RLIMP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.82711128
2retinal cone cell development (GO:0046549)5.14483588
3limb bud formation (GO:0060174)5.04740334
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.01587614
5glial cell proliferation (GO:0014009)4.66765344
6epithelial cilium movement (GO:0003351)4.52760992
7histone H2A acetylation (GO:0043968)4.45287860
8DNA double-strand break processing (GO:0000729)4.34483218
9somite rostral/caudal axis specification (GO:0032525)4.34390420
10protein prenylation (GO:0018342)4.27538376
11prenylation (GO:0097354)4.27538376
12forebrain neuron differentiation (GO:0021879)4.25716408
13regulation of hexokinase activity (GO:1903299)4.24766376
14regulation of glucokinase activity (GO:0033131)4.24766376
15positive regulation of vasculogenesis (GO:2001214)4.23668628
16synaptic transmission, cholinergic (GO:0007271)4.21203740
17cellular response to cholesterol (GO:0071397)4.17670397
18pyrimidine nucleobase catabolic process (GO:0006208)3.95738389
19mitotic sister chromatid cohesion (GO:0007064)3.94161944
20negative regulation of vascular permeability (GO:0043116)3.87829816
21regulation of DNA endoreduplication (GO:0032875)3.87137936
22resolution of meiotic recombination intermediates (GO:0000712)3.85431464
23cellular response to sterol (GO:0036315)3.83925298
24kinetochore organization (GO:0051383)3.81547998
25neural tube formation (GO:0001841)3.77611508
26primitive streak formation (GO:0090009)3.69167165
27sympathetic nervous system development (GO:0048485)3.64610384
28centriole replication (GO:0007099)3.44981281
29platelet dense granule organization (GO:0060155)3.44139171
30presynaptic membrane organization (GO:0097090)3.40393929
31lactate metabolic process (GO:0006089)3.35117064
32cilium movement (GO:0003341)3.32799963
33replication fork processing (GO:0031297)3.31691227
34developmental pigmentation (GO:0048066)3.30392825
35presynaptic membrane assembly (GO:0097105)3.21348163
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17463714
37regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.14949263
38positive regulation of gastrulation (GO:2000543)3.14722272
39protein-cofactor linkage (GO:0018065)3.12940303
40aldehyde catabolic process (GO:0046185)3.11674451
41ganglion development (GO:0061548)3.10550393
42cardiac septum development (GO:0003279)3.09787853
43regulation of collateral sprouting (GO:0048670)3.08894478
44negative regulation of telomere maintenance (GO:0032205)3.06055517
45neuron fate specification (GO:0048665)3.05622668
46spinal cord development (GO:0021510)3.05054474
47DNA ligation (GO:0006266)3.04900670
48inner ear receptor stereocilium organization (GO:0060122)3.03771367
49response to folic acid (GO:0051593)3.03735448
50DNA demethylation (GO:0080111)3.03646840
51cellular response to ATP (GO:0071318)3.03466967
52regulation of non-canonical Wnt signaling pathway (GO:2000050)3.03080190
53kidney morphogenesis (GO:0060993)3.02606720
54kinetochore assembly (GO:0051382)3.02313834
55regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.99955298
56nucleobase catabolic process (GO:0046113)2.99910467
57cardiac ventricle formation (GO:0003211)2.99322642
58prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.96149478
59regulation of timing of cell differentiation (GO:0048505)2.96120215
60basement membrane organization (GO:0071711)2.91766384
61ventricular system development (GO:0021591)2.91596272
62sequestering of actin monomers (GO:0042989)2.91214357
63somite development (GO:0061053)2.89197477
64cornea development in camera-type eye (GO:0061303)2.85501456
65regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:22.83819529
66epithelial cell differentiation involved in kidney development (GO:0035850)2.83105000
67carnitine metabolic process (GO:0009437)2.82788709
68regulation of vasculogenesis (GO:2001212)2.80166295
69establishment of integrated proviral latency (GO:0075713)2.78297480
70retinal ganglion cell axon guidance (GO:0031290)2.76783483
71mechanoreceptor differentiation (GO:0042490)2.74536211
72centriole assembly (GO:0098534)2.74310063
73cardiac chamber formation (GO:0003207)2.73435358
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73261407
75negative regulation of translation, ncRNA-mediated (GO:0040033)2.73261407
76regulation of translation, ncRNA-mediated (GO:0045974)2.73261407
77dopaminergic neuron differentiation (GO:0071542)2.72772218
78behavioral response to ethanol (GO:0048149)2.72369495
79cerebral cortex radially oriented cell migration (GO:0021799)2.68652725
80inner ear receptor cell differentiation (GO:0060113)2.67876061
81peptidyl-histidine modification (GO:0018202)2.66793757
82postsynaptic membrane organization (GO:0001941)2.65892566
83regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.65720271
84transmission of nerve impulse (GO:0019226)2.64565867
85neuromuscular synaptic transmission (GO:0007274)2.62358876
86DNA integration (GO:0015074)2.60281790
87regulation of development, heterochronic (GO:0040034)2.59917222
88spinal cord association neuron differentiation (GO:0021527)2.58813271
89chromatin remodeling at centromere (GO:0031055)2.58690880
90cAMP biosynthetic process (GO:0006171)2.58536164
91protein polyglutamylation (GO:0018095)2.57437746
92inner mitochondrial membrane organization (GO:0007007)2.55804768
93neuron cell-cell adhesion (GO:0007158)2.55125433
94eye photoreceptor cell development (GO:0042462)2.54724392
95response to cholesterol (GO:0070723)2.54118877
96sister chromatid cohesion (GO:0007062)2.52400672
97double-strand break repair via homologous recombination (GO:0000724)2.52187668
98response to sterol (GO:0036314)2.51976832
99dentate gyrus development (GO:0021542)2.50696690
100microtubule depolymerization (GO:0007019)2.50618176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.61222198
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.41786145
3IGF1R_20145208_ChIP-Seq_DFB_Human3.11038744
4EZH2_22144423_ChIP-Seq_EOC_Human2.95782405
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94518117
6VDR_22108803_ChIP-Seq_LS180_Human2.89068385
7ZNF274_21170338_ChIP-Seq_K562_Hela2.72065066
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70955768
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.70955768
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59259321
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.58236885
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55356584
13EWS_26573619_Chip-Seq_HEK293_Human2.42538021
14POU5F1_16153702_ChIP-ChIP_HESCs_Human2.36223056
15GBX2_23144817_ChIP-Seq_PC3_Human2.34084542
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.32836927
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30972238
18TAF15_26573619_Chip-Seq_HEK293_Human2.26600885
19P300_19829295_ChIP-Seq_ESCs_Human2.22793190
20FUS_26573619_Chip-Seq_HEK293_Human2.18277751
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18257312
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.04893883
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03997740
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.94261981
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.92991831
26BCAT_22108803_ChIP-Seq_LS180_Human1.89294031
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79306263
28ER_23166858_ChIP-Seq_MCF-7_Human1.78533246
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76160302
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74411349
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64727600
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59420499
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.59296188
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57257295
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.56202401
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.55468598
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51783032
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51509305
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.50528927
40ELK1_19687146_ChIP-ChIP_HELA_Human1.48820809
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45389352
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39912148
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38614515
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37689151
45SMAD4_21799915_ChIP-Seq_A2780_Human1.36285467
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35425946
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32954920
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32510663
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32034619
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31941728
51AR_25329375_ChIP-Seq_VCAP_Human1.31194839
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31068000
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.30474371
54RNF2_27304074_Chip-Seq_NSC_Mouse1.29548675
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29268161
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26720237
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25474916
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24628601
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.23833975
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23550789
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22975950
62IRF1_19129219_ChIP-ChIP_H3396_Human1.21589562
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.20031853
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.19883340
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19819591
66TP53_22573176_ChIP-Seq_HFKS_Human1.16344560
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.16153877
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15416049
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14996172
70CBP_20019798_ChIP-Seq_JUKART_Human1.14996172
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13543249
72RUNX2_22187159_ChIP-Seq_PCA_Human1.11753741
73STAT3_23295773_ChIP-Seq_U87_Human1.10850755
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10328653
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10232418
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09958476
77P53_22387025_ChIP-Seq_ESCs_Mouse1.09936252
78TCF4_23295773_ChIP-Seq_U87_Human1.09879789
79REST_21632747_ChIP-Seq_MESCs_Mouse1.07229939
80NANOG_19829295_ChIP-Seq_ESCs_Human1.06496803
81SOX2_19829295_ChIP-Seq_ESCs_Human1.06496803
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05365173
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.04940730
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03856682
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03435414
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03347624
87TCF4_22108803_ChIP-Seq_LS180_Human1.02789892
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02676165
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02365756
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01981597
91SOX9_26525672_Chip-Seq_HEART_Mouse1.01334820
92VDR_23849224_ChIP-Seq_CD4+_Human0.97888215
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97850106
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97730051
95RXR_22108803_ChIP-Seq_LS180_Human0.97459605
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97160567
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96778849
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.96560011
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96205927
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95660782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex4.47201232
2MP0002822_catalepsy4.05959797
3MP0005171_absent_coat_pigmentation3.47721135
4MP0005646_abnormal_pituitary_gland3.09734481
5MP0010386_abnormal_urinary_bladder3.00754452
6MP0008961_abnormal_basal_metabolism2.97784776
7MP0009379_abnormal_foot_pigmentation2.85984909
8MP0005167_abnormal_blood-brain_barrier2.76699378
9MP0003880_abnormal_central_pattern2.69060697
10MP0005187_abnormal_penis_morphology2.45489498
11MP0002938_white_spotting2.38532045
12MP0002751_abnormal_autonomic_nervous2.36683778
13MP0000778_abnormal_nervous_system2.21075167
14MP0000372_irregular_coat_pigmentation2.19610185
15MP0008789_abnormal_olfactory_epithelium2.16744622
16MP0010030_abnormal_orbit_morphology2.14310695
17MP0001485_abnormal_pinna_reflex2.12074441
18MP0002653_abnormal_ependyma_morphology2.05830090
19MP0006072_abnormal_retinal_apoptosis1.94733588
20MP0003890_abnormal_embryonic-extraembry1.93017161
21MP0003121_genomic_imprinting1.84661737
22MP0005394_taste/olfaction_phenotype1.84302901
23MP0005499_abnormal_olfactory_system1.84302901
24MP0001529_abnormal_vocalization1.83248630
25MP0002282_abnormal_trachea_morphology1.81915223
26MP0000538_abnormal_urinary_bladder1.79732487
27MP0003718_maternal_effect1.73712384
28MP0000383_abnormal_hair_follicle1.69546072
29MP0004133_heterotaxia1.60202395
30MP0008058_abnormal_DNA_repair1.57927024
31MP0004043_abnormal_pH_regulation1.57783160
32MP0000647_abnormal_sebaceous_gland1.56283386
33MP0005253_abnormal_eye_physiology1.54497047
34MP0000427_abnormal_hair_cycle1.52498352
35MP0006292_abnormal_olfactory_placode1.48890772
36MP0005551_abnormal_eye_electrophysiolog1.47317365
37MP0005248_abnormal_Harderian_gland1.46640479
38MP0000049_abnormal_middle_ear1.46172458
39MP0003136_yellow_coat_color1.46002229
40MP0008995_early_reproductive_senescence1.42519834
41MP0004885_abnormal_endolymph1.38557815
42MP0002736_abnormal_nociception_after1.34267103
43MP0001486_abnormal_startle_reflex1.32818232
44MP0000631_abnormal_neuroendocrine_gland1.32477427
45MP0002277_abnormal_respiratory_mucosa1.29582183
46MP0005083_abnormal_biliary_tract1.27500813
47MP0004147_increased_porphyrin_level1.26448290
48MP0001346_abnormal_lacrimal_gland1.25926155
49MP0008877_abnormal_DNA_methylation1.25783710
50MP0003938_abnormal_ear_development1.24076504
51MP0005386_behavior/neurological_phenoty1.16725929
52MP0004924_abnormal_behavior1.16725929
53MP0003122_maternal_imprinting1.14120580
54MP0000026_abnormal_inner_ear1.12785176
55MP0003787_abnormal_imprinting1.12322699
56MP0009745_abnormal_behavioral_response1.09641603
57MP0003937_abnormal_limbs/digits/tail_de1.07814072
58MP0004742_abnormal_vestibular_system1.07135743
59MP0002233_abnormal_nose_morphology1.06762760
60MP0002752_abnormal_somatic_nervous1.06348060
61MP0002184_abnormal_innervation1.03244866
62MP0005391_vision/eye_phenotype1.02919462
63MP0001879_abnormal_lymphatic_vessel1.01917730
64MP0008057_abnormal_DNA_replication0.98992294
65MP0005409_darkened_coat_color0.98924295
66MP0003861_abnormal_nervous_system0.96544710
67MP0008004_abnormal_stomach_pH0.94838613
68MP0001968_abnormal_touch/_nociception0.94524112
69MP0002102_abnormal_ear_morphology0.93118297
70MP0001501_abnormal_sleep_pattern0.93072324
71MP0001286_abnormal_eye_development0.91704743
72MP0004145_abnormal_muscle_electrophysio0.89631033
73MP0000955_abnormal_spinal_cord0.89578780
74MP0008875_abnormal_xenobiotic_pharmacok0.88495351
75MP0002557_abnormal_social/conspecific_i0.87002124
76MP0002095_abnormal_skin_pigmentation0.85627725
77MP0001963_abnormal_hearing_physiology0.85618338
78MP0000534_abnormal_ureter_morphology0.85192171
79MP0010678_abnormal_skin_adnexa0.82899613
80MP0003755_abnormal_palate_morphology0.82675963
81MP0002272_abnormal_nervous_system0.82607769
82MP0002111_abnormal_tail_morphology0.82104004
83MP0003195_calcinosis0.80250560
84MP0003119_abnormal_digestive_system0.80040061
85MP0003943_abnormal_hepatobiliary_system0.79049682
86MP0001986_abnormal_taste_sensitivity0.78898287
87MP0003806_abnormal_nucleotide_metabolis0.78030850
88MP0002882_abnormal_neuron_morphology0.77254401
89MP0005195_abnormal_posterior_eye0.77165518
90MP0002152_abnormal_brain_morphology0.77109558
91MP0009697_abnormal_copulation0.76817098
92MP0001188_hyperpigmentation0.73333476
93MP0002116_abnormal_craniofacial_bone0.70157474
94MP0003935_abnormal_craniofacial_develop0.70098961
95MP0000432_abnormal_head_morphology0.69863732
96MP0003942_abnormal_urinary_system0.67828220
97MP0002210_abnormal_sex_determination0.67694039
98MP0001177_atelectasis0.66870558
99MP0001929_abnormal_gametogenesis0.66841215
100MP0001293_anophthalmia0.65661915

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.24983075
2Dyschromatopsia (HP:0007641)4.61001530
3Oligodactyly (hands) (HP:0001180)4.52890743
4Volvulus (HP:0002580)4.49034110
5Large earlobe (HP:0009748)3.69203507
6Absent/shortened dynein arms (HP:0200106)3.46046861
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.46046861
8Nephronophthisis (HP:0000090)3.35071397
9Short 4th metacarpal (HP:0010044)3.34323844
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.34323844
11Pancreatic fibrosis (HP:0100732)3.34241607
12Oligodactyly (HP:0012165)3.24314236
13True hermaphroditism (HP:0010459)3.22457332
14Pancreatic cysts (HP:0001737)3.16662693
15Abnormality of the renal medulla (HP:0100957)3.11959587
16Abnormality of the aortic arch (HP:0012303)2.97454386
17Abnormality of midbrain morphology (HP:0002418)2.70174153
18Molar tooth sign on MRI (HP:0002419)2.70174153
19Abnormality of the 4th metacarpal (HP:0010012)2.69954680
20Abnormal respiratory epithelium morphology (HP:0012253)2.69540686
21Abnormal respiratory motile cilium morphology (HP:0005938)2.69540686
22Renal cortical cysts (HP:0000803)2.65951928
23Short clavicles (HP:0000894)2.65711124
24Abnormality of the renal cortex (HP:0011035)2.61698290
25Intestinal atresia (HP:0011100)2.58476206
26Adactyly (HP:0009776)2.56090721
27Focal motor seizures (HP:0011153)2.50822459
28Supernumerary spleens (HP:0009799)2.46622246
29Aplasia/Hypoplasia of the clavicles (HP:0006710)2.44220940
30Colon cancer (HP:0003003)2.40315734
31Abnormal ciliary motility (HP:0012262)2.39394108
32Increased hepatocellular lipid droplets (HP:0006565)2.36995526
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.32760834
34Tubulointerstitial nephritis (HP:0001970)2.29289593
35Anencephaly (HP:0002323)2.27673949
36Abnormality of the labia minora (HP:0012880)2.25685733
37Decreased central vision (HP:0007663)2.25514924
38Congenital hepatic fibrosis (HP:0002612)2.21790223
39Renal hypoplasia (HP:0000089)2.20009824
40Dysdiadochokinesis (HP:0002075)2.16337732
41Diastasis recti (HP:0001540)2.13525409
42High anterior hairline (HP:0009890)2.13363082
43Sclerocornea (HP:0000647)2.10390264
44Shawl scrotum (HP:0000049)2.09274246
45Mitochondrial inheritance (HP:0001427)2.08513001
46Lipid accumulation in hepatocytes (HP:0006561)2.08460316
47Occipital encephalocele (HP:0002085)2.07753813
48Cystic liver disease (HP:0006706)2.05462147
49Abnormal number of erythroid precursors (HP:0012131)2.01646903
50Abnormal respiratory motile cilium physiology (HP:0012261)1.99876532
51Hypobetalipoproteinemia (HP:0003563)1.96436812
52Neoplasm of the adrenal cortex (HP:0100641)1.96346257
53Glioma (HP:0009733)1.95190847
54Aplasia/Hypoplasia of the tibia (HP:0005772)1.94777265
55Conjunctival telangiectasia (HP:0000524)1.93785321
56Optic nerve hypoplasia (HP:0000609)1.92603357
57Sparse scalp hair (HP:0002209)1.91376805
58Attenuation of retinal blood vessels (HP:0007843)1.90247958
59Impulsivity (HP:0100710)1.89997113
60Abnormality of the proximal phalanges of the hand (HP:0009834)1.88720188
61Abnormality of macular pigmentation (HP:0008002)1.88155293
62Glycosuria (HP:0003076)1.87049278
63Abnormality of urine glucose concentration (HP:0011016)1.87049278
64Papillary thyroid carcinoma (HP:0002895)1.84953587
65Ependymoma (HP:0002888)1.84443071
66Bilateral microphthalmos (HP:0007633)1.83498735
67Increased CSF lactate (HP:0002490)1.83200070
68Depressed nasal tip (HP:0000437)1.83093922
69Abnormality of the antihelix (HP:0009738)1.82911844
70Fibular hypoplasia (HP:0003038)1.82517464
71Acute necrotizing encephalopathy (HP:0006965)1.81956125
72Tubulointerstitial abnormality (HP:0001969)1.80603800
73Bifid scrotum (HP:0000048)1.80338218
74Short tibia (HP:0005736)1.80336469
75Focal seizures (HP:0007359)1.79176302
76Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78802473
77Renal Fanconi syndrome (HP:0001994)1.78005458
78Methylmalonic acidemia (HP:0002912)1.77928403
79Increased nuchal translucency (HP:0010880)1.77149597
80Medulloblastoma (HP:0002885)1.74041014
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73092851
82Gastrointestinal atresia (HP:0002589)1.73052032
83Dandy-Walker malformation (HP:0001305)1.71384229
84Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70757684
85Global brain atrophy (HP:0002283)1.68716244
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.67959784
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67719323
88Pachygyria (HP:0001302)1.67682091
89Esophageal atresia (HP:0002032)1.64535352
90Abnormality of the lower motor neuron (HP:0002366)1.63966892
91Intellectual disability, moderate (HP:0002342)1.63937641
92Chronic hepatic failure (HP:0100626)1.63097315
9311 pairs of ribs (HP:0000878)1.62595341
94Male pseudohermaphroditism (HP:0000037)1.62100499
95Broad foot (HP:0001769)1.61859801
96Neurodegeneration (HP:0002180)1.61697626
97Hypothermia (HP:0002045)1.61205277
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.60648893
99Pulmonary artery stenosis (HP:0004415)1.60069485
100Supernumerary ribs (HP:0005815)1.59657920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.69116067
2VRK23.60684812
3NUAK13.25711728
4BMPR1B3.20474161
5MAPK133.07615334
6WNK32.78875512
7PLK42.58587129
8BUB12.41001669
9ZAK2.22986713
10MARK12.20308763
11PRKD32.19089869
12EPHA41.96165693
13TRIM281.93814503
14STK38L1.85957328
15ADRBK21.78026488
16CCNB11.75952272
17NTRK31.70537490
18STK391.69137331
19PINK11.58645012
20ACVR1B1.53261008
21DYRK31.43572397
22MAP3K41.43506190
23ERBB31.40423013
24MKNK11.35279639
25MAP2K21.30705665
26VRK11.29945208
27TAF11.18536641
28MAPK71.16246537
29OXSR11.16216801
30PLK21.15927364
31MAP4K21.14995598
32SIK21.14983943
33TGFBR11.14021675
34WEE11.13294854
35TNIK1.09814240
36MKNK21.09392668
37PBK1.06783704
38CDC71.03752810
39NME11.00360863
40MAPK150.96737325
41FRK0.96665821
42PKN10.96269671
43PRKD20.95779518
44DYRK20.91245395
45CHUK0.89148865
46GRK10.87132501
47PAK30.85286300
48TLK10.83040363
49CAMK2D0.82379000
50WNK40.81835859
51PASK0.78475010
52CDK30.77394340
53PTK2B0.76838623
54ATR0.73525579
55SRPK10.71885543
56PLK30.71531055
57EIF2AK20.71128632
58HIPK20.70479968
59EIF2AK30.69894482
60PRKCE0.69699370
61PRKCI0.67902737
62RAF10.65886732
63INSRR0.64673790
64ADRBK10.64397217
65PHKG20.64059854
66PHKG10.64059854
67BCR0.59599555
68CSNK1G10.59023871
69ROCK10.56987774
70TEC0.56906182
71MELK0.54217085
72GSK3A0.53467444
73ATM0.53042247
74RPS6KA40.51932440
75PLK10.51900228
76CDK70.50730740
77NEK20.50666231
78STK40.49223027
79RPS6KA50.47817171
80CAMK2B0.47191794
81AURKB0.45191286
82DMPK0.45106823
83FGFR10.43808325
84PRKCG0.42952494
85DYRK1A0.39338923
86MINK10.38414705
87TAOK10.37975086
88STK380.37449628
89LIMK10.37174613
90TIE10.34958022
91PNCK0.34809945
92PRKCQ0.34362748
93IGF1R0.33962680
94PRKG10.33812487
95STK110.33555256
96NTRK20.33164623
97CSNK1G20.32986340
98OBSCN0.32963881
99RPS6KA10.32574848
100MAP3K100.32435454

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.80365633
2Phototransduction_Homo sapiens_hsa047443.32896188
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.32420105
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.88035610
5Butanoate metabolism_Homo sapiens_hsa006502.66126935
6Basal transcription factors_Homo sapiens_hsa030222.63830711
7Linoleic acid metabolism_Homo sapiens_hsa005912.12290890
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00417682
9Vitamin B6 metabolism_Homo sapiens_hsa007502.00055862
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.95886325
11Propanoate metabolism_Homo sapiens_hsa006401.91765047
12Fanconi anemia pathway_Homo sapiens_hsa034601.89454177
13Oxidative phosphorylation_Homo sapiens_hsa001901.84577917
14Nitrogen metabolism_Homo sapiens_hsa009101.82312993
15Protein export_Homo sapiens_hsa030601.80946599
16Non-homologous end-joining_Homo sapiens_hsa034501.79381261
17Parkinsons disease_Homo sapiens_hsa050121.53739288
18Nicotine addiction_Homo sapiens_hsa050331.44059322
19Huntingtons disease_Homo sapiens_hsa050161.43728757
20beta-Alanine metabolism_Homo sapiens_hsa004101.41276303
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38590482
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35665484
23Cardiac muscle contraction_Homo sapiens_hsa042601.31929275
24Basal cell carcinoma_Homo sapiens_hsa052171.29871635
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26512455
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25446492
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25347882
28Hedgehog signaling pathway_Homo sapiens_hsa043401.18888538
29Caffeine metabolism_Homo sapiens_hsa002321.18451844
30Olfactory transduction_Homo sapiens_hsa047401.17118019
31Homologous recombination_Homo sapiens_hsa034401.16875076
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16861826
33Ribosome_Homo sapiens_hsa030101.15266043
34Spliceosome_Homo sapiens_hsa030401.14278335
35RNA degradation_Homo sapiens_hsa030181.11926167
36Arachidonic acid metabolism_Homo sapiens_hsa005901.11848832
37Circadian entrainment_Homo sapiens_hsa047131.09993570
38African trypanosomiasis_Homo sapiens_hsa051431.08243924
39TGF-beta signaling pathway_Homo sapiens_hsa043501.05126390
40Cell cycle_Homo sapiens_hsa041101.04393568
41Proteasome_Homo sapiens_hsa030501.01307347
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99000370
43Chemical carcinogenesis_Homo sapiens_hsa052040.94568731
44Lysine degradation_Homo sapiens_hsa003100.92553602
45Amphetamine addiction_Homo sapiens_hsa050310.90251291
46GABAergic synapse_Homo sapiens_hsa047270.89477234
47Ether lipid metabolism_Homo sapiens_hsa005650.88799307
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88786771
49Steroid biosynthesis_Homo sapiens_hsa001000.87644563
50RNA transport_Homo sapiens_hsa030130.86317327
51Cholinergic synapse_Homo sapiens_hsa047250.85119876
52Fat digestion and absorption_Homo sapiens_hsa049750.82698378
53Tryptophan metabolism_Homo sapiens_hsa003800.82607601
54Taste transduction_Homo sapiens_hsa047420.81830501
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79932521
56Base excision repair_Homo sapiens_hsa034100.78921610
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75348558
58Cocaine addiction_Homo sapiens_hsa050300.74639833
59Glycerolipid metabolism_Homo sapiens_hsa005610.70917579
60Fatty acid elongation_Homo sapiens_hsa000620.70392707
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68389111
62Nucleotide excision repair_Homo sapiens_hsa034200.68014669
63Wnt signaling pathway_Homo sapiens_hsa043100.67464700
64Retinol metabolism_Homo sapiens_hsa008300.67341037
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67015788
66Systemic lupus erythematosus_Homo sapiens_hsa053220.65890591
67Alzheimers disease_Homo sapiens_hsa050100.65786462
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63586285
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.63479995
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62841113
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60357764
72Oocyte meiosis_Homo sapiens_hsa041140.60291810
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.59921061
74Fatty acid degradation_Homo sapiens_hsa000710.56281671
75Glutamatergic synapse_Homo sapiens_hsa047240.56224292
76Circadian rhythm_Homo sapiens_hsa047100.54826518
77Alcoholism_Homo sapiens_hsa050340.54114380
78Serotonergic synapse_Homo sapiens_hsa047260.53574178
79Fatty acid metabolism_Homo sapiens_hsa012120.53490899
80p53 signaling pathway_Homo sapiens_hsa041150.52719952
81Purine metabolism_Homo sapiens_hsa002300.49464226
82Hippo signaling pathway_Homo sapiens_hsa043900.48106360
83cAMP signaling pathway_Homo sapiens_hsa040240.48088398
84Melanogenesis_Homo sapiens_hsa049160.47457190
85Dopaminergic synapse_Homo sapiens_hsa047280.47088842
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46847393
87Mismatch repair_Homo sapiens_hsa034300.45897705
88Colorectal cancer_Homo sapiens_hsa052100.44340623
89Axon guidance_Homo sapiens_hsa043600.43684410
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.43393663
91Selenocompound metabolism_Homo sapiens_hsa004500.41275724
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41035290
93Calcium signaling pathway_Homo sapiens_hsa040200.39489701
94Ovarian steroidogenesis_Homo sapiens_hsa049130.38736538
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38116283
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37034888
97Insulin secretion_Homo sapiens_hsa049110.34387434
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34021605
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.33737095
100Peroxisome_Homo sapiens_hsa041460.33292592

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