RIOK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)4.47735387
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.44415866
3negative regulation of cell killing (GO:0031342)4.44415866
4low-density lipoprotein particle clearance (GO:0034383)4.41600260
5hepatocyte apoptotic process (GO:0097284)4.33788983
6regulation of B cell receptor signaling pathway (GO:0050855)4.27209209
7regulation of cholesterol storage (GO:0010885)3.79987707
8neutrophil activation involved in immune response (GO:0002283)3.64735221
9positive regulation of receptor recycling (GO:0001921)3.59052782
10production of molecular mediator involved in inflammatory response (GO:0002532)3.58956375
11regulation of gamma-delta T cell activation (GO:0046643)3.58180961
12positive regulation of granulocyte differentiation (GO:0030854)3.48855431
13regulation of platelet aggregation (GO:0090330)3.47271062
14positive regulation of interferon-alpha production (GO:0032727)3.43874149
15negative regulation of lipid storage (GO:0010888)3.41287563
16regulation of gamma-delta T cell differentiation (GO:0045586)3.40421848
17antigen processing and presentation of endogenous antigen (GO:0019883)3.40315683
18macrophage activation (GO:0042116)3.35503394
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31408728
20phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.29740446
21modulation by symbiont of host defense response (GO:0052031)3.29196259
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29196259
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29196259
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.29196259
25modulation by symbiont of host immune response (GO:0052553)3.29196259
26positive regulation by symbiont of host defense response (GO:0052509)3.29196259
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28630102
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28630102
29regulation of interferon-alpha production (GO:0032647)3.27247379
30negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.25378624
31plasma lipoprotein particle clearance (GO:0034381)3.17283531
32regulation of dendritic cell antigen processing and presentation (GO:0002604)3.16013421
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13457877
34detection of external biotic stimulus (GO:0098581)3.12531815
35protoporphyrinogen IX metabolic process (GO:0046501)3.11140761
36response to peptidoglycan (GO:0032494)3.08092032
37negative regulation of T cell mediated immunity (GO:0002710)3.07043912
38regulation of necroptotic process (GO:0060544)3.06828075
39histone H3-K36 demethylation (GO:0070544)3.06081694
40negative T cell selection (GO:0043383)3.05054272
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04099211
42regulation of interferon-beta biosynthetic process (GO:0045357)3.03753984
43positive regulation of p38MAPK cascade (GO:1900745)3.03603047
44detection of bacterium (GO:0016045)3.02663071
45growth hormone receptor signaling pathway (GO:0060396)3.00857154
46B cell receptor signaling pathway (GO:0050853)3.00183037
47valine metabolic process (GO:0006573)2.99519996
48negative regulation of lymphocyte mediated immunity (GO:0002707)2.97484621
49hydrogen peroxide biosynthetic process (GO:0050665)2.96185794
50myeloid cell development (GO:0061515)2.94840853
51thrombin receptor signaling pathway (GO:0070493)2.94056850
52respiratory burst (GO:0045730)2.93757281
53myeloid leukocyte mediated immunity (GO:0002444)2.93267003
54protein K11-linked deubiquitination (GO:0035871)2.93183310
55positive regulation of gamma-delta T cell activation (GO:0046645)2.92062812
56positive T cell selection (GO:0043368)2.91987286
57negative thymic T cell selection (GO:0045060)2.91728202
58negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.90220684
59positive regulation of interferon-beta production (GO:0032728)2.87899841
60positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.87480995
61myeloid cell activation involved in immune response (GO:0002275)2.86681175
62negative regulation of interleukin-12 production (GO:0032695)2.86026698
63erythrocyte development (GO:0048821)2.84227338
64JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83922951
65negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82864575
66negative regulation of T-helper cell differentiation (GO:0045623)2.82864575
67positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.81764379
68positive regulation of antigen processing and presentation (GO:0002579)2.81119471
69mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.80968924
70positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.80968924
71leukocyte aggregation (GO:0070486)2.79930723
72cysteine metabolic process (GO:0006534)2.78454597
73regulation of mast cell degranulation (GO:0043304)2.77299668
74megakaryocyte development (GO:0035855)2.76680571
75regulation of receptor recycling (GO:0001919)2.76463734
76natural killer cell mediated immunity (GO:0002228)2.76311725
77natural killer cell mediated cytotoxicity (GO:0042267)2.76311725
78macroautophagy (GO:0016236)2.76287944
79cellular response to ethanol (GO:0071361)2.74485704
80positive regulation of B cell differentiation (GO:0045579)2.73405862
81granulocyte activation (GO:0036230)2.71615361
82sequestering of metal ion (GO:0051238)2.71394718
83positive regulation of lipid storage (GO:0010884)2.70543379
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.69645284
85regulation of mast cell activation (GO:0033003)2.68777182
86positive thymic T cell selection (GO:0045059)2.68644725
87NIK/NF-kappaB signaling (GO:0038061)2.68255011
88cytokine secretion (GO:0050663)2.67888537
89neutrophil activation (GO:0042119)2.67755862
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66985263
91regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.66382393
92hemoglobin metabolic process (GO:0020027)2.65576645
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65274769
94positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.64888603
95negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.64552666
96regulation of mast cell activation involved in immune response (GO:0033006)2.64518940
97urea metabolic process (GO:0019627)2.64275418
98urea cycle (GO:0000050)2.64275418
99leukocyte migration involved in inflammatory response (GO:0002523)2.64040568
100detection of biotic stimulus (GO:0009595)2.63768882
101killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.63216528
102disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.63216528
103dendritic cell migration (GO:0036336)2.62506744
104regulation of inositol phosphate biosynthetic process (GO:0010919)2.61637989
105regulation of mitochondrial depolarization (GO:0051900)2.60759121
106histone mRNA catabolic process (GO:0071044)2.60364791
107Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60359878
108positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.60335421
109oxygen transport (GO:0015671)2.59659756
110T cell migration (GO:0072678)2.59424114
111regulation of alpha-beta T cell proliferation (GO:0046640)2.57757864
112reactive oxygen species biosynthetic process (GO:1903409)2.57728647
113regulation of regulatory T cell differentiation (GO:0045589)2.56983768
114complement activation, alternative pathway (GO:0006957)2.56980005
115regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.56929025
116cellular extravasation (GO:0045123)2.56879201
117regulation of platelet activation (GO:0010543)2.55860733
118negative regulation of erythrocyte differentiation (GO:0045647)2.54661792
119phospholipid homeostasis (GO:0055091)2.54258319
120peptidyl-glutamic acid carboxylation (GO:0017187)2.54143255
121protein carboxylation (GO:0018214)2.54143255
122macrophage activation involved in immune response (GO:0002281)2.52762837
123neutrophil mediated immunity (GO:0002446)2.50782291
124cellular response to growth hormone stimulus (GO:0071378)2.50293988
125negative regulation of leukocyte mediated immunity (GO:0002704)2.49619432
126regulation of sequestering of triglyceride (GO:0010889)2.49015654
127positive regulation of natural killer cell differentiation (GO:0032825)2.48744200
128positive regulation of insulin receptor signaling pathway (GO:0046628)2.48150957
129positive regulation of cellular response to oxidative stress (GO:1900409)2.46735558
130positive regulation of response to oxidative stress (GO:1902884)2.46735558
131negative regulation of B cell proliferation (GO:0030889)2.46071050
132regulation of B cell differentiation (GO:0045577)2.45299183
133activated T cell proliferation (GO:0050798)2.45220033
134protein targeting to Golgi (GO:0000042)2.44674493
135regulation of lipid storage (GO:0010883)2.44364788
136response to host immune response (GO:0052572)2.44204973
137response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.44204973
138regulation of antigen processing and presentation (GO:0002577)2.44140556
139leukocyte mediated cytotoxicity (GO:0001909)2.43431353
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43082673
141protein-lipid complex assembly (GO:0065005)2.40917327
142plasma lipoprotein particle assembly (GO:0034377)2.40870144
143triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.39081274
144immunoglobulin mediated immune response (GO:0016064)2.36667400
145phospholipid efflux (GO:0033700)2.36190633
146positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.35562530
147positive regulation of mast cell activation (GO:0033005)2.34713582
148nitrogen cycle metabolic process (GO:0071941)2.34243040
149detection of other organism (GO:0098543)2.33905247
150regulation of membrane protein ectodomain proteolysis (GO:0051043)2.33381280
151regulation of RIG-I signaling pathway (GO:0039535)2.32402813
152acute-phase response (GO:0006953)2.32126772
153chronic inflammatory response (GO:0002544)2.31758966
154positive regulation of interleukin-12 production (GO:0032735)2.31600025
155regulation of interleukin-12 biosynthetic process (GO:0045075)2.30786021
156detection of molecule of bacterial origin (GO:0032490)2.29461333
157T-helper 1 type immune response (GO:0042088)2.28551111
158fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.28211396
159regulation of triglyceride catabolic process (GO:0010896)2.27437110
160response to muramyl dipeptide (GO:0032495)2.25363341
161response to host (GO:0075136)2.23882327
162response to host defenses (GO:0052200)2.23882327
163response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.23882327
164positive regulation of cholesterol transport (GO:0032376)2.23807340
165positive regulation of sterol transport (GO:0032373)2.23807340
166positive regulation of leukocyte degranulation (GO:0043302)2.23714479
167regulation of macrophage derived foam cell differentiation (GO:0010743)2.22676757
168regulation of interferon-beta production (GO:0032648)2.22486374
169Golgi transport vesicle coating (GO:0048200)2.22308268
170COPI coating of Golgi vesicle (GO:0048205)2.22308268
171indolalkylamine catabolic process (GO:0046218)2.21528195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.52810447
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.12571295
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.09130641
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.73168422
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.15932293
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.12550647
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.03800421
8* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.96695734
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.96218378
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85454179
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.85130055
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84784090
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.77401895
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.74334792
15GATA1_22025678_ChIP-Seq_K562_Human2.68571649
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64832458
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.63751916
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59097714
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46546695
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44191062
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37561740
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30729923
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.29543546
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14657511
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12208188
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.08441034
27* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06566623
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05937678
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01830981
30CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00457035
31* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.98934971
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.93909418
33GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.86087398
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78654260
35CLOCK_20551151_ChIP-Seq_293T_Human1.76122872
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74424964
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.66207244
38KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.64291306
39* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57086070
40* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56968403
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54588173
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48717377
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47177491
44PU_27001747_Chip-Seq_BMDM_Mouse1.45994380
45SPI1_23547873_ChIP-Seq_NB4_Human1.42180952
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40557469
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38466670
48MYB_26560356_Chip-Seq_TH2_Human1.37991984
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37515628
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37101543
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34967320
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34927635
53* MAF_26560356_Chip-Seq_TH1_Human1.32575149
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29395119
55TP53_16413492_ChIP-PET_HCT116_Human1.27928963
56FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25817963
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.25660053
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25052311
59* MYB_26560356_Chip-Seq_TH1_Human1.24790108
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.21551132
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.19716695
62* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19612437
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18264965
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18014667
65GATA4_25053715_ChIP-Seq_YYC3_Human1.17017278
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15761528
67GATA1_19941827_ChIP-Seq_MEL86_Mouse1.14944624
68GATA1_19941826_ChIP-Seq_K562_Human1.13798322
69GATA3_27048872_Chip-Seq_THYMUS_Human1.13262415
70* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13119041
71* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12635411
72RUNX_20019798_ChIP-Seq_JUKART_Human1.11507699
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11418840
74VDR_24787735_ChIP-Seq_THP-1_Human1.10610174
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08729235
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08460582
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07623805
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07036412
79SMRT_27268052_Chip-Seq_Bcells_Human1.05829199
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05335353
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.05121656
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04968219
83SPI1_23127762_ChIP-Seq_K562_Human1.04729060
84GATA3_26560356_Chip-Seq_TH2_Human1.03947411
85* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02884753
86* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02884753
87SALL4_22934838_ChIP-ChIP_CD34+_Human1.02707592
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01803696
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01728056
90GATA2_19941826_ChIP-Seq_K562_Human1.01722695
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01679653
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01464286
93VDR_24763502_ChIP-Seq_THP-1_Human0.99975358
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99477902
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99013409
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97395710
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97323703
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96238079
99GATA6_25053715_ChIP-Seq_YYC3_Human0.96185467
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96046570
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95649536
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95054558
103* TP63_23658742_ChIP-Seq_EP156T_Human0.93728250
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.92793649
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92484507
106UTX_26944678_Chip-Seq_JUKART_Human0.92214748
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.90795033
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90495295
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.90320580
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90048725
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89689558
112* NCOR1_26117541_ChIP-Seq_K562_Human0.88401727
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87194697
114* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86224199
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85232943
116TCF7_22412390_ChIP-Seq_EML_Mouse0.84653857
117SCL_19346495_ChIP-Seq_HPC-7_Human0.84303197
118SOX2_20726797_ChIP-Seq_SW620_Human0.84276344
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84076872
120TFEB_21752829_ChIP-Seq_HELA_Human0.84045873
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83878234
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.83475702
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83402246
124TCF4_18268006_ChIP-ChIP_LS174T_Human0.83245084
125OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82921337
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82191121
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80873082
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80519722
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79218129
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79218129
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.78586202
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78475139
133CDX2_22108803_ChIP-Seq_LS180_Human0.78356941
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77308703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.86302205
2MP0003436_decreased_susceptibility_to2.84775031
3MP0002138_abnormal_hepatobiliary_system2.68565103
4MP0002139_abnormal_hepatobiliary_system2.67417183
5MP0003303_peritoneal_inflammation2.57149282
6MP0009785_altered_susceptibility_to2.54869425
7MP0009840_abnormal_foam_cell2.53352212
8MP0003191_abnormal_cellular_cholesterol2.22757350
9MP0005058_abnormal_lysosome_morphology2.17291960
10MP0003828_pulmonary_edema2.17252809
11MP0000685_abnormal_immune_system2.15797275
12MP0005365_abnormal_bile_salt2.14636727
13MP0002419_abnormal_innate_immunity2.12791497
14MP0005360_urolithiasis2.08621693
15MP0003724_increased_susceptibility_to1.99563240
16MP0003763_abnormal_thymus_physiology1.94886767
17MP0005000_abnormal_immune_tolerance1.92400756
18MP0000465_gastrointestinal_hemorrhage1.90166620
19MP0005085_abnormal_gallbladder_physiolo1.88231889
20MP0005025_abnormal_response_to1.86585804
21MP0002148_abnormal_hypersensitivity_rea1.86393851
22MP0006082_CNS_inflammation1.84332498
23MP0005387_immune_system_phenotype1.83222816
24MP0001790_abnormal_immune_system1.83222816
25MP0003656_abnormal_erythrocyte_physiolo1.83220466
26MP0003300_gastrointestinal_ulcer1.81132700
27MP0003221_abnormal_cardiomyocyte_apopto1.75494453
28MP0005083_abnormal_biliary_tract1.74898561
29MP0000015_abnormal_ear_pigmentation1.74611809
30MP0003705_abnormal_hypodermis_morpholog1.72575971
31MP0004947_skin_inflammation1.71710602
32MP0004883_abnormal_blood_vessel1.69021475
33MP0003252_abnormal_bile_duct1.65332938
34MP0004484_altered_response_of1.64895353
35MP0001533_abnormal_skeleton_physiology1.62348038
36MP0002452_abnormal_antigen_presenting1.60160993
37MP0002332_abnormal_exercise_endurance1.59237281
38MP0002254_reproductive_system_inflammat1.54806313
39MP0005671_abnormal_response_to1.53163456
40MP0009764_decreased_sensitivity_to1.53002236
41MP0008004_abnormal_stomach_pH1.52005625
42MP0003806_abnormal_nucleotide_metabolis1.51661924
43MP0001845_abnormal_inflammatory_respons1.51114202
44MP0001800_abnormal_humoral_immune1.50647939
45MP0004510_myositis1.50436732
46MP0002723_abnormal_immune_serum1.48676302
47MP0010352_gastrointestinal_tract_polyps1.46781354
48MP0004381_abnormal_hair_follicle1.45031000
49MP0000609_abnormal_liver_physiology1.44877620
50MP0005464_abnormal_platelet_physiology1.42883870
51MP0002877_abnormal_melanocyte_morpholog1.41339933
52MP0001666_abnormal_nutrient_absorption1.41167363
53MP0004147_increased_porphyrin_level1.41104277
54MP0008469_abnormal_protein_level1.40961281
55MP0010329_abnormal_lipoprotein_level1.40379651
56MP0002722_abnormal_immune_system1.38236674
57MP0008057_abnormal_DNA_replication1.37841842
58MP0002405_respiratory_system_inflammati1.36012964
59MP0001819_abnormal_immune_cell1.35972892
60MP0003566_abnormal_cell_adhesion1.35748567
61MP0002166_altered_tumor_susceptibility1.33935770
62MP0002420_abnormal_adaptive_immunity1.33073608
63MP0005076_abnormal_cell_differentiation1.29522905
64MP0005310_abnormal_salivary_gland1.29203349
65MP0005174_abnormal_tail_pigmentation1.28941272
66MP0003866_abnormal_defecation1.28791628
67MP0005164_abnormal_response_to1.27878204
68MP0001851_eye_inflammation1.27265941
69MP0003448_altered_tumor_morphology1.23151969
70MP0003091_abnormal_cell_migration1.21973790
71MP0004808_abnormal_hematopoietic_stem1.21750862
72MP0000343_altered_response_to1.21400513
73MP0001853_heart_inflammation1.19945068
74MP0004130_abnormal_muscle_cell1.18388920
75MP0002006_tumorigenesis1.16299221
76MP0010307_abnormal_tumor_latency1.15888801
77MP0010155_abnormal_intestine_physiology1.15872252
78MP0004185_abnormal_adipocyte_glucose1.15743698
79MP0003186_abnormal_redox_activity1.15576865
80MP0004782_abnormal_surfactant_physiolog1.13754793
81MP0000858_altered_metastatic_potential1.13646272
82MP0009278_abnormal_bone_marrow1.13483080
83MP0005319_abnormal_enzyme/_coenzyme1.13162108
84MP0004019_abnormal_vitamin_homeostasis1.10219135
85MP0008875_abnormal_xenobiotic_pharmacok1.10157515
86MP0003453_abnormal_keratinocyte_physiol1.08626086
87MP0000703_abnormal_thymus_morphology1.07262368
88MP0003195_calcinosis1.07112861
89MP0000569_abnormal_digit_pigmentation1.07032652
90MP0009763_increased_sensitivity_to1.07002790
91MP0009333_abnormal_splenocyte_physiolog1.03147351
92MP0002118_abnormal_lipid_homeostasis1.01013264
93MP0003172_abnormal_lysosome_physiology1.00645102
94MP0001873_stomach_inflammation0.99589789
95MP0009643_abnormal_urine_homeostasis0.97952577
96MP0005332_abnormal_amino_acid0.97917826
97MP0005075_abnormal_melanosome_morpholog0.97594445
98MP0000249_abnormal_blood_vessel0.96674494
99MP0000604_amyloidosis0.96114073
100MP0000716_abnormal_immune_system0.96046263
101MP0005451_abnormal_body_composition0.95203003
102MP0009765_abnormal_xenobiotic_induced0.93812296
103MP0001545_abnormal_hematopoietic_system0.93310304
104MP0005397_hematopoietic_system_phenotyp0.93310304
105MP0001881_abnormal_mammary_gland0.92022921
106MP0005409_darkened_coat_color0.90220660
107MP0003183_abnormal_peptide_metabolism0.89306064
108MP0008260_abnormal_autophagy0.88803331
109MP0001663_abnormal_digestive_system0.87852472
110MP0000598_abnormal_liver_morphology0.87565272
111MP0002398_abnormal_bone_marrow0.87373282
112MP0008438_abnormal_cutaneous_collagen0.87025889
113MP0006054_spinal_hemorrhage0.86042191
114MP0010234_abnormal_vibrissa_follicle0.85895942
115MP0002009_preneoplasia0.85578981
116MP0005166_decreased_susceptibility_to0.84296923
117MP0002998_abnormal_bone_remodeling0.83886254
118MP0003075_altered_response_to0.83690574
119MP0002971_abnormal_brown_adipose0.82945052
120MP0002277_abnormal_respiratory_mucosa0.82306228
121MP0002429_abnormal_blood_cell0.81967643
122MP0002693_abnormal_pancreas_physiology0.80021548
123MP0005666_abnormal_adipose_tissue0.79741976
124MP0001764_abnormal_homeostasis0.79163952
125MP0004084_abnormal_cardiac_muscle0.78645690
126MP0000689_abnormal_spleen_morphology0.77585889
127MP0008874_decreased_physiological_sensi0.77221990
128MP0002933_joint_inflammation0.76965950
129MP0005376_homeostasis/metabolism_phenot0.76405662
130MP0005023_abnormal_wound_healing0.75938793
131MP0005621_abnormal_cell_physiology0.75049545
132MP0003787_abnormal_imprinting0.74440645
133MP0002132_abnormal_respiratory_system0.72816268
134MP0002136_abnormal_kidney_physiology0.71039891
135MP0004264_abnormal_extraembryonic_tissu0.69485714

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.41045773
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.32944732
3Prolonged bleeding time (HP:0003010)5.01282290
4Recurrent gram-negative bacterial infections (HP:0005420)4.90991733
5Recurrent abscess formation (HP:0002722)4.46634015
6Recurrent bacterial skin infections (HP:0005406)4.41570799
7Increased mean platelet volume (HP:0011877)4.07346209
8Abnormal platelet volume (HP:0011876)4.00903950
9Epistaxis (HP:0000421)4.00568063
10T lymphocytopenia (HP:0005403)3.84674940
11Myocardial infarction (HP:0001658)3.72459080
12Abnormality of T cell number (HP:0011839)3.67392057
13Acanthocytosis (HP:0001927)3.64993687
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.56053475
15Menorrhagia (HP:0000132)3.51458194
16Hypochromic microcytic anemia (HP:0004840)3.47227652
17Petechiae (HP:0000967)3.45747227
18Abnormality of macrophages (HP:0004311)3.44324880
19Papillary thyroid carcinoma (HP:0002895)3.18708204
20Microcytic anemia (HP:0001935)3.15151340
21Autoimmune thrombocytopenia (HP:0001973)3.01722001
22Orchitis (HP:0100796)3.01642329
23Tetraparesis (HP:0002273)2.95370917
24Systemic lupus erythematosus (HP:0002725)2.93856115
25Myositis (HP:0100614)2.92632588
26Gingivitis (HP:0000230)2.88756480
27Vacuolated lymphocytes (HP:0001922)2.88733013
28Conjunctival telangiectasia (HP:0000524)2.84280717
29Xanthomatosis (HP:0000991)2.78551778
30Leukocytosis (HP:0001974)2.76380494
31Slow saccadic eye movements (HP:0000514)2.74799070
32Joint hemorrhage (HP:0005261)2.73568933
33Increased cerebral lipofuscin (HP:0011813)2.73269982
34Hydroxyprolinuria (HP:0003080)2.70289768
35Abnormality of proline metabolism (HP:0010907)2.70289768
36Recurrent fungal infections (HP:0002841)2.69838075
37Recurrent skin infections (HP:0001581)2.69510346
38Esophageal varix (HP:0002040)2.69465177
39Intrahepatic cholestasis (HP:0001406)2.69410421
40Hematochezia (HP:0002573)2.67502063
41Retrobulbar optic neuritis (HP:0100654)2.65720650
42Optic neuritis (HP:0100653)2.65720650
43Pustule (HP:0200039)2.63937288
44Deep venous thrombosis (HP:0002625)2.62189841
45Purpura (HP:0000979)2.61437019
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61338347
47Impaired platelet aggregation (HP:0003540)2.59889308
48Abnormal platelet function (HP:0011869)2.59889308
49Complement deficiency (HP:0004431)2.58519421
50Hypoalphalipoproteinemia (HP:0003233)2.57185312
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.52078692
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51546101
53Mediastinal lymphadenopathy (HP:0100721)2.51389718
54Abnormality of the common coagulation pathway (HP:0010990)2.50337211
55Spontaneous hematomas (HP:0007420)2.50326773
56Polycythemia (HP:0001901)2.50071757
57Urticaria (HP:0001025)2.49804996
58Chest pain (HP:0100749)2.47296630
59Gingival bleeding (HP:0000225)2.47265301
60Arterial thrombosis (HP:0004420)2.45744325
61Hypoglycemic coma (HP:0001325)2.44733724
62Autoimmune hemolytic anemia (HP:0001890)2.40436179
63Abnormality of T cells (HP:0002843)2.39104910
64Subacute progressive viral hepatitis (HP:0006572)2.34088698
65Eosinophilia (HP:0001880)2.33542801
66Postural instability (HP:0002172)2.32268630
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.32121053
68Osteolytic defects of the hand bones (HP:0009699)2.31193782
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.31193782
70Abnormality of complement system (HP:0005339)2.30448092
71Chronic diarrhea (HP:0002028)2.29077060
72Encephalitis (HP:0002383)2.26599735
73Hypochromic anemia (HP:0001931)2.25185814
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23160070
75Osteomyelitis (HP:0002754)2.23091775
76Abnormality of the intrinsic pathway (HP:0010989)2.22320422
77Interstitial pulmonary disease (HP:0006530)2.19760812
78Recurrent cutaneous fungal infections (HP:0011370)2.19434957
79Chronic mucocutaneous candidiasis (HP:0002728)2.19434957
80Granulocytopenia (HP:0001913)2.19402621
81Ulnar deviation of the wrist (HP:0003049)2.18751978
82Muscle fiber inclusion bodies (HP:0100299)2.17631381
83Fatigue (HP:0012378)2.17528313
84Periodontitis (HP:0000704)2.16960705
85Glomerulonephritis (HP:0000099)2.15503007
86Obstructive lung disease (HP:0006536)2.15333695
87Chronic obstructive pulmonary disease (HP:0006510)2.15333695
88Cholelithiasis (HP:0001081)2.15175850
89Nausea (HP:0002018)2.14669844
90Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.13288288
91Abnormality of purine metabolism (HP:0004352)2.10233826
92Meningitis (HP:0001287)2.10113398
93Hypolipoproteinemia (HP:0010981)2.09718914
94Gastrointestinal infarctions (HP:0005244)2.09094178
95Hyperglycemia (HP:0003074)2.07851525
96Prostate neoplasm (HP:0100787)2.07527000
97Abnormality of iron homeostasis (HP:0011031)2.06794441
98Vasculitis (HP:0002633)2.06703919
99Thyroid carcinoma (HP:0002890)2.05765838
100Nemaline bodies (HP:0003798)2.05761623
101Urinary glycosaminoglycan excretion (HP:0003541)2.04448021
102Mucopolysacchariduria (HP:0008155)2.04448021
103Recurrent viral infections (HP:0004429)2.03950287
104Myopathic facies (HP:0002058)2.03946424
105Orthostatic hypotension (HP:0001278)2.03638883
106Inflammation of the large intestine (HP:0002037)2.03497182
107Abnormality of transition element cation homeostasis (HP:0011030)2.02636588
108Dysostosis multiplex (HP:0000943)2.01951065
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01144378
110Thrombophlebitis (HP:0004418)2.00912879
111Thick nail (HP:0001805)1.99040541
112Prolonged partial thromboplastin time (HP:0003645)1.98502450
113Axonal loss (HP:0003447)1.97400143
114Abnormality of the fingertips (HP:0001211)1.97253889
115Paralysis (HP:0003470)1.96641320
116Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96321362
117Hyperlipoproteinemia (HP:0010980)1.95678182
118Fat malabsorption (HP:0002630)1.93964305
119Abnormality of eosinophils (HP:0001879)1.93721889
120Abnormal gallbladder morphology (HP:0012437)1.93183206
121Epidermoid cyst (HP:0200040)1.92531207
122Neoplasm of the tracheobronchial system (HP:0100552)1.92068423
123Abnormality of nucleobase metabolism (HP:0010932)1.91227840
124Visual hallucinations (HP:0002367)1.90977649
125Anorexia (HP:0002039)1.90946097
126Viral hepatitis (HP:0006562)1.90079773
127Acute hepatic failure (HP:0006554)1.89157748
128Progressive visual loss (HP:0000529)1.88960270
129Bruising susceptibility (HP:0000978)1.88565059
130Hemoptysis (HP:0002105)1.88244080
131Hemorrhage of the eye (HP:0011885)1.87865685
132Stomatitis (HP:0010280)1.87581508
133Increased serum ferritin (HP:0003281)1.87094031
134Pulmonary embolism (HP:0002204)1.86871566
135Poikilocytosis (HP:0004447)1.86569728
136Recurrent bronchitis (HP:0002837)1.86047688
137Abnormality of polysaccharide metabolism (HP:0011012)1.85382114
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85382114
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85382114
140Keratoconjunctivitis sicca (HP:0001097)1.85258611
141Cellulitis (HP:0100658)1.84594491
142Episodic fever (HP:0001954)1.84129704
143Insulin-resistant diabetes mellitus (HP:0000831)1.83938881
144Joint swelling (HP:0001386)1.83202442
145Abnormality of fatty-acid metabolism (HP:0004359)1.83025837
146Pulmonary infiltrates (HP:0002113)1.82808672
147Peritonitis (HP:0002586)1.82660936
148Keratoconjunctivitis (HP:0001096)1.82617737
149Malnutrition (HP:0004395)1.82471254
150Abnormality of sulfur amino acid metabolism (HP:0004339)1.81631384
151Nephritis (HP:0000123)1.81487358
152Upper motor neuron abnormality (HP:0002127)1.80000928
153Global brain atrophy (HP:0002283)1.79602093
154Elevated erythrocyte sedimentation rate (HP:0003565)1.78935643
155Cerebral inclusion bodies (HP:0100314)1.77609847
156Hyperkalemia (HP:0002153)1.77498947
157Gastrointestinal inflammation (HP:0004386)1.76899547
158Verrucae (HP:0200043)1.74646158
159Papilloma (HP:0012740)1.74646158
160Increased IgM level (HP:0003496)1.72186318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.37113143
2ERN13.00420178
3GRK62.77243200
4TYK22.73759340
5TBK12.69880075
6TAOK32.59533750
7IRAK42.39128257
8BMPR22.34794626
9FGFR42.29879659
10JAK32.22852998
11NEK92.21327115
12TRIB32.09319483
13BLK2.08600325
14IRAK32.03907085
15MST1R2.01075921
16PTK2B1.99732710
17JAK11.94814317
18EPHB11.88694621
19EPHA31.83323064
20CSK1.82645420
21PRPF4B1.75929171
22TTN1.73976977
23IKBKE1.73794193
24SGK21.73771686
25MAP3K21.64781315
26IKBKB1.63037019
27BCKDK1.57172534
28MAP3K31.55701446
29TAOK11.54315623
30PIK3CG1.47590804
31SGK31.46905798
32MAP2K31.45466417
33STK31.42514234
34GRK51.42214745
35PLK21.41670586
36MAP4K11.41340317
37ZAP701.41223415
38WNK11.41209935
39JAK21.40282589
40LATS11.38053657
41FRK1.36031660
42PKN21.35145972
43PTK61.34095924
44PIM11.31758732
45STK101.31547461
46RIPK41.31307146
47CHUK1.29711096
48FES1.25647071
49MAP3K11.25219717
50FGFR31.25089610
51RIPK11.20305573
52MST41.18526009
53PIM21.18180409
54PBK1.14042812
55KSR11.13535635
56EPHA21.13050442
57YES11.12866133
58ERBB21.10484200
59TAOK21.10423660
60MAP3K131.08099466
61IRAK21.06982343
62INSRR1.05537012
63ITK1.01134307
64SIK31.00980423
65SGK4941.00043545
66SGK2231.00043545
67MATK0.99858510
68MARK30.98695167
69FLT30.96420691
70TGFBR20.93336782
71BTK0.93257426
72CDK60.92253234
73HCK0.92252307
74RPS6KA40.89659783
75CAMKK20.88235379
76MAP3K60.87614167
77KSR20.87105610
78TXK0.86738889
79TEC0.85391898
80MAP3K110.85156317
81MAP3K50.84815864
82PDK20.81729977
83NME20.80936928
84DYRK1B0.80923204
85MARK20.79591020
86TRPM70.77836056
87PIK3CA0.76851591
88TESK10.75953617
89STK40.75355721
90ERBB40.73987250
91PDK40.73314655
92PDK30.73314655
93SIK10.73294888
94KIT0.73293076
95ABL20.73131217
96DYRK1A0.72470131
97MET0.71967697
98CAMK1D0.71102744
99MAPK110.68647055
100ACVR1B0.67416926
101OBSCN0.67401947
102FGR0.66666338
103IRAK10.64842646
104CSF1R0.64152097
105EIF2AK10.64049290
106NUAK10.63633461
107MAP3K80.63588751
108ZAK0.63139978
109CDK90.61186294
110DYRK30.61176222
111SYK0.59359131
112EGFR0.58866161
113LCK0.56999170
114NEK20.56487393
115PTK20.55505322
116ABL10.55500180
117AKT30.54626497
118RET0.53468118
119LRRK20.53353361
120LYN0.49782552
121BMX0.48489157
122SGK10.48127745
123STK240.47211394
124PDPK10.46999694
125HIPK20.45084206
126MAP2K60.44546215
127PDK10.44529190
128CDK120.44116762
129PRKAA20.43891642
130KDR0.43636781
131STK380.43167294
132MAP2K20.43035435
133NLK0.42457041
134RAF10.42029098
135PDGFRB0.41854663
136PRKAA10.41753611
137ERBB30.41001713
138MAP3K70.39561821
139MAPK120.38576991
140PRKCQ0.34471487

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.98618634
2Leishmaniasis_Homo sapiens_hsa051402.28141673
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24304302
4Platelet activation_Homo sapiens_hsa046112.00499043
5Complement and coagulation cascades_Homo sapiens_hsa046101.96731840
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.90315437
7Legionellosis_Homo sapiens_hsa051341.89521487
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.77506471
9Non-small cell lung cancer_Homo sapiens_hsa052231.76348558
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71728536
11T cell receptor signaling pathway_Homo sapiens_hsa046601.67777379
12Osteoclast differentiation_Homo sapiens_hsa043801.61492770
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60294807
14Caffeine metabolism_Homo sapiens_hsa002321.59251545
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57376582
16Lysosome_Homo sapiens_hsa041421.56349413
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55581662
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51317399
19Graft-versus-host disease_Homo sapiens_hsa053321.50039437
20Arginine biosynthesis_Homo sapiens_hsa002201.43821669
21Malaria_Homo sapiens_hsa051441.42483690
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39943065
23Measles_Homo sapiens_hsa051621.39418121
24Selenocompound metabolism_Homo sapiens_hsa004501.36081756
25Toxoplasmosis_Homo sapiens_hsa051451.33971569
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32983474
27Fatty acid degradation_Homo sapiens_hsa000711.32783396
28Tuberculosis_Homo sapiens_hsa051521.31843420
29PPAR signaling pathway_Homo sapiens_hsa033201.31603427
30Tryptophan metabolism_Homo sapiens_hsa003801.31020570
31Allograft rejection_Homo sapiens_hsa053301.29497169
32TNF signaling pathway_Homo sapiens_hsa046681.28925290
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28856024
34Influenza A_Homo sapiens_hsa051641.25584389
35Renal cell carcinoma_Homo sapiens_hsa052111.25480948
36Pertussis_Homo sapiens_hsa051331.23874961
37Dorso-ventral axis formation_Homo sapiens_hsa043201.23127399
38Nitrogen metabolism_Homo sapiens_hsa009101.22977809
39Fat digestion and absorption_Homo sapiens_hsa049751.20181854
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.18994114
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.16499456
42Apoptosis_Homo sapiens_hsa042101.15851107
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12674830
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12141739
45Antigen processing and presentation_Homo sapiens_hsa046121.09102754
46Vitamin B6 metabolism_Homo sapiens_hsa007501.08895342
47Pentose phosphate pathway_Homo sapiens_hsa000301.08472720
48Endometrial cancer_Homo sapiens_hsa052131.08314697
49ABC transporters_Homo sapiens_hsa020101.07259464
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07071533
51Insulin resistance_Homo sapiens_hsa049311.06789886
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06621082
53Folate biosynthesis_Homo sapiens_hsa007901.05991498
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.05776321
55Inositol phosphate metabolism_Homo sapiens_hsa005621.03735661
56Starch and sucrose metabolism_Homo sapiens_hsa005001.02979690
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02619581
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.01373884
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00972250
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00562591
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.98319703
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.95700820
63Herpes simplex infection_Homo sapiens_hsa051680.94189645
64Other glycan degradation_Homo sapiens_hsa005110.94082354
65Primary immunodeficiency_Homo sapiens_hsa053400.93841140
66Histidine metabolism_Homo sapiens_hsa003400.92348382
67Viral myocarditis_Homo sapiens_hsa054160.92000392
68Phagosome_Homo sapiens_hsa041450.91455738
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89619205
70Hepatitis C_Homo sapiens_hsa051600.88877707
71VEGF signaling pathway_Homo sapiens_hsa043700.87825591
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87127713
73HIF-1 signaling pathway_Homo sapiens_hsa040660.86903405
74Asthma_Homo sapiens_hsa053100.83417603
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83338137
76Renin-angiotensin system_Homo sapiens_hsa046140.82600535
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.81500403
78mTOR signaling pathway_Homo sapiens_hsa041500.81378636
79B cell receptor signaling pathway_Homo sapiens_hsa046620.81284751
80Hematopoietic cell lineage_Homo sapiens_hsa046400.80893920
81Rheumatoid arthritis_Homo sapiens_hsa053230.79377766
82Peroxisome_Homo sapiens_hsa041460.78842957
83beta-Alanine metabolism_Homo sapiens_hsa004100.78822305
84Vitamin digestion and absorption_Homo sapiens_hsa049770.78074820
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77288190
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76998029
87Glycerolipid metabolism_Homo sapiens_hsa005610.76170167
88Choline metabolism in cancer_Homo sapiens_hsa052310.74052486
89Shigellosis_Homo sapiens_hsa051310.73089379
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.73022202
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71404061
92Salmonella infection_Homo sapiens_hsa051320.71234755
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69896612
94Hepatitis B_Homo sapiens_hsa051610.69363739
95Chemokine signaling pathway_Homo sapiens_hsa040620.68371613
96Prostate cancer_Homo sapiens_hsa052150.67830644
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67618345
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67514631
99Viral carcinogenesis_Homo sapiens_hsa052030.67227380
100Fatty acid metabolism_Homo sapiens_hsa012120.66598406
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66536030
102Type I diabetes mellitus_Homo sapiens_hsa049400.66465608
103Retinol metabolism_Homo sapiens_hsa008300.66368906
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65782338
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65204774
106Chronic myeloid leukemia_Homo sapiens_hsa052200.65130631
107African trypanosomiasis_Homo sapiens_hsa051430.65040295
108Phenylalanine metabolism_Homo sapiens_hsa003600.64496415
109Sulfur metabolism_Homo sapiens_hsa009200.64041029
110Amoebiasis_Homo sapiens_hsa051460.63631049
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.63280163
112Endocytosis_Homo sapiens_hsa041440.62361145
113ErbB signaling pathway_Homo sapiens_hsa040120.61227731
114Glioma_Homo sapiens_hsa052140.60777203
115Prolactin signaling pathway_Homo sapiens_hsa049170.59297944
116GnRH signaling pathway_Homo sapiens_hsa049120.58559111
117Autoimmune thyroid disease_Homo sapiens_hsa053200.58546272
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58494536
119Regulation of autophagy_Homo sapiens_hsa041400.56971687
120Type II diabetes mellitus_Homo sapiens_hsa049300.56306201
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.56004537
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55976944
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.55462415
124Circadian rhythm_Homo sapiens_hsa047100.55093840
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55009350
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55000099
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54882147
128Acute myeloid leukemia_Homo sapiens_hsa052210.54543040
129Pancreatic cancer_Homo sapiens_hsa052120.54080592
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53933891
131Thyroid cancer_Homo sapiens_hsa052160.53346954
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52659870
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51915557
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51287196
135Chemical carcinogenesis_Homo sapiens_hsa052040.50423290
136Fructose and mannose metabolism_Homo sapiens_hsa000510.50081931
137Small cell lung cancer_Homo sapiens_hsa052220.49708793
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49536078
139Galactose metabolism_Homo sapiens_hsa000520.48654833
140p53 signaling pathway_Homo sapiens_hsa041150.47925386
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47884401
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47184353
143FoxO signaling pathway_Homo sapiens_hsa040680.46869218
144Propanoate metabolism_Homo sapiens_hsa006400.46153178

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