Rank | Gene Set | Z-score |
---|---|---|
1 | neutrophil activation involved in immune response (GO:0002283) | 4.95665203 |
2 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.81252185 |
3 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.81252185 |
4 | modulation by symbiont of host immune response (GO:0052553) | 4.81252185 |
5 | positive regulation by symbiont of host defense response (GO:0052509) | 4.81252185 |
6 | modulation by symbiont of host defense response (GO:0052031) | 4.81252185 |
7 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.81252185 |
8 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.75058710 |
9 | * positive regulation of interferon-alpha production (GO:0032727) | 4.62765145 |
10 | * regulation of interferon-alpha production (GO:0032647) | 4.41149994 |
11 | positive regulation of chemokine biosynthetic process (GO:0045080) | 4.22158767 |
12 | * response to peptidoglycan (GO:0032494) | 4.02462649 |
13 | * lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.98114999 |
14 | * regulation of T-helper 1 cell differentiation (GO:0045625) | 3.95234633 |
15 | cellular response to type I interferon (GO:0071357) | 3.93579078 |
16 | type I interferon signaling pathway (GO:0060337) | 3.93579078 |
17 | granulocyte activation (GO:0036230) | 3.89802133 |
18 | immunoglobulin mediated immune response (GO:0016064) | 3.89410353 |
19 | eosinophil chemotaxis (GO:0048245) | 3.89357792 |
20 | response to type I interferon (GO:0034340) | 3.89333083 |
21 | positive regulation of heat generation (GO:0031652) | 3.77673381 |
22 | regulation of fever generation (GO:0031620) | 3.66151314 |
23 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.65188937 |
24 | cellular response to interferon-beta (GO:0035458) | 3.64357616 |
25 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.61163210 |
26 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.61152852 |
27 | T cell migration (GO:0072678) | 3.60842615 |
28 | NIK/NF-kappaB signaling (GO:0038061) | 3.56984522 |
29 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.55817719 |
30 | natural killer cell mediated immunity (GO:0002228) | 3.55817719 |
31 | positive regulation of natural killer cell differentiation (GO:0032825) | 3.55758034 |
32 | macrophage activation involved in immune response (GO:0002281) | 3.55285420 |
33 | cellular response to exogenous dsRNA (GO:0071360) | 3.54486764 |
34 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.52574707 |
35 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.51109222 |
36 | response to interferon-alpha (GO:0035455) | 3.50149324 |
37 | cellular response to virus (GO:0098586) | 3.48491873 |
38 | eosinophil migration (GO:0072677) | 3.47689344 |
39 | response to protozoan (GO:0001562) | 3.43211548 |
40 | regulation of chemokine biosynthetic process (GO:0045073) | 3.43148249 |
41 | cellular response to interferon-alpha (GO:0035457) | 3.42498584 |
42 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.37990482 |
43 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.37170087 |
44 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.37170087 |
45 | monocyte chemotaxis (GO:0002548) | 3.35273227 |
46 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.34664106 |
47 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.33157463 |
48 | * positive regulation of interferon-beta production (GO:0032728) | 3.32181933 |
49 | response to interferon-beta (GO:0035456) | 3.31710255 |
50 | neutrophil activation (GO:0042119) | 3.30067411 |
51 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.30036856 |
52 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.29446255 |
53 | * response to muramyl dipeptide (GO:0032495) | 3.25969954 |
54 | T-helper 1 type immune response (GO:0042088) | 3.24973169 |
55 | regulation of chronic inflammatory response (GO:0002676) | 3.24264473 |
56 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.24054746 |
57 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.23490742 |
58 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.22484576 |
59 | negative regulation of viral genome replication (GO:0045071) | 3.21766992 |
60 | * positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.21239682 |
61 | regulation of growth of symbiont in host (GO:0044126) | 3.20982905 |
62 | negative regulation of growth of symbiont in host (GO:0044130) | 3.20982905 |
63 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 3.20982905 |
64 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 3.20982905 |
65 | response to host immune response (GO:0052572) | 3.19855412 |
66 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.19855412 |
67 | * positive regulation of interleukin-12 production (GO:0032735) | 3.19435094 |
68 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 3.17312377 |
69 | lymphocyte chemotaxis (GO:0048247) | 3.16360808 |
70 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.16234030 |
71 | regulation of mononuclear cell migration (GO:0071675) | 3.13726195 |
72 | myeloid dendritic cell differentiation (GO:0043011) | 3.11643647 |
73 | B cell mediated immunity (GO:0019724) | 3.11203208 |
74 | regulation of cytokine secretion involved in immune response (GO:0002739) | 3.06736441 |
75 | myeloid cell activation involved in immune response (GO:0002275) | 3.06514139 |
76 | regulation of podosome assembly (GO:0071801) | 3.05715586 |
77 | germinal center formation (GO:0002467) | 3.04714310 |
78 | respiratory burst (GO:0045730) | 3.03355796 |
79 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 3.02957668 |
80 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 3.02431600 |
81 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 3.00819209 |
82 | * positive regulation of T-helper cell differentiation (GO:0045624) | 2.99993986 |
83 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.99538691 |
84 | * regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 2.99126850 |
85 | positive regulation of cytokine biosynthetic process (GO:0042108) | 2.97954712 |
86 | positive regulation of interleukin-17 production (GO:0032740) | 2.97359955 |
87 | positive regulation of antigen processing and presentation (GO:0002579) | 2.94187158 |
88 | * regulation of T-helper cell differentiation (GO:0045622) | 2.93461853 |
89 | regulation of NF-kappaB import into nucleus (GO:0042345) | 2.92737249 |
90 | response to host (GO:0075136) | 2.92363979 |
91 | response to host defenses (GO:0052200) | 2.92363979 |
92 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.92363979 |
93 | positive regulation of interleukin-10 production (GO:0032733) | 2.92107135 |
94 | regulation of RIG-I signaling pathway (GO:0039535) | 2.91431255 |
95 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.90448848 |
96 | * positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) | 2.90225504 |
97 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.89250488 |
98 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.89024057 |
99 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.88387787 |
100 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.88199313 |
101 | * positive regulation of interleukin-6 production (GO:0032755) | 2.87769086 |
102 | * cellular response to lipopolysaccharide (GO:0071222) | 2.87031061 |
103 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.86197934 |
104 | myeloid dendritic cell activation (GO:0001773) | 2.86035671 |
105 | positive regulation of nitric oxide biosynthetic process (GO:0045429) | 2.85566843 |
106 | cellular response to interferon-gamma (GO:0071346) | 2.85428545 |
107 | positive regulation of acute inflammatory response (GO:0002675) | 2.85018576 |
108 | detection of molecule of bacterial origin (GO:0032490) | 2.84480434 |
109 | defense response to protozoan (GO:0042832) | 2.84275456 |
110 | leukocyte aggregation (GO:0070486) | 2.82876140 |
111 | regulation of activation of Janus kinase activity (GO:0010533) | 2.82724050 |
112 | * cellular response to molecule of bacterial origin (GO:0071219) | 2.81371927 |
113 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.80689364 |
114 | * positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.80490363 |
115 | regulation of antigen processing and presentation (GO:0002577) | 2.79768135 |
116 | positive regulation of type 2 immune response (GO:0002830) | 2.79351449 |
117 | regulation of interleukin-1 beta secretion (GO:0050706) | 2.78827853 |
118 | regulation of vitamin metabolic process (GO:0030656) | 2.78791104 |
119 | * positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.78505421 |
120 | negative regulation of interleukin-12 production (GO:0032695) | 2.77760914 |
121 | positive regulation of monocyte chemotaxis (GO:0090026) | 2.77490561 |
122 | * regulation of interleukin-12 production (GO:0032655) | 2.76732582 |
123 | * positive regulation of tumor necrosis factor production (GO:0032760) | 2.76523740 |
124 | regulation of interleukin-17 production (GO:0032660) | 2.76466794 |
125 | regulation of nitric oxide biosynthetic process (GO:0045428) | 2.76332779 |
126 | regulation of heat generation (GO:0031650) | 2.76313821 |
127 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.76134458 |
128 | * regulation of alpha-beta T cell proliferation (GO:0046640) | 2.76073347 |
129 | regulation of interferon-gamma biosynthetic process (GO:0045072) | 2.72212592 |
130 | response to interferon-gamma (GO:0034341) | 2.72191372 |
131 | positive regulation of defense response to virus by host (GO:0002230) | 2.71960626 |
132 | positive regulation of interleukin-1 secretion (GO:0050716) | 2.71716538 |
133 | regulation of inflammatory response to antigenic stimulus (GO:0002861) | 2.71316281 |
134 | myeloid cell homeostasis (GO:0002262) | 2.70390892 |
135 | positive regulation of macrophage differentiation (GO:0045651) | 2.70220934 |
136 | * regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.68845503 |
137 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 2.68288480 |
138 | histamine secretion (GO:0001821) | 2.68204321 |
139 | regulation of B cell apoptotic process (GO:0002902) | 2.67253075 |
140 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 2.66530345 |
141 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 2.65397764 |
142 | negative regulation of lipid storage (GO:0010888) | 2.63101748 |
143 | mature B cell differentiation involved in immune response (GO:0002313) | 2.59169739 |
144 | negative regulation of production of molecular mediator of immune response (GO:0002701) | 2.58670633 |
145 | macrophage activation (GO:0042116) | 2.57222670 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.84616888 |
2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 6.18703822 |
3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.90847677 |
4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.33574640 |
5 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.14678902 |
6 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.01831012 |
7 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.96273431 |
8 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.76748383 |
9 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.48472665 |
10 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 3.47275336 |
11 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.31247650 |
12 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.11164806 |
13 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.99838033 |
14 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.93310213 |
15 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.89516605 |
16 | * NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.88090414 |
17 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.72296704 |
18 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.70571987 |
19 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.66964324 |
20 | * STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.54111476 |
21 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.02298478 |
22 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.99046908 |
23 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.97577250 |
24 | MYB_26560356_Chip-Seq_TH2_Human | 1.85200563 |
25 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.82067675 |
26 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.80270342 |
27 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.74120965 |
28 | MAF_26560356_Chip-Seq_TH1_Human | 1.74096651 |
29 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.71394560 |
30 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.68965367 |
31 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.62699144 |
32 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.62118288 |
33 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.57645992 |
34 | MYB_26560356_Chip-Seq_TH1_Human | 1.54792310 |
35 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.53198038 |
36 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.53198038 |
37 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.53198038 |
38 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.51008030 |
39 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.50003792 |
40 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.48732221 |
41 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48516596 |
42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.48359611 |
43 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.45557123 |
44 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.44801854 |
45 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.44789535 |
46 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.44341377 |
47 | GATA1_22025678_ChIP-Seq_K562_Human | 1.43758803 |
48 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.42405085 |
49 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.42080353 |
50 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.39705667 |
51 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.38165331 |
52 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.35193301 |
53 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.34261519 |
54 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.33078193 |
55 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.32761862 |
56 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.32607747 |
57 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.28936664 |
58 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.28129863 |
59 | SPI1_23127762_ChIP-Seq_K562_Human | 1.27967512 |
60 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27006503 |
61 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.24913254 |
62 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20624484 |
63 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.19527030 |
64 | UTX_26944678_Chip-Seq_JUKART_Human | 1.16090066 |
65 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.14802824 |
66 | * CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.13430281 |
67 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.13387431 |
68 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.13387431 |
69 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.11838036 |
70 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.10878846 |
71 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.09562752 |
72 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.09357025 |
73 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.09274726 |
74 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.08327281 |
75 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.06392388 |
76 | MYC_22102868_ChIP-Seq_BL_Human | 1.06277938 |
77 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.05511862 |
78 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.05398987 |
79 | GATA3_26560356_Chip-Seq_TH2_Human | 1.05339520 |
80 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.04906532 |
81 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.03691848 |
82 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02760494 |
83 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.02687115 |
84 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.02218689 |
85 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.01507949 |
86 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.99929958 |
87 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.99797748 |
88 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.99414849 |
89 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.95739021 |
90 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.95455333 |
91 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94833826 |
92 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.92887954 |
93 | MAF_26560356_Chip-Seq_TH2_Human | 0.92809335 |
94 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.91990653 |
95 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.89758923 |
96 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89182170 |
97 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.88517790 |
98 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.86713240 |
99 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.86713240 |
100 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.86239874 |
101 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.85995048 |
102 | ATF3_27146783_Chip-Seq_COLON_Human | 0.85386726 |
103 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.85195010 |
104 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.85038187 |
105 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.83539988 |
106 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.82823624 |
107 | CJUN_26792858_Chip-Seq_BT549_Human | 0.82357217 |
108 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.81230394 |
109 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.81145411 |
110 | * FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.80266527 |
111 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 0.79937444 |
112 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.79695419 |
113 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.79421675 |
114 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.79387369 |
115 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.76411858 |
116 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.74031046 |
117 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.72785978 |
118 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.72551887 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001835_abnormal_antigen_presentation | 4.05974552 |
2 | MP0009785_altered_susceptibility_to | 3.84233700 |
3 | MP0003436_decreased_susceptibility_to | 3.66173419 |
4 | MP0006082_CNS_inflammation | 3.38623688 |
5 | MP0002148_abnormal_hypersensitivity_rea | 3.38487244 |
6 | MP0003303_peritoneal_inflammation | 3.14004473 |
7 | MP0005000_abnormal_immune_tolerance | 3.07518247 |
8 | MP0000685_abnormal_immune_system | 3.05466700 |
9 | MP0003724_increased_susceptibility_to | 2.81880451 |
10 | MP0001790_abnormal_immune_system | 2.76393228 |
11 | MP0005387_immune_system_phenotype | 2.76393228 |
12 | * MP0002419_abnormal_innate_immunity | 2.75470139 |
13 | * MP0005025_abnormal_response_to | 2.75107193 |
14 | * MP0002452_abnormal_antigen_presenting | 2.49762867 |
15 | MP0005671_abnormal_response_to | 2.45783042 |
16 | * MP0001800_abnormal_humoral_immune | 2.45092982 |
17 | * MP0002723_abnormal_immune_serum | 2.43589801 |
18 | MP0004510_myositis | 2.42408393 |
19 | MP0001533_abnormal_skeleton_physiology | 2.16936854 |
20 | MP0004947_skin_inflammation | 2.14655752 |
21 | * MP0001819_abnormal_immune_cell | 2.09562952 |
22 | MP0001853_heart_inflammation | 2.09195995 |
23 | * MP0002420_abnormal_adaptive_immunity | 2.06371843 |
24 | MP0003806_abnormal_nucleotide_metabolis | 2.03034816 |
25 | MP0002006_tumorigenesis | 2.00208597 |
26 | MP0009764_decreased_sensitivity_to | 1.96175738 |
27 | MP0008438_abnormal_cutaneous_collagen | 1.95828790 |
28 | MP0002405_respiratory_system_inflammati | 1.88632960 |
29 | MP0003448_altered_tumor_morphology | 1.86352040 |
30 | MP0001845_abnormal_inflammatory_respons | 1.79917815 |
31 | MP0005464_abnormal_platelet_physiology | 1.79119115 |
32 | MP0009333_abnormal_splenocyte_physiolog | 1.76191803 |
33 | MP0000343_altered_response_to | 1.74545731 |
34 | MP0010352_gastrointestinal_tract_polyps | 1.73852188 |
35 | MP0010155_abnormal_intestine_physiology | 1.73011101 |
36 | MP0000858_altered_metastatic_potential | 1.72843688 |
37 | MP0005058_abnormal_lysosome_morphology | 1.68753401 |
38 | MP0008469_abnormal_protein_level | 1.65408983 |
39 | MP0003300_gastrointestinal_ulcer | 1.61830786 |
40 | MP0003656_abnormal_erythrocyte_physiolo | 1.58650825 |
41 | * MP0002398_abnormal_bone_marrow | 1.56169166 |
42 | * MP0000716_abnormal_immune_system | 1.56007705 |
43 | MP0009278_abnormal_bone_marrow | 1.53745162 |
44 | MP0005397_hematopoietic_system_phenotyp | 1.50676826 |
45 | MP0001545_abnormal_hematopoietic_system | 1.50676826 |
46 | MP0002166_altered_tumor_susceptibility | 1.50014384 |
47 | MP0002998_abnormal_bone_remodeling | 1.45268036 |
48 | MP0003705_abnormal_hypodermis_morpholog | 1.34918778 |
49 | MP0003195_calcinosis | 1.34318661 |
50 | MP0000689_abnormal_spleen_morphology | 1.28410117 |
51 | * MP0002429_abnormal_blood_cell | 1.26861761 |
52 | MP0003453_abnormal_keratinocyte_physiol | 1.24548320 |
53 | MP0002722_abnormal_immune_system | 1.22890866 |
54 | MP0003566_abnormal_cell_adhesion | 1.22738201 |
55 | MP0005390_skeleton_phenotype | 1.21493094 |
56 | MP0003091_abnormal_cell_migration | 1.21197292 |
57 | MP0002332_abnormal_exercise_endurance | 1.21046648 |
58 | MP0002139_abnormal_hepatobiliary_system | 1.19567868 |
59 | MP0003950_abnormal_plasma_membrane | 1.19516064 |
60 | MP0005023_abnormal_wound_healing | 1.19502709 |
61 | MP0003279_aneurysm | 1.18889737 |
62 | MP0005310_abnormal_salivary_gland | 1.17825286 |
63 | MP0003075_altered_response_to | 1.16998634 |
64 | MP0005451_abnormal_body_composition | 1.15552667 |
65 | MP0005076_abnormal_cell_differentiation | 1.14803659 |
66 | MP0009840_abnormal_foam_cell | 1.12843641 |
67 | MP0002933_joint_inflammation | 1.11769639 |
68 | MP0005164_abnormal_response_to | 1.11665291 |
69 | MP0002138_abnormal_hepatobiliary_system | 1.10567290 |
70 | MP0009763_increased_sensitivity_to | 1.10001414 |
71 | MP0003763_abnormal_thymus_physiology | 1.09577844 |
72 | MP0003186_abnormal_redox_activity | 1.08695146 |
73 | MP0010307_abnormal_tumor_latency | 1.06406896 |
74 | MP0004808_abnormal_hematopoietic_stem | 1.05294958 |
75 | MP0005166_decreased_susceptibility_to | 1.01079532 |
76 | MP0001851_eye_inflammation | 1.00021749 |
77 | MP0002877_abnormal_melanocyte_morpholog | 0.95040383 |
78 | MP0005165_increased_susceptibility_to | 0.93384558 |
79 | MP0001958_emphysema | 0.91374249 |
80 | MP0003828_pulmonary_edema | 0.91028614 |
81 | MP0002254_reproductive_system_inflammat | 0.88470979 |
82 | MP0008260_abnormal_autophagy | 0.87563816 |
83 | MP0000767_abnormal_smooth_muscle | 0.86530759 |
84 | MP0009765_abnormal_xenobiotic_induced | 0.85648126 |
85 | MP0000249_abnormal_blood_vessel | 0.84703245 |
86 | MP0000490_abnormal_crypts_of | 0.84481683 |
87 | MP0003172_abnormal_lysosome_physiology | 0.83889298 |
88 | MP0000604_amyloidosis | 0.81495443 |
89 | MP0000569_abnormal_digit_pigmentation | 0.81262852 |
90 | MP0000465_gastrointestinal_hemorrhage | 0.80499541 |
91 | MP0001348_abnormal_lacrimal_gland | 0.78447134 |
92 | MP0005275_abnormal_skin_tensile | 0.77918399 |
93 | MP0003795_abnormal_bone_structure | 0.77529752 |
94 | MP0000703_abnormal_thymus_morphology | 0.77130485 |
95 | MP0004883_abnormal_blood_vessel | 0.75760577 |
96 | MP0001542_abnormal_bone_strength | 0.73785745 |
97 | MP0002396_abnormal_hematopoietic_system | 0.72291600 |
98 | MP0001243_abnormal_dermal_layer | 0.71521802 |
99 | MP0009697_abnormal_copulation | 0.70255931 |
100 | MP0001216_abnormal_epidermal_layer | 0.68406549 |
101 | MP0001191_abnormal_skin_condition | 0.67839359 |
102 | MP0005647_abnormal_sex_gland | 0.66186488 |
103 | MP0002132_abnormal_respiratory_system | 0.65398310 |
104 | MP0001663_abnormal_digestive_system | 0.65218174 |
105 | MP0008057_abnormal_DNA_replication | 0.64768875 |
106 | MP0006054_spinal_hemorrhage | 0.64670776 |
107 | MP0001881_abnormal_mammary_gland | 0.64032899 |
108 | MP0005167_abnormal_blood-brain_barrier | 0.63816580 |
109 | MP0003191_abnormal_cellular_cholesterol | 0.63472610 |
110 | MP0008007_abnormal_cellular_replicative | 0.63246289 |
111 | MP0002019_abnormal_tumor_incidence | 0.60826133 |
112 | MP0001915_intracranial_hemorrhage | 0.60037699 |
113 | MP0002136_abnormal_kidney_physiology | 0.58499069 |
114 | MP0000371_diluted_coat_color | 0.58481829 |
115 | MP0001873_stomach_inflammation | 0.58267640 |
116 | MP0000733_abnormal_muscle_development | 0.57571052 |
117 | MP0003045_fibrosis | 0.53559907 |
118 | MP0008004_abnormal_stomach_pH | 0.53232549 |
119 | MP0004782_abnormal_surfactant_physiolog | 0.52848104 |
120 | MP0002277_abnormal_respiratory_mucosa | 0.52060396 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Eczematoid dermatitis (HP:0000976) | 5.45565967 |
2 | Recurrent abscess formation (HP:0002722) | 5.34101834 |
3 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.20251734 |
4 | Recurrent bacterial skin infections (HP:0005406) | 5.18846982 |
5 | Abnormality of glycolipid metabolism (HP:0010969) | 5.17120719 |
6 | Abnormality of liposaccharide metabolism (HP:0010968) | 5.17120719 |
7 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 5.17120719 |
8 | Mediastinal lymphadenopathy (HP:0100721) | 4.39957372 |
9 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.38290953 |
10 | Myositis (HP:0100614) | 4.32580723 |
11 | Orchitis (HP:0100796) | 4.15040264 |
12 | Autoimmune thrombocytopenia (HP:0001973) | 3.91815251 |
13 | Retrobulbar optic neuritis (HP:0100654) | 3.82656827 |
14 | Optic neuritis (HP:0100653) | 3.82656827 |
15 | Abnormality of macrophages (HP:0004311) | 3.74476696 |
16 | Loss of speech (HP:0002371) | 3.74384381 |
17 | Systemic lupus erythematosus (HP:0002725) | 3.61846042 |
18 | Vasculitis (HP:0002633) | 3.56986329 |
19 | Recurrent skin infections (HP:0001581) | 3.47353914 |
20 | Recurrent fungal infections (HP:0002841) | 3.47299253 |
21 | Stomatitis (HP:0010280) | 3.47271038 |
22 | Vacuolated lymphocytes (HP:0001922) | 3.46654516 |
23 | Vertebral compression fractures (HP:0002953) | 3.42381397 |
24 | Peritonitis (HP:0002586) | 3.39907383 |
25 | Amyloidosis (HP:0011034) | 3.35380470 |
26 | Basal ganglia calcification (HP:0002135) | 3.31093415 |
27 | Increased IgM level (HP:0003496) | 3.18896243 |
28 | Recurrent viral infections (HP:0004429) | 3.17651828 |
29 | Increased serum ferritin (HP:0003281) | 3.01480229 |
30 | Gingivitis (HP:0000230) | 2.92238844 |
31 | Encephalitis (HP:0002383) | 2.90180805 |
32 | Osteolytic defects of the hand bones (HP:0009699) | 2.84849736 |
33 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.84849736 |
34 | Pulmonary infiltrates (HP:0002113) | 2.83929641 |
35 | Tetraparesis (HP:0002273) | 2.83038419 |
36 | Pustule (HP:0200039) | 2.82110704 |
37 | Myocardial infarction (HP:0001658) | 2.81049092 |
38 | Increased cerebral lipofuscin (HP:0011813) | 2.79202442 |
39 | Cellulitis (HP:0100658) | 2.76454183 |
40 | Recurrent cutaneous fungal infections (HP:0011370) | 2.75702400 |
41 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.75702400 |
42 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.75488331 |
43 | Periodontitis (HP:0000704) | 2.74458585 |
44 | Interstitial pulmonary disease (HP:0006530) | 2.71354316 |
45 | Prostate neoplasm (HP:0100787) | 2.65761693 |
46 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.62091938 |
47 | Leukocytosis (HP:0001974) | 2.57819600 |
48 | Hypergammaglobulinemia (HP:0010702) | 2.55592172 |
49 | Abnormality of iron homeostasis (HP:0011031) | 2.54333690 |
50 | Chronic otitis media (HP:0000389) | 2.52124648 |
51 | Arterial thrombosis (HP:0004420) | 2.49518230 |
52 | Axonal loss (HP:0003447) | 2.49061539 |
53 | Obstructive lung disease (HP:0006536) | 2.47590169 |
54 | Chronic obstructive pulmonary disease (HP:0006510) | 2.47590169 |
55 | Abnormality of B cell number (HP:0010975) | 2.46927110 |
56 | Protrusio acetabuli (HP:0003179) | 2.44933563 |
57 | Urticaria (HP:0001025) | 2.44143871 |
58 | B lymphocytopenia (HP:0010976) | 2.43270884 |
59 | Gastrointestinal infarctions (HP:0005244) | 2.40145811 |
60 | Abnormality of the prostate (HP:0008775) | 2.38873009 |
61 | Polyneuropathy (HP:0001271) | 2.38676424 |
62 | Amaurosis fugax (HP:0100576) | 2.36836240 |
63 | Nasal polyposis (HP:0100582) | 2.36517825 |
64 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.34799231 |
65 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.34799231 |
66 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.34799231 |
67 | Panhypogammaglobulinemia (HP:0003139) | 2.34590910 |
68 | Thick nail (HP:0001805) | 2.31867607 |
69 | Episodic fever (HP:0001954) | 2.31486340 |
70 | Recurrent pneumonia (HP:0006532) | 2.29731134 |
71 | Poor head control (HP:0002421) | 2.28927641 |
72 | Porencephaly (HP:0002132) | 2.26871448 |
73 | Mutism (HP:0002300) | 2.25636425 |
74 | Osteomyelitis (HP:0002754) | 2.25291331 |
75 | Premature rupture of membranes (HP:0001788) | 2.23009407 |
76 | Glomerulonephritis (HP:0000099) | 2.22712775 |
77 | Recurrent bronchitis (HP:0002837) | 2.22318752 |
78 | Hemoptysis (HP:0002105) | 2.21959726 |
79 | Alveolar cell carcinoma (HP:0006519) | 2.20976824 |
80 | Disinhibition (HP:0000734) | 2.19699629 |
81 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.19654511 |
82 | Abnormality of the nasal mucosa (HP:0000433) | 2.19401854 |
83 | Emphysema (HP:0002097) | 2.19197358 |
84 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.18478085 |
85 | Mucopolysacchariduria (HP:0008155) | 2.18478085 |
86 | Hepatosplenomegaly (HP:0001433) | 2.16608732 |
87 | Neoplasm of head and neck (HP:0012288) | 2.16447620 |
88 | Esophageal neoplasm (HP:0100751) | 2.16447620 |
89 | Fatigue (HP:0012378) | 2.16195639 |
90 | Impaired platelet aggregation (HP:0003540) | 2.15815106 |
91 | Abnormal platelet function (HP:0011869) | 2.15815106 |
92 | Premature loss of primary teeth (HP:0006323) | 2.15386709 |
93 | Hematochezia (HP:0002573) | 2.14235598 |
94 | Petechiae (HP:0000967) | 2.12564331 |
95 | Recurrent lower respiratory tract infections (HP:0002783) | 2.12180594 |
96 | Prolonged bleeding time (HP:0003010) | 2.11691492 |
97 | Thrombocytosis (HP:0001894) | 2.10703371 |
98 | Gingival bleeding (HP:0000225) | 2.10464905 |
99 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.09758393 |
100 | Abnormality of the pericardium (HP:0001697) | 2.09217307 |
101 | Keratoconjunctivitis sicca (HP:0001097) | 2.09206558 |
102 | Eosinophilia (HP:0001880) | 2.07638141 |
103 | Anorexia (HP:0002039) | 2.04058514 |
104 | Arthralgia (HP:0002829) | 2.03677895 |
105 | Epistaxis (HP:0000421) | 2.02265035 |
106 | Meningitis (HP:0001287) | 2.02043486 |
107 | Dysostosis multiplex (HP:0000943) | 2.00746423 |
108 | Abnormality of T cell number (HP:0011839) | 1.99813581 |
109 | Vertigo (HP:0002321) | 1.99491757 |
110 | T lymphocytopenia (HP:0005403) | 1.98144388 |
111 | Pathologic fracture (HP:0002756) | 1.98003622 |
112 | Abnormality of T cell physiology (HP:0011840) | 1.97826635 |
113 | Viral hepatitis (HP:0006562) | 1.97087741 |
114 | Gastrointestinal stroma tumor (HP:0100723) | 1.96680021 |
115 | Abnormality of the pleura (HP:0002103) | 1.96041220 |
116 | Nephritis (HP:0000123) | 1.94837801 |
117 | Biconcave vertebral bodies (HP:0004586) | 1.93364845 |
118 | Nuclear cataract (HP:0100018) | 1.92701154 |
119 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.92383167 |
120 | Albinism (HP:0001022) | 1.92255152 |
121 | Skin ulcer (HP:0200042) | 1.91831109 |
122 | Keratoconjunctivitis (HP:0001096) | 1.91115572 |
123 | Colitis (HP:0002583) | 1.90396499 |
124 | Chest pain (HP:0100749) | 1.90297137 |
125 | Increased density of long bones (HP:0006392) | 1.89235639 |
126 | Abnormality of T cells (HP:0002843) | 1.86761433 |
127 | Hydroxyprolinuria (HP:0003080) | 1.86657960 |
128 | Abnormality of proline metabolism (HP:0010907) | 1.86657960 |
129 | Spondylolisthesis (HP:0003302) | 1.86622706 |
130 | Polygenic inheritance (HP:0010982) | 1.86102905 |
131 | Glomerulopathy (HP:0100820) | 1.85876984 |
132 | Keratitis (HP:0000491) | 1.85608559 |
133 | Joint swelling (HP:0001386) | 1.85471874 |
134 | IgA deficiency (HP:0002720) | 1.84335210 |
135 | Hypertensive crisis (HP:0100735) | 1.82884251 |
136 | Autoimmune hemolytic anemia (HP:0001890) | 1.82864372 |
137 | Bone pain (HP:0002653) | 1.80888352 |
138 | Parakeratosis (HP:0001036) | 1.79916889 |
139 | Dilatation of the ascending aorta (HP:0005111) | 1.78371321 |
140 | Granulocytopenia (HP:0001913) | 1.78197742 |
141 | Purpura (HP:0000979) | 1.76703565 |
142 | Agnosia (HP:0010524) | 1.75090975 |
143 | Gangrene (HP:0100758) | 1.74119133 |
144 | Spinal cord lesions (HP:0100561) | 1.73808694 |
145 | Syringomyelia (HP:0003396) | 1.73808694 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAP3K14 | 4.36323645 |
2 | TBK1 | 3.60922048 |
3 | TYK2 | 3.39700929 |
4 | BLK | 3.25442537 |
5 | IRAK3 | 3.18932583 |
6 | JAK3 | 2.91253608 |
7 | PIM2 | 2.91054262 |
8 | IKBKE | 2.77263591 |
9 | PBK | 2.69844050 |
10 | EIF2AK3 | 2.67559324 |
11 | IKBKB | 2.56465956 |
12 | MAP4K1 | 2.41592611 |
13 | ERN1 | 2.41104591 |
14 | RIPK4 | 2.36757970 |
15 | IRAK4 | 2.28436919 |
16 | SIK3 | 2.24540606 |
17 | KIT | 2.08897951 |
18 | TXK | 2.00359840 |
19 | JAK1 | 2.00030492 |
20 | GRK7 | 1.98132074 |
21 | NME2 | 1.95524543 |
22 | RPS6KA4 | 1.91046890 |
23 | CHUK | 1.72229860 |
24 | MAP3K13 | 1.69794501 |
25 | NEK9 | 1.50457674 |
26 | ZAP70 | 1.42997362 |
27 | FGFR4 | 1.41270141 |
28 | BCKDK | 1.37251738 |
29 | TESK1 | 1.35156517 |
30 | STK10 | 1.30265630 |
31 | PIM1 | 1.27446261 |
32 | CSK | 1.27280869 |
33 | MAP2K3 | 1.24903915 |
34 | CDK8 | 1.23687029 |
35 | MST4 | 1.23625519 |
36 | PRPF4B | 1.21179723 |
37 | BMX | 1.16749545 |
38 | IRAK2 | 1.15909682 |
39 | MAP3K3 | 1.13131417 |
40 | FGFR3 | 1.12291437 |
41 | ABL2 | 1.12023768 |
42 | CSF1R | 1.11436121 |
43 | MARK3 | 1.10563180 |
44 | TRPM7 | 1.08137273 |
45 | HCK | 1.07307257 |
46 | TAOK3 | 1.03770374 |
47 | EPHB1 | 1.02550272 |
48 | BTK | 1.01902538 |
49 | SYK | 1.01223376 |
50 | LCK | 1.01155444 |
51 | BMPR1B | 1.01092672 |
52 | FLT3 | 0.97889569 |
53 | TEC | 0.96664360 |
54 | MAP3K5 | 0.96336341 |
55 | BMPR2 | 0.96275803 |
56 | JAK2 | 0.93380662 |
57 | EPHA3 | 0.91326879 |
58 | EIF2AK1 | 0.90316548 |
59 | LYN | 0.89585079 |
60 | MOS | 0.88028778 |
61 | TTN | 0.85473926 |
62 | TGFBR2 | 0.85432968 |
63 | TESK2 | 0.84602600 |
64 | MAP3K12 | 0.82677549 |
65 | MAP3K1 | 0.82270556 |
66 | PIK3CG | 0.79840121 |
67 | TAOK1 | 0.78509830 |
68 | TAOK2 | 0.77099438 |
69 | PDK2 | 0.77033759 |
70 | ADRBK2 | 0.75492050 |
71 | EIF2AK2 | 0.75423559 |
72 | CDK6 | 0.75190261 |
73 | LRRK2 | 0.74003137 |
74 | TGFBR1 | 0.73125497 |
75 | STK4 | 0.73117421 |
76 | ARAF | 0.72975677 |
77 | FES | 0.70116698 |
78 | MAP3K10 | 0.68822186 |
79 | ITK | 0.67962859 |
80 | FGR | 0.66515517 |
81 | MAP3K11 | 0.65990294 |
82 | DAPK3 | 0.65788786 |
83 | MATK | 0.64007573 |
84 | ABL1 | 0.63965921 |
85 | TRIB3 | 0.62753243 |
86 | CLK1 | 0.62565492 |
87 | ERBB3 | 0.62117847 |
88 | CAMK1D | 0.57316755 |
89 | STK3 | 0.56176673 |
90 | DYRK1B | 0.54044412 |
91 | KDR | 0.53366990 |
92 | RPS6KA5 | 0.52056369 |
93 | EGFR | 0.51504049 |
94 | DDR2 | 0.51133045 |
95 | BRSK2 | 0.50896892 |
96 | RIPK1 | 0.47059340 |
97 | SCYL2 | 0.47007958 |
98 | HIPK2 | 0.46598165 |
99 | MAP3K8 | 0.46072609 |
100 | IRAK1 | 0.45588360 |
101 | PTK6 | 0.44197987 |
102 | MAPKAPK2 | 0.44075710 |
103 | ERBB4 | 0.43105408 |
104 | GRK6 | 0.42690157 |
105 | YES1 | 0.42459162 |
106 | NLK | 0.42049474 |
107 | TNK2 | 0.42014618 |
108 | CDK9 | 0.41601194 |
109 | STK24 | 0.39945830 |
110 | CDK19 | 0.39877774 |
111 | PRKCD | 0.39716212 |
112 | MAPK7 | 0.38826343 |
113 | MST1R | 0.38361252 |
114 | BRD4 | 0.37381669 |
115 | NUAK1 | 0.33700161 |
116 | MKNK1 | 0.32698923 |
117 | LIMK1 | 0.31343781 |
118 | CDK12 | 0.30140008 |
119 | RAF1 | 0.30021871 |
120 | GSK3A | 0.28167766 |
121 | IGF1R | 0.27256141 |
122 | PAK4 | 0.25610293 |
123 | PRKCQ | 0.25073440 |
124 | INSR | 0.24482110 |
125 | BRAF | 0.24340492 |
126 | PAK1 | 0.24272884 |
127 | MAPKAPK3 | 0.23282631 |
128 | RPS6KC1 | 0.23258538 |
129 | RPS6KL1 | 0.23258538 |
130 | TRIM28 | 0.22984550 |
131 | AKT3 | 0.22500743 |
132 | PRKG2 | 0.21752207 |
133 | PAK2 | 0.19992882 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.48450428 |
2 | Leishmaniasis_Homo sapiens_hsa05140 | 3.25752329 |
3 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.86903547 |
4 | Allograft rejection_Homo sapiens_hsa05330 | 2.84711404 |
5 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.77928063 |
6 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.71590544 |
7 | Legionellosis_Homo sapiens_hsa05134 | 2.60883429 |
8 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.48724654 |
9 | * NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.48028806 |
10 | Malaria_Homo sapiens_hsa05144 | 2.43646088 |
11 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.34067430 |
12 | Measles_Homo sapiens_hsa05162 | 2.31428587 |
13 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.30841643 |
14 | Pertussis_Homo sapiens_hsa05133 | 2.26300157 |
15 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.23951363 |
16 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.18638655 |
17 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.14481423 |
18 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.10327616 |
19 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.99813094 |
20 | * Tuberculosis_Homo sapiens_hsa05152 | 1.93603013 |
21 | Influenza A_Homo sapiens_hsa05164 | 1.92203704 |
22 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.75256571 |
23 | Asthma_Homo sapiens_hsa05310 | 1.70490268 |
24 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.68957426 |
25 | Salmonella infection_Homo sapiens_hsa05132 | 1.66680031 |
26 | * Shigellosis_Homo sapiens_hsa05131 | 1.54304569 |
27 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.53985456 |
28 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.51957755 |
29 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.50104047 |
30 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.48473968 |
31 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.43409107 |
32 | Apoptosis_Homo sapiens_hsa04210 | 1.42547897 |
33 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.39357179 |
34 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.38803603 |
35 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.38317755 |
36 | Viral myocarditis_Homo sapiens_hsa05416 | 1.33595710 |
37 | Hepatitis B_Homo sapiens_hsa05161 | 1.30175296 |
38 | Phagosome_Homo sapiens_hsa04145 | 1.27066027 |
39 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.25617663 |
40 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.21767981 |
41 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.21369873 |
42 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.18340441 |
43 | Hepatitis C_Homo sapiens_hsa05160 | 1.10386893 |
44 | Lysosome_Homo sapiens_hsa04142 | 1.05612723 |
45 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.03316755 |
46 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.99240838 |
47 | Amoebiasis_Homo sapiens_hsa05146 | 0.96311077 |
48 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.91183121 |
49 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.86992003 |
50 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.84733956 |
51 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.84009061 |
52 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.81367273 |
53 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.80267938 |
54 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.79872630 |
55 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.78905487 |
56 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.76992777 |
57 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.76820505 |
58 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.73880186 |
59 | Other glycan degradation_Homo sapiens_hsa00511 | 0.73873930 |
60 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.73340770 |
61 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.72106723 |
62 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.71638489 |
63 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.68948489 |
64 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.68077934 |
65 | Prion diseases_Homo sapiens_hsa05020 | 0.67269517 |
66 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.66764614 |
67 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.65363305 |
68 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.64252599 |
69 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.60399325 |
70 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.60041758 |
71 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.58852328 |
72 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.56165037 |
73 | Platelet activation_Homo sapiens_hsa04611 | 0.54597625 |
74 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.53342591 |
75 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.52051856 |
76 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.51958250 |
77 | HTLV-I infection_Homo sapiens_hsa05166 | 0.50622863 |
78 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.50244140 |
79 | * Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.46559172 |
80 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.46222464 |
81 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.40100820 |
82 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.36000190 |
83 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.35959631 |
84 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.35645849 |
85 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.35506810 |
86 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.34775822 |
87 | Focal adhesion_Homo sapiens_hsa04510 | 0.34070219 |
88 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.32023560 |
89 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.31506284 |
90 | Proteasome_Homo sapiens_hsa03050 | 0.30245801 |
91 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.29723803 |
92 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.27916166 |
93 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.27336264 |
94 | Bladder cancer_Homo sapiens_hsa05219 | 0.27233325 |
95 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.24096937 |
96 | Adherens junction_Homo sapiens_hsa04520 | 0.22114467 |
97 | Prostate cancer_Homo sapiens_hsa05215 | 0.21748625 |
98 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.21709133 |
99 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.21467879 |
100 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.21186366 |
101 | Insulin resistance_Homo sapiens_hsa04931 | 0.20952491 |
102 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.20282080 |
103 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.19936401 |
104 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.18687571 |
105 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.17009944 |
106 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.16461703 |
107 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.14864747 |
108 | RNA degradation_Homo sapiens_hsa03018 | 0.13094645 |
109 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.12854859 |
110 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.11704614 |
111 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.11416593 |
112 | Galactose metabolism_Homo sapiens_hsa00052 | 0.11064572 |
113 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.10626608 |
114 | Endocytosis_Homo sapiens_hsa04144 | 0.09533761 |
115 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.09356636 |
116 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.08815563 |
117 | Mineral absorption_Homo sapiens_hsa04978 | 0.07480944 |