RIT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.58764342
2doxorubicin metabolic process (GO:0044598)9.58764342
3daunorubicin metabolic process (GO:0044597)9.58764342
4aminoglycoside antibiotic metabolic process (GO:0030647)6.01512365
5cytidine deamination (GO:0009972)4.84097809
6cytidine metabolic process (GO:0046087)4.84097809
7cytidine catabolic process (GO:0006216)4.84097809
8negative regulation of interleukin-12 production (GO:0032695)4.83314566
9phenol-containing compound catabolic process (GO:0019336)4.53586685
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.35015989
11regulation of response to osmotic stress (GO:0047484)4.23995023
12positive regulation of mast cell activation (GO:0033005)4.20939891
13phagocytosis, recognition (GO:0006910)4.19305486
14cellular extravasation (GO:0045123)4.14675697
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.09495425
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.09495425
17modulation by symbiont of host immune response (GO:0052553)4.09495425
18positive regulation by symbiont of host defense response (GO:0052509)4.09495425
19modulation by symbiont of host defense response (GO:0052031)4.09495425
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.09495425
21neutrophil activation (GO:0042119)4.03091651
22macrophage activation involved in immune response (GO:0002281)4.01559421
23granulocyte activation (GO:0036230)4.00723304
24microglial cell activation (GO:0001774)3.98281765
25negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.95455615
26calcium-mediated signaling using intracellular calcium source (GO:0035584)3.92690787
27maintenance of protein location in nucleus (GO:0051457)3.89924082
28detection of molecule of bacterial origin (GO:0032490)3.83391655
29regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.80931312
30regulation of mast cell activation (GO:0033003)3.67798429
31quinone metabolic process (GO:1901661)3.65320211
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.59944319
33detection of temperature stimulus (GO:0016048)3.58142916
34macrophage activation (GO:0042116)3.54481917
35neutrophil mediated immunity (GO:0002446)3.54309574
36positive regulation of gamma-delta T cell activation (GO:0046645)3.52133182
37regulation of cilium movement (GO:0003352)3.50244255
38regulation of interferon-beta biosynthetic process (GO:0045357)3.40751107
39positive regulation of mast cell activation involved in immune response (GO:0033008)3.36951179
40positive regulation of mast cell degranulation (GO:0043306)3.36951179
41positive regulation of toll-like receptor signaling pathway (GO:0034123)3.35279160
42negative regulation of interleukin-1 beta production (GO:0032691)3.34915061
43superoxide anion generation (GO:0042554)3.29840390
44neutrophil activation involved in immune response (GO:0002283)3.29804633
45myeloid cell activation involved in immune response (GO:0002275)3.28603372
46positive regulation of macrophage cytokine production (GO:0060907)3.24967751
47response to xenobiotic stimulus (GO:0009410)3.21621991
48response to dietary excess (GO:0002021)3.20510714
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19764444
50leukocyte migration involved in inflammatory response (GO:0002523)3.17572054
51GDP-mannose metabolic process (GO:0019673)3.16425314
52regulation of mast cell degranulation (GO:0043304)3.16167233
53positive regulation of chemokine biosynthetic process (GO:0045080)3.16119747
54negative regulation of interleukin-17 production (GO:0032700)3.14127166
55negative regulation of potassium ion transmembrane transport (GO:1901380)3.12921116
56regulation of B cell receptor signaling pathway (GO:0050855)3.12627810
57pyrimidine ribonucleoside catabolic process (GO:0046133)3.11586179
58regulation of mast cell activation involved in immune response (GO:0033006)3.05655712
59ATP synthesis coupled proton transport (GO:0015986)3.04519284
60energy coupled proton transport, down electrochemical gradient (GO:0015985)3.04519284
61electron transport chain (GO:0022900)3.03452449
62negative regulation of interleukin-1 production (GO:0032692)3.02304350
63somite rostral/caudal axis specification (GO:0032525)3.01524978
64positive regulation of TOR signaling (GO:0032008)3.00033602
65regulation of platelet activation (GO:0010543)2.97848923
66coenzyme catabolic process (GO:0009109)2.97236096
67positive regulation of cAMP-mediated signaling (GO:0043950)2.97130214
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95175443
69lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95046111
70respiratory electron transport chain (GO:0022904)2.94722508
71eosinophil chemotaxis (GO:0048245)2.94443124
72muscle organ morphogenesis (GO:0048644)2.91906171
73positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.91384141
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90611189
75negative regulation of cell killing (GO:0031342)2.90611189
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90553154
77regulation of vitamin D biosynthetic process (GO:0060556)2.88951789
78myeloid leukocyte mediated immunity (GO:0002444)2.87798923
79T-helper 1 type immune response (GO:0042088)2.86553396
80phagocytosis, engulfment (GO:0006911)2.84781516
81regulation of MHC class II biosynthetic process (GO:0045346)2.84711975
82positive regulation of cellular amide metabolic process (GO:0034250)2.83378559
83regulation of interferon-alpha production (GO:0032647)2.79174912
84detection of other organism (GO:0098543)2.78638854
85response to host immune response (GO:0052572)2.78549987
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78549987
87oligosaccharide catabolic process (GO:0009313)2.78367463
88detection of external biotic stimulus (GO:0098581)2.77807522
89cofactor catabolic process (GO:0051187)2.77738521
90negative regulation of systemic arterial blood pressure (GO:0003085)2.76644888
91arachidonic acid secretion (GO:0050482)2.75212445
92icosanoid secretion (GO:0032309)2.75212445
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.74118821
94neutrophil chemotaxis (GO:0030593)2.74068844
95negative regulation of mast cell activation (GO:0033004)2.72937186
96negative regulation of cytokine production involved in immune response (GO:0002719)2.72692454
97negative regulation of epidermis development (GO:0045683)2.72305652
98cellular response to ATP (GO:0071318)2.71781030
99regulation of mononuclear cell migration (GO:0071675)2.71033328
100regulation of interleukin-12 production (GO:0032655)2.71020633
101positive regulation of monocyte chemotaxis (GO:0090026)2.70777994
102eosinophil migration (GO:0072677)2.70569091
103positive regulation of NF-kappaB import into nucleus (GO:0042346)2.69181560
104cullin deneddylation (GO:0010388)2.69098568
105nucleoside transmembrane transport (GO:1901642)2.68850759
106positive regulation of interleukin-6 production (GO:0032755)2.68375595
107germinal center formation (GO:0002467)2.68346980
108cellular response to arsenic-containing substance (GO:0071243)2.68328458
109negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.67995279
110regulation of MHC class I biosynthetic process (GO:0045343)2.67806555
111hydrogen peroxide biosynthetic process (GO:0050665)2.67311113
112neutrophil migration (GO:1990266)2.67197152
113phagosome maturation (GO:0090382)2.66224586
114tachykinin receptor signaling pathway (GO:0007217)2.66069291
115positive regulation of odontogenesis (GO:0042482)2.65385679
116detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.64716729
117detection of temperature stimulus involved in sensory perception (GO:0050961)2.64716729
118proline transport (GO:0015824)2.64578451
119endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.64337905
120detection of biotic stimulus (GO:0009595)2.63618552
121regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63497029
122regulation of interleukin-8 biosynthetic process (GO:0045414)2.63460506
123cellular response to nicotine (GO:0071316)2.63319830
124interferon-gamma secretion (GO:0072643)2.62696543
125myeloid leukocyte activation (GO:0002274)2.62343572
126positive regulation of interferon-alpha production (GO:0032727)2.61601417
127regulation of T-helper 1 cell differentiation (GO:0045625)2.60770618
128positive regulation of interferon-beta production (GO:0032728)2.60563544
129leukocyte degranulation (GO:0043299)2.60434469
130positive regulation of interleukin-1 beta secretion (GO:0050718)2.59245975
131negative regulation of T-helper cell differentiation (GO:0045623)2.59150566
132negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59150566
133negative regulation of lipid storage (GO:0010888)2.58977035
134regulation of interleukin-17 production (GO:0032660)2.58323055
135negative regulation of interleukin-6 production (GO:0032715)2.57954021
136activated T cell proliferation (GO:0050798)2.57196471
137respiratory burst (GO:0045730)2.56882987
138regulation of interleukin-6 biosynthetic process (GO:0045408)2.56827883
139defense response to protozoan (GO:0042832)2.56379948
140cellular response to thyroid hormone stimulus (GO:0097067)2.56282632
141response to water (GO:0009415)2.56176952
142response to protozoan (GO:0001562)2.55345380
143glycoside metabolic process (GO:0016137)2.52055778
144negative regulation of T cell mediated immunity (GO:0002710)2.51551209
145positive regulation of leukocyte degranulation (GO:0043302)2.49602542
146cytokine secretion (GO:0050663)2.49102599
147regulation of interleukin-6 production (GO:0032675)2.49024203
148regulation of apoptotic process involved in morphogenesis (GO:1902337)2.48821213
149negative regulation of alpha-beta T cell activation (GO:0046636)2.48517274
150nerve growth factor signaling pathway (GO:0038180)2.47830860
151Rap protein signal transduction (GO:0032486)2.47766279
152cyclooxygenase pathway (GO:0019371)2.47169379
153positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.47001583
154negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.46731241
155sequestering of actin monomers (GO:0042989)2.46728171
156regulation of regulatory T cell differentiation (GO:0045589)2.46515479
157positive regulation of heat generation (GO:0031652)2.46040185
158regulation of microtubule-based movement (GO:0060632)2.45581323
159positive regulation of tissue remodeling (GO:0034105)2.43947091
160monocyte chemotaxis (GO:0002548)2.43776730
161rRNA transcription (GO:0009303)2.42640345
162membrane raft organization (GO:0031579)2.41940088
163protein deneddylation (GO:0000338)2.41699069
164melanosome transport (GO:0032402)2.40215228
165establishment of melanosome localization (GO:0032401)2.37851675
166cofactor transport (GO:0051181)2.37622705
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37512785
168response to peptidoglycan (GO:0032494)2.35488407
169regulation of monocyte chemotaxis (GO:0090025)2.34106016
170energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.33375338
171ATP hydrolysis coupled proton transport (GO:0015991)2.33375338
172response to acidic pH (GO:0010447)2.30841557
173regulation of Golgi to plasma membrane protein transport (GO:0042996)2.30286040
174immunoglobulin mediated immune response (GO:0016064)2.29490721
175regulation of chemokine biosynthetic process (GO:0045073)2.28938320
176vasodilation (GO:0042311)2.28225386
177reactive oxygen species biosynthetic process (GO:1903409)2.28091760
178regulation of macrophage cytokine production (GO:0010935)2.27433952
179pigment granule transport (GO:0051904)2.26243607
180establishment of pigment granule localization (GO:0051905)2.24622562
181interferon-gamma production (GO:0032609)2.24484060
182mitochondrial respiratory chain complex I assembly (GO:0032981)2.24211875
183NADH dehydrogenase complex assembly (GO:0010257)2.24211875
184mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.24211875
185phosphatidylinositol acyl-chain remodeling (GO:0036149)2.24032855
186creatine metabolic process (GO:0006600)2.22659314
187positive regulation of interleukin-17 production (GO:0032740)2.20409934
188negative regulation of B cell mediated immunity (GO:0002713)2.18555777
189negative regulation of immunoglobulin mediated immune response (GO:0002890)2.18555777
190regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.17224040
191positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.16995632
192protein complex biogenesis (GO:0070271)2.16281285
193positive regulation of digestive system process (GO:0060456)2.14168532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.68266096
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.91996952
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.91996952
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.91996952
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.58889564
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73820312
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68464171
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.68320471
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39414991
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30872904
11GBX2_23144817_ChIP-Seq_PC3_Human2.24691724
12VDR_24787735_ChIP-Seq_THP-1_Human2.13173087
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.10870709
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07366197
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07340576
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.03954963
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03284225
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91579264
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85735375
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84724711
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81849354
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.81214024
23EZH2_22144423_ChIP-Seq_EOC_Human1.77923484
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.76088474
25RUNX_20019798_ChIP-Seq_JUKART_Human1.71990019
26ZNF274_21170338_ChIP-Seq_K562_Hela1.70487051
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70322967
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67019080
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62796715
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62010608
31SCL_19346495_ChIP-Seq_HPC-7_Human1.61669052
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58325004
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.57845155
34P300_19829295_ChIP-Seq_ESCs_Human1.56781332
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53490167
36* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48950092
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48753606
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48097535
39TAF15_26573619_Chip-Seq_HEK293_Human1.47967068
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42721061
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42366856
42GATA1_22025678_ChIP-Seq_K562_Human1.41640684
43ER_23166858_ChIP-Seq_MCF-7_Human1.39702419
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39619592
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39578650
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39045191
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.38916684
48EWS_26573619_Chip-Seq_HEK293_Human1.38655745
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.36435809
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.35350837
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34578970
52* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33165073
53EOMES_21245162_ChIP-Seq_HESCs_Human1.32491721
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29774691
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29073479
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29002102
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28645260
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28580446
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28220015
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26530569
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25521025
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24696691
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.22903131
64GATA3_26560356_Chip-Seq_TH2_Human1.22525986
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21495659
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21380003
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21173655
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20075865
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19869909
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19743594
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18846950
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.17746302
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17253027
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.16238234
75TP53_16413492_ChIP-PET_HCT116_Human1.16033295
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15622557
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14839023
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14716439
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14716439
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.13952239
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.13464268
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12628806
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.12405975
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12188800
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11036226
86CSB_26484114_Chip-Seq_FIBROBLAST_Human1.10768856
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.10208419
88STAT3_23295773_ChIP-Seq_U87_Human1.10122351
89AR_25329375_ChIP-Seq_VCAP_Human1.09676323
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09265422
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09238947
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.09118640
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08388622
94NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08322557
95* SMAD4_21799915_ChIP-Seq_A2780_Human1.08044593
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08031535
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07369254
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07057735
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.06313322
100P53_22387025_ChIP-Seq_ESCs_Mouse1.05702154
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05558566
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05440599
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05381511
104SMRT_27268052_Chip-Seq_Bcells_Human1.04986994
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04236117
106IGF1R_20145208_ChIP-Seq_DFB_Human1.03881652
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.03823903
108PU_27001747_Chip-Seq_BMDM_Mouse1.03629192
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03606797
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02790624
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02695813
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01556424
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.01336322
114BCAT_22108803_ChIP-Seq_LS180_Human1.01296081
115P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00636167
116* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99688782
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99301657
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99301657
119CJUN_26792858_Chip-Seq_BT549_Human0.99257112
120FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99012517
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.98648089
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.98350571
123CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98226677
124CMYC_18555785_Chip-Seq_ESCs_Mouse0.98062653
125LXR_22292898_ChIP-Seq_THP-1_Human0.95890280
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95122006
127TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94703352
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94585539
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94452445
130* ELK3_25401928_ChIP-Seq_HUVEC_Human0.94438147
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94395645
132FUS_26573619_Chip-Seq_HEK293_Human0.94373608
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.94249262
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93144919
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92961104
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.92835914
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92811299
138CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92564273
139SPI1_23127762_ChIP-Seq_K562_Human0.92148321
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92037362
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91856134
142STAT1_20625510_ChIP-Seq_HELA_Human0.91450935
143RUNX2_22187159_ChIP-Seq_PCA_Human0.90689107
144EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90557089
145RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90557089
146P300_18555785_Chip-Seq_ESCs_Mouse0.90541854
147CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90427472
148CTCF_20526341_ChIP-Seq_ESCs_Human0.88985245
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88728116
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.88620212
151* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87589969
152SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87084383
153NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86604114
154SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85434622
155IRF1_19129219_ChIP-ChIP_H3396_Human0.84314414
156OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83999946
157SPI1_23547873_ChIP-Seq_NB4_Human0.83372824
158CTCF_21964334_Chip-Seq_Bcells_Human0.83074364
159SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83061744
160SOX2_20726797_ChIP-Seq_SW620_Human0.82987198
161NANOG_20526341_ChIP-Seq_ESCs_Human0.82932608
162CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82046438
163STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81862487
164VDR_22108803_ChIP-Seq_LS180_Human0.81511186
165SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80616923
166NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80494979
167PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79197967
168BCOR_27268052_Chip-Seq_Bcells_Human0.77810797
169* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77485090
170RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76530933
171SA1_22415368_ChIP-Seq_MEFs_Mouse0.76472565
172SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76427907
173TP53_22127205_ChIP-Seq_IMR90_Human0.76380101
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76212231
175LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75713481
176* BCL6_27268052_Chip-Seq_Bcells_Human0.75456981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system3.77821222
2MP0003011_delayed_dark_adaptation3.44211651
3MP0002254_reproductive_system_inflammat3.42999319
4MP0002332_abnormal_exercise_endurance2.92295413
5MP0005464_abnormal_platelet_physiology2.89404681
6MP0000343_altered_response_to2.85930877
7MP0000749_muscle_degeneration2.58709496
8MP0009764_decreased_sensitivity_to2.55057261
9MP0006082_CNS_inflammation2.53885160
10MP0002837_dystrophic_cardiac_calcinosis2.20523044
11MP0001800_abnormal_humoral_immune2.20448566
12MP0002452_abnormal_antigen_presenting2.20254889
13MP0006054_spinal_hemorrhage2.16838645
14MP0002723_abnormal_immune_serum2.14063567
15MP0000685_abnormal_immune_system2.12853402
16MP0000569_abnormal_digit_pigmentation2.05058935
17MP0003279_aneurysm1.93185865
18MP0004084_abnormal_cardiac_muscle1.91028258
19MP0003828_pulmonary_edema1.88344656
20MP0003195_calcinosis1.88342914
21MP0000920_abnormal_myelination1.83572113
22MP0002420_abnormal_adaptive_immunity1.82890619
23MP0008004_abnormal_stomach_pH1.82585910
24MP0001819_abnormal_immune_cell1.81363600
25MP0006035_abnormal_mitochondrial_morpho1.78776771
26MP0005257_abnormal_intraocular_pressure1.77827115
27MP0003122_maternal_imprinting1.77597475
28MP0003436_decreased_susceptibility_to1.74985386
29MP0009840_abnormal_foam_cell1.74800530
30MP0000750_abnormal_muscle_regeneration1.73301560
31MP0008438_abnormal_cutaneous_collagen1.70290344
32MP0005058_abnormal_lysosome_morphology1.68027157
33MP0001845_abnormal_inflammatory_respons1.67147032
34MP0003300_gastrointestinal_ulcer1.65538065
35MP0003137_abnormal_impulse_conducting1.62415522
36MP0000465_gastrointestinal_hemorrhage1.60485018
37MP0008775_abnormal_heart_ventricle1.60400685
38MP0004215_abnormal_myocardial_fiber1.59431981
39MP0002972_abnormal_cardiac_muscle1.57820663
40MP0002148_abnormal_hypersensitivity_rea1.56936650
41MP0009785_altered_susceptibility_to1.56922556
42MP0001905_abnormal_dopamine_level1.56256378
43MP0004036_abnormal_muscle_relaxation1.54979920
44MP0003950_abnormal_plasma_membrane1.49098372
45MP0001545_abnormal_hematopoietic_system1.48454794
46MP0005397_hematopoietic_system_phenotyp1.48454794
47MP0005000_abnormal_immune_tolerance1.45782388
48MP0005623_abnormal_meninges_morphology1.45422258
49MP0002127_abnormal_cardiovascular_syste1.45066017
50MP0005330_cardiomyopathy1.44309979
51MP0000751_myopathy1.43343874
52MP0002138_abnormal_hepatobiliary_system1.42668258
53MP0003724_increased_susceptibility_to1.41911268
54MP0003075_altered_response_to1.40222522
55MP0003646_muscle_fatigue1.39948635
56MP0003183_abnormal_peptide_metabolism1.39063807
57MP0002295_abnormal_pulmonary_circulatio1.36168945
58MP0005394_taste/olfaction_phenotype1.35397998
59MP0005499_abnormal_olfactory_system1.35397998
60MP0005165_increased_susceptibility_to1.35330651
61MP0002998_abnormal_bone_remodeling1.33113769
62MP0005164_abnormal_response_to1.32482391
63MP0003186_abnormal_redox_activity1.32387511
64MP0008469_abnormal_protein_level1.31915215
65MP0001835_abnormal_antigen_presentation1.31328450
66MP0004947_skin_inflammation1.30125562
67MP0010155_abnormal_intestine_physiology1.29976661
68MP0004510_myositis1.29531369
69MP0005075_abnormal_melanosome_morpholog1.29250623
70MP0004272_abnormal_basement_membrane1.27041724
71MP0003634_abnormal_glial_cell1.26626390
72MP0000716_abnormal_immune_system1.25674215
73MP0003690_abnormal_glial_cell1.23567204
74MP0002735_abnormal_chemical_nociception1.22001351
75MP0005647_abnormal_sex_gland1.19882466
76MP0001853_heart_inflammation1.19649567
77MP0004883_abnormal_blood_vessel1.18977665
78MP0005025_abnormal_response_to1.17916985
79MP0002733_abnormal_thermal_nociception1.16709796
80MP0002277_abnormal_respiratory_mucosa1.15520907
81MP0006036_abnormal_mitochondrial_physio1.15107893
82MP0006276_abnormal_autonomic_nervous1.14563825
83MP0000015_abnormal_ear_pigmentation1.14432157
84MP0000372_irregular_coat_pigmentation1.12654483
85MP0001663_abnormal_digestive_system1.12455437
86MP0000759_abnormal_skeletal_muscle1.12366849
87MP0003656_abnormal_erythrocyte_physiolo1.11730380
88MP0004087_abnormal_muscle_fiber1.11078619
89MP0005174_abnormal_tail_pigmentation1.09993393
90MP0002419_abnormal_innate_immunity1.09945832
91MP0005310_abnormal_salivary_gland1.09558399
92MP0000689_abnormal_spleen_morphology1.07974153
93MP0009765_abnormal_xenobiotic_induced1.07000714
94MP0002398_abnormal_bone_marrow1.06947318
95MP0005620_abnormal_muscle_contractility1.05622786
96MP0001970_abnormal_pain_threshold1.05479356
97MP0004270_analgesia1.05389066
98MP0009278_abnormal_bone_marrow1.02347630
99MP0003448_altered_tumor_morphology1.02170163
100MP0004043_abnormal_pH_regulation1.01944547
101MP0001727_abnormal_embryo_implantation1.01890896
102MP0003221_abnormal_cardiomyocyte_apopto1.00717337
103MP0002909_abnormal_adrenal_gland1.00221984
104MP0004264_abnormal_extraembryonic_tissu1.00088423
105MP0000767_abnormal_smooth_muscle1.00041388
106MP0004130_abnormal_muscle_cell0.99618892
107MP0004085_abnormal_heartbeat0.97803675
108MP0001968_abnormal_touch/_nociception0.96528601
109MP0001529_abnormal_vocalization0.95528293
110MP0001533_abnormal_skeleton_physiology0.95246234
111MP0005385_cardiovascular_system_phenoty0.95227688
112MP0001544_abnormal_cardiovascular_syste0.95227688
113MP0002736_abnormal_nociception_after0.94531434
114MP0002734_abnormal_mechanical_nocicepti0.94121333
115MP0001542_abnormal_bone_strength0.94045685
116MP0009333_abnormal_splenocyte_physiolog0.93542039
117MP0002106_abnormal_muscle_physiology0.93514714
118MP0005166_decreased_susceptibility_to0.91340790
119MP0002429_abnormal_blood_cell0.90894544
120MP0003172_abnormal_lysosome_physiology0.90561055
121MP0000604_amyloidosis0.88674983
122MP0010386_abnormal_urinary_bladder0.88325742
123MP0002405_respiratory_system_inflammati0.86592462
124MP0005390_skeleton_phenotype0.85831772
125MP0003329_amyloid_beta_deposits0.85492288
126MP0000230_abnormal_systemic_arterial0.84699435
127MP0002722_abnormal_immune_system0.84309486
128MP0005671_abnormal_response_to0.83926567
129MP0005167_abnormal_blood-brain_barrier0.82268932
130MP0003191_abnormal_cellular_cholesterol0.81440293
131MP0005369_muscle_phenotype0.80472646
132MP0002102_abnormal_ear_morphology0.80429023
133MP0003806_abnormal_nucleotide_metabolis0.79549630
134MP0009763_increased_sensitivity_to0.79490475
135MP0001790_abnormal_immune_system0.79158050
136MP0005387_immune_system_phenotype0.79158050
137MP0004484_altered_response_of0.78251226
138MP0003303_peritoneal_inflammation0.78110603
139MP0000249_abnormal_blood_vessel0.77073188
140MP0000371_diluted_coat_color0.76097664
141MP0005508_abnormal_skeleton_morphology0.75154792
142MP0006292_abnormal_olfactory_placode0.75090638
143MP0005266_abnormal_metabolism0.72873489
144MP0005197_abnormal_uvea_morphology0.72846791
145MP0001986_abnormal_taste_sensitivity0.71218961
146MP0008877_abnormal_DNA_methylation0.69922355
147MP0005084_abnormal_gallbladder_morpholo0.67711740
148MP0005248_abnormal_Harderian_gland0.66284086
149MP0001851_eye_inflammation0.66099682
150MP0003633_abnormal_nervous_system0.65200933
151MP0002653_abnormal_ependyma_morphology0.63297627
152MP0002132_abnormal_respiratory_system0.61574341
153MP0002693_abnormal_pancreas_physiology0.61390420
154MP0005595_abnormal_vascular_smooth0.60397139
155MP0004142_abnormal_muscle_tone0.60162084
156MP0002095_abnormal_skin_pigmentation0.59679695
157MP0008260_abnormal_autophagy0.58058874
158MP0000858_altered_metastatic_potential0.57767079
159MP0001324_abnormal_eye_pigmentation0.57100623

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.69736996
2Bilateral microphthalmos (HP:0007633)4.61343239
3Multiple enchondromatosis (HP:0005701)4.27058924
4Petechiae (HP:0000967)3.87310561
5Retrobulbar optic neuritis (HP:0100654)3.83387162
6Optic neuritis (HP:0100653)3.83387162
7Prolonged bleeding time (HP:0003010)3.62239072
8Increased serum pyruvate (HP:0003542)3.50587084
9Abnormality of glycolysis (HP:0004366)3.50587084
10Testicular atrophy (HP:0000029)3.48271389
11Sensory axonal neuropathy (HP:0003390)3.46070482
12Orchitis (HP:0100796)3.46005419
13Disinhibition (HP:0000734)3.45948926
14Abnormality of the vasculature of the conjunctiva (HP:0008054)3.40226102
15Ventricular tachycardia (HP:0004756)3.35784593
16Abnormality of glycolipid metabolism (HP:0010969)3.24708777
17Abnormality of liposaccharide metabolism (HP:0010968)3.24708777
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.24708777
19Acute necrotizing encephalopathy (HP:0006965)3.23332025
20Myositis (HP:0100614)3.13556112
21Difficulty running (HP:0009046)2.98772988
22Vacuolated lymphocytes (HP:0001922)2.95800794
23Mediastinal lymphadenopathy (HP:0100721)2.94400514
24Ragged-red muscle fibers (HP:0003200)2.93544745
25Increased connective tissue (HP:0009025)2.93532130
26Conjunctival telangiectasia (HP:0000524)2.89485881
27Autoimmune thrombocytopenia (HP:0001973)2.88905476
28Hematochezia (HP:0002573)2.88648623
29Axonal loss (HP:0003447)2.88428983
30Elevated erythrocyte sedimentation rate (HP:0003565)2.86728954
31Recurrent gram-negative bacterial infections (HP:0005420)2.85215873
32Spontaneous hematomas (HP:0007420)2.85196620
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83598017
34Gingival bleeding (HP:0000225)2.79527049
35Abnormal mitochondria in muscle tissue (HP:0008316)2.78422271
36Inappropriate behavior (HP:0000719)2.74622393
37Hypochromic microcytic anemia (HP:0004840)2.73277117
38Recurrent abscess formation (HP:0002722)2.72679765
39Epistaxis (HP:0000421)2.68754929
403-Methylglutaconic aciduria (HP:0003535)2.63367875
41Dysostosis multiplex (HP:0000943)2.62594992
42Mitochondrial inheritance (HP:0001427)2.61315363
43Progressive macrocephaly (HP:0004481)2.57974410
44Anomalous pulmonary venous return (HP:0010772)2.57168887
45Abolished electroretinogram (ERG) (HP:0000550)2.56555852
46EMG: myopathic abnormalities (HP:0003458)2.56055183
47Recurrent fungal infections (HP:0002841)2.53390072
48Eczematoid dermatitis (HP:0000976)2.51829083
49Keratoconjunctivitis sicca (HP:0001097)2.51817527
50Keratoconjunctivitis (HP:0001096)2.48215807
51Mutism (HP:0002300)2.46412599
52Partial duplication of thumb phalanx (HP:0009944)2.46383385
53Recurrent skin infections (HP:0001581)2.45322365
54Exercise-induced muscle cramps (HP:0003710)2.45146782
55Aplasia/Hypoplasia of the fovea (HP:0008060)2.43677264
56Hypoplasia of the fovea (HP:0007750)2.43677264
57Abnormal pupillary function (HP:0007686)2.43354364
58Myotonia (HP:0002486)2.42670321
59Neuroendocrine neoplasm (HP:0100634)2.42301883
60Episodic fever (HP:0001954)2.41445791
61Pancreatic cysts (HP:0001737)2.41019922
62Abnormality of the pulmonary veins (HP:0011718)2.39650267
63Reduced antithrombin III activity (HP:0001976)2.38669958
64Increased cerebral lipofuscin (HP:0011813)2.38170471
65Sudden death (HP:0001699)2.36854853
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.36174721
67Polyneuropathy (HP:0001271)2.35753522
68Encephalitis (HP:0002383)2.34350589
69Rectovaginal fistula (HP:0000143)2.34007128
70Rectal fistula (HP:0100590)2.34007128
71Abnormal platelet volume (HP:0011876)2.33878858
72Muscle fiber splitting (HP:0003555)2.33317991
73Acute encephalopathy (HP:0006846)2.33235904
74Abnormality of T cell number (HP:0011839)2.32139573
75Increased CSF lactate (HP:0002490)2.31954154
76Fasciculations (HP:0002380)2.31751669
77Vaginal fistula (HP:0004320)2.31025203
78Leukocytosis (HP:0001974)2.30226034
79Increased variability in muscle fiber diameter (HP:0003557)2.29123298
80Congenital stationary night blindness (HP:0007642)2.28783433
81Atrial fibrillation (HP:0005110)2.28450089
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27174393
83Peritonitis (HP:0002586)2.26941594
84Congenital sensorineural hearing impairment (HP:0008527)2.26481912
85Pulmonary infiltrates (HP:0002113)2.24540249
86Hyperventilation (HP:0002883)2.22890854
87Abnormal cartilage morphology (HP:0002763)2.22825213
88Abnormality of macrophages (HP:0004311)2.20694594
89Increased mean platelet volume (HP:0011877)2.20543134
90T lymphocytopenia (HP:0005403)2.19285572
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18221001
92Primary atrial arrhythmia (HP:0001692)2.16432932
93Vasculitis (HP:0002633)2.15432975
94True hermaphroditism (HP:0010459)2.14073706
95Recurrent bacterial skin infections (HP:0005406)2.13819659
96Rib fusion (HP:0000902)2.13357004
97Obstructive lung disease (HP:0006536)2.13317736
98Chronic obstructive pulmonary disease (HP:0006510)2.13317736
99Supraventricular tachycardia (HP:0004755)2.11902967
100Recurrent cutaneous fungal infections (HP:0011370)2.11566917
101Chronic mucocutaneous candidiasis (HP:0002728)2.11566917
102Decreased central vision (HP:0007663)2.11357279
103Partial duplication of the phalanx of hand (HP:0009999)2.10432854
104Hemoptysis (HP:0002105)2.10073592
105Amyloidosis (HP:0011034)2.09385542
106Renal Fanconi syndrome (HP:0001994)2.09368190
107Fused cervical vertebrae (HP:0002949)2.08223172
108Supraventricular arrhythmia (HP:0005115)2.08216693
109Hepatocellular necrosis (HP:0001404)2.07663922
110Neurofibrillary tangles (HP:0002185)2.06491638
111Progressive muscle weakness (HP:0003323)2.06385376
112Achilles tendon contracture (HP:0001771)2.04328317
113Pheochromocytoma (HP:0002666)2.01409094
114Hypokinesia (HP:0002375)2.01276420
115Hepatoblastoma (HP:0002884)2.00277576
116Pancreatic fibrosis (HP:0100732)1.99950077
117Stomach cancer (HP:0012126)1.98693153
118Trismus (HP:0000211)1.98600141
119Amblyopia (HP:0000646)1.97321412
120Loss of speech (HP:0002371)1.96615940
121Dyschromatopsia (HP:0007641)1.96239351
122Vertebral compression fractures (HP:0002953)1.95943846
123Failure to thrive in infancy (HP:0001531)1.95152136
124Diminished motivation (HP:0000745)1.94270170
125Paralysis (HP:0003470)1.94252461
126Nasolacrimal duct obstruction (HP:0000579)1.94246872
127Rapidly progressive (HP:0003678)1.94196976
128Arterial thrombosis (HP:0004420)1.94050819
129Steppage gait (HP:0003376)1.93202417
130Menorrhagia (HP:0000132)1.92425427
131Agitation (HP:0000713)1.90998222
132Abnormality of skeletal muscle fiber size (HP:0012084)1.90246556
133Hyperinsulinemic hypoglycemia (HP:0000825)1.90209964
134Exercise intolerance (HP:0003546)1.90184976
135Apathy (HP:0000741)1.89748596
136Bradycardia (HP:0001662)1.88747305
137Concave nail (HP:0001598)1.88568706
138Increased IgM level (HP:0003496)1.87800798
139Retinal dysplasia (HP:0007973)1.87508969
140Cerebral hemorrhage (HP:0001342)1.87356253
141Myocardial infarction (HP:0001658)1.87308248
142Respiratory failure (HP:0002878)1.87235910
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.86817326
144Mucosal telangiectasiae (HP:0100579)1.85956820
145Gastrointestinal infarctions (HP:0005244)1.85067158
146Abnormality of midbrain morphology (HP:0002418)1.84314937
147Molar tooth sign on MRI (HP:0002419)1.84314937
148Generalized hypotonia (HP:0001290)1.83075841
149Autoimmune hemolytic anemia (HP:0001890)1.82625409
150Purpura (HP:0000979)1.82624012
151Degeneration of anterior horn cells (HP:0002398)1.82487728
152Abnormality of the anterior horn cell (HP:0006802)1.82487728
153Chronic otitis media (HP:0000389)1.82315032
154Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81847700
155Neoplasm of the tracheobronchial system (HP:0100552)1.81831512
156Albinism (HP:0001022)1.81359511
157Horizontal nystagmus (HP:0000666)1.80796368
158Abnormality of the nasal mucosa (HP:0000433)1.80461411
159Gaze-evoked nystagmus (HP:0000640)1.80208858
160Difficulty walking (HP:0002355)1.79993951
161Hepatic necrosis (HP:0002605)1.79760200
162Muscle fibrillation (HP:0010546)1.79646938
163Metaphyseal irregularity (HP:0003025)1.78948704
164Absent/shortened dynein arms (HP:0200106)1.78727866
165Dynein arm defect of respiratory motile cilia (HP:0012255)1.78727866
166Urticaria (HP:0001025)1.78692975
167Abnormality of secondary sexual hair (HP:0009888)1.78642676
168Abnormality of the axillary hair (HP:0100134)1.78642676
169Alveolar cell carcinoma (HP:0006519)1.77373745
170Anorexia (HP:0002039)1.77365197
171Abnormality of the prostate (HP:0008775)1.77231551
172Upper motor neuron abnormality (HP:0002127)1.76308724
173Genetic anticipation (HP:0003743)1.75874285
174Thick nail (HP:0001805)1.75235891
175Vertigo (HP:0002321)1.75160204
176Attenuation of retinal blood vessels (HP:0007843)1.73560859
177Gangrene (HP:0100758)1.73260342
178Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73082820
179Abnormality of polysaccharide metabolism (HP:0011012)1.73082820
180Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73082820
181Eosinophilia (HP:0001880)1.72454351
182Abnormality of the salivary glands (HP:0010286)1.71767163
183Abnormality of the fovea (HP:0000493)1.71700706
184Abnormality of transition element cation homeostasis (HP:0011030)1.70892635
185Type I transferrin isoform profile (HP:0003642)1.70520000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK55.32308062
2ERN13.86610574
3FRK3.74401750
4GRK73.67928061
5ADRBK23.53673620
6ACVR1B3.52028855
7GRK63.03351538
8CSF1R2.49005232
9TAOK32.45349657
10TGFBR22.41650975
11NTRK12.40240253
12CDK122.26371263
13PIM22.22290424
14MATK2.20956259
15GRK12.14234215
16MOS2.06924913
17ARAF2.01622692
18MAP3K121.85762027
19MYLK1.85286984
20IRAK11.84167321
21TXK1.84086097
22RIPK41.71428054
23MAPK71.69522204
24STK391.69200736
25LIMK11.67121925
26BMPR1B1.60500262
27IRAK31.60302960
28MARK31.56053401
29TEC1.51685731
30MST41.49055002
31IKBKE1.48601783
32PRPF4B1.46688109
33ADRBK11.46348740
34WNK11.44847095
35NME21.42869818
36PRKG21.33705566
37BMPR21.33191997
38SGK21.33100897
39KIT1.29108701
40PIK3CG1.27623880
41MAP2K31.25040536
42BLK1.23346544
43CASK1.23161862
44TRIM281.22713726
45MAP3K31.21704902
46TYRO31.20481161
47MUSK1.19287367
48LMTK21.19249330
49PHKG21.18413809
50PHKG11.18413809
51PBK1.17308500
52MAP3K51.13490305
53IRAK21.13222430
54FES1.11928474
55SIK31.11853361
56TAOK21.11797626
57TESK21.09802434
58BTK1.08857490
59MAP4K11.07911169
60CHUK1.06293784
61PLK21.05288939
62NEK91.04299378
63MAPK121.00399225
64YES10.99451217
65TTN0.98796993
66ABL20.98421616
67TBK10.97970090
68CSK0.95303402
69SGK30.92680752
70TESK10.89190206
71KDR0.89137287
72WNK30.88295834
73TGFBR10.88012226
74TAOK10.86696605
75TLK10.86536703
76BRSK20.85141882
77CAMKK20.85103968
78STK240.83345705
79PAK40.82862399
80DAPK30.79664441
81JAK30.79019420
82SIK20.78857072
83STK100.78396146
84NUAK10.77801047
85DYRK30.77491857
86DAPK20.76892074
87DDR20.76421225
88KSR20.75199447
89MET0.75113013
90MAP2K40.72247302
91WNK40.69907268
92PTK2B0.66879628
93IRAK40.64064724
94EPHB10.63874776
95TRIB30.63406836
96JAK20.63053412
97MKNK20.60246341
98BCR0.60234264
99DYRK20.59622224
100IKBKB0.59329674
101CAMK40.58605854
102CAMK1D0.57815835
103ERBB30.57788259
104JAK10.57458136
105STK30.57453733
106ITK0.57358471
107PRKCD0.57132032
108FGR0.56527638
109HIPK20.55737100
110TNIK0.55602116
111MAP2K20.54648995
112SGK2230.53979321
113SGK4940.53979321
114IGF1R0.53623284
115MAP2K60.52283684
116PAK30.51568239
117MAPKAPK50.51144335
118CAMK1G0.50809701
119PDGFRB0.50525848
120MAP3K90.50364122
121MAP3K110.49998422
122PDK20.48868960
123ABL10.47692912
124MST1R0.46238333
125SYK0.45622420
126INSRR0.44267416
127PIM10.43114284
128MAP2K10.42680188
129MARK20.41939593
130BMX0.41915005
131CDK140.41891893
132EPHA30.41848633
133RPS6KA60.41330704
134MAPK130.41172514
135NME10.40959430
136PINK10.39969177
137OXSR10.39721222
138ILK0.38715719
139TRPM70.38526777
140TYK20.38465661
141LCK0.38315173
142PRKCE0.37506004
143ZAK0.37053068
144MAP3K130.35887635
145MAPK40.35107275
146TIE10.34033084
147DMPK0.33851862
148MAPKAPK30.32271086
149MAP3K140.32234938
150FYN0.32142937
151ROCK20.32029554
152MAP3K40.32003271
153PKN10.31976964
154ZAP700.31917564
155PRKD10.31547489
156OBSCN0.30871335
157CDC42BPA0.30401039
158PRKCQ0.29807784
159HCK0.28340672
160TNK20.27847093
161PDK40.27614785
162PDK30.27614785
163LYN0.27574515
164FGFR30.27432112

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.09267449
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.45425944
3Parkinsons disease_Homo sapiens_hsa050123.29454139
4Vitamin B6 metabolism_Homo sapiens_hsa007502.90065591
5Alzheimers disease_Homo sapiens_hsa050102.56509910
6Staphylococcus aureus infection_Homo sapiens_hsa051502.50036685
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.39936277
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.39139816
9Cardiac muscle contraction_Homo sapiens_hsa042602.34147169
10Collecting duct acid secretion_Homo sapiens_hsa049662.28538489
11Huntingtons disease_Homo sapiens_hsa050161.97773633
12Arachidonic acid metabolism_Homo sapiens_hsa005901.82103778
13Lysosome_Homo sapiens_hsa041421.81617498
14Rheumatoid arthritis_Homo sapiens_hsa053231.77961038
15TNF signaling pathway_Homo sapiens_hsa046681.74194366
16Phagosome_Homo sapiens_hsa041451.66809388
17Other glycan degradation_Homo sapiens_hsa005111.62148115
18Autoimmune thyroid disease_Homo sapiens_hsa053201.61002780
19Ether lipid metabolism_Homo sapiens_hsa005651.60279503
20Protein export_Homo sapiens_hsa030601.54560452
21Type I diabetes mellitus_Homo sapiens_hsa049401.49240608
22Malaria_Homo sapiens_hsa051441.47532532
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46861518
24Vibrio cholerae infection_Homo sapiens_hsa051101.42541700
25Fructose and mannose metabolism_Homo sapiens_hsa000511.41944009
26Leishmaniasis_Homo sapiens_hsa051401.40932003
27Proteasome_Homo sapiens_hsa030501.38832647
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25723445
29Steroid biosynthesis_Homo sapiens_hsa001001.24695236
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24587863
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23243104
32Linoleic acid metabolism_Homo sapiens_hsa005911.20697020
33Galactose metabolism_Homo sapiens_hsa000521.20179924
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19967580
35Measles_Homo sapiens_hsa051621.18814600
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16547960
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14155667
38Fatty acid elongation_Homo sapiens_hsa000621.13553488
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13056440
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.12597215
41Influenza A_Homo sapiens_hsa051641.10549113
42Salmonella infection_Homo sapiens_hsa051321.09205136
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04650474
44Tuberculosis_Homo sapiens_hsa051521.03603362
45Sulfur relay system_Homo sapiens_hsa041221.03495071
46T cell receptor signaling pathway_Homo sapiens_hsa046601.03072349
47Sphingolipid metabolism_Homo sapiens_hsa006001.02836014
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01330363
49Antigen processing and presentation_Homo sapiens_hsa046121.01151263
50Synaptic vesicle cycle_Homo sapiens_hsa047210.96996911
51Pertussis_Homo sapiens_hsa051330.96916006
52Dilated cardiomyopathy_Homo sapiens_hsa054140.95473367
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.95404240
54Shigellosis_Homo sapiens_hsa051310.86430591
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82739493
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.82250180
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.82080299
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78956769
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78376975
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78309583
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.77002331
62Serotonergic synapse_Homo sapiens_hsa047260.76812470
63Endocytosis_Homo sapiens_hsa041440.76772437
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76303593
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76193564
66Nitrogen metabolism_Homo sapiens_hsa009100.74900035
67Ribosome_Homo sapiens_hsa030100.74579655
68Regulation of autophagy_Homo sapiens_hsa041400.74538052
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73864460
70African trypanosomiasis_Homo sapiens_hsa051430.73391403
71Hepatitis B_Homo sapiens_hsa051610.71936868
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70930496
73VEGF signaling pathway_Homo sapiens_hsa043700.69639972
74Herpes simplex infection_Homo sapiens_hsa051680.68583169
75Prolactin signaling pathway_Homo sapiens_hsa049170.67904392
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67202636
77Legionellosis_Homo sapiens_hsa051340.66912085
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.66524700
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.66001815
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64883820
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64361953
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63950563
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63591901
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63327025
85Sulfur metabolism_Homo sapiens_hsa009200.63198426
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62970078
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62791124
88Viral myocarditis_Homo sapiens_hsa054160.62439088
89Hepatitis C_Homo sapiens_hsa051600.61530309
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61056599
91Apoptosis_Homo sapiens_hsa042100.60338133
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59094542
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58581774
94FoxO signaling pathway_Homo sapiens_hsa040680.57952388
95MAPK signaling pathway_Homo sapiens_hsa040100.57895357
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55690873
97Primary immunodeficiency_Homo sapiens_hsa053400.55344827
98Osteoclast differentiation_Homo sapiens_hsa043800.54821501
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53233088
100Amoebiasis_Homo sapiens_hsa051460.52865330
101Type II diabetes mellitus_Homo sapiens_hsa049300.52407915
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51893988
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51826167
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51818576
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51190599
106Ras signaling pathway_Homo sapiens_hsa040140.50907877
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49432649
108Selenocompound metabolism_Homo sapiens_hsa004500.49125154
109Asthma_Homo sapiens_hsa053100.47808090
110Allograft rejection_Homo sapiens_hsa053300.46466312
111Rap1 signaling pathway_Homo sapiens_hsa040150.44039073
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.42607706
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42528439
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42059442
115Long-term depression_Homo sapiens_hsa047300.42038301
116Platelet activation_Homo sapiens_hsa046110.41235054
117Graft-versus-host disease_Homo sapiens_hsa053320.40406675
118Ovarian steroidogenesis_Homo sapiens_hsa049130.39265347
119Hematopoietic cell lineage_Homo sapiens_hsa046400.38462204
120Complement and coagulation cascades_Homo sapiens_hsa046100.38219566
121Toxoplasmosis_Homo sapiens_hsa051450.38075601
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37002306
123B cell receptor signaling pathway_Homo sapiens_hsa046620.36778563
124Phototransduction_Homo sapiens_hsa047440.36405805
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36329539
126Chemokine signaling pathway_Homo sapiens_hsa040620.35905555
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.35640475
128Mineral absorption_Homo sapiens_hsa049780.34010945
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33662049
130Olfactory transduction_Homo sapiens_hsa047400.33465808
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.32555945
132Focal adhesion_Homo sapiens_hsa045100.31538573
133Axon guidance_Homo sapiens_hsa043600.31501944
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.31210582
135Tryptophan metabolism_Homo sapiens_hsa003800.31141472
136Renal cell carcinoma_Homo sapiens_hsa052110.30683571
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29915161
138Dorso-ventral axis formation_Homo sapiens_hsa043200.29862338

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »