RIPPLY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein similar to a zebrafish protein which acts as a transcriptional repressor in and is required for somite segmentation in zebrafish embryos (PMID: 16326386). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.27586850
2endoderm formation (GO:0001706)8.08248354
3transcription from mitochondrial promoter (GO:0006390)6.61549502
4regulation of mesoderm development (GO:2000380)6.55815582
5proline metabolic process (GO:0006560)6.52056858
6embryonic process involved in female pregnancy (GO:0060136)6.05037108
7aggressive behavior (GO:0002118)5.82117625
8establishment of apical/basal cell polarity (GO:0035089)5.58289121
9regulation of posttranscriptional gene silencing (GO:0060147)5.55107583
10regulation of gene silencing by miRNA (GO:0060964)5.55107583
11regulation of gene silencing by RNA (GO:0060966)5.55107583
12negative regulation of activin receptor signaling pathway (GO:0032926)5.29028152
13regulation of integrin activation (GO:0033623)5.23047322
14replication fork processing (GO:0031297)5.12917398
15primitive streak formation (GO:0090009)5.06586850
16vitamin catabolic process (GO:0009111)5.01513142
17fat-soluble vitamin catabolic process (GO:0042363)5.01513142
18* anterior/posterior axis specification (GO:0009948)4.96406066
19CENP-A containing nucleosome assembly (GO:0034080)4.93586586
20somatic diversification of immune receptors via somatic mutation (GO:0002566)4.85745757
21somatic hypermutation of immunoglobulin genes (GO:0016446)4.85745757
22mitochondrial DNA metabolic process (GO:0032042)4.84857917
23establishment or maintenance of monopolar cell polarity (GO:0061339)4.80189209
24establishment of monopolar cell polarity (GO:0061162)4.80189209
25positive regulation of protein homooligomerization (GO:0032464)4.80016118
26Rap protein signal transduction (GO:0032486)4.75371143
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.66627962
28chromatin remodeling at centromere (GO:0031055)4.65395549
29cell migration involved in gastrulation (GO:0042074)4.64688963
30embryonic placenta development (GO:0001892)4.60813022
31histone H4-K12 acetylation (GO:0043983)4.59849654
32L-serine transport (GO:0015825)4.59184290
33negative regulation of axon extension involved in axon guidance (GO:0048843)4.54606875
34limb bud formation (GO:0060174)4.52657394
35sulfur amino acid catabolic process (GO:0000098)4.51743608
36regulation of protein homooligomerization (GO:0032462)4.50863852
37gastrulation (GO:0007369)4.48850940
38regulation of translational fidelity (GO:0006450)4.48554477
39dorsal/ventral axis specification (GO:0009950)4.37953122
40embryonic foregut morphogenesis (GO:0048617)4.37912061
41* somite rostral/caudal axis specification (GO:0032525)4.35797654
42ventricular cardiac muscle cell development (GO:0055015)4.33895893
43negative regulation of fatty acid biosynthetic process (GO:0045717)4.32849840
44regulation of activin receptor signaling pathway (GO:0032925)4.31592704
45histone exchange (GO:0043486)4.29660499
46sequestering of extracellular ligand from receptor (GO:0035581)4.28497728
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.23247783
48glyoxylate metabolic process (GO:0046487)4.19459195
49positive regulation of gastrulation (GO:2000543)4.17094496
50glutamine family amino acid biosynthetic process (GO:0009084)4.16924371
51female gonad development (GO:0008585)4.13024463
52regulation of hippo signaling (GO:0035330)4.12747522
53branch elongation of an epithelium (GO:0060602)4.11039087
54trophectodermal cell differentiation (GO:0001829)4.04760973
55UDP-N-acetylglucosamine metabolic process (GO:0006047)3.98052134
56uterus development (GO:0060065)3.91320679
57negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.90551787
58pre-miRNA processing (GO:0031054)3.90440588
59oxidative demethylation (GO:0070989)3.89949772
60mitotic G1 DNA damage checkpoint (GO:0031571)3.88562178
61negative regulation of cell fate specification (GO:0009996)3.86504821
62proteasome assembly (GO:0043248)3.86268759
63signal transduction involved in regulation of gene expression (GO:0023019)3.81531015
64formation of translation preinitiation complex (GO:0001731)3.79073045
65serine transport (GO:0032329)3.76460109
66organ formation (GO:0048645)3.76190200
67DNA deamination (GO:0045006)3.67408068
68negative regulation of axon guidance (GO:1902668)3.62058483
69* embryonic axis specification (GO:0000578)3.54748659
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.54344579
71DNA replication-independent nucleosome organization (GO:0034724)3.53536151
72DNA replication-independent nucleosome assembly (GO:0006336)3.53536151
73positive regulation of cardiac muscle cell proliferation (GO:0060045)3.53269486
74DNA strand renaturation (GO:0000733)3.51594170
75anterior/posterior axis specification, embryo (GO:0008595)3.51070528
76regulation of gastrulation (GO:0010470)3.51004642
77positive regulation of cardiac muscle tissue development (GO:0055025)3.50727418
78mitotic G1/S transition checkpoint (GO:0044819)3.49958455
79positive regulation of protein autophosphorylation (GO:0031954)3.47847485
80mitotic G2/M transition checkpoint (GO:0044818)3.47567838
81genitalia morphogenesis (GO:0035112)3.46216705
82mRNA cleavage (GO:0006379)3.45525999
83response to hepatocyte growth factor (GO:0035728)3.44309797
84cellular response to hepatocyte growth factor stimulus (GO:0035729)3.44309797
85nodal signaling pathway (GO:0038092)3.43992792
86regulation of membrane lipid distribution (GO:0097035)3.42581959
87kidney morphogenesis (GO:0060993)3.41433048
88spliceosomal tri-snRNP complex assembly (GO:0000244)3.40878063
89negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.39974287
90mitotic sister chromatid segregation (GO:0000070)3.39196277
91regulation of axon extension involved in axon guidance (GO:0048841)3.36488047
92embryonic retina morphogenesis in camera-type eye (GO:0060059)3.35821650
93mitotic G2 DNA damage checkpoint (GO:0007095)3.33467640
94embryonic camera-type eye development (GO:0031076)3.33451494
95L-ascorbic acid metabolic process (GO:0019852)3.29863439
96G1 DNA damage checkpoint (GO:0044783)3.28656218
97paraxial mesoderm development (GO:0048339)3.25357661
98atrial cardiac muscle cell action potential (GO:0086014)3.25147217
99branched-chain amino acid catabolic process (GO:0009083)3.25021455
100negative regulation of cell cycle arrest (GO:0071157)3.24889361
101mitochondrial RNA metabolic process (GO:0000959)3.23190780
102apoptotic process involved in morphogenesis (GO:0060561)3.21968511
103heterochromatin organization (GO:0070828)3.21237450
104glomerulus development (GO:0032835)3.18001953
105regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.17735776
106apical protein localization (GO:0045176)3.16464785
107* axis specification (GO:0009798)3.15097117
108positive regulation of cardiac muscle tissue growth (GO:0055023)3.14129573
109negative regulation of embryonic development (GO:0045992)3.13991945
110vagina development (GO:0060068)3.12879813
111endocardial cushion development (GO:0003197)3.12091883
112positive regulation of developmental pigmentation (GO:0048087)3.10959006
113glycosphingolipid biosynthetic process (GO:0006688)3.09212900
114regulation of mitotic spindle checkpoint (GO:1903504)3.08781290
115regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08781290
116determination of adult lifespan (GO:0008340)3.08094057
117regulation of cardioblast differentiation (GO:0051890)3.07313086
118axis elongation (GO:0003401)3.06396934
119behavioral response to ethanol (GO:0048149)3.05930197
120positive regulation by host of viral transcription (GO:0043923)3.05487803
121mitochondrial DNA replication (GO:0006264)3.05407821
122positive regulation of protein oligomerization (GO:0032461)3.04843342
123convergent extension (GO:0060026)3.04505647
124sialylation (GO:0097503)3.03841170
125alkaloid metabolic process (GO:0009820)3.03615717
126regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.03216875
127dosage compensation (GO:0007549)3.01025928
128heme transport (GO:0015886)2.99844119
129negative regulation of protein oligomerization (GO:0032460)2.99830870
130protein neddylation (GO:0045116)2.99745350
131regulation of double-strand break repair (GO:2000779)2.99485327
132serine family amino acid catabolic process (GO:0009071)2.97251445
133glycine metabolic process (GO:0006544)2.95300933
134N-glycan processing (GO:0006491)2.94844949
135cellular response to estrogen stimulus (GO:0071391)2.93395312
136embryonic digestive tract morphogenesis (GO:0048557)2.93227272
137histone H4-K5 acetylation (GO:0043981)2.92710193
138histone H4-K8 acetylation (GO:0043982)2.92710193
139formation of primary germ layer (GO:0001704)2.92079262
140base-excision repair (GO:0006284)2.92003870
141viral mRNA export from host cell nucleus (GO:0046784)2.90959482
142regulation of axon guidance (GO:1902667)2.90500126
143establishment of protein localization to mitochondrial membrane (GO:0090151)2.89446580
144folic acid-containing compound biosynthetic process (GO:0009396)2.89048118
145cellular response to BMP stimulus (GO:0071773)2.88772709
146response to BMP (GO:0071772)2.88772709
147* embryonic pattern specification (GO:0009880)2.88205151
148negative regulation of JAK-STAT cascade (GO:0046426)2.86846512
149regulation of protein oligomerization (GO:0032459)2.85280337
150GDP-mannose metabolic process (GO:0019673)2.85242879
151poly(A)+ mRNA export from nucleus (GO:0016973)2.83785683
152telomere maintenance via semi-conservative replication (GO:0032201)2.81077057
153protein localization to kinetochore (GO:0034501)2.80032476
154gastrulation with mouth forming second (GO:0001702)2.79557956
155negative regulation of Ras GTPase activity (GO:0034261)2.79256584
156labyrinthine layer development (GO:0060711)2.79133164
157midgut development (GO:0007494)2.78973985
158negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.78517763
159negative regulation of DNA repair (GO:0045738)2.77589373
160cullin deneddylation (GO:0010388)2.77247803
161regulation of collateral sprouting (GO:0048670)2.76834785
162DNA integration (GO:0015074)2.76799442
163regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.76386017
164intracellular estrogen receptor signaling pathway (GO:0030520)2.76133825
165regulation of sister chromatid cohesion (GO:0007063)2.75769889
166negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75233873
167non-recombinational repair (GO:0000726)2.75135932
168double-strand break repair via nonhomologous end joining (GO:0006303)2.75135932
169notochord development (GO:0030903)2.75103492
170sister chromatid segregation (GO:0000819)2.74829836
171DNA double-strand break processing (GO:0000729)2.74417666
172polarized epithelial cell differentiation (GO:0030859)2.74342375
173regulation of double-strand break repair via homologous recombination (GO:0010569)2.74000339
174outflow tract septum morphogenesis (GO:0003148)2.73355923
175positive regulation of striated muscle tissue development (GO:0045844)2.71883993
176positive regulation of muscle organ development (GO:0048636)2.71883993
177anatomical structure regression (GO:0060033)2.71133917
178DNA duplex unwinding (GO:0032508)2.70417661
179very-low-density lipoprotein particle assembly (GO:0034379)2.69170187
180female genitalia development (GO:0030540)2.68856797
181branched-chain amino acid metabolic process (GO:0009081)2.68659449
182erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.68528153
183L-phenylalanine metabolic process (GO:0006558)2.68528153
184DNA geometric change (GO:0032392)2.67094250
185positive regulation of mitotic sister chromatid separation (GO:1901970)2.66234226
186positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66234226
187positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66234226
188pteridine-containing compound biosynthetic process (GO:0042559)2.65755715
189regulation of cardiac muscle cell proliferation (GO:0060043)2.65496134
190DNA replication-dependent nucleosome organization (GO:0034723)2.63765379
191DNA replication-dependent nucleosome assembly (GO:0006335)2.63765379
192regulation of cell size (GO:0008361)2.60798349
193phospholipid scrambling (GO:0017121)10.4071899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.70022554
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.70022554
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.70022554
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.65133942
5E2F7_22180533_ChIP-Seq_HELA_Human3.45773626
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.31166046
7* SMAD3_21741376_ChIP-Seq_HESCs_Human3.23975152
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.03568074
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.02088560
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.99363354
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.99204187
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.96515830
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.94118648
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88285828
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.84723467
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78876415
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.78164276
18SMAD3_21741376_ChIP-Seq_EPCs_Human2.70262696
19TCF3_18692474_ChIP-Seq_MEFs_Mouse2.57432877
20SMAD4_21741376_ChIP-Seq_HESCs_Human2.57187930
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56436726
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.55883281
23EOMES_21245162_ChIP-Seq_HESCs_Human2.52295833
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.48822923
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.42120596
26STAT3_1855785_ChIP-Seq_MESCs_Mouse2.38103243
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.37442093
28EWS_26573619_Chip-Seq_HEK293_Human2.35547430
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.34528518
30P300_19829295_ChIP-Seq_ESCs_Human2.34418036
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34344310
32POU5F1_16518401_ChIP-PET_MESCs_Mouse2.27895026
33VDR_22108803_ChIP-Seq_LS180_Human2.20087851
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.17995737
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.14284096
36MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11707877
37WT1_19549856_ChIP-ChIP_CCG9911_Human2.11600508
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08840850
39POU5F1_16153702_ChIP-ChIP_HESCs_Human2.06307919
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.00326464
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99822439
42AR_21909140_ChIP-Seq_LNCAP_Human1.98505852
43ZNF274_21170338_ChIP-Seq_K562_Hela1.97803653
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.94996918
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.94216268
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94183489
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92893201
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92818249
49ELK1_19687146_ChIP-ChIP_HELA_Human1.88775289
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.87553609
51* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.81806177
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80249760
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78264437
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78008365
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.77762556
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76637605
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.73785856
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70177777
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.69615798
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69473361
61TAF15_26573619_Chip-Seq_HEK293_Human1.68185437
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66069675
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62595522
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.62106018
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59467497
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56846923
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56379902
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54477510
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54477510
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53328987
71SOX2_18692474_ChIP-Seq_MEFs_Mouse1.52702033
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.52347977
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.51425832
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50945408
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.50886867
76* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.50162407
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49536537
78* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.48736364
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48499203
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47874697
81* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.47429086
82* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46109634
83FUS_26573619_Chip-Seq_HEK293_Human1.44665200
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.44495020
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.44202829
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42873132
87BCAT_22108803_ChIP-Seq_LS180_Human1.42737938
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41724256
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39944990
90NANOG_18692474_ChIP-Seq_MEFs_Mouse1.39059027
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37922458
92LXR_22292898_ChIP-Seq_THP-1_Human1.37886936
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37250275
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35957628
95EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31754501
96ZNF263_19887448_ChIP-Seq_K562_Human1.31061896
97TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.30935519
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30902917
99MYC_22102868_ChIP-Seq_BL_Human1.30456167
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30069892
101GBX2_23144817_ChIP-Seq_PC3_Human1.29499125
102SOX2_19829295_ChIP-Seq_ESCs_Human1.28913448
103NANOG_19829295_ChIP-Seq_ESCs_Human1.28913448
104LXR_22158963_ChIP-Seq_LIVER_Mouse1.28855249
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.28493267
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28221205
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28194806
108NANOG_16518401_ChIP-PET_MESCs_Mouse1.28194722
109* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27326910
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26654088
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26491400
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25854733
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.25846739
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25734571
115VDR_21846776_ChIP-Seq_THP-1_Human1.24774777
116E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24223296
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23788593
118CBP_20019798_ChIP-Seq_JUKART_Human1.22603495
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22603495
120TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21739938
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21546071
122* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20493769
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20374163
124RACK7_27058665_Chip-Seq_MCF-7_Human1.20011985
125IGF1R_20145208_ChIP-Seq_DFB_Human1.19719052
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19432883
127HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18469164
128MYC_18940864_ChIP-ChIP_HL60_Human1.17590013
129EP300_21415370_ChIP-Seq_HL-1_Mouse1.16632202
130* TCF4_22108803_ChIP-Seq_LS180_Human1.15155264
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15045539
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14979012
133SALL1_21062744_ChIP-ChIP_HESCs_Human1.13423377
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13417519
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13046881
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13046881
137HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12559883
138SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12528114
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11721928
140KAP1_27257070_Chip-Seq_ESCs_Mouse1.10723544
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10033721
142MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09730909
143RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07744848
144SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06517863
145TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06045451
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05209369
147CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04946577
148CRX_20693478_ChIP-Seq_RETINA_Mouse1.04855693
149CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04803481
150TET1_21451524_ChIP-Seq_MESCs_Mouse1.04561032
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04373559
152NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03657613
153PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03451885
154STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03109075
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02898796
156RNF2_27304074_Chip-Seq_NSC_Mouse1.02457726
157CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02140771
158FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01367101
159TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00352216
160KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00275025
161TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00194944
162NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99750959
163PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99718847
164AR_25329375_ChIP-Seq_VCAP_Human0.99693692
165YY1_21170310_ChIP-Seq_MESCs_Mouse0.99657101
166STAT3_23295773_ChIP-Seq_U87_Human0.98657325
167RARB_24833708_ChIP-Seq_LIVER_Mouse0.98312213
168TP63_17297297_ChIP-ChIP_HaCaT_Human0.97964980
169CDX2_22108803_ChIP-Seq_LS180_Human0.97456807
170ER_23166858_ChIP-Seq_MCF-7_Human0.95720810
171SMAD4_21799915_ChIP-Seq_A2780_Human0.94985109
172* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94473735
173EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93539007
174PRDM14_20953172_ChIP-Seq_ESCs_Human0.93323639
175ELK3_25401928_ChIP-Seq_HUVEC_Human0.92960279
176CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92948976
177KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91074258
178ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87500324
179PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87274235
180RARA_24833708_ChIP-Seq_LIVER_Mouse0.87144705
181KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86863969
182CDX2_20551321_ChIP-Seq_CACO-2_Human0.86762567
183SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85163130
184KDM5A_27292631_Chip-Seq_BREAST_Human0.82993165
185SPI1_26923725_Chip-Seq_HPCs_Mouse0.82526383
186BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82314446
187ETS1_21867929_ChIP-Seq_TH2_Mouse0.80905147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage6.85061256
2MP0008057_abnormal_DNA_replication4.83887933
3MP0008004_abnormal_stomach_pH4.19341104
4MP0003195_calcinosis3.81554735
5MP0010030_abnormal_orbit_morphology3.08392069
6MP0003806_abnormal_nucleotide_metabolis3.08009787
7MP0003890_abnormal_embryonic-extraembry3.03295087
8MP0005085_abnormal_gallbladder_physiolo2.80472732
9MP0009697_abnormal_copulation2.71004916
10MP0004264_abnormal_extraembryonic_tissu2.67746548
11MP0005365_abnormal_bile_salt2.52428544
12MP0004133_heterotaxia2.52176249
13MP0002653_abnormal_ependyma_morphology2.45972876
14MP0004957_abnormal_blastocyst_morpholog2.37568869
15MP0009278_abnormal_bone_marrow2.32356942
16MP0010352_gastrointestinal_tract_polyps2.30087668
17MP0004233_abnormal_muscle_weight2.22583207
18MP0003705_abnormal_hypodermis_morpholog2.20732152
19MP0003283_abnormal_digestive_organ2.19130484
20MP0010094_abnormal_chromosome_stability2.13884995
21MP0005171_absent_coat_pigmentation2.13473616
22MP0002009_preneoplasia2.09814817
23MP0002249_abnormal_larynx_morphology2.03382452
24MP0002139_abnormal_hepatobiliary_system2.01647044
25MP0003119_abnormal_digestive_system2.01195067
26MP0008438_abnormal_cutaneous_collagen1.99587146
27MP0010368_abnormal_lymphatic_system1.98805700
28MP0005076_abnormal_cell_differentiation1.96339654
29MP0003385_abnormal_body_wall1.93789236
30MP0002102_abnormal_ear_morphology1.91087078
31MP0005360_urolithiasis1.87897492
32MP0002086_abnormal_extraembryonic_tissu1.86761213
33MP0004197_abnormal_fetal_growth/weight/1.86513118
34MP0005499_abnormal_olfactory_system1.85064394
35MP0005394_taste/olfaction_phenotype1.85064394
36MP0009250_abnormal_appendicular_skeleto1.77039547
37MP0001293_anophthalmia1.77007234
38MP0001666_abnormal_nutrient_absorption1.76145397
39MP0005380_embryogenesis_phenotype1.75744824
40MP0001672_abnormal_embryogenesis/_devel1.75744824
41MP0001485_abnormal_pinna_reflex1.72995700
42MP0003453_abnormal_keratinocyte_physiol1.68166497
43* MP0002084_abnormal_developmental_patter1.66196468
44MP0005275_abnormal_skin_tensile1.60848565
45* MP0002085_abnormal_embryonic_tissue1.56096447
46MP0003111_abnormal_nucleus_morphology1.55640847
47MP0002796_impaired_skin_barrier1.53644424
48MP0002736_abnormal_nociception_after1.51482636
49MP0003937_abnormal_limbs/digits/tail_de1.50522707
50MP0001697_abnormal_embryo_size1.49375962
51MP0005266_abnormal_metabolism1.48371076
52MP0003984_embryonic_growth_retardation1.47150457
53MP0002088_abnormal_embryonic_growth/wei1.44656658
54MP0005367_renal/urinary_system_phenotyp1.43015559
55MP0000516_abnormal_urinary_system1.43015559
56MP0005075_abnormal_melanosome_morpholog1.36869410
57MP0003077_abnormal_cell_cycle1.36537763
58MP0005084_abnormal_gallbladder_morpholo1.36316971
59MP0000350_abnormal_cell_proliferation1.34515255
60MP0001730_embryonic_growth_arrest1.34137434
61MP0000462_abnormal_digestive_system1.33389836
62MP0008932_abnormal_embryonic_tissue1.31272975
63MP0002332_abnormal_exercise_endurance1.30906690
64MP0002269_muscular_atrophy1.30675975
65MP0003943_abnormal_hepatobiliary_system1.26971614
66MP0000762_abnormal_tongue_morphology1.25401116
67MP0002111_abnormal_tail_morphology1.24432344
68MP0001286_abnormal_eye_development1.23679868
69MP0009053_abnormal_anal_canal1.23671852
70MP0004215_abnormal_myocardial_fiber1.22997121
71MP0000372_irregular_coat_pigmentation1.20042712
72MP0005023_abnormal_wound_healing1.18868290
73MP0003786_premature_aging1.16746888
74MP0002282_abnormal_trachea_morphology1.16173534
75MP0008875_abnormal_xenobiotic_pharmacok1.15732605
76MP0003136_yellow_coat_color1.14213691
77MP0004272_abnormal_basement_membrane1.12008266
78MP0002932_abnormal_joint_morphology1.10297606
79MP0003315_abnormal_perineum_morphology1.10253357
80MP0001915_intracranial_hemorrhage1.09655483
81MP0002233_abnormal_nose_morphology1.09477107
82MP0006082_CNS_inflammation1.09386375
83MP0003279_aneurysm1.08781398
84MP0002080_prenatal_lethality1.08348474
85MP0002254_reproductive_system_inflammat1.06884380
86MP0000579_abnormal_nail_morphology1.06702330
87MP0003011_delayed_dark_adaptation1.06669383
88MP0002132_abnormal_respiratory_system1.06288509
89MP0003566_abnormal_cell_adhesion1.06268588
90MP0003137_abnormal_impulse_conducting1.04749516
91MP0003567_abnormal_fetal_cardiomyocyte1.03475824
92MP0008872_abnormal_physiological_respon1.03258364
93MP0002277_abnormal_respiratory_mucosa1.02111800
94MP0002938_white_spotting1.01620088
95MP0003693_abnormal_embryo_hatching1.01024414
96MP0005501_abnormal_skin_physiology1.00442640
97MP0000490_abnormal_crypts_of0.98754400
98MP0003718_maternal_effect0.98746682
99MP0003755_abnormal_palate_morphology0.98389050
100MP0003941_abnormal_skin_development0.97409924
101MP0005397_hematopoietic_system_phenotyp0.96009475
102MP0001545_abnormal_hematopoietic_system0.96009475
103MP0008058_abnormal_DNA_repair0.95476296
104MP0002109_abnormal_limb_morphology0.92502826
105MP0000432_abnormal_head_morphology0.90756546
106MP0000609_abnormal_liver_physiology0.89813475
107MP0004019_abnormal_vitamin_homeostasis0.89784106
108MP0000639_abnormal_adrenal_gland0.88380490
109MP0002127_abnormal_cardiovascular_syste0.88273181
110MP0002092_abnormal_eye_morphology0.87664210
111MP0003868_abnormal_feces_composition0.87288892
112MP0003880_abnormal_central_pattern0.87018414
113MP0000163_abnormal_cartilage_morphology0.86966169
114MP0003935_abnormal_craniofacial_develop0.86886437
115MP0002697_abnormal_eye_size0.86525420
116MP0005257_abnormal_intraocular_pressure0.86339736
117MP0002138_abnormal_hepatobiliary_system0.85697695
118MP0009840_abnormal_foam_cell0.85118491
119MP0002060_abnormal_skin_morphology0.85011366
120MP0001986_abnormal_taste_sensitivity0.84714309
121MP0005187_abnormal_penis_morphology0.83716369
122MP0003252_abnormal_bile_duct0.83487943
123MP0002115_abnormal_skeleton_extremities0.83065064
124MP0000371_diluted_coat_color0.82954070
125MP0005508_abnormal_skeleton_morphology0.82829994
126MP0006072_abnormal_retinal_apoptosis0.81479521
127MP0001340_abnormal_eyelid_morphology0.80837289
128MP0006292_abnormal_olfactory_placode0.80811001
129MP0005248_abnormal_Harderian_gland0.80222408
130MP0005319_abnormal_enzyme/_coenzyme0.80078357
131MP0001849_ear_inflammation0.79639204
132MP0000467_abnormal_esophagus_morphology0.79250320
133MP0008775_abnormal_heart_ventricle0.79192199
134MP0005332_abnormal_amino_acid0.79046808
135MP0003936_abnormal_reproductive_system0.78402023
136MP0005551_abnormal_eye_electrophysiolog0.78027231
137MP0009384_cardiac_valve_regurgitation0.77135983
138MP0004185_abnormal_adipocyte_glucose0.76306181
139MP0010307_abnormal_tumor_latency0.75765345
140MP0009115_abnormal_fat_cell0.75364334
141MP0002019_abnormal_tumor_incidence0.75224763
142* MP0002114_abnormal_axial_skeleton0.75114984
143MP0003186_abnormal_redox_activity0.74549289
144MP0008995_early_reproductive_senescence0.74066355
145MP0001764_abnormal_homeostasis0.73935020
146MP0005623_abnormal_meninges_morphology0.73862937
147MP0010329_abnormal_lipoprotein_level0.73324507
148MP0000678_abnormal_parathyroid_gland0.73102626
149MP0000049_abnormal_middle_ear0.72953320
150MP0000470_abnormal_stomach_morphology0.72718388
151MP0001119_abnormal_female_reproductive0.70612493
152MP0000428_abnormal_craniofacial_morphol0.69797308
153MP0001984_abnormal_olfaction0.69761577
154MP0008789_abnormal_olfactory_epithelium0.68422062
155MP0004145_abnormal_muscle_electrophysio0.68023645
156MP0005253_abnormal_eye_physiology0.67733058
157MP0001879_abnormal_lymphatic_vessel0.67598737
158MP0005197_abnormal_uvea_morphology0.64680275
159MP0005330_cardiomyopathy0.62361019
160MP0003942_abnormal_urinary_system0.61392933
161MP0001177_atelectasis0.61148117
162MP0005391_vision/eye_phenotype0.60733069
163MP0002925_abnormal_cardiovascular_devel0.60667486

Predicted human phenotypes

RankGene SetZ-score
1Abnormal umbilical cord blood vessels (HP:0011403)5.94584007
2Single umbilical artery (HP:0001195)5.94584007
3Abnormality of the fetal cardiovascular system (HP:0010948)5.94584007
4Rib fusion (HP:0000902)5.91371453
5Hypochromic microcytic anemia (HP:0004840)5.19235884
6Abnormal pancreas size (HP:0012094)4.57750816
7Hypoplastic pelvis (HP:0008839)4.45892440
8Rectovaginal fistula (HP:0000143)4.43346471
9Rectal fistula (HP:0100590)4.43346471
10Vaginal fistula (HP:0004320)4.12175304
11Intestinal fistula (HP:0100819)4.01293691
12Alopecia of scalp (HP:0002293)3.92071448
13Abnormality of the umbilical cord (HP:0010881)3.91148133
14Short humerus (HP:0005792)3.89383234
15Turricephaly (HP:0000262)3.84742575
16Gonadal dysgenesis (HP:0000133)3.82642497
17Aplasia/hypoplasia of the humerus (HP:0006507)3.80437656
18Concave nail (HP:0001598)3.77544324
19Annular pancreas (HP:0001734)3.66203530
20Double outlet right ventricle (HP:0001719)3.61557301
21Congenital malformation of the right heart (HP:0011723)3.61557301
22Abnormality of the lower motor neuron (HP:0002366)3.60333779
23Ependymoma (HP:0002888)3.49770944
24Tongue fasciculations (HP:0001308)3.47244722
25Septo-optic dysplasia (HP:0100842)3.45282968
26Muscle fibrillation (HP:0010546)3.45232962
27Abnormal hemoglobin (HP:0011902)3.44929369
28Ulnar bowing (HP:0003031)3.29776338
29Cortical dysplasia (HP:0002539)3.24662987
30Gonadotropin excess (HP:0000837)3.18155690
31Abnormality of the astrocytes (HP:0100707)3.12749078
32Astrocytoma (HP:0009592)3.12749078
33Vertebral fusion (HP:0002948)3.12533214
34Selective tooth agenesis (HP:0001592)3.11088194
35Facial hemangioma (HP:0000329)3.08301594
36Anal stenosis (HP:0002025)3.07934787
37Delayed CNS myelination (HP:0002188)3.07224927
38Coronal craniosynostosis (HP:0004440)3.03628190
39Supernumerary spleens (HP:0009799)3.02809199
40Methylmalonic acidemia (HP:0002912)3.00978004
41Vertebral hypoplasia (HP:0008417)3.00155237
42Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.00155237
43Abdominal situs inversus (HP:0003363)2.99919924
44Abnormality of abdominal situs (HP:0011620)2.99919924
45Asplenia (HP:0001746)2.94195551
46Abnormal auditory evoked potentials (HP:0006958)2.91493733
47Abnormal lung lobation (HP:0002101)2.90140567
48Abnormalities of placenta or umbilical cord (HP:0001194)2.89895221
49Absent radius (HP:0003974)2.89451988
50Increased IgM level (HP:0003496)2.84996551
51Popliteal pterygium (HP:0009756)2.84893658
52Intrahepatic cholestasis (HP:0001406)2.83528327
53Pustule (HP:0200039)2.71840637
54Abnormal ventriculo-arterial connection (HP:0011563)2.71146027
55Transposition of the great arteries (HP:0001669)2.71146027
56Abnormal connection of the cardiac segments (HP:0011545)2.71146027
57Aplasia of the musculature (HP:0100854)2.69559528
58Orthostatic hypotension (HP:0001278)2.69530287
59Disproportionate short-trunk short stature (HP:0003521)2.69181264
60Aplasia involving forearm bones (HP:0009822)2.68826501
61Absent forearm bone (HP:0003953)2.68826501
62Abnormality of the labia minora (HP:0012880)2.68705718
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.68239028
64Abnormal biliary tract physiology (HP:0012439)2.64659451
65Bile duct proliferation (HP:0001408)2.64659451
66Amniotic constriction ring (HP:0009775)2.64424794
67Abnormality of placental membranes (HP:0011409)2.64424794
68Increased serum pyruvate (HP:0003542)2.61099602
69Prolonged partial thromboplastin time (HP:0003645)2.60007083
70Hydroxyprolinuria (HP:0003080)2.58810344
71Abnormality of proline metabolism (HP:0010907)2.58810344
72Myelomeningocele (HP:0002475)2.56587476
73Abnormal vertebral ossification (HP:0100569)2.55134616
74Hypobetalipoproteinemia (HP:0003563)2.53826509
75Progressive inability to walk (HP:0002505)2.53702134
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53196170
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52712794
78Intestinal atresia (HP:0011100)2.51442237
79Poikiloderma (HP:0001029)2.51248373
80Preaxial foot polydactyly (HP:0001841)2.49294583
81Bifid tongue (HP:0010297)2.48320808
82Pseudobulbar signs (HP:0002200)2.45953883
83Preauricular pit (HP:0004467)2.43670229
84Periauricular skin pits (HP:0100277)2.43670229
85Neoplasm of the oral cavity (HP:0100649)2.41511784
86Rhabdomyosarcoma (HP:0002859)2.41504471
87Hypochromic anemia (HP:0001931)2.39337171
88Pancreatic islet-cell hyperplasia (HP:0004510)2.38420588
89Neoplasm of striated muscle (HP:0009728)2.37515538
90Secondary amenorrhea (HP:0000869)2.37240618
91Fused cervical vertebrae (HP:0002949)2.37064824
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.35612689
93Squamous cell carcinoma (HP:0002860)2.30577391
94Aplasia/Hypoplasia involving the musculature (HP:0001460)2.29952191
95Short 5th finger (HP:0009237)2.29215072
96Dynein arm defect of respiratory motile cilia (HP:0012255)2.28922935
97Absent/shortened dynein arms (HP:0200106)2.28922935
98Hypotrichosis (HP:0001006)2.28643356
99Abnormality of methionine metabolism (HP:0010901)2.28603198
100Pigmentary retinal degeneration (HP:0001146)2.25708233
101Bilateral microphthalmos (HP:0007633)2.23289000
102Broad alveolar ridges (HP:0000187)2.21251054
103Basal cell carcinoma (HP:0002671)2.21136311
104Glioma (HP:0009733)2.20808550
105Anophthalmia (HP:0000528)2.20022349
106Hemivertebrae (HP:0002937)2.19382669
107Methylmalonic aciduria (HP:0012120)2.17047957
108Short tibia (HP:0005736)2.16592439
109Dysautonomia (HP:0002459)2.16311845
110Abnormality of the vitamin B12 metabolism (HP:0004341)2.11106442
111Premature rupture of membranes (HP:0001788)2.10575574
112Congenital hip dislocation (HP:0001374)2.10235140
113Missing ribs (HP:0000921)2.09426545
114Vertebral clefting (HP:0008428)2.08276822
115Absent thumb (HP:0009777)2.07332045
116Ankyloglossia (HP:0010296)2.06948465
117Abnormality of pyrimidine metabolism (HP:0004353)2.04708797
118Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04707340
119Infantile muscular hypotonia (HP:0008947)2.04634991
120Abnormality of the parathyroid morphology (HP:0011766)2.03244624
121Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.02980152
122Peritonitis (HP:0002586)2.02438783
123Abnormality of glycolysis (HP:0004366)2.02048481
124Abnormality of aromatic amino acid family metabolism (HP:0004338)2.00673892
125Trismus (HP:0000211)2.00282234
126Short hallux (HP:0010109)1.99884082
127Abnormality of glutamine family amino acid metabolism (HP:0010902)1.96225164
128Scrotal hypoplasia (HP:0000046)1.96126951
129Abnormality of the aortic arch (HP:0012303)1.94887267
130EMG: neuropathic changes (HP:0003445)1.94586512
131Hypotelorism (HP:0000601)1.94066678
132Abnormality of vitamin B metabolism (HP:0004340)1.93951306
133Abnormality of the salivary glands (HP:0010286)1.93723326
134Volvulus (HP:0002580)1.93390917
135Patellar aplasia (HP:0006443)1.92959381
136Proximal placement of thumb (HP:0009623)1.92773498
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92653645
138Shawl scrotum (HP:0000049)1.92516917
139Microglossia (HP:0000171)1.91922026
140Deep venous thrombosis (HP:0002625)1.91467686
141Anal atresia (HP:0002023)1.91138560
142Myocardial infarction (HP:0001658)1.90482692
143Soft skin (HP:0000977)1.90284871
144Abnormality of the pubic bones (HP:0003172)1.89737752
145Bulbar palsy (HP:0001283)1.89545235
146Spinal muscular atrophy (HP:0007269)1.89154197
147Male infertility (HP:0003251)1.88757704
148Malnutrition (HP:0004395)1.88655264
149Abnormality of serum amino acid levels (HP:0003112)1.88435641
150Ureteral duplication (HP:0000073)1.88275082
151Patent foramen ovale (HP:0001655)1.87914079
152Adrenal hypoplasia (HP:0000835)1.87206629
153Carpal bone hypoplasia (HP:0001498)1.86396137
154Deviation of the thumb (HP:0009603)1.86382054
155Split hand (HP:0001171)1.84234117
156Enlarged kidneys (HP:0000105)1.83879925
157Generalized amyotrophy (HP:0003700)1.83148189
158Hyperglycinuria (HP:0003108)1.82828877
159Hamartoma (HP:0010566)1.82005839
160Thin ribs (HP:0000883)1.79805247
161Gastrointestinal atresia (HP:0002589)1.79752829
162Delayed gross motor development (HP:0002194)1.79718699
163Aplasia/Hypoplasia of the uvula (HP:0010293)1.78776442
164Meckel diverticulum (HP:0002245)1.78287331
165Embryonal renal neoplasm (HP:0011794)1.77827067
166Spontaneous abortion (HP:0005268)1.77143912
167Hyperammonemia (HP:0001987)1.76476038
168Diaphragmatic weakness (HP:0009113)1.75712515
169Hypolipoproteinemia (HP:0010981)1.75699387
170Nephroblastoma (Wilms tumor) (HP:0002667)1.75407499
171Short chin (HP:0000331)1.75211701
172Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.75121126
173Aplasia/Hypoplasia of the hallux (HP:0008362)1.75024237
174Short middle phalanx of the 5th finger (HP:0004220)1.74797165
175Hypoalphalipoproteinemia (HP:0003233)1.74751759
176Abnormality of the septum pellucidum (HP:0007375)1.73365591
177Medulloblastoma (HP:0002885)1.72566915
178Delayed puberty (HP:0000823)1.71974428
179Metaphyseal cupping (HP:0003021)1.71045363
180Aplasia/Hypoplasia of the patella (HP:0006498)1.70944459
181Alacrima (HP:0000522)1.70726057
182Spastic diplegia (HP:0001264)1.70528394
183Choanal stenosis (HP:0000452)1.69552720
184Abnormality of male internal genitalia (HP:0000022)1.68891702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.39285096
2ICK5.11410095
3PBK4.61435803
4BMPR1B4.16315435
5DDR24.04260153
6MAPK153.72946032
7CDK123.69306922
8TNIK3.59161510
9ERBB33.51951306
10TYRO33.21342424
11MAP3K63.20104669
12TRIM283.19864425
13MATK2.83126597
14SIK32.55328319
15FGR2.39707750
16PLK22.35873385
17MKNK22.32708549
18MAP3K112.30268187
19BMX2.25449996
20PLK42.23352863
21LATS22.21991113
22WNK32.20089481
23MST42.09601683
24CDK72.08724531
25TGFBR12.06262731
26PINK12.04355039
27CSK1.99090151
28PDGFRA1.97275624
29MAP3K101.94946032
30NUAK11.88095665
31EPHA21.81965876
32PRKD21.74693463
33CASK1.69955681
34DYRK1B1.66185314
35LRRK21.65053609
36RPS6KB21.64435678
37CDK61.60511866
38UHMK11.57175797
39DAPK11.56542309
40PIM21.54452112
41GRK61.53995971
42PLK31.50117086
43EIF2AK31.49613904
44PIM11.48480867
45YES11.47475797
46AKT31.46269655
47TTK1.45132655
48PRKD31.43179497
49BCR1.42586685
50NEK11.40309579
51EIF2AK11.39530578
52ERN11.38453811
53ADRBK11.35211712
54EIF2AK21.29624099
55BRSK21.26926061
56MAP3K81.25040655
57CHEK21.24584499
58MKNK11.23282230
59PLK11.19720414
60STK391.19621611
61MTOR1.08483391
62WNK41.04424189
63GSK3A1.01252113
64BCKDK1.01054554
65MAPK111.00384170
66STK38L0.99139190
67PAK40.97668233
68LATS10.97041135
69GRK50.95108896
70VRK10.94850583
71MAP4K20.92512507
72PNCK0.89657390
73MELK0.89061942
74MAPKAPK30.88388924
75STK100.87055739
76AKT20.85996082
77IRAK20.85721121
78ROCK20.83054545
79MAP3K40.82577404
80NEK20.82129932
81RPS6KC10.82058580
82RPS6KL10.82058580
83TRIB30.79780742
84TGFBR20.79191662
85ALK0.78239101
86MAPK130.77664172
87CDC42BPA0.74082523
88BUB10.72797825
89ERBB20.72472051
90AURKA0.72425361
91MAP3K120.72066400
92TRPM70.72017349
93DYRK30.69042104
94ROCK10.68339895
95CDC70.67764336
96RPS6KA60.67600043
97MOS0.67355984
98BRD40.64936631
99CDK20.63335766
100WEE10.63141627
101BRSK10.62696506
102SIK10.62505851
103CHEK10.61555533
104MAP2K10.60773354
105RPS6KA10.60648895
106IRAK10.58204627
107PRKCQ0.58104029
108PRKAA10.56870648
109CDK40.56257047
110PHKG20.56041573
111PHKG10.56041573
112PDK20.55906330
113IGF1R0.55345745
114PTK20.55239853
115FRK0.54665800
116HIPK20.53770920
117FER0.53322320
118PRKCI0.53199644
119TAF10.53078225
120DMPK0.52230192
121MINK10.51853875
122STK30.50781344
123ATR0.50559840
124ADRBK20.49974028
125PRPF4B0.49872602
126TAOK20.48824977
127FLT30.47477079
128MAPK70.46823493
129TIE10.45650203
130AURKB0.44976690
131MET0.44427078
132EPHA40.44304263
133FGFR10.43958099
134MAP2K70.42331164
135ATM0.42253929
136EGFR0.42087452
137MAPK10.41639730
138TESK20.41093461
139STK380.39251285
140KSR10.38744517
141ERBB40.38210165
142GRK10.38127981
143CSNK2A10.36450376
144NLK0.35817437
145CSNK1E0.35633705
146PKN20.35026351
147CDK10.34786657
148MAP3K90.34708442
149MAPK100.34429998
150PTK60.33904958
151CSNK2A20.32840248
152ILK0.32625059
153MAPK140.32523842
154DYRK20.31868733
155TLK10.29912092
156INSR0.29852565
157MAP3K30.29807600
158CSF1R0.28327912
159PRKG20.27873234
160OBSCN0.24389586
161INSRR0.20703775
162PRKCE0.19975861
163SRPK10.15988766
164ZAK0.15069796
165BRAF0.14997158
166VRK20.14839470
167STK40.14818429
168RAF10.14554822
169PRKD10.13601094
170MAP2K40.13553431
171CAMK2A0.11545321
172OXSR10.08922067
173PRKCB0.07528197
174PRKCD0.07477373

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.54760320
2Fatty acid biosynthesis_Homo sapiens_hsa000613.40871699
3Proteasome_Homo sapiens_hsa030502.98705428
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77685762
5Base excision repair_Homo sapiens_hsa034102.71098161
6DNA replication_Homo sapiens_hsa030302.64409827
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.59701567
8Arginine biosynthesis_Homo sapiens_hsa002202.44101521
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.43831691
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31170516
11Sulfur metabolism_Homo sapiens_hsa009202.29111563
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26081579
13Protein export_Homo sapiens_hsa030602.24107620
14One carbon pool by folate_Homo sapiens_hsa006702.21311296
15Biosynthesis of amino acids_Homo sapiens_hsa012302.19168390
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.15963685
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11067519
18Arginine and proline metabolism_Homo sapiens_hsa003301.97845930
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94546714
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93857093
21Nitrogen metabolism_Homo sapiens_hsa009101.85580663
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82235421
23Fructose and mannose metabolism_Homo sapiens_hsa000511.71448005
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69617442
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69098375
26RNA transport_Homo sapiens_hsa030131.65323491
27Fatty acid metabolism_Homo sapiens_hsa012121.51775477
28Nucleotide excision repair_Homo sapiens_hsa034201.51658969
29Folate biosynthesis_Homo sapiens_hsa007901.50122250
30Sulfur relay system_Homo sapiens_hsa041221.50075888
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49861588
32Hippo signaling pathway_Homo sapiens_hsa043901.47875928
33Complement and coagulation cascades_Homo sapiens_hsa046101.47354909
34Basal transcription factors_Homo sapiens_hsa030221.46064388
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44835182
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44430823
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43104526
38Tryptophan metabolism_Homo sapiens_hsa003801.43046589
39mTOR signaling pathway_Homo sapiens_hsa041501.40796319
40Vitamin B6 metabolism_Homo sapiens_hsa007501.36791141
41Lysine degradation_Homo sapiens_hsa003101.36587211
42Spliceosome_Homo sapiens_hsa030401.33602118
43Notch signaling pathway_Homo sapiens_hsa043301.32157564
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.31528461
45mRNA surveillance pathway_Homo sapiens_hsa030151.29169664
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26090132
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25835492
48Hedgehog signaling pathway_Homo sapiens_hsa043401.25807464
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24006986
50Selenocompound metabolism_Homo sapiens_hsa004501.20621650
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16922807
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16675908
53Homologous recombination_Homo sapiens_hsa034401.13338951
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13156472
55Adherens junction_Homo sapiens_hsa045201.10384255
56Basal cell carcinoma_Homo sapiens_hsa052171.09550890
57Fatty acid elongation_Homo sapiens_hsa000621.09487815
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.05392057
59TGF-beta signaling pathway_Homo sapiens_hsa043501.04385456
60Fanconi anemia pathway_Homo sapiens_hsa034601.03971613
61p53 signaling pathway_Homo sapiens_hsa041151.03233280
62Non-homologous end-joining_Homo sapiens_hsa034501.02925723
63Bladder cancer_Homo sapiens_hsa052191.02574696
64Chemical carcinogenesis_Homo sapiens_hsa052041.01855750
65RNA degradation_Homo sapiens_hsa030181.00695561
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.98991623
67Cell cycle_Homo sapiens_hsa041100.97362531
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93758285
69Carbon metabolism_Homo sapiens_hsa012000.90353397
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89539379
71Galactose metabolism_Homo sapiens_hsa000520.84758354
72Fatty acid degradation_Homo sapiens_hsa000710.83573797
73PPAR signaling pathway_Homo sapiens_hsa033200.78068291
74Caffeine metabolism_Homo sapiens_hsa002320.76875672
75Olfactory transduction_Homo sapiens_hsa047400.75676741
76Steroid biosynthesis_Homo sapiens_hsa001000.74494884
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71361587
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71059429
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70932994
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69631806
81N-Glycan biosynthesis_Homo sapiens_hsa005100.68688847
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67753907
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66789245
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65581254
85Glutathione metabolism_Homo sapiens_hsa004800.63925721
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63364021
87Retinol metabolism_Homo sapiens_hsa008300.62881039
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.62733281
89Phenylalanine metabolism_Homo sapiens_hsa003600.62281844
90Linoleic acid metabolism_Homo sapiens_hsa005910.61889161
91Starch and sucrose metabolism_Homo sapiens_hsa005000.61746151
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.61688549
93Pyruvate metabolism_Homo sapiens_hsa006200.60394812
94Phototransduction_Homo sapiens_hsa047440.60248075
95Circadian rhythm_Homo sapiens_hsa047100.59727088
96Propanoate metabolism_Homo sapiens_hsa006400.59411564
97MicroRNAs in cancer_Homo sapiens_hsa052060.59191650
98Metabolic pathways_Homo sapiens_hsa011000.58736019
99Bile secretion_Homo sapiens_hsa049760.58197570
100Histidine metabolism_Homo sapiens_hsa003400.57773920
101beta-Alanine metabolism_Homo sapiens_hsa004100.57396962
102Staphylococcus aureus infection_Homo sapiens_hsa051500.57246806
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.57218451
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55737010
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55335297
106Tight junction_Homo sapiens_hsa045300.54407570
107AMPK signaling pathway_Homo sapiens_hsa041520.52549881
108Fat digestion and absorption_Homo sapiens_hsa049750.51316983
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50350522
110Peroxisome_Homo sapiens_hsa041460.50005490
111Tyrosine metabolism_Homo sapiens_hsa003500.46512274
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46053874
113Wnt signaling pathway_Homo sapiens_hsa043100.45723162
114Collecting duct acid secretion_Homo sapiens_hsa049660.45395572
115Butanoate metabolism_Homo sapiens_hsa006500.44825048
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44435875
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41968605
118Vitamin digestion and absorption_Homo sapiens_hsa049770.40821804
119Thyroid cancer_Homo sapiens_hsa052160.37990428
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36171743
121Amoebiasis_Homo sapiens_hsa051460.35981627
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.34224664
123Oocyte meiosis_Homo sapiens_hsa041140.33967607
124VEGF signaling pathway_Homo sapiens_hsa043700.33769915
125Viral carcinogenesis_Homo sapiens_hsa052030.32348987
126Prion diseases_Homo sapiens_hsa050200.32342776
127Pentose phosphate pathway_Homo sapiens_hsa000300.32268841
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31713062
129Parkinsons disease_Homo sapiens_hsa050120.31651475
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30984895
131Proteoglycans in cancer_Homo sapiens_hsa052050.22436798

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