RIPK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.54992301
2negative regulation of cell killing (GO:0031342)5.54777966
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.54777966
4positive regulation by symbiont of host defense response (GO:0052509)4.61386003
5modulation by symbiont of host defense response (GO:0052031)4.61386003
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.61386003
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.61386003
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.61386003
9modulation by symbiont of host immune response (GO:0052553)4.61386003
10detection of other organism (GO:0098543)4.39969158
11negative regulation of interleukin-12 production (GO:0032695)4.30847580
12DNA deamination (GO:0045006)4.29338386
13detection of bacterium (GO:0016045)4.28643635
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.23854944
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23854944
16response to peptidoglycan (GO:0032494)4.22704619
17viral transcription (GO:0019083)4.09302735
18macrophage activation involved in immune response (GO:0002281)4.06984021
19DNA strand elongation involved in DNA replication (GO:0006271)4.01170713
20telomere maintenance via semi-conservative replication (GO:0032201)3.96642944
21translational termination (GO:0006415)3.95410545
22Arp2/3 complex-mediated actin nucleation (GO:0034314)3.86419329
23antigen processing and presentation of endogenous antigen (GO:0019883)3.83794049
24DNA strand elongation (GO:0022616)3.81866747
25type I interferon signaling pathway (GO:0060337)3.78633128
26cellular response to type I interferon (GO:0071357)3.78633128
27response to type I interferon (GO:0034340)3.75474504
28neutrophil activation (GO:0042119)3.65834479
29detection of external biotic stimulus (GO:0098581)3.64110535
30DNA unwinding involved in DNA replication (GO:0006268)3.63234147
31maturation of SSU-rRNA (GO:0030490)3.61876925
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61209713
33translational elongation (GO:0006414)3.60017479
34cellular extravasation (GO:0045123)3.59160454
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.58867573
36negative regulation of phagocytosis (GO:0050765)3.58323564
37interferon-gamma-mediated signaling pathway (GO:0060333)3.57208854
38ribosomal small subunit biogenesis (GO:0042274)3.54528693
39regulation of dendritic cell antigen processing and presentation (GO:0002604)3.54381348
40telomere maintenance via recombination (GO:0000722)3.52976737
41regulation of T cell tolerance induction (GO:0002664)3.52250170
42granulocyte activation (GO:0036230)3.52112277
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50991078
44cotranslational protein targeting to membrane (GO:0006613)3.50310328
45protein targeting to ER (GO:0045047)3.49005901
46respiratory burst (GO:0045730)3.48891885
47negative thymic T cell selection (GO:0045060)3.42512732
48negative regulation of T cell mediated immunity (GO:0002710)3.40267716
49positive regulation of gamma-delta T cell activation (GO:0046645)3.39321529
50negative regulation of leukocyte mediated immunity (GO:0002704)3.39119861
51myeloid cell activation involved in immune response (GO:0002275)3.36680133
52regulation of mast cell degranulation (GO:0043304)3.34931751
53regulation of tolerance induction (GO:0002643)3.34884101
54response to interleukin-15 (GO:0070672)3.34486531
55regulation of interferon-beta biosynthetic process (GO:0045357)3.33958915
56regulation of antigen processing and presentation (GO:0002577)3.32994043
57positive regulation of antigen processing and presentation (GO:0002579)3.32863318
58negative T cell selection (GO:0043383)3.31900361
59positive thymic T cell selection (GO:0045059)3.31362585
60protein localization to endoplasmic reticulum (GO:0070972)3.30022658
61detection of molecule of bacterial origin (GO:0032490)3.29248045
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29129570
63DNA replication initiation (GO:0006270)3.26799608
64mitotic recombination (GO:0006312)3.23743104
65response to muramyl dipeptide (GO:0032495)3.23521621
66response to host immune response (GO:0052572)3.22502630
67response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.22502630
68formation of translation preinitiation complex (GO:0001731)3.19893442
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.19669805
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18253749
71detection of biotic stimulus (GO:0009595)3.17567093
72T cell migration (GO:0072678)3.16951367
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15645977
74germinal center formation (GO:0002467)3.15412748
75viral life cycle (GO:0019058)3.15246272
76negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13300146
77translational initiation (GO:0006413)3.12625670
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12298788
79cellular response to interleukin-15 (GO:0071350)3.10505802
80regulation of mast cell activation involved in immune response (GO:0033006)3.05669692
81regulation of myeloid leukocyte mediated immunity (GO:0002886)3.04909838
82antigen processing and presentation via MHC class Ib (GO:0002475)3.04841362
83cellular protein complex disassembly (GO:0043624)3.04233691
84* NIK/NF-kappaB signaling (GO:0038061)3.02210098
85lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00458131
86regulation of leukocyte degranulation (GO:0043300)2.99347759
87regulation of T-helper 2 cell differentiation (GO:0045628)2.98138143
88regulation of alpha-beta T cell proliferation (GO:0046640)2.96765708
89microglial cell activation (GO:0001774)2.95270283
90response to host (GO:0075136)2.95052658
91response to host defenses (GO:0052200)2.95052658
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95052658
93telomere maintenance via telomere lengthening (GO:0010833)2.94484439
94negative regulation of innate immune response (GO:0045824)2.94427991
95leukocyte degranulation (GO:0043299)2.93846153
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93668255
97regulation of mast cell activation (GO:0033003)2.93339557
98regulation of B cell receptor signaling pathway (GO:0050855)2.93278085
99positive regulation of type 2 immune response (GO:0002830)2.92031539
100regulation of regulatory T cell differentiation (GO:0045589)2.91839755
101regulation of natural killer cell mediated immunity (GO:0002715)2.91092905
102regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91092905
103macrophage activation (GO:0042116)2.90992713
104negative regulation of cytokine production involved in immune response (GO:0002719)2.90431663
105dendritic cell chemotaxis (GO:0002407)2.89484617
106T cell selection (GO:0045058)2.88768105
107positive regulation of tolerance induction (GO:0002645)2.87363729
108positive regulation of B cell differentiation (GO:0045579)2.87174982
109response to interferon-beta (GO:0035456)2.86321456
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.85957392
111negative regulation of alpha-beta T cell activation (GO:0046636)2.85762327
112tolerance induction (GO:0002507)2.84005205
113IMP biosynthetic process (GO:0006188)2.83207681
114negative regulation of erythrocyte differentiation (GO:0045647)2.83112933
115positive regulation of mast cell activation (GO:0033005)2.83101121
116negative regulation of T-helper cell differentiation (GO:0045623)2.82014031
117negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82014031
118* regulation of T cell mediated cytotoxicity (GO:0001914)2.79738730
119positive T cell selection (GO:0043368)2.79717446
120definitive hemopoiesis (GO:0060216)2.79367749
121positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77877179
122immunoglobulin mediated immune response (GO:0016064)2.77826772
123actin nucleation (GO:0045010)2.76056787
124ribosomal large subunit biogenesis (GO:0042273)2.76052855
125IMP metabolic process (GO:0046040)2.72343897
126protein localization to kinetochore (GO:0034501)2.72178313
127protein complex disassembly (GO:0043241)2.71210199
128B cell mediated immunity (GO:0019724)2.60556278
129purine-containing compound salvage (GO:0043101)2.60512010
130ribonucleoprotein complex biogenesis (GO:0022613)2.58033243
131regulation of B cell differentiation (GO:0045577)2.56595241
132regulation of gamma-delta T cell differentiation (GO:0045586)2.55245640
133nuclear-transcribed mRNA catabolic process (GO:0000956)2.54857549
134deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.53683440
135macromolecular complex disassembly (GO:0032984)2.53170601
136leukocyte aggregation (GO:0070486)2.52580393
137nucleobase biosynthetic process (GO:0046112)2.50878133
138sequestering of actin monomers (GO:0042989)2.49680669
139mature B cell differentiation involved in immune response (GO:0002313)2.49623915
140regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48887649
141B cell receptor signaling pathway (GO:0050853)2.45976517
142T cell apoptotic process (GO:0070231)2.45721277
143cellular response to interferon-beta (GO:0035458)2.45479804
144mitotic nuclear envelope disassembly (GO:0007077)2.45368716
145mRNA catabolic process (GO:0006402)2.43207977
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.42625927
147protein localization to chromosome, centromeric region (GO:0071459)2.42029417
148regulation of protein heterodimerization activity (GO:0043497)2.41256768
149positive regulation of lamellipodium assembly (GO:0010592)2.39655739
150antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.39598548
151telomere maintenance (GO:0000723)2.39036959
152regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.38918441
153telomere organization (GO:0032200)2.38409218
154pseudouridine synthesis (GO:0001522)2.37780943
155DNA replication checkpoint (GO:0000076)2.36850309
156RNA catabolic process (GO:0006401)2.35829539
157positive regulation of natural killer cell differentiation (GO:0032825)2.35113710
158translation (GO:0006412)2.34879209
159protein targeting to membrane (GO:0006612)2.33387911
160CENP-A containing nucleosome assembly (GO:0034080)2.31898808
161regulation of gamma-delta T cell activation (GO:0046643)2.31497516
162regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.30582780
163mast cell activation (GO:0045576)2.30282755
164response to protozoan (GO:0001562)2.29414391
165rRNA processing (GO:0006364)2.29121504
166neutrophil activation involved in immune response (GO:0002283)2.27566209
167defense response to protozoan (GO:0042832)2.26489259
168myeloid dendritic cell activation (GO:0001773)2.26129523
169platelet dense granule organization (GO:0060155)2.26097779
1703-UTR-mediated mRNA stabilization (GO:0070935)2.25708395
171cellular response to zinc ion (GO:0071294)2.25205776
172regulation of T cell receptor signaling pathway (GO:0050856)2.23845387
173nuclear envelope disassembly (GO:0051081)2.23144504
174membrane disassembly (GO:0030397)2.23144504
175positive regulation of protein import into nucleus, translocation (GO:0033160)2.22084090
176rRNA metabolic process (GO:0016072)2.19650708
177kinetochore organization (GO:0051383)2.19528879
178response to interferon-alpha (GO:0035455)2.19445914
179chromatin remodeling at centromere (GO:0031055)2.18062265
180angiogenesis involved in wound healing (GO:0060055)2.17528571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.88034954
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59532366
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.07067234
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.77439850
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.64234602
6RUNX_20019798_ChIP-Seq_JUKART_Human2.62683475
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.58343131
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.57173004
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49292697
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43985547
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35268148
12MYC_22102868_ChIP-Seq_BL_Human2.31182329
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31060336
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28688636
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26036284
16SPI1_23127762_ChIP-Seq_K562_Human2.25451564
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.22631629
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17517478
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13186068
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.11220075
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.10541479
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09621059
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09615853
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.07878754
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06184982
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04405712
27VDR_21846776_ChIP-Seq_THP-1_Human2.03136480
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03078221
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97032336
30SPI1_23547873_ChIP-Seq_NB4_Human1.94931086
31SCL_19346495_ChIP-Seq_HPC-7_Human1.93923277
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91237672
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91068337
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89567575
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88030622
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87171312
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.86613940
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84542104
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83125395
40XRN2_22483619_ChIP-Seq_HELA_Human1.79496754
41VDR_23849224_ChIP-Seq_CD4+_Human1.77821884
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76814322
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76748502
44VDR_24787735_ChIP-Seq_THP-1_Human1.73169807
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72609067
46FOXP3_21729870_ChIP-Seq_TREG_Human1.70212906
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68046597
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67958089
49MYB_26560356_Chip-Seq_TH2_Human1.67911396
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66506759
51GATA3_27048872_Chip-Seq_THYMUS_Human1.66115334
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64236250
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.62755362
54MAF_26560356_Chip-Seq_TH1_Human1.60302305
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60024711
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.57027989
57CIITA_25753668_ChIP-Seq_RAJI_Human1.54499660
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53137108
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.51065572
60DCP1A_22483619_ChIP-Seq_HELA_Human1.49829803
61KDM2B_26808549_Chip-Seq_DND41_Human1.48582031
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47175160
63MYB_26560356_Chip-Seq_TH1_Human1.46661833
64UTX_26944678_Chip-Seq_JUKART_Human1.45713811
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45306984
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.43373323
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41308601
68VDR_24763502_ChIP-Seq_THP-1_Human1.41049894
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40892830
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40118538
71GABP_19822575_ChIP-Seq_HepG2_Human1.39488085
72ELK1_19687146_ChIP-ChIP_HELA_Human1.39269308
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39041897
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38477884
75LXR_22292898_ChIP-Seq_THP-1_Human1.37927588
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37290834
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.36604718
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36353466
79GATA1_22025678_ChIP-Seq_K562_Human1.34414969
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.33308373
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33283640
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31412479
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31287282
84TTF2_22483619_ChIP-Seq_HELA_Human1.30525512
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28579360
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27463216
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27358842
88GATA3_26560356_Chip-Seq_TH2_Human1.27121422
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.26226224
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26075786
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25404750
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25153470
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25014844
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23632308
95AR_21909140_ChIP-Seq_LNCAP_Human1.21881556
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21716218
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21119185
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.20658347
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20638768
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20436308
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20388822
102BCL6_27268052_Chip-Seq_Bcells_Human1.19768624
103TFEB_21752829_ChIP-Seq_HELA_Human1.18558975
104GATA1_19941826_ChIP-Seq_K562_Human1.17247404
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16953426
106GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16936571
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.16132358
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15527743
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15204184
110PU_27001747_Chip-Seq_BMDM_Mouse1.13851406
111STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11869651
112BCOR_27268052_Chip-Seq_Bcells_Human1.11266216
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11082175
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10553148
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.09548616
116TCF7_22412390_ChIP-Seq_EML_Mouse1.09091500
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07237927
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06829227
119MAF_26560356_Chip-Seq_TH2_Human1.06584162
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06527880
121PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06495247
122IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05749811
123FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05183995
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05086568
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05001149
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03510543
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01950311
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01783359
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01592912
130NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01434783
131STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01176421
132MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00318451
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98891076
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98380781
135NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98257702
136THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98056113
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97916783
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97816392
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97752166
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96944952
141KDM5A_27292631_Chip-Seq_BREAST_Human0.94026788
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93376222
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88693650
144GATA2_19941826_ChIP-Seq_K562_Human0.88049176
145KDM2B_26808549_Chip-Seq_JURKAT_Human0.86639390
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.85616103
147PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83790983
148CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82210640
149STAT1_20625510_ChIP-Seq_HELA_Human0.81563504
150NCOR1_26117541_ChIP-Seq_K562_Human0.80712740
151SA1_27219007_Chip-Seq_ERYTHROID_Human0.75507381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.59513922
2MP0001835_abnormal_antigen_presentation3.12540553
3MP0003693_abnormal_embryo_hatching2.63503490
4MP0003763_abnormal_thymus_physiology2.57414414
5MP0000685_abnormal_immune_system2.52416813
6MP0009785_altered_susceptibility_to2.43676827
7MP0005671_abnormal_response_to2.42966467
8MP0004808_abnormal_hematopoietic_stem2.37735577
9MP0003436_decreased_susceptibility_to2.35037719
10MP0009333_abnormal_splenocyte_physiolog2.23039975
11MP0005397_hematopoietic_system_phenotyp2.20085738
12MP0001545_abnormal_hematopoietic_system2.20085738
13MP0001800_abnormal_humoral_immune2.13794247
14MP0002398_abnormal_bone_marrow2.13142022
15MP0010094_abnormal_chromosome_stability2.12515029
16MP0006054_spinal_hemorrhage2.10436401
17MP0010352_gastrointestinal_tract_polyps2.09571932
18MP0005000_abnormal_immune_tolerance2.09292612
19MP0005025_abnormal_response_to2.08569395
20MP0002452_abnormal_antigen_presenting2.06851667
21MP0000490_abnormal_crypts_of2.03658953
22MP0002420_abnormal_adaptive_immunity2.03079776
23MP0001819_abnormal_immune_cell2.01131776
24MP0003724_increased_susceptibility_to1.99034888
25MP0008007_abnormal_cellular_replicative1.97683880
26MP0003077_abnormal_cell_cycle1.97159330
27MP0004957_abnormal_blastocyst_morpholog1.97158537
28MP0002723_abnormal_immune_serum1.94294042
29MP0008057_abnormal_DNA_replication1.94120800
30MP0002148_abnormal_hypersensitivity_rea1.92279612
31MP0003111_abnormal_nucleus_morphology1.91204157
32MP0003191_abnormal_cellular_cholesterol1.90083927
33MP0002419_abnormal_innate_immunity1.88629809
34MP0002166_altered_tumor_susceptibility1.88548343
35MP0001853_heart_inflammation1.88496003
36MP0002405_respiratory_system_inflammati1.87734309
37MP0005464_abnormal_platelet_physiology1.83647852
38MP0010155_abnormal_intestine_physiology1.83164704
39MP0002722_abnormal_immune_system1.81965328
40MP0000689_abnormal_spleen_morphology1.81669490
41MP0000716_abnormal_immune_system1.79714949
42MP0001790_abnormal_immune_system1.79544716
43MP0005387_immune_system_phenotype1.79544716
44MP0002429_abnormal_blood_cell1.69547162
45MP0000858_altered_metastatic_potential1.65147585
46MP0008438_abnormal_cutaneous_collagen1.61160581
47MP0000465_gastrointestinal_hemorrhage1.60620808
48MP0003183_abnormal_peptide_metabolism1.60018406
49MP0003279_aneurysm1.58833226
50MP0001873_stomach_inflammation1.57769866
51MP0002006_tumorigenesis1.57397170
52MP0000703_abnormal_thymus_morphology1.51227404
53MP0003303_peritoneal_inflammation1.50199030
54MP0008260_abnormal_autophagy1.45351035
55MP0009278_abnormal_bone_marrow1.43955697
56MP0005310_abnormal_salivary_gland1.43758967
57MP0005023_abnormal_wound_healing1.42288173
58MP0003075_altered_response_to1.39749588
59MP0002019_abnormal_tumor_incidence1.38606594
60MP0002998_abnormal_bone_remodeling1.36192150
61MP0008058_abnormal_DNA_repair1.34372089
62MP0003828_pulmonary_edema1.34039618
63MP0001533_abnormal_skeleton_physiology1.33870278
64MP0001845_abnormal_inflammatory_respons1.33689219
65MP0009840_abnormal_foam_cell1.28879741
66MP0004510_myositis1.28163409
67MP0005166_decreased_susceptibility_to1.25217682
68MP0010368_abnormal_lymphatic_system1.23707981
69MP0003866_abnormal_defecation1.22860470
70MP0010307_abnormal_tumor_latency1.22761500
71MP0002933_joint_inflammation1.22714528
72MP0000343_altered_response_to1.17828567
73MP0005451_abnormal_body_composition1.15707966
74MP0004947_skin_inflammation1.14852938
75MP0003300_gastrointestinal_ulcer1.12971899
76MP0005174_abnormal_tail_pigmentation1.12503297
77MP0002277_abnormal_respiratory_mucosa1.12198050
78MP0003566_abnormal_cell_adhesion1.11293552
79MP0003705_abnormal_hypodermis_morpholog1.10037243
80MP0004883_abnormal_blood_vessel1.09919674
81MP0000604_amyloidosis1.09322938
82MP0006082_CNS_inflammation1.08492485
83MP0005075_abnormal_melanosome_morpholog1.04089028
84MP0003448_altered_tumor_morphology1.03987421
85MP0000350_abnormal_cell_proliferation1.00254403
86MP0002138_abnormal_hepatobiliary_system0.99258020
87MP0008004_abnormal_stomach_pH0.98063323
88MP0001879_abnormal_lymphatic_vessel0.97410323
89MP0008469_abnormal_protein_level0.97217477
90MP0003186_abnormal_redox_activity0.97090696
91* MP0000313_abnormal_cell_death0.97046655
92MP0005164_abnormal_response_to0.95942433
93MP0003690_abnormal_glial_cell0.95847483
94MP0003786_premature_aging0.93531853
95MP0002139_abnormal_hepatobiliary_system0.93235263
96MP0002132_abnormal_respiratory_system0.92971401
97MP0001958_emphysema0.91049914
98MP0009379_abnormal_foot_pigmentation0.86329218
99MP0008932_abnormal_embryonic_tissue0.82476424
100MP0003656_abnormal_erythrocyte_physiolo0.81805225
101MP0002095_abnormal_skin_pigmentation0.81319856
102MP0001986_abnormal_taste_sensitivity0.81259102
103MP0001243_abnormal_dermal_layer0.81081901
104MP0000477_abnormal_intestine_morphology0.80182056
105MP0005390_skeleton_phenotype0.79873206
106MP0003045_fibrosis0.79560911
107MP0001730_embryonic_growth_arrest0.78322456
108MP0004381_abnormal_hair_follicle0.76244972
109MP0003943_abnormal_hepatobiliary_system0.74658029
110MP0005058_abnormal_lysosome_morphology0.69552444
111MP0003172_abnormal_lysosome_physiology0.69105991
112MP0009764_decreased_sensitivity_to0.68631089
113MP0002080_prenatal_lethality0.67919620
114MP0009765_abnormal_xenobiotic_induced0.67764425
115MP0003806_abnormal_nucleotide_metabolis0.67741129
116MP0000249_abnormal_blood_vessel0.66651012
117MP0009763_increased_sensitivity_to0.65115331
118MP0008874_decreased_physiological_sensi0.62509366
119MP0004147_increased_porphyrin_level0.62228421
120MP0005275_abnormal_skin_tensile0.62097252
121MP0000015_abnormal_ear_pigmentation0.61956521
122MP0001851_eye_inflammation0.61776631
123MP0005319_abnormal_enzyme/_coenzyme0.61066901
124MP0001915_intracranial_hemorrhage0.60955789
125MP0001663_abnormal_digestive_system0.60828893
126MP0003795_abnormal_bone_structure0.60492232
127MP0002086_abnormal_extraembryonic_tissu0.59797068
128MP0003453_abnormal_keratinocyte_physiol0.59110209
129MP0005381_digestive/alimentary_phenotyp0.58741950
130MP0003091_abnormal_cell_migration0.56344597
131MP0002136_abnormal_kidney_physiology0.53947558
132MP0005360_urolithiasis0.52945232
133MP0000609_abnormal_liver_physiology0.52145765
134MP0005165_increased_susceptibility_to0.50298546
135MP0005167_abnormal_blood-brain_barrier0.49311560
136MP0000920_abnormal_myelination0.49047155
137MP0005365_abnormal_bile_salt0.47161115

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.13101532
2Thrombocytosis (HP:0001894)5.03172087
3Stomatitis (HP:0010280)4.35871545
4Recurrent gram-negative bacterial infections (HP:0005420)4.16958815
5Myositis (HP:0100614)4.00192449
6Aplastic anemia (HP:0001915)3.87419895
7Abnormal number of erythroid precursors (HP:0012131)3.67163212
8Abnormality of cells of the erythroid lineage (HP:0012130)3.64325824
9Gastrointestinal infarctions (HP:0005244)3.63574287
10IgM deficiency (HP:0002850)3.56623589
11Chronic otitis media (HP:0000389)3.51580753
12Encephalitis (HP:0002383)3.51383446
13Increased IgE level (HP:0003212)3.50646065
14Keratoconjunctivitis sicca (HP:0001097)3.47234670
15Petechiae (HP:0000967)3.37969977
16Abnormality of glycolipid metabolism (HP:0010969)3.37034121
17Abnormality of liposaccharide metabolism (HP:0010968)3.37034121
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.37034121
19Recurrent abscess formation (HP:0002722)3.36546763
20Reticulocytopenia (HP:0001896)3.34819918
21Gingivitis (HP:0000230)3.23353105
22Keratoconjunctivitis (HP:0001096)3.21169554
23Pulmonary infiltrates (HP:0002113)3.12865683
24Urticaria (HP:0001025)3.12767080
25Recurrent bronchitis (HP:0002837)3.08735165
26Eczematoid dermatitis (HP:0000976)3.07917560
27Protrusio acetabuli (HP:0003179)2.99528616
28Inflammation of the large intestine (HP:0002037)2.93991881
29Systemic lupus erythematosus (HP:0002725)2.86963424
30Cellulitis (HP:0100658)2.86182346
31Recurrent viral infections (HP:0004429)2.83218947
32Gastrointestinal inflammation (HP:0004386)2.82557615
33Reduced antithrombin III activity (HP:0001976)2.82118565
34Abnormality of T cell physiology (HP:0011840)2.82001627
35Recurrent bacterial skin infections (HP:0005406)2.79119548
36Increased IgM level (HP:0003496)2.77139984
37Colitis (HP:0002583)2.76555692
38Increased cerebral lipofuscin (HP:0011813)2.70208483
39Recurrent fungal infections (HP:0002841)2.64204266
40Abnormality of T cells (HP:0002843)2.63022535
41Abnormality of the nasal mucosa (HP:0000433)2.62689709
42Episodic fever (HP:0001954)2.60467307
4311 pairs of ribs (HP:0000878)2.57722095
44Nasal polyposis (HP:0100582)2.55427565
45Dysostosis multiplex (HP:0000943)2.52830500
46Pustule (HP:0200039)2.51011496
47Orchitis (HP:0100796)2.50352252
48Type I transferrin isoform profile (HP:0003642)2.47504001
49Osteomyelitis (HP:0002754)2.47438990
50Autoimmune hemolytic anemia (HP:0001890)2.46036845
51Vertebral compression fractures (HP:0002953)2.44514195
52Gingival bleeding (HP:0000225)2.43261599
53Peritonitis (HP:0002586)2.42954962
54Nonimmune hydrops fetalis (HP:0001790)2.42879688
55Abnormality of B cell number (HP:0010975)2.41826275
56B lymphocytopenia (HP:0010976)2.41826275
57Lymphoma (HP:0002665)2.39904224
58IgG deficiency (HP:0004315)2.39607856
59Panhypogammaglobulinemia (HP:0003139)2.39424600
60Arterial thrombosis (HP:0004420)2.38317348
61Amyloidosis (HP:0011034)2.38117980
62Pulmonary embolism (HP:0002204)2.37703110
63Pallor (HP:0000980)2.36769844
64Increased serum ferritin (HP:0003281)2.36351985
65Prolonged bleeding time (HP:0003010)2.35949688
66Abnormality of the pleura (HP:0002103)2.31636388
67Loss of speech (HP:0002371)2.31414899
68Meningitis (HP:0001287)2.31171989
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.29145920
70Gangrene (HP:0100758)2.27647434
71Chronic diarrhea (HP:0002028)2.27328954
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.26846086
73Anorexia (HP:0002039)2.26809631
74Poikiloderma (HP:0001029)2.26795916
75Lymphopenia (HP:0001888)2.25709061
76Obstructive lung disease (HP:0006536)2.25587529
77Chronic obstructive pulmonary disease (HP:0006510)2.25587529
78Autoimmune thrombocytopenia (HP:0001973)2.25317378
79Gastrointestinal stroma tumor (HP:0100723)2.23416626
80Malnutrition (HP:0004395)2.21527916
81Epistaxis (HP:0000421)2.20816009
82Abnormality of iron homeostasis (HP:0011031)2.16964100
83Leukocytosis (HP:0001974)2.16306516
84Myelodysplasia (HP:0002863)2.15716422
85Eosinophilia (HP:0001880)2.15139503
86Premature loss of primary teeth (HP:0006323)2.14473604
87Sepsis (HP:0100806)2.13989988
88Hematochezia (HP:0002573)2.13844719
89Recurrent skin infections (HP:0001581)2.13593407
90Abnormal protein glycosylation (HP:0012346)2.13529974
91Abnormal glycosylation (HP:0012345)2.13529974
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13529974
93Abnormal protein N-linked glycosylation (HP:0012347)2.13529974
94Entropion (HP:0000621)2.13294157
95Hepatosplenomegaly (HP:0001433)2.11624437
96Hypochromic anemia (HP:0001931)2.10919056
97Acute myeloid leukemia (HP:0004808)2.09305194
98T lymphocytopenia (HP:0005403)2.09198162
99Recurrent pneumonia (HP:0006532)2.09159404
100IgA deficiency (HP:0002720)2.06695479
101Mediastinal lymphadenopathy (HP:0100721)2.06527054
102Vacuolated lymphocytes (HP:0001922)2.06487736
103Abnormality of the prostate (HP:0008775)2.05920443
104Vasculitis (HP:0002633)2.05742895
105Impaired platelet aggregation (HP:0003540)2.04428033
106Abnormal platelet function (HP:0011869)2.04428033
107Biconcave vertebral bodies (HP:0004586)2.04417126
108Glomerulopathy (HP:0100820)2.04225175
109Amaurosis fugax (HP:0100576)2.02984286
110Severe combined immunodeficiency (HP:0004430)2.02625720
111Joint swelling (HP:0001386)2.02358030
112Abnormality of T cell number (HP:0011839)2.02154315
113Combined immunodeficiency (HP:0005387)2.00722991
114Abnormality of polysaccharide metabolism (HP:0011012)2.00374741
115Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00374741
116Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00374741
117Macrocytic anemia (HP:0001972)2.00301719
118Polyneuropathy (HP:0001271)1.99515816
119Interstitial pulmonary disease (HP:0006530)1.98727624
120Aortic aneurysm (HP:0004942)1.98398225
121Hypergammaglobulinemia (HP:0010702)1.98360146
122Joint stiffness (HP:0001387)1.98253983
123Restrictive lung disease (HP:0002091)1.98027557
124Chronic mucocutaneous candidiasis (HP:0002728)1.97334052
125Recurrent cutaneous fungal infections (HP:0011370)1.97334052
126Skin rash (HP:0000988)1.96718985
127Abnormal platelet volume (HP:0011876)1.96654950
128Acne (HP:0001061)1.96101865
129Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95875375
130Poor head control (HP:0002421)1.95127803
131Oral leukoplakia (HP:0002745)1.93011136
132Chest pain (HP:0100749)1.91436159
133Microretrognathia (HP:0000308)1.91073170
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.90782930
135Degeneration of anterior horn cells (HP:0002398)1.90313661
136Abnormality of the anterior horn cell (HP:0006802)1.90313661
137Agammaglobulinemia (HP:0004432)1.90101116
138Cervical subluxation (HP:0003308)1.88704244
139Pulmonary fibrosis (HP:0002206)1.88596995
140Purpura (HP:0000979)1.88324052
141Spontaneous hematomas (HP:0007420)1.87540127
142Reduced subcutaneous adipose tissue (HP:0003758)1.85594390
143Pancytopenia (HP:0001876)1.85386540
144Skin ulcer (HP:0200042)1.83211766
145Abnormality of the peritoneum (HP:0002585)1.81237807
146Granulocytopenia (HP:0001913)1.80981177
147Emphysema (HP:0002097)1.80764733
148Abnormality of macrophages (HP:0004311)1.80761507
149Colon cancer (HP:0003003)1.80712257
150Hemoptysis (HP:0002105)1.79686637
151Retrobulbar optic neuritis (HP:0100654)1.77067972
152Optic neuritis (HP:0100653)1.77067972
153Beaking of vertebral bodies (HP:0004568)1.76284374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.42746181
2MAP4K13.63275498
3PIM22.94103676
4NME22.82167865
5KDR2.72388595
6TESK22.40729161
7BLK2.25065530
8PRPF4B2.18562692
9TXK2.16758151
10KIT2.16204605
11ERN12.11173054
12WEE12.07339418
13BUB12.03457087
14TEC2.03306265
15JAK32.00925106
16ZAP701.96158913
17RPS6KA41.92755518
18TGFBR11.89519378
19BTK1.88369793
20MAP2K31.79842276
21TBK11.72994364
22CDC71.72349426
23TNK21.70918797
24FLT31.68826758
25TESK11.66668020
26PKN21.63197992
27STK161.58892867
28EEF2K1.58502132
29STK101.52978018
30MAP3K111.50613670
31EIF2AK11.48247056
32FGR1.39684428
33MAP3K131.37637002
34EPHB11.37257456
35TYK21.36535818
36NEK21.36002237
37ACVR1B1.33206395
38MAP3K101.32569238
39IRAK41.32139068
40LRRK21.31927466
41EIF2AK31.30397685
42JAK21.23195670
43RPS6KB21.22685276
44BMPR21.22234623
45SCYL21.21074630
46CSF1R1.19621781
47PASK1.17835459
48TGFBR21.14093282
49ITK1.11629306
50PIM11.11066075
51SYK1.09741891
52GRK71.07100207
53SIK31.05245496
54IKBKE1.04706163
55CLK11.00612949
56CDK70.99722381
57MAP3K10.99358544
58TAOK20.98713300
59BRSK20.98460539
60MAPKAPK30.95067505
61RIPK10.94230295
62CDK80.93551426
63LCK0.92467838
64CDC42BPA0.92357454
65TRIB30.91962595
66IKBKB0.91286853
67MAP3K140.90398264
68GRK60.90174309
69LYN0.89837147
70PAK40.89774391
71MAP3K80.89224374
72ATR0.88909321
73MAP3K30.87255770
74PDK10.85449010
75MARK30.84872506
76CAMKK20.84226897
77MATK0.81056148
78AURKB0.80672315
79FGFR40.80372096
80VRK10.80324945
81IRAK10.78637940
82PRKD20.77848014
83MKNK10.77060340
84MAPK70.75749748
85NEK90.75691774
86MARK20.73073485
87PDPK10.72044014
88PRKCQ0.72018612
89CDK40.71129625
90HCK0.71073345
91NLK0.69814559
92STK40.69216215
93PTK60.67615020
94TAOK30.64565076
95MYLK0.64284255
96PLK10.63042613
97YES10.62898353
98CSK0.61363784
99TIE10.61174652
100HIPK20.60860278
101TRPM70.60497138
102IRAK30.60361653
103FYN0.60058540
104FGFR30.59914377
105IRAK20.59901489
106DYRK30.59302031
107TAOK10.58471974
108LIMK10.58431563
109TSSK60.57997898
110RAF10.57536987
111MST40.56759148
112PRKG20.55023322
113SIK20.53590892
114KSR20.53448403
115ILK0.53417802
116PAK20.53146041
117MAPK120.53097894
118CCNB10.51853463
119MAP2K60.50651562
120MAP3K60.50112156
121SRPK10.50059497
122CDK60.49961815
123RPS6KC10.49610753
124RPS6KL10.49610753
125TLK10.48860220
126SMG10.48574233
127CAMKK10.47586090
128MAP2K20.45946455
129PIK3CG0.44153693
130MAPKAPK20.43811561
131PAK10.42564629
132CDK190.42344245
133JAK10.41576071
134CHUK0.40947080
135MAP3K50.40670937
136BRSK10.40122382
137MAP3K70.40005130
138EPHA30.38613403
139RPS6KA60.38518399
140DYRK1B0.38433378
141TTK0.37360200
142FES0.36611646
143MAPK110.36263838
144MAP3K120.36237211
145ABL10.34879726
146PRKCD0.30701589
147STK110.30149981
148SIK10.29792104
149MOS0.29491862
150MAPK40.28465693
151PTK2B0.28377653
152RET0.28129772

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40410912
2Ribosome_Homo sapiens_hsa030103.35696924
3Mismatch repair_Homo sapiens_hsa034303.25473587
4Staphylococcus aureus infection_Homo sapiens_hsa051502.91107937
5Autoimmune thyroid disease_Homo sapiens_hsa053202.89433520
6Base excision repair_Homo sapiens_hsa034102.76823512
7Primary immunodeficiency_Homo sapiens_hsa053402.42870801
8Proteasome_Homo sapiens_hsa030502.30326414
9Type I diabetes mellitus_Homo sapiens_hsa049402.26161616
10Homologous recombination_Homo sapiens_hsa034402.24014354
11Nucleotide excision repair_Homo sapiens_hsa034202.20443749
12Spliceosome_Homo sapiens_hsa030402.01683677
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92112329
14Cell cycle_Homo sapiens_hsa041101.84032565
15* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76136762
16Pyrimidine metabolism_Homo sapiens_hsa002401.75992035
17Leishmaniasis_Homo sapiens_hsa051401.73992486
18Antigen processing and presentation_Homo sapiens_hsa046121.73434433
19Rheumatoid arthritis_Homo sapiens_hsa053231.61664711
20p53 signaling pathway_Homo sapiens_hsa041151.56362846
21RNA polymerase_Homo sapiens_hsa030201.55963502
22Hematopoietic cell lineage_Homo sapiens_hsa046401.54913929
23Measles_Homo sapiens_hsa051621.54381540
24Shigellosis_Homo sapiens_hsa051311.54130423
25RNA transport_Homo sapiens_hsa030131.52402434
26Non-homologous end-joining_Homo sapiens_hsa034501.51223057
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49587563
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.44907001
29Herpes simplex infection_Homo sapiens_hsa051681.44427084
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.44099457
31Legionellosis_Homo sapiens_hsa051341.41374811
32One carbon pool by folate_Homo sapiens_hsa006701.37111099
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34494678
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33395544
35Phagosome_Homo sapiens_hsa041451.31205013
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26480919
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26410346
38Lysosome_Homo sapiens_hsa041421.22705608
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22043549
40African trypanosomiasis_Homo sapiens_hsa051431.22016783
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17147288
42Other glycan degradation_Homo sapiens_hsa005111.15737826
43RNA degradation_Homo sapiens_hsa030181.15725715
44Fanconi anemia pathway_Homo sapiens_hsa034601.14355951
45B cell receptor signaling pathway_Homo sapiens_hsa046621.14197030
46Apoptosis_Homo sapiens_hsa042101.12665752
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09504170
48Protein export_Homo sapiens_hsa030601.08242468
49Malaria_Homo sapiens_hsa051441.03681043
50Epstein-Barr virus infection_Homo sapiens_hsa051691.03084723
51Pentose phosphate pathway_Homo sapiens_hsa000301.02805351
52Osteoclast differentiation_Homo sapiens_hsa043801.02307587
53Allograft rejection_Homo sapiens_hsa053301.00139234
54Pertussis_Homo sapiens_hsa051330.97983127
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.97371534
56N-Glycan biosynthesis_Homo sapiens_hsa005100.95401803
57Viral myocarditis_Homo sapiens_hsa054160.94301495
58Hepatitis B_Homo sapiens_hsa051610.93826141
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93806644
60Influenza A_Homo sapiens_hsa051640.92191548
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90638737
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89504347
63HTLV-I infection_Homo sapiens_hsa051660.88618506
64Viral carcinogenesis_Homo sapiens_hsa052030.87286193
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86972457
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.86032612
67Toxoplasmosis_Homo sapiens_hsa051450.84595851
68Asthma_Homo sapiens_hsa053100.82900127
69Acute myeloid leukemia_Homo sapiens_hsa052210.82395944
70Sulfur relay system_Homo sapiens_hsa041220.82339982
71T cell receptor signaling pathway_Homo sapiens_hsa046600.81563811
72Salmonella infection_Homo sapiens_hsa051320.80931611
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79895758
74Purine metabolism_Homo sapiens_hsa002300.78973471
75Chronic myeloid leukemia_Homo sapiens_hsa052200.78005242
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77244375
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76643918
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76297580
79Platelet activation_Homo sapiens_hsa046110.75789031
80Galactose metabolism_Homo sapiens_hsa000520.75365108
81Thyroid cancer_Homo sapiens_hsa052160.75241231
82Basal transcription factors_Homo sapiens_hsa030220.74012585
83Small cell lung cancer_Homo sapiens_hsa052220.72670788
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.71568114
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71284450
86Tuberculosis_Homo sapiens_hsa051520.70096850
87* TNF signaling pathway_Homo sapiens_hsa046680.69843369
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68257203
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65757451
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65542085
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62815940
92Caffeine metabolism_Homo sapiens_hsa002320.62274204
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60472570
94Non-small cell lung cancer_Homo sapiens_hsa052230.59991257
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.59353087
96VEGF signaling pathway_Homo sapiens_hsa043700.59083371
97Endocytosis_Homo sapiens_hsa041440.58629705
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.58579851
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58532124
100Prolactin signaling pathway_Homo sapiens_hsa049170.56892242
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53467930
102Amoebiasis_Homo sapiens_hsa051460.52822242
103mRNA surveillance pathway_Homo sapiens_hsa030150.51653084
104Pancreatic cancer_Homo sapiens_hsa052120.51181107
105Graft-versus-host disease_Homo sapiens_hsa053320.51158602
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50172192
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.48521781
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.48270836
109HIF-1 signaling pathway_Homo sapiens_hsa040660.46135204
110Folate biosynthesis_Homo sapiens_hsa007900.43881581
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43512574
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42984920
113Insulin resistance_Homo sapiens_hsa049310.42935560
114Systemic lupus erythematosus_Homo sapiens_hsa053220.42090080
115Bladder cancer_Homo sapiens_hsa052190.41526098
116Renin-angiotensin system_Homo sapiens_hsa046140.40286189
117Glutathione metabolism_Homo sapiens_hsa004800.40155405
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.39818555
119Chemokine signaling pathway_Homo sapiens_hsa040620.39384580
120MicroRNAs in cancer_Homo sapiens_hsa052060.38668964
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38262582
122Notch signaling pathway_Homo sapiens_hsa043300.37278960
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.36445586
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34892500
125Colorectal cancer_Homo sapiens_hsa052100.34716511
126Hepatitis C_Homo sapiens_hsa051600.34410122
127Arachidonic acid metabolism_Homo sapiens_hsa005900.33738806
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32552014
129FoxO signaling pathway_Homo sapiens_hsa040680.29490470
130Renal cell carcinoma_Homo sapiens_hsa052110.29396334
131GnRH signaling pathway_Homo sapiens_hsa049120.29263454
132Choline metabolism in cancer_Homo sapiens_hsa052310.25750219
133Regulation of autophagy_Homo sapiens_hsa041400.25452084
134Collecting duct acid secretion_Homo sapiens_hsa049660.23801206
135Dorso-ventral axis formation_Homo sapiens_hsa043200.21935503
136MAPK signaling pathway_Homo sapiens_hsa040100.21742204
137Mineral absorption_Homo sapiens_hsa049780.21455605
138Inositol phosphate metabolism_Homo sapiens_hsa005620.20978153
139Complement and coagulation cascades_Homo sapiens_hsa046100.20154197
140Glycerolipid metabolism_Homo sapiens_hsa005610.19657247

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