RITA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)4.96523316
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.76911888
3proline biosynthetic process (GO:0006561)4.60204566
4NADH metabolic process (GO:0006734)4.49090530
5DNA strand elongation involved in DNA replication (GO:0006271)4.40398844
6DNA strand elongation (GO:0022616)4.35146271
7ATP synthesis coupled proton transport (GO:0015986)4.29269323
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.29269323
9telomere maintenance via semi-conservative replication (GO:0032201)4.28183928
10protein maturation by protein folding (GO:0022417)4.26122742
11DNA unwinding involved in DNA replication (GO:0006268)4.12654053
12chaperone-mediated protein transport (GO:0072321)4.03749860
13nucleobase-containing small molecule interconversion (GO:0015949)4.01436377
14positive regulation of mitochondrial fission (GO:0090141)3.95680412
15regulation of mitochondrial translation (GO:0070129)3.89864972
16cullin deneddylation (GO:0010388)3.83234854
177-methylguanosine mRNA capping (GO:0006370)3.82863296
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.68861642
19synaptic vesicle exocytosis (GO:0016079)3.68505054
207-methylguanosine RNA capping (GO:0009452)3.67054812
21RNA capping (GO:0036260)3.67054812
22pseudouridine synthesis (GO:0001522)3.63971605
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.58725587
24establishment of protein localization to mitochondrion (GO:0072655)3.58583840
25protein targeting to mitochondrion (GO:0006626)3.56319995
26protein deneddylation (GO:0000338)3.54497151
27pyrimidine nucleotide catabolic process (GO:0006244)3.53391508
28termination of RNA polymerase III transcription (GO:0006386)3.48371819
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.48371819
30negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.47126563
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.46626740
32pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.42163216
33respiratory electron transport chain (GO:0022904)3.42010540
34regulation of mammary gland epithelial cell proliferation (GO:0033599)3.41789818
35histone arginine methylation (GO:0034969)3.41276167
36electron transport chain (GO:0022900)3.39040126
37negative regulation of microtubule polymerization (GO:0031115)3.38990257
38ribosomal small subunit assembly (GO:0000028)3.38644716
39establishment of viral latency (GO:0019043)3.38457891
40oxidative phosphorylation (GO:0006119)3.36849331
41viral transcription (GO:0019083)3.36546209
42regulation of translational fidelity (GO:0006450)3.34182306
43protein localization to mitochondrion (GO:0070585)3.31118603
44mitochondrial fusion (GO:0008053)3.30892371
45proline metabolic process (GO:0006560)3.30491279
46mitochondrial respiratory chain complex assembly (GO:0033108)3.30484525
47purine nucleobase biosynthetic process (GO:0009113)3.30128959
48protein neddylation (GO:0045116)3.29711877
49DNA replication initiation (GO:0006270)3.26725762
50heterochromatin organization (GO:0070828)3.25560715
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.23353968
52protein complex biogenesis (GO:0070271)3.23226305
53rRNA transcription (GO:0009303)3.23101288
54regulation of translational termination (GO:0006449)3.23023679
55DNA deamination (GO:0045006)3.22307717
56L-serine metabolic process (GO:0006563)3.21880473
57telomere maintenance via recombination (GO:0000722)3.21798820
58proteasome assembly (GO:0043248)3.19923181
59translational termination (GO:0006415)3.19551301
60oxaloacetate metabolic process (GO:0006107)3.19507403
61ribosome biogenesis (GO:0042254)3.19294824
62GDP-mannose metabolic process (GO:0019673)3.17948055
63nucleobase biosynthetic process (GO:0046112)3.17792934
64transcription from RNA polymerase I promoter (GO:0006360)3.17468009
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16451111
66peptidyl-arginine omega-N-methylation (GO:0035247)3.15380613
67pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.14066623
68translational elongation (GO:0006414)3.13512045
69rRNA modification (GO:0000154)3.12978543
70nuclear envelope reassembly (GO:0031468)3.12611680
71mitotic nuclear envelope reassembly (GO:0007084)3.12611680
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12198031
73transcription elongation from RNA polymerase I promoter (GO:0006362)3.10945520
74base-excision repair (GO:0006284)3.09362347
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07149121
76pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.04881097
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04825533
78regulation of mitochondrial fission (GO:0090140)3.04332846
79guanosine-containing compound biosynthetic process (GO:1901070)3.03690792
80protein-cofactor linkage (GO:0018065)3.03220816
81energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.98895502
82ATP hydrolysis coupled proton transport (GO:0015991)2.98895502
83transcription from mitochondrial promoter (GO:0006390)2.97938323
84nucleotide salvage (GO:0043173)2.97743095
85mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.97203492
86pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.96986625
87Golgi transport vesicle coating (GO:0048200)2.96890655
88COPI coating of Golgi vesicle (GO:0048205)2.96890655
89telomere maintenance via telomere lengthening (GO:0010833)2.96701070
90mitotic chromosome condensation (GO:0007076)2.95872031
91positive regulation of synapse maturation (GO:0090129)2.95189689
92amino acid salvage (GO:0043102)2.94719315
93L-methionine salvage (GO:0071267)2.94719315
94L-methionine biosynthetic process (GO:0071265)2.94719315
95ribosome assembly (GO:0042255)2.94548113
96mitotic recombination (GO:0006312)2.93127306
97termination of RNA polymerase I transcription (GO:0006363)2.92084750
98regulation of short-term neuronal synaptic plasticity (GO:0048172)2.91833056
99tricarboxylic acid cycle (GO:0006099)2.91260416
100negative regulation of ligase activity (GO:0051352)2.90761050
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90761050
102nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90737403
103negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.89297778
104pentose-phosphate shunt (GO:0006098)2.87938639
105base-excision repair, AP site formation (GO:0006285)2.86512502
106glutamate secretion (GO:0014047)2.86367720
107regulation of cellular amino acid metabolic process (GO:0006521)2.86080570
108transcription initiation from RNA polymerase I promoter (GO:0006361)2.84376274
109gluconeogenesis (GO:0006094)2.83818265
110CTP metabolic process (GO:0046036)2.83387190
111CTP biosynthetic process (GO:0006241)2.83387190
112cellular component biogenesis (GO:0044085)2.82967392
113protein retention in ER lumen (GO:0006621)2.82321876
114mitochondrial fission (GO:0000266)2.81146234
115nucleotide-excision repair, DNA gap filling (GO:0006297)2.80977089
116maturation of 5.8S rRNA (GO:0000460)2.79315617
117viral life cycle (GO:0019058)2.78796853
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78043165
119GMP metabolic process (GO:0046037)2.77448691
120peptidyl-arginine N-methylation (GO:0035246)2.77073394
121peptidyl-arginine methylation (GO:0018216)2.77073394
122mitochondrial calcium ion transport (GO:0006851)2.76760873
123IMP biosynthetic process (GO:0006188)2.76707988
124SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76495348
125establishment of integrated proviral latency (GO:0075713)2.76192183
126rRNA processing (GO:0006364)2.74829417
127ribosomal large subunit biogenesis (GO:0042273)2.74346399
128UTP biosynthetic process (GO:0006228)2.74326291
129translational initiation (GO:0006413)2.73972327
130respiratory chain complex IV assembly (GO:0008535)2.73884156
131monosaccharide biosynthetic process (GO:0046364)2.73813045
132negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73650513
133formation of translation preinitiation complex (GO:0001731)2.73648011
134mitochondrial respiratory chain complex I assembly (GO:0032981)2.73598325
135NADH dehydrogenase complex assembly (GO:0010257)2.73598325
136mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73598325
137RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73281371
138tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73281371
139transcription-coupled nucleotide-excision repair (GO:0006283)2.73142483
140positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72953968
141cell migration in hindbrain (GO:0021535)2.71828593
142pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71779297
143maturation of SSU-rRNA (GO:0030490)2.71672637
144protein targeting to ER (GO:0045047)2.71458655
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70758917
146translation (GO:0006412)2.70396194
147DNA replication checkpoint (GO:0000076)2.70110996
148cotranslational protein targeting to membrane (GO:0006613)2.69131051
149tRNA methylation (GO:0030488)2.68118709
150deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.67527295
151ribonucleoprotein complex biogenesis (GO:0022613)2.67487809
152neurotransmitter-gated ion channel clustering (GO:0072578)2.65829857
153rRNA methylation (GO:0031167)2.61289205
154spliceosomal snRNP assembly (GO:0000387)2.60688897
155iron-sulfur cluster assembly (GO:0016226)2.60291619
156metallo-sulfur cluster assembly (GO:0031163)2.60291619
157DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60193027
158regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57959988
159positive regulation of ligase activity (GO:0051351)2.56889052
160protein insertion into membrane (GO:0051205)2.55968562
161protein localization to synapse (GO:0035418)2.54177725
162transferrin transport (GO:0033572)2.54123079
163vocalization behavior (GO:0071625)2.54087777
164transcription elongation from RNA polymerase II promoter (GO:0006368)2.53920391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.91875284
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.89361405
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86472837
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64071029
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.54088342
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.41168528
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.40721814
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.27762989
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26856813
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.18142225
11THAP11_20581084_ChIP-Seq_MESCs_Mouse2.90777406
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83177035
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.77930923
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77403094
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73817009
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69351316
17YY1_21170310_ChIP-Seq_MESCs_Mouse2.63574337
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56052398
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.41770956
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29343340
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19526341
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17406959
23XRN2_22483619_ChIP-Seq_HELA_Human2.15870528
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.15807721
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.15137679
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13158520
27GABP_19822575_ChIP-Seq_HepG2_Human2.12409041
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02813364
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02638542
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97280877
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93913056
32MYC_22102868_ChIP-Seq_BL_Human1.92162785
33SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.91789069
34FOXP3_21729870_ChIP-Seq_TREG_Human1.90305451
35VDR_23849224_ChIP-Seq_CD4+_Human1.86121551
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83565948
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81021596
38VDR_21846776_ChIP-Seq_THP-1_Human1.80269623
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76698471
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76290351
41DCP1A_22483619_ChIP-Seq_HELA_Human1.76034973
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73301664
43E2F7_22180533_ChIP-Seq_HELA_Human1.68204569
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66893650
45TTF2_22483619_ChIP-Seq_HELA_Human1.64144576
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.63875489
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60904436
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59877750
49LXR_22292898_ChIP-Seq_THP-1_Human1.59862437
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59493822
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51604907
52RACK7_27058665_Chip-Seq_MCF-7_Human1.44869942
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43982259
54ZNF263_19887448_ChIP-Seq_K562_Human1.42418660
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42386818
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41501250
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40496877
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37446336
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37395061
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36407886
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35399704
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35235801
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35035958
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.33977533
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.33245834
66P68_20966046_ChIP-Seq_HELA_Human1.32175789
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32122963
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31577327
69AR_21909140_ChIP-Seq_LNCAP_Human1.31265018
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29620853
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29090732
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28782764
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.27956960
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27251341
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.27135829
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26639755
77EZH2_22144423_ChIP-Seq_EOC_Human1.26184197
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.25766446
79KDM5A_27292631_Chip-Seq_BREAST_Human1.25198855
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22576899
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21812021
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21691981
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21685198
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19277620
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17980818
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17947538
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17639997
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16613276
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16152172
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15978730
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15608050
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14707609
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14215097
94TBX5_21415370_ChIP-Seq_HL-1_Mouse1.12858665
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12771414
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12021172
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.11779269
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11145767
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10791942
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09505665
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09049245
102ELK1_19687146_ChIP-ChIP_HELA_Human1.08664376
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08160121
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.07736793
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07360163
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07011684
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06018246
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.05419169
109CIITA_25753668_ChIP-Seq_RAJI_Human1.04963406
110NANOG_21062744_ChIP-ChIP_HESCs_Human1.04418511
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03602667
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03144491
113CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03066658
114OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03042938
115REST_21632747_ChIP-Seq_MESCs_Mouse1.02275799
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00277439
117SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99999711
118BCL6_27268052_Chip-Seq_Bcells_Human0.99592877
119MYC_18940864_ChIP-ChIP_HL60_Human0.99089047
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98650806
121YY1_22570637_ChIP-Seq_MALME-3M_Human0.95232997
122SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95147941
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.94101844
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93254119
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92850534
126TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92625638
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91038970
128NOTCH1_21737748_ChIP-Seq_TLL_Human0.90956384
129FOXM1_23109430_ChIP-Seq_U2OS_Human0.90950081
130FOXP1_21924763_ChIP-Seq_HESCs_Human0.90938978
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89554858
132TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88710502
133HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87128561
134PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86885813
135POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84271280
136CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83643800
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82900050
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82568094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.40785173
2MP0003693_abnormal_embryo_hatching2.98149098
3MP0004859_abnormal_synaptic_plasticity2.90684898
4MP0002653_abnormal_ependyma_morphology2.82548827
5MP0005451_abnormal_body_composition2.81099424
6MP0004270_analgesia2.66790148
7MP0003315_abnormal_perineum_morphology2.46374077
8MP0003635_abnormal_synaptic_transmissio2.43679724
9MP0003646_muscle_fatigue2.37670750
10MP0002734_abnormal_mechanical_nocicepti2.36061235
11MP0002736_abnormal_nociception_after2.32184719
12MP0001968_abnormal_touch/_nociception2.21872893
13MP0004957_abnormal_blastocyst_morpholog2.21423513
14MP0000678_abnormal_parathyroid_gland2.21362226
15MP0005499_abnormal_olfactory_system2.08366459
16MP0005394_taste/olfaction_phenotype2.08366459
17MP0009745_abnormal_behavioral_response2.04222340
18MP0008789_abnormal_olfactory_epithelium2.04113861
19MP0002064_seizures2.03875769
20MP0009697_abnormal_copulation2.03728266
21MP0009046_muscle_twitch1.97380972
22MP0005058_abnormal_lysosome_morphology1.97040023
23MP0005423_abnormal_somatic_nervous1.96037467
24MP0003186_abnormal_redox_activity1.96007132
25MP0003879_abnormal_hair_cell1.88172714
26MP0005501_abnormal_skin_physiology1.86293937
27MP0001905_abnormal_dopamine_level1.86021926
28MP0002822_catalepsy1.83584051
29MP0004185_abnormal_adipocyte_glucose1.78762801
30MP0002572_abnormal_emotion/affect_behav1.78745670
31MP0003786_premature_aging1.78146672
32MP0003718_maternal_effect1.77986218
33MP0002272_abnormal_nervous_system1.77231968
34MP0001529_abnormal_vocalization1.76966784
35MP0002735_abnormal_chemical_nociception1.76712257
36MP0002063_abnormal_learning/memory/cond1.76667465
37MP0000537_abnormal_urethra_morphology1.74867224
38MP0003123_paternal_imprinting1.73399000
39MP0008877_abnormal_DNA_methylation1.73260649
40MP0006292_abnormal_olfactory_placode1.71508331
41MP0000749_muscle_degeneration1.67461085
42MP0005623_abnormal_meninges_morphology1.63719915
43MP0001970_abnormal_pain_threshold1.60815044
44MP0002733_abnormal_thermal_nociception1.57327459
45MP0006276_abnormal_autonomic_nervous1.56694022
46MP0000490_abnormal_crypts_of1.54837695
47MP0000747_muscle_weakness1.54165922
48MP0002837_dystrophic_cardiac_calcinosis1.52438073
49MP0000313_abnormal_cell_death1.52248374
50MP0006036_abnormal_mitochondrial_physio1.50594715
51MP0002877_abnormal_melanocyte_morpholog1.50109190
52MP0004084_abnormal_cardiac_muscle1.48642070
53MP0002080_prenatal_lethality1.48072517
54MP0009840_abnormal_foam_cell1.44146476
55MP0002796_impaired_skin_barrier1.42956190
56MP0001849_ear_inflammation1.41655327
57MP0001440_abnormal_grooming_behavior1.40573022
58MP0004858_abnormal_nervous_system1.39751943
59MP0005330_cardiomyopathy1.38782579
60MP0008932_abnormal_embryonic_tissue1.38677086
61MP0009379_abnormal_foot_pigmentation1.38047631
62MP0000750_abnormal_muscle_regeneration1.37867444
63MP0000751_myopathy1.37300434
64MP0003111_abnormal_nucleus_morphology1.36856428
65MP0002067_abnormal_sensory_capabilities1.34483269
66MP0003077_abnormal_cell_cycle1.32771528
67MP0001486_abnormal_startle_reflex1.32003544
68MP0002638_abnormal_pupillary_reflex1.31567335
69MP0002184_abnormal_innervation1.31195833
70MP0001727_abnormal_embryo_implantation1.30723333
71MP0001984_abnormal_olfaction1.28979435
72MP0003329_amyloid_beta_deposits1.28962345
73MP0009672_abnormal_birth_weight1.27690430
74MP0001764_abnormal_homeostasis1.26758443
75MP0004215_abnormal_myocardial_fiber1.24913221
76MP0000955_abnormal_spinal_cord1.24441533
77MP0006035_abnormal_mitochondrial_morpho1.24096894
78MP0005083_abnormal_biliary_tract1.23001209
79MP0002249_abnormal_larynx_morphology1.22606922
80MP0004133_heterotaxia1.22495021
81MP0001661_extended_life_span1.22314767
82MP0001986_abnormal_taste_sensitivity1.21045728
83MP0005386_behavior/neurological_phenoty1.20933538
84MP0004924_abnormal_behavior1.20933538
85MP0001730_embryonic_growth_arrest1.20872908
86MP0008058_abnormal_DNA_repair1.20757737
87MP0001346_abnormal_lacrimal_gland1.19634973
88MP0001672_abnormal_embryogenesis/_devel1.19434976
89MP0005380_embryogenesis_phenotype1.19434976
90MP0002751_abnormal_autonomic_nervous1.18972922
91MP0004811_abnormal_neuron_physiology1.18841408
92MP0004142_abnormal_muscle_tone1.17965824
93MP0009333_abnormal_splenocyte_physiolog1.17327606
94MP0008007_abnormal_cellular_replicative1.16895841
95MP0000759_abnormal_skeletal_muscle1.15914914
96MP0008872_abnormal_physiological_respon1.15272141
97MP0003705_abnormal_hypodermis_morpholog1.15233109
98MP0005360_urolithiasis1.13852572
99MP0002160_abnormal_reproductive_system1.13164382
100MP0002557_abnormal_social/conspecific_i1.12377485
101MP0008260_abnormal_autophagy1.11085826
102MP0002127_abnormal_cardiovascular_syste1.10928753
103MP0005646_abnormal_pituitary_gland1.09755082
104MP0003984_embryonic_growth_retardation1.07987087
105MP0002019_abnormal_tumor_incidence1.06660591
106MP0002882_abnormal_neuron_morphology1.04864300
107MP0000003_abnormal_adipose_tissue1.03541435
108MP0010094_abnormal_chromosome_stability1.02517636
109MP0000778_abnormal_nervous_system1.00822177
110MP0001485_abnormal_pinna_reflex1.00319338
111MP0002088_abnormal_embryonic_growth/wei1.00125505
112MP0004233_abnormal_muscle_weight0.99897442
113MP0003221_abnormal_cardiomyocyte_apopto0.98897561
114MP0003806_abnormal_nucleotide_metabolis0.98857361
115MP0010030_abnormal_orbit_morphology0.98853476
116MP0004036_abnormal_muscle_relaxation0.98623893
117MP0002269_muscular_atrophy0.97057069
118MP0002085_abnormal_embryonic_tissue0.96222784
119MP0001501_abnormal_sleep_pattern0.95701706
120MP0001881_abnormal_mammary_gland0.93599425
121MP0002066_abnormal_motor_capabilities/c0.93147762
122MP0000534_abnormal_ureter_morphology0.91781036
123MP0002752_abnormal_somatic_nervous0.91590233
124MP0002152_abnormal_brain_morphology0.90041054
125MP0004885_abnormal_endolymph0.85907089
126MP0003122_maternal_imprinting0.85598565
127MP0001963_abnormal_hearing_physiology0.85172805
128MP0003787_abnormal_imprinting0.85107541
129MP0003137_abnormal_impulse_conducting0.85023355
130MP0004087_abnormal_muscle_fiber0.84864055
131MP0002332_abnormal_exercise_endurance0.84652555
132MP0002139_abnormal_hepatobiliary_system0.83993913
133MP0004484_altered_response_of0.82199028
134MP0000681_abnormal_thyroid_gland0.80029140
135MP0002089_abnormal_postnatal_growth/wei0.79111942
136MP0010386_abnormal_urinary_bladder0.79028854
137MP0003861_abnormal_nervous_system0.78771445
138MP0005384_cellular_phenotype0.78119903
139MP0002132_abnormal_respiratory_system0.77902314
140MP0002396_abnormal_hematopoietic_system0.75428085
141MP0001188_hyperpigmentation0.74652953
142MP0004085_abnormal_heartbeat0.74645830
143MP0000762_abnormal_tongue_morphology0.74636088
144MP0008057_abnormal_DNA_replication0.72641697
145MP0010234_abnormal_vibrissa_follicle0.72381698
146MP0003119_abnormal_digestive_system0.72227719
147MP0008875_abnormal_xenobiotic_pharmacok0.71346726
148MP0004145_abnormal_muscle_electrophysio0.71284010
149MP0000350_abnormal_cell_proliferation0.71134350
150MP0009053_abnormal_anal_canal0.70852726
151MP0001697_abnormal_embryo_size0.70780014
152MP0008569_lethality_at_weaning0.70533784
153MP0002229_neurodegeneration0.68936475
154MP0005332_abnormal_amino_acid0.68619574
155MP0005266_abnormal_metabolism0.67831142
156MP0000358_abnormal_cell_content/0.67390918
157MP0000049_abnormal_middle_ear0.67219881
158MP0003942_abnormal_urinary_system0.67160919
159MP0005319_abnormal_enzyme/_coenzyme0.67045533
160MP0002086_abnormal_extraembryonic_tissu0.65738943
161MP0002970_abnormal_white_adipose0.65309641
162MP0000627_abnormal_mammary_gland0.64834349
163MP0005666_abnormal_adipose_tissue0.64697685
164MP0003191_abnormal_cellular_cholesterol0.63045348
165MP0005621_abnormal_cell_physiology0.62092053
166MP0000733_abnormal_muscle_development0.61692925
167MP0004197_abnormal_fetal_growth/weight/0.61594338

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.50012480
2Abnormal mitochondria in muscle tissue (HP:0008316)4.30824770
3Mitochondrial inheritance (HP:0001427)4.04167315
4Myokymia (HP:0002411)4.00258345
5Focal motor seizures (HP:0011153)3.96357776
6Abnormal hair whorl (HP:0010721)3.93339853
7Progressive muscle weakness (HP:0003323)3.91132465
8Ragged-red muscle fibers (HP:0003200)3.83855875
9Hepatocellular necrosis (HP:0001404)3.79640195
10Increased CSF lactate (HP:0002490)3.76090554
11Acute encephalopathy (HP:0006846)3.66314635
12Atonic seizures (HP:0010819)3.61135440
13Progressive macrocephaly (HP:0004481)3.58737374
14Birth length less than 3rd percentile (HP:0003561)3.46971069
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.41823334
16Cerebral hypomyelination (HP:0006808)3.28494846
17Abnormality of glycolysis (HP:0004366)3.20626081
18Increased serum pyruvate (HP:0003542)3.20626081
19Hepatic necrosis (HP:0002605)3.09467378
20Cholecystitis (HP:0001082)3.09364821
21Abnormal gallbladder physiology (HP:0012438)3.09364821
22Myopathic facies (HP:0002058)3.08906570
23Reduced antithrombin III activity (HP:0001976)3.03879167
24Rhabdomyolysis (HP:0003201)3.00735996
25Increased hepatocellular lipid droplets (HP:0006565)2.83778007
26Increased serum lactate (HP:0002151)2.83354958
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81895578
28Epileptic encephalopathy (HP:0200134)2.81825342
29Centrally nucleated skeletal muscle fibers (HP:0003687)2.81658583
30Neuroendocrine neoplasm (HP:0100634)2.78336522
31Pheochromocytoma (HP:0002666)2.77851233
32Exercise-induced myalgia (HP:0003738)2.76729393
33Multiple enchondromatosis (HP:0005701)2.74814403
34Lactic acidosis (HP:0003128)2.72842142
35Emotional lability (HP:0000712)2.72832654
36Reticulocytopenia (HP:0001896)2.72278731
37Unsteady gait (HP:0002317)2.70143663
38Breast hypoplasia (HP:0003187)2.69739158
39Exercise intolerance (HP:0003546)2.67299044
40Testicular atrophy (HP:0000029)2.65938460
41Achilles tendon contracture (HP:0001771)2.65932176
42Microvesicular hepatic steatosis (HP:0001414)2.61066952
43Abnormality of the umbilical cord (HP:0010881)2.58543993
44Trismus (HP:0000211)2.58428298
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56259117
46Respiratory failure (HP:0002878)2.55370634
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53100798
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53100798
49Broad distal phalanx of finger (HP:0009836)2.52782231
50Hypoplasia of the pons (HP:0012110)2.51971591
51Neuroblastoma (HP:0003006)2.50338866
52Primitive neuroectodermal tumor (HP:0030065)2.50338866
53Neuroblastic tumors (HP:0004376)2.50338866
54Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.50338866
55Hypothermia (HP:0002045)2.48614280
56Myoglobinuria (HP:0002913)2.47859392
57Febrile seizures (HP:0002373)2.43347002
58Increased intramyocellular lipid droplets (HP:0012240)2.40107770
59Type I transferrin isoform profile (HP:0003642)2.38392669
60Abnormality of the Achilles tendon (HP:0005109)2.35666185
61Delusions (HP:0000746)2.35365713
62Distal lower limb muscle weakness (HP:0009053)2.35131492
63Abnormality of the pons (HP:0007361)2.35033893
64Abnormality of reticulocytes (HP:0004312)2.34843218
65Poor suck (HP:0002033)2.34422230
66CNS demyelination (HP:0007305)2.31523420
67Abnormality of the fetal cardiovascular system (HP:0010948)2.31412926
68Abnormal umbilical cord blood vessels (HP:0011403)2.31412926
69Single umbilical artery (HP:0001195)2.31412926
70Lipid accumulation in hepatocytes (HP:0006561)2.30196446
71Abnormality of the labia minora (HP:0012880)2.28395135
72Muscle stiffness (HP:0003552)2.28036041
73Vertebral compression fractures (HP:0002953)2.24745316
74CNS hypomyelination (HP:0003429)2.23398435
75Microretrognathia (HP:0000308)2.22397803
76Neoplasm of the peripheral nervous system (HP:0100007)2.21696212
77Abnormality of cells of the erythroid lineage (HP:0012130)2.21440882
78Focal seizures (HP:0007359)2.21242276
79Macrocytic anemia (HP:0001972)2.18548134
80Cerebral edema (HP:0002181)2.18380364
81Optic disc pallor (HP:0000543)2.17787745
82Nemaline bodies (HP:0003798)2.17371251
83Reticulocytosis (HP:0001923)2.17110606
84Muscle fiber inclusion bodies (HP:0100299)2.16989032
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.16398822
86Respiratory difficulties (HP:0002880)2.15794573
87Cholelithiasis (HP:0001081)2.15118437
88Hypokinesia (HP:0002375)2.13922231
89Hyperacusis (HP:0010780)2.13819160
90Absence seizures (HP:0002121)2.13013854
91Short nail (HP:0001799)2.10512582
92Leukodystrophy (HP:0002415)2.07952318
93Myotonia (HP:0002486)2.07863130
94Limb dystonia (HP:0002451)2.06250490
95Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06237366
96Dialeptic seizures (HP:0011146)2.05919875
97Gout (HP:0001997)2.05826885
98Hyperventilation (HP:0002883)2.04989270
99Medial flaring of the eyebrow (HP:0010747)2.01266479
100Renal Fanconi syndrome (HP:0001994)2.00240485
101Exercise-induced muscle cramps (HP:0003710)2.00111464
102Athetosis (HP:0002305)1.99413550
103Hyperammonemia (HP:0001987)1.99291049
104Spastic paraparesis (HP:0002313)1.98641074
105Abnormal number of erythroid precursors (HP:0012131)1.97489649
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97406529
107Abnormal protein N-linked glycosylation (HP:0012347)1.97406529
108Abnormal protein glycosylation (HP:0012346)1.97406529
109Abnormal glycosylation (HP:0012345)1.97406529
110Gait imbalance (HP:0002141)1.97016331
111Colon cancer (HP:0003003)1.95720425
112Generalized amyotrophy (HP:0003700)1.95214191
113Truncus arteriosus (HP:0001660)1.94960604
114Abnormal trabecular bone morphology (HP:0100671)1.94020457
115Aplasia/Hypoplasia of the patella (HP:0006498)1.93752392
116Hypoplastic left heart (HP:0004383)1.91902741
117Abnormality of the tricuspid valve (HP:0001702)1.91240018
118Shoulder girdle muscle weakness (HP:0003547)1.90930976
119Patellar aplasia (HP:0006443)1.90897191
120Postnatal microcephaly (HP:0005484)1.89517221
121Microglossia (HP:0000171)1.88926476
122Self-mutilation (HP:0000742)1.88269173
123Cerebral palsy (HP:0100021)1.87002035
124Abnormality of the distal phalanges of the toes (HP:0010182)1.86941209
125Abnormalities of placenta or umbilical cord (HP:0001194)1.86522963
126Carpal bone hypoplasia (HP:0001498)1.85191066
127Ependymoma (HP:0002888)1.84434716
128Abnormality of the gallbladder (HP:0005264)1.84345104
129Epileptiform EEG discharges (HP:0011182)1.83620979
130Premature ovarian failure (HP:0008209)1.83456191
131Dicarboxylic aciduria (HP:0003215)1.83219511
132Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83219511
133Progressive external ophthalmoplegia (HP:0000590)1.82724871
134Proximal placement of thumb (HP:0009623)1.82138199
135Tongue fasciculations (HP:0001308)1.81984468
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81815558
137Distal lower limb amyotrophy (HP:0008944)1.81215576
138Abnormal gallbladder morphology (HP:0012437)1.80629878
139Opisthotonus (HP:0002179)1.79693731
140Secondary amenorrhea (HP:0000869)1.79105999
141Bulbar palsy (HP:0001283)1.78617982
142Congenital primary aphakia (HP:0007707)1.78440996
143Inability to walk (HP:0002540)1.78349902
144Abnormal number of incisors (HP:0011064)1.78140084
145Increased muscle lipid content (HP:0009058)1.78115224
146Nephrogenic diabetes insipidus (HP:0009806)1.76177415
147EEG with generalized epileptiform discharges (HP:0011198)1.74452450
148Muscle fibrillation (HP:0010546)1.73486725
149Abnormal autonomic nervous system physiology (HP:0012332)1.72480763
150Generalized tonic-clonic seizures (HP:0002069)1.70064419
151Oral leukoplakia (HP:0002745)1.68408042
152Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67554134
153Impaired pain sensation (HP:0007328)1.66142327
154Abnormality of pain sensation (HP:0010832)1.66142327
155Breast aplasia (HP:0100783)1.65294798
156Hypoventilation (HP:0002791)1.64907020
157Hypsarrhythmia (HP:0002521)1.64396972
1583-Methylglutaconic aciduria (HP:0003535)1.64357552
159Visual hallucinations (HP:0002367)1.64204435
160Hypoplastic female external genitalia (HP:0012815)1.63964530
161Degeneration of anterior horn cells (HP:0002398)1.63962525
162Abnormality of the anterior horn cell (HP:0006802)1.63962525
163Pancreatic fibrosis (HP:0100732)1.62499019
164Patent foramen ovale (HP:0001655)1.61846810
165Rough bone trabeculation (HP:0100670)1.61578218
166Selective tooth agenesis (HP:0001592)1.61043867
167Abnormality of the lower motor neuron (HP:0002366)1.60732493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.77214918
2MAP2K73.71570344
3MAP3K43.63896255
4BUB13.57329937
5ARAF3.51691579
6VRK23.39931177
7AKT33.21592943
8SMG12.83742929
9TESK12.77092420
10BRAF2.75869587
11BCKDK2.71513076
12CASK2.56191289
13SCYL22.50367741
14TRIB32.48175660
15IRAK32.41304229
16NEK12.13269831
17STK162.10877483
18CDC72.08394532
19MUSK1.98661763
20CDK191.83202212
21PLK41.79649751
22EPHA41.75906753
23GRK51.75579186
24EIF2AK11.75470522
25WEE11.74355571
26MAP2K41.73056329
27KDR1.70367582
28ERN11.65116776
29MAP3K121.61593275
30NME11.61124512
31PIM21.57141942
32PLK31.54536824
33TAOK21.54474971
34STK38L1.53726646
35PLK21.51248511
36PBK1.46590127
37MARK11.44061160
38MAP3K111.43396141
39DAPK11.37546338
40CDK81.36938920
41LATS21.32693803
42PRPF4B1.31987645
43SIK11.31239794
44MAP3K91.27591173
45PRKCI1.26429691
46CCNB11.23508600
47VRK11.20381068
48MAP3K21.19358245
49CSNK1G31.18471926
50MAP3K81.18212509
51ERBB41.10226708
52NEK21.00953365
53PDK41.00829831
54PDK31.00829831
55AURKA1.00552616
56AURKB1.00254936
57TESK21.00106483
58SRPK10.99622970
59TLK10.98336716
60MAPKAPK30.95880353
61PNCK0.95852282
62MYLK0.95087438
63ABL20.94600499
64DYRK20.94542953
65CSNK1G20.92938998
66EIF2AK30.92046239
67MAP3K10.90959456
68CDK30.90634653
69TTK0.90443918
70MAP3K100.88848890
71CHEK20.88421433
72ILK0.85481837
73CAMKK20.82666850
74NTRK30.81604938
75ATR0.80426563
76MINK10.80400389
77RAF10.80387508
78PLK10.79922780
79CDK40.79456451
80MST1R0.79100880
81STK40.78533994
82PRKCG0.78533300
83PINK10.78062709
84NTRK10.75920859
85PRKD30.72726083
86BRSK10.71762620
87NTRK20.70649243
88CSNK1G10.68605445
89OBSCN0.68088210
90TTN0.67910606
91PAK60.66480932
92STK240.66346272
93AKT20.65068542
94MAPK130.64367985
95SIK20.63277628
96MAPK110.61285450
97TAF10.60683117
98MAP2K30.60086331
99RPS6KA20.60085956
100SGK20.59950392
101TBK10.58093856
102LIMK10.57717827
103CHEK10.57491795
104IRAK20.57068231
105LRRK20.56987837
106KSR20.56199483
107RPS6KA40.55752402
108RPS6KA50.53872674
109CDK180.53163966
110CDK11A0.52054139
111PKN20.52018663
112CDK150.51245673
113DYRK30.50323187
114NME20.49935724
115MTOR0.49249882
116MAP3K30.48319882
117CSNK1A1L0.47981845
118DAPK20.47838202
119EPHA20.47358102
120SGK4940.47044004
121SGK2230.47044004
122CDK140.46709316
123CDK120.46205799
124LMTK20.43526345
125RPS6KB20.43439057
126PRKD20.42567303
127CDK70.42449311
128TAOK10.42351916
129PHKG10.41139807
130PHKG20.41139807
131MAP2K20.41093995
132CAMK2G0.39688308
133SIK30.39594002
134EEF2K0.39380178
135STK380.39029805
136PAK10.38308969
137CDK20.38087157
138ADRBK10.38028496
139CSNK2A10.36941847
140DAPK30.36061754
141PAK40.35180673
142CSNK1E0.34421441
143RPS6KL10.34245811
144RPS6KC10.34245811
145CDK50.32659868
146CSNK2A20.32546993
147CDK90.32131157
148MAP2K10.32087241
149CAMK2A0.31597662
150ICK0.31245327

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.72512567
2RNA polymerase_Homo sapiens_hsa030203.54615253
3Proteasome_Homo sapiens_hsa030503.44241572
4Parkinsons disease_Homo sapiens_hsa050123.29070684
5Synaptic vesicle cycle_Homo sapiens_hsa047212.84756151
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.83311592
7Collecting duct acid secretion_Homo sapiens_hsa049662.62421254
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59035464
9Huntingtons disease_Homo sapiens_hsa050162.56799628
10Alzheimers disease_Homo sapiens_hsa050102.30122104
11Ribosome_Homo sapiens_hsa030102.21486477
12Mismatch repair_Homo sapiens_hsa034302.16313030
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97823921
14Pyrimidine metabolism_Homo sapiens_hsa002401.78858135
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75404885
16Nucleotide excision repair_Homo sapiens_hsa034201.69919835
17Cardiac muscle contraction_Homo sapiens_hsa042601.69674993
18DNA replication_Homo sapiens_hsa030301.66410013
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.66213387
20Fatty acid elongation_Homo sapiens_hsa000621.65968606
21RNA transport_Homo sapiens_hsa030131.64808591
22Basal transcription factors_Homo sapiens_hsa030221.58603083
23Spliceosome_Homo sapiens_hsa030401.55080074
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51208367
25Nicotine addiction_Homo sapiens_hsa050331.51053754
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43763913
27Vibrio cholerae infection_Homo sapiens_hsa051101.43128493
28Galactose metabolism_Homo sapiens_hsa000521.42288016
29Pyruvate metabolism_Homo sapiens_hsa006201.38625141
30Biosynthesis of amino acids_Homo sapiens_hsa012301.34462435
31Purine metabolism_Homo sapiens_hsa002301.34090783
32Vitamin B6 metabolism_Homo sapiens_hsa007501.29389998
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26601571
34Olfactory transduction_Homo sapiens_hsa047401.24937090
35Non-homologous end-joining_Homo sapiens_hsa034501.18908037
36Base excision repair_Homo sapiens_hsa034101.17532998
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17331653
38Carbon metabolism_Homo sapiens_hsa012001.16755486
39Amphetamine addiction_Homo sapiens_hsa050311.11431803
40Homologous recombination_Homo sapiens_hsa034401.07848555
41Regulation of autophagy_Homo sapiens_hsa041401.07439467
42RNA degradation_Homo sapiens_hsa030181.07212855
43Dopaminergic synapse_Homo sapiens_hsa047281.06646462
44Oocyte meiosis_Homo sapiens_hsa041141.05065310
45Cell cycle_Homo sapiens_hsa041101.04530652
46Fructose and mannose metabolism_Homo sapiens_hsa000511.04251552
47Long-term potentiation_Homo sapiens_hsa047201.00427020
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98688503
49GABAergic synapse_Homo sapiens_hsa047270.98500361
50Arginine biosynthesis_Homo sapiens_hsa002200.98388220
51Circadian entrainment_Homo sapiens_hsa047130.96756688
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95409230
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.94972998
54Sulfur relay system_Homo sapiens_hsa041220.94659054
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89889865
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89643240
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89595203
58N-Glycan biosynthesis_Homo sapiens_hsa005100.89502240
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89298664
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88611105
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83231012
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81516962
63Folate biosynthesis_Homo sapiens_hsa007900.80217626
64Taste transduction_Homo sapiens_hsa047420.78838697
65Morphine addiction_Homo sapiens_hsa050320.74935296
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73465448
67Fanconi anemia pathway_Homo sapiens_hsa034600.72337135
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.72333507
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70671979
70Serotonergic synapse_Homo sapiens_hsa047260.67759151
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66284118
72Pentose phosphate pathway_Homo sapiens_hsa000300.64602883
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64560540
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64519629
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64465210
76Cocaine addiction_Homo sapiens_hsa050300.63755194
77Metabolic pathways_Homo sapiens_hsa011000.63277431
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63191660
79Insulin secretion_Homo sapiens_hsa049110.60849256
80Epstein-Barr virus infection_Homo sapiens_hsa051690.58221144
81Systemic lupus erythematosus_Homo sapiens_hsa053220.57810008
82Glutamatergic synapse_Homo sapiens_hsa047240.57504387
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57095346
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57010320
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53183782
86Bladder cancer_Homo sapiens_hsa052190.52613571
87Sulfur metabolism_Homo sapiens_hsa009200.52158693
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.49087374
89Glucagon signaling pathway_Homo sapiens_hsa049220.48719894
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48702491
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47811298
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47182744
93Peroxisome_Homo sapiens_hsa041460.46776089
94Thyroid cancer_Homo sapiens_hsa052160.46704493
95mRNA surveillance pathway_Homo sapiens_hsa030150.46528028
96Other glycan degradation_Homo sapiens_hsa005110.46427522
97Cholinergic synapse_Homo sapiens_hsa047250.44759314
98Calcium signaling pathway_Homo sapiens_hsa040200.44017073
99Colorectal cancer_Homo sapiens_hsa052100.42982912
100Fatty acid metabolism_Homo sapiens_hsa012120.41779912
101Arginine and proline metabolism_Homo sapiens_hsa003300.40238954
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38874018
103Gap junction_Homo sapiens_hsa045400.37697194
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37289156
105Insulin signaling pathway_Homo sapiens_hsa049100.36172757
106Propanoate metabolism_Homo sapiens_hsa006400.35747943
107Phagosome_Homo sapiens_hsa041450.34739353
108Viral carcinogenesis_Homo sapiens_hsa052030.34406587
109Phototransduction_Homo sapiens_hsa047440.33594828
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32907163
111Phenylalanine metabolism_Homo sapiens_hsa003600.32458482
112Alcoholism_Homo sapiens_hsa050340.31745633
113Steroid biosynthesis_Homo sapiens_hsa001000.31496151
114One carbon pool by folate_Homo sapiens_hsa006700.31098103
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31060255
116Glutathione metabolism_Homo sapiens_hsa004800.30489356
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28516466
118Lysine degradation_Homo sapiens_hsa003100.25709413
119Selenocompound metabolism_Homo sapiens_hsa004500.25650465
120Long-term depression_Homo sapiens_hsa047300.25508356
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25446205
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25184537
123Starch and sucrose metabolism_Homo sapiens_hsa005000.24842799
124Fatty acid degradation_Homo sapiens_hsa000710.24679426
125Melanoma_Homo sapiens_hsa052180.24355308
126GnRH signaling pathway_Homo sapiens_hsa049120.24174245
127AMPK signaling pathway_Homo sapiens_hsa041520.23941084
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23436849
129Salivary secretion_Homo sapiens_hsa049700.22589783
130p53 signaling pathway_Homo sapiens_hsa041150.22492541
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21212888
132Apoptosis_Homo sapiens_hsa042100.20090082
133Butanoate metabolism_Homo sapiens_hsa006500.19229370
134HTLV-I infection_Homo sapiens_hsa051660.18835932
135Tyrosine metabolism_Homo sapiens_hsa003500.18703158
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15713656
137Non-small cell lung cancer_Homo sapiens_hsa052230.15157260

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