.94451973 |
61 | MP0000516_abnormal_urinary_system | 0.94451973 |
62 | MP0000358_abnormal_cell_content/ | 0.93866951 |
63 | MP0001119_abnormal_female_reproductive | 0.92039200 |
64 | MP0001188_hyperpigmentation | 0.90778419 |
65 | MP0002085_abnormal_embryonic_tissue | 0.90707237 |
66 | MP0002234_abnormal_pharynx_morphology | 0.90687614 |
67 | MP0002233_abnormal_nose_morphology | 0.90437496 |
68 | MP0005551_abnormal_eye_electrophysiolog | 0.89346847 |
69 | MP0000569_abnormal_digit_pigmentation | 0.88765726 |
70 | MP0003195_calcinosis | 0.87964255 |
71 | MP0005499_abnormal_olfactory_system | 0.87918581 |
72 | MP0005394_taste/olfaction_phenotype | 0.87918581 |
73 | MP0002095_abnormal_skin_pigmentation | 0.87795263 |
74 | MP0002163_abnormal_gland_morphology | 0.86711501 |
75 | MP0002254_reproductive_system_inflammat | 0.86383529 |
76 | MP0003221_abnormal_cardiomyocyte_apopto | 0.86234117 |
77 | MP0002837_dystrophic_cardiac_calcinosis | 0.85878683 |
78 | MP0002080_prenatal_lethality | 0.83951873 |
79 | MP0000313_abnormal_cell_death | 0.83404008 |
80 | MP0003119_abnormal_digestive_system | 0.83130248 |
81 | MP0002736_abnormal_nociception_after | 0.81865952 |
82 | MP0008872_abnormal_physiological_respon | 0.81472654 |
83 | MP0000647_abnormal_sebaceous_gland | 0.80681083 |
84 | MP0000427_abnormal_hair_cycle | 0.80083788 |
85 | MP0001984_abnormal_olfaction | 0.78913425 |
86 | MP0002090_abnormal_vision | 0.78355157 |
87 | MP0000631_abnormal_neuroendocrine_gland | 0.76806795 |
88 | MP0005391_vision/eye_phenotype | 0.75861888 |
89 | MP0010030_abnormal_orbit_morphology | 0.74791236 |
90 | MP0003698_abnormal_male_reproductive | 0.74035975 |
91 | MP0003943_abnormal_hepatobiliary_system | 0.72713423 |
92 | MP0002019_abnormal_tumor_incidence | 0.71620341 |
93 | MP0004197_abnormal_fetal_growth/weight/ | 0.70926280 |
94 | MP0005389_reproductive_system_phenotype | 0.69423722 |
95 | MP0005220_abnormal_exocrine_pancreas | 0.68050043 |
96 | MP0001324_abnormal_eye_pigmentation | 0.68045185 |
97 | MP0003755_abnormal_palate_morphology | 0.64859717 |
98 | MP0005408_hypopigmentation | 0.63201245 |
99 | MP0005266_abnormal_metabolism | 0.61605647 |
100 | MP0001177_atelectasis | 0.60700319 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Colon cancer (HP:0003003) | 3.37969293 |
2 | Abnormality of chromosome stability (HP:0003220) | 3.31142497 |
3 | Abnormality of the labia minora (HP:0012880) | 3.27636357 |
4 | Methylmalonic acidemia (HP:0002912) | 3.23665398 |
5 | Meckel diverticulum (HP:0002245) | 3.20980364 |
6 | Chromsome breakage (HP:0040012) | 3.14819999 |
7 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.11144438 |
8 | Acute necrotizing encephalopathy (HP:0006965) | 3.09314106 |
9 | Abnormality of the ileum (HP:0001549) | 3.06621522 |
10 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.02852043 |
11 | Acute encephalopathy (HP:0006846) | 2.99846120 |
12 | Abnormality of the preputium (HP:0100587) | 2.94083357 |
13 | Increased CSF lactate (HP:0002490) | 2.85748475 |
14 | Progressive macrocephaly (HP:0004481) | 2.79912423 |
15 | Abnormality of B cell number (HP:0010975) | 2.76259364 |
16 | Mitochondrial inheritance (HP:0001427) | 2.71313665 |
17 | Abnormality of methionine metabolism (HP:0010901) | 2.69369643 |
18 | Volvulus (HP:0002580) | 2.68166590 |
19 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.67470549 |
20 | Small intestinal stenosis (HP:0012848) | 2.59958926 |
21 | Duodenal stenosis (HP:0100867) | 2.59958926 |
22 | Hepatocellular necrosis (HP:0001404) | 2.59442970 |
23 | B lymphocytopenia (HP:0010976) | 2.53204250 |
24 | Increased serum lactate (HP:0002151) | 2.53047475 |
25 | Increased serum pyruvate (HP:0003542) | 2.52432346 |
26 | Methylmalonic aciduria (HP:0012120) | 2.52427112 |
27 | Pancreatic cysts (HP:0001737) | 2.50366336 |
28 | Increased hepatocellular lipid droplets (HP:0006565) | 2.49359570 |
29 | Hepatic necrosis (HP:0002605) | 2.47844614 |
30 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.46542576 |
31 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.43782135 |
32 | Abnormality of alanine metabolism (HP:0010916) | 2.43782135 |
33 | Hyperalaninemia (HP:0003348) | 2.43782135 |
34 | Type I transferrin isoform profile (HP:0003642) | 2.38739592 |
35 | Abnormality of serum amino acid levels (HP:0003112) | 2.38253311 |
36 | Abnormality of the duodenum (HP:0002246) | 2.36816411 |
37 | Abnormal lung lobation (HP:0002101) | 2.35232319 |
38 | Birth length less than 3rd percentile (HP:0003561) | 2.34092101 |
39 | Supernumerary spleens (HP:0009799) | 2.33578903 |
40 | Hyperglycinemia (HP:0002154) | 2.32427917 |
41 | Lipid accumulation in hepatocytes (HP:0006561) | 2.29783360 |
42 | Pancreatic fibrosis (HP:0100732) | 2.29562375 |
43 | Cerebral edema (HP:0002181) | 2.27602722 |
44 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.23560564 |
45 | Abnormality of glycolysis (HP:0004366) | 2.21580618 |
46 | Renal cortical cysts (HP:0000803) | 2.21260751 |
47 | Sloping forehead (HP:0000340) | 2.20713278 |
48 | Degeneration of anterior horn cells (HP:0002398) | 2.19586265 |
49 | Abnormality of the anterior horn cell (HP:0006802) | 2.19586265 |
50 | 3-Methylglutaconic aciduria (HP:0003535) | 2.18943986 |
51 | Neoplasm of the adrenal gland (HP:0100631) | 2.18331197 |
52 | Abnormal protein glycosylation (HP:0012346) | 2.16780738 |
53 | Abnormal glycosylation (HP:0012345) | 2.16780738 |
54 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.16780738 |
55 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.16780738 |
56 | Median cleft lip (HP:0000161) | 2.13946998 |
57 | Reduced antithrombin III activity (HP:0001976) | 2.11572755 |
58 | Lactic acidosis (HP:0003128) | 2.08916384 |
59 | Medulloblastoma (HP:0002885) | 2.05934115 |
60 | Microvesicular hepatic steatosis (HP:0001414) | 2.04962523 |
61 | Short tibia (HP:0005736) | 2.04427005 |
62 | Hypoproteinemia (HP:0003075) | 2.04388867 |
63 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.04099969 |
64 | Clubbing of toes (HP:0100760) | 2.02738129 |
65 | True hermaphroditism (HP:0010459) | 2.01912144 |
66 | Abnormality of midbrain morphology (HP:0002418) | 2.01412704 |
67 | Molar tooth sign on MRI (HP:0002419) | 2.01412704 |
68 | Neoplasm of the colon (HP:0100273) | 2.00509921 |
69 | Rhabdomyosarcoma (HP:0002859) | 1.99958431 |
70 | Medial flaring of the eyebrow (HP:0010747) | 1.99918467 |
71 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.98111120 |
72 | Embryonal renal neoplasm (HP:0011794) | 1.97024352 |
73 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.95144440 |
74 | Abnormality of vitamin B metabolism (HP:0004340) | 1.91899434 |
75 | Abnormality of the renal cortex (HP:0011035) | 1.88862546 |
76 | Triphalangeal thumb (HP:0001199) | 1.87343722 |
77 | Sensory axonal neuropathy (HP:0003390) | 1.87061452 |
78 | Hypoglycemic coma (HP:0001325) | 1.86829762 |
79 | Gonadotropin excess (HP:0000837) | 1.86094794 |
80 | Neoplasm of the adrenal cortex (HP:0100641) | 1.86037061 |
81 | Renal Fanconi syndrome (HP:0001994) | 1.85923310 |
82 | Hypoplasia of the pons (HP:0012110) | 1.85680458 |
83 | Septo-optic dysplasia (HP:0100842) | 1.84224266 |
84 | Abnormality of the pons (HP:0007361) | 1.82811826 |
85 | Lethargy (HP:0001254) | 1.82460491 |
86 | Myelodysplasia (HP:0002863) | 1.81984000 |
87 | Stomach cancer (HP:0012126) | 1.81220599 |
88 | Abnormality of glycine metabolism (HP:0010895) | 1.79841081 |
89 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.79841081 |
90 | Progressive inability to walk (HP:0002505) | 1.79698435 |
91 | Intestinal atresia (HP:0011100) | 1.79524432 |
92 | Nephronophthisis (HP:0000090) | 1.79056739 |
93 | Combined immunodeficiency (HP:0005387) | 1.78887134 |
94 | Aplastic anemia (HP:0001915) | 1.77607990 |
95 | Thyroiditis (HP:0100646) | 1.77273754 |
96 | Optic disc pallor (HP:0000543) | 1.75999051 |
97 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.75410070 |
98 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.75410070 |
99 | Stenosis of the external auditory canal (HP:0000402) | 1.72918435 |
100 | Small hand (HP:0200055) | 1.72190389 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TRIM28 | 3.50104605 |
2 | EIF2AK3 | 3.49439800 |
3 | BUB1 | 3.32360963 |
4 | SRPK1 | 3.16737509 |
5 | MST4 | 2.82557389 |
6 | ZAK | 2.79869681 |
7 | TSSK6 | 2.79326421 |
8 | TTK | 2.64806005 |
9 | NEK1 | 2.61335502 |
10 | PLK3 | 2.44069399 |
11 | CDC7 | 2.34927205 |
12 | PBK | 2.31974508 |
13 | MKNK2 | 2.30672903 |
14 | NUAK1 | 2.28263801 |
15 | VRK2 | 2.22698706 |
16 | BMPR1B | 2.18881323 |
17 | PLK4 | 2.13350095 |
18 | MKNK1 | 2.13102480 |
19 | EIF2AK1 | 2.08401288 |
20 | VRK1 | 2.05071845 |
21 | MAP4K2 | 1.95746352 |
22 | WNK3 | 1.86858906 |
23 | BRSK2 | 1.85287483 |
24 | WEE1 | 1.77747220 |
25 | TNIK | 1.72323169 |
26 | ERBB3 | 1.71520626 |
27 | BCR | 1.69177108 |
28 | FRK | 1.62763135 |
29 | PLK1 | 1.44991660 |
30 | PDK2 | 1.41616855 |
31 | ACVR1B | 1.26262868 |
32 | PASK | 1.22095543 |
33 | INSRR | 1.15449622 |
34 | NME1 | 1.15051037 |
35 | TAF1 | 1.13227987 |
36 | STK16 | 1.11611884 |
37 | TGFBR1 | 1.10787631 |
38 | EIF2AK2 | 1.09154752 |
39 | CSNK1G1 | 1.07706912 |
40 | ATR | 1.05510222 |
41 | STK38L | 0.95781631 |
42 | PLK2 | 0.93579046 |
43 | CHEK2 | 0.88058816 |
44 | NLK | 0.87188839 |
45 | MAP3K12 | 0.84833374 |
46 | ADRBK2 | 0.84508578 |
47 | STK3 | 0.82913929 |
48 | GRK1 | 0.82100107 |
49 | AURKB | 0.80583177 |
50 | PNCK | 0.78846627 |
51 | SIK3 | 0.75884417 |
52 | MAP3K4 | 0.74763200 |
53 | ATM | 0.74213309 |
54 | BRD4 | 0.73013989 |
55 | CSNK1G3 | 0.69694802 |
56 | BCKDK | 0.68985918 |
57 | NEK2 | 0.67471460 |
58 | BRSK1 | 0.64757113 |
59 | ERBB4 | 0.64254777 |
60 | CHEK1 | 0.61028120 |
61 | PINK1 | 0.58694177 |
62 | STK4 | 0.58206099 |
63 | CCNB1 | 0.57135517 |
64 | CSNK1G2 | 0.56932751 |
65 | STK39 | 0.56600638 |
66 | CSNK1A1L | 0.53503453 |
67 | TLK1 | 0.52275349 |
68 | OXSR1 | 0.48159428 |
69 | CSNK2A1 | 0.47968608 |
70 | CASK | 0.47064119 |
71 | FGFR1 | 0.44224958 |
72 | RPS6KA4 | 0.44079104 |
73 | CSNK2A2 | 0.43015313 |
74 | LATS1 | 0.39754435 |
75 | DAPK1 | 0.39430382 |
76 | CDK3 | 0.38707347 |
77 | DYRK3 | 0.38680258 |
78 | CLK1 | 0.37757415 |
79 | AURKA | 0.37720723 |
80 | DYRK2 | 0.36637926 |
81 | ALK | 0.36427273 |
82 | FLT3 | 0.35944102 |
83 | CDK7 | 0.35641841 |
84 | PRKCE | 0.35147001 |
85 | TEC | 0.34123528 |
86 | MAP2K7 | 0.33934389 |
87 | CDK8 | 0.32416330 |
88 | CSNK1E | 0.31542471 |
89 | CDK9 | 0.31409602 |
90 | CDK1 | 0.30986116 |
91 | CDK2 | 0.30538216 |
92 | WNK4 | 0.30449448 |
93 | PRKCI | 0.29483465 |
94 | CDK19 | 0.28739746 |
95 | PRKDC | 0.26050191 |
96 | RPS6KA5 | 0.25746700 |
97 | PRKCG | 0.25356011 |
98 | OBSCN | 0.25071378 |
99 | PRKACB | 0.23019812 |
100 | PAK3 | 0.23006943 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.23014736 |
2 | Mismatch repair_Homo sapiens_hsa03430 | 3.37851596 |
3 | Non-homologous end-joining_Homo sapiens_hsa03450 | 3.30837911 |
4 | * Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.30251516 |
5 | DNA replication_Homo sapiens_hsa03030 | 3.05688386 |
6 | Homologous recombination_Homo sapiens_hsa03440 | 3.02308187 |
7 | Protein export_Homo sapiens_hsa03060 | 3.02112090 |
8 | RNA polymerase_Homo sapiens_hsa03020 | 2.85232915 |
9 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.53157536 |
10 | Base excision repair_Homo sapiens_hsa03410 | 2.38192939 |
11 | Basal transcription factors_Homo sapiens_hsa03022 | 2.35733144 |
12 | RNA transport_Homo sapiens_hsa03013 | 2.33057793 |
13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.32898110 |
14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.20471064 |
15 | RNA degradation_Homo sapiens_hsa03018 | 2.16950960 |
16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.13190346 |
17 | Spliceosome_Homo sapiens_hsa03040 | 2.07420860 |
18 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.02480997 |
19 | Cell cycle_Homo sapiens_hsa04110 | 1.93953330 |
20 | Parkinsons disease_Homo sapiens_hsa05012 | 1.92779972 |
21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.84820016 |
22 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.64820201 |
23 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.64102036 |
24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.62808491 |
25 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.57094367 |
26 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.55168216 |
27 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.51562581 |
28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.48898189 |
29 | Huntingtons disease_Homo sapiens_hsa05016 | 1.44032099 |
30 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.43714532 |
31 | Ribosome_Homo sapiens_hsa03010 | 1.41058446 |
32 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.39081425 |
33 | Purine metabolism_Homo sapiens_hsa00230 | 1.35880701 |
34 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.34427510 |
35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.33659366 |
36 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.33652866 |
37 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.30914044 |
38 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.25787963 |
39 | Alzheimers disease_Homo sapiens_hsa05010 | 1.06260995 |
40 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.04989491 |
41 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.03501689 |
42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.03248707 |
43 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.02952766 |
44 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.00343451 |
45 | Phototransduction_Homo sapiens_hsa04744 | 0.88608715 |
46 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.86953630 |
47 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.83935412 |
48 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.82229790 |
49 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.81851883 |
50 | Peroxisome_Homo sapiens_hsa04146 | 0.80313986 |
51 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.79125699 |
52 | Carbon metabolism_Homo sapiens_hsa01200 | 0.74711023 |
53 | Metabolic pathways_Homo sapiens_hsa01100 | 0.70124129 |
54 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.66853426 |
55 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.64457983 |
56 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.63171279 |
57 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.59602423 |
58 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.59289268 |
59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.58420357 |
60 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.57873655 |
61 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.49377443 |
62 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.48033084 |
63 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.46580175 |
64 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.46441392 |
65 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.45989208 |
66 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.45325372 |
67 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.43269793 |
68 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.42964398 |
69 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41757266 |
70 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.40263977 |
71 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.39556433 |
72 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.38531942 |
73 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.38431095 |
74 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.36926392 |
75 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.35584543 |
76 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.34787763 |
77 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.34528443 |
78 | Retinol metabolism_Homo sapiens_hsa00830 | 0.33278195 |
79 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.31689756 |
80 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.30945132 |
81 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.30335429 |
82 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.30278253 |
83 | Olfactory transduction_Homo sapiens_hsa04740 | 0.28158252 |
84 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.27464850 |
85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.24950105 |
86 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.24873776 |
87 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.23994355 |
88 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.23426682 |
89 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.22212479 |
90 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.21953044 |
91 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.21605345 |
92 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.21405443 |
93 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.20948416 |
94 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.20790132 |
95 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.19026956 |
96 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.18048958 |
97 | Legionellosis_Homo sapiens_hsa05134 | 0.17817775 |
98 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.15844509 |
99 | Circadian rhythm_Homo sapiens_hsa04710 | 0.15637526 |
100 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.14113687 |