RLIM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.37974876
2nuclear pore organization (GO:0006999)6.03500188
3cytoplasmic mRNA processing body assembly (GO:0033962)4.78272193
4pore complex assembly (GO:0046931)4.76080751
5mitotic sister chromatid cohesion (GO:0007064)4.56239156
6regulation of RNA export from nucleus (GO:0046831)4.36485857
7mitotic nuclear envelope disassembly (GO:0007077)4.27423018
8embryonic process involved in female pregnancy (GO:0060136)4.09678535
9nuclear envelope disassembly (GO:0051081)4.04378895
10membrane disassembly (GO:0030397)4.04378895
11replication fork processing (GO:0031297)3.91342406
12protein localization to kinetochore (GO:0034501)3.83417000
13negative regulation of DNA repair (GO:0045738)3.76294003
14pre-miRNA processing (GO:0031054)3.72573282
15regulation of posttranscriptional gene silencing (GO:0060147)3.67414778
16regulation of gene silencing by miRNA (GO:0060964)3.67414778
17regulation of gene silencing by RNA (GO:0060966)3.67414778
18positive regulation of mitotic sister chromatid separation (GO:1901970)3.67030200
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.67030200
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.67030200
21negative regulation of histone methylation (GO:0031061)3.58019724
22maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.57487229
23* dosage compensation (GO:0007549)3.54702415
24sister chromatid segregation (GO:0000819)3.52787796
25regulation of sister chromatid cohesion (GO:0007063)3.51887469
26histone H2A monoubiquitination (GO:0035518)3.51623414
27positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.48576581
28kinetochore organization (GO:0051383)3.45070298
29regulation of nucleobase-containing compound transport (GO:0032239)3.45028948
30mitotic metaphase plate congression (GO:0007080)3.43455375
31regulation of histone H3-K9 methylation (GO:0051570)3.41313145
32regulation of spindle organization (GO:0090224)3.34323637
33meiotic chromosome segregation (GO:0045132)3.34020505
34regulation of transforming growth factor beta2 production (GO:0032909)3.33158522
35DNA unwinding involved in DNA replication (GO:0006268)3.31913281
36mitotic chromosome condensation (GO:0007076)3.31757637
37somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31337164
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.31337164
39phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.31289460
40positive regulation of chromosome segregation (GO:0051984)3.28681815
41histone H3-K36 demethylation (GO:0070544)3.26503703
42DNA topological change (GO:0006265)3.25005796
43nuclear envelope organization (GO:0006998)3.24803732
44regulation of centrosome cycle (GO:0046605)3.24677818
45DNA duplex unwinding (GO:0032508)3.23723349
46regulation of NFAT protein import into nucleus (GO:0051532)3.22663654
47DNA geometric change (GO:0032392)3.22498159
48interkinetic nuclear migration (GO:0022027)3.22016022
49DNA replication-dependent nucleosome organization (GO:0034723)3.21228289
50DNA replication-dependent nucleosome assembly (GO:0006335)3.21228289
51mitotic sister chromatid segregation (GO:0000070)3.20494447
52regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.17911125
53regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17535996
54monoubiquitinated protein deubiquitination (GO:0035520)3.14350446
55histone mRNA catabolic process (GO:0071044)3.10352778
56DNA replication initiation (GO:0006270)3.07624880
57metaphase plate congression (GO:0051310)3.07559789
58protein localization to chromosome, centromeric region (GO:0071459)3.07095528
59protein K6-linked ubiquitination (GO:0085020)3.03427256
60regulation of centrosome duplication (GO:0010824)3.03022163
61mRNA transport (GO:0051028)3.02323599
62protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.00676684
63paraxial mesoderm development (GO:0048339)3.00199600
64positive regulation of DNA-templated transcription, initiation (GO:2000144)2.97768457
65negative regulation of neurotransmitter secretion (GO:0046929)2.96807624
66nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.95631364
67DNA strand renaturation (GO:0000733)2.94826996
68cellular response to ethanol (GO:0071361)2.94344621
69NLS-bearing protein import into nucleus (GO:0006607)2.94269910
70regulation of mitotic spindle organization (GO:0060236)2.94032951
71establishment of nucleus localization (GO:0040023)2.91934176
72kinetochore assembly (GO:0051382)2.91614537
73protein K11-linked deubiquitination (GO:0035871)2.90395982
74peptidyl-threonine modification (GO:0018210)2.90318013
75regulation of protein polyubiquitination (GO:1902914)2.89391498
76protein K48-linked deubiquitination (GO:0071108)2.87336991
77iron ion import (GO:0097286)2.87226034
78regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86782060
79spindle checkpoint (GO:0031577)2.85592158
80histone demethylation (GO:0016577)2.85499590
81DNA double-strand break processing (GO:0000729)2.84640342
82chromatin assembly (GO:0031497)2.83705457
83peptidyl-threonine phosphorylation (GO:0018107)2.83427420
84histone lysine demethylation (GO:0070076)2.82623746
85lipid translocation (GO:0034204)2.81467251
86phospholipid translocation (GO:0045332)2.81467251
87negative regulation of chromosome segregation (GO:0051985)2.81382027
88regulation of centriole replication (GO:0046599)2.80702014
89peptidyl-lysine dimethylation (GO:0018027)2.80652270
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79170774
91nucleus organization (GO:0006997)2.78633472
92regulation of DNA endoreduplication (GO:0032875)2.78599845
93ribosome assembly (GO:0042255)2.77746789
94spindle assembly involved in mitosis (GO:0090307)2.77537391
95nucleus localization (GO:0051647)2.76979335
96chromosome segregation (GO:0007059)2.76879927
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75924542
98microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.75463711
99morphogenesis of an epithelial sheet (GO:0002011)2.74838114
100spindle assembly checkpoint (GO:0071173)2.74103973
101regulation of sister chromatid segregation (GO:0033045)2.72915874
102regulation of mitotic sister chromatid separation (GO:0010965)2.72915874
103regulation of mitotic sister chromatid segregation (GO:0033047)2.72915874
104regulation of chromosome segregation (GO:0051983)2.72747930
105mitotic spindle checkpoint (GO:0071174)2.72549084
106regulation of helicase activity (GO:0051095)2.72456140
107histone H3-K4 trimethylation (GO:0080182)2.71057318
108positive regulation of SMAD protein import into nucleus (GO:0060391)2.68817104
109stress granule assembly (GO:0034063)2.68795560
110peptidyl-lysine trimethylation (GO:0018023)2.68702843
111trophectodermal cell differentiation (GO:0001829)2.68294210
112establishment of chromosome localization (GO:0051303)2.67723542
113histone H4-K12 acetylation (GO:0043983)2.67420501
114regulation of double-strand break repair (GO:2000779)2.66477830
115negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.65524595
116RNA transport (GO:0050658)2.65033182
117establishment of RNA localization (GO:0051236)2.65033182
118nucleic acid transport (GO:0050657)2.65033182
119mitotic spindle assembly checkpoint (GO:0007094)2.64941175
120sister chromatid cohesion (GO:0007062)2.64813424
121IMP biosynthetic process (GO:0006188)2.64725523
122regulation of gene silencing (GO:0060968)2.64436485
123chromatin remodeling at centromere (GO:0031055)2.63636226
124regulation of translational fidelity (GO:0006450)2.63599681
125mitotic recombination (GO:0006312)2.63345501
126regulation of histone H3-K27 methylation (GO:0061085)2.62875907
127histone H3-K9 demethylation (GO:0033169)2.62737977
128folic acid-containing compound biosynthetic process (GO:0009396)2.62635969
129regulation of DNA damage checkpoint (GO:2000001)2.61929901
130definitive hemopoiesis (GO:0060216)2.61725742
131COPII vesicle coating (GO:0048208)2.61116594
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.61085782
133negative regulation of sister chromatid segregation (GO:0033046)2.61085782
134negative regulation of mitotic sister chromatid separation (GO:2000816)2.61085782
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.61085782
136regulation of pigment cell differentiation (GO:0050932)2.60227951
137double-strand break repair via nonhomologous end joining (GO:0006303)2.59716794
138non-recombinational repair (GO:0000726)2.59716794
139peptidyl-threonine dephosphorylation (GO:0035970)2.56303490
140positive regulation of cell cycle checkpoint (GO:1901978)2.53099773
141protein export from nucleus (GO:0006611)2.52283965
142protein demethylation (GO:0006482)2.48340696
143protein dealkylation (GO:0008214)2.48340696
144glucocorticoid receptor signaling pathway (GO:0042921)2.44280867
145regulation of Rac protein signal transduction (GO:0035020)2.40618641
146histone-serine phosphorylation (GO:0035404)2.39582058
147embryonic camera-type eye morphogenesis (GO:0048596)2.39414486
148snRNA transcription (GO:0009301)2.39244266
149cytoskeleton-dependent cytokinesis (GO:0061640)2.36339852
150Golgi to endosome transport (GO:0006895)2.36293578
151peptidyl-lysine methylation (GO:0018022)2.35291901
152protein destabilization (GO:0031648)2.34394155
153positive regulation of developmental pigmentation (GO:0048087)2.32839504
154histone phosphorylation (GO:0016572)2.32021849
155positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.30948823
156positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.30827409
157regulation of DNA-templated transcription, initiation (GO:2000142)2.30752880
158histone lysine methylation (GO:0034968)2.30564752
159DNA synthesis involved in DNA repair (GO:0000731)2.29886251
160peptidyl-serine phosphorylation (GO:0018105)2.29599985
161regulation of oxidative stress-induced neuron death (GO:1903203)2.26735247
162corticosteroid receptor signaling pathway (GO:0031958)2.25248745
163negative regulation of TOR signaling (GO:0032007)2.25219364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.44886605
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.71326610
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.23655038
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.18488616
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.92397699
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76573919
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.27494093
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.92005113
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90780848
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.76994009
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.70024150
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.42599758
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.41624860
14GATA1_22025678_ChIP-Seq_K562_Human2.40920590
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40890960
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22057368
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.20624758
18AR_21909140_ChIP-Seq_LNCAP_Human2.17978362
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17883133
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.13970913
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04205127
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91676321
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88525028
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88230037
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88200502
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81002234
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74888085
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74626882
29TAF15_26573619_Chip-Seq_HEK293_Human1.72001710
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68910215
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68910215
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68910215
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67900094
34TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.67220629
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65771236
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65141700
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64000210
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63739140
39ELK1_19687146_ChIP-ChIP_HELA_Human1.62771362
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62222296
41FUS_26573619_Chip-Seq_HEK293_Human1.60265546
42TP53_16413492_ChIP-PET_HCT116_Human1.60169299
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57535694
44MYC_22102868_ChIP-Seq_BL_Human1.57330404
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53117093
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.51675266
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50858699
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.49875863
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47442749
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46373141
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45044598
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43341533
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43227412
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43128730
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42945562
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42166986
57SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37602825
58AHR_22903824_ChIP-Seq_MCF-7_Human1.37521995
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37261379
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36771614
61* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35945629
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34028364
63GBX2_23144817_ChIP-Seq_PC3_Human1.33724182
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33088699
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.33026776
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32488555
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31869206
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31390861
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30623223
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30174135
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28327888
72IGF1R_20145208_ChIP-Seq_DFB_Human1.27718673
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27568446
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27568446
75TFEB_21752829_ChIP-Seq_HELA_Human1.27489342
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27467057
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26629500
78EWS_26573619_Chip-Seq_HEK293_Human1.26349194
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26198113
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23930668
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.22023552
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21549558
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20983787
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20845548
85KDM5A_27292631_Chip-Seq_BREAST_Human1.20306157
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20271050
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20181731
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20090094
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19475293
90STAT3_23295773_ChIP-Seq_U87_Human1.19450014
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17065384
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.17041481
93SMAD4_21799915_ChIP-Seq_A2780_Human1.17014707
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16827110
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16275809
96* VDR_23849224_ChIP-Seq_CD4+_Human1.16077120
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15341778
98E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15247864
99XRN2_22483619_ChIP-Seq_HELA_Human1.14759387
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.14594060
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14105074
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13084577
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12859646
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12318368
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09330119
106* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09268727
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08998608
108TP63_17297297_ChIP-ChIP_HaCaT_Human1.07564667
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.06780720
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06111592
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04917114
112* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04255722
113CHD1_26751641_Chip-Seq_LNCaP_Human1.03358174
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02711060
115TTF2_22483619_ChIP-Seq_HELA_Human1.02570953
116CLOCK_20551151_ChIP-Seq_293T_Human1.01945055
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01724242
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01433192
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01314070
120AR_21572438_ChIP-Seq_LNCaP_Human1.01149136
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00518773
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99816049
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98961296
124BRD4_25478319_ChIP-Seq_HGPS_Human0.98665782
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98510262
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98169186
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95529646
128FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94995149
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93928602
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93857875
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93492692
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92924800
133SOX9_26525672_Chip-Seq_HEART_Mouse0.92507769
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91864280
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91635719
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91288230
137POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91190120
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90251359
139GABP_19822575_ChIP-Seq_HepG2_Human0.88744057
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.88371222
141RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88162559
142TCF4_23295773_ChIP-Seq_U87_Human0.87839853
143CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87354479
144SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86184768
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85537299
146SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85351666
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85262163
148SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85262163
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85180602
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.85028408
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84569507
152EST1_17652178_ChIP-ChIP_JURKAT_Human0.84478341
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.84205251
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.83931433
155E2F1_18555785_Chip-Seq_ESCs_Mouse0.83883779
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83760762
157TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.83699160
158SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83690122
159POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83559074
160PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83094210
161SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81747311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.78303254
2MP0010352_gastrointestinal_tract_polyps3.13078133
3MP0010094_abnormal_chromosome_stability3.12725352
4MP0003693_abnormal_embryo_hatching2.82245342
5MP0003111_abnormal_nucleus_morphology2.62175266
6MP0004957_abnormal_blastocyst_morpholog2.51953825
7MP0003077_abnormal_cell_cycle2.49711686
8MP0003123_paternal_imprinting2.38838313
9MP0010307_abnormal_tumor_latency2.37824174
10MP0003121_genomic_imprinting2.34063283
11MP0005076_abnormal_cell_differentiation2.22476872
12MP0000569_abnormal_digit_pigmentation2.16373796
13MP0005409_darkened_coat_color2.15685857
14MP0010030_abnormal_orbit_morphology2.07204294
15MP0008877_abnormal_DNA_methylation2.03034447
16MP0008007_abnormal_cellular_replicative2.01008341
17MP0003890_abnormal_embryonic-extraembry2.00125285
18MP0000350_abnormal_cell_proliferation1.88862812
19MP0003787_abnormal_imprinting1.87168866
20MP0003705_abnormal_hypodermis_morpholog1.87129981
21MP0003656_abnormal_erythrocyte_physiolo1.85773763
22MP0002877_abnormal_melanocyte_morpholog1.85681598
23MP0002009_preneoplasia1.84135243
24MP0004197_abnormal_fetal_growth/weight/1.83333080
25MP0009053_abnormal_anal_canal1.82687752
26* MP0002086_abnormal_extraembryonic_tissu1.78378572
27MP0002084_abnormal_developmental_patter1.77290874
28MP0001730_embryonic_growth_arrest1.73918599
29MP0008058_abnormal_DNA_repair1.73824165
30* MP0005380_embryogenesis_phenotype1.71957935
31* MP0001672_abnormal_embryogenesis/_devel1.71957935
32MP0005171_absent_coat_pigmentation1.71572789
33MP0003984_embryonic_growth_retardation1.65714487
34MP0001697_abnormal_embryo_size1.65473082
35MP0002088_abnormal_embryonic_growth/wei1.62890768
36MP0003566_abnormal_cell_adhesion1.62562184
37MP0004185_abnormal_adipocyte_glucose1.59734988
38MP0003221_abnormal_cardiomyocyte_apopto1.58670538
39MP0003786_premature_aging1.54515531
40MP0000383_abnormal_hair_follicle1.51417920
41MP0002085_abnormal_embryonic_tissue1.51369163
42MP0000371_diluted_coat_color1.49086885
43MP0008932_abnormal_embryonic_tissue1.49031590
44MP0001293_anophthalmia1.45246529
45MP0004264_abnormal_extraembryonic_tissu1.45109071
46MP0005187_abnormal_penis_morphology1.44860450
47MP0003950_abnormal_plasma_membrane1.43617827
48MP0003828_pulmonary_edema1.38889899
49MP0002396_abnormal_hematopoietic_system1.38202226
50MP0003567_abnormal_fetal_cardiomyocyte1.37410686
51MP0008961_abnormal_basal_metabolism1.34332056
52MP0004808_abnormal_hematopoietic_stem1.30769691
53MP0003119_abnormal_digestive_system1.29954394
54MP0000372_irregular_coat_pigmentation1.28536795
55MP0000490_abnormal_crypts_of1.26337920
56MP0009278_abnormal_bone_marrow1.21994536
57* MP0002080_prenatal_lethality1.21626493
58MP0003937_abnormal_limbs/digits/tail_de1.21486285
59MP0005023_abnormal_wound_healing1.19091420
60MP0003941_abnormal_skin_development1.14579203
61MP0000427_abnormal_hair_cycle1.13906545
62MP0005408_hypopigmentation1.11305380
63MP0005397_hematopoietic_system_phenotyp1.09761142
64MP0001545_abnormal_hematopoietic_system1.09761142
65MP0008438_abnormal_cutaneous_collagen1.08197258
66MP0010234_abnormal_vibrissa_follicle1.04308319
67MP0005623_abnormal_meninges_morphology1.02985176
68MP0003935_abnormal_craniofacial_develop1.02430310
69MP0000432_abnormal_head_morphology1.01761887
70MP0009703_decreased_birth_body1.00772876
71MP0003755_abnormal_palate_morphology1.00152676
72MP0002111_abnormal_tail_morphology0.99660634
73MP0003091_abnormal_cell_migration0.99351803
74MP0001915_intracranial_hemorrhage0.98706903
75MP0003122_maternal_imprinting0.96422432
76MP0003453_abnormal_keratinocyte_physiol0.94360909
77MP0008995_early_reproductive_senescence0.93576535
78MP0002075_abnormal_coat/hair_pigmentati0.92658819
79MP0000313_abnormal_cell_death0.92611379
80MP0009697_abnormal_copulation0.92088783
81MP0006054_spinal_hemorrhage0.92026995
82MP0002019_abnormal_tumor_incidence0.91430177
83MP0005367_renal/urinary_system_phenotyp0.91214287
84MP0000516_abnormal_urinary_system0.91214287
85MP0002925_abnormal_cardiovascular_devel0.90067322
86MP0001177_atelectasis0.88108222
87MP0003763_abnormal_thymus_physiology0.87797634
88MP0002092_abnormal_eye_morphology0.87680044
89MP0002938_white_spotting0.87225007
90MP0000733_abnormal_muscle_development0.86866621
91MP0004130_abnormal_muscle_cell0.86385485
92MP0002332_abnormal_exercise_endurance0.85586350
93MP0004133_heterotaxia0.84306259
94MP0002006_tumorigenesis0.84239042
95MP0002697_abnormal_eye_size0.83781867
96MP0000537_abnormal_urethra_morphology0.82789069
97MP0001661_extended_life_span0.81535921
98MP0001186_pigmentation_phenotype0.80636108
99MP0000428_abnormal_craniofacial_morphol0.80456847
100MP0005508_abnormal_skeleton_morphology0.80379294
101MP0003115_abnormal_respiratory_system0.79655545
102MP0002166_altered_tumor_susceptibility0.78548710
103MP0001286_abnormal_eye_development0.78494377
104MP0005621_abnormal_cell_physiology0.78353731
105MP0000377_abnormal_hair_follicle0.78067728
106MP0000627_abnormal_mammary_gland0.73828332
107MP0000778_abnormal_nervous_system0.73626853
108MP0003045_fibrosis0.73581249
109MP0003300_gastrointestinal_ulcer0.72416018
110MP0000003_abnormal_adipose_tissue0.71254913
111MP0005384_cellular_phenotype0.70634119
112MP0001119_abnormal_female_reproductive0.69600134
113MP0002060_abnormal_skin_morphology0.69360533
114MP0001849_ear_inflammation0.69311332
115MP0003385_abnormal_body_wall0.69199730
116MP0001784_abnormal_fluid_regulation0.68702078
117MP0003632_abnormal_nervous_system0.68490960
118MP0004811_abnormal_neuron_physiology0.67638934
119MP0003943_abnormal_hepatobiliary_system0.67586058
120MP0005257_abnormal_intraocular_pressure0.66901512
121MP0002282_abnormal_trachea_morphology0.66806208
122MP0004233_abnormal_muscle_weight0.66485861
123MP0010678_abnormal_skin_adnexa0.66378187
124MP0003861_abnormal_nervous_system0.63761496
125MP0010630_abnormal_cardiac_muscle0.63611757
126MP0009672_abnormal_birth_weight0.63271489
127MP0002896_abnormal_bone_mineralization0.60781683
128MP0001879_abnormal_lymphatic_vessel0.60344923
129MP0001851_eye_inflammation0.60089953
130MP0004084_abnormal_cardiac_muscle0.59693650
131MP0002081_perinatal_lethality0.59345028
132MP0002114_abnormal_axial_skeleton0.56848644
133MP0001191_abnormal_skin_condition0.55989855
134MP0001299_abnormal_eye_distance/0.55603170
135MP0005083_abnormal_biliary_tract0.55467214
136MP0003634_abnormal_glial_cell0.55177474
137MP0005375_adipose_tissue_phenotype0.54221376

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.75614955
2Birth length less than 3rd percentile (HP:0003561)3.57915886
3Abnormality of the labia minora (HP:0012880)3.29332577
4Facial hemangioma (HP:0000329)3.07696829
5Dysmetric saccades (HP:0000641)2.96715946
6Neoplasm of the oral cavity (HP:0100649)2.87138689
7Chromsome breakage (HP:0040012)2.82796165
8Syringomyelia (HP:0003396)2.76097386
9Spinal cord lesions (HP:0100561)2.76097386
10Thyroid carcinoma (HP:0002890)2.75751779
11Relative macrocephaly (HP:0004482)2.69577849
12Insidious onset (HP:0003587)2.69561667
13Termporal pattern (HP:0011008)2.69561667
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60266398
15Selective tooth agenesis (HP:0001592)2.60215612
16Vertebral arch anomaly (HP:0008438)2.57352476
17Lip pit (HP:0100267)2.47512722
18Macroorchidism (HP:0000053)2.45699649
19Shawl scrotum (HP:0000049)2.44114322
20Medulloblastoma (HP:0002885)2.42934875
21Patellar aplasia (HP:0006443)2.42465754
22Ependymoma (HP:0002888)2.38186516
23Deviation of the thumb (HP:0009603)2.35036083
24Abnormality of chromosome stability (HP:0003220)2.33944653
25Abnormality of the distal phalanx of the thumb (HP:0009617)2.33239738
26Short humerus (HP:0005792)2.31515935
27Abnormality of the astrocytes (HP:0100707)2.30613898
28Astrocytoma (HP:0009592)2.30613898
29Narrow palate (HP:0000189)2.28775851
30Papillary thyroid carcinoma (HP:0002895)2.27436793
31Aplasia/Hypoplasia of the patella (HP:0006498)2.27112810
32Menstrual irregularities (HP:0000858)2.22845838
33Hypopigmentation of the fundus (HP:0007894)2.22528217
34Ectopic kidney (HP:0000086)2.20057795
35Rhabdomyosarcoma (HP:0002859)2.20038567
36Ankyloglossia (HP:0010296)2.19511240
37Breast hypoplasia (HP:0003187)2.18905222
38Deep philtrum (HP:0002002)2.17949938
39Pheochromocytoma (HP:0002666)2.16381355
40Increased number of teeth (HP:0011069)2.15919809
41Aplasia/hypoplasia of the humerus (HP:0006507)2.15609358
42Overgrowth (HP:0001548)2.15548232
43Curly hair (HP:0002212)2.14949376
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14419114
45Short 4th metacarpal (HP:0010044)2.14419114
46Absent frontal sinuses (HP:0002688)2.14132088
47Asymmetry of the thorax (HP:0001555)2.14034152
48Large earlobe (HP:0009748)2.12137124
49Absent radius (HP:0003974)2.11921494
50Abnormality of the nasal septum (HP:0000419)2.11758978
51Short chin (HP:0000331)2.08909343
52Hypoplastic labia majora (HP:0000059)2.08489559
53Sparse lateral eyebrow (HP:0005338)2.07471464
54Acute myeloid leukemia (HP:0004808)2.07054067
55Transitional cell carcinoma of the bladder (HP:0006740)2.07053244
56Proximal placement of thumb (HP:0009623)2.06741717
57Fair hair (HP:0002286)2.06276281
58Capillary hemangiomas (HP:0005306)2.06271087
59Cubitus valgus (HP:0002967)2.05965606
60Abnormality of the fingertips (HP:0001211)2.05769616
61Abnormality of the phalanges of the hallux (HP:0010057)2.04396472
62Open mouth (HP:0000194)2.02566198
63Gastrointestinal carcinoma (HP:0002672)2.02461854
64Malignant gastrointestinal tract tumors (HP:0006749)2.02461854
65Biliary tract neoplasm (HP:0100574)2.02242381
66Glioma (HP:0009733)2.01178280
67Rib fusion (HP:0000902)2.00794505
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.00040274
69Osteolytic defects of the hand bones (HP:0009699)2.00040274
70Intestinal atresia (HP:0011100)1.99997624
71Heterotopia (HP:0002282)1.99508069
72Bladder neoplasm (HP:0009725)1.99114716
73Bladder carcinoma (HP:0002862)1.99114716
74Colon cancer (HP:0003003)1.97070257
75Low anterior hairline (HP:0000294)1.95506333
76Aplasia involving forearm bones (HP:0009822)1.93949528
77Absent forearm bone (HP:0003953)1.93949528
78Leiomyosarcoma (HP:0100243)1.93463518
79Uterine leiomyosarcoma (HP:0002891)1.93463518
80Abnormality of oral frenula (HP:0000190)1.92449628
81Smooth philtrum (HP:0000319)1.92281417
82Neonatal hypoglycemia (HP:0001998)1.91644340
83Myelodysplasia (HP:0002863)1.91324912
84Broad thumb (HP:0011304)1.90697084
85Agnosia (HP:0010524)1.89925402
86Premature graying of hair (HP:0002216)1.89681500
87Prominent nose (HP:0000448)1.88039144
88Dislocated radial head (HP:0003083)1.87763220
89Abnormality of the labia majora (HP:0012881)1.87514056
90Abdominal situs inversus (HP:0003363)1.87403386
91Abnormality of abdominal situs (HP:0011620)1.87403386
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87051952
93Subacute progressive viral hepatitis (HP:0006572)1.85906530
94Long eyelashes (HP:0000527)1.85842915
95Ulnar bowing (HP:0003031)1.85239810
9611 pairs of ribs (HP:0000878)1.85233170
97Missing ribs (HP:0000921)1.84946240
98Abnormality of chromosome segregation (HP:0002916)1.84937754
99Cerebral aneurysm (HP:0004944)1.84589472
100Hypochromic microcytic anemia (HP:0004840)1.84556162
101Drooling (HP:0002307)1.84024018
102Tetraparesis (HP:0002273)1.83701010
103Pelvic girdle muscle weakness (HP:0003749)1.82686994
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.82577063
105Cutaneous melanoma (HP:0012056)1.82478596
106Urethral obstruction (HP:0000796)1.82285404
107Impulsivity (HP:0100710)1.82139969
108Broad alveolar ridges (HP:0000187)1.81967468
109Viral hepatitis (HP:0006562)1.81869134
110Cystic hygroma (HP:0000476)1.80659489
111Protruding tongue (HP:0010808)1.80570365
112Nephroblastoma (Wilms tumor) (HP:0002667)1.80456999
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.79791161
114Ankle contracture (HP:0006466)1.79129569
115Obsessive-compulsive behavior (HP:0000722)1.78930674
116Abnormality of the ileum (HP:0001549)1.78520394
117Abnormality of the left ventricular outflow tract (HP:0011103)1.78517909
118Subaortic stenosis (HP:0001682)1.78517909
119Scanning speech (HP:0002168)1.77932964
120Abnormality of the calcaneus (HP:0008364)1.75955701
121Truncal obesity (HP:0001956)1.74863758
122Tapered finger (HP:0001182)1.73966636
123Cortical dysplasia (HP:0002539)1.72965556
124Urinary urgency (HP:0000012)1.72821459
125Broad palm (HP:0001169)1.72740298
126Freckling (HP:0001480)1.72733820
127Abnormality of the corticospinal tract (HP:0002492)1.72249546
128Thick eyebrow (HP:0000574)1.72127859
129Prostate neoplasm (HP:0100787)1.71740388
130Amaurosis fugax (HP:0100576)1.71501614
131Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71109712
132Urinary bladder sphincter dysfunction (HP:0002839)1.70706538
133Embryonal renal neoplasm (HP:0011794)1.69262691
134Abnormality of the radial head (HP:0003995)1.69207137
135Spinal muscular atrophy (HP:0007269)1.68442303
136Excessive salivation (HP:0003781)1.68400660
137Submucous cleft hard palate (HP:0000176)1.68173917
138Sandal gap (HP:0001852)1.67702701
139Basal cell carcinoma (HP:0002671)1.66938076
140Neoplasm of the adrenal cortex (HP:0100641)1.66243523
141Abnormality of the epiphyses of the hand (HP:0005924)1.66092417
142Delayed puberty (HP:0000823)1.65485441
143Broad phalanges of the hand (HP:0009768)1.65140511
144Mitral valve prolapse (HP:0001634)1.64361612
145Generalized hypopigmentation of hair (HP:0011358)1.63624708
146Pulmonic stenosis (HP:0001642)1.63572574
147Abnormal auditory evoked potentials (HP:0006958)1.63566005
148Spastic paraplegia (HP:0001258)1.63204610
149Squamous cell carcinoma (HP:0002860)1.63177717
150Abnormal number of incisors (HP:0011064)1.62055274
151Germ cell neoplasia (HP:0100728)1.61388891
152Increased nuchal translucency (HP:0010880)1.61115662
153Hypoplastic ischia (HP:0003175)1.60958160
154High pitched voice (HP:0001620)1.60883273
155Abnormal hair whorl (HP:0010721)1.60719829
156Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.60653942
157Impaired vibration sensation in the lower limbs (HP:0002166)1.59159726
158Renal cell carcinoma (HP:0005584)1.58819192
159Persistence of primary teeth (HP:0006335)1.58266885
160Metaphyseal cupping (HP:0003021)1.58217485
161Anal stenosis (HP:0002025)1.57301772
162Overlapping toe (HP:0001845)1.56746584
163Gastrointestinal atresia (HP:0002589)1.56142929
164Aplasia/Hypoplasia of the sternum (HP:0006714)1.56111220
165Skull defect (HP:0001362)1.55813880
166Broad phalanx (HP:0006009)1.54916784
167Intestinal fistula (HP:0100819)1.54358623
168Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.54331995
169Cervical subluxation (HP:0003308)1.53613812
170Cafe-au-lait spot (HP:0000957)1.53139912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.74223848
2EPHA23.23583633
3LATS13.23105988
4CDK122.93774341
5WEE12.65041539
6CAMK1G2.40723852
7DDR22.21498500
8PASK2.19599934
9CAMKK22.11238926
10MAP3K21.94927914
11STK31.90705471
12RPS6KB21.89924493
13ZAK1.81932149
14NEK21.78086309
15PLK41.77299366
16TTK1.73705412
17BMPR21.69940389
18SCYL21.68262594
19CDK71.67375256
20AKT31.66720354
21ATR1.65317482
22BRSK21.64953897
23ACVR1B1.64342644
24CDK61.59003615
25MAP3K61.58551524
26CHEK21.58123597
27FRK1.54423381
28SRPK11.51875269
29PLK11.48759158
30NME21.46551764
31PLK31.46009756
32MKNK11.40389705
33AURKB1.38574237
34MAP3K141.38253029
35SGK21.35714812
36PDGFRA1.33929027
37SGK31.33092653
38DYRK31.30847439
39PIM11.29934343
40STK101.29457844
41MAP2K71.25935001
42PNCK1.24967361
43NLK1.24954630
44ERBB31.23972949
45CHEK11.22624052
46BRD41.21579061
47ATM1.19859354
48LATS21.19267696
49MELK1.18531805
50TRPM71.18393217
51EEF2K1.16438504
52STK38L1.11735231
53MAP3K41.11594409
54PKN21.10772921
55PRPF4B1.10567735
56BMX1.08620472
57WNK11.08561758
58MTOR1.07886289
59RPS6KA41.07405337
60CASK1.07187206
61NEK61.05614114
62RAF11.02190871
63TGFBR10.99925552
64BUB10.99433776
65CDK40.97636014
66MAP3K80.96934634
67TSSK60.96794286
68RET0.96407003
69CDK20.94301696
70CHUK0.92465903
71ICK0.90287762
72NEK10.90264096
73CAMKK10.90248104
74FLT30.89682549
75MKNK20.87804000
76TRIB30.83452844
77CAMK1D0.82634363
78KSR20.81725619
79MAPK150.80460417
80VRK10.80173456
81IRAK10.80131500
82FGFR10.79717886
83CLK10.78037065
84MET0.77144440
85EIF2AK20.76750699
86ALK0.76037401
87PBK0.74674462
88STK40.73461794
89NEK90.73457876
90FGFR30.72192770
91RIPK10.71288366
92CDK10.70546338
93JAK10.70121064
94ERBB40.69869077
95WNK30.67840298
96TLK10.67574255
97EIF2AK30.67234607
98BCR0.66841555
99YES10.66541920
100PAK20.64944832
101SGK4940.64837767
102SGK2230.64837767
103CDK90.64354566
104MAP3K30.64297646
105PAK60.63567325
106NUAK10.63419984
107FER0.63234980
108RPS6KB10.62989016
109SIK30.60837672
110MAPK100.60684462
111PDGFRB0.59614072
112MAP2K40.58989987
113MAPK140.58743227
114SGK10.58534371
115MARK30.58429121
116MATK0.58337377
117PAK40.57777835
118MAP3K90.56844411
119TEC0.56516274
120EIF2AK10.55563847
121KSR10.54124133
122RPS6KA50.53778669
123CAMK40.53247280
124IRAK30.52629782
125MST1R0.52422746
126GSK3A0.52380086
127DMPK0.52371421
128MAP3K110.52220776
129TTN0.51284239
130EPHA30.51258302
131CSK0.50631131
132FGR0.50543911
133STK240.48674538
134DYRK1B0.47866259
135MAP3K100.47817090
136IRAK20.47506530
137AKT10.47147007
138BMPR1B0.46566506
139MAPK10.46501847
140JAK30.46214342
141STK390.45203442
142MARK20.44024563
143STK110.43555016
144PRKAA10.42180146
145MAP3K10.40106862
146JAK20.38305958

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13161608
2Mismatch repair_Homo sapiens_hsa034303.06006540
3Cell cycle_Homo sapiens_hsa041102.90924286
4DNA replication_Homo sapiens_hsa030302.85301501
5RNA transport_Homo sapiens_hsa030132.70450392
6Base excision repair_Homo sapiens_hsa034102.22490826
7p53 signaling pathway_Homo sapiens_hsa041152.20794043
8Spliceosome_Homo sapiens_hsa030402.11164353
9Fanconi anemia pathway_Homo sapiens_hsa034601.99798177
10Systemic lupus erythematosus_Homo sapiens_hsa053221.99650497
11mRNA surveillance pathway_Homo sapiens_hsa030151.94283401
12MicroRNAs in cancer_Homo sapiens_hsa052061.86018640
13Nucleotide excision repair_Homo sapiens_hsa034201.77763858
14Homologous recombination_Homo sapiens_hsa034401.77552960
15Viral carcinogenesis_Homo sapiens_hsa052031.75033705
16One carbon pool by folate_Homo sapiens_hsa006701.73360818
17Adherens junction_Homo sapiens_hsa045201.72181148
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63888239
19TGF-beta signaling pathway_Homo sapiens_hsa043501.61778766
20RNA degradation_Homo sapiens_hsa030181.59223208
21Small cell lung cancer_Homo sapiens_hsa052221.58990172
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.56257849
23Glioma_Homo sapiens_hsa052141.54496924
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52055801
25Non-homologous end-joining_Homo sapiens_hsa034501.51513437
26Hippo signaling pathway_Homo sapiens_hsa043901.46539035
27Basal transcription factors_Homo sapiens_hsa030221.46225140
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39613769
29Long-term potentiation_Homo sapiens_hsa047201.33829193
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31812341
31Colorectal cancer_Homo sapiens_hsa052101.24367765
32mTOR signaling pathway_Homo sapiens_hsa041501.21267051
33Chronic myeloid leukemia_Homo sapiens_hsa052201.12583059
34Epstein-Barr virus infection_Homo sapiens_hsa051691.10834947
35HTLV-I infection_Homo sapiens_hsa051661.10526728
36Circadian rhythm_Homo sapiens_hsa047101.09699046
37Choline metabolism in cancer_Homo sapiens_hsa052311.08961775
38B cell receptor signaling pathway_Homo sapiens_hsa046621.08664540
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08469188
40Herpes simplex infection_Homo sapiens_hsa051681.06625065
41Antigen processing and presentation_Homo sapiens_hsa046121.06272804
42Thyroid cancer_Homo sapiens_hsa052161.06243061
43Estrogen signaling pathway_Homo sapiens_hsa049151.05993563
44Oocyte meiosis_Homo sapiens_hsa041141.05764315
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05763794
46Prostate cancer_Homo sapiens_hsa052151.02592109
47Type II diabetes mellitus_Homo sapiens_hsa049301.02534415
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01729097
49Proteoglycans in cancer_Homo sapiens_hsa052051.00178100
50Hepatitis B_Homo sapiens_hsa051610.99311190
51Notch signaling pathway_Homo sapiens_hsa043300.98472814
52GnRH signaling pathway_Homo sapiens_hsa049120.95336812
53Lysine degradation_Homo sapiens_hsa003100.92444689
54VEGF signaling pathway_Homo sapiens_hsa043700.92444256
55Alcoholism_Homo sapiens_hsa050340.91537181
56Basal cell carcinoma_Homo sapiens_hsa052170.90756324
57Insulin signaling pathway_Homo sapiens_hsa049100.89422549
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89239453
59Pancreatic cancer_Homo sapiens_hsa052120.88928748
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.87119544
61FoxO signaling pathway_Homo sapiens_hsa040680.85857505
62Endometrial cancer_Homo sapiens_hsa052130.85206535
63Focal adhesion_Homo sapiens_hsa045100.85158687
64Legionellosis_Homo sapiens_hsa051340.84948771
65Selenocompound metabolism_Homo sapiens_hsa004500.83435128
66Hedgehog signaling pathway_Homo sapiens_hsa043400.82841478
67Long-term depression_Homo sapiens_hsa047300.81271726
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81008309
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.80896976
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.79745032
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79452889
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79279873
73Bladder cancer_Homo sapiens_hsa052190.78660914
74Pathways in cancer_Homo sapiens_hsa052000.78203809
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77833716
76RNA polymerase_Homo sapiens_hsa030200.77782444
77Apoptosis_Homo sapiens_hsa042100.77111089
78ECM-receptor interaction_Homo sapiens_hsa045120.77064464
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76349599
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75194059
81Wnt signaling pathway_Homo sapiens_hsa043100.74738046
82T cell receptor signaling pathway_Homo sapiens_hsa046600.73718664
83Shigellosis_Homo sapiens_hsa051310.73041092
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72696774
85Melanoma_Homo sapiens_hsa052180.72606743
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72286399
87MAPK signaling pathway_Homo sapiens_hsa040100.70809236
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67811455
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.67778583
90Gap junction_Homo sapiens_hsa045400.66393425
91Cholinergic synapse_Homo sapiens_hsa047250.66295384
92Hepatitis C_Homo sapiens_hsa051600.65201399
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64360678
94TNF signaling pathway_Homo sapiens_hsa046680.64103088
95Tight junction_Homo sapiens_hsa045300.63875922
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63030809
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62727454
98Insulin resistance_Homo sapiens_hsa049310.62702478
99Measles_Homo sapiens_hsa051620.62649223
100Pyrimidine metabolism_Homo sapiens_hsa002400.62576530
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.62201387
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61134665
103Viral myocarditis_Homo sapiens_hsa054160.60982317
104Osteoclast differentiation_Homo sapiens_hsa043800.60710814
105Amoebiasis_Homo sapiens_hsa051460.59490775
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58943424
107Prolactin signaling pathway_Homo sapiens_hsa049170.58807576
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.58172563
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57244338
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56983686
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56887365
112Acute myeloid leukemia_Homo sapiens_hsa052210.56586884
113Fatty acid biosynthesis_Homo sapiens_hsa000610.55217711
114Non-small cell lung cancer_Homo sapiens_hsa052230.53712694
115N-Glycan biosynthesis_Homo sapiens_hsa005100.53684146
116HIF-1 signaling pathway_Homo sapiens_hsa040660.53437755
117Oxytocin signaling pathway_Homo sapiens_hsa049210.53065119
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51555084
119Dorso-ventral axis formation_Homo sapiens_hsa043200.50339625
120Toxoplasmosis_Homo sapiens_hsa051450.50272415
121Influenza A_Homo sapiens_hsa051640.47017993
122Renal cell carcinoma_Homo sapiens_hsa052110.44861718
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.43925704
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.40248969
125AMPK signaling pathway_Homo sapiens_hsa041520.39940276
126Inositol phosphate metabolism_Homo sapiens_hsa005620.38155125
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37127494
128Renin-angiotensin system_Homo sapiens_hsa046140.36179233
129Platelet activation_Homo sapiens_hsa046110.34361410
130ErbB signaling pathway_Homo sapiens_hsa040120.32593066
131Hematopoietic cell lineage_Homo sapiens_hsa046400.32264090

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