RLN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA modification (GO:0000154)4.70623273
2chromatin remodeling at centromere (GO:0031055)4.47571613
3CENP-A containing nucleosome assembly (GO:0034080)4.41446187
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.21395152
5rRNA methylation (GO:0031167)4.19837469
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.17108831
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.10684788
8regulation of mitotic spindle checkpoint (GO:1903504)4.10684788
9proteasome assembly (GO:0043248)4.04366910
10DNA double-strand break processing (GO:0000729)4.02940450
11regulation of mitochondrial translation (GO:0070129)3.98728076
12protein neddylation (GO:0045116)3.94481401
13chaperone-mediated protein transport (GO:0072321)3.91815710
14telomere maintenance via semi-conservative replication (GO:0032201)3.88554933
15ribosomal small subunit assembly (GO:0000028)3.88100855
16DNA strand elongation involved in DNA replication (GO:0006271)3.87251314
17L-serine metabolic process (GO:0006563)3.74462949
18purine nucleobase biosynthetic process (GO:0009113)3.71951026
19histone exchange (GO:0043486)3.68024860
20establishment of integrated proviral latency (GO:0075713)3.67099349
21respiratory chain complex IV assembly (GO:0008535)3.65108810
22mitochondrial respiratory chain complex assembly (GO:0033108)3.65083967
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64658089
24kinetochore organization (GO:0051383)3.64629267
25somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63658061
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.63658061
27DNA strand elongation (GO:0022616)3.60665537
28protein complex biogenesis (GO:0070271)3.60282699
29IMP biosynthetic process (GO:0006188)3.59103058
30DNA replication checkpoint (GO:0000076)3.58617534
31ATP synthesis coupled proton transport (GO:0015986)3.58262726
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58262726
33water-soluble vitamin biosynthetic process (GO:0042364)3.56788883
34nucleobase biosynthetic process (GO:0046112)3.51960158
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49675356
36regulation of helicase activity (GO:0051095)3.48893462
37lactate metabolic process (GO:0006089)3.42646551
38DNA replication-independent nucleosome assembly (GO:0006336)3.42160399
39DNA replication-independent nucleosome organization (GO:0034724)3.42160399
40pseudouridine synthesis (GO:0001522)3.40757226
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37690431
42mitotic recombination (GO:0006312)3.36733765
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36713398
44kinetochore assembly (GO:0051382)3.33340168
45cytochrome complex assembly (GO:0017004)3.32825949
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.32184172
47termination of RNA polymerase III transcription (GO:0006386)3.32184172
48telomere maintenance via recombination (GO:0000722)3.31749622
49spliceosomal snRNP assembly (GO:0000387)3.31685300
50mitotic metaphase plate congression (GO:0007080)3.29234785
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27514714
52negative regulation of ligase activity (GO:0051352)3.27514714
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25669339
54GMP metabolic process (GO:0046037)3.25399567
55telomere maintenance via telomere lengthening (GO:0010833)3.25230783
56folic acid-containing compound biosynthetic process (GO:0009396)3.24044953
57nucleotide-excision repair, DNA gap filling (GO:0006297)3.23646514
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.23118006
59NADH dehydrogenase complex assembly (GO:0010257)3.23118006
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23118006
61IMP metabolic process (GO:0046040)3.20277907
62oxidative phosphorylation (GO:0006119)3.18032134
63aldehyde catabolic process (GO:0046185)3.17388963
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14199605
65translational termination (GO:0006415)3.11360638
66viral transcription (GO:0019083)3.10769858
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10163380
68ribosome assembly (GO:0042255)3.09640198
69negative regulation of DNA-dependent DNA replication (GO:2000104)3.08666710
70DNA damage response, detection of DNA damage (GO:0042769)3.08347168
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07317905
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07317905
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07317905
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.07317905
75negative regulation of sister chromatid segregation (GO:0033046)3.07317905
76peptidyl-histidine modification (GO:0018202)3.06976242
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05920508
78DNA catabolic process, exonucleolytic (GO:0000738)3.04466861
79cotranslational protein targeting to membrane (GO:0006613)3.03963487
80negative regulation of chromosome segregation (GO:0051985)3.01641302
81DNA deamination (GO:0045006)2.99972267
82translation (GO:0006412)2.99514249
83protein targeting to ER (GO:0045047)2.99278980
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.99145613
85mitotic spindle checkpoint (GO:0071174)2.98713858
86spindle checkpoint (GO:0031577)2.98542579
87pteridine-containing compound biosynthetic process (GO:0042559)2.96674868
88formation of translation preinitiation complex (GO:0001731)2.93190441
89serine family amino acid biosynthetic process (GO:0009070)2.92845057
90mitochondrial RNA metabolic process (GO:0000959)2.92656215
91metaphase plate congression (GO:0051310)2.91874090
92establishment of viral latency (GO:0019043)2.90986868
93ribosomal large subunit biogenesis (GO:0042273)2.89655648
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89358847
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89358847
96rRNA processing (GO:0006364)2.88082463
97establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87904915
98respiratory electron transport chain (GO:0022904)2.84813316
99protein targeting to mitochondrion (GO:0006626)2.84619043
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83711126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25681438
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71615926
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.04892393
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.92325252
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90956749
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.90142897
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.73133822
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.20239803
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17398250
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10744809
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04981283
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97300142
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.91113934
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86300853
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86091210
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73685376
17VDR_23849224_ChIP-Seq_CD4+_Human2.69909490
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64785485
19FOXP3_21729870_ChIP-Seq_TREG_Human2.60429553
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59322035
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58064252
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57991748
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35497333
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33038687
25ELK1_19687146_ChIP-ChIP_HELA_Human2.32835544
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21624992
27DCP1A_22483619_ChIP-Seq_HELA_Human2.16712400
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15495889
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.11007432
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08683421
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06778840
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05400097
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04294884
34TTF2_22483619_ChIP-Seq_HELA_Human2.01159234
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.01115107
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93078693
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.90918944
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89862070
39GABP_19822575_ChIP-Seq_HepG2_Human1.87455039
40XRN2_22483619_ChIP-Seq_HELA_Human1.85614123
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.83162319
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81893563
43AR_21909140_ChIP-Seq_LNCAP_Human1.77775942
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75920112
45IRF1_19129219_ChIP-ChIP_H3396_Human1.72522421
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70661155
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67830771
48* MYC_18940864_ChIP-ChIP_HL60_Human1.66731822
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62939561
50ZNF274_21170338_ChIP-Seq_K562_Hela1.62581426
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59580132
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52077770
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51883537
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45431912
55EWS_26573619_Chip-Seq_HEK293_Human1.44083526
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37190805
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34864214
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33427427
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32238381
60KDM5A_27292631_Chip-Seq_BREAST_Human1.29194464
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.28308444
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.26108975
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23408855
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22864947
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.21324595
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19690384
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18523538
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15445770
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14851787
70FUS_26573619_Chip-Seq_HEK293_Human1.09935473
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04341474
72IGF1R_20145208_ChIP-Seq_DFB_Human1.01980152
73CIITA_25753668_ChIP-Seq_RAJI_Human1.01034519
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99421949
75TP63_19390658_ChIP-ChIP_HaCaT_Human0.97915643
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96807106
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96772124
78SALL1_21062744_ChIP-ChIP_HESCs_Human0.95467862
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94975941
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.94688777
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94026318
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92686405
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90590616
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.87899484
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86503696
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86100153
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82501829
88TAF15_26573619_Chip-Seq_HEK293_Human0.81594495
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81505145
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81051261
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80910063
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78213330
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78002749
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77404627
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.77404627
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76988367
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75158973
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74720439
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71927181
100ELF5_23300383_ChIP-Seq_T47D_Human0.71777648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.36369066
2MP0010094_abnormal_chromosome_stability3.95636844
3MP0008058_abnormal_DNA_repair3.57473389
4MP0008057_abnormal_DNA_replication3.55908502
5MP0002638_abnormal_pupillary_reflex3.34464019
6MP0004957_abnormal_blastocyst_morpholog3.10061110
7MP0003111_abnormal_nucleus_morphology3.08868605
8MP0003136_yellow_coat_color2.90498353
9MP0003806_abnormal_nucleotide_metabolis2.85054871
10MP0008932_abnormal_embryonic_tissue2.66741682
11MP0003077_abnormal_cell_cycle2.65060655
12MP0003941_abnormal_skin_development2.54561025
13MP0008007_abnormal_cellular_replicative2.50450261
14MP0001764_abnormal_homeostasis2.27275305
15MP0006072_abnormal_retinal_apoptosis2.25141252
16MP0008877_abnormal_DNA_methylation2.24770392
17MP0002822_catalepsy2.01141689
18MP0001188_hyperpigmentation2.00165580
19MP0010234_abnormal_vibrissa_follicle1.88992839
20MP0003787_abnormal_imprinting1.87861493
21MP0001529_abnormal_vocalization1.86959989
22MP0009379_abnormal_foot_pigmentation1.86147605
23MP0005379_endocrine/exocrine_gland_phen1.83307971
24MP0003123_paternal_imprinting1.80576665
25MP0002938_white_spotting1.70242318
26MP0003786_premature_aging1.68857707
27MP0006292_abnormal_olfactory_placode1.68395109
28MP0001293_anophthalmia1.66852717
29MP0003718_maternal_effect1.64532531
30MP0002234_abnormal_pharynx_morphology1.57397351
31MP0004133_heterotaxia1.55883912
32MP0005075_abnormal_melanosome_morpholog1.49695575
33MP0005253_abnormal_eye_physiology1.47156008
34MP0002837_dystrophic_cardiac_calcinosis1.38287333
35MP0003186_abnormal_redox_activity1.34252821
36MP0006036_abnormal_mitochondrial_physio1.32656513
37MP0006035_abnormal_mitochondrial_morpho1.31255917
38MP0001984_abnormal_olfaction1.26563696
39MP0000350_abnormal_cell_proliferation1.25964322
40MP0001919_abnormal_reproductive_system1.25928958
41MP0002163_abnormal_gland_morphology1.25490500
42MP0002160_abnormal_reproductive_system1.25304996
43MP0003121_genomic_imprinting1.25280536
44MP0001730_embryonic_growth_arrest1.24355814
45MP0009697_abnormal_copulation1.21635319
46MP0005394_taste/olfaction_phenotype1.19837745
47MP0005499_abnormal_olfactory_system1.19837745
48MP0003122_maternal_imprinting1.18236764
49MP0005389_reproductive_system_phenotype1.17734670
50MP0002254_reproductive_system_inflammat1.14993492
51MP0002210_abnormal_sex_determination1.14381419
52MP0009333_abnormal_splenocyte_physiolog1.10374696
53MP0002396_abnormal_hematopoietic_system1.09916192
54MP0003567_abnormal_fetal_cardiomyocyte1.09265991
55MP0000313_abnormal_cell_death1.03652504
56MP0001929_abnormal_gametogenesis1.00398462
57MP0003011_delayed_dark_adaptation1.00148072
58MP0001727_abnormal_embryo_implantation1.00081230
59MP0001145_abnormal_male_reproductive0.98069450
60MP0002102_abnormal_ear_morphology0.97329196
61MP0001697_abnormal_embryo_size0.96336302
62MP0005645_abnormal_hypothalamus_physiol0.95707400
63MP0010307_abnormal_tumor_latency0.95133937
64MP0002090_abnormal_vision0.94090527
65MP0005551_abnormal_eye_electrophysiolog0.92810886
66MP0003937_abnormal_limbs/digits/tail_de0.92416817
67MP0008789_abnormal_olfactory_epithelium0.86483820
68MP0000653_abnormal_sex_gland0.86260993
69MP0008872_abnormal_physiological_respon0.85213740
70MP0002085_abnormal_embryonic_tissue0.83873271
71MP0005266_abnormal_metabolism0.81891031
72MP0003936_abnormal_reproductive_system0.81398746
73MP0002019_abnormal_tumor_incidence0.80763805
74MP0000049_abnormal_middle_ear0.76735468
75MP0005084_abnormal_gallbladder_morpholo0.75929694
76MP0000358_abnormal_cell_content/0.74257142
77MP0000372_irregular_coat_pigmentation0.73024528
78MP0002751_abnormal_autonomic_nervous0.71131470
79MP0004215_abnormal_myocardial_fiber0.70863404
80MP0005332_abnormal_amino_acid0.70705068
81MP0005248_abnormal_Harderian_gland0.70249549
82MP0003137_abnormal_impulse_conducting0.69960203
83MP0000579_abnormal_nail_morphology0.69912174
84MP0000631_abnormal_neuroendocrine_gland0.69805910
85MP0003698_abnormal_male_reproductive0.69671227
86MP0001186_pigmentation_phenotype0.69531623
87MP0002084_abnormal_developmental_patter0.69519974
88MP0002080_prenatal_lethality0.69024766
89MP0005171_absent_coat_pigmentation0.67954741
90MP0002796_impaired_skin_barrier0.66511247
91MP0003890_abnormal_embryonic-extraembry0.65361439
92MP0001661_extended_life_span0.64395420
93MP0000427_abnormal_hair_cycle0.64265114
94MP0000703_abnormal_thymus_morphology0.63317236
95MP0002111_abnormal_tail_morphology0.62381718
96MP0010678_abnormal_skin_adnexa0.62107651
97MP0005395_other_phenotype0.61970993
98MP0001324_abnormal_eye_pigmentation0.61470951
99MP0009672_abnormal_birth_weight0.61178281
100MP0005391_vision/eye_phenotype0.61156165

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.31549568
2Acute necrotizing encephalopathy (HP:0006965)4.04456636
3Acute encephalopathy (HP:0006846)3.96190147
4Increased hepatocellular lipid droplets (HP:0006565)3.82771043
5Lipid accumulation in hepatocytes (HP:0006561)3.67910080
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.65340975
7Abnormal mitochondria in muscle tissue (HP:0008316)3.63497089
8Progressive macrocephaly (HP:0004481)3.54829997
9Mitochondrial inheritance (HP:0001427)3.47713042
10Chromsome breakage (HP:0040012)3.33639129
11Increased CSF lactate (HP:0002490)3.22767055
12Abnormality of the labia minora (HP:0012880)3.21457191
13True hermaphroditism (HP:0010459)3.19080561
14Renal Fanconi syndrome (HP:0001994)3.07864294
15Cerebral edema (HP:0002181)3.03709432
16Hyperglycinemia (HP:0002154)2.93991287
17Meckel diverticulum (HP:0002245)2.88919344
18Microvesicular hepatic steatosis (HP:0001414)2.87338765
19Abnormality of methionine metabolism (HP:0010901)2.73537454
20Abnormality of the ileum (HP:0001549)2.68692648
21Hepatocellular necrosis (HP:0001404)2.66221305
22Congenital malformation of the right heart (HP:0011723)2.64728444
23Double outlet right ventricle (HP:0001719)2.64728444
24Abnormality of the preputium (HP:0100587)2.62136810
25Reticulocytopenia (HP:0001896)2.58925379
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.54419045
27Pancreatic islet-cell hyperplasia (HP:0004510)2.49913438
28Hepatic necrosis (HP:0002605)2.49879586
29Pancytopenia (HP:0001876)2.47522477
30Neoplasm of the adrenal gland (HP:0100631)2.44629540
31IgM deficiency (HP:0002850)2.44621773
32Abnormality of chromosome stability (HP:0003220)2.43522383
33Neoplasm of the adrenal cortex (HP:0100641)2.43489609
34Birth length less than 3rd percentile (HP:0003561)2.42718742
35Macrocytic anemia (HP:0001972)2.42115564
36Increased serum lactate (HP:0002151)2.41404246
37Lactic acidosis (HP:0003128)2.40419063
38Increased intramyocellular lipid droplets (HP:0012240)2.39602935
39Abnormality of glycine metabolism (HP:0010895)2.31915950
40Abnormality of serine family amino acid metabolism (HP:0010894)2.31915950
41Hyperglycinuria (HP:0003108)2.31070834
42Nephroblastoma (Wilms tumor) (HP:0002667)2.28718249
43Abnormal number of erythroid precursors (HP:0012131)2.28007580
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27273531
45Sclerocornea (HP:0000647)2.26804236
46Methylmalonic acidemia (HP:0002912)2.23460420
47Pancreatic fibrosis (HP:0100732)2.23373540
48Hypoglycemic seizures (HP:0002173)2.21905088
49Aplastic anemia (HP:0001915)2.21483604
50Leukodystrophy (HP:0002415)2.21017886
51Multiple enchondromatosis (HP:0005701)2.19826005
52Pancreatic cysts (HP:0001737)2.19318400
53Abnormality of cells of the erythroid lineage (HP:0012130)2.16556528
54Hyperinsulinemic hypoglycemia (HP:0000825)2.13970289
55Exercise intolerance (HP:0003546)2.10823916
56Abnormal lung lobation (HP:0002101)2.10736521
57Respiratory failure (HP:0002878)2.09427731
58Abnormality of renal resorption (HP:0011038)2.08161523
59Embryonal renal neoplasm (HP:0011794)2.08096203
60Increased muscle lipid content (HP:0009058)2.07806432
61Abnormality of serum amino acid levels (HP:0003112)2.05798278
62Lethargy (HP:0001254)2.05789237
63Breast carcinoma (HP:0003002)2.05084217
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00810842
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00810842
66Type I transferrin isoform profile (HP:0003642)1.99250030
67Exertional dyspnea (HP:0002875)1.98464486
68Megaloblastic anemia (HP:0001889)1.96576311
69Small intestinal stenosis (HP:0012848)1.96328930
70Duodenal stenosis (HP:0100867)1.96328930
71Abnormal protein glycosylation (HP:0012346)1.95363568
72Abnormal glycosylation (HP:0012345)1.95363568
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95363568
74Abnormal protein N-linked glycosylation (HP:0012347)1.95363568
75Respiratory difficulties (HP:0002880)1.95155961
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93481988
77Squamous cell carcinoma (HP:0002860)1.90892397
78Rhabdomyosarcoma (HP:0002859)1.89657275
79Septo-optic dysplasia (HP:0100842)1.89401999
80Optic disc pallor (HP:0000543)1.88260390
81Cerebral hypomyelination (HP:0006808)1.87308322
82Abnormality of the anterior horn cell (HP:0006802)1.86240331
83Degeneration of anterior horn cells (HP:0002398)1.86240331
84Ovarian neoplasm (HP:0100615)1.85409310
85Sensory axonal neuropathy (HP:0003390)1.84985048
86Methylmalonic aciduria (HP:0012120)1.84930099
87Male pseudohermaphroditism (HP:0000037)1.84467358
88Sloping forehead (HP:0000340)1.84419728
89Triphalangeal thumb (HP:0001199)1.84260119
90Abnormality of the duodenum (HP:0002246)1.81330181
91Increased serum pyruvate (HP:0003542)1.80303213
92Aplasia/hypoplasia of the uterus (HP:0008684)1.80081755
93Abnormality of sulfur amino acid metabolism (HP:0004339)1.79814331
94Sex reversal (HP:0012245)1.79274005
95Abnormal sex determination (HP:0012244)1.79274005
96Limb hypertonia (HP:0002509)1.77300130
97Chronic bronchitis (HP:0004469)1.77266088
98Clubbing of toes (HP:0100760)1.75922774
99Abnormality of endocrine pancreas physiology (HP:0012093)1.72857437
100Abnormality of the pancreatic islet cells (HP:0006476)1.72857437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.38852118
2BUB14.13307509
3MAP4K23.39879821
4ZAK3.35534921
5TAF13.16450114
6MST43.02387867
7NUAK12.86373852
8CDC72.77720048
9VRK12.59796266
10STK162.49395282
11PLK32.29173768
12MKNK12.21336069
13MKNK22.16665752
14PASK2.14634377
15PBK2.13188561
16TTK2.10368655
17NEK11.97326261
18WNK31.93000303
19FRK1.88836392
20CDK191.88564041
21PLK41.86915388
22TRIM281.70951360
23SMG11.65448195
24TNIK1.57771869
25CSNK1G31.55474702
26CSNK1G11.53260704
27SRPK11.52464010
28TSSK61.50292602
29PLK11.48526298
30DYRK31.39668967
31BRSK21.34130804
32NME11.31756889
33BCKDK1.25153721
34CSNK1G21.24899408
35BMPR1B1.21006785
36MAP3K101.20966591
37ATR1.16123362
38DYRK21.07616458
39CHEK21.01424761
40CSNK1A1L1.00951843
41SIK30.99736398
42NME20.96628426
43EIF2AK20.92765526
44WEE10.92715910
45AURKB0.89020358
46CDK70.84126024
47DAPK10.81021791
48EIF2AK10.80048486
49RPS6KA40.74533396
50BRSK10.73348644
51ERBB30.72374524
52AURKA0.71183154
53STK40.68941054
54PRKD30.68636056
55EIF2AK30.68299001
56FGFR20.67180861
57BCR0.65057896
58GRK10.63673708
59CDK90.60102087
60NEK20.59261568
61STK30.58878508
62TXK0.53907921
63TLK10.53839964
64CSNK2A20.48603344
65PRKCI0.48576701
66ATM0.48023387
67CHEK10.47215501
68MARK30.46542127
69CSNK2A10.46139020
70ADRBK20.45894051
71RPS6KA50.45682771
72ALK0.44822026
73PAK40.43557628
74LIMK10.41227370
75NLK0.41012276
76CSNK1A10.37889860
77ITK0.34171003
78NEK90.34160127
79MELK0.34075893
80TEC0.33063848
81TGFBR10.32908378
82INSRR0.31596632
83TNK20.30687008
84STK38L0.29423937
85FLT30.27936576
86ACVR1B0.27921954
87CDK60.27409712
88CDK30.27123464
89OXSR10.24207720
90RPS6KB20.23760046
91MAP3K80.23661465
92DAPK30.22588451
93MAP3K120.19032185
94MAPKAPK50.18633969
95PRKCQ0.18349218
96CLK10.17556515
97CDK20.17018717
98CAMKK20.16485660
99KDR0.15648435
100CSNK1E0.15376508

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.74522446
2DNA replication_Homo sapiens_hsa030303.52225648
3Proteasome_Homo sapiens_hsa030503.44905044
4Ribosome_Homo sapiens_hsa030103.39028903
5Homologous recombination_Homo sapiens_hsa034403.29440150
6Protein export_Homo sapiens_hsa030602.89663019
7Oxidative phosphorylation_Homo sapiens_hsa001902.77806313
8RNA polymerase_Homo sapiens_hsa030202.72017430
9Fanconi anemia pathway_Homo sapiens_hsa034602.39710009
10Base excision repair_Homo sapiens_hsa034102.39345099
11Parkinsons disease_Homo sapiens_hsa050122.34107029
12One carbon pool by folate_Homo sapiens_hsa006702.22687238
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20341101
14Spliceosome_Homo sapiens_hsa030402.08726159
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99737776
16Nucleotide excision repair_Homo sapiens_hsa034201.98069792
17RNA transport_Homo sapiens_hsa030131.97116411
18Non-homologous end-joining_Homo sapiens_hsa034501.96316135
19Vitamin B6 metabolism_Homo sapiens_hsa007501.86082390
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.83938696
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75383219
22Pyrimidine metabolism_Homo sapiens_hsa002401.70588799
23Huntingtons disease_Homo sapiens_hsa050161.69791460
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69788735
25RNA degradation_Homo sapiens_hsa030181.67490939
26Fatty acid elongation_Homo sapiens_hsa000621.66560041
27Basal transcription factors_Homo sapiens_hsa030221.60838018
28Propanoate metabolism_Homo sapiens_hsa006401.59422406
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55097463
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55022168
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53487915
32Selenocompound metabolism_Homo sapiens_hsa004501.51435768
33Folate biosynthesis_Homo sapiens_hsa007901.49305657
34Cell cycle_Homo sapiens_hsa041101.47494366
35Alzheimers disease_Homo sapiens_hsa050101.35415568
36Purine metabolism_Homo sapiens_hsa002301.35249615
37Sulfur relay system_Homo sapiens_hsa041221.26238118
38Biosynthesis of amino acids_Homo sapiens_hsa012301.21801198
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15873925
40Pyruvate metabolism_Homo sapiens_hsa006201.13630318
41Butanoate metabolism_Homo sapiens_hsa006501.06035065
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05635141
43Phototransduction_Homo sapiens_hsa047441.01924440
44Carbon metabolism_Homo sapiens_hsa012000.99252065
45p53 signaling pathway_Homo sapiens_hsa041150.98207164
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93742760
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91180284
48mRNA surveillance pathway_Homo sapiens_hsa030150.88490685
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88082442
50Peroxisome_Homo sapiens_hsa041460.85731894
51Glutathione metabolism_Homo sapiens_hsa004800.85023116
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84148396
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79798972
54Steroid biosynthesis_Homo sapiens_hsa001000.79780124
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78699381
56Primary immunodeficiency_Homo sapiens_hsa053400.76352156
57Metabolic pathways_Homo sapiens_hsa011000.74126118
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73416158
59Oocyte meiosis_Homo sapiens_hsa041140.70627353
60Systemic lupus erythematosus_Homo sapiens_hsa053220.68309360
61Fatty acid degradation_Homo sapiens_hsa000710.59738390
62Alcoholism_Homo sapiens_hsa050340.57877767
63Tryptophan metabolism_Homo sapiens_hsa003800.56157841
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55314704
65Cardiac muscle contraction_Homo sapiens_hsa042600.55095498
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.54326233
67Fatty acid metabolism_Homo sapiens_hsa012120.54218420
68Regulation of autophagy_Homo sapiens_hsa041400.52198948
69beta-Alanine metabolism_Homo sapiens_hsa004100.51347523
70Sulfur metabolism_Homo sapiens_hsa009200.45864722
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45109829
72Caffeine metabolism_Homo sapiens_hsa002320.43054779
73Arginine and proline metabolism_Homo sapiens_hsa003300.42483968
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41407513
75Vitamin digestion and absorption_Homo sapiens_hsa049770.40891553
76Tyrosine metabolism_Homo sapiens_hsa003500.39914858
77Retinol metabolism_Homo sapiens_hsa008300.35820943
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33565214
79Pentose phosphate pathway_Homo sapiens_hsa000300.32125601
80N-Glycan biosynthesis_Homo sapiens_hsa005100.32098353
81Basal cell carcinoma_Homo sapiens_hsa052170.29833077
82Fructose and mannose metabolism_Homo sapiens_hsa000510.26316928
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25305340
84Epstein-Barr virus infection_Homo sapiens_hsa051690.25019038
85Thyroid cancer_Homo sapiens_hsa052160.22562685
86Linoleic acid metabolism_Homo sapiens_hsa005910.20884671
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18383790
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18028146
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17747082
90Collecting duct acid secretion_Homo sapiens_hsa049660.16932907
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16296561
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.15840926
93Viral carcinogenesis_Homo sapiens_hsa052030.14178273
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13871342
95Lysine degradation_Homo sapiens_hsa003100.12552088
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.12378951
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09918839
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08143611
99Ether lipid metabolism_Homo sapiens_hsa005650.07882171
100Phenylalanine metabolism_Homo sapiens_hsa003600.07177040

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »