RIPK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.64097347
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.64097347
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52044615
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.27777002
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.27777002
6modulation by symbiont of host immune response (GO:0052553)4.27777002
7positive regulation by symbiont of host defense response (GO:0052509)4.27777002
8modulation by symbiont of host defense response (GO:0052031)4.27777002
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.27777002
10antigen processing and presentation of endogenous antigen (GO:0019883)4.27450250
11positive regulation of gamma-delta T cell activation (GO:0046645)3.95515818
12negative regulation of cell killing (GO:0031342)3.77040727
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.77040727
14regulation of interferon-beta biosynthetic process (GO:0045357)3.57539906
15positive regulation of interferon-alpha production (GO:0032727)3.52366038
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.42873058
17neutrophil activation involved in immune response (GO:0002283)3.39419967
18regulation of interferon-alpha production (GO:0032647)3.34843072
19immunoglobulin mediated immune response (GO:0016064)3.34275109
20regulation of vitamin D biosynthetic process (GO:0060556)3.27820055
21detection of other organism (GO:0098543)3.24824271
22macrophage activation involved in immune response (GO:0002281)3.19927514
23germinal center formation (GO:0002467)3.16626174
24regulation of T-helper 1 cell differentiation (GO:0045625)3.15281390
25regulation of gamma-delta T cell differentiation (GO:0045586)3.12222507
26negative regulation of erythrocyte differentiation (GO:0045647)3.05248070
27regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02051077
28regulation of gamma-delta T cell activation (GO:0046643)3.00903786
29detection of bacterium (GO:0016045)3.00712268
30regulation of B cell receptor signaling pathway (GO:0050855)2.95629966
31JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94327642
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94213356
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92808383
34negative regulation of cytokine production involved in immune response (GO:0002719)2.92676698
35positive regulation of type 2 immune response (GO:0002830)2.87822639
36regulation of vitamin metabolic process (GO:0030656)2.87037889
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85697618
38negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.85360497
39regulation of type 2 immune response (GO:0002828)2.85211256
40positive regulation of natural killer cell differentiation (GO:0032825)2.84050415
41positive regulation of B cell differentiation (GO:0045579)2.84048885
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.81804222
43response to host immune response (GO:0052572)2.81804222
44regulation of T-helper 2 cell differentiation (GO:0045628)2.81390210
45regulation of T cell tolerance induction (GO:0002664)2.79050467
46response to type I interferon (GO:0034340)2.78446275
47regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77899916
48positive regulation of interferon-beta production (GO:0032728)2.75909926
49negative regulation of lipid storage (GO:0010888)2.73990548
50regulation of chemokine biosynthetic process (GO:0045073)2.73544462
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71492043
52response to host (GO:0075136)2.71492043
53response to host defenses (GO:0052200)2.71492043
54leukocyte aggregation (GO:0070486)2.70914699
55cellular response to type I interferon (GO:0071357)2.70123669
56type I interferon signaling pathway (GO:0060337)2.70123669
57Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69982833
58regulation of cholesterol storage (GO:0010885)2.67943181
59cellular extravasation (GO:0045123)2.67638749
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66590626
61detection of molecule of bacterial origin (GO:0032490)2.65573767
62B cell mediated immunity (GO:0019724)2.64200951
63response to peptidoglycan (GO:0032494)2.64176215
64negative regulation of type 2 immune response (GO:0002829)2.63386784
65positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.62202736
66regulation of cytokine secretion involved in immune response (GO:0002739)2.60860800
67response to muramyl dipeptide (GO:0032495)2.60858905
68detection of biotic stimulus (GO:0009595)2.60212247
69respiratory burst (GO:0045730)2.59241717
70regulation of podosome assembly (GO:0071801)2.57896070
71NIK/NF-kappaB signaling (GO:0038061)2.57247831
72regulation of membrane protein ectodomain proteolysis (GO:0051043)2.56882559
73regulation of tolerance induction (GO:0002643)2.56764809
74apoptotic cell clearance (GO:0043277)2.56629137
75negative regulation of T cell mediated immunity (GO:0002710)2.56077086
76neutrophil activation (GO:0042119)2.55397011
77pinocytosis (GO:0006907)2.53652561
78regulation of RIG-I signaling pathway (GO:0039535)2.53632766
79positive thymic T cell selection (GO:0045059)2.53180481
80low-density lipoprotein particle clearance (GO:0034383)2.51794230
81interferon-gamma-mediated signaling pathway (GO:0060333)2.51453437
82regulation of antigen processing and presentation (GO:0002577)2.51354505
83protein localization to endosome (GO:0036010)2.51116589
84regulation of B cell differentiation (GO:0045577)2.50781959
85granulocyte activation (GO:0036230)2.48900268
86positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.48457983
87regulation of response to interferon-gamma (GO:0060330)2.48089329
88positive regulation of Cdc42 GTPase activity (GO:0043089)2.47387476
89myeloid dendritic cell activation (GO:0001773)2.46969687
90hepatocyte apoptotic process (GO:0097284)2.43833470
91antigen processing and presentation via MHC class Ib (GO:0002475)2.43717181
92lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43060966
93myeloid dendritic cell differentiation (GO:0043011)2.42589222
94regulation of chronic inflammatory response (GO:0002676)2.41594666
95response to interferon-alpha (GO:0035455)2.40730321
96negative regulation of viral genome replication (GO:0045071)2.39901886
97negative regulation of phagocytosis (GO:0050765)2.38962171
98dendritic cell chemotaxis (GO:0002407)2.38095867
99myeloid cell activation involved in immune response (GO:0002275)2.37544495
100negative regulation of nitric oxide biosynthetic process (GO:0045019)2.37290432
101growth hormone receptor signaling pathway (GO:0060396)2.37235975
102leukocyte cell-cell adhesion (GO:0007159)2.37203116
103defense response to protozoan (GO:0042832)2.37164630
104cellular response to virus (GO:0098586)2.36326609
105negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.36133244
106positive regulation of chemokine biosynthetic process (GO:0045080)2.35756537
107cellular response to interferon-alpha (GO:0035457)2.35448416
108production of molecular mediator involved in inflammatory response (GO:0002532)2.35423291
109response to protozoan (GO:0001562)2.35312508
110regulation of leukocyte degranulation (GO:0043300)2.35241324
111cellular response to interferon-gamma (GO:0071346)2.35177746
112positive regulation of tolerance induction (GO:0002645)2.34513211
113negative regulation of lymphocyte mediated immunity (GO:0002707)2.34192647
114regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.34000935
115protein carboxylation (GO:0018214)2.33953532
116peptidyl-glutamic acid carboxylation (GO:0017187)2.33953532
117natural killer cell mediated immunity (GO:0002228)2.32831433
118natural killer cell mediated cytotoxicity (GO:0042267)2.32831433
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31046612
120regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.29990870
121regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.29773577
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.29459495
123macrophage activation (GO:0042116)2.28090817
124T-helper 1 type immune response (GO:0042088)2.27190811
125regulation of natural killer cell differentiation (GO:0032823)2.26624650
126regulation of interleukin-8 biosynthetic process (GO:0045414)2.26179490
127negative regulation of interleukin-12 production (GO:0032695)2.24992558
128positive regulation of cellular amide metabolic process (GO:0034250)2.22745702
129positive regulation of humoral immune response (GO:0002922)2.21985181
130positive regulation of antigen processing and presentation (GO:0002579)2.21983834
131detection of external biotic stimulus (GO:0098581)2.20199411
132positive regulation of isotype switching (GO:0045830)2.20147641
133T cell migration (GO:0072678)2.20121105
134response to laminar fluid shear stress (GO:0034616)2.20082351
135dendritic cell differentiation (GO:0097028)2.18264290
136positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.17952222
137positive regulation of B cell mediated immunity (GO:0002714)2.17667592
138positive regulation of immunoglobulin mediated immune response (GO:0002891)2.17667592
139positive regulation of cytokine biosynthetic process (GO:0042108)2.17392969
140regulation of interferon-beta production (GO:0032648)2.17281444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.83385399
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85353505
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.66009271
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.57804135
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.51813965
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.40596896
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.18127049
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00551335
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94341285
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92033907
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.82306003
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81172144
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78389066
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78079508
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71231845
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.58130144
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50998792
18E2F7_22180533_ChIP-Seq_HELA_Human2.41098133
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.39520301
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38944108
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30242181
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28893980
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16386412
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.15917314
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.10144212
26* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05365540
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.99997919
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98136281
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95282008
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95133385
31MYB_26560356_Chip-Seq_TH2_Human1.94585859
32SCL_19346495_ChIP-Seq_HPC-7_Human1.92937224
33MAF_26560356_Chip-Seq_TH1_Human1.84755894
34GATA1_22025678_ChIP-Seq_K562_Human1.84708998
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84329637
36* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82942841
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82194325
38MYC_22102868_ChIP-Seq_BL_Human1.80594249
39VDR_21846776_ChIP-Seq_THP-1_Human1.77005333
40MYB_26560356_Chip-Seq_TH1_Human1.76837414
41RUNX_20019798_ChIP-Seq_JUKART_Human1.74328950
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72730620
43SPI1_23547873_ChIP-Seq_NB4_Human1.71791619
44VDR_24763502_ChIP-Seq_THP-1_Human1.69980614
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66599888
46CLOCK_20551151_ChIP-Seq_293T_Human1.66528632
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63038257
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.61709497
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60013269
50* TCF7_22412390_ChIP-Seq_EML_Mouse1.54752742
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.53493663
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53074572
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52796885
54UTX_26944678_Chip-Seq_JUKART_Human1.45967105
55PU_27001747_Chip-Seq_BMDM_Mouse1.44700275
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43926433
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37769757
58SPI1_23127762_ChIP-Seq_K562_Human1.30672095
59LXR_22292898_ChIP-Seq_THP-1_Human1.29510678
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.29338093
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28435125
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28023259
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27621467
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26405796
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26349813
66RACK7_27058665_Chip-Seq_MCF-7_Human1.25638665
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25346726
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.23795796
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.22472153
70GATA3_27048872_Chip-Seq_THYMUS_Human1.21077719
71* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20845751
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20687201
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20208059
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17268534
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14850571
76* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14189937
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13493349
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12530915
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12314601
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12091896
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11450688
82* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11314528
83* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10883190
84VDR_24787735_ChIP-Seq_THP-1_Human1.10537256
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09668106
86* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09115985
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07987921
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.07823608
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05626987
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.05397648
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04888261
92FOXM1_23109430_ChIP-Seq_U2OS_Human1.03965942
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02309201
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01559842
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01559842
96* KDM2B_26808549_Chip-Seq_JURKAT_Human1.00539457
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.00217412
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97970659
99* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97197475
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96939250
101HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96134245
102MAF_26560356_Chip-Seq_TH2_Human0.96026376
103GATA2_19941826_ChIP-Seq_K562_Human0.95535016
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95329076
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95023712
106SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94979743
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94537081
108GATA3_26560356_Chip-Seq_TH2_Human0.93862731
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93809392
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93670921
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93315585
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93184353
113TFEB_21752829_ChIP-Seq_HELA_Human0.92725738
114CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92240763
115* KDM2B_26808549_Chip-Seq_DND41_Human0.91822715
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91441582
117* NCOR1_26117541_ChIP-Seq_K562_Human0.90711689
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90321150
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89113898
120GATA1_19941826_ChIP-Seq_K562_Human0.87736004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.02981618
2MP0003436_decreased_susceptibility_to2.74142540
3MP0003300_gastrointestinal_ulcer2.69619889
4MP0003724_increased_susceptibility_to2.54417387
5MP0003303_peritoneal_inflammation2.35146983
6MP0009785_altered_susceptibility_to2.32859751
7MP0000685_abnormal_immune_system2.26181319
8MP0005451_abnormal_body_composition2.17165182
9MP0002419_abnormal_innate_immunity2.15527068
10MP0001790_abnormal_immune_system2.07810986
11MP0005387_immune_system_phenotype2.07810986
12MP0005000_abnormal_immune_tolerance2.06483234
13MP0002139_abnormal_hepatobiliary_system2.04420809
14MP0005025_abnormal_response_to2.03241331
15MP0001800_abnormal_humoral_immune1.98797351
16MP0005360_urolithiasis1.98512369
17MP0002166_altered_tumor_susceptibility1.96815267
18MP0002452_abnormal_antigen_presenting1.92449454
19MP0002148_abnormal_hypersensitivity_rea1.88334541
20MP0005464_abnormal_platelet_physiology1.87860282
21MP0003705_abnormal_hypodermis_morpholog1.87837477
22MP0002723_abnormal_immune_serum1.81552726
23MP0002006_tumorigenesis1.79635787
24MP0003191_abnormal_cellular_cholesterol1.79631853
25MP0005671_abnormal_response_to1.76474442
26MP0005058_abnormal_lysosome_morphology1.74981901
27MP0004947_skin_inflammation1.71150415
28MP0002420_abnormal_adaptive_immunity1.68686243
29MP0001819_abnormal_immune_cell1.68329366
30MP0002138_abnormal_hepatobiliary_system1.67055557
31MP0006082_CNS_inflammation1.65121083
32MP0008438_abnormal_cutaneous_collagen1.62378785
33MP0010155_abnormal_intestine_physiology1.61952002
34MP0001533_abnormal_skeleton_physiology1.61292318
35MP0009840_abnormal_foam_cell1.60113463
36MP0002405_respiratory_system_inflammati1.57934772
37MP0010352_gastrointestinal_tract_polyps1.57154063
38MP0005365_abnormal_bile_salt1.53491003
39MP0001845_abnormal_inflammatory_respons1.53214958
40MP0001853_heart_inflammation1.50744129
41MP0009278_abnormal_bone_marrow1.49132576
42MP0002396_abnormal_hematopoietic_system1.47472310
43MP0003763_abnormal_thymus_physiology1.45651990
44MP0005397_hematopoietic_system_phenotyp1.45213975
45MP0001545_abnormal_hematopoietic_system1.45213975
46MP0008260_abnormal_autophagy1.41593153
47MP0001873_stomach_inflammation1.40595403
48MP0003566_abnormal_cell_adhesion1.40313111
49MP0008469_abnormal_protein_level1.38154968
50MP0008004_abnormal_stomach_pH1.37676873
51* MP0002398_abnormal_bone_marrow1.37294558
52MP0003252_abnormal_bile_duct1.35975914
53MP0005164_abnormal_response_to1.34152285
54MP0003448_altered_tumor_morphology1.33849954
55* MP0000716_abnormal_immune_system1.33754033
56MP0010307_abnormal_tumor_latency1.32989594
57MP0003828_pulmonary_edema1.31375941
58MP0009764_decreased_sensitivity_to1.31343686
59MP0009333_abnormal_splenocyte_physiolog1.31286205
60MP0005085_abnormal_gallbladder_physiolo1.28563732
61MP0006054_spinal_hemorrhage1.28136623
62MP0000465_gastrointestinal_hemorrhage1.25410409
63* MP0000689_abnormal_spleen_morphology1.24809417
64MP0000858_altered_metastatic_potential1.24565069
65MP0000604_amyloidosis1.24548787
66MP0003656_abnormal_erythrocyte_physiolo1.22977295
67MP0005076_abnormal_cell_differentiation1.22011025
68MP0003172_abnormal_lysosome_physiology1.20253334
69MP0004808_abnormal_hematopoietic_stem1.20076491
70MP0000609_abnormal_liver_physiology1.19272545
71MP0002877_abnormal_melanocyte_morpholog1.19087902
72* MP0002722_abnormal_immune_system1.16971921
73MP0004883_abnormal_blood_vessel1.14809322
74* MP0002429_abnormal_blood_cell1.14569326
75MP0003690_abnormal_glial_cell1.14076313
76MP0005023_abnormal_wound_healing1.11009011
77MP0004510_myositis1.10621167
78MP0000569_abnormal_digit_pigmentation1.10540542
79MP0002332_abnormal_exercise_endurance1.10273300
80MP0002998_abnormal_bone_remodeling1.07417962
81MP0002933_joint_inflammation1.05102719
82MP0010329_abnormal_lipoprotein_level1.03550448
83MP0010234_abnormal_vibrissa_follicle1.02719739
84MP0009763_increased_sensitivity_to1.02285569
85MP0003183_abnormal_peptide_metabolism1.01302183
86MP0003453_abnormal_keratinocyte_physiol0.97750047
87MP0000343_altered_response_to0.97395421
88MP0000490_abnormal_crypts_of0.97183948
89MP0001851_eye_inflammation0.97105096
90MP0003866_abnormal_defecation0.95867868
91MP0005666_abnormal_adipose_tissue0.94846678
92MP0002254_reproductive_system_inflammat0.94340370
93MP0008875_abnormal_xenobiotic_pharmacok0.92868645
94MP0010368_abnormal_lymphatic_system0.92411674
95MP0004185_abnormal_adipocyte_glucose0.92245698
96MP0005310_abnormal_salivary_gland0.92158175
97MP0001542_abnormal_bone_strength0.90782083
98MP0003091_abnormal_cell_migration0.90493596
99MP0000598_abnormal_liver_morphology0.90463381
100MP0005319_abnormal_enzyme/_coenzyme0.86930751
101MP0005165_increased_susceptibility_to0.86481893
102MP0003186_abnormal_redox_activity0.86418063
103MP0005390_skeleton_phenotype0.86109048
104MP0001666_abnormal_nutrient_absorption0.85960158
105MP0001958_emphysema0.85709200
106* MP0000703_abnormal_thymus_morphology0.84140598
107MP0003279_aneurysm0.83172362
108MP0000249_abnormal_blood_vessel0.82933732
109MP0005166_decreased_susceptibility_to0.81827948
110MP0002928_abnormal_bile_duct0.81703907
111MP0009643_abnormal_urine_homeostasis0.81332025
112MP0003075_altered_response_to0.81303448
113MP0002060_abnormal_skin_morphology0.80366624
114MP0005083_abnormal_biliary_tract0.80068601
115MP0002136_abnormal_kidney_physiology0.79359109
116MP0000767_abnormal_smooth_muscle0.78007140
117MP0001663_abnormal_digestive_system0.76092010
118MP0003795_abnormal_bone_structure0.76055670
119MP0003045_fibrosis0.75208204
120MP0001216_abnormal_epidermal_layer0.69808006
121MP0005275_abnormal_skin_tensile0.68589611

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.66587970
2Recurrent abscess formation (HP:0002722)4.18989132
3Recurrent bacterial skin infections (HP:0005406)4.07125598
4Abnormality of liposaccharide metabolism (HP:0010968)4.00283071
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.00283071
6Abnormality of glycolipid metabolism (HP:0010969)4.00283071
7Recurrent gram-negative bacterial infections (HP:0005420)3.99635353
8Myocardial infarction (HP:0001658)3.46760703
9Myositis (HP:0100614)3.41281057
10Elevated erythrocyte sedimentation rate (HP:0003565)3.37653078
11Autoimmune thrombocytopenia (HP:0001973)3.35682459
12Systemic lupus erythematosus (HP:0002725)3.03549545
13Vacuolated lymphocytes (HP:0001922)3.02316018
14Recurrent fungal infections (HP:0002841)3.00534429
15Gingival bleeding (HP:0000225)2.90818259
16Orchitis (HP:0100796)2.89327715
17Abnormality of macrophages (HP:0004311)2.86990429
18Recurrent viral infections (HP:0004429)2.86964219
19Keratoconjunctivitis sicca (HP:0001097)2.85460644
20Spontaneous hematomas (HP:0007420)2.83975842
21Pustule (HP:0200039)2.83496990
22Mediastinal lymphadenopathy (HP:0100721)2.80124578
23Hematochezia (HP:0002573)2.79578327
24Loss of speech (HP:0002371)2.77149233
25Joint hemorrhage (HP:0005261)2.75779782
26Recurrent skin infections (HP:0001581)2.72795289
27Osteolytic defects of the hand bones (HP:0009699)2.70625680
28Osteolytic defects of the phalanges of the hand (HP:0009771)2.70625680
29Periodontitis (HP:0000704)2.68071896
30Gingivitis (HP:0000230)2.65348393
31Arterial thrombosis (HP:0004420)2.63161784
32Thrombocytosis (HP:0001894)2.58148522
33Amyloidosis (HP:0011034)2.57663182
34Deep venous thrombosis (HP:0002625)2.57323441
35Complement deficiency (HP:0004431)2.55724511
36Peritonitis (HP:0002586)2.55040787
37Vasculitis (HP:0002633)2.52574138
38Keratoconjunctivitis (HP:0001096)2.51408034
39Interstitial pulmonary disease (HP:0006530)2.45802846
40Esophageal varix (HP:0002040)2.44412820
41Cellulitis (HP:0100658)2.44144354
42Epistaxis (HP:0000421)2.42189055
43Abnormality of the common coagulation pathway (HP:0010990)2.40378529
44Abnormality of complement system (HP:0005339)2.35262921
45Xanthomatosis (HP:0000991)2.35252379
46Retrobulbar optic neuritis (HP:0100654)2.32667118
47Optic neuritis (HP:0100653)2.32667118
48Gastrointestinal infarctions (HP:0005244)2.28037894
49Inflammation of the large intestine (HP:0002037)2.27167191
50Abnormal platelet volume (HP:0011876)2.25415129
51Vertebral compression fractures (HP:0002953)2.24496926
52Impaired platelet aggregation (HP:0003540)2.22306907
53Abnormal platelet function (HP:0011869)2.22306907
54Glomerulonephritis (HP:0000099)2.22293689
55Increased IgM level (HP:0003496)2.17745209
56Gangrene (HP:0100758)2.17720635
57Increased cerebral lipofuscin (HP:0011813)2.16710810
58Colitis (HP:0002583)2.16119242
59Abnormality of T cell number (HP:0011839)2.15646932
60Dysostosis multiplex (HP:0000943)2.15495662
61Gastrointestinal inflammation (HP:0004386)2.14639300
62Pulmonary infiltrates (HP:0002113)2.14490311
63Stomatitis (HP:0010280)2.13954855
64Mucopolysacchariduria (HP:0008155)2.13712312
65Urinary glycosaminoglycan excretion (HP:0003541)2.13712312
66Chronic otitis media (HP:0000389)2.13475725
67Neurofibrillary tangles (HP:0002185)2.13092031
68Prolonged bleeding time (HP:0003010)2.10828815
69Osteomyelitis (HP:0002754)2.09392128
70Thrombophlebitis (HP:0004418)2.08527440
71Increased mean platelet volume (HP:0011877)2.08308689
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07726313
73Malnutrition (HP:0004395)2.07290316
74T lymphocytopenia (HP:0005403)2.07108715
75Tetraparesis (HP:0002273)2.06150052
76Menorrhagia (HP:0000132)2.04786375
77Abnormality of T cell physiology (HP:0011840)2.03930022
78Abnormality of the nasal mucosa (HP:0000433)2.03573189
79Hypergammaglobulinemia (HP:0010702)2.03389245
80Joint swelling (HP:0001386)2.02602306
81Increased serum ferritin (HP:0003281)2.02159107
82Abnormality of T cells (HP:0002843)2.02107274
83Leukocytosis (HP:0001974)2.01938057
84Abnormality of polysaccharide metabolism (HP:0011012)2.01368812
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01368812
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01368812
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.01180965
88Thin bony cortex (HP:0002753)2.00451215
89Recurrent cutaneous fungal infections (HP:0011370)2.00302239
90Chronic mucocutaneous candidiasis (HP:0002728)2.00302239
91Meningitis (HP:0001287)2.00239477
92Purpura (HP:0000979)1.99584348
93Glomerulopathy (HP:0100820)1.97624639
94Spondylolisthesis (HP:0003302)1.97414521
95Disinhibition (HP:0000734)1.96495115
96Nephritis (HP:0000123)1.96249121
97Pulmonary embolism (HP:0002204)1.96077263
98Axonal loss (HP:0003447)1.95820606
99Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95445453
100Basal ganglia calcification (HP:0002135)1.94678534
101Hemoptysis (HP:0002105)1.94145875
102IgM deficiency (HP:0002850)1.93887701
103Urticaria (HP:0001025)1.93728527
104Cervical subluxation (HP:0003308)1.93399099
105Abnormality of the pericardium (HP:0001697)1.92681181
106Recurrent bronchitis (HP:0002837)1.92088895
107Obstructive lung disease (HP:0006536)1.90158118
108Chronic obstructive pulmonary disease (HP:0006510)1.90158118
109Increased neuronal autofluorescent lipopigment (HP:0002074)1.88715825
110Chronic diarrhea (HP:0002028)1.88412656
111Nasal polyposis (HP:0100582)1.88368692
112Nuclear cataract (HP:0100018)1.88312062
113Protrusio acetabuli (HP:0003179)1.87712071
114Polycythemia (HP:0001901)1.87503242
115Autoimmune hemolytic anemia (HP:0001890)1.86840262
116Hemorrhage of the eye (HP:0011885)1.84378419
117Acne (HP:0001061)1.84377534
118Cerebral inclusion bodies (HP:0100314)1.84298669
119Intrahepatic cholestasis (HP:0001406)1.83961598
120Abnormality of the fingertips (HP:0001211)1.83709775
121Encephalitis (HP:0002383)1.83579810
122Cerebral aneurysm (HP:0004944)1.82665080
123Increased IgE level (HP:0003212)1.82642674
124Aortic aneurysm (HP:0004942)1.82161484
125Chest pain (HP:0100749)1.81759619
126Abnormality of the pleura (HP:0002103)1.80426371
127Segmental peripheral demyelination/remyelination (HP:0003481)1.79505959
128Anorexia (HP:0002039)1.78522967
129Abnormality of the peritoneum (HP:0002585)1.78267524
130Dilatation of the ascending aorta (HP:0005111)1.77968861
131Emphysema (HP:0002097)1.76300140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.11339694
2MAP3K143.04298774
3MAP4K12.85610398
4ERN12.84232355
5TBK12.57787983
6TYK22.54965492
7JAK32.45395187
8FGFR42.16697732
9TRIB32.14798502
10IKBKE2.10496311
11TAOK32.04522857
12STK102.02765286
13KIT2.00962093
14IRAK42.00515191
15FLT31.87203515
16PKN21.85903531
17JAK11.82840071
18TGFBR21.80223164
19ZAP701.78745863
20TAOK21.75209461
21TXK1.73160038
22IKBKB1.65766274
23MAP2K31.65693499
24BMPR21.65596795
25EPHB11.63387558
26GRK71.58682079
27CSK1.57617902
28MAP3K101.45318365
29TEC1.43252268
30BTK1.41500016
31CHUK1.40658287
32PTK61.40273920
33DDR21.39383257
34FGFR31.37229441
35CDC42BPA1.36203118
36MAP3K31.35829238
37CSF1R1.34667207
38EPHA31.32826970
39BLK1.29321680
40TTN1.28507550
41NEK91.27899145
42ITK1.27483645
43PIM21.25208155
44IRAK31.25146482
45FGR1.21481270
46LRRK21.21317767
47EEF2K1.20554043
48MAP3K11.20134169
49PIM11.19936426
50KDR1.18334989
51RPS6KA41.17887508
52SIK11.11817626
53JAK21.11235246
54STK31.09842661
55MATK1.09703742
56CAMK1D1.08835492
57MOS1.07156722
58HCK1.06431983
59RIPK41.04212970
60LCK0.99679292
61NLK0.97653549
62CDK60.97620486
63SIK30.97377684
64MAP3K130.96479381
65CDK120.96158808
66NME20.95942074
67GRK60.94144770
68SYK0.91979379
69PDPK10.89370377
70FRK0.89003757
71SMG10.88509018
72TGFBR10.87698140
73TESK20.87452809
74TRPM70.83743184
75ICK0.81953822
76MARK30.79075615
77KSR20.79064358
78LYN0.76259982
79SCYL20.75632172
80BMX0.74720946
81LATS10.72421282
82IRAK10.72072336
83IRAK20.70924282
84PAK40.70506507
85PIK3CG0.68020975
86PRKD20.67677939
87PDGFRB0.67148674
88MARK20.66686638
89MAP3K20.66480996
90MST1R0.65383372
91CDK40.64680866
92STK40.64649652
93MAPK70.61571270
94BRSK20.61374646
95MAP3K60.60409566
96MAPK110.58826493
97PDK10.56754054
98TAOK10.56724541
99MAP3K110.56169328
100MST40.56137674
101PRKG20.55297912
102ABL10.54888185
103MAP3K80.54461473
104PDGFRA0.53932282
105YES10.53753696
106HIPK20.53708949
107NUAK10.53184418
108STK380.52931433
109EGFR0.50282144
110EPHA20.49811661
111CLK10.47675139
112PTK20.47646238
113PAK20.45312800
114TIE10.44705514
115ABL20.43661693
116RET0.42721769
117SGK30.41313131
118TESK10.41242371
119MAPK150.41070949
120GSK3A0.40421537
121RPS6KL10.40414065
122RPS6KC10.40414065
123MAPKAPK20.40248471
124PRKAA20.39788652
125MELK0.39704213
126MAP3K50.39693471
127CDK90.38844484
128IGF1R0.38636705
129FES0.37985000
130CAMK1G0.37895609
131DYRK1B0.36341388
132MTOR0.34954526
133NEK20.33395684

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.89846923
2Leishmaniasis_Homo sapiens_hsa051402.64122608
3* NF-kappa B signaling pathway_Homo sapiens_hsa040642.16024468
4Osteoclast differentiation_Homo sapiens_hsa043802.02816617
5Malaria_Homo sapiens_hsa051441.90693942
6Measles_Homo sapiens_hsa051621.90068918
7Complement and coagulation cascades_Homo sapiens_hsa046101.89478998
8Caffeine metabolism_Homo sapiens_hsa002321.86771698
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85909650
10* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81831465
11Graft-versus-host disease_Homo sapiens_hsa053321.78266015
12Legionellosis_Homo sapiens_hsa051341.74715578
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73751689
14Antigen processing and presentation_Homo sapiens_hsa046121.73196944
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.64670192
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58667398
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.55108261
18Toxoplasmosis_Homo sapiens_hsa051451.54861099
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51899536
20* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51722185
21Allograft rejection_Homo sapiens_hsa053301.47754182
22Pertussis_Homo sapiens_hsa051331.47476116
23* TNF signaling pathway_Homo sapiens_hsa046681.45785989
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.45412306
25Primary immunodeficiency_Homo sapiens_hsa053401.42122785
26Hematopoietic cell lineage_Homo sapiens_hsa046401.41151216
27B cell receptor signaling pathway_Homo sapiens_hsa046621.35209698
28Herpes simplex infection_Homo sapiens_hsa051681.33917222
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.33902592
30Influenza A_Homo sapiens_hsa051641.32153786
31Tuberculosis_Homo sapiens_hsa051521.31532296
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23530438
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19753024
34Lysosome_Homo sapiens_hsa041421.17712655
35* Apoptosis_Homo sapiens_hsa042101.15255685
36Other glycan degradation_Homo sapiens_hsa005111.14667793
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07620950
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.05233936
39Hepatitis B_Homo sapiens_hsa051611.04866964
40Prion diseases_Homo sapiens_hsa050201.02560017
41Chronic myeloid leukemia_Homo sapiens_hsa052201.01090435
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00330383
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98240269
44* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97296415
45Shigellosis_Homo sapiens_hsa051310.97077223
46Small cell lung cancer_Homo sapiens_hsa052220.94440304
47African trypanosomiasis_Homo sapiens_hsa051430.94102243
48ABC transporters_Homo sapiens_hsa020100.92851014
49VEGF signaling pathway_Homo sapiens_hsa043700.90882866
50T cell receptor signaling pathway_Homo sapiens_hsa046600.90152892
51* Hepatitis C_Homo sapiens_hsa051600.89044755
52Salmonella infection_Homo sapiens_hsa051320.89026977
53Bladder cancer_Homo sapiens_hsa052190.88767625
54Acute myeloid leukemia_Homo sapiens_hsa052210.87766515
55Asthma_Homo sapiens_hsa053100.86603470
56Viral myocarditis_Homo sapiens_hsa054160.85251231
57Starch and sucrose metabolism_Homo sapiens_hsa005000.84087662
58Non-small cell lung cancer_Homo sapiens_hsa052230.83500406
59Nitrogen metabolism_Homo sapiens_hsa009100.82686398
60Amoebiasis_Homo sapiens_hsa051460.82416251
61PPAR signaling pathway_Homo sapiens_hsa033200.80857178
62Selenocompound metabolism_Homo sapiens_hsa004500.80592549
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80092492
64Lysine degradation_Homo sapiens_hsa003100.79194131
65Renal cell carcinoma_Homo sapiens_hsa052110.79087465
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.78581966
67Pancreatic cancer_Homo sapiens_hsa052120.78385393
68Insulin resistance_Homo sapiens_hsa049310.75889177
69Chemokine signaling pathway_Homo sapiens_hsa040620.75882140
70Rheumatoid arthritis_Homo sapiens_hsa053230.74734993
71Arginine biosynthesis_Homo sapiens_hsa002200.74579121
72Tryptophan metabolism_Homo sapiens_hsa003800.74560094
73Phagosome_Homo sapiens_hsa041450.74540707
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72398351
75Platelet activation_Homo sapiens_hsa046110.72348246
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.71579998
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71079982
78Type I diabetes mellitus_Homo sapiens_hsa049400.69951205
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.68576815
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.67936631
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67759397
82Fatty acid degradation_Homo sapiens_hsa000710.67460556
83Prolactin signaling pathway_Homo sapiens_hsa049170.66943386
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66165802
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64062069
86Notch signaling pathway_Homo sapiens_hsa043300.63086673
87Viral carcinogenesis_Homo sapiens_hsa052030.63057013
88One carbon pool by folate_Homo sapiens_hsa006700.62428334
89mTOR signaling pathway_Homo sapiens_hsa041500.61170175
90Proteoglycans in cancer_Homo sapiens_hsa052050.60882298
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60831991
92Chemical carcinogenesis_Homo sapiens_hsa052040.60601634
93Histidine metabolism_Homo sapiens_hsa003400.60234261
94Dorso-ventral axis formation_Homo sapiens_hsa043200.60107121
95Sphingolipid metabolism_Homo sapiens_hsa006000.57991097
96p53 signaling pathway_Homo sapiens_hsa041150.57248512
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55961642
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55720807
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55323087
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.55176035
101Endometrial cancer_Homo sapiens_hsa052130.55059178
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54743162
103Renin-angiotensin system_Homo sapiens_hsa046140.54619952
104* Epstein-Barr virus infection_Homo sapiens_hsa051690.54256769
105HIF-1 signaling pathway_Homo sapiens_hsa040660.53941017
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.53369302
107Endocytosis_Homo sapiens_hsa041440.53078465
108FoxO signaling pathway_Homo sapiens_hsa040680.52949599
109Vitamin digestion and absorption_Homo sapiens_hsa049770.52886941
110Pentose phosphate pathway_Homo sapiens_hsa000300.52860350
111Prostate cancer_Homo sapiens_hsa052150.52826519
112Autoimmune thyroid disease_Homo sapiens_hsa053200.52213508
113ErbB signaling pathway_Homo sapiens_hsa040120.51938540
114HTLV-I infection_Homo sapiens_hsa051660.51875889
115Folate biosynthesis_Homo sapiens_hsa007900.50744707
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50578169
117Peroxisome_Homo sapiens_hsa041460.48734518
118Type II diabetes mellitus_Homo sapiens_hsa049300.48555349
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48335678
120Focal adhesion_Homo sapiens_hsa045100.48157631
121MicroRNAs in cancer_Homo sapiens_hsa052060.47302608
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.45970188
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43585226
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43500934
125Choline metabolism in cancer_Homo sapiens_hsa052310.43321331
126Insulin signaling pathway_Homo sapiens_hsa049100.42386149
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40870715
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40534189
129Thyroid cancer_Homo sapiens_hsa052160.38453920
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38086678
131Galactose metabolism_Homo sapiens_hsa000520.36384477
132Glioma_Homo sapiens_hsa052140.36319262

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