RLIMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.98559437
2protein K63-linked deubiquitination (GO:0070536)4.33911070
3signal peptide processing (GO:0006465)4.04392681
4prenylation (GO:0097354)4.03348888
5protein prenylation (GO:0018342)4.03348888
6DNA double-strand break processing (GO:0000729)3.99002526
7negative regulation of DNA-dependent DNA replication (GO:2000104)3.97087339
8monoubiquitinated protein deubiquitination (GO:0035520)3.86466855
9negative regulation of metanephros development (GO:0072217)3.84046670
10negative regulation of neurological system process (GO:0031645)3.77899795
11protein K11-linked deubiquitination (GO:0035871)3.69453651
12histone mRNA catabolic process (GO:0071044)3.68693499
13regulation of interleukin-12 biosynthetic process (GO:0045075)3.52551488
14cellular response to ethanol (GO:0071361)3.47532692
15establishment of protein localization to Golgi (GO:0072600)3.39765620
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.35219674
17regulation of energy homeostasis (GO:2000505)3.34446249
18regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.32942532
19positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.32942532
20retinal cone cell development (GO:0046549)3.30397542
21positive regulation of granulocyte differentiation (GO:0030854)3.27994158
22histone H2A acetylation (GO:0043968)3.27714847
23regulation of DNA endoreduplication (GO:0032875)3.26416394
24tachykinin receptor signaling pathway (GO:0007217)3.25561957
25positive regulation of glycolytic process (GO:0045821)3.22348060
26L-alpha-amino acid transmembrane transport (GO:1902475)3.17748409
27water-soluble vitamin biosynthetic process (GO:0042364)3.15379862
28alpha-beta T cell differentiation involved in immune response (GO:0002293)3.15330102
29alpha-beta T cell activation involved in immune response (GO:0002287)3.15330102
30T cell differentiation involved in immune response (GO:0002292)3.15330102
31protein K48-linked deubiquitination (GO:0071108)3.10107604
32regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.09693874
33replicative senescence (GO:0090399)3.07443068
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.07330794
35regulation of translation, ncRNA-mediated (GO:0045974)3.07330794
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.07330794
37positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.05061996
38protein targeting to Golgi (GO:0000042)3.00862973
39nephron tubule morphogenesis (GO:0072078)2.98015866
40nephron epithelium morphogenesis (GO:0072088)2.98015866
41DNA deamination (GO:0045006)2.96184509
42negative regulation of complement activation (GO:0045916)2.95667357
43phasic smooth muscle contraction (GO:0014821)2.93486061
44lactate metabolic process (GO:0006089)2.90681935
45regulation of hexokinase activity (GO:1903299)2.90270536
46regulation of glucokinase activity (GO:0033131)2.90270536
47sister chromatid cohesion (GO:0007062)2.84076667
48dopamine transport (GO:0015872)2.83414122
49negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82453962
50prostate gland growth (GO:0060736)2.81314791
51intestinal epithelial cell development (GO:0060576)2.81293011
52interferon-gamma production (GO:0032609)2.79104759
53atrial cardiac muscle cell action potential (GO:0086014)2.78550277
54regulation of MHC class II biosynthetic process (GO:0045346)2.78412363
55modulation of growth of symbiont involved in interaction with host (GO:0044144)2.74359423
56regulation of growth of symbiont in host (GO:0044126)2.74359423
57negative regulation of growth of symbiont in host (GO:0044130)2.74359423
58negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.74359423
59positive regulation of developmental pigmentation (GO:0048087)2.72776931
60regulation of establishment or maintenance of cell polarity (GO:0032878)2.71532258
61positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.68353219
62alpha-beta T cell differentiation (GO:0046632)2.67630551
63regulation of nuclear cell cycle DNA replication (GO:0033262)2.67119459
64double-strand break repair via homologous recombination (GO:0000724)2.66949093
65keratan sulfate catabolic process (GO:0042340)2.66346115
66regulation of interleukin-6 biosynthetic process (GO:0045408)2.63412090
67positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.62724990
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62515631
69recombinational repair (GO:0000725)2.62375452
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62071723
71retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59660249
72somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58385499
73somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58385499
74isotype switching (GO:0045190)2.58385499
75regulation of phospholipase A2 activity (GO:0032429)2.58083922
76regulation of isotype switching to IgG isotypes (GO:0048302)2.56892243
77alpha-beta T cell activation (GO:0046631)2.56240745
78regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.55095758
79valine metabolic process (GO:0006573)2.52863386
80negative regulation of protein activation cascade (GO:2000258)2.52766722
81renal tubule morphogenesis (GO:0061333)2.50659816
82regulation of establishment of cell polarity (GO:2000114)2.50407046
83regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.47604529
84regulation of protein glycosylation (GO:0060049)2.47433666
85leukotriene biosynthetic process (GO:0019370)2.46157707
86bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44739650
87mitochondrial DNA replication (GO:0006264)2.43801210
88respiratory chain complex IV assembly (GO:0008535)2.43509774
89regulation of pigment cell differentiation (GO:0050932)2.42223621
90negative regulation of cAMP-mediated signaling (GO:0043951)2.41824594
91telomere maintenance via telomerase (GO:0007004)2.41331567
92protein K6-linked ubiquitination (GO:0085020)2.40605695
93regulation of meiosis I (GO:0060631)2.40352295
94embryonic hemopoiesis (GO:0035162)2.40133842
95magnesium ion transport (GO:0015693)2.36038868
96positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.35898109
97definitive hemopoiesis (GO:0060216)2.35737909
98negative regulation of execution phase of apoptosis (GO:1900118)2.34150471
99pteridine-containing compound biosynthetic process (GO:0042559)2.33801529
100pericardium development (GO:0060039)2.33505545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.62804130
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51612339
3GATA1_22025678_ChIP-Seq_K562_Human3.20919230
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.98560214
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.80267461
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.70154417
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47242008
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46535933
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44991091
10ZNF274_21170338_ChIP-Seq_K562_Hela2.39461725
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.33460978
12GBX2_23144817_ChIP-Seq_PC3_Human2.15661844
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05899651
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05647655
15VDR_22108803_ChIP-Seq_LS180_Human1.99354609
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97476204
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94424966
18P300_19829295_ChIP-Seq_ESCs_Human1.92994374
19IGF1R_20145208_ChIP-Seq_DFB_Human1.91073180
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91068502
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84281619
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.83787193
23FUS_26573619_Chip-Seq_HEK293_Human1.81824499
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.81242739
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.78264358
26EWS_26573619_Chip-Seq_HEK293_Human1.75742855
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75361739
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73749224
29TAF15_26573619_Chip-Seq_HEK293_Human1.69209828
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.66803784
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63166767
32CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.61484771
33BCAT_22108803_ChIP-Seq_LS180_Human1.61143047
34ER_23166858_ChIP-Seq_MCF-7_Human1.59251525
35SMAD4_21799915_ChIP-Seq_A2780_Human1.57456820
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52530593
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.51621466
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49935666
39STAT3_23295773_ChIP-Seq_U87_Human1.48479941
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45801001
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.41458641
42CRX_20693478_ChIP-Seq_RETINA_Mouse1.41435979
43TCF4_23295773_ChIP-Seq_U87_Human1.41200960
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40921091
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40140632
46RUNX_20019798_ChIP-Seq_JUKART_Human1.39054908
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38342641
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34572665
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34034076
50CBP_20019798_ChIP-Seq_JUKART_Human1.34034076
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.32832447
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31548807
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.30324069
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29672940
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29672940
56CDX2_22108803_ChIP-Seq_LS180_Human1.29005957
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28800485
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28792548
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28574934
60OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28166094
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.25969272
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.25556289
63SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25171357
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25116819
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22808542
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20479497
67P53_22387025_ChIP-Seq_ESCs_Mouse1.18843363
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18316753
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18158904
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.18029928
71P300_18555785_Chip-Seq_ESCs_Mouse1.17291030
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17035983
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.15521192
74ELK1_19687146_ChIP-ChIP_HELA_Human1.14922788
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14570079
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14163236
77AR_25329375_ChIP-Seq_VCAP_Human1.14152392
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14067905
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.13922406
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12872254
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.12477249
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12416295
83TP53_16413492_ChIP-PET_HCT116_Human1.11235053
84TCF4_22108803_ChIP-Seq_LS180_Human1.11077464
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10703786
86VDR_23849224_ChIP-Seq_CD4+_Human1.10431661
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.10021408
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09989595
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07947458
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.07919431
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.07631967
92NANOG_19829295_ChIP-Seq_ESCs_Human1.07438605
93SOX2_19829295_ChIP-Seq_ESCs_Human1.07438605
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.06518205
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06335183
96RUNX2_22187159_ChIP-Seq_PCA_Human1.06150875
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04149129
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.03741911
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02937123
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01751143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.77002419
2MP0003195_calcinosis4.36716343
3MP0006054_spinal_hemorrhage3.25262601
4MP0002254_reproductive_system_inflammat2.77908606
5MP0000569_abnormal_digit_pigmentation2.69529084
6MP0008877_abnormal_DNA_methylation2.68831157
7MP0002837_dystrophic_cardiac_calcinosis2.50856636
8MP0003763_abnormal_thymus_physiology2.32076148
9MP0003890_abnormal_embryonic-extraembry2.12325343
10MP0003646_muscle_fatigue2.08418095
11MP0002138_abnormal_hepatobiliary_system2.02976438
12MP0005275_abnormal_skin_tensile1.97922744
13MP0001873_stomach_inflammation1.89333809
14MP0005379_endocrine/exocrine_gland_phen1.85990168
15MP0005075_abnormal_melanosome_morpholog1.80027056
16MP0001835_abnormal_antigen_presentation1.75425561
17MP0004215_abnormal_myocardial_fiber1.74532324
18MP0005670_abnormal_white_adipose1.74288835
19MP0002139_abnormal_hepatobiliary_system1.71520492
20MP0000427_abnormal_hair_cycle1.67644849
21MP0002166_altered_tumor_susceptibility1.58759436
22MP0001661_extended_life_span1.56842591
23MP0005503_abnormal_tendon_morphology1.55380211
24MP0005084_abnormal_gallbladder_morpholo1.55034038
25MP0003786_premature_aging1.54571337
26MP0010307_abnormal_tumor_latency1.53948811
27MP0006072_abnormal_retinal_apoptosis1.50680084
28MP0003787_abnormal_imprinting1.48312742
29MP0001501_abnormal_sleep_pattern1.48157251
30MP0005551_abnormal_eye_electrophysiolog1.35260896
31MP0000383_abnormal_hair_follicle1.34260376
32MP0002168_other_aberrant_phenotype1.26946392
33MP0002876_abnormal_thyroid_physiology1.26918411
34MP0003172_abnormal_lysosome_physiology1.24951623
35MP0002332_abnormal_exercise_endurance1.23185519
36MP0008058_abnormal_DNA_repair1.18773478
37MP0002006_tumorigenesis1.17273356
38MP0001800_abnormal_humoral_immune1.16898694
39MP0005671_abnormal_response_to1.16798070
40MP0005253_abnormal_eye_physiology1.16642095
41MP0008995_early_reproductive_senescence1.10954578
42MP0005310_abnormal_salivary_gland1.10679754
43MP0002405_respiratory_system_inflammati1.10208742
44MP0000013_abnormal_adipose_tissue1.08998911
45MP0010386_abnormal_urinary_bladder1.08891562
46MP0002396_abnormal_hematopoietic_system1.08875870
47MP0005266_abnormal_metabolism1.08241721
48MP0009785_altered_susceptibility_to1.08073316
49MP0004782_abnormal_surfactant_physiolog1.06779538
50MP0010094_abnormal_chromosome_stability1.03396525
51MP0002933_joint_inflammation1.01261097
52MP0004808_abnormal_hematopoietic_stem1.01156837
53MP0002693_abnormal_pancreas_physiology1.00680889
54MP0003045_fibrosis0.99502121
55MP0004484_altered_response_of0.98885106
56MP0005389_reproductive_system_phenotype0.98791982
57MP0000685_abnormal_immune_system0.96828248
58MP0000689_abnormal_spleen_morphology0.94841432
59MP0002638_abnormal_pupillary_reflex0.94396789
60MP0004085_abnormal_heartbeat0.91859039
61MP0010329_abnormal_lipoprotein_level0.91298089
62MP0004130_abnormal_muscle_cell0.91140827
63MP0003121_genomic_imprinting0.91014342
64MP0001790_abnormal_immune_system0.87956304
65MP0005387_immune_system_phenotype0.87956304
66MP0009115_abnormal_fat_cell0.86940975
67MP0003186_abnormal_redox_activity0.86485547
68MP0001666_abnormal_nutrient_absorption0.85019546
69MP0005174_abnormal_tail_pigmentation0.84537265
70MP0000703_abnormal_thymus_morphology0.83435664
71MP0001984_abnormal_olfaction0.81343446
72MP0001944_abnormal_pancreas_morphology0.81185108
73MP0002078_abnormal_glucose_homeostasis0.79477750
74MP0005448_abnormal_energy_balance0.79126207
75MP0005395_other_phenotype0.78683147
76MP0001986_abnormal_taste_sensitivity0.77869786
77MP0009764_decreased_sensitivity_to0.77807130
78MP0002928_abnormal_bile_duct0.77273012
79MP0002163_abnormal_gland_morphology0.77182537
80MP0005408_hypopigmentation0.75713045
81MP0008872_abnormal_physiological_respon0.74390146
82MP0008775_abnormal_heart_ventricle0.73835210
83MP0003633_abnormal_nervous_system0.72743491
84MP0005332_abnormal_amino_acid0.71098162
85MP0010678_abnormal_skin_adnexa0.71065631
86MP0005220_abnormal_exocrine_pancreas0.70556777
87MP0001853_heart_inflammation0.65473454
88MP0009333_abnormal_splenocyte_physiolog0.64795652
89MP0002277_abnormal_respiratory_mucosa0.64752144
90MP0002160_abnormal_reproductive_system0.64001865
91MP0001177_atelectasis0.63199085
92MP0002102_abnormal_ear_morphology0.62368664
93MP0000015_abnormal_ear_pigmentation0.61246382
94MP0004084_abnormal_cardiac_muscle0.61231879
95MP0000230_abnormal_systemic_arterial0.61222609
96MP0000516_abnormal_urinary_system0.60912924
97MP0005367_renal/urinary_system_phenotyp0.60912924
98MP0000372_irregular_coat_pigmentation0.59349318
99MP0004381_abnormal_hair_follicle0.59228648
100MP0005645_abnormal_hypothalamus_physiol0.58412482

Predicted human phenotypes

RankGene SetZ-score
1Thyroiditis (HP:0100646)4.75001587
2Volvulus (HP:0002580)3.66657711
3Gaze-evoked nystagmus (HP:0000640)3.43414984
4Glucose intolerance (HP:0000833)3.38467686
5Stomatitis (HP:0010280)3.20125683
6Pancreatic cysts (HP:0001737)2.97892440
7Abnormality of the renal cortex (HP:0011035)2.78278873
8Abnormal glucose tolerance (HP:0001952)2.77057982
9Abnormality of vitamin B metabolism (HP:0004340)2.75353157
10T lymphocytopenia (HP:0005403)2.72002329
11Severe combined immunodeficiency (HP:0004430)2.69586796
12Methylmalonic acidemia (HP:0002912)2.60199551
13Hypoproteinemia (HP:0003075)2.59574220
14Abolished electroretinogram (ERG) (HP:0000550)2.59078962
15Abnormality of B cell number (HP:0010975)2.55792503
16Rhabdomyosarcoma (HP:0002859)2.55510269
17Progressive inability to walk (HP:0002505)2.52077295
18Recurrent bronchitis (HP:0002837)2.50687399
19Abnormality of T cell number (HP:0011839)2.50269248
20Facial diplegia (HP:0001349)2.46308292
21IgG deficiency (HP:0004315)2.44821423
22True hermaphroditism (HP:0010459)2.43363602
23Hypoglycemic coma (HP:0001325)2.39272070
24Abnormality of urine glucose concentration (HP:0011016)2.36486351
25Glycosuria (HP:0003076)2.36486351
26Methylmalonic aciduria (HP:0012120)2.35631560
27Exertional dyspnea (HP:0002875)2.34836869
28Abnormal pancreas size (HP:0012094)2.33912361
29B lymphocytopenia (HP:0010976)2.32734177
30Abnormality of the vitamin B12 metabolism (HP:0004341)2.30277357
31Renal cortical cysts (HP:0000803)2.30012225
32Pancreatic islet-cell hyperplasia (HP:0004510)2.29560140
33Pancreatic fibrosis (HP:0100732)2.29440093
34Hyperglycemia (HP:0003074)2.26035297
35Congenital, generalized hypertrichosis (HP:0004540)2.26032678
36Abnormality of midbrain morphology (HP:0002418)2.23515198
37Molar tooth sign on MRI (HP:0002419)2.23515198
38Hypoplasia of the thymus (HP:0000778)2.23086748
39Fair hair (HP:0002286)2.22678850
40Hematochezia (HP:0002573)2.21884328
41Conjunctival hamartoma (HP:0100780)2.20336817
42Inability to walk (HP:0002540)2.15754316
43Hyperkalemia (HP:0002153)2.12449611
44Hyperinsulinemic hypoglycemia (HP:0000825)2.11780585
45Furrowed tongue (HP:0000221)2.05987434
46Abnormality of eosinophils (HP:0001879)2.05046768
47Conjunctival telangiectasia (HP:0000524)2.03160896
48Prominent nose (HP:0000448)2.03046883
49Hypoglycemic seizures (HP:0002173)2.02132175
50Carpal bone hypoplasia (HP:0001498)2.01010155
51Large for gestational age (HP:0001520)2.00119111
52Aplasia/Hypoplasia of the tibia (HP:0005772)1.99797478
53Hamartoma of the eye (HP:0010568)1.99301952
54Elevated erythrocyte sedimentation rate (HP:0003565)1.98743745
55Combined immunodeficiency (HP:0005387)1.97666589
56Genetic anticipation (HP:0003743)1.94649670
57Abnormal biliary tract physiology (HP:0012439)1.92092145
58Bile duct proliferation (HP:0001408)1.92092145
59Widely spaced teeth (HP:0000687)1.90892517
60Absent frontal sinuses (HP:0002688)1.89961381
61Attenuation of retinal blood vessels (HP:0007843)1.88409269
62Small hand (HP:0200055)1.88384137
63Neoplasm of the adrenal gland (HP:0100631)1.87600218
64Congenital stationary night blindness (HP:0007642)1.87337986
65Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87087647
66Chronic hepatic failure (HP:0100626)1.86901318
67Pigmentary retinal degeneration (HP:0001146)1.86130093
68Abnormality of methionine metabolism (HP:0010901)1.85572632
69Ketoacidosis (HP:0001993)1.84826321
70Acute myeloid leukemia (HP:0004808)1.84213054
71Abnormality of the renal medulla (HP:0100957)1.84160404
72Gonadal dysgenesis (HP:0000133)1.82550756
73Tubular atrophy (HP:0000092)1.82415905
74Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80499615
75Palpitations (HP:0001962)1.78990116
76Popliteal pterygium (HP:0009756)1.78499374
77Abnormal drinking behavior (HP:0030082)1.77345224
78Polydipsia (HP:0001959)1.77345224
79Hypothermia (HP:0002045)1.77067666
80Aqueductal stenosis (HP:0002410)1.75505498
81Stomach cancer (HP:0012126)1.74803970
82Delayed closure of the anterior fontanelle (HP:0001476)1.74708687
83Meningioma (HP:0002858)1.74543353
84Neoplasm of the adrenal cortex (HP:0100641)1.74420373
85Male pseudohermaphroditism (HP:0000037)1.73658537
86Abnormality of vitamin metabolism (HP:0100508)1.73138137
87Delayed puberty (HP:0000823)1.72697385
88Abnormality of chromosome stability (HP:0003220)1.70950939
89Hypochromic microcytic anemia (HP:0004840)1.70698070
90Recurrent fungal infections (HP:0002841)1.70539135
91Nephroblastoma (Wilms tumor) (HP:0002667)1.69912968
92Abnormality of the nasal septum (HP:0000419)1.69657130
93Embryonal renal neoplasm (HP:0011794)1.69418575
94Eosinophilia (HP:0001880)1.69050816
95Hypokalemic alkalosis (HP:0001949)1.66359083
96Neoplasm of striated muscle (HP:0009728)1.66057117
97Prominent metopic ridge (HP:0005487)1.65970435
98IgA deficiency (HP:0002720)1.65136023
99Abnormality of the pancreatic islet cells (HP:0006476)1.64375178
100Abnormality of endocrine pancreas physiology (HP:0012093)1.64375178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.31817245
2NLK3.51300217
3MST42.69326113
4BMPR1B2.48459641
5NUAK12.42590015
6ACVR1B2.39880695
7TXK2.31919268
8TSSK62.20695942
9MKNK22.11819261
10TIE11.89570747
11BRSK21.86826164
12ADRBK21.81856655
13EIF2AK31.80144116
14PDK21.74272579
15TEC1.63879428
16FGFR31.59882695
17WNK31.58286901
18SGK21.52541234
19CAMKK21.51439844
20IRAK11.50724655
21PLK21.50397020
22MAP2K61.50310978
23BLK1.47974516
24FGFR21.41682416
25PLK31.38112565
26STK161.31327374
27PTK2B1.28429118
28ZAK1.25059505
29GRK11.21798728
30PAK31.21287451
31IKBKE1.20992090
32PNCK1.19847790
33FER1.10897355
34CAMK1G1.10247889
35STK41.09327394
36OXSR11.08100085
37STK391.03920363
38WNK10.99584919
39ITK0.98604859
40TRIM280.98310438
41PIK3CA0.97134698
42STK38L0.95327902
43TAOK30.92279644
44AKT30.91626997
45MKNK10.89211112
46FGFR10.88031392
47MAP4K20.86969639
48TNK20.86821116
49OBSCN0.83995759
50MELK0.83202148
51STK30.80653812
52PIK3CG0.79940685
53NEK60.75043129
54TGFBR10.74691755
55SGK4940.74016415
56SGK2230.74016415
57IKBKB0.71893032
58ADRBK10.71763318
59CSNK1G10.71676599
60TRPM70.69752663
61PRKAA20.69425992
62PLK40.69208757
63JAK10.67563112
64SGK30.67330672
65MAP3K70.62003749
66BRD40.61168909
67MAP3K40.59615434
68TNIK0.59390408
69CLK10.58436265
70CAMK1D0.56750712
71STK110.55716609
72TGFBR20.55390636
73PRKCE0.55305360
74BTK0.54992958
75MAP4K10.52685340
76EIF2AK20.48370511
77STK240.48207071
78GRK50.47924392
79PINK10.47365565
80STK100.47030678
81TTK0.45824219
82ATR0.45361879
83FGR0.44638738
84MYLK0.43646135
85CAMK40.42565360
86LCK0.42211191
87ATM0.41821071
88MAPK130.41098011
89MAP3K120.39455394
90NME10.38752531
91SGK10.38687388
92WNK40.38007629
93SYK0.37975280
94DYRK1A0.37471194
95ERBB40.36978874
96JAK30.35850104
97CHUK0.33813295
98DAPK20.33071910
99CAMK10.32731988
100IRAK20.32202446

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.86453073
2Protein export_Homo sapiens_hsa030603.15943466
3Propanoate metabolism_Homo sapiens_hsa006403.09017252
4Non-homologous end-joining_Homo sapiens_hsa034502.91142332
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.74264331
6Homologous recombination_Homo sapiens_hsa034402.38150245
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35845185
8Regulation of autophagy_Homo sapiens_hsa041402.29281779
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.17267210
10One carbon pool by folate_Homo sapiens_hsa006702.11802110
11Circadian rhythm_Homo sapiens_hsa047101.93075034
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89358268
13Linoleic acid metabolism_Homo sapiens_hsa005911.83924452
14Selenocompound metabolism_Homo sapiens_hsa004501.73425827
15RNA degradation_Homo sapiens_hsa030181.69816858
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66338807
17ABC transporters_Homo sapiens_hsa020101.54343438
18Tryptophan metabolism_Homo sapiens_hsa003801.47424691
19Phototransduction_Homo sapiens_hsa047441.46808707
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43378986
21Primary immunodeficiency_Homo sapiens_hsa053401.39510571
22Collecting duct acid secretion_Homo sapiens_hsa049661.28279653
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26837165
24Type I diabetes mellitus_Homo sapiens_hsa049401.24053435
25Butanoate metabolism_Homo sapiens_hsa006501.23633339
26RNA polymerase_Homo sapiens_hsa030201.22881359
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18517189
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14055123
29T cell receptor signaling pathway_Homo sapiens_hsa046601.13702868
30Caffeine metabolism_Homo sapiens_hsa002321.12627923
31Ether lipid metabolism_Homo sapiens_hsa005651.12407706
32Fanconi anemia pathway_Homo sapiens_hsa034601.11557918
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06283647
34beta-Alanine metabolism_Homo sapiens_hsa004101.06239798
35Glycerolipid metabolism_Homo sapiens_hsa005611.01985171
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01535943
37Insulin resistance_Homo sapiens_hsa049311.01364205
38Basal transcription factors_Homo sapiens_hsa030221.00710351
39Dorso-ventral axis formation_Homo sapiens_hsa043200.98305415
40Jak-STAT signaling pathway_Homo sapiens_hsa046300.97462655
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.91871798
42Taste transduction_Homo sapiens_hsa047420.91591553
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90254778
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88792203
45Retinol metabolism_Homo sapiens_hsa008300.87417756
46Arachidonic acid metabolism_Homo sapiens_hsa005900.85399818
47TGF-beta signaling pathway_Homo sapiens_hsa043500.84490700
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83557441
49Renin-angiotensin system_Homo sapiens_hsa046140.82845852
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81305894
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80801188
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80071522
53Peroxisome_Homo sapiens_hsa041460.79466617
54Fatty acid degradation_Homo sapiens_hsa000710.78905485
55Purine metabolism_Homo sapiens_hsa002300.77281014
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76461342
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76299844
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74282487
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73153117
60FoxO signaling pathway_Homo sapiens_hsa040680.71729647
61Fat digestion and absorption_Homo sapiens_hsa049750.67747173
62Nitrogen metabolism_Homo sapiens_hsa009100.66920208
63Measles_Homo sapiens_hsa051620.65746857
64mTOR signaling pathway_Homo sapiens_hsa041500.65096462
65Malaria_Homo sapiens_hsa051440.63275368
66Histidine metabolism_Homo sapiens_hsa003400.62177549
67Lysine degradation_Homo sapiens_hsa003100.60856595
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60319805
69Oxidative phosphorylation_Homo sapiens_hsa001900.59951447
70Fatty acid elongation_Homo sapiens_hsa000620.59769083
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.59647428
72Hematopoietic cell lineage_Homo sapiens_hsa046400.58746673
73Ovarian steroidogenesis_Homo sapiens_hsa049130.58098376
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55924325
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.54468879
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54251189
77Rheumatoid arthritis_Homo sapiens_hsa053230.54035178
78Platelet activation_Homo sapiens_hsa046110.53638589
79Calcium signaling pathway_Homo sapiens_hsa040200.51113596
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48006400
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.48001382
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.47542245
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45978270
84Pancreatic secretion_Homo sapiens_hsa049720.45647733
85Mismatch repair_Homo sapiens_hsa034300.45579451
86Sulfur metabolism_Homo sapiens_hsa009200.43726604
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43617802
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42552411
89Chemical carcinogenesis_Homo sapiens_hsa052040.42252135
90Fatty acid metabolism_Homo sapiens_hsa012120.40791799
91Renin secretion_Homo sapiens_hsa049240.40397927
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.39228920
93Glucagon signaling pathway_Homo sapiens_hsa049220.38431468
94Mineral absorption_Homo sapiens_hsa049780.37747680
95Vitamin B6 metabolism_Homo sapiens_hsa007500.37420647
96PPAR signaling pathway_Homo sapiens_hsa033200.37236003
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.36983867
98African trypanosomiasis_Homo sapiens_hsa051430.35424491
99Insulin secretion_Homo sapiens_hsa049110.34510319
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34264029

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