RLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synaptic transmission, dopaminergic (GO:0032226)7.98354567
2regulation of synapse structural plasticity (GO:0051823)7.77027483
3behavioral response to ethanol (GO:0048149)7.16828652
4regulation of inhibitory postsynaptic membrane potential (GO:0060080)6.36854008
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.31027728
6short-term memory (GO:0007614)6.19995094
7regulation of dopamine uptake involved in synaptic transmission (GO:0051584)5.98400988
8regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)5.98400988
9neuron cell-cell adhesion (GO:0007158)5.93220395
10regulation of synaptic transmission, dopaminergic (GO:0032225)5.53189064
11postsynaptic membrane organization (GO:0001941)5.29940484
12regulation of neurotransmitter uptake (GO:0051580)5.27898555
13response to pheromone (GO:0019236)5.22900912
14vocalization behavior (GO:0071625)5.17148960
15synaptic vesicle exocytosis (GO:0016079)5.16936795
16peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.11292452
17presynaptic membrane assembly (GO:0097105)4.93903203
18protein localization to synapse (GO:0035418)4.86778284
19synaptic transmission, dopaminergic (GO:0001963)4.83489607
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.69951080
21positive regulation of dendritic spine development (GO:0060999)4.67267627
22synaptic vesicle maturation (GO:0016188)4.58966530
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51468098
24rRNA modification (GO:0000154)4.48366773
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46023778
26behavioral response to nicotine (GO:0035095)4.43593810
27regulation of meiosis I (GO:0060631)4.29799522
28presynaptic membrane organization (GO:0097090)4.29221806
29regulation of glutamate receptor signaling pathway (GO:1900449)4.28063512
30response to histamine (GO:0034776)4.25979904
31layer formation in cerebral cortex (GO:0021819)4.21835911
32rRNA methylation (GO:0031167)4.19656891
33positive regulation of membrane potential (GO:0045838)4.14915558
34respiratory chain complex IV assembly (GO:0008535)4.14838942
35behavioral response to cocaine (GO:0048148)4.14410028
36behavioral fear response (GO:0001662)3.97361628
37behavioral defense response (GO:0002209)3.97361628
38positive regulation of neurotransmitter transport (GO:0051590)3.90062997
39cytochrome complex assembly (GO:0017004)3.86964940
40positive regulation of actin filament depolymerization (GO:0030836)3.86319197
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.86033825
42adult feeding behavior (GO:0008343)3.85817836
43auditory receptor cell differentiation (GO:0042491)3.85167775
44microtubule severing (GO:0051013)3.80445000
45protein complex biogenesis (GO:0070271)3.79296334
46regulation of helicase activity (GO:0051095)3.76016766
47positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.74604389
48energy coupled proton transport, down electrochemical gradient (GO:0015985)3.74125077
49ATP synthesis coupled proton transport (GO:0015986)3.74125077
50membrane hyperpolarization (GO:0060081)3.73709362
51piRNA metabolic process (GO:0034587)3.73570721
52positive regulation of sodium ion transmembrane transport (GO:1902307)3.73127661
53fear response (GO:0042596)3.71014753
54protein neddylation (GO:0045116)3.68694567
55branched-chain amino acid catabolic process (GO:0009083)3.68675081
56purine nucleobase biosynthetic process (GO:0009113)3.67795208
57heme transport (GO:0015886)3.67265183
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.66016961
59NADH dehydrogenase complex assembly (GO:0010257)3.66016961
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66016961
61meiotic cell cycle (GO:0051321)3.65216994
62regulation of penile erection (GO:0060405)3.64453231
63response to hydroperoxide (GO:0033194)3.63230913
64CENP-A containing nucleosome assembly (GO:0034080)3.61174280
65positive regulation of uterine smooth muscle contraction (GO:0070474)3.57017220
66regulation of response to food (GO:0032095)3.55680455
67regulation of dopamine metabolic process (GO:0042053)3.54743383
68regulation of catecholamine metabolic process (GO:0042069)3.54743383
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.51786321
70sequestering of actin monomers (GO:0042989)3.51147795
71poly(A)+ mRNA export from nucleus (GO:0016973)3.47756726
72negative regulation of neurotransmitter transport (GO:0051589)3.47017551
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.45246790
74positive regulation of histone H3-K4 methylation (GO:0051571)3.44907034
75negative regulation of microtubule polymerization (GO:0031115)3.44454272
76chromatin remodeling at centromere (GO:0031055)3.44352475
77positive regulation of synapse assembly (GO:0051965)3.42304532
78social behavior (GO:0035176)3.41969086
79intraspecies interaction between organisms (GO:0051703)3.41969086
80negative regulation of execution phase of apoptosis (GO:1900118)3.40965209
81neurotransmitter-gated ion channel clustering (GO:0072578)3.40770929
82chaperone-mediated protein transport (GO:0072321)3.40383978
83mitochondrial respiratory chain complex assembly (GO:0033108)3.38274037
84regulation of dendritic spine development (GO:0060998)3.36002723
85positive regulation of mitotic sister chromatid separation (GO:1901970)3.35110049
86positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.35110049
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.35110049
88respiratory electron transport chain (GO:0022904)3.32098731
89regulation of short-term neuronal synaptic plasticity (GO:0048172)3.31914081
90water-soluble vitamin biosynthetic process (GO:0042364)3.30286536
91electron transport chain (GO:0022900)3.27889992
92neuron recognition (GO:0008038)3.27864511
93regulation of histone H3-K9 methylation (GO:0051570)3.25675125
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23555375
95regulation of mitotic spindle checkpoint (GO:1903504)3.23555375
96adenosine metabolic process (GO:0046085)3.18292145
97postreplication repair (GO:0006301)3.16842437
98centriole replication (GO:0007099)3.16228762
99proteasome assembly (GO:0043248)3.14422991
100regulation of synapse organization (GO:0050807)3.13496947
101exploration behavior (GO:0035640)3.12884809
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11326101
103glutamate secretion (GO:0014047)3.10684554
104adaptation of signaling pathway (GO:0023058)3.10209690
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09273602
106regulation of synaptic transmission, glutamatergic (GO:0051966)3.07132656
107locomotory exploration behavior (GO:0035641)3.05975137
108single strand break repair (GO:0000012)3.05423374
109regulation of uterine smooth muscle contraction (GO:0070472)3.05372868
110neurotransmitter secretion (GO:0007269)3.03447068
111serotonin metabolic process (GO:0042428)3.02998875
112positive regulation of dendritic spine morphogenesis (GO:0061003)3.02966712
113platelet dense granule organization (GO:0060155)3.00022247
114translesion synthesis (GO:0019985)2.99120186
115neuron-neuron synaptic transmission (GO:0007270)2.99023690
116gamma-aminobutyric acid transport (GO:0015812)2.98291383
117transcription elongation from RNA polymerase III promoter (GO:0006385)2.97395371
118termination of RNA polymerase III transcription (GO:0006386)2.97395371
119positive regulation of synapse maturation (GO:0090129)2.97151144
120preassembly of GPI anchor in ER membrane (GO:0016254)2.96832797
121chemosensory behavior (GO:0007635)2.96594634
122regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96493338
123synapse assembly (GO:0007416)2.96357317
124aggressive behavior (GO:0002118)2.95742835
125positive regulation of amine transport (GO:0051954)2.95731938
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.95335449
127regulation of acrosome reaction (GO:0060046)2.94346376
128mechanosensory behavior (GO:0007638)2.94016403
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93166905
130male meiosis I (GO:0007141)2.93130677
131exogenous drug catabolic process (GO:0042738)2.92318192
132regulation of postsynaptic membrane potential (GO:0060078)2.91649226
133regulation of dendritic spine morphogenesis (GO:0061001)2.90474886
134regulation of appetite (GO:0032098)2.90087806
135nucleobase biosynthetic process (GO:0046112)2.89910888
136brain morphogenesis (GO:0048854)2.89594613
137cerebellar Purkinje cell differentiation (GO:0021702)2.89425600
138peptidyl-cysteine modification (GO:0018198)2.89091859
139DNA methylation involved in gamete generation (GO:0043046)2.88243181
140retinal cone cell development (GO:0046549)2.87720482
141negative regulation of appetite (GO:0032099)2.87542558
142negative regulation of response to food (GO:0032096)2.87542558
143ionotropic glutamate receptor signaling pathway (GO:0035235)2.86943250
144RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85755717
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85755717
146synapsis (GO:0007129)2.85677701
147pseudouridine synthesis (GO:0001522)2.84591225
148regulation of execution phase of apoptosis (GO:1900117)2.84455199
149positive regulation of chromosome segregation (GO:0051984)2.83600280
150relaxation of smooth muscle (GO:0044557)2.83343491
151branched-chain amino acid metabolic process (GO:0009081)2.83219053
152regulation of glucokinase activity (GO:0033131)2.82971282
153regulation of hexokinase activity (GO:1903299)2.82971282
154DNA replication-independent nucleosome organization (GO:0034724)2.82648798
155DNA replication-independent nucleosome assembly (GO:0006336)2.82648798
156regulation of voltage-gated calcium channel activity (GO:1901385)2.81570325
157replication fork processing (GO:0031297)2.79497286
158somite rostral/caudal axis specification (GO:0032525)2.79111193
159regulation of female gonad development (GO:2000194)2.78033861
160DNA deamination (GO:0045006)2.77407141
161calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.77118034
162positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76855733
163nucleotide-excision repair, DNA gap filling (GO:0006297)2.76211303
164membrane assembly (GO:0071709)2.75731512
165meiosis I (GO:0007127)2.75362640
166glutamate receptor signaling pathway (GO:0007215)2.74527340
167positive regulation of protein export from nucleus (GO:0046827)2.74384869
168transcription-coupled nucleotide-excision repair (GO:0006283)2.74249327
169ribosomal small subunit assembly (GO:0000028)2.73008547
170purine-containing compound salvage (GO:0043101)2.71728477
171regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71197443
172regulation of synapse assembly (GO:0051963)2.71102330
173mitotic cell cycle arrest (GO:0071850)2.69784900
174negative regulation of adenylate cyclase activity (GO:0007194)2.69578951
175maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68972980
176establishment of melanosome localization (GO:0032401)2.68467556
177regulation of DNA endoreduplication (GO:0032875)2.68349410
178telomere maintenance via semi-conservative replication (GO:0032201)2.67785018
179regulation of synaptic vesicle exocytosis (GO:2000300)2.67625062
180histone exchange (GO:0043486)2.67166118
181energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.67041495
182ATP hydrolysis coupled proton transport (GO:0015991)2.67041495
183positive regulation of synaptic transmission (GO:0050806)2.66332257
184termination of RNA polymerase I transcription (GO:0006363)2.65986128
185protein localization to cilium (GO:0061512)2.65698935
186transcription elongation from RNA polymerase I promoter (GO:0006362)2.65684360
187positive regulation of gastrulation (GO:2000543)2.64682007
188regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.63518027
189dendritic spine morphogenesis (GO:0060997)2.61962909
1907-methylguanosine mRNA capping (GO:0006370)2.59838272
191mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59751522
192mismatch repair (GO:0006298)2.58550155
1937-methylguanosine RNA capping (GO:0009452)2.53712789
194RNA capping (GO:0036260)2.53712789
195lactate metabolic process (GO:0006089)2.53192232
196male meiosis (GO:0007140)2.50452288
197negative regulation of cAMP-mediated signaling (GO:0043951)2.49075196
198C-terminal protein lipidation (GO:0006501)2.47041727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.87041568
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.08037817
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51413429
4GBX2_23144817_ChIP-Seq_PC3_Human3.45122535
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.35517194
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24360135
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.22722210
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20598289
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.03228561
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.96503408
11E2F7_22180533_ChIP-Seq_HELA_Human2.93771123
12AR_21572438_ChIP-Seq_LNCaP_Human2.92177345
13IGF1R_20145208_ChIP-Seq_DFB_Human2.89424485
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85465495
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84651674
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.81320074
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.80308282
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75927982
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75927982
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74049718
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68962558
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.66927459
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65094963
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.64385684
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54570781
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47843852
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39609310
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.39387365
29VDR_23849224_ChIP-Seq_CD4+_Human2.37340898
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23388784
31EWS_26573619_Chip-Seq_HEK293_Human2.19157591
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17956297
33FUS_26573619_Chip-Seq_HEK293_Human2.17556310
34ELK1_19687146_ChIP-ChIP_HELA_Human2.15648674
35CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15207545
36REST_21632747_ChIP-Seq_MESCs_Mouse2.14609528
37FOXP3_21729870_ChIP-Seq_TREG_Human2.13606095
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12086799
39SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09879401
40E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09226357
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.08827708
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07481885
43BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06504427
44PADI4_21655091_ChIP-ChIP_MCF-7_Human2.03877692
45RNF2_27304074_Chip-Seq_ESCs_Mouse2.02199535
46EZH2_27294783_Chip-Seq_ESCs_Mouse2.01515858
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00463115
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99218895
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98828470
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.96678247
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.96214658
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94231631
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.87153900
54AR_21909140_ChIP-Seq_LNCAP_Human1.81661889
55HTT_18923047_ChIP-ChIP_STHdh_Human1.80554839
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79865874
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.79846483
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79180708
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.78489874
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.76814763
61RNF2_27304074_Chip-Seq_NSC_Mouse1.76643253
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75529875
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70555880
64TAF15_26573619_Chip-Seq_HEK293_Human1.68605080
65ZNF274_21170338_ChIP-Seq_K562_Hela1.68420956
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67622994
67* MYC_18940864_ChIP-ChIP_HL60_Human1.65868071
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65379414
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65128557
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.64902670
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56154896
72P300_19829295_ChIP-Seq_ESCs_Human1.55010454
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.53976161
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51470956
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49627406
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.49445321
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43821079
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43429805
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43423408
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39106321
81SMAD4_21799915_ChIP-Seq_A2780_Human1.37196938
82* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36304126
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32367333
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30789639
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.30360247
86ER_23166858_ChIP-Seq_MCF-7_Human1.29474061
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29048445
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24901134
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.24505244
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.24360804
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23148989
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22759725
93TP53_22573176_ChIP-Seq_HFKS_Human1.21588984
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20614756
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16698903
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16240574
97DCP1A_22483619_ChIP-Seq_HELA_Human1.14696674
98AR_20517297_ChIP-Seq_VCAP_Human1.14631526
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13742698
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13268589
101TTF2_22483619_ChIP-Seq_HELA_Human1.12724238
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.12583065
103GABP_19822575_ChIP-Seq_HepG2_Human1.12400813
104FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12224618
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.12224618
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11495144
107IRF1_19129219_ChIP-ChIP_H3396_Human1.07545197
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07101943
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06173813
110YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06037290
111VDR_22108803_ChIP-Seq_LS180_Human1.05695005
112JUN_21703547_ChIP-Seq_K562_Human1.05540471
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.05239387
114AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04747079
115NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03423805
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.02286795
117TP53_18474530_ChIP-ChIP_U2OS_Human1.02275179
118BCAT_22108803_ChIP-Seq_LS180_Human1.01480971
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00943113
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00640241
121SALL4_22934838_ChIP-ChIP_CD34+_Human0.99667090
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98393782
123MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98190858
124RARB_27405468_Chip-Seq_BRAIN_Mouse0.98094588
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97835040
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97815374
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.97359088
128* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97315280
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96577294
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96435011
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95643164
132TRIM28_21343339_ChIP-Seq_HEK293_Human0.94465703
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94146601
134SOX9_26525672_Chip-Seq_HEART_Mouse0.93349902
135STAT3_23295773_ChIP-Seq_U87_Human0.93151022
136RUNX2_22187159_ChIP-Seq_PCA_Human0.92619407
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92546278
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.91341801
139TCF4_23295773_ChIP-Seq_U87_Human0.90573459
140NANOG_16153702_ChIP-ChIP_HESCs_Human0.90538310
141AHR_22903824_ChIP-Seq_MCF-7_Human0.90315637
142* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90229034
143ERG_20517297_ChIP-Seq_VCAP_Human0.90039789
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89951546
145TAL1_26923725_Chip-Seq_HPCs_Mouse0.89576028
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88923188
147* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88696391
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88607452
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88445660
150EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88016721
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.87919522
152DROSHA_22980978_ChIP-Seq_HELA_Human0.87680736
153CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87625286
154ELF5_23300383_ChIP-Seq_T47D_Human0.87605226
155AR_25329375_ChIP-Seq_VCAP_Human0.86685529
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86588397
157SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86477524
158SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86305074
159TCF4_22108803_ChIP-Seq_LS180_Human0.86284350
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85987386
161KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85410356
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85399496
163EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85369953
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.84764285
165KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84655596
166TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84308591
167HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83910902
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.83281154
169ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82881993
170CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82877755
171IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82604934
172CBP_20019798_ChIP-Seq_JUKART_Human0.82604934
173ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82571073
174CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81543673
175TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81375758
176MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81103918
177TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80963201
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80271213
179CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79478808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.50589739
2MP0002254_reproductive_system_inflammat3.73346314
3MP0002138_abnormal_hepatobiliary_system3.64896987
4MP0003122_maternal_imprinting3.47044983
5MP0006276_abnormal_autonomic_nervous3.26709609
6MP0004859_abnormal_synaptic_plasticity3.21963232
7MP0003880_abnormal_central_pattern3.13653408
8MP0003879_abnormal_hair_cell3.13377035
9MP0003787_abnormal_imprinting3.10773146
10MP0008877_abnormal_DNA_methylation3.04135622
11MP0005645_abnormal_hypothalamus_physiol2.96533412
12MP0003635_abnormal_synaptic_transmissio2.89010905
13MP0008058_abnormal_DNA_repair2.82120528
14MP0003011_delayed_dark_adaptation2.81285264
15MP0002572_abnormal_emotion/affect_behav2.72610247
16MP0001529_abnormal_vocalization2.72415468
17MP0003693_abnormal_embryo_hatching2.66501510
18MP0009745_abnormal_behavioral_response2.66210027
19MP0008057_abnormal_DNA_replication2.65946465
20MP0010234_abnormal_vibrissa_follicle2.62837689
21MP0004858_abnormal_nervous_system2.56729170
22MP0002064_seizures2.48389906
23MP0002063_abnormal_learning/memory/cond2.46904518
24MP0009046_muscle_twitch2.37826551
25MP0004270_analgesia2.35286197
26MP0001188_hyperpigmentation2.31992650
27MP0001968_abnormal_touch/_nociception2.12746224
28MP0004957_abnormal_blastocyst_morpholog2.10652465
29MP0002272_abnormal_nervous_system2.08919352
30MP0004133_heterotaxia2.08354059
31MP0010094_abnormal_chromosome_stability2.07939497
32MP0006072_abnormal_retinal_apoptosis2.05138330
33MP0001440_abnormal_grooming_behavior2.02533813
34MP0001501_abnormal_sleep_pattern2.01462962
35MP0002557_abnormal_social/conspecific_i1.98646023
36MP0002734_abnormal_mechanical_nocicepti1.95099520
37MP0002102_abnormal_ear_morphology1.94673089
38MP0003121_genomic_imprinting1.93006570
39MP0006054_spinal_hemorrhage1.91669303
40MP0002837_dystrophic_cardiac_calcinosis1.87790482
41MP0000778_abnormal_nervous_system1.84999307
42MP0001905_abnormal_dopamine_level1.81790496
43MP0003111_abnormal_nucleus_morphology1.81679898
44MP0002736_abnormal_nociception_after1.75499375
45MP0001486_abnormal_startle_reflex1.70279301
46MP0002234_abnormal_pharynx_morphology1.69777410
47MP0005423_abnormal_somatic_nervous1.67032628
48MP0003941_abnormal_skin_development1.65760650
49MP0001919_abnormal_reproductive_system1.64803043
50MP0002184_abnormal_innervation1.61272395
51MP0005167_abnormal_blood-brain_barrier1.52992784
52MP0005389_reproductive_system_phenotype1.52938810
53MP0005671_abnormal_response_to1.51354555
54MP0003136_yellow_coat_color1.49689294
55MP0005187_abnormal_penis_morphology1.49040559
56MP0003646_muscle_fatigue1.48857945
57MP0004811_abnormal_neuron_physiology1.45479903
58MP0009379_abnormal_foot_pigmentation1.43376932
59MP0001485_abnormal_pinna_reflex1.41170920
60MP0002735_abnormal_chemical_nociception1.38863542
61MP0003329_amyloid_beta_deposits1.38807046
62MP0008932_abnormal_embryonic_tissue1.36329171
63MP0005395_other_phenotype1.35990638
64MP0003718_maternal_effect1.35773666
65MP0004142_abnormal_muscle_tone1.34856419
66MP0003077_abnormal_cell_cycle1.34109109
67MP0005410_abnormal_fertilization1.31836114
68MP0008789_abnormal_olfactory_epithelium1.31585706
69MP0001764_abnormal_homeostasis1.31109410
70MP0002733_abnormal_thermal_nociception1.30867670
71MP0005646_abnormal_pituitary_gland1.30161807
72* MP0002210_abnormal_sex_determination1.29303242
73MP0004043_abnormal_pH_regulation1.28990529
74MP0005394_taste/olfaction_phenotype1.27248268
75MP0005499_abnormal_olfactory_system1.27248268
76MP0002067_abnormal_sensory_capabilities1.27108950
77MP0001881_abnormal_mammary_gland1.26679588
78MP0002160_abnormal_reproductive_system1.25241461
79MP0006036_abnormal_mitochondrial_physio1.24974198
80MP0001970_abnormal_pain_threshold1.23964762
81MP0003786_premature_aging1.23240005
82MP0002249_abnormal_larynx_morphology1.22672533
83MP0001849_ear_inflammation1.21610749
84MP0004233_abnormal_muscle_weight1.21492211
85MP0006292_abnormal_olfactory_placode1.20802245
86MP0002882_abnormal_neuron_morphology1.19572753
87* MP0000653_abnormal_sex_gland1.19060412
88MP0000631_abnormal_neuroendocrine_gland1.16583278
89MP0008995_early_reproductive_senescence1.15702548
90MP0005171_absent_coat_pigmentation1.15176237
91MP0005253_abnormal_eye_physiology1.12488868
92MP0002132_abnormal_respiratory_system1.11421383
93MP0009780_abnormal_chondrocyte_physiolo1.10719047
94MP0001963_abnormal_hearing_physiology1.10486510
95MP0005647_abnormal_sex_gland1.10312513
96MP0000751_myopathy1.10023586
97* MP0001929_abnormal_gametogenesis1.08205003
98MP0002909_abnormal_adrenal_gland1.07647842
99MP0002396_abnormal_hematopoietic_system1.06726784
100MP0001984_abnormal_olfaction1.06460731
101MP0004924_abnormal_behavior1.06423081
102MP0005386_behavior/neurological_phenoty1.06423081
103* MP0001145_abnormal_male_reproductive1.05764080
104MP0003890_abnormal_embryonic-extraembry1.05207043
105MP0001756_abnormal_urination1.05182741
106MP0001119_abnormal_female_reproductive1.03787103
107MP0002152_abnormal_brain_morphology1.03602333
108MP0009115_abnormal_fat_cell1.03004991
109MP0005636_abnormal_mineral_homeostasis1.02248670
110MP0005623_abnormal_meninges_morphology1.02057065
111MP0005220_abnormal_exocrine_pancreas1.01683383
112* MP0003699_abnormal_female_reproductive1.01283291
113MP0004145_abnormal_muscle_electrophysio0.99941312
114MP0003137_abnormal_impulse_conducting0.99469965
115MP0002066_abnormal_motor_capabilities/c0.98308857
116MP0005084_abnormal_gallbladder_morpholo0.96556318
117MP0004215_abnormal_myocardial_fiber0.95276513
118MP0005595_abnormal_vascular_smooth0.95062426
119MP0000026_abnormal_inner_ear0.94111846
120MP0004036_abnormal_muscle_relaxation0.93902534
121MP0000049_abnormal_middle_ear0.93731995
122MP0003186_abnormal_redox_activity0.92632670
123MP0002233_abnormal_nose_morphology0.92605150
124MP0002752_abnormal_somatic_nervous0.92527907
125MP0002006_tumorigenesis0.90164383
126MP0001730_embryonic_growth_arrest0.89767922
127MP0002928_abnormal_bile_duct0.89502642
128* MP0003698_abnormal_male_reproductive0.89404092
129MP0001944_abnormal_pancreas_morphology0.88582665
130MP0004019_abnormal_vitamin_homeostasis0.88416513
131MP0005451_abnormal_body_composition0.87975716
132MP0004883_abnormal_blood_vessel0.87680199
133MP0001293_anophthalmia0.87586800
134MP0002751_abnormal_autonomic_nervous0.86808379
135MP0005085_abnormal_gallbladder_physiolo0.84597182
136MP0003632_abnormal_nervous_system0.84106031
137MP0004147_increased_porphyrin_level0.82603265
138MP0000534_abnormal_ureter_morphology0.82402528
139MP0001727_abnormal_embryo_implantation0.82180844
140MP0008874_decreased_physiological_sensi0.80321243
141MP0000955_abnormal_spinal_cord0.80084213
142MP0005332_abnormal_amino_acid0.79960160
143MP0002693_abnormal_pancreas_physiology0.79309544
144MP0008569_lethality_at_weaning0.78453737
145* MP0002161_abnormal_fertility/fecundity0.77976849
146MP0002166_altered_tumor_susceptibility0.75878347
147MP0003861_abnormal_nervous_system0.75575019
148MP0010368_abnormal_lymphatic_system0.75553829
149* MP0002069_abnormal_eating/drinking_beha0.74319434
150MP0003631_nervous_system_phenotype0.72755284
151MP0005075_abnormal_melanosome_morpholog0.72682657
152MP0004084_abnormal_cardiac_muscle0.71212234
153MP0002090_abnormal_vision0.70748278
154MP0000230_abnormal_systemic_arterial0.70203552
155MP0004085_abnormal_heartbeat0.70025239
156MP0008872_abnormal_physiological_respon0.69162612
157MP0002332_abnormal_exercise_endurance0.68057495
158MP0001664_abnormal_digestion0.67919930
159MP0002938_white_spotting0.67762157
160MP0003119_abnormal_digestive_system0.67447925
161MP0002277_abnormal_respiratory_mucosa0.66913294
162MP0003385_abnormal_body_wall0.66692868
163MP0005551_abnormal_eye_electrophysiolog0.66209982
164MP0001986_abnormal_taste_sensitivity0.65900726
165* MP0003936_abnormal_reproductive_system0.65897949
166MP0008007_abnormal_cellular_replicative0.63835508
167MP0005174_abnormal_tail_pigmentation0.63551640
168MP0002009_preneoplasia0.63287670
169MP0002229_neurodegeneration0.62133494
170MP0003567_abnormal_fetal_cardiomyocyte0.61501786

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)5.35436043
2Abnormality of the labia minora (HP:0012880)4.80359465
3Focal motor seizures (HP:0011153)4.22562519
4Long foot (HP:0001833)4.13496074
5Aplastic anemia (HP:0001915)4.04691342
6Increased hepatocellular lipid droplets (HP:0006565)3.84760124
7Impaired vibration sensation in the lower limbs (HP:0002166)3.77966053
8Renal Fanconi syndrome (HP:0001994)3.77589526
9Exertional dyspnea (HP:0002875)3.62586769
10Insidious onset (HP:0003587)3.50401611
11Termporal pattern (HP:0011008)3.50401611
12Lipid accumulation in hepatocytes (HP:0006561)3.49403189
13Abnormal ciliary motility (HP:0012262)3.45861248
14Abnormal eating behavior (HP:0100738)3.33014490
15Methylmalonic acidemia (HP:0002912)3.32220432
16Abnormal hair whorl (HP:0010721)3.31421236
17Narrow nasal bridge (HP:0000446)3.31208178
18Abnormality of the corticospinal tract (HP:0002492)3.26873685
19Hyperglycinemia (HP:0002154)3.23173381
20Focal seizures (HP:0007359)3.20211557
21Epileptic encephalopathy (HP:0200134)3.19143133
22Gonadotropin excess (HP:0000837)3.18717764
23Progressive cerebellar ataxia (HP:0002073)3.17757258
24Hypoplasia of the uterus (HP:0000013)3.15628317
25Bile duct proliferation (HP:0001408)3.14094655
26Abnormal biliary tract physiology (HP:0012439)3.14094655
27Proximal tubulopathy (HP:0000114)3.11175111
28Myokymia (HP:0002411)3.09839153
29Abnormal respiratory motile cilium physiology (HP:0012261)3.07830867
30Fibular aplasia (HP:0002990)3.07434248
31Abnormality of midbrain morphology (HP:0002418)3.03210579
32Molar tooth sign on MRI (HP:0002419)3.03210579
33Gait imbalance (HP:0002141)3.00690524
34Tetraparesis (HP:0002273)2.99130659
35Glycosuria (HP:0003076)2.98831903
36Abnormality of urine glucose concentration (HP:0011016)2.98831903
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.96010852
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.96010852
39Upper limb muscle weakness (HP:0003484)2.87382525
40Hepatic necrosis (HP:0002605)2.86440358
41Increased intramyocellular lipid droplets (HP:0012240)2.85383947
42Pancytopenia (HP:0001876)2.84735189
43Supernumerary spleens (HP:0009799)2.81881988
44Mutism (HP:0002300)2.79064025
45Increased CSF lactate (HP:0002490)2.76558496
46Abnormality of renal resorption (HP:0011038)2.75679423
47True hermaphroditism (HP:0010459)2.72592510
48Pancreatic fibrosis (HP:0100732)2.70632493
49Neoplasm of head and neck (HP:0012288)2.68165843
50Esophageal neoplasm (HP:0100751)2.68165843
51Median cleft lip (HP:0000161)2.64684539
52Abnormality of dentin (HP:0010299)2.64207964
53Aplasia/hypoplasia of the uterus (HP:0008684)2.63413726
54Congenital primary aphakia (HP:0007707)2.63165802
55Atonic seizures (HP:0010819)2.62500574
56Methylmalonic aciduria (HP:0012120)2.62362731
57Generalized aminoaciduria (HP:0002909)2.62276483
58Facial hemangioma (HP:0000329)2.61593712
59Medial flaring of the eyebrow (HP:0010747)2.60418292
60Acute necrotizing encephalopathy (HP:0006965)2.59778816
61Short tibia (HP:0005736)2.59368890
62Abnormality of glycine metabolism (HP:0010895)2.59210312
63Abnormality of serine family amino acid metabolism (HP:0010894)2.59210312
64Hypoglycemic coma (HP:0001325)2.57206200
65Abnormality of methionine metabolism (HP:0010901)2.55054761
66Hyperglycinuria (HP:0003108)2.53886174
67Failure to thrive in infancy (HP:0001531)2.49857610
68Spontaneous abortion (HP:0005268)2.49766948
69Septo-optic dysplasia (HP:0100842)2.47298088
70Azoospermia (HP:0000027)2.45159193
71Generalized tonic-clonic seizures (HP:0002069)2.44840937
72Specific learning disability (HP:0001328)2.44531372
73Microvesicular hepatic steatosis (HP:0001414)2.40592477
74Colon cancer (HP:0003003)2.38682823
75Abnormal respiratory epithelium morphology (HP:0012253)2.36301976
76Abnormal respiratory motile cilium morphology (HP:0005938)2.36301976
77Gout (HP:0001997)2.36283426
78Stomatitis (HP:0010280)2.36028562
79Abnormal spermatogenesis (HP:0008669)2.35947419
80Visual hallucinations (HP:0002367)2.35184965
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34149836
82Urinary bladder sphincter dysfunction (HP:0002839)2.34041190
83Cerebral edema (HP:0002181)2.33873601
84Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29554519
85Abnormal protein glycosylation (HP:0012346)2.29407561
86Abnormal glycosylation (HP:0012345)2.29407561
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29407561
88Abnormal protein N-linked glycosylation (HP:0012347)2.29407561
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.27319987
90Increased muscle lipid content (HP:0009058)2.27022531
91Absence seizures (HP:0002121)2.25495105
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25320347
93Rhinitis (HP:0012384)2.25207997
94Nephrogenic diabetes insipidus (HP:0009806)2.22923181
95Abnormality of vitamin B metabolism (HP:0004340)2.22799216
96Abnormality of homocysteine metabolism (HP:0010919)2.21804878
97Homocystinuria (HP:0002156)2.21804878
98Congenital, generalized hypertrichosis (HP:0004540)2.21211560
99Agitation (HP:0000713)2.20958615
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.20531547
101Absent/shortened dynein arms (HP:0200106)2.20531547
102Progressive macrocephaly (HP:0004481)2.20141954
103Abnormal mitochondria in muscle tissue (HP:0008316)2.19847710
104Abnormality of the clitoris (HP:0000056)2.18273411
105Febrile seizures (HP:0002373)2.18128951
106Hyperventilation (HP:0002883)2.17081604
107Petechiae (HP:0000967)2.16724038
108Abnormal gallbladder physiology (HP:0012438)2.14287746
109Cholecystitis (HP:0001082)2.14287746
110Hepatocellular necrosis (HP:0001404)2.12605087
111Limb hypertonia (HP:0002509)2.11545481
112Aplasia/Hypoplasia of the tibia (HP:0005772)2.11303710
113Genital tract atresia (HP:0001827)2.10684106
114Esotropia (HP:0000565)2.10676933
115Posterior subcapsular cataract (HP:0007787)2.10230448
116Vaginal atresia (HP:0000148)2.10021363
117Hypokinesia (HP:0002375)2.08909906
118Acute hepatic failure (HP:0006554)2.08085411
119Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07673708
120Dicarboxylic aciduria (HP:0003215)2.07673708
121Morphological abnormality of the pyramidal tract (HP:0002062)2.05546477
122Megaloblastic anemia (HP:0001889)2.05449812
123Genetic anticipation (HP:0003743)2.04319685
124Oral leukoplakia (HP:0002745)2.04059611
125Hyperthyroidism (HP:0000836)2.04053897
126Renal cortical cysts (HP:0000803)2.02760249
127Abnormality of the labia (HP:0000058)2.02359677
128Absent septum pellucidum (HP:0001331)2.00738807
1293-Methylglutaconic aciduria (HP:0003535)1.99455076
130Mesomelia (HP:0003027)1.99262733
131Chronic diarrhea (HP:0002028)1.98550916
132Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97619381
133Impaired vibratory sensation (HP:0002495)1.96480938
134Lactic acidosis (HP:0003128)1.94801467
135Acute encephalopathy (HP:0006846)1.94224497
136Postaxial hand polydactyly (HP:0001162)1.94038379
137Urinary urgency (HP:0000012)1.93666944
138Large hands (HP:0001176)1.93366683
139Distal lower limb amyotrophy (HP:0008944)1.92788399
140Pancreatic cysts (HP:0001737)1.92467597
141Abnormality of binocular vision (HP:0011514)1.91624142
142Diplopia (HP:0000651)1.91624142
143Dysdiadochokinesis (HP:0002075)1.90640393
144Exercise intolerance (HP:0003546)1.89439761
145Congenital stationary night blindness (HP:0007642)1.88958015
146Large for gestational age (HP:0001520)1.86682893
147Pheochromocytoma (HP:0002666)1.86374594
148Occipital encephalocele (HP:0002085)1.85993862
149Neuronal loss in central nervous system (HP:0002529)1.85988776
150Lower limb amyotrophy (HP:0007210)1.85764460
151Lethargy (HP:0001254)1.84325717
152Mitochondrial inheritance (HP:0001427)1.84047439
153Male pseudohermaphroditism (HP:0000037)1.83048978
154Furrowed tongue (HP:0000221)1.82947772
155Anencephaly (HP:0002323)1.82640055
156Drooling (HP:0002307)1.82422819
157Excessive salivation (HP:0003781)1.82422819
158Hyperphosphaturia (HP:0003109)1.81779693
159Abnormality of the septum pellucidum (HP:0007375)1.79948365
160Action tremor (HP:0002345)1.79933064
161Prolonged bleeding time (HP:0003010)1.79760652
162Abnormality of sulfur amino acid metabolism (HP:0004339)1.78977620
163Leukodystrophy (HP:0002415)1.78946342
164Spastic gait (HP:0002064)1.78641947
165Aplasia/hypoplasia of the humerus (HP:0006507)1.78614354
166Tubulointerstitial nephritis (HP:0001970)1.78201579
167Hemiparesis (HP:0001269)1.77742766
168Sclerocornea (HP:0000647)1.75777331
169Neuroendocrine neoplasm (HP:0100634)1.75703888
170Lower limb muscle weakness (HP:0007340)1.75342343
171Cystic liver disease (HP:0006706)1.72931347
172Respiratory failure (HP:0002878)1.72713450
173Abnormality of the vitamin B12 metabolism (HP:0004341)1.72393719
174Oligomenorrhea (HP:0000876)1.71412756
175Abnormality of chromosome stability (HP:0003220)1.71255195
176Optic disc pallor (HP:0000543)1.70943986
177Short humerus (HP:0005792)1.70430016
178Impulsivity (HP:0100710)1.69909228
179Hypomagnesemia (HP:0002917)1.69468001
180Postural tremor (HP:0002174)1.68297996
181Abnormality of the anterior horn cell (HP:0006802)1.67815514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK26.64141866
2CAMK1D6.24331618
3CAMK1G5.35819688
4BMPR23.51564753
5VRK23.24914763
6PINK13.00920332
7CASK2.87301751
8ERBB32.85891110
9NTRK22.70380365
10CAMKK12.69196527
11NTRK32.63021170
12TAF12.48483296
13STK392.43569733
14MST42.40786791
15STK162.31143403
16MAP3K122.23143551
17PNCK2.20487986
18NUAK12.19679746
19PRKD32.18038458
20TIE12.12642757
21BUB12.12602270
22BMPR1B2.10217612
23MARK11.94656262
24FRK1.89502614
25MAP3K91.86381653
26WNK31.79900310
27EIF2AK31.76026942
28DYRK31.74909348
29BCKDK1.71937934
30MKNK21.68726535
31PBK1.68150652
32ZAK1.68094951
33CDC71.66282389
34VRK11.61815375
35TNK21.53671911
36MAP3K41.50864701
37CSNK1G11.45261243
38EIF2AK11.43268568
39SIK31.43126638
40SIK21.41224904
41NEK11.40992054
42WNK41.40835565
43BRSK21.33950426
44LIMK11.33869778
45MAP4K21.33794235
46CAMK41.33553225
47GRK71.32823024
48CDK91.32714521
49LATS21.27277736
50TRIM281.26262811
51TSSK61.21904864
52KDR1.21220765
53CAMK11.17587651
54TAOK31.13659330
55MAP2K71.11453916
56KSR11.10448389
57MINK11.09453944
58CSNK1A1L1.08634263
59PAK31.06448494
60PAK61.05605307
61ADRBK11.01368699
62MKNK11.01067782
63OXSR11.00260488
64TTK0.98958898
65ALK0.93316847
66UHMK10.92090466
67KSR20.89989173
68AURKA0.87608297
69PLK40.84378328
70TEC0.83541590
71MAPK130.82805787
72PLK20.82512490
73CAMK2A0.82040106
74PLK30.81598063
75CDK80.80730526
76CDK70.80684073
77PRKCG0.80563836
78TRPM70.80443719
79RIPK40.78979452
80NME10.77463750
81MAP2K40.77128353
82NEK60.75009008
83BRAF0.74772584
84STK240.74431004
85EIF2AK20.74027703
86PLK10.73669815
87DYRK20.70853297
88PHKG10.70528308
89PHKG20.70528308
90NEK90.68984211
91CDK50.68832977
92MAP3K130.67180492
93DDR20.63111268
94STK30.62622269
95ATR0.60583811
96ARAF0.60321709
97GRK50.58934478
98JAK30.58384538
99MUSK0.57850348
100CAMK2B0.57699776
101CDK140.57589004
102ILK0.57074710
103PIM10.53922098
104CSNK1A10.53718005
105CDK150.50933155
106CDK180.50716710
107ACVR1B0.50444658
108ROCK20.49891556
109CHEK20.49426947
110NEK20.48814440
111CDK11A0.48754702
112TGFBR10.48324536
113CDK190.48249469
114DAPK10.48147353
115CSNK1G20.47993430
116SCYL20.47020183
117CSNK2A20.46948825
118TAOK10.46779720
119AKT30.46706255
120CDC42BPA0.46554512
121ATM0.45408108
122TESK10.43911860
123SRPK10.42429457
124CAMK2D0.42384849
125WNK10.41773078
126FER0.41612882
127PRKCE0.40522192
128RAF10.40187559
129BCR0.37841545
130EPHA40.36836617
131CSNK1G30.36370988
132AURKB0.34155546
133BRSK10.33670961
134ADRBK20.33536144
135SIK10.32327015
136CSNK2A10.32252336
137NTRK10.32092794
138PRKCI0.31916966
139FES0.31268302
140MYLK0.31107168
141MARK30.30826872
142CSNK1D0.30604083
143MARK20.29182695
144ITK0.27168223
145TESK20.26771348
146TXK0.26733430
147INSRR0.25225217
148PASK0.24942294
149CAMK2G0.24451708
150GRK10.24133955
151DYRK1A0.24046845
152MOS0.23534678
153LRRK20.23069361
154SGK10.23064204
155PDK20.22509045
156PDK30.22449725
157PDK40.22449725
158PRKACB0.22429922
159ERBB40.22324779
160PRKACA0.21683268
161DAPK20.21246286
162RPS6KA60.20430393
163TNIK0.20145965
164CHEK10.20011144
165CSNK1E0.20008225
166RPS6KC10.19674705
167RPS6KL10.19674705
168STK110.19272938

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.09678808
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18501637
3Oxidative phosphorylation_Homo sapiens_hsa001903.13328369
4Collecting duct acid secretion_Homo sapiens_hsa049662.97357139
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.87786044
6Propanoate metabolism_Homo sapiens_hsa006402.69114252
7Basal transcription factors_Homo sapiens_hsa030222.54611660
8Protein export_Homo sapiens_hsa030602.48007970
9GABAergic synapse_Homo sapiens_hsa047272.43172270
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40792419
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26448698
12Parkinsons disease_Homo sapiens_hsa050122.18529279
13Nucleotide excision repair_Homo sapiens_hsa034202.13533294
14Morphine addiction_Homo sapiens_hsa050322.08268953
15Circadian entrainment_Homo sapiens_hsa047132.08069378
16Olfactory transduction_Homo sapiens_hsa047402.06494865
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04673168
18DNA replication_Homo sapiens_hsa030302.04430335
19Huntingtons disease_Homo sapiens_hsa050162.02775838
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02661973
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01640253
22Folate biosynthesis_Homo sapiens_hsa007902.00729971
23Serotonergic synapse_Homo sapiens_hsa047261.98567457
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.95410489
25Glutamatergic synapse_Homo sapiens_hsa047241.93372651
26Dopaminergic synapse_Homo sapiens_hsa047281.90838980
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.90213734
28Alzheimers disease_Homo sapiens_hsa050101.90001759
29Vitamin digestion and absorption_Homo sapiens_hsa049771.84879322
30Caffeine metabolism_Homo sapiens_hsa002321.82646011
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81582214
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81081425
33RNA degradation_Homo sapiens_hsa030181.78500880
34Salivary secretion_Homo sapiens_hsa049701.74715456
35Long-term depression_Homo sapiens_hsa047301.74537937
36Cardiac muscle contraction_Homo sapiens_hsa042601.72284783
37Proteasome_Homo sapiens_hsa030501.70980264
38Cholinergic synapse_Homo sapiens_hsa047251.70896946
39Taste transduction_Homo sapiens_hsa047421.70326037
40Fatty acid elongation_Homo sapiens_hsa000621.67450320
41Vibrio cholerae infection_Homo sapiens_hsa051101.63459252
42Amphetamine addiction_Homo sapiens_hsa050311.61463699
43Fanconi anemia pathway_Homo sapiens_hsa034601.60379812
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54986695
45Cocaine addiction_Homo sapiens_hsa050301.54071181
46Long-term potentiation_Homo sapiens_hsa047201.50588197
47Base excision repair_Homo sapiens_hsa034101.47916088
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41010724
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37905934
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35590054
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33392608
52Oxytocin signaling pathway_Homo sapiens_hsa049211.32485973
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29117546
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28933440
55RNA transport_Homo sapiens_hsa030131.28473123
56Purine metabolism_Homo sapiens_hsa002301.28054343
57Fatty acid biosynthesis_Homo sapiens_hsa000611.26378939
58One carbon pool by folate_Homo sapiens_hsa006701.25099844
59Spliceosome_Homo sapiens_hsa030401.24467918
60Peroxisome_Homo sapiens_hsa041461.23985631
61Insulin secretion_Homo sapiens_hsa049111.21952518
62Fatty acid metabolism_Homo sapiens_hsa012121.20167235
63Pyruvate metabolism_Homo sapiens_hsa006201.20006027
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19510285
65Type I diabetes mellitus_Homo sapiens_hsa049401.19102974
66Butanoate metabolism_Homo sapiens_hsa006501.17847104
67Pyrimidine metabolism_Homo sapiens_hsa002401.15077535
68Non-homologous end-joining_Homo sapiens_hsa034501.13231370
69Selenocompound metabolism_Homo sapiens_hsa004501.11454053
70Axon guidance_Homo sapiens_hsa043601.10713488
71Gastric acid secretion_Homo sapiens_hsa049711.10622959
72Gap junction_Homo sapiens_hsa045401.07145453
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06984127
74Calcium signaling pathway_Homo sapiens_hsa040201.02783148
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02487549
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01056049
77Glutathione metabolism_Homo sapiens_hsa004801.00618678
78Cyanoamino acid metabolism_Homo sapiens_hsa004601.00001224
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99292358
80Cell cycle_Homo sapiens_hsa041100.94952382
81RNA polymerase_Homo sapiens_hsa030200.93641757
82Homologous recombination_Homo sapiens_hsa034400.93312956
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93029561
84Melanogenesis_Homo sapiens_hsa049160.91836685
85Rheumatoid arthritis_Homo sapiens_hsa053230.89669834
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89177330
87Renin secretion_Homo sapiens_hsa049240.88344989
88Phototransduction_Homo sapiens_hsa047440.87334487
89Fatty acid degradation_Homo sapiens_hsa000710.87328534
90Sulfur relay system_Homo sapiens_hsa041220.85074637
91Arginine biosynthesis_Homo sapiens_hsa002200.85019236
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83382139
93Primary immunodeficiency_Homo sapiens_hsa053400.83157682
94Metabolic pathways_Homo sapiens_hsa011000.81168887
95Tryptophan metabolism_Homo sapiens_hsa003800.79771190
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79717498
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77571155
98Phagosome_Homo sapiens_hsa041450.77459530
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76306603
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71484727
101Oocyte meiosis_Homo sapiens_hsa041140.71349877
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67161189
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65871193
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65652458
105Thyroid hormone synthesis_Homo sapiens_hsa049180.63922909
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62722764
107Estrogen signaling pathway_Homo sapiens_hsa049150.61961237
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61613118
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60960503
110Phenylalanine metabolism_Homo sapiens_hsa003600.59320223
111Steroid biosynthesis_Homo sapiens_hsa001000.55478973
112cAMP signaling pathway_Homo sapiens_hsa040240.55366195
113Dilated cardiomyopathy_Homo sapiens_hsa054140.55233979
114Alcoholism_Homo sapiens_hsa050340.53158124
115Ras signaling pathway_Homo sapiens_hsa040140.50163738
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49716938
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49418730
118Linoleic acid metabolism_Homo sapiens_hsa005910.48638947
119GnRH signaling pathway_Homo sapiens_hsa049120.48172531
120Prion diseases_Homo sapiens_hsa050200.48014381
121ABC transporters_Homo sapiens_hsa020100.47929555
122Sulfur metabolism_Homo sapiens_hsa009200.47813662
123Histidine metabolism_Homo sapiens_hsa003400.47715574
124Ribosome_Homo sapiens_hsa030100.46335382
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45787999
126Retinol metabolism_Homo sapiens_hsa008300.45775786
127Tight junction_Homo sapiens_hsa045300.45726638
128Dorso-ventral axis formation_Homo sapiens_hsa043200.45721811
129mRNA surveillance pathway_Homo sapiens_hsa030150.45323868
130p53 signaling pathway_Homo sapiens_hsa041150.45228142
131Biosynthesis of amino acids_Homo sapiens_hsa012300.44304096
132Glioma_Homo sapiens_hsa052140.44140581
133Arginine and proline metabolism_Homo sapiens_hsa003300.43987322
134Carbon metabolism_Homo sapiens_hsa012000.43760272
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43279019
136Type II diabetes mellitus_Homo sapiens_hsa049300.42631888
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42059518
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41850189
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41256721
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40587528
141Arachidonic acid metabolism_Homo sapiens_hsa005900.40197453
142Hippo signaling pathway_Homo sapiens_hsa043900.39861711
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.39556362
144Hedgehog signaling pathway_Homo sapiens_hsa043400.38046360
145Vitamin B6 metabolism_Homo sapiens_hsa007500.35523199
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35331816
147MAPK signaling pathway_Homo sapiens_hsa040100.34841595
148Melanoma_Homo sapiens_hsa052180.34228261
149Mismatch repair_Homo sapiens_hsa034300.34078099
150Glucagon signaling pathway_Homo sapiens_hsa049220.32987326
151ErbB signaling pathway_Homo sapiens_hsa040120.32886999
152Rap1 signaling pathway_Homo sapiens_hsa040150.30598226
153Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28772904
154Regulation of autophagy_Homo sapiens_hsa041400.28725143
155beta-Alanine metabolism_Homo sapiens_hsa004100.28449288
156Wnt signaling pathway_Homo sapiens_hsa043100.27320781
157Tyrosine metabolism_Homo sapiens_hsa003500.27180913
158cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27077472
159Nitrogen metabolism_Homo sapiens_hsa009100.26319696
160Platelet activation_Homo sapiens_hsa046110.24858487
161Ovarian steroidogenesis_Homo sapiens_hsa049130.24027481
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23215253
163Hematopoietic cell lineage_Homo sapiens_hsa046400.19147339

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