RIPPLY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.67561810
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.43580613
3vocalization behavior (GO:0071625)5.34259478
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31385625
5neuron cell-cell adhesion (GO:0007158)5.26612718
6protein localization to synapse (GO:0035418)5.25930177
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.17488339
8regulation of synaptic vesicle exocytosis (GO:2000300)5.14806362
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.09036017
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.03319842
11glutamate secretion (GO:0014047)4.99639845
12gamma-aminobutyric acid signaling pathway (GO:0007214)4.97877571
13neuronal action potential propagation (GO:0019227)4.91012756
14regulation of glutamate receptor signaling pathway (GO:1900449)4.85053255
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.80886913
16glutamate receptor signaling pathway (GO:0007215)4.64994939
17presynaptic membrane organization (GO:0097090)4.64196592
18presynaptic membrane assembly (GO:0097105)4.63542386
19neuron-neuron synaptic transmission (GO:0007270)4.58407800
20regulation of synaptic vesicle transport (GO:1902803)4.57402518
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.56466657
22gamma-aminobutyric acid transport (GO:0015812)4.52136661
23synaptic transmission, glutamatergic (GO:0035249)4.46984664
24postsynaptic membrane organization (GO:0001941)4.45411755
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.35952779
26negative regulation of cytosolic calcium ion concentration (GO:0051481)4.33829130
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29536288
28neurotransmitter-gated ion channel clustering (GO:0072578)4.23916755
29energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.23603345
30ATP hydrolysis coupled proton transport (GO:0015991)4.23603345
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21056138
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.15663775
33neuron recognition (GO:0008038)4.14934104
34cellular ketone body metabolic process (GO:0046950)4.09915702
35response to histamine (GO:0034776)4.09005012
36regulation of postsynaptic membrane potential (GO:0060078)4.06524163
37synaptic vesicle endocytosis (GO:0048488)4.04883970
38neurotransmitter secretion (GO:0007269)3.94675865
39ATP synthesis coupled proton transport (GO:0015986)3.94503973
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94503973
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.90921816
42transferrin transport (GO:0033572)3.90906393
43insulin secretion (GO:0030073)3.86399370
44axonal fasciculation (GO:0007413)3.85843339
45dendritic spine morphogenesis (GO:0060997)3.82274198
46response to pheromone (GO:0019236)3.74780908
47alanine transport (GO:0032328)3.74477729
48positive regulation of synapse maturation (GO:0090129)3.74003589
49positive regulation of synapse assembly (GO:0051965)3.69689946
50regulation of glutamate secretion (GO:0014048)3.69504663
51long-term synaptic potentiation (GO:0060291)3.67264183
52cerebellar granule cell differentiation (GO:0021707)3.66401540
53ferric iron transport (GO:0015682)3.64222868
54trivalent inorganic cation transport (GO:0072512)3.64222868
55inositol phosphate catabolic process (GO:0071545)3.63690336
56ketone body metabolic process (GO:1902224)3.60333771
57endocrine pancreas development (GO:0031018)3.60315721
58water-soluble vitamin biosynthetic process (GO:0042364)3.58360377
59positive regulation of neurotransmitter secretion (GO:0001956)3.56746380
60membrane hyperpolarization (GO:0060081)3.55455544
61cochlea development (GO:0090102)3.54815968
62chaperone-mediated protein transport (GO:0072321)3.53669489
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.51514262
64regulation of type B pancreatic cell apoptotic process (GO:2000674)3.50092022
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.49803801
66mechanosensory behavior (GO:0007638)3.49624664
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46218834
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.45751118
69synaptic vesicle maturation (GO:0016188)3.45557028
70positive regulation of membrane potential (GO:0045838)3.43646292
71positive regulation of neurotransmitter transport (GO:0051590)3.42926149
72inositol phosphate dephosphorylation (GO:0046855)3.40731808
73phosphorylated carbohydrate dephosphorylation (GO:0046838)3.40731808
74neurotransmitter transport (GO:0006836)3.38467047
75regulation of neurotransmitter secretion (GO:0046928)3.34854983
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33743230
77membrane depolarization (GO:0051899)3.32730656
78righting reflex (GO:0060013)3.31694844
79regulation of neuronal synaptic plasticity (GO:0048168)3.31236576
80behavioral defense response (GO:0002209)3.30902323
81behavioral fear response (GO:0001662)3.30902323
82positive regulation of insulin secretion (GO:0032024)3.29022208
83regulation of synaptic plasticity (GO:0048167)3.26100914
84female mating behavior (GO:0060180)3.24916059
85regulation of vesicle fusion (GO:0031338)3.21872277
86auditory behavior (GO:0031223)3.21275930
87protein localization to cilium (GO:0061512)3.18811285
88long-term memory (GO:0007616)3.15681188
89locomotory exploration behavior (GO:0035641)3.14500813
90establishment of synaptic vesicle localization (GO:0097480)3.14126968
91synaptic vesicle transport (GO:0048489)3.14126968
92potassium ion homeostasis (GO:0055075)3.12474228
93regulation of neurotransmitter transport (GO:0051588)3.11492806
94exploration behavior (GO:0035640)3.10790657
95fear response (GO:0042596)3.09965374
96positive regulation of amino acid transport (GO:0051957)3.08464223
97striatum development (GO:0021756)3.07473307
98synaptic transmission (GO:0007268)3.05253037
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04268282
100negative regulation of amino acid transport (GO:0051956)3.04238034
101glycerophospholipid catabolic process (GO:0046475)3.03808724
102regulation of neurotransmitter levels (GO:0001505)3.03311483
103innervation (GO:0060384)3.01758883
104phagosome maturation (GO:0090382)3.01684080
105behavioral response to cocaine (GO:0048148)3.01276589
106detection of calcium ion (GO:0005513)3.00899821
107regulation of glucokinase activity (GO:0033131)3.00860684
108regulation of hexokinase activity (GO:1903299)3.00860684
109polyol catabolic process (GO:0046174)2.99651986
110positive regulation of peptide hormone secretion (GO:0090277)2.99535919
111neuromuscular process controlling posture (GO:0050884)2.99493830
112respiratory electron transport chain (GO:0022904)2.98245288
113long term synaptic depression (GO:0060292)2.97530981
114response to dietary excess (GO:0002021)2.95743856
115proline transport (GO:0015824)2.95404738
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95234112
117startle response (GO:0001964)2.95097619
118regulation of calcium ion-dependent exocytosis (GO:0017158)2.95086884
119response to auditory stimulus (GO:0010996)2.94787149
120positive regulation of peptide secretion (GO:0002793)2.93998958
121regulation of synapse maturation (GO:0090128)2.93444584
122regulation of synapse assembly (GO:0051963)2.93046244
123electron transport chain (GO:0022900)2.92916431
124epithelial cell fate commitment (GO:0072148)2.92269083
125transmission of nerve impulse (GO:0019226)2.92120046
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91869408
127positive regulation of synaptic transmission (GO:0050806)2.91359635
128synapse assembly (GO:0007416)2.90311035
129regulation of feeding behavior (GO:0060259)2.90011559
130membrane depolarization during action potential (GO:0086010)2.85045279
131prepulse inhibition (GO:0060134)2.84496582
132regulation of energy homeostasis (GO:2000505)2.83923770
133regulation of neurotransmitter uptake (GO:0051580)2.83276012
134reflex (GO:0060004)2.79971403
135sphingomyelin metabolic process (GO:0006684)2.78989162
136calcium ion import (GO:0070509)2.77135804
137chemosensory behavior (GO:0007635)2.71507185
138positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70130863
139regulation of insulin secretion (GO:0050796)2.69835143
140atrial cardiac muscle cell action potential (GO:0086014)2.68317755
141peptide hormone secretion (GO:0030072)2.67292991
142protein complex biogenesis (GO:0070271)2.65831291
143positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.65643197
144cellular potassium ion homeostasis (GO:0030007)2.64680584
145respiratory chain complex IV assembly (GO:0008535)2.62521789
146signal release (GO:0023061)2.60685532
147negative regulation of hormone biosynthetic process (GO:0032353)2.60625853
148nitric oxide mediated signal transduction (GO:0007263)2.58382893
149cellular potassium ion transport (GO:0071804)2.57343243
150potassium ion transmembrane transport (GO:0071805)2.57343243
151peptide secretion (GO:0002790)2.56772919
152adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.56605008
153regulation of respiratory system process (GO:0044065)2.56004246
154positive regulation of glycolytic process (GO:0045821)2.54911175
155brain morphogenesis (GO:0048854)2.52293604
156regulation of heart rate by cardiac conduction (GO:0086091)2.50327086
157regulation of peptide hormone secretion (GO:0090276)2.49624605
158cytochrome complex assembly (GO:0017004)2.49187189
159potassium ion transport (GO:0006813)2.48335033
160positive regulation of meiosis (GO:0045836)2.46761038
161neuronal action potential (GO:0019228)2.45403532
162regulation of peptide secretion (GO:0002791)2.45361463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78433082
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.10755936
3GBX2_23144817_ChIP-Seq_PC3_Human4.57731954
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.29627194
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19364314
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15360686
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.83218736
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73425827
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.73384499
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70426446
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70426446
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65963139
13TAF15_26573619_Chip-Seq_HEK293_Human2.64823549
14REST_21632747_ChIP-Seq_MESCs_Mouse2.60423103
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55112917
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.54754134
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41209044
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40073310
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35875897
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32483490
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32247087
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.28971140
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20540037
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19041883
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18472498
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.14920684
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.13924148
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.13813332
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10629044
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09630137
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09173604
32* VDR_22108803_ChIP-Seq_LS180_Human2.06885383
33RARB_27405468_Chip-Seq_BRAIN_Mouse2.00938934
34FUS_26573619_Chip-Seq_HEK293_Human1.96605845
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90705502
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86167681
37P300_19829295_ChIP-Seq_ESCs_Human1.85142093
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77432622
39SMAD4_21799915_ChIP-Seq_A2780_Human1.75107148
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74422155
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.74280141
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.69106618
43DROSHA_22980978_ChIP-Seq_HELA_Human1.61084851
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61069141
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59903363
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57447845
47* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54472266
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.52563375
49AR_21572438_ChIP-Seq_LNCaP_Human1.48256519
50RNF2_27304074_Chip-Seq_NSC_Mouse1.47370771
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45940205
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.45516777
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.44892319
54HTT_18923047_ChIP-ChIP_STHdh_Human1.44242529
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44152846
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43459302
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41874214
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.39605749
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.38187663
60AR_25329375_ChIP-Seq_VCAP_Human1.37607650
61ER_23166858_ChIP-Seq_MCF-7_Human1.36829520
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36444329
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35677742
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33494214
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33371589
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32256511
67IGF1R_20145208_ChIP-Seq_DFB_Human1.27084535
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26716711
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25597269
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.25100857
71ZNF274_21170338_ChIP-Seq_K562_Hela1.24919235
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19378256
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18800415
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.17787157
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16589861
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.14724789
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14594050
78TP53_18474530_ChIP-ChIP_U2OS_Human1.13679642
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12801564
80STAT3_23295773_ChIP-Seq_U87_Human1.12522462
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12287544
82RUNX2_22187159_ChIP-Seq_PCA_Human1.11772622
83JUN_21703547_ChIP-Seq_K562_Human1.10871186
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.10693115
85P53_22387025_ChIP-Seq_ESCs_Mouse1.10645956
86TCF4_22108803_ChIP-Seq_LS180_Human1.10378970
87SOX2_19829295_ChIP-Seq_ESCs_Human1.09793648
88NANOG_19829295_ChIP-Seq_ESCs_Human1.09793648
89TP53_22573176_ChIP-Seq_HFKS_Human1.09058574
90* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08876249
91TCF4_23295773_ChIP-Seq_U87_Human1.07976927
92BCAT_22108803_ChIP-Seq_LS180_Human1.06911186
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.06846755
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06198896
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04979686
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.04667053
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.04461959
98TP53_16413492_ChIP-PET_HCT116_Human1.04100809
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.03690285
100STAT3_18555785_Chip-Seq_ESCs_Mouse1.03278163
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02795142
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02462533
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01769351
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.01009227
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.00540301
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00475971
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00391319
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00195191
109EWS_26573619_Chip-Seq_HEK293_Human0.99863342
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99120893
111AR_19668381_ChIP-Seq_PC3_Human0.98863944
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98826853
113EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98033407
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.97821577
115* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97432114
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97074135
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.96987599
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93855034
119CBP_20019798_ChIP-Seq_JUKART_Human0.93855034
120SOX9_26525672_Chip-Seq_HEART_Mouse0.93009598
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91424181
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89503410
123KDM2B_26808549_Chip-Seq_REH_Human0.88941400
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88446983
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88446983
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87060492
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86610159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.13071916
2MP0004859_abnormal_synaptic_plasticity4.94180343
3MP0003635_abnormal_synaptic_transmissio3.88448886
4MP0009745_abnormal_behavioral_response3.50179918
5MP0001968_abnormal_touch/_nociception3.27006449
6MP0009046_muscle_twitch3.25644697
7MP0002064_seizures3.25512862
8MP0002063_abnormal_learning/memory/cond3.21569019
9MP0002736_abnormal_nociception_after3.06007455
10MP0004270_analgesia2.90562716
11MP0002572_abnormal_emotion/affect_behav2.79709087
12MP0002272_abnormal_nervous_system2.77928797
13MP0001501_abnormal_sleep_pattern2.63266101
14MP0002735_abnormal_chemical_nociception2.46032328
15MP0003787_abnormal_imprinting2.41040622
16MP0005645_abnormal_hypothalamus_physiol2.38856942
17MP0006276_abnormal_autonomic_nervous2.37224419
18MP0003122_maternal_imprinting2.35982430
19MP0001440_abnormal_grooming_behavior2.32861082
20MP0002734_abnormal_mechanical_nocicepti2.21139816
21MP0005379_endocrine/exocrine_gland_phen2.19587323
22MP0001529_abnormal_vocalization2.17357936
23MP0002067_abnormal_sensory_capabilities2.13216259
24MP0010234_abnormal_vibrissa_follicle2.12526607
25MP0001486_abnormal_startle_reflex2.09427468
26MP0002876_abnormal_thyroid_physiology1.98173139
27MP0002837_dystrophic_cardiac_calcinosis1.93863312
28MP0002733_abnormal_thermal_nociception1.93827457
29MP0003879_abnormal_hair_cell1.86436045
30MP0001986_abnormal_taste_sensitivity1.85664023
31MP0001970_abnormal_pain_threshold1.85413492
32MP0001944_abnormal_pancreas_morphology1.85098455
33MP0001984_abnormal_olfaction1.84763817
34MP0005646_abnormal_pituitary_gland1.81313622
35MP0002184_abnormal_innervation1.80661911
36MP0005423_abnormal_somatic_nervous1.74282695
37MP0009780_abnormal_chondrocyte_physiolo1.74256091
38MP0000778_abnormal_nervous_system1.72268807
39MP0003195_calcinosis1.71676428
40MP0002693_abnormal_pancreas_physiology1.68341422
41MP0002557_abnormal_social/conspecific_i1.67103238
42MP0005386_behavior/neurological_phenoty1.62245275
43MP0004924_abnormal_behavior1.62245275
44MP0003283_abnormal_digestive_organ1.60802070
45MP0001188_hyperpigmentation1.59566817
46MP0003329_amyloid_beta_deposits1.51621017
47MP0003123_paternal_imprinting1.51379299
48MP0002822_catalepsy1.50782349
49MP0001905_abnormal_dopamine_level1.49836234
50MP0000569_abnormal_digit_pigmentation1.42743415
51MP0004043_abnormal_pH_regulation1.42193735
52MP0001502_abnormal_circadian_rhythm1.35455709
53MP0002066_abnormal_motor_capabilities/c1.31569450
54MP0004811_abnormal_neuron_physiology1.30972112
55MP0008877_abnormal_DNA_methylation1.30533724
56MP0004142_abnormal_muscle_tone1.29461490
57MP0008569_lethality_at_weaning1.29094417
58MP0010386_abnormal_urinary_bladder1.27064834
59MP0005551_abnormal_eye_electrophysiolog1.25338111
60MP0002909_abnormal_adrenal_gland1.24019175
61MP0000955_abnormal_spinal_cord1.23805201
62MP0003121_genomic_imprinting1.22852259
63MP0002882_abnormal_neuron_morphology1.22640635
64MP0002928_abnormal_bile_duct1.22019824
65MP0004145_abnormal_muscle_electrophysio1.21836447
66MP0000751_myopathy1.20714481
67MP0004742_abnormal_vestibular_system1.17882492
68MP0002638_abnormal_pupillary_reflex1.17189524
69MP0004147_increased_porphyrin_level1.15669504
70MP0002078_abnormal_glucose_homeostasis1.15223631
71MP0005253_abnormal_eye_physiology1.13032299
72MP0000631_abnormal_neuroendocrine_gland1.08016144
73MP0002139_abnormal_hepatobiliary_system1.07943398
74MP0005084_abnormal_gallbladder_morpholo1.06186585
75MP0005448_abnormal_energy_balance1.05608351
76MP0010329_abnormal_lipoprotein_level1.00400315
77MP0004215_abnormal_myocardial_fiber1.00283439
78MP0004019_abnormal_vitamin_homeostasis0.99411199
79MP0002152_abnormal_brain_morphology0.98323675
80MP0001756_abnormal_urination0.96156598
81MP0001963_abnormal_hearing_physiology0.95319820
82MP0000639_abnormal_adrenal_gland0.95153374
83MP0005394_taste/olfaction_phenotype0.93723288
84MP0005499_abnormal_olfactory_system0.93723288
85MP0008874_decreased_physiological_sensi0.91473208
86MP0008961_abnormal_basal_metabolism0.90854591
87MP0002254_reproductive_system_inflammat0.90801297
88MP0008872_abnormal_physiological_respon0.89380664
89MP0003633_abnormal_nervous_system0.89327085
90MP0002938_white_spotting0.87537867
91MP0004085_abnormal_heartbeat0.86702187
92MP0000516_abnormal_urinary_system0.86510400
93MP0005367_renal/urinary_system_phenotyp0.86510400
94MP0004858_abnormal_nervous_system0.86220904
95MP0005220_abnormal_exocrine_pancreas0.85496464
96MP0003953_abnormal_hormone_level0.85077981
97MP0002069_abnormal_eating/drinking_beha0.84715253
98MP0003631_nervous_system_phenotype0.84008211
99MP0002752_abnormal_somatic_nervous0.83910127
100MP0005174_abnormal_tail_pigmentation0.83048385
101MP0005332_abnormal_amino_acid0.82726796
102MP0000003_abnormal_adipose_tissue0.82666456
103MP0001765_abnormal_ion_homeostasis0.79708811
104MP0000427_abnormal_hair_cycle0.78293654
105MP0000013_abnormal_adipose_tissue0.78247376
106MP0005248_abnormal_Harderian_gland0.78029220
107MP0004233_abnormal_muscle_weight0.76536859
108MP0004484_altered_response_of0.76028051
109MP0002229_neurodegeneration0.75826996
110MP0001346_abnormal_lacrimal_gland0.74844841
111MP0000026_abnormal_inner_ear0.74139378
112MP0000604_amyloidosis0.72481202
113MP0001727_abnormal_embryo_implantation0.70664935
114MP0004885_abnormal_endolymph0.69996677
115MP0001664_abnormal_digestion0.68632924
116MP0001485_abnormal_pinna_reflex0.68416529
117MP0005535_abnormal_body_temperature0.67628035
118MP0006072_abnormal_retinal_apoptosis0.63579921
119MP0005623_abnormal_meninges_morphology0.61603955
120MP0006292_abnormal_olfactory_placode0.59870775
121MP0005171_absent_coat_pigmentation0.59471413
122MP0004510_myositis0.59313462
123MP0003632_abnormal_nervous_system0.55742818
124MP0003137_abnormal_impulse_conducting0.55363599
125MP0002163_abnormal_gland_morphology0.52886347
126* MP0001943_abnormal_respiration0.52685110
127MP0003646_muscle_fatigue0.51520540
128MP0002082_postnatal_lethality0.49283714
129MP0010770_preweaning_lethality0.49283714
130MP0001348_abnormal_lacrimal_gland0.48695101
131MP0002102_abnormal_ear_morphology0.48323881
132MP0005310_abnormal_salivary_gland0.47384430

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.30274100
2Epileptic encephalopathy (HP:0200134)5.95014266
3Atonic seizures (HP:0010819)5.79544367
4Focal seizures (HP:0007359)5.60808902
5Hyperventilation (HP:0002883)5.03167040
6Absence seizures (HP:0002121)4.86600963
7Febrile seizures (HP:0002373)4.85525068
8Dialeptic seizures (HP:0011146)4.45654395
9Myokymia (HP:0002411)4.26265517
10Ketoacidosis (HP:0001993)4.22885621
11Visual hallucinations (HP:0002367)4.16683256
12Hyperinsulinemic hypoglycemia (HP:0000825)3.90257943
13Acute necrotizing encephalopathy (HP:0006965)3.75892376
14Generalized tonic-clonic seizures (HP:0002069)3.74452535
15Large for gestational age (HP:0001520)3.64282679
16Hypoglycemic seizures (HP:0002173)3.63547517
17Abnormal mitochondria in muscle tissue (HP:0008316)3.51390639
18Hypoglycemic coma (HP:0001325)3.49166332
19Amblyopia (HP:0000646)3.43618380
20Hypothermia (HP:0002045)3.40042867
21Abnormal hair whorl (HP:0010721)3.38632794
22Progressive macrocephaly (HP:0004481)3.38570762
23Mitochondrial inheritance (HP:0001427)3.30273998
24Limb dystonia (HP:0002451)3.29887399
25Broad-based gait (HP:0002136)3.25166428
26Hyperglycemia (HP:0003074)3.23756739
27Progressive cerebellar ataxia (HP:0002073)3.22432514
28Intestinal atresia (HP:0011100)3.13083978
29Gait imbalance (HP:0002141)3.01102540
30Polyphagia (HP:0002591)2.89971000
31Epileptiform EEG discharges (HP:0011182)2.85625493
32Acute encephalopathy (HP:0006846)2.84021574
33Medial flaring of the eyebrow (HP:0010747)2.81984511
34Abnormal eating behavior (HP:0100738)2.79978579
35Congenital primary aphakia (HP:0007707)2.79785173
36Late onset (HP:0003584)2.77588139
37Anxiety (HP:0000739)2.76206050
38Increased CSF lactate (HP:0002490)2.75240881
39Ketosis (HP:0001946)2.73762479
40Gaze-evoked nystagmus (HP:0000640)2.73136842
41Abnormality of glycolysis (HP:0004366)2.68006873
42Increased serum pyruvate (HP:0003542)2.68006873
43Abnormality of the labia minora (HP:0012880)2.67647263
44Excessive salivation (HP:0003781)2.65633514
45Drooling (HP:0002307)2.65633514
46Abnormality of the pancreatic islet cells (HP:0006476)2.64290924
47Abnormality of endocrine pancreas physiology (HP:0012093)2.64290924
48Congenital stationary night blindness (HP:0007642)2.63193869
49Nephrogenic diabetes insipidus (HP:0009806)2.61889946
50Intention tremor (HP:0002080)2.60068329
51Pheochromocytoma (HP:0002666)2.59355974
52EEG with generalized epileptiform discharges (HP:0011198)2.57428530
53Hepatocellular necrosis (HP:0001404)2.56912914
54Inability to walk (HP:0002540)2.56876665
55Muscular hypotonia of the trunk (HP:0008936)2.56604724
56Agitation (HP:0000713)2.56282807
57Poor suck (HP:0002033)2.55688485
58Truncal ataxia (HP:0002078)2.55288113
59Protruding tongue (HP:0010808)2.53576611
60Neuroendocrine neoplasm (HP:0100634)2.51758420
61Progressive inability to walk (HP:0002505)2.51501153
62Hydroureter (HP:0000072)2.48933341
63Poor eye contact (HP:0000817)2.47148740
64Hypoventilation (HP:0002791)2.46073307
65Methylmalonic acidemia (HP:0002912)2.43998540
66Glycosuria (HP:0003076)2.43356301
67Abnormality of urine glucose concentration (HP:0011016)2.43356301
68Failure to thrive in infancy (HP:0001531)2.39704564
69Abnormality of vitamin B metabolism (HP:0004340)2.39593258
70Impaired vibration sensation in the lower limbs (HP:0002166)2.37231359
71Hyperthyroidism (HP:0000836)2.36287518
72Optic disc pallor (HP:0000543)2.33865007
73Type II lissencephaly (HP:0007260)2.33585666
74Hypsarrhythmia (HP:0002521)2.32287699
75Insulin-resistant diabetes mellitus (HP:0000831)2.32167833
76Dysmetria (HP:0001310)2.31938813
77Postural tremor (HP:0002174)2.29980701
78Oligomenorrhea (HP:0000876)2.26307978
79Double outlet right ventricle (HP:0001719)2.26118594
80Congenital malformation of the right heart (HP:0011723)2.26118594
81Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.25978230
82Supranuclear gaze palsy (HP:0000605)2.24205151
83Specific learning disability (HP:0001328)2.23545959
84Hypomagnesemia (HP:0002917)2.23510306
85Depression (HP:0000716)2.23471079
86Abnormality of binocular vision (HP:0011514)2.23009795
87Diplopia (HP:0000651)2.23009795
88Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22450503
89Nephronophthisis (HP:0000090)2.22195410
90Narrow nasal bridge (HP:0000446)2.21793200
91Impaired social interactions (HP:0000735)2.19490694
92Abnormal social behavior (HP:0012433)2.19490694
93Dysdiadochokinesis (HP:0002075)2.19170813
94Enlarged penis (HP:0000040)2.18915917
95Hemiparesis (HP:0001269)2.16497934
96Thickened helices (HP:0000391)2.12529343
97Cerebral inclusion bodies (HP:0100314)2.11453715
98Vaginal atresia (HP:0000148)2.10871889
99Genital tract atresia (HP:0001827)2.10373187
100Status epilepticus (HP:0002133)2.08861696
101Impaired smooth pursuit (HP:0007772)2.08372951
102Pancreatic cysts (HP:0001737)2.08157333
103Pancreatic fibrosis (HP:0100732)2.07150629
104Generalized myoclonic seizures (HP:0002123)2.06549362
105Cholecystitis (HP:0001082)2.06397258
106Abnormal gallbladder physiology (HP:0012438)2.06397258
107Menstrual irregularities (HP:0000858)2.05222330
108Abnormal EKG (HP:0003115)2.04195832
109Symptomatic seizures (HP:0011145)2.03302998
110Psychosis (HP:0000709)2.02970184
111Diminished movement (HP:0002374)2.02437924
112Fetal akinesia sequence (HP:0001989)2.01377015
113Absent/shortened dynein arms (HP:0200106)2.01376559
114Dynein arm defect of respiratory motile cilia (HP:0012255)2.01376559
115Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99641316
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99641316
117Prominent metopic ridge (HP:0005487)1.99461337
118Akinesia (HP:0002304)1.99356287
119Congenital sensorineural hearing impairment (HP:0008527)1.99081065
120Dysmetric saccades (HP:0000641)1.97879004
121Poor coordination (HP:0002370)1.97706066
122Global brain atrophy (HP:0002283)1.97110668
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96602488
124Abnormality of alanine metabolism (HP:0010916)1.96602488
125Hyperalaninemia (HP:0003348)1.96602488
126Syncope (HP:0001279)1.96405777
127Delusions (HP:0000746)1.96181553
128Absent speech (HP:0001344)1.93977169
129Abnormality of vitamin metabolism (HP:0100508)1.93188251
130True hermaphroditism (HP:0010459)1.92783509
131Abnormal drinking behavior (HP:0030082)1.92420592
132Polydipsia (HP:0001959)1.92420592
133Methylmalonic aciduria (HP:0012120)1.90766262
134Ankle clonus (HP:0011448)1.90621150
135Action tremor (HP:0002345)1.90191521
136Bradykinesia (HP:0002067)1.88346966
137Mutism (HP:0002300)1.87674993
138Esotropia (HP:0000565)1.87216804
139Scanning speech (HP:0002168)1.86142585
140Abnormality of the metopic suture (HP:0005556)1.85786875
141Prolonged QT interval (HP:0001657)1.85647263
142Leukodystrophy (HP:0002415)1.83270738
143Aplasia/hypoplasia of the uterus (HP:0008684)1.81739401
144Abnormality of the lower motor neuron (HP:0002366)1.81199299
145Postural instability (HP:0002172)1.80728226
146Incomplete penetrance (HP:0003829)1.80536852
147Spastic gait (HP:0002064)1.80407746
148Hypokinesia (HP:0002375)1.80073185
149Abnormality of salivation (HP:0100755)1.79728611
150Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79031099
151Abnormal pupillary function (HP:0007686)1.78638852
152Hepatic necrosis (HP:0002605)1.76351513
153Furrowed tongue (HP:0000221)1.76187186
154Urinary bladder sphincter dysfunction (HP:0002839)1.76005750
155Emotional lability (HP:0000712)1.74453386
156Abnormality of the renal medulla (HP:0100957)1.73413075
157Termporal pattern (HP:0011008)1.72839072
158Sensory axonal neuropathy (HP:0003390)1.72302669
159Lipid accumulation in hepatocytes (HP:0006561)1.71794686
160Restlessness (HP:0000711)1.71448312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.72131919
2CASK5.08216140
3NTRK34.19026640
4EPHA44.09104996
5MAP3K124.05252780
6FGFR23.54222077
7MAP3K43.53084705
8MAP2K73.27618342
9RIPK43.17398243
10CDK192.70132762
11DAPK22.57639447
12MAP2K42.47142617
13PHKG12.47040074
14PHKG22.47040074
15PLK22.34398599
16MAP3K92.32763482
17PINK12.28499821
18MINK12.10584364
19NME12.09862098
20DAPK12.09307450
21WNK32.00952370
22MARK11.99258825
23PNCK1.99103568
24MAP3K21.90830651
25BMPR21.80474727
26STK38L1.75958541
27GRK11.73356164
28GRK51.59644864
29OXSR11.48605299
30NTRK21.45987609
31CAMKK21.43875408
32CCNB11.43221682
33AKT31.40103885
34MAP3K131.39135860
35ARAF1.38798956
36KSR11.25902096
37FGFR31.24141401
38PAK61.24098095
39PRKCG1.22401826
40BRAF1.22071791
41MAP4K21.20775907
42PTK2B1.18604255
43CDK51.18363090
44CSNK1G11.17337904
45MAP2K61.11697164
46INSRR1.10171396
47CAMK2A1.07168396
48TSSK61.07018422
49PRPF4B1.05319755
50NLK1.04416161
51MST41.01182851
52NTRK10.99680599
53KSR20.99580292
54PASK0.96376809
55GRK70.94647523
56WNK40.91587805
57TNIK0.89479157
58CSNK1G30.84410486
59CAMKK10.83882329
60CDK180.83206971
61FES0.82957519
62CAMK2B0.82936176
63DAPK30.82311646
64FGR0.81825864
65ERBB30.79338273
66BCR0.78710715
67MAPK130.77938321
68CDK150.77882445
69CDK140.77828043
70MYLK0.70292202
71DYRK20.69258466
72ADRBK10.68285189
73TRPM70.68228063
74CDK11A0.67827421
75BRD40.67816430
76PRKCE0.67216577
77SGK4940.66643914
78SGK2230.66643914
79CAMK10.65660241
80LIMK10.63936417
81GRK60.61968563
82SIK20.61788173
83ROCK20.61757557
84STK380.60083943
85WNK10.58524550
86TNK20.58404861
87ADRBK20.58340902
88UHMK10.57896569
89STK240.57743764
90DYRK1A0.57617831
91PRKAA10.56734840
92CSNK1A1L0.56494191
93CDK80.56364354
94ACVR1B0.53768867
95MKNK20.51927026
96BMPR1B0.51529056
97MAP3K70.50344798
98PDK30.50344497
99PDK40.50344497
100STK30.50201045
101MAP3K60.50009865
102PRKACB0.48700379
103PRKG10.48426450
104TAOK10.48023186
105RPS6KA40.47656514
106SGK20.47434554
107FER0.46735735
108SIK30.46444778
109CAMK2D0.45644324
110SGK10.45635470
111RAF10.44424495
112CSNK1G20.44273746
113TYRO30.44082405
114CSNK1A10.43458576
115PRKCI0.42879293
116CAMK2G0.42259754
117LATS20.39501888
118ZAK0.39278078
119CSNK1E0.39218092
120CSNK1D0.39158120
121PDPK10.38685487
122PRKACA0.38656879
123HIPK20.38304822
124CAMK40.37628354
125MAPK120.35940755
126PKN10.34828913
127PRKAA20.34799806
128STK390.33390123
129STK110.31691592
130PRKCZ0.31340262
131PDK10.31122025
132MAP2K10.30646183
133PRKCA0.30560942
134CAMK1G0.29999987
135RPS6KA30.28828007
136PAK30.28585993
137NEK10.28279855
138CDK30.27451556
139MOS0.26579524
140DDR20.26372139
141CDC42BPA0.25985261
142MAP3K10.25762490
143FYN0.24835581
144PRKCB0.24411876

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.72302407
2Nicotine addiction_Homo sapiens_hsa050334.43305540
3Synaptic vesicle cycle_Homo sapiens_hsa047213.71650881
4Collecting duct acid secretion_Homo sapiens_hsa049663.31195118
5Oxidative phosphorylation_Homo sapiens_hsa001903.17484194
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89903443
7Long-term potentiation_Homo sapiens_hsa047202.60592789
8GABAergic synapse_Homo sapiens_hsa047272.56285031
9Morphine addiction_Homo sapiens_hsa050322.55653919
10Butanoate metabolism_Homo sapiens_hsa006502.53773124
11Circadian entrainment_Homo sapiens_hsa047132.50320106
12Glutamatergic synapse_Homo sapiens_hsa047242.40531335
13Amphetamine addiction_Homo sapiens_hsa050312.32552031
14Parkinsons disease_Homo sapiens_hsa050122.30878737
15Olfactory transduction_Homo sapiens_hsa047402.25405856
16Alzheimers disease_Homo sapiens_hsa050102.18060354
17Vibrio cholerae infection_Homo sapiens_hsa051102.05666645
18Salivary secretion_Homo sapiens_hsa049702.02171829
19Dopaminergic synapse_Homo sapiens_hsa047281.96829753
20Taste transduction_Homo sapiens_hsa047421.95872666
21Renin secretion_Homo sapiens_hsa049241.93358653
22Cardiac muscle contraction_Homo sapiens_hsa042601.92976199
23Protein export_Homo sapiens_hsa030601.91949806
24Vitamin B6 metabolism_Homo sapiens_hsa007501.83567033
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76949686
26Serotonergic synapse_Homo sapiens_hsa047261.76464493
27Long-term depression_Homo sapiens_hsa047301.69061711
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68871937
29Insulin secretion_Homo sapiens_hsa049111.64140968
30Oxytocin signaling pathway_Homo sapiens_hsa049211.63471360
31Huntingtons disease_Homo sapiens_hsa050161.61287260
32Calcium signaling pathway_Homo sapiens_hsa040201.58048499
33Gastric acid secretion_Homo sapiens_hsa049711.51738466
34Cholinergic synapse_Homo sapiens_hsa047251.51244306
35Folate biosynthesis_Homo sapiens_hsa007901.46553770
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.45209083
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36447682
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34756296
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30988929
40Sulfur metabolism_Homo sapiens_hsa009201.29918099
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23256912
42Cocaine addiction_Homo sapiens_hsa050301.22249747
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19007246
44GnRH signaling pathway_Homo sapiens_hsa049121.14871464
45Selenocompound metabolism_Homo sapiens_hsa004501.14794248
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14723270
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12229330
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11476265
49Gap junction_Homo sapiens_hsa045401.11166851
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10890318
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10164627
52Sphingolipid metabolism_Homo sapiens_hsa006001.08643995
53Regulation of autophagy_Homo sapiens_hsa041401.06373032
54Phototransduction_Homo sapiens_hsa047441.04644999
55Ether lipid metabolism_Homo sapiens_hsa005651.00158590
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97836939
57Rheumatoid arthritis_Homo sapiens_hsa053230.94794417
58Propanoate metabolism_Homo sapiens_hsa006400.91670674
59cAMP signaling pathway_Homo sapiens_hsa040240.91111028
60Basal transcription factors_Homo sapiens_hsa030220.90184413
61Axon guidance_Homo sapiens_hsa043600.89162103
62Melanogenesis_Homo sapiens_hsa049160.87608195
63Tryptophan metabolism_Homo sapiens_hsa003800.87065867
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86308615
65Estrogen signaling pathway_Homo sapiens_hsa049150.84974361
66Linoleic acid metabolism_Homo sapiens_hsa005910.80592164
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.78740693
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78246327
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77890461
70Mineral absorption_Homo sapiens_hsa049780.76527501
71Peroxisome_Homo sapiens_hsa041460.75866512
72Dilated cardiomyopathy_Homo sapiens_hsa054140.74622074
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73767138
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70554822
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70070611
76Fatty acid elongation_Homo sapiens_hsa000620.66488790
77Nitrogen metabolism_Homo sapiens_hsa009100.63692655
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63136606
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62884713
80African trypanosomiasis_Homo sapiens_hsa051430.62829211
81Glioma_Homo sapiens_hsa052140.62236406
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60529773
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60286777
84Pyruvate metabolism_Homo sapiens_hsa006200.58133389
85MAPK signaling pathway_Homo sapiens_hsa040100.57628754
86Oocyte meiosis_Homo sapiens_hsa041140.57402396
87Pancreatic secretion_Homo sapiens_hsa049720.55885977
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55816903
89ErbB signaling pathway_Homo sapiens_hsa040120.54384330
90ABC transporters_Homo sapiens_hsa020100.54039785
91Fatty acid metabolism_Homo sapiens_hsa012120.53787361
92beta-Alanine metabolism_Homo sapiens_hsa004100.52488082
93Glucagon signaling pathway_Homo sapiens_hsa049220.50111159
94Phagosome_Homo sapiens_hsa041450.50099680
95Thyroid hormone synthesis_Homo sapiens_hsa049180.48790016
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47780295
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46869646
98Type II diabetes mellitus_Homo sapiens_hsa049300.46862685
99Metabolic pathways_Homo sapiens_hsa011000.42233296
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39804934
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39712901
102Alcoholism_Homo sapiens_hsa050340.38863253
103Type I diabetes mellitus_Homo sapiens_hsa049400.38580902
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38268798
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.37414054
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37328423
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37204660
108Choline metabolism in cancer_Homo sapiens_hsa052310.36686048
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36480197
110Retinol metabolism_Homo sapiens_hsa008300.35879950
111Ras signaling pathway_Homo sapiens_hsa040140.35474456
112VEGF signaling pathway_Homo sapiens_hsa043700.34469960
113Circadian rhythm_Homo sapiens_hsa047100.32530108
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.32212192
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29685337
116Inositol phosphate metabolism_Homo sapiens_hsa005620.29676098
117Prion diseases_Homo sapiens_hsa050200.29641209
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28887492
119Rap1 signaling pathway_Homo sapiens_hsa040150.28748878
120Wnt signaling pathway_Homo sapiens_hsa043100.25443755
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24767046
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24620827
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23927389
124Melanoma_Homo sapiens_hsa052180.22938292
125Phenylalanine metabolism_Homo sapiens_hsa003600.22846598
126Dorso-ventral axis formation_Homo sapiens_hsa043200.20475229
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18689209
128Bile secretion_Homo sapiens_hsa049760.15261513
129Ovarian steroidogenesis_Homo sapiens_hsa049130.13111252
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12886768
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.12510815
132Renal cell carcinoma_Homo sapiens_hsa052110.12340812
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.12023063
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11195806
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.10199255

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »