RLBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal metabolic process (GO:0042574)9.32498963
2retinal rod cell development (GO:0046548)7.90828427
3short-term memory (GO:0007614)7.43061434
4polyketide metabolic process (GO:0030638)7.38112805
5doxorubicin metabolic process (GO:0044598)7.38112805
6daunorubicin metabolic process (GO:0044597)7.38112805
7retinol metabolic process (GO:0042572)7.22351580
8regulation of lipoprotein metabolic process (GO:0050746)7.02690243
9diterpenoid biosynthetic process (GO:0016102)6.97226156
10regulation of apoptotic cell clearance (GO:2000425)6.68339343
11regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)6.60534692
12positive regulation of guanylate cyclase activity (GO:0031284)6.47700613
13regulation of rhodopsin mediated signaling pathway (GO:0022400)6.10950239
14rhodopsin mediated signaling pathway (GO:0016056)6.04757724
15positive regulation of osteoblast proliferation (GO:0033690)6.03489209
16* vitamin A metabolic process (GO:0006776)5.93360450
17regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.90434096
18regulation of guanylate cyclase activity (GO:0031282)5.85759720
19melanin biosynthetic process (GO:0042438)5.81963043
20somite rostral/caudal axis specification (GO:0032525)5.65915608
21photoreceptor cell development (GO:0042461)5.60741735
22regulation of response to osmotic stress (GO:0047484)5.60311818
23melanin metabolic process (GO:0006582)5.35303434
24secondary metabolite biosynthetic process (GO:0044550)5.30766371
25keratan sulfate catabolic process (GO:0042340)5.25712399
26protein-chromophore linkage (GO:0018298)5.22041141
27eye photoreceptor cell development (GO:0042462)5.18702146
28retinal cone cell development (GO:0046549)5.09292408
29* phototransduction (GO:0007602)5.07718703
30negative regulation of heart growth (GO:0061117)5.04091249
31negative regulation of cardiac muscle tissue growth (GO:0055022)5.04091249
32maintenance of protein location in nucleus (GO:0051457)4.95540104
33* phototransduction, visible light (GO:0007603)4.93174805
34righting reflex (GO:0060013)4.87725128
35photoreceptor cell maintenance (GO:0045494)4.85289308
36apoptotic cell clearance (GO:0043277)4.78404762
37terpenoid biosynthetic process (GO:0016114)4.75625278
38cell-cell junction maintenance (GO:0045217)4.69549473
39* detection of light stimulus (GO:0009583)4.67764982
40response to electrical stimulus (GO:0051602)4.65874754
41aminoglycoside antibiotic metabolic process (GO:0030647)4.60694433
42regulation of cilium movement (GO:0003352)4.55823347
43* detection of visible light (GO:0009584)4.48862850
44negative regulation of epidermis development (GO:0045683)4.45123974
45histone H4-K5 acetylation (GO:0043981)4.44168375
46histone H4-K8 acetylation (GO:0043982)4.44168375
47detection of light stimulus involved in sensory perception (GO:0050962)4.35293736
48detection of light stimulus involved in visual perception (GO:0050908)4.35293736
49synaptic vesicle maturation (GO:0016188)4.34863620
50regulation of mammary gland epithelial cell proliferation (GO:0033599)4.28473530
51negative regulation of cardiac muscle hypertrophy (GO:0010614)4.26766312
52notochord development (GO:0030903)4.24253889
53negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.19420868
54negative regulation of telomerase activity (GO:0051974)4.10988702
55negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.07899296
56positive regulation of cGMP biosynthetic process (GO:0030828)4.07529104
57* visual perception (GO:0007601)4.04453516
58modulation by symbiont of host cellular process (GO:0044068)4.02092241
59* sensory perception of light stimulus (GO:0050953)3.99182920
60negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.90504729
61cell junction maintenance (GO:0034331)3.89931572
62primary alcohol metabolic process (GO:0034308)3.88850788
63* retinoid metabolic process (GO:0001523)3.87304485
64response to dietary excess (GO:0002021)3.86998322
65regulation of cGMP metabolic process (GO:0030823)3.85060801
66regulation of telomere maintenance via telomerase (GO:0032210)3.83941341
67regulation of cGMP biosynthetic process (GO:0030826)3.81049146
68chondroitin sulfate catabolic process (GO:0030207)3.80553635
69negative regulation of muscle hypertrophy (GO:0014741)3.78856775
70mitochondrion distribution (GO:0048311)3.71359780
71melanocyte differentiation (GO:0030318)3.70365424
72negative regulation of cell cycle G2/M phase transition (GO:1902750)3.67566823
73regulation of nuclear cell cycle DNA replication (GO:0033262)3.62888496
74* diterpenoid metabolic process (GO:0016101)3.61195462
75* detection of external stimulus (GO:0009581)3.57953574
76glial cell proliferation (GO:0014009)3.57604525
77phenol-containing compound catabolic process (GO:0019336)3.56163113
78muscle organ morphogenesis (GO:0048644)3.56025047
79pigment cell differentiation (GO:0050931)3.55227040
80modified amino acid transport (GO:0072337)3.53031030
81positive regulation of cGMP metabolic process (GO:0030825)3.52812173
82* detection of abiotic stimulus (GO:0009582)3.52233636
83proline transport (GO:0015824)3.52092707
84GMP metabolic process (GO:0046037)3.52024819
85arachidonic acid secretion (GO:0050482)3.49229792
86icosanoid secretion (GO:0032309)3.49229792
87quaternary ammonium group transport (GO:0015697)3.48416794
88adaptation of signaling pathway (GO:0023058)3.47947621
89histone H4-K12 acetylation (GO:0043983)3.41564949
90rRNA transcription (GO:0009303)3.38113851
91negative regulation of catenin import into nucleus (GO:0035414)3.37160924
92primitive streak formation (GO:0090009)3.37084471
93retina development in camera-type eye (GO:0060041)3.35852345
94histone H4-K16 acetylation (GO:0043984)3.35559224
95negative regulation of epidermal cell differentiation (GO:0045605)3.31767432
96negative regulation of cardiac muscle tissue development (GO:0055026)3.31640207
97cellular response to light stimulus (GO:0071482)3.26690309
98regulation of MHC class I biosynthetic process (GO:0045343)3.26435279
99* fat-soluble vitamin metabolic process (GO:0006775)3.24143543
100nonmotile primary cilium assembly (GO:0035058)3.23759097
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23716983
102hormone catabolic process (GO:0042447)3.23203272
103protein localization to kinetochore (GO:0034501)3.21372009
104cellular modified amino acid catabolic process (GO:0042219)3.20837185
105cardiovascular system development (GO:0072358)3.18791953
106thyroid hormone generation (GO:0006590)3.16960875
107ovulation cycle (GO:0042698)3.15074501
108negative regulation of lipid storage (GO:0010888)3.15066718
109sodium-independent organic anion transport (GO:0043252)3.13879363
110photoreceptor cell differentiation (GO:0046530)3.13680425
111eye photoreceptor cell differentiation (GO:0001754)3.13680425
112* terpenoid metabolic process (GO:0006721)3.10019102
113negative regulation of smoothened signaling pathway (GO:0045879)3.09420629
114locomotory exploration behavior (GO:0035641)3.05180674
115nucleoside transmembrane transport (GO:1901642)3.04787813
116ERK1 and ERK2 cascade (GO:0070371)3.02559225
117gamma-aminobutyric acid transport (GO:0015812)3.01455489
118regulation of osteoblast proliferation (GO:0033688)3.01294305
119detection of temperature stimulus (GO:0016048)3.00467388
120coenzyme catabolic process (GO:0009109)2.98277441
121regulation of extracellular matrix disassembly (GO:0010715)2.98216911
122cellular response to cholesterol (GO:0071397)2.97493471
123smooth muscle tissue development (GO:0048745)2.94753006
124cerebral cortex neuron differentiation (GO:0021895)2.94610118
125regulation of hippo signaling (GO:0035330)2.94501439
126microtubule severing (GO:0051013)2.92753325
127phagocytosis, recognition (GO:0006910)2.92227573
128ketone body metabolic process (GO:1902224)2.89996663
129viral entry into host cell (GO:0046718)2.87723779
130regulation of microtubule-based movement (GO:0060632)2.86273919
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.85628767
132face development (GO:0060324)2.84186968
133negative chemotaxis (GO:0050919)2.83715571
134cell fate commitment involved in formation of primary germ layer (GO:0060795)2.83025575
135ventricular system development (GO:0021591)2.81564425
136negative regulation of potassium ion transmembrane transport (GO:1901380)2.79507018
137regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.79142013
138spinal cord development (GO:0021510)2.78337151
139cytidine deamination (GO:0009972)2.77962464
140cytidine metabolic process (GO:0046087)2.77962464
141cytidine catabolic process (GO:0006216)2.77962464
142regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.77320892
143quinone metabolic process (GO:1901661)2.76924229
144regulation of cardiac muscle cell differentiation (GO:2000725)2.76519902
145cellular response to electrical stimulus (GO:0071257)2.76463995
146polyol transport (GO:0015791)2.76460742
147negative regulation of telomere maintenance (GO:0032205)2.76218694
148calcium-mediated signaling using intracellular calcium source (GO:0035584)2.74562777
149regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72966556
150negative regulation of JUN kinase activity (GO:0043508)2.69868390
151branching involved in mammary gland duct morphogenesis (GO:0060444)2.69640197
152regulation of development, heterochronic (GO:0040034)2.68877584
153neurotransmitter-gated ion channel clustering (GO:0072578)2.68307653
154anterior/posterior axis specification (GO:0009948)2.67871849
155myotube differentiation (GO:0014902)2.67214534
156convergent extension (GO:0060026)2.66885084
157melanosome transport (GO:0032402)2.66741610
158regulation of timing of cell differentiation (GO:0048505)2.65142079
159signal transduction involved in regulation of gene expression (GO:0023019)2.63854669
160retinoic acid metabolic process (GO:0042573)2.63847195
161lateral sprouting from an epithelium (GO:0060601)2.62048611
162regulation of microtubule polymerization (GO:0031113)2.54377700
163regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52394960
164zinc ion transmembrane transport (GO:0071577)2.50354352
165cellular component maintenance (GO:0043954)2.49648456
166inositol metabolic process (GO:0006020)2.49083123
167positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.46993713
168regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.46982330
169regulation of macrophage derived foam cell differentiation (GO:0010743)2.46801359
170* isoprenoid metabolic process (GO:0006720)2.45153789
171regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.44481897
172digestive tract morphogenesis (GO:0048546)2.43094554
173cellular response to thyroid hormone stimulus (GO:0097067)2.39023908
174positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.37544541
175positive regulation of extracellular matrix organization (GO:1903055)2.35946673
176negative regulation of organ growth (GO:0046621)2.34176303
177nerve growth factor signaling pathway (GO:0038180)2.33374163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.67654486
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.67654486
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.67654486
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.76884077
5TRIM28_21343339_ChIP-Seq_HEK293_Human4.25964142
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.83418032
7SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.27560365
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.03344888
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.02693521
10GATA1_22025678_ChIP-Seq_K562_Human2.83497898
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.82215865
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.64709530
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.62442691
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47573384
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.47395862
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.47171916
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.43757858
18* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.30573116
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.29665371
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.24613159
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.18207227
22NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.17106866
23ZFP281_18757296_ChIP-ChIP_E14_Mouse2.04533364
24GBX2_23144817_ChIP-Seq_PC3_Human2.00665925
25* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.98313880
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.97644580
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.97630800
28POU5F1_16518401_ChIP-PET_MESCs_Mouse1.94207166
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94081207
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.94048667
31NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.86565721
32TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.86433752
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82067715
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78091178
35RING1B_27294783_Chip-Seq_NPCs_Mouse1.76977404
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.75541705
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75350769
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74396047
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74396047
40E2F1_17053090_ChIP-ChIP_MCF-7_Human1.72846904
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71307506
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70556494
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69649647
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68814049
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67631530
46CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.67342761
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.62986429
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59601250
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56851824
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55314647
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55258172
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54896311
53AHR_22903824_ChIP-Seq_MCF-7_Human1.52897146
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.51506952
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50266277
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50266277
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50053986
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49834779
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48866681
60KDM2B_26808549_Chip-Seq_K562_Human1.47595229
61IRF1_19129219_ChIP-ChIP_H3396_Human1.47189309
62NANOG_18692474_ChIP-Seq_MESCs_Mouse1.47118330
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45081611
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44195538
65POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.43855931
66TBX3_20139965_ChIP-Seq_ESCs_Mouse1.43595500
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42799919
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.42204967
69TBX3_20139965_ChIP-Seq_MESCs_Mouse1.41592563
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41108291
71CJUN_26792858_Chip-Seq_BT549_Human1.40323741
72* TBX20_22080862_ChIP-Seq_HEART_Mouse1.39170993
73* TBX20_22328084_ChIP-Seq_HEART_Mouse1.39170993
74PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.38984304
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.38293467
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37991739
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37941100
78NANOG_18692474_ChIP-Seq_MEFs_Mouse1.36708197
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.36581271
80REST_21632747_ChIP-Seq_MESCs_Mouse1.35241697
81* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33138049
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30844710
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30665294
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30280182
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29164115
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28856982
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.28544510
88RNF2_27304074_Chip-Seq_NSC_Mouse1.28198181
89NANOG_16518401_ChIP-PET_MESCs_Mouse1.26675082
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26227051
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26056770
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.25659607
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25480750
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.25120110
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24699121
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24443911
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.24411712
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.23711058
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23033167
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22928463
101SMAD4_21799915_ChIP-Seq_A2780_Human1.20619035
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.20613684
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.20498688
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20117642
105CLOCK_20551151_ChIP-Seq_293T_Human1.19953047
106IGF1R_20145208_ChIP-Seq_DFB_Human1.18775449
107SOX2_18692474_ChIP-Seq_MESCs_Mouse1.16818110
108POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15597974
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.15076584
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14729067
111SMAD3_21741376_ChIP-Seq_HESCs_Human1.14347312
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13094085
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.10962604
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10182453
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10019664
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09742113
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09685733
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09009567
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08913215
120AR_21572438_ChIP-Seq_LNCaP_Human1.08308973
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07034488
122KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06851056
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04189741
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03198538
125OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02777971
126SMC4_20622854_ChIP-Seq_HELA_Human1.02588296
127* TAL1_26923725_Chip-Seq_HPCs_Mouse1.02586162
128EZH2_27294783_Chip-Seq_ESCs_Mouse1.02502636
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02074506
130FOXA2_19822575_ChIP-Seq_HepG2_Human1.02063470
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01916819
132* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00294391
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99592602
134LXR_22158963_ChIP-Seq_LIVER_Mouse0.99135865
135MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99097237
136STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98708119
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98527241
138SOX3_22085726_ChIP-Seq_NPCs_Mouse0.98326500
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98319799
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.96723411
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95902324
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95866549
143* MITF_21258399_ChIP-Seq_MELANOMA_Human0.95332854
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95232545
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95090976
146SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94889036
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94773506
148RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94441666
149EED_16625203_ChIP-ChIP_MESCs_Mouse0.94384260
150CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94183491
151FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94037373
152SMAD_19615063_ChIP-ChIP_OVARY_Human0.93648384
153TCF4_23295773_ChIP-Seq_U87_Human0.93188906
154PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92479011
155SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91047880
156* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90797891
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90284423
158EZH2_22144423_ChIP-Seq_EOC_Human0.89921070
159EGR1_19032775_ChIP-ChIP_M12_Human0.88233747
160FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88007717
161TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87622848
162Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87328800
163ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87228065
164CBX2_27304074_Chip-Seq_ESCs_Mouse0.86922358
165PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86629404
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86449608
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.86219116
168MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84643126
169WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84617235
170EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83987248
171DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83162039
172SOX2_21211035_ChIP-Seq_LN229_Gbm0.82717469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003011_delayed_dark_adaptation8.52381641
2MP0005551_abnormal_eye_electrophysiolog4.90014003
3MP0001986_abnormal_taste_sensitivity4.50878296
4MP0006292_abnormal_olfactory_placode4.29613701
5* MP0005253_abnormal_eye_physiology3.86706510
6MP0004858_abnormal_nervous_system3.31333302
7MP0006072_abnormal_retinal_apoptosis3.16316951
8MP0005499_abnormal_olfactory_system3.15171465
9MP0005394_taste/olfaction_phenotype3.15171465
10MP0002254_reproductive_system_inflammat2.97783345
11MP0005257_abnormal_intraocular_pressure2.81884786
12MP0002653_abnormal_ependyma_morphology2.73136993
13MP0005377_hearing/vestibular/ear_phenot2.52381598
14MP0003878_abnormal_ear_physiology2.52381598
15MP0001324_abnormal_eye_pigmentation2.50448945
16MP0003300_gastrointestinal_ulcer2.43694689
17* MP0005391_vision/eye_phenotype2.42827474
18MP0003890_abnormal_embryonic-extraembry2.24332101
19* MP0005195_abnormal_posterior_eye2.23266355
20MP0002090_abnormal_vision2.05763845
21MP0008789_abnormal_olfactory_epithelium1.95290985
22MP0000465_gastrointestinal_hemorrhage1.92179631
23MP0002332_abnormal_exercise_endurance1.82916127
24MP0003136_yellow_coat_color1.78615123
25MP0004264_abnormal_extraembryonic_tissu1.76731688
26MP0005075_abnormal_melanosome_morpholog1.71095719
27MP0003183_abnormal_peptide_metabolism1.68536577
28MP0003938_abnormal_ear_development1.61680627
29* MP0002752_abnormal_somatic_nervous1.55667129
30MP0000049_abnormal_middle_ear1.54715857
31MP0003705_abnormal_hypodermis_morpholog1.54646512
32MP0003122_maternal_imprinting1.52371589
33MP0010030_abnormal_orbit_morphology1.45503479
34MP0002877_abnormal_melanocyte_morpholog1.43572391
35MP0002229_neurodegeneration1.42308608
36MP0002233_abnormal_nose_morphology1.41979018
37MP0002127_abnormal_cardiovascular_syste1.41546259
38MP0005408_hypopigmentation1.40853993
39MP0002638_abnormal_pupillary_reflex1.37877806
40MP0002092_abnormal_eye_morphology1.37526036
41MP0004885_abnormal_endolymph1.34979169
42MP0005248_abnormal_Harderian_gland1.34150731
43MP0004270_analgesia1.33796246
44MP0000428_abnormal_craniofacial_morphol1.33414625
45MP0005423_abnormal_somatic_nervous1.32830745
46MP0001486_abnormal_startle_reflex1.31908135
47MP0001293_anophthalmia1.31048035
48MP0000678_abnormal_parathyroid_gland1.28749409
49MP0001984_abnormal_olfaction1.26677529
50MP0000778_abnormal_nervous_system1.21901532
51MP0001879_abnormal_lymphatic_vessel1.19442023
52MP0002102_abnormal_ear_morphology1.15335270
53* MP0002882_abnormal_neuron_morphology1.13900248
54MP0004859_abnormal_synaptic_plasticity1.12708363
55MP0003121_genomic_imprinting1.11354172
56MP0004381_abnormal_hair_follicle1.11010903
57MP0004043_abnormal_pH_regulation1.10029310
58MP0003950_abnormal_plasma_membrane1.08129577
59MP0003755_abnormal_palate_morphology1.06209838
60MP0005197_abnormal_uvea_morphology1.02809017
61MP0003880_abnormal_central_pattern0.98603619
62MP0006035_abnormal_mitochondrial_morpho0.97361822
63MP0003935_abnormal_craniofacial_develop0.96630901
64MP0000631_abnormal_neuroendocrine_gland0.96162285
65MP0010368_abnormal_lymphatic_system0.96047262
66MP0003634_abnormal_glial_cell0.92309518
67MP0001286_abnormal_eye_development0.90873341
68MP0000762_abnormal_tongue_morphology0.89754995
69MP0000371_diluted_coat_color0.87111481
70MP0002116_abnormal_craniofacial_bone0.86491900
71MP0004019_abnormal_vitamin_homeostasis0.86448858
72MP0002932_abnormal_joint_morphology0.84996899
73MP0002751_abnormal_autonomic_nervous0.84760109
74MP0001501_abnormal_sleep_pattern0.83820293
75MP0000372_irregular_coat_pigmentation0.83113038
76MP0002734_abnormal_mechanical_nocicepti0.82377620
77MP0000955_abnormal_spinal_cord0.82060507
78MP0002572_abnormal_emotion/affect_behav0.81829498
79MP0003787_abnormal_imprinting0.81714398
80MP0003861_abnormal_nervous_system0.81395956
81MP0003119_abnormal_digestive_system0.81280787
82MP0005187_abnormal_penis_morphology0.80830238
83MP0002249_abnormal_larynx_morphology0.80693270
84MP0003137_abnormal_impulse_conducting0.80056063
85MP0003635_abnormal_synaptic_transmissio0.78832401
86MP0008961_abnormal_basal_metabolism0.77554071
87MP0002114_abnormal_axial_skeleton0.77017945
88MP0003942_abnormal_urinary_system0.76903602
89MP0000432_abnormal_head_morphology0.76751236
90MP0003690_abnormal_glial_cell0.76277089
91MP0000569_abnormal_digit_pigmentation0.76161908
92MP0001764_abnormal_homeostasis0.76128559
93MP0005174_abnormal_tail_pigmentation0.75565438
94MP0003283_abnormal_digestive_organ0.75497503
95MP0002064_seizures0.74827155
96MP0002095_abnormal_skin_pigmentation0.72544558
97MP0002063_abnormal_learning/memory/cond0.72370031
98MP0001963_abnormal_hearing_physiology0.71329546
99MP0009250_abnormal_appendicular_skeleto0.70803972
100MP0005380_embryogenesis_phenotype0.69658997
101MP0001672_abnormal_embryogenesis/_devel0.69658997
102MP0001849_ear_inflammation0.69486823
103MP0002184_abnormal_innervation0.69398291
104MP0002909_abnormal_adrenal_gland0.67935635
105MP0002697_abnormal_eye_size0.67726310
106MP0005167_abnormal_blood-brain_barrier0.66489509
107MP0000026_abnormal_inner_ear0.65902167
108MP0005275_abnormal_skin_tensile0.65005306
109MP0002088_abnormal_embryonic_growth/wei0.64030622
110MP0008057_abnormal_DNA_replication0.63877017
111MP0003633_abnormal_nervous_system0.62170280
112MP0003984_embryonic_growth_retardation0.62016371
113MP0003879_abnormal_hair_cell0.61648529
114MP0005171_absent_coat_pigmentation0.61464774
115MP0002081_perinatal_lethality0.61102309
116MP0002152_abnormal_brain_morphology0.60831694
117MP0000462_abnormal_digestive_system0.59752808
118MP0001915_intracranial_hemorrhage0.59393988
119MP0000015_abnormal_ear_pigmentation0.59280973
120MP0009046_muscle_twitch0.58262920
121MP0002272_abnormal_nervous_system0.58000405
122MP0002933_joint_inflammation0.57956608
123MP0000920_abnormal_myelination0.57302552
124MP0003937_abnormal_limbs/digits/tail_de0.56206945
125MP0002085_abnormal_embryonic_tissue0.55817982
126MP0003632_abnormal_nervous_system0.54643598
127MP0000647_abnormal_sebaceous_gland0.53450152
128MP0005646_abnormal_pituitary_gland0.53245186
129MP0004233_abnormal_muscle_weight0.49409420
130MP0010352_gastrointestinal_tract_polyps0.48538474
131MP0003329_amyloid_beta_deposits0.48421549
132MP0002938_white_spotting0.48016944
133MP0003631_nervous_system_phenotype0.46444224
134MP0005503_abnormal_tendon_morphology0.46150481
135MP0001502_abnormal_circadian_rhythm0.45523615
136MP0005058_abnormal_lysosome_morphology0.43855569
137MP0004272_abnormal_basement_membrane0.42585105
138MP0005623_abnormal_meninges_morphology0.41869858
139MP0000685_abnormal_immune_system0.40874421
140MP0003303_peritoneal_inflammation0.40096108
141MP0008775_abnormal_heart_ventricle0.39058705
142MP0005193_abnormal_anterior_eye0.38762007
143MP0001485_abnormal_pinna_reflex0.37490539
144* MP0002075_abnormal_coat/hair_pigmentati0.37179997
145MP0005508_abnormal_skeleton_morphology0.36461921
146MP0004084_abnormal_cardiac_muscle0.36224526
147MP0003075_altered_response_to0.29421241
148MP0006138_congestive_heart_failure0.29371654
149MP0005165_increased_susceptibility_to0.28733153
150MP0004036_abnormal_muscle_relaxation0.28398111
151MP0000604_amyloidosis0.27876999
152MP0005386_behavior/neurological_phenoty0.27472299
153MP0004924_abnormal_behavior0.27472299
154MP0003385_abnormal_body_wall0.26840126
155MP0005023_abnormal_wound_healing0.26335614
156MP0002295_abnormal_pulmonary_circulatio0.26049224
157MP0008569_lethality_at_weaning0.24349764
158MP0003724_increased_susceptibility_to0.24022020
159MP0003091_abnormal_cell_migration0.23958792
160MP0010386_abnormal_urinary_bladder0.23485126
161MP0005220_abnormal_exocrine_pancreas0.23257020
162MP0002971_abnormal_brown_adipose0.23203995
163* MP0001186_pigmentation_phenotype0.21119560
164MP0005409_darkened_coat_color0.21084087
165MP0000747_muscle_weakness0.20873989
166MP0004484_altered_response_of0.18035101

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.47797328
2Pendular nystagmus (HP:0012043)6.60947450
3Bony spicule pigmentary retinopathy (HP:0007737)6.26454929
4Abnormal rod and cone electroretinograms (HP:0008323)6.11992070
5Absent rod-and cone-mediated responses on ERG (HP:0007688)6.05136755
6Ulnar claw (HP:0001178)5.59666475
7Bilateral microphthalmos (HP:0007633)5.21240143
8Chorioretinal atrophy (HP:0000533)4.92909632
9Dyschromatopsia (HP:0007641)4.88405875
10Action tremor (HP:0002345)4.87752962
11Attenuation of retinal blood vessels (HP:0007843)4.82413905
12Abolished electroretinogram (ERG) (HP:0000550)4.65112356
13Abnormality of the fovea (HP:0000493)4.63619881
14Aplasia/Hypoplasia of the fovea (HP:0008060)4.63480548
15Hypoplasia of the fovea (HP:0007750)4.63480548
16Protrusio acetabuli (HP:0003179)4.62105247
17Peripheral hypomyelination (HP:0007182)4.61912671
18Termporal pattern (HP:0011008)4.54154230
19Insidious onset (HP:0003587)4.54154230
20Decreased central vision (HP:0007663)4.52235162
21Hepatoblastoma (HP:0002884)4.40656371
22Decreased electroretinogram (ERG) amplitude (HP:0000654)4.36933139
23Segmental peripheral demyelination/remyelination (HP:0003481)4.35244063
24Vertebral compression fractures (HP:0002953)4.34348590
25Pigmentary retinal degeneration (HP:0001146)4.27910348
26Central scotoma (HP:0000603)4.13497261
27Systemic lupus erythematosus (HP:0002725)3.87223150
28Hypochromic microcytic anemia (HP:0004840)3.84734378
29Abnormality of the lower motor neuron (HP:0002366)3.82940632
30Vitreoretinal degeneration (HP:0000655)3.82419842
31Upper limb muscle weakness (HP:0003484)3.80057497
32Abnormal pupillary function (HP:0007686)3.76096319
33Increased corneal curvature (HP:0100692)3.64797155
34Keratoconus (HP:0000563)3.64797155
35* Scotoma (HP:0000575)3.63638767
36Hypopigmentation of the fundus (HP:0007894)3.59573525
37Rib fusion (HP:0000902)3.51929446
38Biconcave vertebral bodies (HP:0004586)3.30603676
39Abnormality of macular pigmentation (HP:0008002)3.27616617
40White forelock (HP:0002211)3.22528169
41Aplasia/Hypoplasia of the macula (HP:0008059)3.22255462
42* Type II diabetes mellitus (HP:0005978)3.10131525
43Posterior subcapsular cataract (HP:0007787)3.01114338
44Aplasia/Hypoplasia affecting the retina (HP:0008061)3.00094685
45Increased CSF protein (HP:0002922)2.99502398
46Constricted visual fields (HP:0001133)2.97896244
47Horizontal nystagmus (HP:0000666)2.95685572
48* Photophobia (HP:0000613)2.93692042
49Ependymoma (HP:0002888)2.92934583
50Hyperventilation (HP:0002883)2.92851437
51Patchy hypopigmentation of hair (HP:0011365)2.84375454
52Beaking of vertebral bodies (HP:0004568)2.78590660
53Complement deficiency (HP:0004431)2.77744838
54Choroideremia (HP:0001139)2.70692552
55Ocular albinism (HP:0001107)2.69202204
56Hypoplasia of the iris (HP:0007676)2.65804493
57Blue irides (HP:0000635)2.64480687
58Postural tremor (HP:0002174)2.63970901
59Impaired proprioception (HP:0010831)2.63576437
60* Macular degeneration (HP:0000608)2.63284645
61Bilateral sensorineural hearing impairment (HP:0008619)2.59405643
62Multiple enchondromatosis (HP:0005701)2.57647539
63Cone-rod dystrophy (HP:0000548)2.56110288
64Abnormality of the astrocytes (HP:0100707)2.54026089
65Astrocytoma (HP:0009592)2.54026089
66Neurofibrillary tangles (HP:0002185)2.52017875
67Progressive sensorineural hearing impairment (HP:0000408)2.46388247
68Abnormality of complement system (HP:0005339)2.43730378
69Iris hypopigmentation (HP:0007730)2.42232024
70Glomerulonephritis (HP:0000099)2.35115502
71Neoplasm of striated muscle (HP:0009728)2.31574692
72Abnormality of the salivary glands (HP:0010286)2.28202762
73Subacute progressive viral hepatitis (HP:0006572)2.23352180
74Bifid tongue (HP:0010297)2.18438075
75Nephroblastoma (Wilms tumor) (HP:0002667)2.17353730
76Aplasia/Hypoplasia of the sternum (HP:0006714)2.16607819
77Partial duplication of thumb phalanx (HP:0009944)2.14173315
78Amyotrophic lateral sclerosis (HP:0007354)2.11332614
79Amyloidosis (HP:0011034)2.11061464
80Embryonal renal neoplasm (HP:0011794)2.09828299
81Rhabdomyosarcoma (HP:0002859)2.09176412
82Abnormality of the pubic bones (HP:0003172)2.09067282
83Hypermetropia (HP:0000540)2.07478052
84Foot dorsiflexor weakness (HP:0009027)2.04480846
85Fused cervical vertebrae (HP:0002949)2.02935216
86Hemiparesis (HP:0001269)2.01921120
87Hyperinsulinemic hypoglycemia (HP:0000825)2.01849550
88Generalized hypotonia (HP:0001290)2.01551901
89Retinitis pigmentosa (HP:0000510)2.00265536
90Epileptic encephalopathy (HP:0200134)1.95940419
91Anomalous pulmonary venous return (HP:0010772)1.95806098
92Rectal fistula (HP:0100590)1.94976222
93Rectovaginal fistula (HP:0000143)1.94976222
94Short humerus (HP:0005792)1.92387641
95Abnormality of chromosome segregation (HP:0002916)1.90423360
96Broad foot (HP:0001769)1.89722314
97Steppage gait (HP:0003376)1.87085512
98Heterochromia iridis (HP:0001100)1.86804400
99Abnormality of the foot musculature (HP:0001436)1.86480220
100Interstitial pulmonary disease (HP:0006530)1.86163987
101Aplasia/hypoplasia of the humerus (HP:0006507)1.85065540
102Severe visual impairment (HP:0001141)1.84888495
103* Wide nasal bridge (HP:0000431)1.84096551
104Intestinal fistula (HP:0100819)1.81467091
105Hammertoe (HP:0001765)1.80604695
106Large earlobe (HP:0009748)1.79223992
107Glioma (HP:0009733)1.78449110
108Ragged-red muscle fibers (HP:0003200)1.77865176
109Amblyopia (HP:0000646)1.75645170
110Partial duplication of the phalanx of hand (HP:0009999)1.75602261
111Febrile seizures (HP:0002373)1.75476847
112Glossoptosis (HP:0000162)1.74200909
113Difficulty running (HP:0009046)1.73626558
114Cerebral inclusion bodies (HP:0100314)1.72998655
115Preauricular skin tag (HP:0000384)1.72964850
116Onion bulb formation (HP:0003383)1.72417096
117Decreased motor nerve conduction velocity (HP:0003431)1.70476226
118Tetraplegia (HP:0002445)1.69336517
119Polar cataract (HP:0010696)1.68318699
120Peripheral demyelination (HP:0011096)1.67531213
121Supranuclear gaze palsy (HP:0000605)1.67291883
122Testicular atrophy (HP:0000029)1.67037561
123Shawl scrotum (HP:0000049)1.66086828
124Thyroiditis (HP:0100646)1.65388172
125Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.64923495
126Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.63867713
127Supernumerary nipples (HP:0002558)1.63431764
128Subcapsular cataract (HP:0000523)1.63092747
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62677537
130Abnormality of the pulmonary veins (HP:0011718)1.61622278
131Megalencephaly (HP:0001355)1.61616227
132Nephritis (HP:0000123)1.60307178
133Vaginal fistula (HP:0004320)1.60003260
134Abnormal lung lobation (HP:0002101)1.58319410
135Neoplasm of the heart (HP:0100544)1.57879973
136Diplopia (HP:0000651)1.56843975
137Abnormality of binocular vision (HP:0011514)1.56843975
138Preauricular pit (HP:0004467)1.56589578
139Periauricular skin pits (HP:0100277)1.56589578
140Generalized hypopigmentation (HP:0007513)1.56401486
141Nasolacrimal duct obstruction (HP:0000579)1.56295065
142Short 5th finger (HP:0009237)1.55941842
143Skin tags (HP:0010609)1.53144754
144Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.52984139
145Aortic aneurysm (HP:0004942)1.52057244
146Gait imbalance (HP:0002141)1.52041086
147Congenital sensorineural hearing impairment (HP:0008527)1.50450755
148Chromosomal breakage induced by crosslinking agents (HP:0003221)1.49577258
149Malignant neoplasm of the central nervous system (HP:0100836)1.49034721
150Abnormality of the phalanges of the hallux (HP:0010057)1.48871571
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.48235528
152Coxa vara (HP:0002812)1.47875522
153Albinism (HP:0001022)1.45542277
154Spondylolisthesis (HP:0003302)1.42414722
155Progressive hearing impairment (HP:0001730)1.40106149
156Absent frontal sinuses (HP:0002688)1.37300588
157Abnormality of the pupil (HP:0000615)1.31520018
158Annular pancreas (HP:0001734)1.29079484
159Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.27302470
160Retinal detachment (HP:0000541)1.27230556
161Stereotypic behavior (HP:0000733)1.26100780
162Epidermoid cyst (HP:0200040)1.21960447
163Premature graying of hair (HP:0002216)1.17984002
164Retinal atrophy (HP:0001105)1.16351978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.40752870
2MST1R5.67929262
3GRK15.42778516
4GRK54.53993910
5GRK63.25906845
6TYRO33.17946868
7MET2.98547323
8ERN12.71274370
9MAPK72.40157198
10ADRBK22.39115054
11EPHA42.38941107
12TRPM72.14949897
13GRK72.11599360
14STK241.95909499
15CASK1.93880658
16TTN1.85633595
17EPHA31.83986474
18NTRK21.79219343
19MARK31.72933934
20CSF1R1.72029471
21NTRK11.69055431
22MATK1.67171121
23PHKG21.63321776
24PHKG11.63321776
25TGFBR21.62545534
26LMTK21.62245744
27TTK1.53073164
28MARK11.42467480
29CAMK41.40771456
30WNK11.38508371
31MAP3K101.38258981
32ADRBK11.37835460
33MOS1.35367756
34SIK21.34598975
35PDGFRA1.34595566
36PRKD31.31608254
37CSNK1A1L1.28671760
38DDR21.27485168
39HIPK21.25810194
40MARK21.22871905
41MAP2K41.20392174
42MYLK1.17649317
43CSNK1G21.12989862
44PAK61.09405610
45AKT31.06724101
46CSNK1G31.05974927
47TGFBR10.98855198
48FGFR30.98678460
49CSNK1G10.97854812
50NTRK30.97508851
51STK100.97040484
52EPHB10.95399179
53PRKG20.95372434
54ABL20.94914686
55CHEK20.94751206
56MAP3K20.89635252
57OBSCN0.87772655
58CDK70.87292514
59CAMK1D0.86025239
60SIK10.85003799
61TEC0.84785681
62DYRK1A0.84459212
63ERBB20.83749646
64MAPK120.83603133
65PINK10.81401175
66UHMK10.78909983
67PRKAA20.76300459
68PRPF4B0.74985110
69PAK30.74835387
70PDGFRB0.74651565
71PRKCZ0.72671613
72CAMK1G0.72108382
73TIE10.71868822
74BTK0.69949508
75PAK40.68289002
76AKT20.67407411
77STK390.64149908
78NEK90.63969260
79STK380.63792479
80JAK10.63319996
81PRKCG0.63058259
82MAP3K90.60923718
83STK30.60633337
84IRAK20.60215876
85CHEK10.58175396
86RIPK10.57497377
87MAP3K70.56850312
88PRKCH0.54766464
89TRIB30.53581502
90STK38L0.53542389
91FGFR20.53267960
92LRRK20.53256375
93PTK2B0.52940339
94PLK10.51361309
95SCYL20.50306110
96MAPKAPK30.49814660
97NEK10.49595090
98SGK2230.48325883
99SGK4940.48325883
100MAPK130.48252357
101SIK30.47915865
102WNK40.47167824
103CDK50.46967929
104LATS20.46776101
105PRKD20.46313692
106MAPK100.44750135
107IGF1R0.44195008
108GSK3A0.43657838
109ALK0.43155785
110NLK0.43045763
111SGK20.42890492
112CDK150.42724996
113PKN10.42472209
114ICK0.42247189
115RPS6KA30.41712947
116DYRK20.41446064
117CDK180.41002575
118MAP3K40.40675850
119GSK3B0.39772991
120PRKACG0.38735186
121FER0.38319655
122EPHB20.38243987
123PRKD10.37750141
124CDK20.37713716
125CDK11A0.37091011
126PRKCB0.37032718
127YES10.36985661
128PDPK10.36387528
129LATS10.36334892
130ROCK20.35628780
131MINK10.35292165
132KSR10.35127720
133CDK10.34239841
134SYK0.33357477
135JAK20.33345130
136PRKCE0.33336802
137MAP3K120.32708194
138BMX0.32601626
139PAK20.32539443
140SGK30.32515633
141CSNK1D0.32430899
142PRKAA10.31898794
143CSNK1E0.31464441
144KSR20.30658066
145PRKCD0.30546980
146EPHA20.30457290
147CDK140.30362408
148PRKCI0.29999880
149MTOR0.29256459
150PRKACA0.28327492
151MAP2K60.28237944
152CSK0.28138601
153PRKACB0.27656497
154MAP3K30.26619265
155BMPR20.26463675
156NEK60.26169345
157SGK10.26162535
158CAMK10.26159932
159MAPK30.25120292
160CAMK2B0.24312247
161CAMK2A0.24108244
162HCK0.23909954

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047449.44947973
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.88917611
3Vitamin B6 metabolism_Homo sapiens_hsa007503.48854740
4Fructose and mannose metabolism_Homo sapiens_hsa000512.45342133
5Tyrosine metabolism_Homo sapiens_hsa003502.44967122
6Nitrogen metabolism_Homo sapiens_hsa009102.28189904
7Phenylalanine metabolism_Homo sapiens_hsa003602.27713407
8Histidine metabolism_Homo sapiens_hsa003402.18192272
9GABAergic synapse_Homo sapiens_hsa047271.91858927
10Glutamatergic synapse_Homo sapiens_hsa047241.81295852
11Complement and coagulation cascades_Homo sapiens_hsa046101.71711732
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65405584
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63938990
14Olfactory transduction_Homo sapiens_hsa047401.59083904
15beta-Alanine metabolism_Homo sapiens_hsa004101.52705513
16ABC transporters_Homo sapiens_hsa020101.47275366
17Retinol metabolism_Homo sapiens_hsa008301.41920371
18Linoleic acid metabolism_Homo sapiens_hsa005911.40596900
19mTOR signaling pathway_Homo sapiens_hsa041501.40209750
20Arachidonic acid metabolism_Homo sapiens_hsa005901.30362045
21Nicotine addiction_Homo sapiens_hsa050331.20067413
22ECM-receptor interaction_Homo sapiens_hsa045121.19857599
23Staphylococcus aureus infection_Homo sapiens_hsa051501.19517552
24Synaptic vesicle cycle_Homo sapiens_hsa047211.18610904
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16701633
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15963827
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15610862
28Galactose metabolism_Homo sapiens_hsa000521.14106323
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13052860
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.08027617
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.07985479
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06187730
33Circadian entrainment_Homo sapiens_hsa047131.04168086
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03668262
35Serotonergic synapse_Homo sapiens_hsa047261.01061087
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97485681
37Lysosome_Homo sapiens_hsa041420.96810364
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94336692
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94059986
40Ether lipid metabolism_Homo sapiens_hsa005650.90901116
41Fatty acid biosynthesis_Homo sapiens_hsa000610.90173750
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89834294
43Mineral absorption_Homo sapiens_hsa049780.89721488
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88967250
45Basal cell carcinoma_Homo sapiens_hsa052170.88547742
46Inositol phosphate metabolism_Homo sapiens_hsa005620.88409067
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.88126887
48Hippo signaling pathway_Homo sapiens_hsa043900.87156872
49Choline metabolism in cancer_Homo sapiens_hsa052310.86987890
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86894682
51Dopaminergic synapse_Homo sapiens_hsa047280.86799227
52mRNA surveillance pathway_Homo sapiens_hsa030150.85059771
53Salivary secretion_Homo sapiens_hsa049700.84104582
54Proteoglycans in cancer_Homo sapiens_hsa052050.84033370
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83307249
56Morphine addiction_Homo sapiens_hsa050320.78242059
57Adherens junction_Homo sapiens_hsa045200.77517629
58Prion diseases_Homo sapiens_hsa050200.77377275
59Melanoma_Homo sapiens_hsa052180.75727865
60Hedgehog signaling pathway_Homo sapiens_hsa043400.73699808
61Focal adhesion_Homo sapiens_hsa045100.73021737
62Tight junction_Homo sapiens_hsa045300.72772704
63GnRH signaling pathway_Homo sapiens_hsa049120.72751595
64Oxytocin signaling pathway_Homo sapiens_hsa049210.72454405
65Long-term potentiation_Homo sapiens_hsa047200.71583070
66cAMP signaling pathway_Homo sapiens_hsa040240.71431349
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.71198378
68Cholinergic synapse_Homo sapiens_hsa047250.70382492
69Glioma_Homo sapiens_hsa052140.70265964
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70196740
71Pertussis_Homo sapiens_hsa051330.70136203
72Wnt signaling pathway_Homo sapiens_hsa043100.67792099
73Taste transduction_Homo sapiens_hsa047420.66992790
74Axon guidance_Homo sapiens_hsa043600.66252459
75Long-term depression_Homo sapiens_hsa047300.65698011
76Malaria_Homo sapiens_hsa051440.63773657
77Rap1 signaling pathway_Homo sapiens_hsa040150.63309615
78Ovarian steroidogenesis_Homo sapiens_hsa049130.62573133
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62074451
80Calcium signaling pathway_Homo sapiens_hsa040200.61953768
81MicroRNAs in cancer_Homo sapiens_hsa052060.61772333
82Gastric acid secretion_Homo sapiens_hsa049710.61020034
83Melanogenesis_Homo sapiens_hsa049160.60858504
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60616792
85Renin secretion_Homo sapiens_hsa049240.59905304
86Small cell lung cancer_Homo sapiens_hsa052220.59896593
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.59741029
88Dilated cardiomyopathy_Homo sapiens_hsa054140.58195721
89Renal cell carcinoma_Homo sapiens_hsa052110.55271189
90Ras signaling pathway_Homo sapiens_hsa040140.54598231
91Insulin secretion_Homo sapiens_hsa049110.54247989
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53393912
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.53202573
94Notch signaling pathway_Homo sapiens_hsa043300.52903190
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50800293
96Non-small cell lung cancer_Homo sapiens_hsa052230.49688465
97Bile secretion_Homo sapiens_hsa049760.49357185
98Vibrio cholerae infection_Homo sapiens_hsa051100.49082687
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47466675
100Phagosome_Homo sapiens_hsa041450.45050294
101Gap junction_Homo sapiens_hsa045400.44268665
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44072865
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44044813
104Pancreatic secretion_Homo sapiens_hsa049720.43500235
105Pathways in cancer_Homo sapiens_hsa052000.43197951
106Biosynthesis of amino acids_Homo sapiens_hsa012300.42856382
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42748188
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42668853
109ErbB signaling pathway_Homo sapiens_hsa040120.40767907
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40631929
111Dorso-ventral axis formation_Homo sapiens_hsa043200.40096323
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39354278
113Colorectal cancer_Homo sapiens_hsa052100.38226609
114Amphetamine addiction_Homo sapiens_hsa050310.37544391
115Collecting duct acid secretion_Homo sapiens_hsa049660.37287573
116Thyroid hormone synthesis_Homo sapiens_hsa049180.36827519
117Circadian rhythm_Homo sapiens_hsa047100.35939929
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35715935
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35597752
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35597471
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35174475
122Cocaine addiction_Homo sapiens_hsa050300.35170374
123Other glycan degradation_Homo sapiens_hsa005110.34806822
124TGF-beta signaling pathway_Homo sapiens_hsa043500.34634054
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33453393
126Endometrial cancer_Homo sapiens_hsa052130.33248527
127VEGF signaling pathway_Homo sapiens_hsa043700.33014521
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.32661699
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32513355
130MAPK signaling pathway_Homo sapiens_hsa040100.32338282
131African trypanosomiasis_Homo sapiens_hsa051430.32113743
132PPAR signaling pathway_Homo sapiens_hsa033200.30948932
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30851278
134FoxO signaling pathway_Homo sapiens_hsa040680.30742850
135AMPK signaling pathway_Homo sapiens_hsa041520.30629854
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.30551945
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30475079
138Fatty acid elongation_Homo sapiens_hsa000620.29795148
139Endocytosis_Homo sapiens_hsa041440.29147578
140Arginine biosynthesis_Homo sapiens_hsa002200.28621328
141Fatty acid metabolism_Homo sapiens_hsa012120.25169676
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.23745776

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