RLF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.33520613
2nuclear pore organization (GO:0006999)5.98048499
3pre-miRNA processing (GO:0031054)5.25647759
4mitotic sister chromatid cohesion (GO:0007064)4.85005310
5regulation of RNA export from nucleus (GO:0046831)4.71680970
6pore complex assembly (GO:0046931)4.68939174
7histone H3-K4 trimethylation (GO:0080182)4.47704521
8peptidyl-lysine trimethylation (GO:0018023)4.40616059
9establishment of protein localization to Golgi (GO:0072600)4.34308898
10negative regulation of histone methylation (GO:0031061)4.29652994
11protein targeting to Golgi (GO:0000042)4.26101981
12histone H2A monoubiquitination (GO:0035518)4.17534989
13retrograde transport, vesicle recycling within Golgi (GO:0000301)4.03600260
14mitotic chromosome condensation (GO:0007076)4.02323377
15protein localization to kinetochore (GO:0034501)4.01372731
16regulation of histone H3-K9 methylation (GO:0051570)3.97862231
17protein K11-linked deubiquitination (GO:0035871)3.97093961
18dosage compensation (GO:0007549)3.77914855
19regulation of nucleobase-containing compound transport (GO:0032239)3.75477167
20regulation of sister chromatid cohesion (GO:0007063)3.73940839
21histone H3-K9 modification (GO:0061647)3.73412528
22centriole replication (GO:0007099)3.73046484
23microtubule anchoring (GO:0034453)3.69898083
24heterochromatin organization (GO:0070828)3.69524184
25positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.69345994
26positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.69345994
27positive regulation of mitotic sister chromatid separation (GO:1901970)3.69345994
28acrosome assembly (GO:0001675)3.65804183
29regulation of telomere maintenance via telomerase (GO:0032210)3.59874657
30negative regulation of DNA repair (GO:0045738)3.54465178
31DNA replication-dependent nucleosome organization (GO:0034723)3.54241410
32DNA replication-dependent nucleosome assembly (GO:0006335)3.54241410
33mitotic nuclear envelope disassembly (GO:0007077)3.52260097
34regulation of spindle organization (GO:0090224)3.50443747
35DNA unwinding involved in DNA replication (GO:0006268)3.50010447
36mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.49174155
37positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.49174155
38peptidyl-lysine methylation (GO:0018022)3.48522906
39sister chromatid segregation (GO:0000819)3.47988938
40chromatin assembly (GO:0031497)3.47000851
41NLS-bearing protein import into nucleus (GO:0006607)3.46564152
42negative regulation of neurotransmitter secretion (GO:0046929)3.44177982
43nuclear envelope disassembly (GO:0051081)3.43916614
44membrane disassembly (GO:0030397)3.43916614
45regulation of posttranscriptional gene silencing (GO:0060147)3.42264498
46regulation of gene silencing by miRNA (GO:0060964)3.42264498
47regulation of gene silencing by RNA (GO:0060966)3.42264498
48histone H3-K9 demethylation (GO:0033169)3.40221059
49histone lysine methylation (GO:0034968)3.39541166
50protein localization to chromosome, centromeric region (GO:0071459)3.39358489
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38358352
52DNA duplex unwinding (GO:0032508)3.36738815
53DNA geometric change (GO:0032392)3.35894682
54histone H3-K36 demethylation (GO:0070544)3.33251786
55regulation of mitotic spindle organization (GO:0060236)3.30180560
56positive regulation of chromosome segregation (GO:0051984)3.25794804
57cytoplasmic mRNA processing body assembly (GO:0033962)3.25629272
58neural tube formation (GO:0001841)3.25070007
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23289922
60microtubule depolymerization (GO:0007019)3.15951345
61RNA stabilization (GO:0043489)3.15412007
62mRNA stabilization (GO:0048255)3.15412007
63phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.12828396
64protein K48-linked deubiquitination (GO:0071108)3.12143921
65monoubiquitinated protein deubiquitination (GO:0035520)3.12095747
66regulation of centriole replication (GO:0046599)3.09321260
67regulation of DNA endoreduplication (GO:0032875)3.08982130
68paraxial mesoderm development (GO:0048339)3.08451193
69histone lysine demethylation (GO:0070076)3.08098147
70protein localization to chromosome (GO:0034502)3.06332751
71regulation of protein polyubiquitination (GO:1902914)3.06073118
72histone H3-K4 methylation (GO:0051568)3.05104721
73histone demethylation (GO:0016577)3.02904989
74negative regulation of histone modification (GO:0031057)3.01447379
75protein localization to Golgi apparatus (GO:0034067)2.99284823
76mitotic metaphase plate congression (GO:0007080)2.97859846
77pyrimidine dimer repair (GO:0006290)2.97338097
78nucleus organization (GO:0006997)2.94630313
79spindle assembly involved in mitosis (GO:0090307)2.94547283
80negative regulation of chromatin modification (GO:1903309)2.93801558
81intra-Golgi vesicle-mediated transport (GO:0006891)2.92187545
82mitotic sister chromatid segregation (GO:0000070)2.91227980
83metaphase plate congression (GO:0051310)2.89784328
84positive regulation of developmental pigmentation (GO:0048087)2.88193272
85negative regulation of DNA recombination (GO:0045910)2.86796364
86peptidyl-threonine dephosphorylation (GO:0035970)2.86709704
87histone H4-K12 acetylation (GO:0043983)2.86602295
88positive regulation of SMAD protein import into nucleus (GO:0060391)2.84630984
89microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.84051543
90Golgi to endosome transport (GO:0006895)2.83983423
91attachment of spindle microtubules to kinetochore (GO:0008608)2.83956149
92sister chromatid cohesion (GO:0007062)2.83222074
93N-terminal protein amino acid acetylation (GO:0006474)2.83140746
94histone H3-K9 methylation (GO:0051567)2.82724839
95translesion synthesis (GO:0019985)2.82192170
96stress granule assembly (GO:0034063)2.81923663
97protein deubiquitination (GO:0016579)2.80487572
98nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.79995598
99gene silencing by RNA (GO:0031047)2.79713418
100protein K6-linked ubiquitination (GO:0085020)2.79435132
101hippo signaling (GO:0035329)2.78381850
102chromatin assembly or disassembly (GO:0006333)2.78168603
103nuclear envelope organization (GO:0006998)2.77848093
104regulation of chromatin silencing (GO:0031935)2.75654825
105histone H2A ubiquitination (GO:0033522)2.73656292
106positive regulation of mRNA processing (GO:0050685)2.73360968
107regulation of centrosome cycle (GO:0046605)2.72552596
108interkinetic nuclear migration (GO:0022027)2.71193593
109protein dealkylation (GO:0008214)2.70443384
110protein demethylation (GO:0006482)2.70443384
111regulation of chromosome segregation (GO:0051983)2.70381791
112negative regulation of translation, ncRNA-mediated (GO:0040033)2.68788886
113regulation of translation, ncRNA-mediated (GO:0045974)2.68788886
114negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68788886
115response to UV-C (GO:0010225)2.67793995
116peptidyl-lysine dimethylation (GO:0018027)2.67641365
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.67306087
118DNA conformation change (GO:0071103)2.66657190
119regulation of histone H3-K27 methylation (GO:0061085)2.66647048
120regulation of DNA methylation (GO:0044030)2.66298812
121regulation of centrosome duplication (GO:0010824)2.65702690
122spermatid nucleus differentiation (GO:0007289)2.64897631
123protein K63-linked deubiquitination (GO:0070536)2.63969006
124regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.63931212
125positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.63931212
126regulation of gene silencing (GO:0060968)2.63041048
127glucocorticoid receptor signaling pathway (GO:0042921)2.62370545
128DNA replication checkpoint (GO:0000076)2.62363908
129regulation of translational termination (GO:0006449)2.62337921
130histone H4-K5 acetylation (GO:0043981)2.61833988
131histone H4-K8 acetylation (GO:0043982)2.61833988
132positive regulation of DNA-templated transcription, initiation (GO:2000144)2.61705146
133spindle assembly (GO:0051225)2.59200129
134meiotic chromosome segregation (GO:0045132)2.58715388
135regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.58602514
136regulation of helicase activity (GO:0051095)2.58387065
137embryonic process involved in female pregnancy (GO:0060136)2.58229715
138spindle checkpoint (GO:0031577)2.57972157
139protein modification by small protein removal (GO:0070646)2.56699112
140histone mRNA catabolic process (GO:0071044)2.56140645
141negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.55619461
142kinetochore organization (GO:0051383)2.54687148
143histone H2A acetylation (GO:0043968)2.54283099
144non-recombinational repair (GO:0000726)2.54241159
145double-strand break repair via nonhomologous end joining (GO:0006303)2.54241159
146histone methylation (GO:0016571)2.53426478
147histone H4-K16 acetylation (GO:0043984)2.53383141
148positive regulation of mRNA metabolic process (GO:1903313)2.53127434
149regulation of histone methylation (GO:0031060)2.52326299
150protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.52308332
151determination of adult lifespan (GO:0008340)2.51581538
152response to lipoprotein particle (GO:0055094)2.51249632
153regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.51019364
154androgen receptor signaling pathway (GO:0030521)2.50697304
155positive regulation of mRNA 3-end processing (GO:0031442)2.49528820
156centrosome duplication (GO:0051298)2.48513726
157positive regulation of histone methylation (GO:0031062)2.46309066
158regulation of mRNA splicing, via spliceosome (GO:0048024)2.46255379
159coronary vasculature morphogenesis (GO:0060977)2.46221512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.90209283
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.90480749
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85790255
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.61703458
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.40158548
6* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37700197
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27766477
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.93926585
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.86822997
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61842804
11IGF1R_20145208_ChIP-Seq_DFB_Human2.52302426
12MYC_22102868_ChIP-Seq_BL_Human2.38830921
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.35474285
14FUS_26573619_Chip-Seq_HEK293_Human2.30975332
15TAF15_26573619_Chip-Seq_HEK293_Human2.30747319
16ZNF274_21170338_ChIP-Seq_K562_Hela2.25943368
17GBX2_23144817_ChIP-Seq_PC3_Human2.25235423
18EWS_26573619_Chip-Seq_HEK293_Human2.16370802
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.14786902
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.14720739
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10945218
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.05617612
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.05617612
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.05617612
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04035882
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00237849
27E2F7_22180533_ChIP-Seq_HELA_Human10.0171662
28AR_21909140_ChIP-Seq_LNCAP_Human1.99821097
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.96121553
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.92249006
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91857986
32P300_19829295_ChIP-Seq_ESCs_Human1.76456982
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73224790
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.72746108
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68725774
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67810662
37EZH2_22144423_ChIP-Seq_EOC_Human1.66281091
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65986119
39* STAT3_23295773_ChIP-Seq_U87_Human1.65570311
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65253956
41SMAD4_21799915_ChIP-Seq_A2780_Human1.64404712
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61154444
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.60671332
44* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59940491
45ER_23166858_ChIP-Seq_MCF-7_Human1.59902673
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58395884
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57711930
48CBP_20019798_ChIP-Seq_JUKART_Human1.56570794
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56570794
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55148040
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.54181007
52TCF7_22412390_ChIP-Seq_EML_Mouse1.50172235
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50090445
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49335437
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48842193
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48404301
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47478052
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47263434
59SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.46672229
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.46057467
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45415703
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44827692
63* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.44538390
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44350385
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44333968
66* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43633813
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42975230
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41864912
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41469590
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41454523
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41454523
72* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41186928
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41049529
74TCF4_23295773_ChIP-Seq_U87_Human1.39788692
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38520213
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38109637
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36933274
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36086268
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.35121824
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35053013
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34458910
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.33172202
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31888320
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28204832
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27005794
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.26001186
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24635686
88KDM2B_26808549_Chip-Seq_DND41_Human1.23379563
89* E2F1_18555785_Chip-Seq_ESCs_Mouse1.22479832
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.22406750
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22159536
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21908407
93* KDM5A_27292631_Chip-Seq_BREAST_Human1.20709226
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20437483
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.18972948
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18934036
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18123515
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18051899
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17149190
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16035101
101AR_25329375_ChIP-Seq_VCAP_Human1.15980045
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15244096
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15161410
104IRF1_19129219_ChIP-ChIP_H3396_Human1.14877042
105* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14525160
106NANOG_21062744_ChIP-ChIP_HESCs_Human1.14211637
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14051897
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13837710
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13341658
110CIITA_25753668_ChIP-Seq_RAJI_Human1.13209204
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12953245
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12861180
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12603853
114TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12566471
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12326902
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11988558
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11120972
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10889162
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10668677
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09567222
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08705028
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08487739
123* CHD1_26751641_Chip-Seq_LNCaP_Human1.08384827
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08024668
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.07579581
126GATA1_22025678_ChIP-Seq_K562_Human1.07241795
127VDR_22108803_ChIP-Seq_LS180_Human1.06467008
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06243903
129PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06219594
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06135911
131CMYC_18555785_Chip-Seq_ESCs_Mouse1.05650533
132RUNX2_22187159_ChIP-Seq_PCA_Human1.04885768
133* TBL1_22424771_ChIP-Seq_293T_Human1.04535740
134TP53_16413492_ChIP-PET_HCT116_Human1.04508243
135FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03748382
136PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03635830
137TCF4_18268006_ChIP-ChIP_LS174T_Human1.03462980
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03323561
139MYB_26560356_Chip-Seq_TH1_Human1.02477818
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02075163
141STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01854150
142SOX9_26525672_Chip-Seq_HEART_Mouse1.01732664
143* VDR_23849224_ChIP-Seq_CD4+_Human1.00294460
144UTX_26944678_Chip-Seq_JUKART_Human0.99995950
145* BRD4_25478319_ChIP-Seq_HGPS_Human0.99892440
146POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99827180
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99293920
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.99176410
149* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98938312
150P53_22387025_ChIP-Seq_ESCs_Mouse0.97635953
151CLOCK_20551151_ChIP-Seq_293T_Human0.97391603
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97360735
153OCT4_18555785_Chip-Seq_ESCs_Mouse0.96650852
154AR_21572438_ChIP-Seq_LNCaP_Human0.95412397
155PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94651129
156STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94576315
157BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93530579
158* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93524128
159CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92655253
160TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92621926
161DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92112513
162VDR_21846776_ChIP-Seq_THP-1_Human0.91313395
163TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90507486
164P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89666768
165ELK1_19687146_ChIP-ChIP_HELA_Human0.89498224
166NCOR1_26117541_ChIP-Seq_K562_Human0.89325908
167* MAF_26560356_Chip-Seq_TH1_Human0.89051819
168* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88793769
169* TFEB_21752829_ChIP-Seq_HELA_Human0.88422791
170FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86787476
171* KDM2B_26808549_Chip-Seq_JURKAT_Human0.86634229
172MYB_26560356_Chip-Seq_TH2_Human0.86171081
173ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85392629
174SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83087647
175POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82576429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.65239719
2MP0008057_abnormal_DNA_replication3.25787778
3MP0010094_abnormal_chromosome_stability3.25263196
4MP0005076_abnormal_cell_differentiation3.11107894
5MP0008995_early_reproductive_senescence2.91390691
6MP0010307_abnormal_tumor_latency2.87492848
7MP0003111_abnormal_nucleus_morphology2.82317819
8MP0003705_abnormal_hypodermis_morpholog2.72344399
9MP0003077_abnormal_cell_cycle2.69791317
10MP0000569_abnormal_digit_pigmentation2.44449066
11MP0003693_abnormal_embryo_hatching2.39207562
12MP0004957_abnormal_blastocyst_morpholog2.35176927
13MP0003890_abnormal_embryonic-extraembry2.22841776
14MP0003221_abnormal_cardiomyocyte_apopto2.16832280
15MP0000350_abnormal_cell_proliferation2.15162000
16MP0008877_abnormal_DNA_methylation2.08793264
17MP0001730_embryonic_growth_arrest2.03723229
18MP0003123_paternal_imprinting2.00681902
19MP0010234_abnormal_vibrissa_follicle1.99390095
20MP0008007_abnormal_cellular_replicative1.99190230
21MP0004197_abnormal_fetal_growth/weight/1.92447588
22MP0002084_abnormal_developmental_patter1.86428841
23MP0003656_abnormal_erythrocyte_physiolo1.85879493
24MP0001672_abnormal_embryogenesis/_devel1.85589727
25MP0005380_embryogenesis_phenotype1.85589727
26MP0003121_genomic_imprinting1.83158567
27MP0002086_abnormal_extraembryonic_tissu1.82791984
28MP0002088_abnormal_embryonic_growth/wei1.75151703
29MP0003984_embryonic_growth_retardation1.74794354
30MP0008058_abnormal_DNA_repair1.74638649
31MP0003300_gastrointestinal_ulcer1.65798228
32MP0002085_abnormal_embryonic_tissue1.65235967
33MP0003122_maternal_imprinting1.63583502
34MP0000427_abnormal_hair_cycle1.61430811
35MP0001697_abnormal_embryo_size1.61032458
36MP0001929_abnormal_gametogenesis1.55090473
37MP0003787_abnormal_imprinting1.52404236
38MP0000778_abnormal_nervous_system1.52104601
39MP0003566_abnormal_cell_adhesion1.52053922
40MP0001293_anophthalmia1.51969896
41MP0000733_abnormal_muscle_development1.49624790
42MP0000647_abnormal_sebaceous_gland1.47222447
43MP0003303_peritoneal_inflammation1.46903348
44MP0004808_abnormal_hematopoietic_stem1.44226788
45MP0003567_abnormal_fetal_cardiomyocyte1.43558401
46MP0002877_abnormal_melanocyte_morpholog1.42748242
47MP0003950_abnormal_plasma_membrane1.42671121
48MP0002396_abnormal_hematopoietic_system1.41425277
49MP0002638_abnormal_pupillary_reflex1.40816263
50MP0009053_abnormal_anal_canal1.39318398
51MP0006292_abnormal_olfactory_placode1.38361892
52MP0003937_abnormal_limbs/digits/tail_de1.35046401
53MP0002080_prenatal_lethality1.33240937
54MP0005023_abnormal_wound_healing1.33120211
55MP0000537_abnormal_urethra_morphology1.33086165
56MP0005248_abnormal_Harderian_gland1.28449272
57MP0003091_abnormal_cell_migration1.25461387
58MP0009703_decreased_birth_body1.25065600
59MP0001849_ear_inflammation1.24338004
60MP0003941_abnormal_skin_development1.23442425
61MP0005645_abnormal_hypothalamus_physiol1.22849227
62MP0005623_abnormal_meninges_morphology1.20920649
63MP0003315_abnormal_perineum_morphology1.20604908
64MP0000428_abnormal_craniofacial_morphol1.19838639
65MP0002009_preneoplasia1.18932701
66MP0001299_abnormal_eye_distance/1.18881782
67MP0002925_abnormal_cardiovascular_devel1.17680136
68MP0008932_abnormal_embryonic_tissue1.15869282
69MP0002090_abnormal_vision1.15832302
70MP0002092_abnormal_eye_morphology1.14998020
71MP0003119_abnormal_digestive_system1.14994989
72MP0005187_abnormal_penis_morphology1.13680125
73MP0003698_abnormal_male_reproductive1.11537390
74MP0003115_abnormal_respiratory_system1.10113769
75MP0002102_abnormal_ear_morphology1.09086787
76MP0002166_altered_tumor_susceptibility1.08200799
77MP0003718_maternal_effect1.06815503
78MP0004264_abnormal_extraembryonic_tissu1.05545240
79MP0010678_abnormal_skin_adnexa1.04361846
80MP0002697_abnormal_eye_size1.04001467
81MP0003935_abnormal_craniofacial_develop1.03839344
82MP0001915_intracranial_hemorrhage1.03487190
83MP0002233_abnormal_nose_morphology1.02836279
84MP0009672_abnormal_birth_weight1.00503260
85MP0000432_abnormal_head_morphology1.00131192
86MP0001502_abnormal_circadian_rhythm0.99657335
87MP0000653_abnormal_sex_gland0.98814406
88MP0008438_abnormal_cutaneous_collagen0.97994119
89MP0009046_muscle_twitch0.95935833
90MP0000703_abnormal_thymus_morphology0.95294387
91MP0005394_taste/olfaction_phenotype0.94952621
92MP0005499_abnormal_olfactory_system0.94952621
93MP0006054_spinal_hemorrhage0.94305006
94MP0002019_abnormal_tumor_incidence0.93961379
95MP0005367_renal/urinary_system_phenotyp0.93548464
96MP0000516_abnormal_urinary_system0.93548464
97MP0005621_abnormal_cell_physiology0.93172896
98MP0005391_vision/eye_phenotype0.92360739
99MP0000490_abnormal_crypts_of0.92170334
100MP0009278_abnormal_bone_marrow0.91592822
101MP0000313_abnormal_cell_death0.89211680
102MP0010030_abnormal_orbit_morphology0.88180294
103MP0002006_tumorigenesis0.87726618
104MP0001177_atelectasis0.87535111
105MP0001919_abnormal_reproductive_system0.87512301
106MP0003448_altered_tumor_morphology0.87169460
107MP0006276_abnormal_autonomic_nervous0.87024669
108MP0003786_premature_aging0.85375823
109MP0000383_abnormal_hair_follicle0.83343241
110MP0008789_abnormal_olfactory_epithelium0.82590708
111MP0004185_abnormal_adipocyte_glucose0.82345238
112MP0009115_abnormal_fat_cell0.81011580
113MP0000371_diluted_coat_color0.80404164
114MP0005253_abnormal_eye_physiology0.80079142
115MP0001286_abnormal_eye_development0.79438286
116MP0002751_abnormal_autonomic_nervous0.79434686
117MP0003699_abnormal_female_reproductive0.78215371
118MP0005384_cellular_phenotype0.77965678
119MP0002210_abnormal_sex_determination0.77541324
120MP0000631_abnormal_neuroendocrine_gland0.77174559
121MP0001984_abnormal_olfaction0.76227086
122MP0008770_decreased_survivor_rate0.76196801
123MP0002234_abnormal_pharynx_morphology0.75572134
124MP0001119_abnormal_female_reproductive0.75207476
125MP0003453_abnormal_keratinocyte_physiol0.74854668
126MP0003861_abnormal_nervous_system0.73992338
127MP0005397_hematopoietic_system_phenotyp0.73979431
128MP0001545_abnormal_hematopoietic_system0.73979431
129MP0001145_abnormal_male_reproductive0.73950785
130MP0003283_abnormal_digestive_organ0.73312599
131MP0000627_abnormal_mammary_gland0.72755480
132MP0002098_abnormal_vibrissa_morphology0.72109731
133MP0005503_abnormal_tendon_morphology0.70998062
134MP0000266_abnormal_heart_morphology0.70765659
135MP0002161_abnormal_fertility/fecundity0.70618431
136MP0003385_abnormal_body_wall0.70562234
137MP0000015_abnormal_ear_pigmentation0.69554209
138MP0005647_abnormal_sex_gland0.69538233
139MP0002111_abnormal_tail_morphology0.69098847
140MP0003763_abnormal_thymus_physiology0.68258535
141MP0003755_abnormal_palate_morphology0.68211708
142MP0001784_abnormal_fluid_regulation0.68158759
143MP0002081_perinatal_lethality0.67365508
144MP0003880_abnormal_central_pattern0.67083679
145MP0002398_abnormal_bone_marrow0.67080635
146MP0003943_abnormal_hepatobiliary_system0.66567845
147MP0000955_abnormal_spinal_cord0.66544568

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.52954205
2Chronic hepatic failure (HP:0100626)3.50005977
3Abnormality of the astrocytes (HP:0100707)3.37885743
4Astrocytoma (HP:0009592)3.37885743
5Medulloblastoma (HP:0002885)3.28048015
6Tubulointerstitial nephritis (HP:0001970)3.14631240
7Volvulus (HP:0002580)3.07839137
8Short 4th metacarpal (HP:0010044)3.03990333
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.03990333
10Acute myeloid leukemia (HP:0004808)3.03235364
11Colon cancer (HP:0003003)2.90428384
12Chromsome breakage (HP:0040012)2.86265304
13Glioma (HP:0009733)2.86002774
14Subacute progressive viral hepatitis (HP:0006572)2.83235503
15Gonadotropin excess (HP:0000837)2.78341199
16Thyroid carcinoma (HP:0002890)2.77082322
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.76599089
18Submucous cleft hard palate (HP:0000176)2.74905352
19Nephroblastoma (Wilms tumor) (HP:0002667)2.65377448
20Curly hair (HP:0002212)2.65233810
21Abnormal hair whorl (HP:0010721)2.63535651
22Heterotopia (HP:0002282)2.61708651
23Drooling (HP:0002307)2.61110807
24Neoplasm of the oral cavity (HP:0100649)2.56400488
25Ectopic kidney (HP:0000086)2.54467415
26Embryonal renal neoplasm (HP:0011794)2.49765566
27Rhabdomyosarcoma (HP:0002859)2.49310604
28Gastrointestinal carcinoma (HP:0002672)2.46915403
29Malignant gastrointestinal tract tumors (HP:0006749)2.46915403
30Abnormality of the fingertips (HP:0001211)2.46518974
31Shallow orbits (HP:0000586)2.46247774
32Prominent nose (HP:0000448)2.43515467
33Excessive salivation (HP:0003781)2.39803829
34Abnormality of the labia minora (HP:0012880)2.37968559
35Papillary thyroid carcinoma (HP:0002895)2.34673579
36Deviation of the thumb (HP:0009603)2.28752963
37Cystic hygroma (HP:0000476)2.27876763
38Neoplasm of striated muscle (HP:0009728)2.27513860
39Long eyelashes (HP:0000527)2.26103496
40Genetic anticipation (HP:0003743)2.25413751
41Proximal placement of thumb (HP:0009623)2.24420885
42Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.24083831
43Biliary tract neoplasm (HP:0100574)2.23643922
44Abnormality of chromosome stability (HP:0003220)2.19985268
45Cerebral aneurysm (HP:0004944)2.17081113
46Macroorchidism (HP:0000053)2.16864635
47Transitional cell carcinoma of the bladder (HP:0006740)2.16087482
48Abnormality of the 4th metacarpal (HP:0010012)2.16012159
49Increased nuchal translucency (HP:0010880)2.12093140
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.11961266
51Febrile seizures (HP:0002373)2.11857331
52Fair hair (HP:0002286)2.07970988
53Bladder carcinoma (HP:0002862)2.07301204
54Bladder neoplasm (HP:0009725)2.07301204
55Narrow palate (HP:0000189)2.06554158
56Ankle contracture (HP:0006466)2.02162338
57Supernumerary ribs (HP:0005815)2.01678195
58High anterior hairline (HP:0009890)2.00993727
59Abnormality of the lower motor neuron (HP:0002366)1.99866602
60Leiomyosarcoma (HP:0100243)1.99066523
61Uterine leiomyosarcoma (HP:0002891)1.99066523
62Basal cell carcinoma (HP:0002671)1.98261247
63Hyperventilation (HP:0002883)1.97104595
64Truncal obesity (HP:0001956)1.96984513
65Severe Myopia (HP:0011003)1.96751336
66Sandal gap (HP:0001852)1.96597026
67Poor coordination (HP:0002370)1.96435861
68Skull defect (HP:0001362)1.93510681
69Hypopigmentation of the fundus (HP:0007894)1.93123054
70Ectropion (HP:0000656)1.92858858
71Trigonocephaly (HP:0000243)1.92166662
72Cupped ear (HP:0000378)1.91801914
73Hematochezia (HP:0002573)1.91179046
74Pelvic girdle muscle weakness (HP:0003749)1.86600490
75Renal cortical cysts (HP:0000803)1.86578569
76Intestinal atresia (HP:0011100)1.86086149
77Broad thumb (HP:0011304)1.86056170
78Vitreoretinal degeneration (HP:0000655)1.85061770
79Facial hemangioma (HP:0000329)1.84758667
80Highly arched eyebrow (HP:0002553)1.83652649
81Large earlobe (HP:0009748)1.83035471
82Neoplasm of the adrenal cortex (HP:0100641)1.82890772
83Abnormality of the renal cortex (HP:0011035)1.82853482
84Hypoplastic iliac wings (HP:0002866)1.82517705
85Abnormality of DNA repair (HP:0003254)1.82047637
86Hypoplastic labia majora (HP:0000059)1.81855598
87Anal stenosis (HP:0002025)1.81410691
88Abnormality of the septum pellucidum (HP:0007375)1.81287220
89Selective tooth agenesis (HP:0001592)1.80945852
90Menstrual irregularities (HP:0000858)1.80899201
91Aqueductal stenosis (HP:0002410)1.80214321
92Cutis marmorata (HP:0000965)1.79189751
93Protruding tongue (HP:0010808)1.78677392
94Abnormality of chromosome segregation (HP:0002916)1.77982284
95Spinal muscular atrophy (HP:0007269)1.76308354
96Cafe-au-lait spot (HP:0000957)1.76222857
97Mitral valve prolapse (HP:0001634)1.75226243
98Embryonal neoplasm (HP:0002898)1.73322336
99Amyotrophic lateral sclerosis (HP:0007354)1.73165237
100Broad palm (HP:0001169)1.72476439
101Absent frontal sinuses (HP:0002688)1.72462904
102Progressive cerebellar ataxia (HP:0002073)1.72410621
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.72364304
104Hip dysplasia (HP:0001385)1.71922171
105Oligodactyly (hands) (HP:0001180)1.71607962
106Sloping forehead (HP:0000340)1.71413269
107Intellectual disability, moderate (HP:0002342)1.71111380
108Meckel diverticulum (HP:0002245)1.70119839
109Pancreatic cysts (HP:0001737)1.69527693
110Abnormality of the left ventricular outflow tract (HP:0011103)1.69319151
111Subaortic stenosis (HP:0001682)1.69319151
112Diastasis recti (HP:0001540)1.69090005
113Exotropia (HP:0000577)1.68758906
114Uterine neoplasm (HP:0010784)1.68592612
115Failure to thrive in infancy (HP:0001531)1.68523415
116Low anterior hairline (HP:0000294)1.68409209
117Hypoplasia of the maxilla (HP:0000327)1.67834451
118Cortical dysplasia (HP:0002539)1.67340373
119Abnormality of the metopic suture (HP:0005556)1.65409777
120Azoospermia (HP:0000027)1.65265913
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.65080472
122Congenital primary aphakia (HP:0007707)1.64862986
123Supernumerary bones of the axial skeleton (HP:0009144)1.64530628
124Missing ribs (HP:0000921)1.64041988
125Broad phalanges of the hand (HP:0009768)1.63745472
126Urethral obstruction (HP:0000796)1.63464853
127Genu recurvatum (HP:0002816)1.63177727
128Wrist flexion contracture (HP:0001239)1.63011930
129Agnosia (HP:0010524)1.62847992
130Abdominal situs inversus (HP:0003363)1.62630915
131Abnormality of abdominal situs (HP:0011620)1.62630915
132Absent eyebrow (HP:0002223)1.62419005
133Pancreatic fibrosis (HP:0100732)1.61938911
134Abnormality of the labia majora (HP:0012881)1.61529131
135Widely spaced teeth (HP:0000687)1.61392137
136Deep philtrum (HP:0002002)1.60967149
137Labial hypoplasia (HP:0000066)1.60914510
138Short humerus (HP:0005792)1.60447980
139Renal duplication (HP:0000075)1.59554054
140Obsessive-compulsive behavior (HP:0000722)1.59052654
141Gait imbalance (HP:0002141)1.58656198
142Ulnar bowing (HP:0003031)1.58374207
143Termporal pattern (HP:0011008)1.57492632
144Insidious onset (HP:0003587)1.57492632
145Tubulointerstitial abnormality (HP:0001969)1.57095706
146Thick eyebrow (HP:0000574)1.56926089
147Abnormality of oral frenula (HP:0000190)1.56602287
148Abnormality of the ileum (HP:0001549)1.56438314
149Oligodactyly (HP:0012165)1.56075496
150Supernumerary spleens (HP:0009799)1.55875062
151Midline defect of the nose (HP:0004122)1.55779485
152Abnormality of the renal medulla (HP:0100957)1.55313109
153Skin tags (HP:0010609)1.55088061
154Micropenis (HP:0000054)1.55005478
155Abnormality of the carotid arteries (HP:0005344)1.54447345
156Bowel diverticulosis (HP:0005222)1.53707077
157Aortic aneurysm (HP:0004942)1.52908068
158Impulsivity (HP:0100710)1.51966336
159Absent radius (HP:0003974)1.51803241
160Hepatoblastoma (HP:0002884)1.49913539
161Ankyloglossia (HP:0010296)1.49109589
162Limited elbow extension (HP:0001377)1.48820922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.40047299
2CDC73.66839189
3MAP3K43.09704322
4LATS13.03986537
5EIF2AK32.53408217
6TRIM282.50993846
7NEK22.47182898
8BCR2.35154088
9MAP3K102.26109496
10ACVR1B2.08763008
11PKN22.03534616
12BRD42.02962399
13CASK1.96404988
14CAMK1D1.92043236
15EEF2K1.81335563
16WEE11.78148744
17STK31.71421188
18STK101.61926078
19CDK61.57261780
20MAPK131.48307128
21SIK31.47651065
22EPHA21.44921022
23MAP2K71.44725216
24STK38L1.43604581
25CHEK11.40801308
26SCYL21.38747423
27MAP3K61.36466475
28CHEK21.35988502
29CAMK1G1.35897382
30TTK1.34809435
31ATR1.34507030
32NUAK11.34417618
33CLK11.33723983
34TNIK1.33577430
35ERBB31.33487533
36MELK1.31344525
37ALK1.31244466
38FGFR31.26990776
39MTOR1.26470534
40FGFR21.26087936
41PLK11.25155277
42CDK41.25049220
43SRPK11.24013290
44PLK21.20626688
45RIPK11.20489215
46YES11.20132132
47NEK61.19060131
48ATM1.18916044
49CDK91.18479829
50FGFR11.17641202
51RPS6KB21.17365928
52PLK31.16234381
53BMPR21.16132431
54NEK11.14006046
55STK41.13950850
56TRIB31.13574352
57WNK31.09693393
58AURKB1.03222302
59FLT31.02120357
60TTN1.01822447
61LATS21.01540313
62PDGFRA1.00987342
63CAMK41.00487744
64BRSK20.99877617
65SGK20.99666184
66CDK20.94410232
67PDK20.93600111
68EPHA30.93402720
69TGFBR10.93373254
70CAMKK20.90440152
71PTK60.89552318
72CDK70.89292221
73PASK0.88354737
74PIM10.87189077
75MAP3K80.85188222
76MAP2K40.84970553
77NEK90.84704765
78RPS6KA40.82031443
79BMPR1B0.81850745
80PDGFRB0.80389674
81DYRK1A0.79140606
82ZAK0.78791389
83MARK10.78480859
84CSK0.78400807
85KSR10.77599318
86NLK0.77485515
87WNK10.75671258
88FRK0.75333791
89TGFBR20.74712217
90MAP4K20.73873717
91MAP4K10.73797149
92CSNK1D0.73533106
93SIK20.73078308
94CDK10.73020339
95MARK30.72394643
96PKN10.72254107
97BMX0.70712823
98DYRK1B0.69580799
99DYRK30.69382537
100CCNB10.68270679
101EPHA40.67576863
102MAP3K20.67516774
103MAP3K30.67449200
104PNCK0.66998286
105MKNK10.66424123
106MKNK20.65614177
107PRKDC0.63229838
108SGK30.63045656
109PAK40.61863147
110IRAK20.61827096
111CHUK0.58579621
112EIF2AK20.57719446
113IRAK10.57070914
114TEC0.56768809
115MAPK140.56690782
116ITK0.55988608
117TYRO30.55792045
118MAP3K50.55622451
119DDR20.55525125
120SGK2230.55228007
121SGK4940.55228007
122PAK20.54997355
123DMPK0.54866285
124PRKAA10.53701161
125CSF1R0.52856701
126TSSK60.52171869
127PTK20.50850722
128MAP2K30.49909620
129MARK20.49657524
130GRK60.49530833
131CSNK1A1L0.48642457
132RET0.47887172
133PLK40.47676345
134TLK10.47115740
135CDK30.47088906
136MST40.46453165
137MAPK10.46400941
138AKT30.46307577
139RAF10.46018027
140INSRR0.45635393
141GSK3B0.44360560
142JAK10.43652444
143AKT10.43565185
144STK240.43282379
145MAPK100.43208904
146RPS6KB10.41177856
147PBK0.40479073
148CSNK1E0.39805112
149JAK30.39015473
150FER0.38572422
151EIF2AK10.37710702
152ERBB20.37655215

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047102.32994039
2Cell cycle_Homo sapiens_hsa041102.20407127
3Systemic lupus erythematosus_Homo sapiens_hsa053222.12995768
4RNA transport_Homo sapiens_hsa030132.05454071
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95669290
6mRNA surveillance pathway_Homo sapiens_hsa030151.94779282
7MicroRNAs in cancer_Homo sapiens_hsa052061.78054379
8Adherens junction_Homo sapiens_hsa045201.77229533
9mTOR signaling pathway_Homo sapiens_hsa041501.73304402
10Mismatch repair_Homo sapiens_hsa034301.65087059
11Fanconi anemia pathway_Homo sapiens_hsa034601.61619228
12p53 signaling pathway_Homo sapiens_hsa041151.60357714
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.58023767
14Viral carcinogenesis_Homo sapiens_hsa052031.55241195
15DNA replication_Homo sapiens_hsa030301.52484473
16Colorectal cancer_Homo sapiens_hsa052101.48207861
17Spliceosome_Homo sapiens_hsa030401.46290386
18Non-homologous end-joining_Homo sapiens_hsa034501.45612278
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44290403
20Small cell lung cancer_Homo sapiens_hsa052221.44181193
21Chronic myeloid leukemia_Homo sapiens_hsa052201.43847604
22One carbon pool by folate_Homo sapiens_hsa006701.39921970
23Lysine degradation_Homo sapiens_hsa003101.36548224
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35193069
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30037273
26Hippo signaling pathway_Homo sapiens_hsa043901.28563714
27Proteoglycans in cancer_Homo sapiens_hsa052051.27679946
28Endometrial cancer_Homo sapiens_hsa052131.24878582
29HTLV-I infection_Homo sapiens_hsa051661.23162907
30Regulation of autophagy_Homo sapiens_hsa041401.23053179
31TGF-beta signaling pathway_Homo sapiens_hsa043501.20668354
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20487882
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16370862
34Nicotine addiction_Homo sapiens_hsa050331.16361776
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14080809
36Herpes simplex infection_Homo sapiens_hsa051681.13290028
37Oocyte meiosis_Homo sapiens_hsa041141.13218986
38Pancreatic cancer_Homo sapiens_hsa052121.13206745
39Alcoholism_Homo sapiens_hsa050341.12804003
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10627115
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09258641
42Basal cell carcinoma_Homo sapiens_hsa052171.07033457
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.06695687
44Viral myocarditis_Homo sapiens_hsa054161.06112283
45Dorso-ventral axis formation_Homo sapiens_hsa043201.05328848
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.04880638
47FoxO signaling pathway_Homo sapiens_hsa040681.03858386
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03407759
49Prostate cancer_Homo sapiens_hsa052151.02469439
50Antigen processing and presentation_Homo sapiens_hsa046121.02006902
51Renal cell carcinoma_Homo sapiens_hsa052110.99550065
52Legionellosis_Homo sapiens_hsa051340.98560660
53Focal adhesion_Homo sapiens_hsa045100.98143071
54Nucleotide excision repair_Homo sapiens_hsa034200.97677183
55Notch signaling pathway_Homo sapiens_hsa043300.96580160
56Non-small cell lung cancer_Homo sapiens_hsa052230.96567731
57RNA degradation_Homo sapiens_hsa030180.94592410
58Hepatitis B_Homo sapiens_hsa051610.93357832
59Base excision repair_Homo sapiens_hsa034100.93161921
60T cell receptor signaling pathway_Homo sapiens_hsa046600.92932573
61Epstein-Barr virus infection_Homo sapiens_hsa051690.92384755
62B cell receptor signaling pathway_Homo sapiens_hsa046620.92235020
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.90137408
64Homologous recombination_Homo sapiens_hsa034400.89168386
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89039762
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.88496990
67Choline metabolism in cancer_Homo sapiens_hsa052310.87361497
68Pathways in cancer_Homo sapiens_hsa052000.85888328
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85667733
70Fatty acid biosynthesis_Homo sapiens_hsa000610.84413739
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83683578
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82792354
73Glioma_Homo sapiens_hsa052140.82683130
74Acute myeloid leukemia_Homo sapiens_hsa052210.82279279
75Basal transcription factors_Homo sapiens_hsa030220.81586657
76Selenocompound metabolism_Homo sapiens_hsa004500.80876444
77Olfactory transduction_Homo sapiens_hsa047400.80556317
78Bladder cancer_Homo sapiens_hsa052190.79720469
79Wnt signaling pathway_Homo sapiens_hsa043100.79597598
80Toxoplasmosis_Homo sapiens_hsa051450.79109081
81Tight junction_Homo sapiens_hsa045300.76932371
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75318251
83Osteoclast differentiation_Homo sapiens_hsa043800.75085681
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75063366
85HIF-1 signaling pathway_Homo sapiens_hsa040660.74773068
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73548569
87Apoptosis_Homo sapiens_hsa042100.72333961
88TNF signaling pathway_Homo sapiens_hsa046680.71512035
89Type II diabetes mellitus_Homo sapiens_hsa049300.71262155
90Insulin resistance_Homo sapiens_hsa049310.70765162
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70460785
92Steroid biosynthesis_Homo sapiens_hsa001000.69221393
93Thyroid cancer_Homo sapiens_hsa052160.68894053
94Influenza A_Homo sapiens_hsa051640.68127316
95Leishmaniasis_Homo sapiens_hsa051400.67890929
96AMPK signaling pathway_Homo sapiens_hsa041520.67157277
97Inositol phosphate metabolism_Homo sapiens_hsa005620.66841934
98VEGF signaling pathway_Homo sapiens_hsa043700.65930754
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65797442
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.65584173
101Measles_Homo sapiens_hsa051620.65464559
102ECM-receptor interaction_Homo sapiens_hsa045120.65085236
103Platelet activation_Homo sapiens_hsa046110.64757090
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64027622
105Axon guidance_Homo sapiens_hsa043600.62375240
106Hedgehog signaling pathway_Homo sapiens_hsa043400.61725566
107Dopaminergic synapse_Homo sapiens_hsa047280.60246185
108Estrogen signaling pathway_Homo sapiens_hsa049150.59618103
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59262148
110Glutamatergic synapse_Homo sapiens_hsa047240.58533134
111Propanoate metabolism_Homo sapiens_hsa006400.58487073
112Prolactin signaling pathway_Homo sapiens_hsa049170.58296246
113Phototransduction_Homo sapiens_hsa047440.58233388
114Long-term depression_Homo sapiens_hsa047300.57893704
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.56797175
116ErbB signaling pathway_Homo sapiens_hsa040120.56568193
117Rap1 signaling pathway_Homo sapiens_hsa040150.55959393
118MAPK signaling pathway_Homo sapiens_hsa040100.55343414
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54842766
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53737626
121Amoebiasis_Homo sapiens_hsa051460.53526443
122Insulin signaling pathway_Homo sapiens_hsa049100.52324337
123Melanoma_Homo sapiens_hsa052180.50486393
124GnRH signaling pathway_Homo sapiens_hsa049120.49890815
125Taste transduction_Homo sapiens_hsa047420.47830854
126Long-term potentiation_Homo sapiens_hsa047200.47218877
127Cholinergic synapse_Homo sapiens_hsa047250.46061004
128Sphingolipid metabolism_Homo sapiens_hsa006000.45174573
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44140418
130Morphine addiction_Homo sapiens_hsa050320.43917061
131cAMP signaling pathway_Homo sapiens_hsa040240.42458024

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